David T Manallack

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. doi request reprint The Acid/Base Profile of the Human Metabolome and Natural Products
    David T Manallack
    Medicinal Chemistry and Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia tel 61 3 99039537
    Mol Inform 32:505-15. 2013
  2. pmc A chemogenomic analysis of ionization constants--implications for drug discovery
    David T Manallack
    Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia
    ChemMedChem 8:242-55. 2013
  3. pmc The significance of acid/base properties in drug discovery
    David T Manallack
    Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia
    Chem Soc Rev 42:485-96. 2013
  4. doi request reprint Homology modeling of human muscarinic acetylcholine receptors
    Trayder Thomas
    Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052 Australia
    J Chem Inf Model 54:243-53. 2014

Collaborators

  • Tudor I Oprea
  • Trayder Thomas
  • Kimberley C McLean
  • Elizabeth Yuriev
  • Fiona M McRobb
  • David K Chalmers

Detail Information

Publications4

  1. doi request reprint The Acid/Base Profile of the Human Metabolome and Natural Products
    David T Manallack
    Medicinal Chemistry and Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia tel 61 3 99039537
    Mol Inform 32:505-15. 2013
    ..Considering also that the non-lipid metabolites are of biochemical interest, their characteristics have great potential to influence the selection of screening compounds for drug discovery. ..
  2. pmc A chemogenomic analysis of ionization constants--implications for drug discovery
    David T Manallack
    Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia
    ChemMedChem 8:242-55. 2013
    ..Our analysis provides a guide for the selection of screening compounds to better target specific chemogenomic families with regard to the overall balance of acids, bases and pK(a) distributions...
  3. pmc The significance of acid/base properties in drug discovery
    David T Manallack
    Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia
    Chem Soc Rev 42:485-96. 2013
    ..Given the recent low annual output of new drugs from pharmaceutical companies, this review will provide a timely reminder of an important molecular property that influences clinical success...
  4. doi request reprint Homology modeling of human muscarinic acetylcholine receptors
    Trayder Thomas
    Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052 Australia
    J Chem Inf Model 54:243-53. 2014
    ....