Daniel J Penny

Summary

Affiliation: Royal Children's Hospital
Country: Australia

Publications

  1. ncbi request reprint Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery
    Christian Stocker
    Department of Intensive Care, Royal Children s Hospital, Flemington Road, 3052, Parkville, Victoria, Australia
    Intensive Care Med 29:1996-2003. 2003
  2. ncbi request reprint The systemic delivery and consumption of oxygen in the infant after cardiac surgery
    Daniel J Penny
    The Department of Cardiology, The Royal Children s Hospital, The Murdoch Children s Research Institute, Australia
    Cardiol Young 16:144-50. 2006
  3. ncbi request reprint What's happening in paediatric cardiology?
    Daniel J Penny
    Department of Cardiology, The Royal Children s Hospital, Australia
    Heart Lung Circ 13:S24-30. 2004
  4. ncbi request reprint Transcatheter closure of an atrial septal defect after a road traffic crash
    Daniel J Penny
    Grown Up Congenital Heart Disease Unit, Middlesex Hospital, London, United Kingdom
    J Trauma 55:559-60. 2003
  5. ncbi request reprint Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension
    Lara S Shekerdemian
    Department of Cardiac Intensive Care, Great Ormond Street Hospital, London, United Kingdom
    Am J Respir Crit Care Med 165:1098-102. 2002
  6. doi request reprint Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: a randomized controlled trial
    Bryn O Jones
    Department of Cardiology, Royal Children s Hospital, Melbourne, Victoria, Australia Heart Research Group, Murdoch Children s Research Institute, Parkville, Victoria, Australia Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
    J Thorac Cardiovasc Surg 146:1334-40. 2013
  7. ncbi request reprint The endothelin antagonist BQ123 reduces pulmonary vascular resistance after surgical intervention for congenital heart disease
    Ingram Schulze-Neick
    Cardiac Intensive Care Unit, Department of Vascular Biology and Pharmacology, and Cardiothoracic Unit, Great Ormond Street Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 124:435-41. 2002
  8. doi request reprint Impact of levosimendan on brain injury patterns in a lamb model of infant cardiopulmonary bypass
    Poongundran Namachivayam
    1 Pediatric Intensive Care Unit, The Royal Children s Hospital, Melbourne, Australia 2 Murdoch Children s Research Institute, Melbourne, Australia
    Pediatr Res 76:64-71. 2014
  9. ncbi request reprint Interaction between inhaled nitric oxide and intravenous sildenafil in a porcine model of meconium aspiration syndrome
    Lara S Shekerdemian
    Paediatric Intensive Care Unit, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    Pediatr Res 55:413-8. 2004
  10. ncbi request reprint Endothelin-A receptor blockade and inhaled nitric oxide in a porcine model of meconium aspiration syndrome
    Lara S Shekerdemian
    Paediatric Intensive Care Unit, Royal Children s Hospital, Parkville, Melbourne, Victoria 3052, Australia
    Pediatr Res 56:353-8. 2004

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery
    Christian Stocker
    Department of Intensive Care, Royal Children s Hospital, Flemington Road, 3052, Parkville, Victoria, Australia
    Intensive Care Med 29:1996-2003. 2003
    ..To investigate the acute effects of intravenous sildenafil on haemodynamics and oxygenation, and its interaction with inhaled nitric oxide (iNO) in infants at risk of pulmonary hypertension early after cardiac surgery...
  2. ncbi request reprint The systemic delivery and consumption of oxygen in the infant after cardiac surgery
    Daniel J Penny
    The Department of Cardiology, The Royal Children s Hospital, The Murdoch Children s Research Institute, Australia
    Cardiol Young 16:144-50. 2006
  3. ncbi request reprint What's happening in paediatric cardiology?
    Daniel J Penny
    Department of Cardiology, The Royal Children s Hospital, Australia
    Heart Lung Circ 13:S24-30. 2004
    ....
  4. ncbi request reprint Transcatheter closure of an atrial septal defect after a road traffic crash
    Daniel J Penny
    Grown Up Congenital Heart Disease Unit, Middlesex Hospital, London, United Kingdom
    J Trauma 55:559-60. 2003
  5. ncbi request reprint Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension
    Lara S Shekerdemian
    Department of Cardiac Intensive Care, Great Ormond Street Hospital, London, United Kingdom
    Am J Respir Crit Care Med 165:1098-102. 2002
    ..Intravenous sildenafil is a selective and highly effective pulmonary vasodilator, which is at least as effective as inhaled nitric oxide, in this model of neonatal persistent pulmonary hypertension...
  6. doi request reprint Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: a randomized controlled trial
    Bryn O Jones
    Department of Cardiology, Royal Children s Hospital, Melbourne, Victoria, Australia Heart Research Group, Murdoch Children s Research Institute, Parkville, Victoria, Australia Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
    J Thorac Cardiovasc Surg 146:1334-40. 2013
    ..No studies have examined this technique in neonates. The present study was performed to examine the remote ischemic preconditioning efficacy in this high-risk patient group...
  7. ncbi request reprint The endothelin antagonist BQ123 reduces pulmonary vascular resistance after surgical intervention for congenital heart disease
    Ingram Schulze-Neick
    Cardiac Intensive Care Unit, Department of Vascular Biology and Pharmacology, and Cardiothoracic Unit, Great Ormond Street Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 124:435-41. 2002
    ....
  8. doi request reprint Impact of levosimendan on brain injury patterns in a lamb model of infant cardiopulmonary bypass
    Poongundran Namachivayam
    1 Pediatric Intensive Care Unit, The Royal Children s Hospital, Melbourne, Australia 2 Murdoch Children s Research Institute, Melbourne, Australia
    Pediatr Res 76:64-71. 2014
    ..The effects of levosimendan (Levo) on injury patterns in the immature brain following cardiopulmonary bypass (CPB) are unknown...
  9. ncbi request reprint Interaction between inhaled nitric oxide and intravenous sildenafil in a porcine model of meconium aspiration syndrome
    Lara S Shekerdemian
    Paediatric Intensive Care Unit, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    Pediatr Res 55:413-8. 2004
    ..5 mg/kg produced profound pulmonary vasodilation, but this was coupled with an unacceptable deterioration in oxygenation and systemic vasodilation in this model of pulmonary hypertension with acute parenchymal lung disease...
  10. ncbi request reprint Endothelin-A receptor blockade and inhaled nitric oxide in a porcine model of meconium aspiration syndrome
    Lara S Shekerdemian
    Paediatric Intensive Care Unit, Royal Children s Hospital, Parkville, Melbourne, Victoria 3052, Australia
    Pediatr Res 56:353-8. 2004
    ..Endothelin-1 levels increased with both agents. BQ-123 was found to be a highly effective pulmonary vasodilator and augmented the effects of nitric oxide in this model of acute pulmonary hypertension...
  11. ncbi request reprint Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children
    Poongundran Namachivayam
    Department of Intensive Care, The Royal Children s Hospital, Melbourne, Australia
    Am J Respir Crit Care Med 174:1042-7. 2006
    ..There is anecdotal evidence that sildenafil, a phosphodiesterase-5 inhibitor, may prevent recurrence of rebound...
  12. doi request reprint Cardiac magnetic resonance imaging prior to bidirectional cavopulmonary connection in hypoplastic left heart syndrome
    Bryn O Jones
    Department of Cardiology, The Royal Children s Hospital, Parkville, Melbourne, Australia
    Heart Lung Circ 19:535-40. 2010
    ..Therefore our unit changed to cardiac Magnetic Resonance Imaging (MRI) in 2006. We aimed to compare peri-operative outcomes before and after this change...
  13. ncbi request reprint Aortic wave intensity analysis of ventricular-vascular interaction during incremental dobutamine infusion in adult sheep
    Daniel J Penny
    Department of Cardiology, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    Am J Physiol Heart Circ Physiol 294:H481-9. 2008
    ..001) that produced earlier and enhanced aortic blood deceleration. These findings provide new insights into the ventricular-vascular interaction of dobutamine...
  14. ncbi request reprint Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass
    Christian F Stocker
    Departments of Intensive Care, The Royal Children s Hospital, Melbourne, Australia
    Crit Care Med 35:252-9. 2007
    ..The objectives of our study were to define the early precipitants of the reduced cardiac output and to investigate the effects on these of milrinone and levosimendan in a model of pediatric cardiopulmonary bypass...
  15. doi request reprint Amplitude-integrated electroencephalography and brain injury in infants undergoing Norwood-type operations
    Julia K Gunn
    Department of Neonatal Medicine, The Royal Children s Hospital, Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
    Ann Thorac Surg 93:170-6. 2012
    ....
  16. doi request reprint Impact of antenatal diagnosis of hypoplastic left heart syndrome on the clinical presentation and surgical outcomes: the Australian experience
    Venkatesan Sivarajan
    Department of Intensive Care, The Royal Children s Hospital, Melbourne, Australia
    J Paediatr Child Health 45:112-7. 2009
    ..The study aims to review the impact of antenatal diagnosis on the early clinical course of infants with HLHS in Australia...
  17. ncbi request reprint Measured versus estimated oxygen consumption in ventilated patients with congenital heart disease: the validity of predictive equations
    Jia Li
    Department of Cardiology, Great Ormond Street Hospital, London, UK
    Crit Care Med 31:1235-40. 2003
    ..To determine the validity of predictive equations in calculating oxygen consumption (Vo(2)) in ventilated patients with congenital heart disease...
  18. doi request reprint Management of the sick neonate with suspected heart disease
    Paul A Brooks
    Department of Cardiology, The Royal Children s Hospital, Melbourne, Australia
    Early Hum Dev 84:155-9. 2008
    ....
  19. doi request reprint Increased myocardial methionine-enkephalin with reduced arterial oxygenation in congenital heart disease
    Olivier W V van den Brink
    Department of Cardiothoracic Surgery, Alfred Hospital, Department of Surgery, Monash University, Murdoch Children s Research Institute, Critical Care and Neurosciences, Heart Research, Victorian Paediatric Cardiac Surgery Unit, Department of Cardiology, Royal Children s Hospital and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
    J Paediatr Child Health 50:E63-7. 2014
    ..Cardiac opioid peptides have been identified to exert important adaptive metabolic signalling for cardioprotection against ischaemia or hypoxia-related injury...
  20. ncbi request reprint Respiratory syncytial virus immunoprophylaxis in high-risk infants with heart disease
    Peta M A Alexander
    Department of Cardiology, The Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 48:395-401. 2012
    ..Passive immunisation with palivizumab is recommended in many countries for children with haemodynamically significant cardiac disease. We trialled respiratory syncytial virus (RSV) immunoprophylaxis in such infants during 2008–2009...
  21. ncbi request reprint Preliminary experience with bosentan as initial therapy in childhood idiopathic pulmonary arterial hypertension
    Catherine M Simpson
    Department of Cardiology, The Royal Children s Hospital, Melbourne, Victoria, Australia
    J Heart Lung Transplant 25:469-73. 2006
    ..04). Our findings indicate treatment with bosentan permits a delay in IPAH disease progression and, in combination with other therapies, improves survival compared with historic control patients...
  22. ncbi request reprint Effect of intravenous sildenafil on pulmonary hemodynamics and gas exchange in the presence and absence of acute lung injury in piglets
    Pia K Ryhammer
    Department of Anesthesia and Intensive Care and Institute of Experimental Clinical Research, Aarhus University Hospital, 8200 Aarhus N, Denmark
    Pediatr Res 59:762-6. 2006
    ..In conclusion, sildenafil is a potent pulmonary vasodilator. However, it should be administered with caution in the presence of lung injury because of a dose-related increase in oxygenation index and concomitant systemic vasodilatation...
  23. ncbi request reprint Insulin-like growth factor 1 improves the relationship between systemic oxygen consumption and delivery in piglets after cardiopulmonary bypass
    Jia Li
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 127:1436-41. 2004
    ..We sought to assess the effects of insulin-like growth factor 1 on the balance between systemic oxygen consumption and oxygen delivery after cardiopulmonary bypass in piglets...
  24. ncbi request reprint Extracorporeal cardiopulmonary resuscitation: another piece of the jigsaw
    Stephen B Horton
    Crit Care Med 33:1659-60. 2005
  25. ncbi request reprint Right ventricular myocardial responses to chronic pulmonary regurgitation in lambs: disturbances of activation and conduction
    Rosaire Gray
    Institute of Urology and Nephrology, University College, London, UK
    Pediatr Res 54:529-35. 2003
    ..These may contribute to the development of arrhythmias associated with PR, including those in patients after tetralogy repair...
  26. ncbi request reprint Risk factors for long intensive care unit stay after cardiopulmonary bypass in children
    Kate L Brown
    Cardiac Intensive Care Unit, Great Ormond Street Hospital for Sick Children, London, UK
    Crit Care Med 31:28-33. 2003
    ..To identify factors associated with longer ICU stays that are potential targets for quality improvement...
  27. ncbi request reprint Transcatheter closure of a patent arterial duct in a patient on veno-arterial extracorporeal membrane oxygenation
    Kate L Brown
    Cardiac Intensive Care Unit, Great Ormond Street Hospital, London, UK
    Intensive Care Med 28:501-3. 2002
    ..This is the first report of transcatheter occlusion of a patent arterial duct in an infant on ECMO support...
  28. ncbi request reprint Divergent effects of NO synthase inhibition on systemic and myocardial O2 delivery and consumption during dobutamine infusion in sheep
    Daniel J Penny
    Department of Cardiology, Royal Children s Hospital, Parkville, 3052, Victoria, Australia
    Pflugers Arch 443:601-8. 2002
    ..These results suggest that NO modulated the baseline balance between systemic, but not myocardial, DO2 and. However, NO did not additionally alter dobutamine-related changes in either systemic or myocardial DO2 and balance...