Martin Lackmann

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. pmc PTP1B regulates Eph receptor function and trafficking
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Cell Biol 191:1189-203. 2010
  2. pmc Recruitment of Eph receptors into signaling clusters does not require ephrin contact
    Sabine H Wimmer-Kleikamp
    Dept of Biochemistry and Molecular Biology, P O Box 13D, Monash University, Clayton, Victoria 3800, Australia
    J Cell Biol 164:661-6. 2004
  3. pmc Expression of nodal signalling components in cycling human endometrium and in endometrial cancer
    Irene Papageorgiou
    Prince Henry s Institute of Medical Research, 246 Clayton Road, Clayton, VIC 3168, Australia
    Reprod Biol Endocrinol 7:122. 2009
  4. ncbi request reprint Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents
    Christopher Vearing
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Cancer Res 65:6745-54. 2005
  5. doi request reprint Eph, a protein family coming of age: more confusion, insight, or complexity?
    Martin Lackmann
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Sci Signal 1:re2. 2008
  6. doi request reprint Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells
    Sabine H Wimmer-Kleikamp
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    Blood 112:721-32. 2008
  7. pmc Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function
    Lakmali Atapattu
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    J Cell Sci 125:6084-93. 2012
  8. pmc Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth
    Catherine To
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
    PLoS ONE 9:e112106. 2014
  9. ncbi request reprint Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
    Peter W Janes
    Department of Biochemistry and Molecular Biology, PO Box 13D, Monash University, Victoria 3800, Australia
    Cell 123:291-304. 2005
  10. doi request reprint Eph-dependent cell-cell adhesion and segregation in development and cancer
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Vic, 3800, Australia
    Cell Mol Life Sci 69:1813-42. 2012

Collaborators

  • Dimitar B Nikolov
  • Andrew M Scott
  • Shahin Rafii
  • Zhanqi Liu
  • Kai Xu
  • Fawaz G Haj
  • Tony Pawson
  • Bryan W Day
  • Paul Saftig
  • Peter W Janes
  • Eva Nievergall
  • Lakmali Atapattu
  • Mary E Vail
  • Carmen Llerena
  • Sabine H Wimmer-Kleikamp
  • Andrew W Boyd
  • Chanly Chheang
  • Mariam Mansour
  • Nayanendu Saha
  • Catherine To
  • Philippe I Bastiaens
  • Christopher Vearing
  • Linda Hii
  • Carmel Murone
  • Rotem Aharon
  • Kristina Gegenbauer
  • Juha Pekka Himanen
  • Bettina Griesshaber
  • Fook Thean Lee
  • Irene Papageorgiou
  • Samantha Adikari
  • Christopher J Vearing
  • William A Barton
  • Fiona M Smith
  • Con Stylianou
  • Helen E Abud
  • Moritz F Eissman
  • Katja Horvay
  • Matthias Ernst
  • Zhongwei Cao
  • Bi Sen Ding
  • Robert L Moritz
  • Maxime Halle
  • Ulrike Kusebauch
  • Michel L Tremblay
  • Degu Abebe
  • Fima Klebaner
  • Glenn Cartwright
  • Rae H Farnsworth
  • Varghese Palath
  • April Tan
  • Kais Hamza
  • Christopher Bebbington
  • Slavisa Garic
  • Anthony W Burgess
  • David Abramson
  • Michelle Down
  • Mark G Coulthard
  • Isobel D Lawrenson
  • Mark Baer
  • Caroline E Gargett
  • Geoffrey Yarranton
  • Andrew T Major
  • Thomas Saunders
  • Linda L Hii
  • Claus Jørgensen
  • Anneloes Mensinga
  • Shyh Wei Teng
  • Benjamin G Neel
  • Carolin Stegmayer
  • Yogeshwar Makanji
  • Craig A Harrison
  • Lois A Salamonsen
  • Peter K Nicholls
  • Kane Treble
  • Fang Wang
  • Alice Y Ting
  • Markus Grabenbauer
  • Achilleas S Frangakis
  • David M Robertson
  • Ola Sabet
  • Neill R Patani
  • Trina Yeadon
  • Mark Spanevello
  • Martin Brechbiel
  • Violeta Spirkoska
  • Carl P Blobel
  • Momchil V Kolev
  • Sabine Wimmer-Kleikamp
  • Mark Henkemeyer

Detail Information

Publications26

  1. pmc PTP1B regulates Eph receptor function and trafficking
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Cell Biol 191:1189-203. 2010
    ..Our studies for the first time provide molecular, mechanistic, and functional insights into the role of PTP1B controlling Eph/ephrin-facilitated cellular interactions...
  2. pmc Recruitment of Eph receptors into signaling clusters does not require ephrin contact
    Sabine H Wimmer-Kleikamp
    Dept of Biochemistry and Molecular Biology, P O Box 13D, Monash University, Clayton, Victoria 3800, Australia
    J Cell Biol 164:661-6. 2004
    ....
  3. pmc Expression of nodal signalling components in cycling human endometrium and in endometrial cancer
    Irene Papageorgiou
    Prince Henry s Institute of Medical Research, 246 Clayton Road, Clayton, VIC 3168, Australia
    Reprod Biol Endocrinol 7:122. 2009
    ..Nodal, a member of the transforming growth factor-beta superfamily, regulates the processes of pattern formation and differentiation that occur during early embryo development...
  4. ncbi request reprint Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents
    Christopher Vearing
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Cancer Res 65:6745-54. 2005
    ..These findings show the biological importance of EphA3/ephrin-A5 interactions and that ephrin-A5 and IIIA4 have great potential as tumor targeting reagents...
  5. doi request reprint Eph, a protein family coming of age: more confusion, insight, or complexity?
    Martin Lackmann
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Sci Signal 1:re2. 2008
    ..Undeniably, the complexity of the underlying signaling networks is considerable, and it seems probable that systems biology approaches are required to further improve our understanding of Eph function...
  6. doi request reprint Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells
    Sabine H Wimmer-Kleikamp
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    Blood 112:721-32. 2008
    ....
  7. pmc Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function
    Lakmali Atapattu
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    J Cell Sci 125:6084-93. 2012
    ....
  8. pmc Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth
    Catherine To
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
    PLoS ONE 9:e112106. 2014
    ....
  9. ncbi request reprint Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
    Peter W Janes
    Department of Biochemistry and Molecular Biology, PO Box 13D, Monash University, Victoria 3800, Australia
    Cell 123:291-304. 2005
    ..Our data suggest a simple mechanism for regulating ADAM10-mediated ephrin proteolysis, which ensures that only Eph bound ephrins are recognized and cleaved...
  10. doi request reprint Eph-dependent cell-cell adhesion and segregation in development and cancer
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Vic, 3800, Australia
    Cell Mol Life Sci 69:1813-42. 2012
    ..This review summarises our current understanding of how Eph receptors control cell adhesion and morphology, and presents examples demonstrating the importance of these events in normal development and cancer...
  11. pmc Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10
    Peter W Janes
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    PLoS Biol 7:e1000215. 2009
    ..Our data suggest that this phosphorylation-activated conformational switch of EphA3 directly controls ADAM-mediated shedding...
  12. doi request reprint PTP-PEST controls EphA3 activation and ephrin-induced cytoskeletal remodelling
    Mariam Mansour
    Cancer Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800 Victoria, Australia
    J Cell Sci 129:277-89. 2016
    ..We conclude that PTP-PEST regulates EphA3 activation both by affecting cytoskeletal remodelling and through its direct action as a PTP controlling EphA3 phosphorylation, indicating its multifaceted regulation of Eph signalling. ..
  13. pmc An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth
    Lakmali Atapattu
    Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Exp Med 213:1741-57. 2016
    ..Our results indicate targeted inhibition of active ADAM10 as a potential therapy for ADAM10-dependent tumor development and drug resistance. ..
  14. ncbi request reprint Eph/ephrin signalling and function in oncogenesis: lessons from embryonic development
    Peter W Janes
    Department of Biochemistry and Molecular Biology, PO Box 13D, Monash University, Victoria 3800, Australia
    Curr Cancer Drug Targets 8:473-9. 2008
    ....
  15. pmc Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors
    Peter W Janes
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    J Cell Biol 195:1033-45. 2011
    ..Importantly, they imply that in tumor cells coexpressing different Ephs, functional mutations in one subtype may cause phenotypes that are a result of altered signaling from heterotypic rather from homotypic Eph clusters...
  16. ncbi request reprint Targeting of EPH receptor tyrosine kinases for anticancer therapy
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Crit Rev Oncog 17:211-32. 2012
    ....
  17. doi request reprint Concepts and consequences of Eph receptor clustering
    Peter W Janes
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Victoria 3800, Australia
    Semin Cell Dev Biol 23:43-50. 2012
    ....
  18. doi request reprint Targeting EphA3 inhibits cancer growth by disrupting the tumor stromal microenvironment
    Mary E Vail
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Cancer Res 74:4470-81. 2014
    ..Our data define EphA3 as a novel target for selective ablation of the tumor microenvironment and demonstrate the potential of EphA3 agonists for anticancer therapy...
  19. pmc A mathematical model for eph/ephrin-directed segregation of intermingled cells
    Rotem Aharon
    School of Mathematical Sciences, Monash University, Clayton, Victoria, Australia
    PLoS ONE 9:e111803. 2014
    ..This model allows reliable prediction of Eph/ephrin-dependent control of cell patterning behaviour. ..
  20. ncbi request reprint "Eph receptor signalling; dimerisation just isn't enough"
    Christopher J Vearing
    Department of Biochemistry and Molecular Biology, Monash University, Australia
    Growth Factors 23:67-76. 2005
  21. pmc Crystal structure of the human ephrin-A5 ectodomain
    Dimitar Nikolov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Protein Sci 16:996-1000. 2007
    ..The results of this study further emphasize the importance of the G-H loop for receptor recognition and selectivity, and could serve as a starting point for the development of structure-based Eph antagonists...
  22. ncbi request reprint Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
    Isobel D Lawrenson
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Sci 115:1059-72. 2002
    ....
  23. ncbi request reprint Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3
    Bryan Day
    Queensland Institute of Medical Research, P O Royal Brisbane Hospital 4029, Queensland, Australia
    J Biol Chem 280:26526-32. 2005
    ....
  24. ncbi request reprint Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
    Juha Pekka Himanen
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Neurosci 7:501-9. 2004
    ..The structural data reveal the molecular basis for EphB2-ephrin-A5 signaling and provide a framework for understanding the complexities of functional interactions and crosstalk between A- and B-subclass Eph receptors and ephrins...
  25. ncbi request reprint Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen
    Fiona M Smith
    Leukaemia Foundation of Queensland Laboratory, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Queensland 4029, Australia
    J Biol Chem 279:9522-31. 2004
    ..Functional analysis of EphA3 mutants reveals that all three Eph/ephrin contact areas are essential for the assembly of signaling-competent, oligomeric receptor-ligand complexes...
  26. ncbi request reprint The role of the Eph-ephrin signalling system in the regulation of developmental patterning
    Mark G Coulthard
    Leukaemia Foundation Laboratory, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Australia
    Int J Dev Biol 46:375-84. 2002
    ..This review focuses on two vertebrate models, the zebrafish and mouse, in which experimental perturbation of Eph and/or ephrin expression in vivo have provided important insights into the role and functioning of the Eph/ephrin system...