D Ross Laybutt

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. pmc Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance
    Mia C Akerfeldt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Diabetes 60:2506-14. 2011
  2. ncbi request reprint Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets
    Stacey N Walters
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia St Vincent s Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    J Mol Endocrinol 51:225-32. 2013
  3. pmc Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes
    Jeng Yie Chan
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Diabetes 62:1557-68. 2013
  4. doi request reprint Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
    Sheau Fang Ng
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
    Nature 467:963-6. 2010
  5. pmc Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling
    Jenny E Gunton
    Diabetes and Transcription Factors Group, Garvan Institute of Medical Research, Sydney, Australia
    PLoS ONE 7:e39462. 2012
  6. doi request reprint A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
    Ebru Boslem
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Biochem J 435:267-76. 2011
  7. ncbi request reprint Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis
    Anna K Busch
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney 2010, Australia
    Diabetes 54:2917-24. 2005
  8. pmc Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling
    Mia C Akerfeldt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Diabetes 57:3034-44. 2008
  9. doi request reprint Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance
    Caroline S Achard
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Endocrinology 153:2164-77. 2012
  10. ncbi request reprint Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance
    Carsten Schmitz-Peiffer
    Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Cell Metab 6:320-8. 2007

Collaborators

Detail Information

Publications12

  1. pmc Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance
    Mia C Akerfeldt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Diabetes 60:2506-14. 2011
    ..Increased expression of the helix-loop-helix protein Id1 has been found in islets of diabetic mice and in vitro models of β-cell dysfunction. Here, we investigated the role of Id1 in insulin secretion and glucose homeostasis...
  2. ncbi request reprint Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets
    Stacey N Walters
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia St Vincent s Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    J Mol Endocrinol 51:225-32. 2013
    ..Failure of the adaptive UPR may contribute to β-cell dedifferentiation and dysfunction in diabetes. ..
  3. pmc Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes
    Jeng Yie Chan
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Diabetes 62:1557-68. 2013
    ..The ability to maintain the adaptive UPR in islets may protect against the gene expression changes that underlie diabetes development in obese mice...
  4. doi request reprint Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
    Sheau Fang Ng
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
    Nature 467:963-6. 2010
    ..76-fold increase), was demonstrated. This is the first report in mammals of non-genetic, intergenerational transmission of metabolic sequelae of a HFD from father to offspring...
  5. pmc Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling
    Jenny E Gunton
    Diabetes and Transcription Factors Group, Garvan Institute of Medical Research, Sydney, Australia
    PLoS ONE 7:e39462. 2012
    ..The aim of this study was to explore the role of Gem in insulin secretion. We hypothesised that Gem may regulate insulin secretion and thus affect glucose tolerance in vivo...
  6. doi request reprint A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
    Ebru Boslem
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Biochem J 435:267-76. 2011
    ..In conclusion, alterations in sphingolipid, rather than phospholipid, metabolism are more likely to be implicated in the defective protein trafficking and enhanced ER stress and apoptosis of lipotoxic β-cells...
  7. ncbi request reprint Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis
    Anna K Busch
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney 2010, Australia
    Diabetes 54:2917-24. 2005
    ..Our results suggest that desaturation per se is more important in protecting beta-cells from the cytotoxic effects of palmitate than is the nature of neutral lipid storage pool thus generated...
  8. pmc Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling
    Mia C Akerfeldt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Diabetes 57:3034-44. 2008
    ..We tested whether ER stress was necessary for cytokine-induced beta-cell death and also whether ER stress gene activation was present in beta-cells of the NOD mouse model of type 1 diabetes...
  9. doi request reprint Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance
    Caroline S Achard
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Endocrinology 153:2164-77. 2012
    ..However, in the absence of chronic adaptation, severe ER stress induced by high-level palmitate exposure induces deleterious UPR signaling that contributes to insulin resistance and metabolic dysregulation...
  10. ncbi request reprint Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance
    Carsten Schmitz-Peiffer
    Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Cell Metab 6:320-8. 2007
    ....
  11. ncbi request reprint Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes
    Cecilie Kjørholt
    Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney 2010, Australia
    Diabetes 54:2755-63. 2005
    ..These studies demonstrate that hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in db/db mice...
  12. pmc Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets
    Kim Cheng
    Diabetes and Transcription Factors Group, Garvan Institute of Medical Research GIMR, Sydney, New South Wales, Australia
    J Clin Invest 120:2171-83. 2010
    ..Taken together, these findings suggest an important role for HIF-1alpha in beta cell reserve and regulation of ARNT expression and demonstrate that HIF-1alpha is a potential therapeutic target for the beta cell dysfunction of T2D...