Derek J Richard

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc ATM mediated phosphorylation of CHD4 contributes to genome maintenance
    Aaron J Urquhart
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Genome Integr 2:1. 2011
  2. pmc hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
    Derek J Richard
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Nucleic Acids Res 39:3643-51. 2011
  3. pmc Nucleophosmin: from structure and function to disease development
    Joseph K Box
    School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia
    BMC Mol Biol 17:19. 2016
  4. pmc Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
    Joshua T Burgess
    Cancer and Ageing Program, Institute of Health and Biomedical Innovation at the Translational Research Institute TRI, Queensland University of Technology QUT and Princess Alexandra Hospital, Level 6, Translational Research Institute, Brisbane, QLD, Australia
    Cell Death Dis 7:e2469. 2016
  5. pmc Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin
    Emma Bolderson
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    J Biol Chem 287:28122-31. 2012
  6. pmc hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex
    Derek J Richard
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Nucleic Acids Res 39:1692-702. 2011
  7. pmc SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer
    Joshua T Burgess
    Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute TRI, Queensland University of Technology, Brisbane, Australia
    Oncotarget 7:72807-72818. 2016
  8. doi request reprint Drug Discovery Approaches Utilizing Three-Dimensional Cell Culture
    Sarah Louise Ryan
    1 Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Assay Drug Dev Technol 14:19-28. 2016
  9. pmc Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation
    Nicolas Paquet
    School of Biomedical Science, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia
    BMC Mol Biol 15:27. 2014
  10. pmc BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability
    Kienan I Savage
    Authors Affiliations Centre for Cancer Research and Cell Biology Institute for Global Food Security, Queen s University Belfast, Belfast, United Kingdom Department of Physics, Radiation Biophysics Laboratory, University of Naples Federico II, Naples, Italy The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Australia
    Cancer Res 74:2773-84. 2014

Collaborators

Detail Information

Publications12

  1. pmc ATM mediated phosphorylation of CHD4 contributes to genome maintenance
    Aaron J Urquhart
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Genome Integr 2:1. 2011
    ..This response requires a number of processes including stabilisation of the DSB, signalling of the break and repair. It is becoming increasingly apparent that one key step in this process is chromatin remodelling...
  2. pmc hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
    Derek J Richard
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Nucleic Acids Res 39:3643-51. 2011
    ..Interestingly, analysis of two point mutations in NBS1, associated with Nijmegen breakage syndrome, revealed weaker binding to hSSB1, suggesting a possible disease mechanism...
  3. pmc Nucleophosmin: from structure and function to disease development
    Joseph K Box
    School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia
    BMC Mol Biol 17:19. 2016
    ..The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers. ..
  4. pmc Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
    Joshua T Burgess
    Cancer and Ageing Program, Institute of Health and Biomedical Innovation at the Translational Research Institute TRI, Queensland University of Technology QUT and Princess Alexandra Hospital, Level 6, Translational Research Institute, Brisbane, QLD, Australia
    Cell Death Dis 7:e2469. 2016
    ..The use of the NF-κB inhibitor DHMEQ demonstrated that the effect of SASH1 on apoptosis was dependent on NF-κB, indicating a codependence between SASH1 and NF-κB for this process...
  5. pmc Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin
    Emma Bolderson
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    J Biol Chem 287:28122-31. 2012
    ..These results suggest a novel mechanism of KAP-1-mediated chromatin restructuring via Chk2-regulated HP1-β exchange from heterochromatin, promoting DNA repair...
  6. pmc hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex
    Derek J Richard
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Nucleic Acids Res 39:1692-702. 2011
    ..These findings, together with previous work establish essential roles of hSSB1 in controlling ATM activation and activity, and subsequent DSB resection and homologous recombination (HR)...
  7. pmc SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer
    Joshua T Burgess
    Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute TRI, Queensland University of Technology, Brisbane, Australia
    Oncotarget 7:72807-72818. 2016
    ..Pharmacologic induction of SASH1 by chloropyramine treatment of breast cancer warrants further preclinical and clinical investigation...
  8. doi request reprint Drug Discovery Approaches Utilizing Three-Dimensional Cell Culture
    Sarah Louise Ryan
    1 Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Assay Drug Dev Technol 14:19-28. 2016
    ..We assess their amenability with high-content screening and HTS and highlight our own work in attempting to address many of the practical problems that are hampering the successful deployment of 3D cell systems in mainstream research. ..
  9. pmc Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation
    Nicolas Paquet
    School of Biomedical Science, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia
    BMC Mol Biol 15:27. 2014
    ..This mutation was described to cause instability in the BANF1 protein, causing a disruption of the nuclear envelope structure...
  10. pmc BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability
    Kienan I Savage
    Authors Affiliations Centre for Cancer Research and Cell Biology Institute for Global Food Security, Queen s University Belfast, Belfast, United Kingdom Department of Physics, Radiation Biophysics Laboratory, University of Naples Federico II, Naples, Italy The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Australia
    Cancer Res 74:2773-84. 2014
    ..Our findings provide pivotal new insights into why BRCA1 mutation drives the formation of tumors in estrogen-regulated tissues, despite the general role of BRCA1 in DNA repair in all cell types...
  11. pmc Promotion of a cancer-like phenotype, through chronic exposure to inflammatory cytokines and hypoxia in a bronchial epithelial cell line model
    Anne Marie Baird
    Cancer and Ageing Research Program, Queensland University of Technology, Brisbane, Australia
    Sci Rep 6:18907. 2016
    ..In turn these mediators may be of benefit for biomarker and/or immune-therapy target studies. This project provides an important inflammatory in vitro model for further immuno-oncology studies in the lung cancer setting. ..
  12. pmc Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
    Emma Bolderson
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Nucleic Acids Res 38:1821-31. 2010
    ..These data establish a role for Exo1 in resection of DSBs in human cells, highlighting the critical requirement of Exo1 for DSB repair via HR and thus the maintenance of genomic stability...