Susan Henshall

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Tissue microarrays
    Susan Henshall
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Mammary Gland Biol Neoplasia 8:347-58. 2003
  2. ncbi request reprint Zinc-alpha2-glycoprotein expression as a predictor of metastatic prostate cancer following radical prostatectomy
    Susan M Henshall
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW 2010, Australia
    J Natl Cancer Inst 98:1420-4. 2006
  3. ncbi request reprint Validation study of the accuracy of a postoperative nomogram for recurrence after radical prostatectomy for localized prostate cancer
    Markus Graefen
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:951-6. 2002
  4. ncbi request reprint Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression
    Lisa G Horvath
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, NSW, Australia
    Prostate 59:234-42. 2004
  5. ncbi request reprint Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer
    Viola A Heinzelmann-Schwarz
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia
    Clin Cancer Res 10:4427-36. 2004
  6. ncbi request reprint Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer
    Anish Bali
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales
    Clin Cancer Res 10:5168-77. 2004
  7. ncbi request reprint Pancreatic intraepithelial neoplasia in association with intraductal papillary mucinous neoplasms of the pancreas: implications for disease progression and recurrence
    Andrew V Biankin
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Am J Surg Pathol 28:1184-92. 2004
  8. ncbi request reprint Lower levels of nuclear beta-catenin predict for a poorer prognosis in localized prostate cancer
    Lisa G Horvath
    Sydney Cancer Centre, Camperdown, New South Wales, Australia
    Int J Cancer 113:415-22. 2005
  9. ncbi request reprint Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia
    Davendra Segara
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Clin Cancer Res 11:3587-96. 2005
  10. ncbi request reprint Aberrant neuropeptide Y and macrophage inhibitory cytokine-1 expression are early events in prostate cancer development and are associated with poor prognosis
    Krishan K Rasiah
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital Darlinghurst, Sydney, New South Wales, Australia
    Cancer Epidemiol Biomarkers Prev 15:711-6. 2006

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Tissue microarrays
    Susan Henshall
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Mammary Gland Biol Neoplasia 8:347-58. 2003
    ....
  2. ncbi request reprint Zinc-alpha2-glycoprotein expression as a predictor of metastatic prostate cancer following radical prostatectomy
    Susan M Henshall
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW 2010, Australia
    J Natl Cancer Inst 98:1420-4. 2006
    ....
  3. ncbi request reprint Validation study of the accuracy of a postoperative nomogram for recurrence after radical prostatectomy for localized prostate cancer
    Markus Graefen
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:951-6. 2002
    ..We evaluated the predictive accuracy of the nomogram when applied to patients of four international institutions...
  4. ncbi request reprint Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression
    Lisa G Horvath
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, NSW, Australia
    Prostate 59:234-42. 2004
    ..This study aimed to characterize aspects of the BMP pathway in PC by assessing BMP2, Smad8, and Smad4 expression in normal, hyperplastic, and malignant prostate tissue, and to correlate findings with progression to PC...
  5. ncbi request reprint Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer
    Viola A Heinzelmann-Schwarz
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia
    Clin Cancer Res 10:4427-36. 2004
    ..The aims of this study were to integrate the results from 14 transcript profiling studies of EOC to identify novel biomarkers and to examine their expression in early and late stages of the disease...
  6. ncbi request reprint Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer
    Anish Bali
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales
    Clin Cancer Res 10:5168-77. 2004
    ..However, the prognostic significance of aberrant cell cycle gene expression in EOC remains unclear...
  7. ncbi request reprint Pancreatic intraepithelial neoplasia in association with intraductal papillary mucinous neoplasms of the pancreas: implications for disease progression and recurrence
    Andrew V Biankin
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Am J Surg Pathol 28:1184-92. 2004
    ..These data suggest that PanIN lesions found in the ducts of a pancreas with IPMN may be relevant to the development of PC either coincident with IPMN or in the remnant pancreas after curative resection of IPMN...
  8. ncbi request reprint Lower levels of nuclear beta-catenin predict for a poorer prognosis in localized prostate cancer
    Lisa G Horvath
    Sydney Cancer Centre, Camperdown, New South Wales, Australia
    Int J Cancer 113:415-22. 2005
    ..Thus, the level of nuclear beta-catenin expression may be of clinical utility as a preoperative prognostic marker in low-risk localized PC...
  9. ncbi request reprint Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia
    Davendra Segara
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Clin Cancer Res 11:3587-96. 2005
    ..Here, we used oligonucleotide microarrays to interrogate mRNA expression of pancreatic cancer tissue and normal pancreas to identify novel molecular pathways dysregulated in the development and progression of pancreatic cancer...
  10. ncbi request reprint Aberrant neuropeptide Y and macrophage inhibitory cytokine-1 expression are early events in prostate cancer development and are associated with poor prognosis
    Krishan K Rasiah
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital Darlinghurst, Sydney, New South Wales, Australia
    Cancer Epidemiol Biomarkers Prev 15:711-6. 2006
    ....
  11. ncbi request reprint Cyclin E expression and outcome in pancreatic ductal adenocarcinoma
    David A Skalicky
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    Cancer Epidemiol Biomarkers Prev 15:1941-7. 2006
    ....
  12. ncbi request reprint c-Myc overexpression and endocrine resistance in breast cancer
    Catriona M McNeil
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    J Steroid Biochem Mol Biol 102:147-55. 2006
    ....
  13. ncbi request reprint Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro
    Lisa G Horvath
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, New South Wales, Australia
    Clin Cancer Res 10:615-25. 2004
    ....
  14. doi request reprint Immunohistochemical level of unsulfated chondroitin disaccharides in the cancer stroma is an independent predictor of prostate cancer relapse
    Andrew J Sakko
    Discipline of Obstetrics and Gynaecology, Research Centre for Reproductive Health, University of Adelaide, Adelaide, SA, Australia
    Cancer Epidemiol Biomarkers Prev 17:2488-97. 2008
    ..Specific alterations to chondroitin sulfate side chains occurring during tumor development may be a crucial step for disease progression in prostate cancer...
  15. ncbi request reprint DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma
    Andrew V Biankin
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Clin Oncol 20:4531-42. 2002
    ....
  16. ncbi request reprint International validation of a preoperative nomogram for prostate cancer recurrence after radical prostatectomy
    Markus Graefen
    Department of Urology, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Oncol 20:3206-12. 2002
    ..We applied this nomogram to patients from seven different institutions spanning three continents...
  17. ncbi request reprint Molecular pathogenesis of precursor lesions of pancreatic ductal adenocarcinoma
    Andrew V Biankin
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Pathology 35:14-24. 2003
    ..Characterisation of these molecular aberrations provides scope for the development of novel diagnostic and treatment strategies that will ultimately impact on the outcome for people who develop pancreatic cancer...
  18. ncbi request reprint Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse
    Susan M Henshall
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, New South Wales 2010, Australia
    Cancer Res 63:4196-203. 2003
    ....
  19. ncbi request reprint Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer
    Susan M Henshall
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Oncogene 22:6005-12. 2003
    ..These findings are consistent with a role for ZnT4 in vesicular transport of zinc to the cell membrane and potentially in efflux of zinc in the prostate...
  20. ncbi request reprint A preoperative nomogram identifying decreased risk of positive pelvic lymph nodes in patients with prostate cancer
    Ilias Cagiannos
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Urol 170:1798-803. 2003
    ..We developed a preoperative nomogram for prediction of lymph node metastases in patients with clinically localized prostate cancer...
  21. ncbi request reprint Prognostic significance of Gleason pattern in patients with Gleason score 7 prostate carcinoma
    Kris K Rasiah
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, New South Wales, Australia
    Cancer 98:2560-5. 2003
    ..They assessed the influence on outcome of a predominant poorly differentiated Gleason pattern (primary Gleason pattern [GP] 4) and/or a coincident small focus of poorly differentiated tumor of higher grade (tertiary GP 5)...
  22. ncbi request reprint Prognostic significance of preoperative factors in localized prostate carcinoma treated with radical prostatectomy: importance of percentage of biopsies that contain tumor and the presence of biopsy perineural invasion
    David I Quinn
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Cancer 97:1884-93. 2003
    ..Predicting outcome for men with clinically localized prostate carcinoma treated with curative intent remains imprecise and further evaluation of accepted and potential predictive factors is needed...
  23. pmc Common activation of canonical Wnt signaling in pancreatic adenocarcinoma
    Marina Pasca di Magliano
    Diabetes Center, Department of Medicine, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1155. 2007
    ..Wnt inhibition blocked proliferation and induced apoptosis of cultured adenocarcinoma cells, thereby providing evidence to support the development of novel therapeutical strategies for Wnt inhibition in pancreatic adenocarcinoma...
  24. doi request reprint Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer
    Lye Lin Ho
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW 2042, Australia
    Prostate 68:1421-9. 2008
    ..This study aimed to define the pattern of MRP4/ABCC4 expression in normal and malignant prostate tissue and the relationship of MRP4/ABCC4 expression and function in response to androgen signaling...
  25. ncbi request reprint Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer
    Lisa G Horvath
    Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Australia
    Prostate 67:1081-90. 2007
    ..Here, we investigated the phenotype of sFRP4 overexpression in an androgen-dependent prostate cancer model...
  26. ncbi request reprint The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer
    Roger J Daly
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW 2010, Australia
    Oncogene 21:5175-81. 2002
    ..Gab2 therefore represents a novel link between steroid and growth factor signaling in breast cancer, and when overexpressed, may modulate the sensitivity of breast cancer cells to these important growth regulators...
  27. doi request reprint Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists
    Ying Wang
    Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, Ohio, USA
    Cancer Res 68:5628-38. 2008
    ..Combined, these studies indicate that the cyclin D1b protein is aberrantly regulated and could contribute to therapeutic failure in the context of ER-positive breast cancer...
  28. ncbi request reprint EphB4 expression and biological significance in prostate cancer
    Guangbin Xia
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA
    Cancer Res 65:4623-32. 2005
    ..These data show a role for EphB4 in prostate cancer and provide a rationale to study EphB4 for diagnostic, prognostic, and therapeutic applications...
  29. ncbi request reprint An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin
    Richard W Tothill
    Ian Potter Centre for Cancer Genomics and Predictive Medicine, Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria, Australia
    Cancer Res 65:4031-40. 2005
    ..We show that the microarray SVM classifier was capable of making high confidence predictions in 11 of 13 cases. These predictions were supported by comprehensive review of the patients' clinical histories...
  30. ncbi request reprint Molecular markers of prostate cancer outcome
    David I Quinn
    Division of Oncology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastalke Avenue, Suite 3453, Los Angeles, CA 90033, USA
    Eur J Cancer 41:858-87. 2005
    ..By integrating selected markers into prospective clinical trials, there is potential for us to provide specific targeted therapy tailored for an increasing number of patients...
  31. ncbi request reprint The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome
    Asne R Bauskin
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Australia
    Cancer Res 65:2330-6. 2005
    ..The secretion and ECM association of unprocessed proMIC-1 is likely to play a central role in modulating local bioavailability of MIC-1 which can affect patient outcome in prostate cancer and other epithelial tumors...
  32. ncbi request reprint Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer
    Daniel E H Afar
    Protein Design Labs, Inc, 34801 Campus Drive, Fremont, CA 94555, USA
    Mol Cancer Ther 3:921-32. 2004
    ..These data support the further evaluation and clinical testing of huPr1-vcMMAE as a novel therapeutic for the treatment of metastatic and hormone-resistant prostate cancer...
  33. ncbi request reprint Overexpression of E2F-1 is associated with increased disease-free survival in squamous cell carcinoma of the anterior tongue
    Rhonda A Kwong
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Clin Cancer Res 9:3705-11. 2003
    ..This study sought to determine the relationship between E2F-1 and retinoblastoma protein (pRb) expression and disease outcome in squamous cell carcinoma (SCC) of the anterior tongue...
  34. ncbi request reprint E-selectin up-regulation allows for targeted drug delivery in prostate cancer
    Vinay Bhaskar
    Protein Design Labs, Inc, 34801 Campus Drive, Fremont, CA 94555, USA
    Cancer Res 63:6387-94. 2003
    ..These findings demonstrate that an E-selectin-targeting ADC has potential as a prostate cancer therapy and validates a genomics-based paradigm for the identification of cancer-specific antigens suitable for targeted therapy...
  35. ncbi request reprint Is year of radical prostatectomy a predictor of outcome in prostate cancer?
    Ilias Cagiannos
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 171:692-6. 2004
    ..We examined whether the year in which radical prostatectomy (RP) was performed is a predictor of treatment outcome after controlling for standard prognostic factors...