Gerald L Murray

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. doi request reprint The molecular basis of leptospiral pathogenesis
    Gerald L Murray
    Department of Microbiology, Monash University, Melbourne, Australia
    Curr Top Microbiol Immunol 387:139-85. 2015
  2. doi request reprint The lipoprotein LipL32, an enigma of leptospiral biology
    Gerald L Murray
    Department of Microbiology, Monash University, Victoria 3800, Australia
    Vet Microbiol 162:305-14. 2013
  3. pmc High-temperature protein G is an essential virulence factor of Leptospira interrogans
    Amy M King
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Victoria, Australia
    Infect Immun 82:1123-31. 2014
  4. doi request reprint Recombinant LipL32 stimulates interferon-gamma production in cattle vaccinated with a monovalent Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis vaccine
    Deanna S Deveson Lucas
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Departments of Microbiology and Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia
    Vet Microbiol 169:163-70. 2014
  5. pmc Leptospiral LruA is required for virulence and modulates an interaction with mammalian apolipoprotein AI
    Kunkun Zhang
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Victoria, Australia
    Infect Immun 81:3872-9. 2013
  6. pmc Leptospiral outer membrane protein LipL41 is not essential for acute leptospirosis but requires a small chaperone protein, lep, for stable expression
    Amy M King
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Infect Immun 81:2768-76. 2013
  7. doi request reprint Evaluation of 238 antigens of Leptospira borgpetersenii serovar Hardjo for protection against kidney colonisation
    Gerald L Murray
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Departments of Microbiology and Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Vaccine 31:495-9. 2013
  8. doi request reprint Use of a high-throughput screen to identify Leptospira mutants unable to colonize the carrier host or cause disease in the acute model of infection
    Renee A Marcsisin
    1Department of Microbiology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    J Med Microbiol 62:1601-8. 2013
  9. doi request reprint Leptospira interrogans requires heme oxygenase for disease pathogenesis
    Gerald L Murray
    Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, VIC 3800, Australia
    Microbes Infect 11:311-4. 2009
  10. doi request reprint Pathogenesis of leptospirosis: the influence of genomics
    Ben Adler
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Australia
    Vet Microbiol 153:73-81. 2011

Collaborators

Detail Information

Publications19

  1. doi request reprint The molecular basis of leptospiral pathogenesis
    Gerald L Murray
    Department of Microbiology, Monash University, Melbourne, Australia
    Curr Top Microbiol Immunol 387:139-85. 2015
    ..While many advances have been made, there remains a lack of understanding of how Leptospira causes tissue pathology. It is likely that leptospires have many novel pathogenesis mechanisms that are yet to be identified. ..
  2. doi request reprint The lipoprotein LipL32, an enigma of leptospiral biology
    Gerald L Murray
    Department of Microbiology, Monash University, Victoria 3800, Australia
    Vet Microbiol 162:305-14. 2013
    ..Further work is clearly required to fully elucidate the role of this protein in the biology of Leptospira...
  3. pmc High-temperature protein G is an essential virulence factor of Leptospira interrogans
    Amy M King
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Victoria, Australia
    Infect Immun 82:1123-31. 2014
    ..The underlying cause for attenuation thus remains unknown, but HtpG is a novel leptospiral virulence factor and one of only a very small number identified to date. ..
  4. doi request reprint Recombinant LipL32 stimulates interferon-gamma production in cattle vaccinated with a monovalent Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis vaccine
    Deanna S Deveson Lucas
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Departments of Microbiology and Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia
    Vet Microbiol 169:163-70. 2014
    ..However, whether LipL32 plays a role in stimulating protective immunity in mammals has yet to be conclusively determined...
  5. pmc Leptospiral LruA is required for virulence and modulates an interaction with mammalian apolipoprotein AI
    Kunkun Zhang
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Victoria, Australia
    Infect Immun 81:3872-9. 2013
    ..Our data thus identify LruA as a surface-exposed leptospiral virulence factor that contributes to leptospiral pathogenesis, possibly by modulating cellular interactions with serum protein ApoA-I. ..
  6. pmc Leptospiral outer membrane protein LipL41 is not essential for acute leptospirosis but requires a small chaperone protein, lep, for stable expression
    Amy M King
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Infect Immun 81:2768-76. 2013
    ..The roles of LipL41 and Lep in the pathogenesis of Leptospira interrogans were investigated; surprisingly, neither of these two unique proteins was essential for acute leptospirosis. ..
  7. doi request reprint Evaluation of 238 antigens of Leptospira borgpetersenii serovar Hardjo for protection against kidney colonisation
    Gerald L Murray
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Departments of Microbiology and Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Vaccine 31:495-9. 2013
    ..It thus constitutes an important reference of protein immunogenicity and non-protective antigens that should be consulted before embarking on any future subunit vaccine experiments...
  8. doi request reprint Use of a high-throughput screen to identify Leptospira mutants unable to colonize the carrier host or cause disease in the acute model of infection
    Renee A Marcsisin
    1Department of Microbiology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    J Med Microbiol 62:1601-8. 2013
    ..A comparison of virulence factors required in the carrier and acute models of infection will help to unravel colonization and dissemination mechanisms of leptospirosis. ..
  9. doi request reprint Leptospira interrogans requires heme oxygenase for disease pathogenesis
    Gerald L Murray
    Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, VIC 3800, Australia
    Microbes Infect 11:311-4. 2009
    ..interrogans. This is only the second defined, attenuated mutant in pathogenic Leptospira and the first to define function of the mutated gene...
  10. doi request reprint Pathogenesis of leptospirosis: the influence of genomics
    Ben Adler
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Australia
    Vet Microbiol 153:73-81. 2011
    ....
  11. pmc Transcriptional response of Leptospira interrogans to iron limitation and characterization of a PerR homolog
    Miranda Lo
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Infect Immun 78:4850-9. 2010
    ..Our results provide insights into the role of iron in leptospiral metabolism and regulation of the oxidative stress response, including genes likely to be important for virulence...
  12. doi request reprint Mutations affecting Leptospira interrogans lipopolysaccharide attenuate virulence
    Gerald L Murray
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Mol Microbiol 78:701-9. 2010
    ..While complementation of mutants was not possible, the attenuation of two independently derived LPS mutants demonstrates for the first time that LPS plays an essential role leptospiral virulence...
  13. pmc Precipitation of iron on the surface of Leptospira interrogans is associated with mutation of the stress response metalloprotease HtpX
    Rebekah Henry
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Appl Environ Microbiol 79:4653-60. 2013
    ..Combining these findings, this report describes OMV production in response to environmental stressors and associates OMV production with the in vitro activity of an HtpX-like metalloprotease. ..
  14. pmc Genome-wide transposon mutagenesis in pathogenic Leptospira species
    Gerald L Murray
    Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, VIC 3800, Australia
    Infect Immun 77:810-6. 2009
    ..interrogans. Combined with the genome sequences of L. interrogans, this provides an opportunity to investigate genes that contribute to pathogenesis and will provide a better understanding of the biology of L. interrogans...
  15. pmc Use of luminescent Leptospira interrogans for enumeration in biological assays
    Gerald L Murray
    Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia
    J Clin Microbiol 48:2037-42. 2010
    ....
  16. doi request reprint Crystal structure of LipL32, the most abundant surface protein of pathogenic Leptospira spp
    Julian P Vivian
    The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    J Mol Biol 387:1229-38. 2009
    ..Moreover, the structure provides a framework for understanding the immunological role of this major surface lipoprotein...
  17. pmc Impact of a Cross-Kingdom Signaling Molecule of Candida albicans on Acinetobacter baumannii Physiology
    Xenia Kostoulias
    Department of Microbiology, Monash University, Melbourne, Australia
    Antimicrob Agents Chemother 60:161-7. 2015
    ..These data provide mechanistic understanding of the antagonistic interactions between diverse pathogens and may provide important insights into novel therapeutic strategies. ..
  18. pmc Major surface protein LipL32 is not required for either acute or chronic infection with Leptospira interrogans
    Gerald L Murray
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Infect Immun 77:952-8. 2009
    ..and its absence in saprophytic Leptospira, this finding is remarkable. The role of this protein in leptospiral biology and pathogenesis thus remains elusive...
  19. doi request reprint Identification of genes essential for leptospirosis
    Thanatchaporn Bartpho
    Department of Microbiology, Monash University, Clayton, Vic, Australia
    Methods Mol Biol 1279:67-77. 2015
    ....