Patrick O Humbert

Summary

Affiliation: Peter MacCallum Cancer Centre
Country: Australia

Publications

  1. ncbi request reprint hScrib is a functional homologue of the Drosophila tumour suppressor Scribble
    Lukas E Dow
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Oncogene 22:9225-30. 2003
  2. doi request reprint Mitotic spindle orientation: semaphorin-plexin signaling flags the way
    Patrick O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia Department of Molecular Biology and Biochemistry, The University of Melbourne, Parkville, Victoria 3052, Australia Electronic address
    Dev Cell 33:243-4. 2015
  3. pmc Discovery and analysis of consistent active sub-networks in cancers
    Raj K Gaire
    NICTA, Victoria Laboratory and Department of Computing and Information Systems, University of Melbourne, Parkville, VIC 3010, Australia
    BMC Bioinformatics 14:S7. 2013
  4. ncbi request reprint The Scribble and Par complexes in polarity and migration: friends or foes?
    Patrick O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia
    Trends Cell Biol 16:622-30. 2006
  5. doi request reprint Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module
    P O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Oncogene 27:6888-907. 2008
  6. pmc Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis
    Anthony M Brumby
    Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Genetics 188:105-25. 2011
  7. pmc An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery
    Lee F Willoughby
    Cell cycle and development laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne 3002, Victoria, Australia
    Dis Model Mech 6:521-9. 2013
  8. pmc Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms
    Jane Oliaro
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia
    J Immunol 185:367-75. 2010
  9. pmc SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
    Helen B Pearson
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Clin Invest 121:4257-67. 2011
  10. ncbi request reprint Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis
    Lukas E Dow
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Center, Melbourne, Australia
    Int Rev Cytol 262:253-302. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint hScrib is a functional homologue of the Drosophila tumour suppressor Scribble
    Lukas E Dow
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Oncogene 22:9225-30. 2003
    ..These data demonstrate that hScrib is a functional homologue of DmScrib and therefore predict an important role for hScrib in the suppression of mammalian tumorigenesis...
  2. doi request reprint Mitotic spindle orientation: semaphorin-plexin signaling flags the way
    Patrick O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia Department of Molecular Biology and Biochemistry, The University of Melbourne, Parkville, Victoria 3052, Australia Electronic address
    Dev Cell 33:243-4. 2015
    ..In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney development and repair...
  3. pmc Discovery and analysis of consistent active sub-networks in cancers
    Raj K Gaire
    NICTA, Victoria Laboratory and Department of Computing and Information Systems, University of Melbourne, Parkville, VIC 3010, Australia
    BMC Bioinformatics 14:S7. 2013
    ..This result suggests that subtypes of different cancers can show molecular similarities indicating that the therapeutic approaches in different types of cancers may be shared...
  4. ncbi request reprint The Scribble and Par complexes in polarity and migration: friends or foes?
    Patrick O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia
    Trends Cell Biol 16:622-30. 2006
    ..Based on the known interactions of Scribble and Par complexes with each other and with other signalling pathways, we propose models by which Par and Scribble might interact to regulate cell migration...
  5. doi request reprint Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module
    P O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Oncogene 27:6888-907. 2008
    ..We review the evidence for the involvement of Scribble, Dlg, and Lgl in cancer, and how the various functions ascribed to these tumour suppressors in Drosophila and mammalian systems may impact on the process of tumourigenesis...
  6. pmc Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis
    Anthony M Brumby
    Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Genetics 188:105-25. 2011
    ..Collectively our analysis reveals the importance of the RhoGEF/Rho-family/JNK pathway in cooperative tumorigenesis with Ras(ACT)...
  7. pmc An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery
    Lee F Willoughby
    Cell cycle and development laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne 3002, Victoria, Australia
    Dis Model Mech 6:521-9. 2013
    ..The platform can also be adapted for use with other disease models, thus offering widespread applications in drug development...
  8. pmc Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms
    Jane Oliaro
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia
    J Immunol 185:367-75. 2010
    ..These findings suggest that T cells have selectively adapted a number of evolutionarily conserved mechanisms to generate diversity through asymmetric cell division...
  9. pmc SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
    Helen B Pearson
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Clin Invest 121:4257-67. 2011
    ..These data suggest that the polarity network could provide a new avenue for therapeutic intervention...
  10. ncbi request reprint Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis
    Lukas E Dow
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Center, Melbourne, Australia
    Int Rev Cytol 262:253-302. 2007
    ..Particular reference will be made as to how the Scribble and Par polarity complexes may be involved in the regulation of apical-basal polarity, migration, and tumorigenesis...
  11. doi request reprint Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo
    Kelly M Ramsbottom
    Cancer Immunology Laboratory, The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Immunol Cell Biol 94:306-11. 2016
    ..These results reveal a novel role for Lgl-1 in the regulation of virus-specific T-cell responses and antitumor immunity. ..
  12. doi request reprint Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers
    Benjamin Namdarian
    Department of Surgery, Division of Urology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    Urol Oncol 31:649-55. 2013
    ..Our aim was to investigate the role of tight junction proteins, Par3/Par6/atypical protein kinase C (APKC), Discs large (Dlg), and Scribble in human bladder pathogenesis...
  13. doi request reprint Localization, not important in all tumor-suppressing properties: a lesson learnt from scribble
    Imogen A Elsum
    Cell Cycle and Cancer Genetics, Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia
    Cells Tissues Organs 198:1-11. 2013
    ....
  14. doi request reprint The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man
    Imogen Elsum
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Essays Biochem 53:141-68. 2012
    ..In addition to these physiological roles, an important role for polarity proteins in cancer progression has also been uncovered, with loss of polarity and tissue architecture being strongly correlated with metastatic disease...
  15. doi request reprint Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation
    Imogen A Elsum
    Cell Cycle and Cancer Genetics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia
    J Cell Sci 126:3990-9. 2013
    ..These data suggests a novel role for Scribble in positively regulating tight junction assembly through transcriptional regulation of an EMT signaling program. ..
  16. pmc Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia
    Edwin D Hawkins
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 9:e87376. 2014
    ..These results suggest that the role of Lgl1 in the haematopoietic lineage might be restricted to specific co-operating mutations and a limited number of cellular contexts...
  17. doi request reprint Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity
    Edwin D Hawkins
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia
    Nat Commun 4:1801. 2013
    ..Taken together, our results indicate that B cell differentiation does not require polarity proteins of the Scribble complex, and the findings do not support a role for asymmetric cell division in B cell activation and differentiation...
  18. pmc Asymmetric cell division during T cell development controls downstream fate
    Kim Pham
    Immune Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Centre for Micro Photonics, Faculty of Science, Engineering, and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia
    J Cell Biol 210:933-50. 2015
    ..These findings indicate that ACD enables the thymic microenvironment to orchestrate fate decisions related to differentiation and self-renewal. ..
  19. doi request reprint Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions
    Nathan J Godde
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Center, East Melbourne, VIC 3002, Australia
    J Mammary Gland Biol Neoplasia 15:149-68. 2010
    ....
  20. pmc Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland
    Nathan J Godde
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia
    PLoS Genet 10:e1004323. 2014
    ....
  21. doi request reprint Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines
    Xiaomeng Zhang
    Cell Growth and Proliferation Laboratory and Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 69:6033-41. 2009
    ..melanogaster and optimally activate Sd. This shows that Yki/YAP WW domains have distinct regulatory roles in different cell types and implies the existence of proteins that promote tissue growth in collaboration with Yki and Sd...
  22. pmc Keratin 76 is required for tight junction function and maintenance of the skin barrier
    Tia DiTommaso
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    PLoS Genet 10:e1004706. 2014
    ....
  23. pmc The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation
    Christina B Wölwer
    Cell Cycle and Cancer Genetics, Peter MacCallum Cancer Centre, East Melbourne, Australia
    PLoS ONE 12:e0170295. 2017
    ..Together our results put into question a role for cell polarity and asymmetric cell division in erythroid enucleation...
  24. pmc Calcium Signaling Is Required for Erythroid Enucleation
    Christina B Wölwer
    Cell Cycle and Cancer Genetics, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    PLoS ONE 11:e0146201. 2016
    ..Together these functional studies highlight a critical role for calcium signaling in the regulation of erythroid enucleation. ..
  25. pmc A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation
    Christina B Wölwer
    Cell Cycle and Cancer Genetics, Peter MacCallum Cancer Centre, Melbourne, Australia
    PLoS ONE 10:e0142655. 2015
    ..Importantly, we demonstrate that when coupled with imaging analysis, this approach provides a powerful means to identify and characterize rate limiting steps involved in the erythroid enucleation process. ..
  26. pmc Epidermal wound repair is regulated by the planar cell polarity signaling pathway
    Jacinta Caddy
    Rotary Bone Marrow Research Laboratories, Parkville, Victoria 3050, Australia
    Dev Cell 19:138-47. 2010
    ..These results define a role for Grhl3 in PCP signaling and broadly implicate this pathway in epidermal repair...
  27. doi request reprint Dissecting the role of polarity regulators in cancer through the use of mouse models
    Nathan J Godde
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, VIC 8006, Australia
    Exp Cell Res 328:249-57. 2014
    ..They also highlight how aberrant polarity signaling could provide a novel route for therapeutic intervention to improve our management of malignancies in the clinic. ..
  28. ncbi request reprint A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation
    Mandy J Ludford-Menting
    Immune Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Immunity 22:737-48. 2005
    ..By dynamically coordinating molecular distribution throughout the T cell, this network provides a mechanism by which T cell function and polarity are linked...
  29. ncbi request reprint New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models
    Patrick O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia
    Curr Opin Cell Biol 16:614-22. 2004
    ..Moreover, checkpoint regulators, which are not essential for viability in yeast and cultured cells, play important roles in cell cycle control during development...
  30. ncbi request reprint A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization
    Lorey K Smith
    1 Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Victoria, Australia
    Assay Drug Dev Technol 14:478-488. 2016
    ..This method is broadly applicable to genome-wide and large-scale compound screening of membrane-bound proteins, and when coupled with pathway analysis the dataset becomes even more valuable and can provide predictive mechanistic insight...
  31. doi request reprint Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling
    Christoph Kruse
    From the Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany C K, K P, R P B, C F, U R M Walter Brendel Center of Experimental Medicine, Ludwig Maximilians University, Munich, Germany A R M K, M S Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, and Sir Peter MacCallum Department of Oncology, Department of Pathology, Department of Molecular Biology and Biochemistry, The University of Melbourne, Parkville, Victoria, Australia P O H and DZHK German Centre for Cardiovascular Research, partner sites Rhine Main and Munich, Germany C K, A R M K, K P, M S, R P B, C F, U R M
    Arterioscler Thromb Vasc Biol 35:1954-62. 2015
    ..Because integrin α5 signals the presence of the inflammatory matrix protein fibronectin, we hypothesized that Scrib contributes to endothelial inflammatory signaling...
  32. doi request reprint Increasing intracellular bioavailable copper selectively targets prostate cancer cells
    Michael A Cater
    Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    ACS Chem Biol 8:1621-31. 2013
    ....