David Goldstein

Summary

Affiliation: New South Wales
Country: Australia

Publications

  1. doi request reprint nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial
    David Goldstein
    Prince of Wales Hospital, University of New South Wales, Sydney, NSW, Australia DG Royal Victoria Regional Health Centre, Barrie, ON, Canada RHEM Hôpital Beaujon, Clichy, France PH Klinikum Grosshadern, University of Munich, Munich, Germany VH Universitätsklinikum Würzburg, Wurzburg, Germany VK Hospital Clinico San Carlos, Madrid, Spain JS Medizinische Universität Wien, Wien, Austria WS Ospedale Niguarda Ca Granda, Milan, Italy SS Vall d Hebron University Hospital and Institute of Oncology VHIO, Universitat Autonoma de Barcelona, Barcelona, Spain JT Hôpital Saint Antoine, Paris, France LT Azienda Ospedaliera Universitaria Integrata and University of Verona, Verona, Italy GT Hôpital Erasme, Brussels, Belgium JLVL Royal Hobart Hospital, Hobart, Australia RY Celgene Corporation, Summit, NJ DNP Celgene Corporation, Summit, NJ BL Celgene Corporation, Boudry, Switzerland AR Virginia G Piper Cancer Center at Scottsdale Healthcare TGen, Scottsdale, AZ DDVH
    J Natl Cancer Inst 107:. 2015
  2. doi request reprint Development of peripheral neuropathy and its association with survival during treatment with nab-paclitaxel plus gemcitabine for patients with metastatic adenocarcinoma of the pancreas: A subset analysis from a randomised phase III trial (MPACT)
    David Goldstein
    Prince of Wales Hospital, Department of Oncology, South Eastern Sydney Illawarra, NSW Health, Barker Street, Randwick, NSW 2031, Australia University of New South Wales, Australia Electronic address
    Eur J Cancer 52:85-91. 2016
  3. pmc Gemcitabine with a specific conformal 3D 5FU radiochemotherapy technique is safe and effective in the definitive management of locally advanced pancreatic cancer
    D Goldstein
    Department of Medical Oncology, Prince of Wales Hospital, Barker Street, Randwick, New South Wales 2031, Australia
    Br J Cancer 97:464-71. 2007
  4. pmc The GOFURTGO Study: AGITG phase II study of fixed dose rate gemcitabine-oxaliplatin integrated with concomitant 5FU and 3-D conformal radiotherapy for the treatment of localised pancreatic cancer
    D Goldstein
    Department of Medical Oncology, Prince of Wales Hospital, High Street, Randwick, New South Wales 2031, Australia
    Br J Cancer 106:61-9. 2012
  5. doi request reprint Oxaliplatin-induced neurotoxicity: changes in axonal excitability precede development of neuropathy
    Susanna B Park
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Brain 132:2712-23. 2009
  6. doi request reprint Should culture affect practice? A comparison of prognostic discussions in consultations with immigrant versus native-born cancer patients
    Phyllis N Butow
    Psycho oncology Co operative Research Group PoCoG, Transient Building, University of Sydney, NSW, Australia
    Patient Educ Couns 92:246-52. 2013
  7. doi request reprint A bridge between cultures: interpreters' perspectives of consultations with migrant oncology patients
    Phyllis N Butow
    School of Psychology, University of Sydney, Sydney, Australia
    Support Care Cancer 20:235-44. 2012
  8. doi request reprint Inferior health-related quality of life and psychological well-being in immigrant cancer survivors: a population-based study
    Phyllis N Butow
    Psycho oncology Co operative Research Group PoCoG, and School of Psychology, University of Sydney, Sydney, NSW, Australia
    Eur J Cancer 49:1948-56. 2013
  9. pmc Long-term neuropathy after oxaliplatin treatment: challenging the dictum of reversibility
    Susanna B Park
    Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    Oncologist 16:708-16. 2011
  10. doi request reprint Utilizing natural activity to dissect the pathophysiology of acute oxaliplatin-induced neuropathy
    Susanna B Park
    Prince of Wales Clinical School, Barker Street, Randwick, Sydney, NSW 2063, Australia
    Exp Neurol 227:120-7. 2011

Detail Information

Publications64

  1. doi request reprint nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial
    David Goldstein
    Prince of Wales Hospital, University of New South Wales, Sydney, NSW, Australia DG Royal Victoria Regional Health Centre, Barrie, ON, Canada RHEM Hôpital Beaujon, Clichy, France PH Klinikum Grosshadern, University of Munich, Munich, Germany VH Universitätsklinikum Würzburg, Wurzburg, Germany VK Hospital Clinico San Carlos, Madrid, Spain JS Medizinische Universität Wien, Wien, Austria WS Ospedale Niguarda Ca Granda, Milan, Italy SS Vall d Hebron University Hospital and Institute of Oncology VHIO, Universitat Autonoma de Barcelona, Barcelona, Spain JT Hôpital Saint Antoine, Paris, France LT Azienda Ospedaliera Universitaria Integrata and University of Verona, Verona, Italy GT Hôpital Erasme, Brussels, Belgium JLVL Royal Hobart Hospital, Hobart, Australia RY Celgene Corporation, Summit, NJ DNP Celgene Corporation, Summit, NJ BL Celgene Corporation, Boudry, Switzerland AR Virginia G Piper Cancer Center at Scottsdale Healthcare TGen, Scottsdale, AZ DDVH
    J Natl Cancer Inst 107:. 2015
    ..This report is an update of overall survival (OS) based on longer follow-up...
  2. doi request reprint Development of peripheral neuropathy and its association with survival during treatment with nab-paclitaxel plus gemcitabine for patients with metastatic adenocarcinoma of the pancreas: A subset analysis from a randomised phase III trial (MPACT)
    David Goldstein
    Prince of Wales Hospital, Department of Oncology, South Eastern Sydney Illawarra, NSW Health, Barker Street, Randwick, NSW 2031, Australia University of New South Wales, Australia Electronic address
    Eur J Cancer 52:85-91. 2016
    ..This exploratory analysis aimed to characterise the frequency, duration, and severity of PN with nab-P/Gem in the MPACT study...
  3. pmc Gemcitabine with a specific conformal 3D 5FU radiochemotherapy technique is safe and effective in the definitive management of locally advanced pancreatic cancer
    D Goldstein
    Department of Medical Oncology, Prince of Wales Hospital, Barker Street, Randwick, New South Wales 2031, Australia
    Br J Cancer 97:464-71. 2007
    ..This approach to treatment of locally advanced pancreatic cancer is safe and promising, with good local control for a substantial proportion of patients, and merits testing in a randomised trial...
  4. pmc The GOFURTGO Study: AGITG phase II study of fixed dose rate gemcitabine-oxaliplatin integrated with concomitant 5FU and 3-D conformal radiotherapy for the treatment of localised pancreatic cancer
    D Goldstein
    Department of Medical Oncology, Prince of Wales Hospital, High Street, Randwick, New South Wales 2031, Australia
    Br J Cancer 106:61-9. 2012
    ....
  5. doi request reprint Oxaliplatin-induced neurotoxicity: changes in axonal excitability precede development of neuropathy
    Susanna B Park
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Brain 132:2712-23. 2009
    ..05) than those left with mild or moderate neurotoxicity, suggesting that assessment of sensory excitability parameters may provide a sensitive biomarker of severity for oxaliplatin-induced neurotoxicity...
  6. doi request reprint Should culture affect practice? A comparison of prognostic discussions in consultations with immigrant versus native-born cancer patients
    Phyllis N Butow
    Psycho oncology Co operative Research Group PoCoG, Transient Building, University of Sydney, NSW, Australia
    Patient Educ Couns 92:246-52. 2013
    ..Poor prognosis is difficult to impart, particularly across a cultural divide. This study compared prognostic communication with immigrants (with and without interpreters) versus native-born patients in audio-taped oncology consultations...
  7. doi request reprint A bridge between cultures: interpreters' perspectives of consultations with migrant oncology patients
    Phyllis N Butow
    School of Psychology, University of Sydney, Sydney, Australia
    Support Care Cancer 20:235-44. 2012
    ..Little is known about interpreters' perceptions of their role and the challenges they face. This study aimed to obtain their perspective...
  8. doi request reprint Inferior health-related quality of life and psychological well-being in immigrant cancer survivors: a population-based study
    Phyllis N Butow
    Psycho oncology Co operative Research Group PoCoG, and School of Psychology, University of Sydney, Sydney, NSW, Australia
    Eur J Cancer 49:1948-56. 2013
    ..Potential targets for intervention include assistance in navigating the health system, translated information and cultural competency training for health professionals...
  9. pmc Long-term neuropathy after oxaliplatin treatment: challenging the dictum of reversibility
    Susanna B Park
    Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    Oncologist 16:708-16. 2011
    ..However, the long-term neurological sequelae have not been adequately described. The present study aimed to describe the natural history of oxaliplatin-induced neuropathy, using subjective and objective assessments...
  10. doi request reprint Utilizing natural activity to dissect the pathophysiology of acute oxaliplatin-induced neuropathy
    Susanna B Park
    Prince of Wales Clinical School, Barker Street, Randwick, Sydney, NSW 2063, Australia
    Exp Neurol 227:120-7. 2011
    ..Findings from the present series suggest that oxaliplatin affects nerve excitability through voltage-dependent mechanisms, with specific effects mediated through axonal Na(+) channel inactivation...
  11. doi request reprint Impact of oxaliplatin-induced neuropathy: a patient perspective
    Barbara K Bennett
    NSW Cancer Survivors Centre, University of New South Wales, Sydney, NSW, Australia
    Support Care Cancer 20:2959-67. 2012
    ..The improvement in survival for patients with early-stage colorectal cancer treated with oxaliplatin has highlighted the need for valid and reliable assessment of peripheral neuropathy...
  12. doi request reprint Cancer-related fatigue in women with breast cancer: outcomes of a 5-year prospective cohort study
    David Goldstein
    Prince of Wales Hospital, Randwick, Australia
    J Clin Oncol 30:1805-12. 2012
    ..Hence, relationships to cancer, surgery, and adjuvant therapy are unclear...
  13. doi request reprint Oxaliplatin-induced lhermitte's phenomenon as a manifestation of severe generalized neurotoxicity
    Susanna B Park
    Prince of Wales Medical Research Institute and Prince of Wales Clinical School, Sydney, NSW, Australia
    Oncology 77:342-8. 2009
    ..Limited cases have been described previously and the pathophysiology underlying Lhermitte's phenomenon in oxaliplatin-treated patients has not been established...
  14. doi request reprint Are visiting oncologists enough? A qualitative study of the needs of Australian rural and regional cancer patients, carers and health professionals
    Peter Grimison
    Sydney Cancer Centre, Camperdown, NSW, Australia
    Asia Pac J Clin Oncol 9:226-38. 2013
    ..We conducted a qualitative study of rural patients, carers and health professionals. It aimed to identify concerns about, and strategies to optimize cancer care from those with direct experience...
  15. doi request reprint Reducing disparity in outcomes for immigrants with cancer: a qualitative assessment of the feasibility and acceptability of a culturally targeted telephone-based supportive care intervention
    Joanne Shaw
    Surgical Outcomes Research Centre, Sydney Local Health District and School of Public Health, Royal Prince Alfred Hospital, University of Sydney, PO Box M157, Missenden Road, Sydney, New South Wales, 2050, Australia
    Support Care Cancer 21:2297-301. 2013
    ....
  16. doi request reprint Informatively missing quality of life and unmet needs sex data for immigrant and Anglo-Australian cancer patients and survivors
    Melanie L Bell
    Psycho oncology Co operative Research Group PoCoG, University of Sydney, Sydney, NSW, Australia
    Qual Life Res 22:2757-60. 2013
    ....
  17. doi request reprint Chemotherapy-induced peripheral neurotoxicity: a critical analysis
    Susanna B Park
    RG Menzies Fellow, Institute of Neurology, University College London, London, United Kingdom Neuroscience Research Australia and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    CA Cancer J Clin 63:419-37. 2013
    ..The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies...
  18. pmc Dose effects of oxaliplatin on persistent and transient Na+ conductances and the development of neurotoxicity
    Susanna B Park
    Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 6:e18469. 2011
    ..Given that a Na(+) channelopathy has been proposed as the mechanism underlying acute oxaliplatin-induced neuropathy, the present study aimed to determine specific mechanisms of Na(+) channel dysfunction...
  19. doi request reprint Single-agent irinotecan or FOLFIRI as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis [corrected]
    Stephen J Clarke
    Department of Medicine, Concord Hospital, Concord, Sydney, Australia
    Eur J Cancer 47:1826-36. 2011
    ..We compared toxicity (particularly diarrhoea), quality of life, and efficacy of combination chemotherapy and irinotecan in these patients...
  20. pmc Migrant health in cancer: outcome disparities and the determinant role of migrant-specific variables
    Ming Sze
    Psycho oncology Co operative Research Group, School of Psychology, University of Sydney, Sydney, New South Wales, Australia School of Psychology and Psychiatry, Monash University, Victoria, Australia Department of Cancer Experiences Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Department of Medical Oncology, Peter MacCallum Cancer Centre and Faculty of Medicine, Dentistry and Health Services, University of Melbourne, Melbourne, Victoria, Australia Centre for Oncology Education and Research Translation, Ingham Institute for Applied Medical Research, South Western Sydney Clinical School and Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia Department of Medical Oncology, Liverpool Hospital, Sydney, New South Wales, Australia Bankstown Lidcombe Hospital Cancer Centre, South Western Sydney Local Health District, Bankstown, New South Wales, Australia Department Medical Oncology, Eastern Health and Monash University, Box Hill, Victoria, Australia St George and Sutherland Cancer Care Centre, St George Hospital, Sydney, New South Wales, Australia Department of Medical Oncology, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Oncologist 20:523-31. 2015
    ..Further, it explored the relative contribution of ethnicity versus migrant-related variables...
  21. doi request reprint Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance
    Alain Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School and School of Medical Sciences Pathology, The University of New South Wales and Sydney, Sydney, NSW, Australia
    Cancer Res 68:7707-10. 2008
    ..Characterization of the mechanisms mediating PSC-cancer interactions will lead to the development of much needed alternative therapeutic approaches to improve disease outcome...
  22. doi request reprint Acute abnormalities of sensory nerve function associated with oxaliplatin-induced neurotoxicity
    Susanna B Park
    Prince of Wales Medical Research Institute, Barker St, Randwick, Sydney, New South Wales 2031
    J Clin Oncol 27:1243-9. 2009
    ..Because the mechanism of oxaliplatin-induced neurotoxicity remains unclear, the present study investigated the potential of axonal excitability techniques in identifying pathophysiologic mechanisms and early markers of nerve dysfunction...
  23. doi request reprint Reaching further with online education? The development of an effective online program in palliative oncology
    Bogda Koczwara
    Department of Medical Oncology, Flinders Medical Centre, Bedford Park, SA 5042, Australia
    J Cancer Educ 25:317-23. 2010
    ..Sixty-five (75%) respondents planned to review or change their practice as a result. The online program is effective in meeting learning needs of Australian health providers, reaching high numbers with high acceptability...
  24. doi request reprint Grappling with cultural differences; communication between oncologists and immigrant cancer patients with and without interpreters
    Phyllis Butow
    University of Sydney, NSW, Australia
    Patient Educ Couns 84:398-405. 2011
    ..Immigrants report challenges communicating with their health team. This study compared oncology consultations of immigrants with and without interpreters vs Anglo-Australian patients...
  25. pmc Dose modification and efficacy of nab-paclitaxel plus gemcitabine vs. gemcitabine for patients with metastatic pancreatic cancer: phase III MPACT trial
    Werner Scheithauer
    1 Medizinische Universität Wien, Wien, Austria 2 Division of Hematology Oncology, Mayo Clinic, Scottsdale, Arizona, USA 3 BC Cancer Agency, Vancouver, British Columbia, Canada 4 Vall d Hebron University Hospital and Institute of Oncology VHIO, Barcelona, Spain 5 Prince of Wales Hospital, Sydney, NSW, Australia 6 Hôpital Beaujon, Clichy, France 7 Universitätsklinikum Würzburg, Wurzburg, Germany 8 Celgene Corporation, Summit, New Jersey, USA 9 Celgene Corporation, Boudry, Switzerland 10 Translational Genomics Research Institute and Honor Health, Scottsdale, Arizona, USA
    J Gastrointest Oncol 7:469-78. 2016
    ....
  26. pmc Role of pancreatic stellate cells in pancreatic cancer metastasis
    Zhihong Xu
    Pancreatic Research Group, South Western Sydney Clinical School, School of Medical Sciences, Faculty of Medicine, Room 505, Level 5, Wallace Wurth Building, The University of New South Wales, Sydney, NSW 2052, Australia
    Am J Pathol 177:2585-96. 2010
    ..Human PSCs accompany cancer cells to metastatic sites, stimulate angiogenesis, and are able to intravasate/extravasate to and from blood vessels...
  27. doi request reprint Adjuvant chemotherapy for early colon cancer: what survival benefits make it worthwhile?
    Prunella Blinman
    NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia
    Eur J Cancer 46:1800-7. 2010
    ....
  28. doi request reprint Psychosocial well-being and supportive care needs of cancer patients living in urban and rural/regional areas: a systematic review
    Phyllis N Butow
    Psycho oncology Co operative Research Group PoCoG, University of Sydney, Sydney, NSW, Australia
    Support Care Cancer 20:1-22. 2012
    ..The aim of this study was to describe what is known about levels of morbidity and the experience and needs of people with cancer, and their informal caregivers, living in rural areas...
  29. pmc Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer
    Srinivasa P Pothula
    Pancreatic Research Group, South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    Br J Cancer 114:269-80. 2016
    ..Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer (PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway that may mediate this interaction is the HGF-c-MET pathway...
  30. ncbi request reprint Modification of leucovorin dose within a simplified FOLFOX regimen improves tolerability without compromising efficacy
    Stephen Clarke
    Department of Medical Oncology, Royal Prince Alfred Hospital Sydney Cancer Centre, Sydney, Australia
    Clin Colorectal Cancer 6:578-82. 2007
    ..This analysis assesses the efficacy and safety of a modified FOLFOX (oxaliplatin/leucovorin [LV]/5-fluorouracil [5-FU]) regimen given with a low dose of LV...
  31. ncbi request reprint The experience of cancer-related fatigue and chronic fatigue syndrome: a qualitative and comparative study
    Barbara Bennett
    Department of Medical Oncology, Prince of Wales Hospital, Sydney, Australia
    J Pain Symptom Manage 34:126-35. 2007
    ..Qualitatively, CRF appears closely related to CFS. These findings raise the emergent hypothesis of a conserved neurobehavioral symptom complex, which results from diverse triggering insults...
  32. doi request reprint Key role of pancreatic stellate cells in pancreatic cancer
    Srinivasa P Pothula
    Pancreatic Research Group, South Western Sydney Clinical School, Faculty of Medicine, The University of New South Wales, Sydney, Australia Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia
    Cancer Lett 381:194-200. 2016
    ..A multi-pronged approach aimed at tumour cells as well as stromal elements may be the key to achieving better clinical outcomes in patients with pancreatic cancer. ..
  33. doi request reprint Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial
    William Greenhalf
    Affiliations of authors Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool, Liverpool, UK WG, JPN, Eg, TFC, PG, EC, CMH, CLR, FC, RJ the Princess Margaret Hospital, Toronto, Canada MJM Manchester Academic Health Sciences Centre, Christie NHS Foundation Trust, School of Cancer and enabling Sciences, University of Manchester, UK JWV Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK DHP Beatson West of Scotland Cancer Centre, Glasgow, UK ACM Glasgow Royal Infirmary, Glasgow, UK RC Hôpital Tenon, Universite, Pierre et Marie Curie, Paris, France FL Austin Health, Melbourne, Australia NCT Prince of Wales Hospital and Clinical School University of New South Wales, New South Wales, Australia DG Nepean Cancer Centre and University of Sydney, Sydney, Australia JS Agia Olga Hospital, Athens, Seong Nam
    J Natl Cancer Inst 106:djt347. 2014
    ..Human equilibrative nucleoside transporter 1 (hENT1) levels in pancreatic adenocarcinoma may predict survival in patients who receive adjuvant gemcitabine after resection...
  34. pmc Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    Daniel D Von Hoff
    From the Translational Genomics Research Institute, Phoenix, and Virginia G Piper Cancer Center, Scottsdale both in Arizona D D V H, R K R Cancer Specialists, Fort Myers, FL T E Arena Oncology Associates, Lake Success F P A, and Roswell Park Cancer Institute, Buffalo W W M both in New York University of Washington, Seattle E G C Sarah Cannon Research Institute Tennessee Oncology, Nashville J Infante Princess Margaret Hospital, Toronto M M Atlanta Cancer Care T S and Georgia Cancer Specialists M N S both in Atlanta Blokhin Cancer Research Center, Moscow S A T Southern Health, East Bentleigh, VIC M H, Prince of Wales Hospital, Sydney D G, and Bionomics, Thebarton, SA J Iglesias all in Australia San Raffaele Scientific Institute, Milan M R Tom Baker Cancer Centre, Calgary, AB, Canada S D Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore D L University of Pittsburgh Medical Center, Pittsburgh N B Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona J T Centro Integral Oncológico Clara Campal, Madrid M H University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven, Belgium E V C and Celgene, Summit, NJ X W, M F R
    N Engl J Med 369:1691-703. 2013
    ..We conducted a phase 3 study of the efficacy and safety of the combination versus gemcitabine monotherapy in patients with metastatic pancreatic cancer...
  35. pmc Tumor Reduction in Primary and Metastatic Pancreatic Cancer Lesions With nab-Paclitaxel and Gemcitabine: An Exploratory Analysis From a Phase 3 Study
    Volker Kunzmann
    From the Medizinische Klinik und Poliklinik II, University of Wurzburg, Wurzburg, Germany Mayo Clinic, Scottsdale, AZ Prince of Wales Hospital, Sydney, New South Wales, Australia Celgene Corporation, Summit, NJ and Translational German Research Institute and Honor Health Research Institute, Scottsdale, AZ
    Pancreas . 2016
    ..The current analysis evaluated the effects of nab-paclitaxel plus gemcitabine versus gemcitabine on primary pancreatic and metastatic lesions...
  36. doi request reprint Cognitive functioning after radiotherapy or chemoradiotherapy for head-and-neck cancer
    Hui K Gan
    Department of Medical Oncology, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 81:126-34. 2011
    ..To perform a comprehensive cognitive function (CF) assessment in patients who were relapse free after curative intent radiotherapy (RT) or chemoradiotherapy for squamous cell carcinoma of the head and neck...
  37. doi request reprint Impact of gemcitabine chemotherapy and 3-dimensional conformal radiation therapy/5-fluorouracil on quality of life of patients managed for pancreatic cancer
    Michala Short
    Discipline of Medical Radiation Sciences, University of Sydney, and Department of Medical Oncology, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Int J Radiat Oncol Biol Phys 85:157-62. 2013
    ..To report quality of life (QOL) results for patients receiving chemoradiation therapy for pancreatic cancer...
  38. pmc If I am in the mood, I enjoy it: an exploration of cancer-related fatigue and sexual functioning in women with breast cancer
    Kate Webber
    Department of Medical Oncology, Prince of Wales Hospital, High Street, Randwick, New South Wales 2031, Australia
    Oncologist 16:1333-44. 2011
    ..The current paper describes sexual functioning (SF) and its relationship to CRF, mood disorder, and quality of life (QOL) over the first year after completion of adjuvant therapy...
  39. pmc Fatigue states after cancer treatment occur both in association with, and independent of, mood disorder: a longitudinal study
    David Goldstein
    Department of Medical Oncology, Prince of Wales Hospital, Sydney, Australia
    BMC Cancer 6:240. 2006
    ..We sought to examine the longitudinal relationships between fatigue and mood disorder in women treated with adjuvant therapy for early stage breast cancer...
  40. doi request reprint The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: antiangiogenic implications in pancreatic cancer
    Mishaal B Patel
    Pancreatic Research Group, South Western Sydney Clinical School, Ingham Institute for Applied Medical Research and the School of Medical Sciences, University of New South Wales, Sydney, New South Wales 2170, Australia
    Carcinogenesis 35:1891-900. 2014
    ....
  41. pmc Prognostic factors of survival in a randomized phase III trial (MPACT) of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic pancreatic cancer
    Josep Tabernero
    Medical Oncology Department, Vall d Hebron University Hospital and Institute of Oncology, Universitat Autonoma de Barcelona, Barcelona, Spain Division of Oncology, University of Washington, Seattle, Washington, USA Department of Oncology Hematology, Sarah Cannon Research Institute, Nashville, Tennessee, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Department of Oncology, Peninsula Oncology Centre, Monash University, Frankston, Victoria, Australia Division of Medical Oncology, University of Colorado Cancer Center, Aurora, Colorado, USA Division of Clinical Oncology, Medizinische Universität Wien, Vienna, Austria Mayo Clinic, Scottsdale, Arizona, USA Department of Oncology, Prince of Wales Hospital, Randwick, New South Wales, Sydney, Australia Celgene Corporation, Summit, New Jersey, USA Department of Oncology, Virginia G Piper Cancer Center at Scottsdale Healthcare TGen, Scottsdale, Arizona, USA
    Oncologist 20:143-50. 2015
    ..This analysis sought to further explore the relationship between clinical characteristics and survival in the MPACT trial and to identify potential predictors of overall survival and progression-free survival in patients with MPC...
  42. doi request reprint Psychological morbidity and quality of life of ethnic minority patients with cancer: a systematic review and meta-analysis
    Tim Luckett
    Psycho oncology Co operative Research Group, University of Sydney, Sydney, NSW, Australia
    Lancet Oncol 12:1240-8. 2011
    ..We did a systematic review and meta-analysis to assess whether psychological morbidity and health-related quality of life (HRQoL) were affected by minority status...
  43. ncbi request reprint Enhancing psychosocial care for people with cancer in rural communities: what can remote counselling offer?
    Louise Shepherd
    Counselling Service, University of New South Wales, East Wing, Quadrangle Building, Kensington Campus, Sydney NSW 2052, Australia
    Aust Health Rev 32:423-38. 2008
    ..Where no face-to-face psychological service exists, these technologies are promising, yet unproven. Less variable methods are needed to better assess the technology and therapeutic approach for stronger evidence...
  44. ncbi request reprint Clinical supervision and education via videoconference: a feasibility project
    Kristina Xavier
    Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW, Australia
    J Telemed Telecare 13:206-9. 2007
    ..3 out of 10). With regard to telephone supervision, most (80%) were very or extremely satisfied. The feedback indicated that remote supervision was well received and that participants were keen to continue their involvement...
  45. doi request reprint Uncovering a key to the process of metastasis in human cancers: a review of critical regulators of anoikis
    Kevin Tan
    Adult Cancer Program, Sarcoma and Nano Oncology Research Group, Faculty of Medicine, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Room 209, Sydney, NSW, 2052, Australia
    J Cancer Res Clin Oncol 139:1795-805. 2013
    ..Consequently, the identification of key regulators of anoikis that can be targeted to at least partially restore anoikis sensitivity in cancer cells is important in the development of therapies to treat metastatic cancer...
  46. doi request reprint Pancreatic stellate cells: partners in crime with pancreatic cancer cells
    Alain Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School, The University of New South Wales, Sydney, New South Wales 2052, Australia
    Cancer Res 68:2085-93. 2008
    ..Our studies indicate a significant interaction between pancreatic cancer cells and stromal cells (PSCs) and imply that pancreatic cancer cells recruit stromal cells to establish an environment that promotes cancer progression...
  47. doi request reprint Fixed-dose-rate gemcitabine combined with cisplatin in patients with inoperable biliary tract carcinomas
    David Goldstein
    Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW, Australia
    Cancer Chemother Pharmacol 67:519-25. 2011
    ..Biliary tract cancers (BTC) have a poor prognosis, and there is no consensus on the best chemotherapy regimen. This study determined the response rate for fixed-dose-rate (FDR) gemcitabine combined with cisplatin...
  48. pmc Overcoming resistance of targeted EGFR monotherapy by inhibition of STAT3 escape pathway in soft tissue sarcoma
    Xiaochun Wang
    Department of Surgery, Adult Cancer Program, Lowy Cancer Research Centre, Clinical School of Prince of Wales Hospital, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Oncotarget 7:21496-509. 2016
    ..Our findings may have clinical implications for optimising EGFR-targeted therapy in STS. ..
  49. ncbi request reprint Targeting the PI3K/PTEN/AKT/mTOR Pathway in Treatment of Sarcoma Cell Lines
    Hui Jun Lim
    Sarcoma and Nano oncology Group, Adult Cancer Program, Lowy Cancer Research Centre, Department of Medical Oncology and Surgery, Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Randwick, NSW, Australia
    Anticancer Res 36:5765-5771. 2016
    ..The aims of this study were to characterise PTEN and Akt expression in a panel of sarcoma cell lines and then to examine mTOR inhibition using ridaforolimus...
  50. doi request reprint STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (review)
    Xiaochun Wang
    Sarcoma Research Group, Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW, Australia
    Int J Oncol 41:1181-91. 2012
    ..Targeting STAT3 using a specific inhibitor may be a useful cancer treatment approach, with the potential for a broad clinical impact...
  51. ncbi request reprint Impact of STAT3 inhibition on survival of osteosarcoma cell lines
    Xiaochun Wang
    Sarcoma Research Group, Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Randwick, Australia Department of Surgery, Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Randwick, Australia
    Anticancer Res 34:6537-45. 2014
    ..Constitutive STAT3 activation is associated with various human cancers and commonly suggests poor prognosis. We aimed to investigate the effect and potential molecular mechanisms of STAT3 inhibition on osteosarcoma...
  52. doi request reprint Describing Patterns of Care in Pancreatic Cancer: A Population-Based Study
    Elizabeth A Burmeister
    From the Population Health, QIMR Berghofer Medical Research Institute University of Queensland, Brisbane, Queensland Cancer Research Division, Cancer Council NSW, Sydney University of Newcastle, Newcastle Department of Medical Oncology, Prince of Wales Hospital University of New South Wales Sydney Nursing School, University of Sydney, Sydney, New South Wales Queensland University of Technology, Brisbane, Queensland School of Medicine, University of Western Sydney, Sydney, New South Wales and Department of Medical Oncology, Royal Brisbane and Women s Hospital, Brisbane, Queensland
    Pancreas 44:1259-65. 2015
    ..The objective of this study was to reflect on current practice and outcomes to facilitate future improvement...
  53. doi request reprint Targeted therapy in soft tissue sarcoma-a novel direction in therapeutics
    Chun Jek Tan
    Sarcoma Research Group, Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Surgery, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    Chin Clin Oncol 2:22. 2013
    ..This review examines the potential for tactical combinations of these drugs to overcome this problem. ..
  54. ncbi request reprint The utility of videoconferencing to provide innovative delivery of psychological treatment for rural cancer patients: results of a pilot study
    Louise Shepherd
    Department of Medical Oncology, Prince of Wales Hospital, Randwick, New South Wales, Australia
    J Pain Symptom Manage 32:453-61. 2006
    ..01) and quality of life (P=0.04). The service was both practical and acceptable. These preliminary positive results provide a firm basis to conduct a randomized controlled trial of face-to-face interaction vs. videoconferencing...
  55. doi request reprint From inside the bubble: migrants' perceptions of communication with the cancer team
    Phyllis N Butow
    Psycho oncology Co operative Research Group, University of Sydney, Sydney, NSW, Australia
    Support Care Cancer 19:281-90. 2010
    ..In this paper, the findings related to communication issues are presented...
  56. ncbi request reprint Effect of sertraline on symptoms and survival in patients with advanced cancer, but without major depression: a placebo-controlled double-blind randomised trial
    Martin R Stockler
    NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia
    Lancet Oncol 8:603-12. 2007
    ..We aimed to identify the effects of an established antidepressant on these symptoms and survival in patients with advanced cancer who did not have major depression as assessed by clinicians...
  57. doi request reprint Communicating with patients from minority backgrounds: Individual challenges experienced by oncology health professionals
    Kaaren J Watts
    Prince of Wales Clinical School, The University of New South Wales, Sydney, NSW 2052, Australia
    Eur J Oncol Nurs 26:83-90. 2017
    ..This qualitative study aimed to identify oncology nurses' and oncologists' individual experiences and challenges in communicating with patients from minority backgrounds...
  58. ncbi request reprint Characterization of fatigue States in medicine and psychiatry by structured interview
    Barbara Kaye Bennett
    From the Department of Medical Oncology B K B, M C, D G, Prince of Wales Hospital, Sydney, Australia Brain and Mind Research Institute T A D, E M S, I B H, The University of Sydney, Sydney, Australia School of Psychiatry U V C, Inflammation and Infection Research Centre, School of Medical Sciences A R L, and New South Wales Cancer Survivors Centre B K B, D G, A R L, The University of New South Wales, Sydney, Australia
    Psychosom Med 76:379-88. 2014
    ..Unexplained fatigue states are prevalent, with uncertain diagnostic boundaries...
  59. ncbi request reprint Oxaliplatin and axonal Na+ channel function in vivo
    Arun V Krishnan
    Institute of Neurological Sciences, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Clin Cancer Res 12:4481-4. 2006
    ..The aim of the study was to investigate the pathophysiology of oxaliplatin-induced neurotoxicity using clinical nerve excitability techniques that provide information about axonal ion channel function...
  60. pmc A serious complication of selected internal radiation therapy: case report and literature review
    Katrin M Sjoquist
    Department of Medical Oncology, Prince of Wales Hospital, High Street, Randwick, NSW Australia
    Oncologist 15:830-5. 2010
    ..The characteristic endoscopic, radiologic, and histopathologic findings are illustrated and recommendations are reviewed with regard to the current literature...
  61. doi request reprint It's all good on the surface: care coordination experiences of migrant cancer patients in Australia
    Joanne M Shaw
    School of Psychology, The University of Sydney, Sydney, NSW, Australia
    Support Care Cancer 24:2403-10. 2016
    ....
  62. ncbi request reprint Erlotinib (OSI-774)-induced inhibition of transitional cell carcinoma of bladder cell line growth is enhanced by interferon-alpha
    Jia Lin Yang
    Oncology Research Centre, Prince of Wales Hospital, Department of Clinical Medicine, University of New South Wales, Sydney, Australia
    BJU Int 99:1539-45. 2007
    ....
  63. doi request reprint Motesanib with or without panitumumab plus FOLFIRI or FOLFOX for the treatment of metastatic colorectal cancer
    Niall Tebbutt
    Department of Medical Oncology, Austin Health, Heidelberg, Vic, 3084, Australia
    Cancer Chemother Pharmacol 75:993-1004. 2015
    ....
  64. pmc Primary pancreatic lymphoma--pancreatic tumours that are potentially curable without resection, a retrospective review of four cases
    Peter S Grimison
    Institute of Oncology, Prince of Wales Hospital, Sydney, Australia
    BMC Cancer 6:117. 2006
    ..Symptoms, imaging and tumour markers can mimic pancreatic adenocarcinoma, but they are much more amenable to treatment. Treatment for PPL remains controversial, particularly the role of surgical resection...