Ashley I Bush

Summary

Affiliation: Mental Health Research Institute
Country: Australia

Publications

  1. doi Kalzium ist nicht alles
    Ashley I Bush
    Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Neuron 65:143-4. 2010
  2. ncbi Drug development based on the metals hypothesis of Alzheimer's disease
    Ashley I Bush
    The Mental Health Research Institute of Victoria, Parkville, Vic, Australia
    J Alzheimers Dis 15:223-40. 2008
  3. doi Decline in cognitive function over 18 months in healthy older adults with high amyloid-β
    Kathryn A Ellis
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 34:861-71. 2013
  4. doi Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Neuron 59:43-55. 2008
  5. doi Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease
    Alan Rembach
    The Mental Health Research Institute, The University of Melbourne, Vic, Australia
    J Alzheimers Dis 34:171-82. 2013
  6. pmc Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute, Parkville, Victoria, Australia
    PLoS ONE 6:e17669. 2011
  7. doi BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neurobiol Aging 34:2457-64. 2013
  8. doi Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats
    Kwok Ho Christopher Choy
    Mental Health Research Institute, Parkville, Victoria, Australia
    Eur J Pharmacol 649:224-8. 2010
  9. doi Cognitive consequences of high Aβ amyloid in mild cognitive impairment and healthy older adults: implications for early detection of Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neuropsychology 27:322-32. 2013
  10. pmc Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease
    Ya Hui Hung
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    J Biol Chem 284:21899-907. 2009

Detail Information

Publications78

  1. doi Kalzium ist nicht alles
    Ashley I Bush
    Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Neuron 65:143-4. 2010
    ..in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular Mg2+ elevation mimics sustained synaptic Zn2+ concentrations by increasing hippocampal NR2B expression and bouton density...
  2. ncbi Drug development based on the metals hypothesis of Alzheimer's disease
    Ashley I Bush
    The Mental Health Research Institute of Victoria, Parkville, Vic, Australia
    J Alzheimers Dis 15:223-40. 2008
    ..It has performed very satisfactorily in toxicology and Phase I clinical trials and is advancing as a disease-modifying candidate drug for Alzheimer's disease...
  3. doi Decline in cognitive function over 18 months in healthy older adults with high amyloid-β
    Kathryn A Ellis
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 34:861-71. 2013
    ....
  4. doi Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Neuron 59:43-55. 2008
    ..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...
  5. doi Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease
    Alan Rembach
    The Mental Health Research Institute, The University of Melbourne, Vic, Australia
    J Alzheimers Dis 34:171-82. 2013
    ..The aim of this study was to determine the diagnostic value of serum copper, CP, and non-CP copper levels in a large cohort of AD subjects...
  6. pmc Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute, Parkville, Victoria, Australia
    PLoS ONE 6:e17669. 2011
    ..In Alzheimer's disease therefore, PBT2 may restore the uptake of physiological metal ions trapped within extracellular β-amyloid aggregates that then induce biochemical and anatomical changes to improve cognitive function...
  7. doi BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neurobiol Aging 34:2457-64. 2013
    ..High Aβ levels coupled with Met carriage may be useful prognostic markers of accelerated cognitive decline and hippocampal degeneration in individuals in the preclinical stage of AD. ..
  8. doi Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats
    Kwok Ho Christopher Choy
    Mental Health Research Institute, Parkville, Victoria, Australia
    Eur J Pharmacol 649:224-8. 2010
    ..These effects appear to be dose-dependent and region-specific. These results may be relevant to the understanding and management of the cognitive symptoms of schizophrenia and bipolar disorder...
  9. doi Cognitive consequences of high Aβ amyloid in mild cognitive impairment and healthy older adults: implications for early detection of Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neuropsychology 27:322-32. 2013
    ..We aimed to determine the extent to which high Aβ amyloid influenced cognitive function in healthy older adults and adults with MCI...
  10. pmc Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease
    Ya Hui Hung
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    J Biol Chem 284:21899-907. 2009
    ..copper complexes are more likely to form. This explains the paradoxical hypermetallation of Abeta with copper under tissue copper deficiency conditions in AD...
  11. doi Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice
    Christa J Maynard
    Department of Pathology, The University of Melbourne, Melbourne, Vic, 3010, Australia
    Cell Mol Neurobiol 29:757-67. 2009
    ....
  12. doi The role of metallobiology and amyloid-β peptides in Alzheimer's disease
    Blaine R Roberts
    Mental Health Research Institute, The University of Melbourne, 155 Oak Street, Parkville, Vic, Australia
    J Neurochem 120:149-66. 2012
    ....
  13. pmc Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity
    Mark A Greenough
    Mental Health Research Institute, Parkville, Victoria 3052, Australia
    J Biol Chem 286:9776-86. 2011
    ..These data indicate that presenilins are important for cellular copper and zinc turnover, influencing SOD1 activity, and having the potential to indirectly impact β-amyloid aggregation through metal ion clearance...
  14. pmc Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's disease: a preliminary study
    Yen Ying Lim
    Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 9:e86498. 2014
    ..We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance, hippocampal volume, and Aβ accumulation in adults with amnestic mild cognitive impairment (aMCI) and high Aβ...
  15. doi Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease
    Scott Ayton
    Oxidation Biology Laboratory, Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia
    Ann Neurol 73:554-9. 2013
    ..These findings show, in principle, that intravenous ceruloplasmin may have therapeutic potential in PD...
  16. doi Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-β: prodromal Alzheimer's disease?
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 33:1167-76. 2013
    ....
  17. pmc Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
    James A Duce
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3052, Australia
    Cell 142:857-67. 2010
    ..Abnormal exchange of cortical zinc may link amyloid pathology with neuronal iron accumulation in AD...
  18. doi N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder
    Olivia M Dean
    The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Neurosci Lett 499:149-53. 2011
    ..While NAC was shown to be beneficial in this model, the lack of additional glutathione depletion by amphetamine in combination with CHX does not support a summative interaction between oxidative stress and altered dopamine transmission...
  19. pmc Metals and amyloid-beta in Alzheimer's disease
    Christa J Maynard
    Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Exp Pathol 86:147-59. 2005
    ..Clinical trials are currently studying agents that can remedy abnormal Abeta-metal interactions...
  20. doi Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein
    Scott Ayton
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 35:3591-7. 2015
    ..Conversely, APP-overexpressing mice are protected in the MPTP PD model. NO suppresses APP translation in mouse MPTP models, explaining how elevated NO causes iron-dependent neurodegeneration in PD. ..
  21. doi Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
    Peng Lei
    Mental Health Research Institute, The University of Melbourne, Victoria, Australia
    Nat Med 18:291-5. 2012
    ..These data suggest that the loss of soluble tau could contribute to toxic neuronal iron accumulation in Alzheimer's disease, Parkinson's disease and tauopathies, and that it can be rescued pharmacologically...
  22. ncbi Metals and Alzheimer's disease
    Paul A Adlard
    The Oxidation Disorders Laboratory, The Mental Health Research Institute, Parkville, Victoria, 3052, Australia
    J Alzheimers Dis 10:145-63. 2006
    ..This offers a broad biochemical front for novel therapeutic interventions...
  23. doi Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics
    James A Duce
    The Mental Health Research Institute, Parkville, Victoria 3052, Australia
    Prog Neurobiol 92:1-18. 2010
    ..Accordingly, assisting the balance of metal ions back to homeostatic levels has been proposed as a disease-modifying therapeutic strategy for Alzheimer's disease as well as other neurodegenerative diseases...
  24. ncbi Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease
    Carlos Opazo
    Oxidation Disorders Laboratory, Mental Health Research Institute of Victoria, and Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    Aging Cell 5:69-79. 2006
    ..These data support metallated Abeta species as the neuropharmacological target of CQ and indicate that this drug class may have potential as in vivo imaging agents for Alzheimer neuropathology...
  25. pmc Rubidium and potassium levels are altered in Alzheimer's disease brain and blood but not in cerebrospinal fluid
    Blaine R Roberts
    The Florey Institute of Neuroscience, The University of Melbourne, Parkville, Vic, Australia
    Acta Neuropathol Commun 4:119. 2016
    ..These findings may be the basis for potential diagnostic imaging studies using radioactive potassium and rubidium tracers...
  26. doi An increased neutrophil-lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation
    Alan Rembach
    The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria 3052, Australia
    J Neuroimmunol 273:65-71. 2014
    ..In conclusion, the NLR may reflect AD-related inflammatory processes in the periphery, but age and sex are dominant covariates which need to be controlled for in population-based screening...
  27. ncbi Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
    Craig W Ritchie
    Departments of Pathology, The University of Melbourne, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Arch Neurol 60:1685-91. 2003
    ..Alzheimer disease (AD) may be caused by the toxic accumulation of beta-amyloid (Abeta)...
  28. doi Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse
    Jessica L Billings
    The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia
    ACS Chem Neurosci 7:360-6. 2016
    ..These data suggest that Fe exposure during a critical developmental window, combined with the overexpression mutant α-synuclein, presents a disease phenotype resistant to intervention using clioquinol later in life. ..
  29. doi High order W02-reactive stable oligomers of amyloid-β are produced in vivo and in vitro via dialysis and filtration of synthetic amyloid-β monomer
    Elysia Robb
    The Florey Institute of Neuroscience and Mental Health, Division of Mental Health, Parkville, Vic, Australia
    J Alzheimers Dis 44:69-78. 2015
    ..These data suggest that the experimental detection of higher order oligomers in tissues derived from Alzheimer's disease brains or from animal models of disease could, in some cases, be a product the method of analysis. ..
  30. doi Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry
    Dominic J Hare
    The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, Victoria 3052, Australia
    Metallomics 5:1656-62. 2013
    ..Separation and detection by SEC-ICP-MS allows appraisal of these metalloproteins in their native state, and online quantification was achieved using this relatively simple external calibration process. ..
  31. doi Decreased serum zinc is an effect of ageing and not Alzheimer's disease
    Alan Rembach
    The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    Metallomics 6:1216-9. 2014
    ..4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed. ..
  32. pmc Pharmacotherapeutic targets in Alzheimer's disease
    Yif at Biran
    The Oxidation Biology Laboratory, The Mental Health Research Institute, Parkville, Victoria, Australia
    J Cell Mol Med 13:61-86. 2009
    ..We will review the way these pharmacological strategies target the biochemical and clinical features of the disease and the investigational drugs for each category...
  33. doi Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute, Parkville, Victoria 3052, Australia
    J Neurosci 30:1631-6. 2010
    ....
  34. doi Interaction of glutathione depletion and psychotropic drug treatment in prepulse inhibition in rats and mice
    Olivia Dean
    Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Pharmacol Biochem Behav 97:293-300. 2010
    ..The significance of these results for schizophrenia is discussed...
  35. doi A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease
    Victoria M Perreau
    Neuroproteomics and Neurogenomics Platform, National Neurosciences Facility, The University of Melbourne, Parkville, Vic, Australia
    Proteomics 10:2377-95. 2010
    ..Gene ontology and network analysis were used to identify potentially novel functional relationships among interacting proteins...
  36. doi Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice
    David I Finkelstein
    The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia
    ACS Chem Neurosci 7:119-29. 2016
    ..In conclusion, our data suggests that CQ is capable of mitigating the pathological metal/α-syn interactions, suggesting that the modulation of metal ions warrants further study as a therapeutic approach for the synucleinopathies. ..
  37. doi PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses
    Noel G Faux
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 20:509-16. 2010
    ..72, p=0.056). There were no correlations between changes in CSF amyloid-beta or tau species and cognitive changes. These findings further encourage larger-scale testing of PBT2 for AD...
  38. doi Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms
    Michael A Cater
    Oxidation Biology Laboratory, Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Biochem J 412:141-52. 2008
    ..Overall our results suggest that correcting brain copper imbalance represents a relevant therapeutic target for Alzheimer's disease...
  39. doi The effect of dopamine on MPTP-induced rotarod disability
    Scott Ayton
    Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, University of Melbourne, Parkville, Australia
    Neurosci Lett 543:105-9. 2013
    ..Paradoxically, rotarod disability coincided with gradual striatal dopamine restoration. l-Dopa supplementation exacerbated rotarod disability, whereas dopamine antagonism restored performance...
  40. doi The metal theory of Alzheimer's disease
    Ashley I Bush
    Oxidation Biology Laboratory, Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 33:S277-81. 2013
    ..Therefore, amyloid and tau pathology arise in a milieu of constitutively high metal flux, and the major components of AD pathology may contribute to the disease by failing in their metal transport roles...
  41. doi Rapid generation of dityrosine cross-linked Aβ oligomers via Cu-redox cycling
    Adam P Gunn
    Mental Health Research Institute, University of Melbourne, Parkville, Vic, Australia
    Methods Mol Biol 849:3-10. 2012
    ..Here we report a simple and reproducible method for the production of radically derived dityrosine cross-linked oligomers of Aβ, through reaction with copper and ascorbic acid...
  42. doi Metals in Alzheimer's and Parkinson's diseases
    Kevin J Barnham
    Bio21 Molecular Science and Biotechnology Institute, Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Curr Opin Chem Biol 12:222-8. 2008
    ..These small molecules show promise of being disease-modifying...
  43. doi The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial
    Michael Berk
    Department of Psychiatry, The University of Melbourne, Parkville, Australia
    J Affect Disord 135:389-94. 2011
    ..Given the failure of almost all modern trials of antidepressants in bipolar disorder to demonstrate efficacy, and the limited efficacy of mood stabilisers in the depressive phase of the disorder, this is a major unmet need...
  44. pmc Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease
    Kevin J Barnham
    Department of Pathology, University of Melbourne, Parkville, Victoria, 3010, Australia
    Proc Natl Acad Sci U S A 105:6813-8. 2008
    ..The potent effect of the L-PtCl(2) complexes identifies this class of compounds as therapeutic agents for AD...
  45. doi Tau protein: relevance to Parkinson's disease
    Peng Lei
    Oxidation Biology Laboratory, Mental Health Research Institute, Parkville, Victoria, Australia
    Int J Biochem Cell Biol 42:1775-8. 2010
    ..Toxic interactions with alpha synuclein may lead to hyperphosphorylation of tau and eventually to the deposition of both proteins in the disease...
  46. pmc The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42
    Gawain McColl
    Mental Health Research Institute, Parkville, Victoria 3052, Australia
    J Biol Chem 284:22697-702. 2009
    ..Although unexpected, the C. elegans model of A beta expression can now be co-opted to study the proteotoxic effects and processing of A beta(3-42)...
  47. doi Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing
    Dominic J Hare
    Elemental Bio imaging Facility, University of Technology Sydney, Broadway, New South Wales, Australia and The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    Metallomics 8:628-32. 2016
    ..However, prospective studies might reveal whether the burden of either metal modifies disease outcomes. ..
  48. doi Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects
    Linh Q Lam
    Oxidation Biology Unit, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
    ACS Chem Neurosci . 2017
    ..We confirm that in human biological samples, ceruloplasmin activity in serum is decreased in Alzheimer's disease, but in CSF a reduction of activity in Alzheimer's disease originates from the polyanion component...
  49. doi Metal chaperones prevent zinc-mediated cognitive decline
    Paul A Adlard
    The Florey Institute for Neuroscience and Mental Health and the University of Melbourne, Parkville, Victoria 3052, Australia Electronic address
    Neurobiol Dis 81:196-202. 2015
    ....
  50. doi A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe(2+) under physiologically relevant conditions
    Bruce X Wong
    Oxidation Biology Unit, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    Biochim Biophys Acta 1840:3299-310. 2014
    ..This process may be impaired in disease, and requires more accurate analytical assays to interrogate enzymatic- and auto-oxidation within a physiologically relevant environment...
  51. doi Plasma amyloid-β levels are significantly associated with a transition toward Alzheimer's disease as measured by cognitive decline and change in neocortical amyloid burden
    Alan Rembach
    The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Vic, Australia
    J Alzheimers Dis 40:95-104. 2014
    ..We evaluated the utility of longitudinal measures of plasma amyloid-β (Aβ) as a means to identify pre-symptomatic cognitive decline in Alzheimer's disease (AD) when coupled to neuroimaging and neuropsychological parameters...
  52. doi Rapid decline in episodic memory in healthy older adults with high amyloid-β
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 33:675-9. 2013
    ..High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults...
  53. doi Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study
    Noel G Faux
    The Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 27:909-22. 2011
    ..These findings underscore the association of plasma homocysteine with cognitive deterioration, although not unique to AD, and identified an unexpected abnormality of red cell folate...
  54. ncbi Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR
    Shenggen Yao
    The Walter and Eliza Hall Institute of Medical Research, and The Cooperative Research Center for Cellular Growth Factors, 1G Royal Parade, Parkville, VIC 3050, Australia
    J Pept Sci 10:210-7. 2004
    ..From the self-association constant of BC, Ka, the fraction of dimeric BC in the complex was obtained and the dissociation constant, Kd, of BC bound to A beta40 peptide was then determined to be approximately 1 mM...
  55. doi beta-Amyloid as a molecular therapeutic target in Alzheimer's disease
    Paul A Adlard
    The Oxidation Disorders Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Drugs Today (Barc) 45:293-304. 2009
    ..It will become clear that beta-amyloid represents a potent molecular target for pharmacological manipulation to perhaps prevent the onset and progression of Alzheimer's disease...
  56. ncbi Neurodegenerative diseases and oxidative stress
    Kevin J Barnham
    Department of Pathology, The University of Melbourne, The Mental Health Research Institute of Victoria, Victoria 3010, Australia
    Nat Rev Drug Discov 3:205-14. 2004
    ..However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies...
  57. ncbi Twenty years of metallo-neurobiology: where to now?
    Ashley I Bush
    Oxidation Disorders Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Eur Biophys J 37:241-5. 2008
    ..This understanding is needed if we are to move beyond the promising, but semi-empirical, approaches to therapies of these diseases based on metal attenuation...
  58. ncbi Metal complexing agents as therapies for Alzheimer's disease
    Ashley I Bush
    Oxidation Disorders Research Unit, Mental Health Research Institute of Victoria, University of Melbourne, 155 Oak Street, Parkville VIC 3052, Australia
    Neurobiol Aging 23:1031-8. 2002
    ..On the basis of these results, CQ is being tested in clinical trials...
  59. doi Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice
    Olivia Dean
    Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Behav Brain Res 198:258-62. 2009
    ..In conclusion, GSH depletion induces cognitive impairment, which may be relevant to the role of GSH in psychiatric illnesses...
  60. pmc Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status
    Ya Hui Hung
    Oxidation Biology Unit, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010, Australia
    Neurotherapeutics 13:614-22. 2016
    ..Our findings indicate that pathogenic NPC1 allele carriers, who represent about 0.66 % of humans, could be vulnerable to motor and anxiety disorders. ..
  61. doi High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans
    Dominic J Hare
    Elemental Bio imaging Facility, University of Technology Sydney, Broadway, New South Wales 2007, Australia and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia
    Metallomics 8:156-60. 2016
    ..This application of distinct yet complementary chemical imaging techniques provided unique insight into essential and trace elements at the subcellular level. ..
  62. doi Traumatic brain injury induces elevation of Co in the human brain
    Blaine R Roberts
    The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    Metallomics 7:66-70. 2015
    ..The elevated Co has important implications for positron emission tomography neuroimaging. This is the first demonstration of the accumulation of Co in injured tissue explaining the previous utility of (55)Co-PET imaging in TBI...
  63. pmc β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin
    Bruce X Wong
    Oxidation Biology Unit, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 9:e114174. 2014
    ..Therefore, despite lacking ferroxidase activity, APP still supports iron export from neurons. ..
  64. doi PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease
    Robert A Cherny
    The Mental Health Research Institute, Kenneth Myer Bldg, The University of Melbourne, Royal Pde, Parkville, Vic
    J Huntingtons Dis 1:211-9. 2012
    ....
  65. pmc Therapeutics for Alzheimer's disease based on the metal hypothesis
    Ashley I Bush
    The Mental Health Research Institute, Parkville, Victoria, Australia
    Neurotherapeutics 5:421-32. 2008
    ..Small molecules targeting Abeta-metal interactions (e.g., PBT2) are currently advancing through clinical trials and show increasing promise as disease-modifying agents for Alzheimer's disease based on the "metal hypothesis."..
  66. pmc Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese
    Gawain McColl
    Mental Health Research Institute, University of Melbourne, Parkville, Australia
    PLoS ONE 7:e32685. 2012
    ..We provide the first quantitative subcellular visualization of endogenous Mn concentrations (spanning two orders of magnitude) associated with individual cells of the nematode, Caenorhabditis elegans...
  67. doi Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
    Felicity Ng
    Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, Vic, Australia
    Int J Neuropsychopharmacol 11:851-76. 2008
    ..These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions...
  68. doi N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial
    Michael Berk
    The Mental Health Research Institute of Victoria, Victoria, Australia
    Biol Psychiatry 64:468-75. 2008
    ..We hypothesized that treatment with N-acetyl cysteine (NAC), a safe, orally bioavailable precursor of glutathione, may improve the depressive component of bipolar disorder...
  69. doi Copper in the brain and Alzheimer's disease
    Ya Hui Hung
    The Mental Health Research Institute, Parkville, Vic, Australia
    J Biol Inorg Chem 15:61-76. 2010
    ..Therapeutic strategies targeting interactions between Abeta, tau and metals to restore copper and metal homeostasis are discussed...
  70. pmc A novel approach to rapidly prevent age-related cognitive decline
    Paul A Adlard
    The Florey Institute of Neuroscience and Mental Health, Kenneth Myer Building, At Genetics Lane on Royal Parade, The University of Melbourne, Melbourne, Vic, 3010, Australia
    Aging Cell 13:351-9. 2014
    ..These data demonstrate that metal chaperones are a novel approach to the treatment of age-related cognitive decline...
  71. doi Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from three cohorts
    Eileen M Moore
    Department of Psychiatry, The University of Melbourne, Parkville, Vic, Australia Barwon Health, Geelong, Vic, Australia
    J Alzheimers Dis 39:661-8. 2014
    ..Given the prevalence of low vitamin B12 levels among the elderly, and the global deployment of food fortification programs, investigation of the associations between cognitive impairment, vitamin B12, and folate are needed...
  72. pmc Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues
    Hongyun Li
    Illawarra Health and Medical Research Institute, School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Clin Sci (Lond) 122:409-19. 2012
    ....
  73. ncbi Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid
    Cyril C Curtain
    Department of Pathology, University of Melbourne, Victoria 3052, Australia
    J Biol Chem 278:2977-82. 2003
    ..Peptides that did not insert into the membrane formed beta-sheet structures on the surface of the lipid...
  74. pmc GSK-3 in Neurodegenerative Diseases
    Peng Lei
    Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia
    Int J Alzheimers Dis 2011:189246. 2011
    ..Thus, understanding the role of GSK-3 in neurodegenerative diseases will enhance our understanding of the basic mechanisms underlying the pathogenesis of these disorders and also facilitate the identification of new therapeutic avenues...
  75. pmc Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans
    Gawain McColl
    The Mental Health Research Institute, Parkville, Victoria, Australia
    Cell Metab 12:260-72. 2010
    ..We propose that lowered ILS results in metabolic and physiological changes. These DAF-16-induced changes precondition a translational response under acute stress to modulate survival...
  76. pmc Altered transition metal homeostasis in Niemann-Pick disease, type C1
    Ya Hui Hung
    Oxidation Biology Unit, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Level 4, Kenneth Myer Building, Parkville, Victoria 3010, Australia
    Metallomics 6:542-53. 2014
    ..These findings highlight the importance of NPC1 function in metal homeostasis, and indicate that metal-targeting therapy may be of value as a treatment for NP-C. ..
  77. pmc Links between copper and cholesterol in Alzheimer's disease
    Ya Hui Hung
    Oxidation Biology Laboratory, Florey Institute of Neuroscience and Mental Health Parkville, Vic, Australia Centre for Neuroscience Research, The University of Melbourne Parkville, Vic, Australia
    Front Physiol 4:111. 2013
    ..Here we present an overview of copper and cholesterol metabolism in the brain, and how their integrated failure contributes to development of AD...
  78. pmc P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid
    Ben J Gu
    Florey Neuroscience Institutes, University of Melbourne, Parkville, Victoria 3010, Australia
    J Biol Chem 287:17318-30. 2012
    ..These data suggest for the first time that metal-interacting glycoproteins present within serum are able to inhibit the scavenger activity of mononuclear phagocytes toward insoluble debris and apoptotic cells...