Alfred King Yin Lam

Summary

Affiliation: Griffith University
Country: Australia

Publications

  1. doi Quantitative analysis of the expression of TGF-alpha and EGFR in papillary thyroid carcinoma: clinicopathological relevance
    Alfred King Yin Lam
    Department of Pathology, School of Medicine, Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Pathology 43:40-7. 2011
  2. ncbi MicroRNA-34 family, mechanisms of action in cancer: a review
    Hamidreza Maroof
    Head of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia
    Curr Cancer Drug Targets 14:737-51. 2014
  3. ncbi The important roles of miR-205 in normal physiology, cancers and as a potential therapeutic target
    Haleh Vosgha
    Head of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia
    Curr Cancer Drug Targets 14:621-37. 2014
  4. ncbi BRAF inhibitor therapy for melanoma, thyroid and colorectal cancers: development of resistance and future prospects
    Md Atiqur Rahman
    Head of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia
    Curr Cancer Drug Targets 14:128-43. 2014
  5. ncbi Metachronous carcinomas in colorectum and its clinicopathological significance
    Alfred King Yin Lam
    Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Qld 4222, Australia
    Int J Colorectal Dis 27:1303-10. 2012
  6. doi Quantitative analysis of survivin in colorectal adenocarcinoma: increased expression and correlation with telomerase activity
    Alfred King Yin Lam
    Discipline of Pathology, Griffith Medical School, Medicine and Oral Health Centre, Gold Coast Campus, Gold Coast, Queensland 4222, Australia
    Hum Pathol 39:1229-33. 2008
  7. doi p16 expression in colorectal adenocarcinoma: marker of aggressiveness and morphological types
    Alfred King Yin Lam
    Division of Pathology, School of Medicine, Griffith University Gold Coast, Queensland, Australia
    Pathology 40:580-5. 2008
  8. doi Clinicopathological significance of synchronous carcinoma in colorectal cancer
    Alfred King Yin Lam
    Division of Pathology, School of Medicine, Griffith Institute of Health and Medical Research, Griffith University, Gold Coast, Australia
    Am J Surg 202:39-44. 2011
  9. doi Altered JS-2 expression in colorectal cancers and its clinical pathological relevance
    Alfred King Yin Lam
    Department of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia
    Mol Oncol 5:475-81. 2011
  10. doi hTERT expression in colorectal adenocarcinoma: correlations with p21, p53 expressions and clinicopathological features
    Alfred King Yin Lam
    Discipline of Pathology, Griffith Medical School, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Australia
    Int J Colorectal Dis 23:587-94. 2008

Collaborators

Detail Information

Publications46

  1. doi Quantitative analysis of the expression of TGF-alpha and EGFR in papillary thyroid carcinoma: clinicopathological relevance
    Alfred King Yin Lam
    Department of Pathology, School of Medicine, Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Pathology 43:40-7. 2011
    ..The aims of this study were to detect, quantify and analyse the clinicopathological correlations of the expression of these genes in a large cohort of patients with thyroid carcinoma...
  2. ncbi MicroRNA-34 family, mechanisms of action in cancer: a review
    Hamidreza Maroof
    Head of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia
    Curr Cancer Drug Targets 14:737-51. 2014
    ..Thus, microRNA-34 family members could act as prognostic markers and therapeutic targets in human cancers. ..
  3. ncbi The important roles of miR-205 in normal physiology, cancers and as a potential therapeutic target
    Haleh Vosgha
    Head of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia
    Curr Cancer Drug Targets 14:621-37. 2014
    ..To conclude, miR-205 has important clinical and pathological correlations in different cancers and may act as a diagnostic and prognostic marker as well as new molecular target for cancer therapy. ..
  4. ncbi BRAF inhibitor therapy for melanoma, thyroid and colorectal cancers: development of resistance and future prospects
    Md Atiqur Rahman
    Head of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia
    Curr Cancer Drug Targets 14:128-43. 2014
    ....
  5. ncbi Metachronous carcinomas in colorectum and its clinicopathological significance
    Alfred King Yin Lam
    Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Qld 4222, Australia
    Int J Colorectal Dis 27:1303-10. 2012
    ..The study was designed to examine the significance of colorectal metachronous carcinoma in a large cohort of patients...
  6. doi Quantitative analysis of survivin in colorectal adenocarcinoma: increased expression and correlation with telomerase activity
    Alfred King Yin Lam
    Discipline of Pathology, Griffith Medical School, Medicine and Oral Health Centre, Gold Coast Campus, Gold Coast, Queensland 4222, Australia
    Hum Pathol 39:1229-33. 2008
    ..The high prevalence of survivin expression and correlation with telomerase activity are important factors for consideration in gene targeting therapy for colorectal adenocarcinoma...
  7. doi p16 expression in colorectal adenocarcinoma: marker of aggressiveness and morphological types
    Alfred King Yin Lam
    Division of Pathology, School of Medicine, Griffith University Gold Coast, Queensland, Australia
    Pathology 40:580-5. 2008
    ..The aim of the present study was to investigate the clinicopathological roles of p16 expression in a large cohort of patients with colorectal adenocarcinoma with tight methodology and close follow-up...
  8. doi Clinicopathological significance of synchronous carcinoma in colorectal cancer
    Alfred King Yin Lam
    Division of Pathology, School of Medicine, Griffith Institute of Health and Medical Research, Griffith University, Gold Coast, Australia
    Am J Surg 202:39-44. 2011
    ..Synchronous colorectal carcinoma has seldom been studied in large series. The study was designed to examine the significance of colorectal synchronous carcinoma in a large cohort of patients...
  9. doi Altered JS-2 expression in colorectal cancers and its clinical pathological relevance
    Alfred King Yin Lam
    Department of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia
    Mol Oncol 5:475-81. 2011
    ..In addition, genetic alteration of JS-2 was found to be related to location, pathological subtypes and staging of colorectal cancer...
  10. doi hTERT expression in colorectal adenocarcinoma: correlations with p21, p53 expressions and clinicopathological features
    Alfred King Yin Lam
    Discipline of Pathology, Griffith Medical School, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Australia
    Int J Colorectal Dis 23:587-94. 2008
    ....
  11. ncbi Diffuse sclerosing variant of papillary carcinoma of the thyroid: a 35-year comparative study at a single institution
    Alfred King Yin Lam
    Discipline of Pathology, School of Medicine, Gold Coast Campus, Griffith University, PMB 50 Gold Coast Mail Centre, Queensland, 9726, Australia
    Ann Surg Oncol 13:176-81. 2006
    ..The aim of this study was to analyze the clinicopathologic features of a large cohort of patients with this disease...
  12. ncbi Papillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variants
    Alfred King Yin Lam
    Discipline of Pathology, School of Medicine, Griffith University, Gold Coast, Australia
    Endocr Pathol 16:323-30. 2005
    ..We conclude that a high prevalence of different variants of PTC with distinct clinicopathological features can be documented. Recognition of these histological variants may be important for better management of patients with PTC...
  13. ncbi Resuscitating the teaching of anatomical pathology in undergraduate medical education: Web-based innovative clinicopathological cases
    Alfred King Yin Lam
    School of Medicine, Griffith University, PMB 50 Gold Coast Mail Centre, Queensland, Australia
    Pathology 37:360-3. 2005
    ..This paper reports the development and evaluation of an innovative approach in an undergraduate medical school to supporting pathology lectures, through integrating pathology with clinical medicine...
  14. ncbi Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior
    King Yin Lam
    Discipline of Pathology, School of Medicine, Griffith University, Gold Coast, Australia
    Endocr Pathol 16:83-9. 2005
    ..The patient developed distant metastases after operation and died of the disease 18 mo after the operation. The present case is the first reported case of Warthin tumor-like variant of papillary thyroid carcinoma with anaplastic changes...
  15. doi Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity
    Alfred King Yin Lam
    Division of Pathology, School of Medicine, Griffith Medical School, Griffith University Gold Coast Campus, Gold Coast, Queensland 4222, Australia
    Hum Pathol 39:599-604. 2008
    ..These findings may be important to select patients to benefit for clinical trials of aurora kinase inhibitors...
  16. ncbi Colorectal mucinous adenocarcinoma: the clinicopathologic features and significance of p16 and p53 expression
    Alfred King-Yin Lam
    Division of Pathology, Griffith Medical School, Medicine and Oral Health Center, PMB 50 GCMC Bundall, Gold Coast, Queensland 9726, Australia
    Dis Colon Rectum 49:1275-83. 2006
    ..This study was designed to examine the clinicopathologic features and p53 and p16 expressions in colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma...
  17. ncbi Clinicopathological roles of alterations of tumor suppressor gene p16 in papillary thyroid carcinoma
    Alfred King Yin Lam
    Discipline of Pathology, School of Medicine, Griffith University, PMB 50 Gold Coast Mail Centre, Queensland, 9726, Australia
    Ann Surg Oncol 14:1772-9. 2007
    ..The aim of the present study was to investigate the clinicopathological roles of the p16 gene in papillary thyroid carcinoma (PTC)...
  18. doi The expression profiles of the galectin gene family in primary and metastatic papillary thyroid carcinoma with particular emphasis on galectin-1 and galectin-3 expression
    Ali Salajegheh
    Cancer Molecular Pathology, School of Medicine, Centre for Medicine and Oral Health, Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Exp Mol Pathol 96:212-8. 2014
    ..This study investigated the levels of galectin proteins and mRNA expression in a large cohort of patients with papillary thyroid carcinoma and matched lymph node metastases with particular emphasis on galectin-1 and galectin-3...
  19. doi Co-regulatory potential of vascular endothelial growth factor-A and vascular endothelial growth factor-C in thyroid carcinoma
    Ali Salajegheh
    Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland 4222, Australia
    Hum Pathol 44:2204-12. 2013
    ..The significant correlations between the expressions of these genes add weight to hypotheses concerning VEGF-A and -C interaction in cancer progression. ..
  20. doi The expression profiles of the galectin gene family in colorectal adenocarcinomas
    Vinod Gopalan
    Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland 4222, Australia
    Hum Pathol 53:105-13. 2016
    ..These altered expression patterns of galectin genes suggest the multifunctional role of galectin genes in the regulation of colorectal cancer development, progression, and metastasis. ..
  21. doi Interactive role of miR-126 on VEGF-A and progression of papillary and undifferentiated thyroid carcinoma
    Ali Salajegheh
    Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 42222, Australia
    Hum Pathol 51:75-85. 2016
    ..The current experiments provided specific information on the functional consequences of VEGF manipulation via microRNA on cancer. ..
  22. doi Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance
    Faeza Ebrahimi
    Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia
    Exp Cell Res 339:333-41. 2015
    ..To conclude, deregulation of miR-126 in colorectal cancer at the tissue and cellular levels as well as its correlation with various clinicopathological parameters confirm the cancer suppressive role of miR-126 in colorectal cancer. ..
  23. doi Stage dependent expression and tumor suppressive function of FAM134B (JK1) in colon cancer
    Farhadul Islam
    Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Mol Carcinog 56:238-249. 2017
    ..To conclude, expression analysis, in vitro and in vivo indicated that FAM134B acts as a cancer suppressor gene in colon cancer. © 2016 Wiley Periodicals, Inc...
  24. doi Multiple proliferation-survival signalling pathways are simultaneously active in BRAF V600E mutated thyroid carcinomas
    Md Atiqur Rahman
    Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia
    Exp Mol Pathol 99:492-7. 2015
    ..The aim of our study was to investigate whether the downstream signalling pathway of BRAF and AKT kinase signalling pathways were active in BRAF V600E mutated thyroid carcinoma cells...
  25. doi Correlation between BRAF mutation and the clinicopathological parameters in papillary thyroid carcinoma with particular reference to follicular variant
    Robert Anthony Smith
    Department of Pathology, Griffith Medical School, Gold Coast, Queensland, Gold Coast QLD 4222, Australia
    Hum Pathol 42:500-6. 2011
    ..The results of this study add further information indicating that mutations in BRAF play a role in thyroid cancer development and progression...
  26. doi Expression profile of endothelin 1 and its receptor endothelin receptor A in papillary thyroid carcinoma and their correlations with clinicopathologic characteristics
    Soussan Irani
    Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Ann Diagn Pathol 18:43-8. 2014
    ..Targeting the endothelin axis may be useful in planning angiogenesis therapy for thyroid cancer. ..
  27. doi Signet-ring cell carcinoma of colorectum--current perspectives and molecular biology
    Vinod Gopalan
    School of Medicine, Griffith Health Institute, Gold Coast, QLD, Australia
    Int J Colorectal Dis 26:127-33. 2011
    ..Colorectal signet-ring cell carcinoma (SRCC) is rare, and very little detailed information on the molecular biology of the disease is available...
  28. pmc Identification of Novel FAM134B (JK1) Mutations in Oesophageal Squamous Cell Carcinoma
    Md Hakimul Haque
    Cancer Molecular Pathology in Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia
    Sci Rep 6:29173. 2016
    ..Genetic alteration of FAM134B is a frequent event in the progression of ESCCs. These findings imply that mutation might be the major driving source of FAM134B genetic modulation in ESCCs. ..
  29. ncbi Inhibition of BRAF kinase suppresses cellular proliferation, but not enough for complete growth arrest in BRAF V600E mutated papillary and undifferentiated thyroid carcinomas
    Md Atiqur Rahman
    Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia
    Endocrine 54:129-138. 2016
    ..Thus, alternative proliferation pathways should be inhibited for therapeutic suppression of BRAF-induced proliferation in thyroid carcinomas...
  30. doi Modulatory role of miR-205 in angiogenesis and progression of thyroid cancer
    Ali Salajegheh
    Cancer Molecular PathologySchool of Medicine, Griffith Medical School, Menzies Health Institute Queensland, Gold Coast Campus, Gold Coast, Queensland 4222, AustraliaFaculty of HealthInstitute of Health and Biomedical Innovation, Genomics Research Centre, Queensland University of Technology, Brisbane, Queensland, AustraliaPathology Queensland and Gold Coast University HospitalGold Coast, Queensland, Australia
    J Mol Endocrinol 55:183-96. 2015
    ..The current experiments provided specific information on the functional consequences of VEGF manipulation via miRNA on cancer. ..
  31. doi MicroRNA-126 suppresses proliferation of undifferentiated (BRAF(V600E) and BRAF(WT)) thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K-AKT proliferation-survival signalling pathway
    Md Atiqur Rahman
    Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia
    Exp Cell Res 339:342-50. 2015
    ..The objectives of this study are to investigate the expression of miR-126 and evaluate its effect on proliferation in undifferentiated thyroid carcinoma...
  32. doi Role of microRNA-34 family in cancer with particular reference to cancer angiogenesis
    Hamidreza Maroof
    Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Exp Mol Pathol 97:298-304. 2014
    ..In addition, miR-34 is involved in the tumor angiogenesis. Understanding the mechanism of the miR-34 in cancer and tumor angiogenesis will open horizons for development of anti-cancer and anti-angiogenesis drugs. ..
  33. doi Clinicopathological relevance of BRAF mutations in human cancer
    Sahar Pakneshan
    Cancer Molecular Pathology, Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Pathology 45:346-56. 2013
    ..It is hoped that the review will enhance the direction of future research and assist in more effective use of the knowledge of BRAF mutation in clinical practice...
  34. doi Epithelial-mesenchymal transition and mesenchymal-epithelial transition are essential for the acquisition of stem cell properties in hTERT-immortalised oral epithelial cells
    Bin Qiao
    Cancer Molecular Pathology, Griffith Medical School and Griffith Health Institute, Gold Coast, Queensland 4222, Australia
    Biol Cell 104:476-89. 2012
    ..Thus, we established a project aiming to investigate the roles of EMT and MET in the acquisition of stem cell properties in immortalised oral epithelial cells...
  35. doi Modulatory roles of microRNAs in the regulation of different signalling pathways in large bowel cancer stem cells
    Afraa Mamoori
    Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia
    Biol Cell 108:51-64. 2016
    ..miRNAs were shown to regulate the function of cancer stem cells in large bowel cancer by targeting a few key signalling pathways in cells. ..
  36. doi miR-126 in human cancers: clinical roles and current perspectives
    Faeza Ebrahimi
    Cancer Molecular Pathology, Griffith Health Institute, Griffith University, Gold Coast, Australia
    Exp Mol Pathol 96:98-107. 2014
    ..Understanding these mechanisms by which miR-126 is involved with cancer pathogenesis will be useful in the development of therapeutic targets for the management of patients with cancer. ..
  37. doi A review of the profile of endothelin axis in cancer and its management
    Soussan Irani
    Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Crit Rev Oncol Hematol 89:314-21. 2014
    ....
  38. pmc Irinotecan therapy and molecular targets in colorectal cancer: a systemic review
    Jessica Weekes
    Discipline of Surgery School of Medicine and North Queensland Centre for Cancer Research Australian Institute of Tropical Medicine, James Cook University, Townsville, Queensland, Australia
    World J Gastroenterol 15:3597-602. 2009
    ..It is recommended that studies of the expression of these molecular markers in relation to chemo-responsiveness of irinotecan should be carried out for better management of patients with advanced CRC...
  39. doi Integrating gross pathology into teaching of undergraduate medical science students using human cadavers
    Vinod Gopalan
    School of Medical Science, Griffith University, Gold Coast, Australia
    Pathol Int 66:511-7. 2016
    ....
  40. doi Overexpression of microRNA-1288 in oesophageal squamous cell carcinoma
    Vinod Gopalan
    Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia
    Exp Cell Res 348:146-154. 2016
    ..This study aims to examine the expression profiles miR-1288 in oesophageal squamous cell carcinoma (ESCC). The cellular implications and target interactions of ESCC cells following miR-1288 overexpression was also examined...
  41. pmc Synchronous colorectal cancer: clinical, pathological and molecular implications
    Alfred King Yin Lam
    Alfred King Yin Lam, Sally Sze Yan Chan, Melissa Leung, Cancer Molecular Pathology, Griffith Health Institute, Griffith University, Gold Coast QLD 4222, Queensland, Australia
    World J Gastroenterol 20:6815-20. 2014
    ..A different management approach and long-term clinical follow-up are recommended for some patients with synchronous colorectal cancer. ..
  42. ncbi High prevalence of RET proto-oncogene activation (RET/PTC) in papillary thyroid carcinomas
    King Yin Lam
    Division of Pathology, School of Medicine, James Cook University, Townsville, Queensland, Australia
    Eur J Endocrinol 147:741-5. 2002
    ..The aim of this study was to investigate the frequency and types of PTC genetic rearrangements in papillary carcinoma in a population of Hong Kong Chinese...
  43. ncbi Bilateral adrenalectomy for corticotrophin-independent macronodular adrenocortical hyperplasia
    King Yin Lam
    Pathology Division, School of Medicine, James Cook University, Townsville, Australia
    Eur J Surg 168:425-7. 2002
  44. ncbi Real-time PCR quantification of human telomerase reverse transcriptase (hTERT) in colorectal cancer
    Said Saleh
    Department of Surgery School of Medicine and North Queensland Centre for Cancer Research Australian Institute of Tropical Medicine, James Cook University, Townsville, Australia
    Pathology 40:25-30. 2008
    ..The objective of this study was to evaluate the significance of hTERT mRNA expression in colorectal adenocarcinoma in North Queensland...
  45. ncbi Classical and follicular variant of papillary thyroid carcinoma: a comparative study on clinicopathologic features and long-term outcome
    Brian Hung Hin Lang
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    World J Surg 30:752-8. 2006
    ..The present study aimed at evaluating any potential difference in clinicopathologic features and long-term outcome of FVPTC as compared with CPTC...
  46. doi Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma
    Xiao Min Yu
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Ann Surg 247:483-9. 2008
    ..To evaluate the clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in papillary thyroid carcinoma (PTC)...