Dorit Samocha-Bonet

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. doi request reprint Insulin-sensitive obesity in humans - a 'favorable fat' phenotype?
    D Samocha-Bonet
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
    Trends Endocrinol Metab 23:116-24. 2012
  2. pmc L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients
    Dorit Samocha-Bonet
    Diabetes and Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst 2010, Sydney, NSW, Australia
    Nutrients 7:2101-8. 2015
  3. doi request reprint Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?
    Dorit Samocha-Bonet
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Trends Endocrinol Metab 21:83-8. 2010
  4. pmc Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans
    Dorit Samocha-Bonet
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, Australia
    PLoS ONE 7:e36320. 2012
  5. doi request reprint Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots
    Samantha Hocking
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Sydney, Australia
    Endocr Rev 34:463-500. 2013
  6. pmc Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study
    Dorit Samocha-Bonet
    Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, Australia Faculty of Medicine, UNSW The University of New South Wales, Sydney, Australia
    PLoS ONE 9:e113366. 2014
  7. pmc Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans
    Charmaine S Tam
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, Australia
    Diabetes 59:2164-70. 2010
  8. doi request reprint Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients
    Dorit Samocha-Bonet
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
    J Nutr 141:1233-8. 2011
  9. pmc Segregation of a latent high adiposity phenotype in families with a history of type 2 diabetes mellitus implicates rare obesity-susceptibility genetic variants with large effects in diabetes-related obesity
    Arthur B Jenkins
    School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia
    PLoS ONE 8:e70435. 2013
  10. doi request reprint Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans
    Katherine T Tonks
    Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Obesity (Silver Spring) 24:908-16. 2016

Collaborators

Detail Information

Publications10

  1. doi request reprint Insulin-sensitive obesity in humans - a 'favorable fat' phenotype?
    D Samocha-Bonet
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
    Trends Endocrinol Metab 23:116-24. 2012
    ..We propose that dynamic interventional studies in insulin-sensitive obese humans may increase understanding of the metabolic factors that play a role in obesity-associated insulin resistance in humans...
  2. pmc L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients
    Dorit Samocha-Bonet
    Diabetes and Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst 2010, Sydney, NSW, Australia
    Nutrients 7:2101-8. 2015
    ..Larger studies are required to further investigate the utility of similar approaches in improving insulin response in diabetes...
  3. doi request reprint Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?
    Dorit Samocha-Bonet
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Trends Endocrinol Metab 21:83-8. 2010
    ..We propose that lipotoxic intermediates and lipid peroxides in skeletal muscle interfere with insulin signaling and might cause insulin resistance in these 'at risk' individuals...
  4. pmc Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans
    Dorit Samocha-Bonet
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, Australia
    PLoS ONE 7:e36320. 2012
    ..High fat feeding induces insulin resistance and increases skeletal muscle oxidative stress in rodents, but there is controversy as to whether skeletal muscle mitochondrial biogenesis and function is altered...
  5. doi request reprint Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots
    Samantha Hocking
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Sydney, Australia
    Endocr Rev 34:463-500. 2013
    ..Further understanding of specific roles of different lipid depots may help new approaches to control obesity and its metabolic sequelae. ..
  6. pmc Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study
    Dorit Samocha-Bonet
    Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, Australia Faculty of Medicine, UNSW The University of New South Wales, Sydney, Australia
    PLoS ONE 9:e113366. 2014
    ..The aim of the study was to assess the efficacy and safety of daily glutamine supplementation with or without the dipeptidyl peptidase (DPP)-4 inhibitor sitagliptin in well-controlled type 2 diabetes patients...
  7. pmc Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans
    Charmaine S Tam
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, Australia
    Diabetes 59:2164-70. 2010
    ..The aim of this study was to assess whether overfeeding induces peripheral insulin resistance in lean and overweight humans, and, if so, whether it is associated with increased systemic and adipose tissue inflammation...
  8. doi request reprint Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients
    Dorit Samocha-Bonet
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia
    J Nutr 141:1233-8. 2011
    ..These findings suggest that glutamine may be a novel agent for stimulating GLP-1 concentration and limiting postprandial glycemia in type 2 diabetes...
  9. pmc Segregation of a latent high adiposity phenotype in families with a history of type 2 diabetes mellitus implicates rare obesity-susceptibility genetic variants with large effects in diabetes-related obesity
    Arthur B Jenkins
    School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia
    PLoS ONE 8:e70435. 2013
    ..We have estimated the extent and mode of inheritance of susceptibility to increased adiposity in FH+...
  10. doi request reprint Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans
    Katherine T Tonks
    Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Obesity (Silver Spring) 24:908-16. 2016
    ..Alterations in lipids in muscle and plasma have been documented in insulin-resistant people with obesity. Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear...