John Eisman

Summary

Affiliation: Garvan Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Bone resorption and osteoporotic fractures in elderly men: the dubbo osteoporosis epidemiology study
    Christian Meier
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia
    J Bone Miner Res 20:579-87. 2005
  2. pmc Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study
    Svanhild Waterloo
    Department of Community Medicine, University of Tromsø, Tromsø, Norway
    BMC Musculoskelet Disord 13:163. 2012
  3. doi request reprint Making the first fracture the last fracture: ASBMR task force report on secondary fracture prevention
    John A Eisman
    Clinical Translation and Advanced Education, Garvan Institute of Medical Research University of New South Wales St Vincent s Hospital and School of Medicine Sydney, University of Notre Dame, Sydney, NSW, Australia
    J Bone Miner Res 27:2039-46. 2012
  4. pmc Prevalence of vertebral fractures in women and men in the population-based Tromsø Study
    Svanhild Waterloo
    Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
    BMC Musculoskelet Disord 13:3. 2012
  5. pmc Abdominal fat and hip fracture risk in the elderly: the Dubbo Osteoporosis Epidemiology Study
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, UNSW, Australia
    BMC Musculoskelet Disord 6:11. 2005
  6. pmc Bone mineral density, body mass index and cigarette smoking among Iranian women: implications for prevention
    Azam Baheiraei
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, Australia
    BMC Musculoskelet Disord 6:34. 2005
  7. pmc Bone turnover in elderly men: relationships to change in bone mineral density
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
    BMC Musculoskelet Disord 8:13. 2007
  8. pmc Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis
    Bich N H Tran
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    BMC Med Genet 9:55. 2008
  9. pmc Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)
    Claire Y Wang
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    BMC Med Genet 7:57. 2006
  10. ncbi request reprint Osteoporosis prevalence and levels of treatment in primary care: the Australian BoneCare Study
    John Eisman
    Garvan Institute of Medical Research, University of New South Wales, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Bone Miner Res 19:1969-75. 2004

Detail Information

Publications74

  1. ncbi request reprint Bone resorption and osteoporotic fractures in elderly men: the dubbo osteoporosis epidemiology study
    Christian Meier
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia
    J Bone Miner Res 20:579-87. 2005
    ..3 years, high bone resorption as assessed by S-ICTP was associated with increased risk of osteoporotic fracture, independent of BMD. Combining measurements of BMD and bone turnover may improve fracture prediction in elderly men...
  2. pmc Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study
    Svanhild Waterloo
    Department of Community Medicine, University of Tromsø, Tromsø, Norway
    BMC Musculoskelet Disord 13:163. 2012
    ..The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk...
  3. doi request reprint Making the first fracture the last fracture: ASBMR task force report on secondary fracture prevention
    John A Eisman
    Clinical Translation and Advanced Education, Garvan Institute of Medical Research University of New South Wales St Vincent s Hospital and School of Medicine Sydney, University of Notre Dame, Sydney, NSW, Australia
    J Bone Miner Res 27:2039-46. 2012
    ..2012 American Society for Bone and Mineral Research...
  4. pmc Prevalence of vertebral fractures in women and men in the population-based Tromsø Study
    Svanhild Waterloo
    Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
    BMC Musculoskelet Disord 13:3. 2012
    ..The aim of this population based study was to describe, for the first time, the age- and sex specific occurrence of osteoporotic vertebral fractures in Norway...
  5. pmc Abdominal fat and hip fracture risk in the elderly: the Dubbo Osteoporosis Epidemiology Study
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, UNSW, Australia
    BMC Musculoskelet Disord 6:11. 2005
    ..It is not known whether abdominal fat is associated with hip fracture. The present study was designed to examine the association between abdominal fat and hip fracture in women and men aged 60+ years...
  6. pmc Bone mineral density, body mass index and cigarette smoking among Iranian women: implications for prevention
    Azam Baheiraei
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, Australia
    BMC Musculoskelet Disord 6:34. 2005
    ..This study was designed to estimate the modifiable distribution and determinants of bone mineral density (BMD) among Iranian women in Australia...
  7. pmc Bone turnover in elderly men: relationships to change in bone mineral density
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
    BMC Musculoskelet Disord 8:13. 2007
    ..an individual; (ii) is there a relationship between baseline measurements of bone turnover markers and subsequent change in BMD; and (iii) is there a relationship between changes in bone turnover markers and changes in femoral neck BMD?..
  8. pmc Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis
    Bich N H Tran
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    BMC Med Genet 9:55. 2008
    ..Subsequent population-based studies of the association between the LRP5 gene and BMD have yielded conflicting results. The present study was aimed at examining the association between LRP5 gene and BMD by using meta-analysis...
  9. pmc Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)
    Claire Y Wang
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    BMC Med Genet 7:57. 2006
    ..The aim of study was to examine the inter-relationships between ADRB3 gene polymorphisms, BMI, BMD and fracture risk in elderly Caucasians...
  10. ncbi request reprint Osteoporosis prevalence and levels of treatment in primary care: the Australian BoneCare Study
    John Eisman
    Garvan Institute of Medical Research, University of New South Wales, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Bone Miner Res 19:1969-75. 2004
    ..In data from a large sample of postmenopausal women attending 927 primary care physicians, 29% of women reported one or more fractures after menopause. The great majority (72%) were not on any osteoporosis-specific therapy...
  11. ncbi request reprint Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis: 2-year results from the DIVA study
    John A Eisman
    Garvan Institute of Medical Research, St Vincent s Campus and University of New South Wales, Sydney, Australia
    J Rheumatol 35:488-97. 2008
    ..We report the effects on lumbar spine and proximal femur bone mineral density (BMD) and bone resorption markers over 2 years...
  12. doi request reprint Odanacatib in the treatment of postmenopausal women with low bone mineral density: three-year continued therapy and resolution of effect
    John A Eisman
    Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    J Bone Miner Res 26:242-51. 2011
    ..Bone-resorption markers remained suppressed, whereas bone-formation markers returned to near baseline. ODN effects were reversible: bone resorption increased transiently and BMD decreased following treatment discontinuation...
  13. ncbi request reprint Residual lifetime risk of fractures in women and men
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Bone Miner Res 22:781-8. 2007
    ..Among those with BMD T-scores < or = -2.5, the risks increased to 65% in women and 42% in men...
  14. ncbi request reprint Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis
    Paul A Baldock
    Bone and Mineral Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Biol Chem 282:19092-102. 2007
    ..Thus Y1 receptor pathways act powerfully to inhibit bone production and adiposity by nonhypothalamic pathways, with potentially direct effects on bone tissue through a single pathway with Y2 receptors...
  15. ncbi request reprint Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice
    Susan J Allison
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Biol Chem 281:23436-44. 2006
    ..The increase in bone formation after release of this tonic inhibition suggests a promising new avenue for osteoporosis treatment...
  16. ncbi request reprint Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues
    Janelle B Barry
    Bone and Mineral Research Program and Molecular Modeling Facility, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney NSW 2010, Australia
    J Biol Chem 278:8224-8. 2003
    ..Thus, SKIP/NCoA-62 interacts with VDR at a highly conserved region not previously associated with coregulator binding to regulate transactivation by a molecular mechanism distinct from that of p160 coactivators...
  17. ncbi request reprint Clinical risk indices, prediction of osteoporosis, and prevention of fractures: diagnostic consequences and costs
    Chatlert Pongchaiyakul
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
    Osteoporos Int 16:1444-50. 2005
    ..Its use in the general population can result in a high false-positive rate and incur significant cost to the community...
  18. doi request reprint Enhancement of absolute fracture risk prognosis with genetic marker: the collagen I alpha 1 gene
    Bich N H Tran
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, 2010 Sydney, NSW, Australia
    Calcif Tissue Int 85:379-88. 2009
    ..The nonograms presented here can be useful for individualizing the short- and intermediate-term prognosis of fracture risk and help identify high-risk individuals for intervention for appropriate management of osteoporosis...
  19. ncbi request reprint Identification of high-risk individuals for hip fracture: a 14-year prospective study
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, New South Wales, Australia
    J Bone Miner Res 20:1921-8. 2005
    ..The combination of these risk factors accounted for 57% and 37% of hip fractures in women and men, respectively...
  20. doi request reprint Critical interplay between neuropeptide Y and sex steroid pathways in bone and adipose tissue homeostasis
    Susan J Allison
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, New South Wales, Australia
    J Bone Miner Res 24:294-304. 2009
    ..Taken together, this interaction represents a novel mechanism for the integration of endocrine and neural signals initiated in the hypothalamus and provides further insight into the coordination of bone and energy homeostasis...
  21. ncbi request reprint Prevention and treatment of glucocorticoid-induced osteoporosis: a comparison of calcitriol, vitamin D plus calcium, and alendronate plus calcium
    Philip N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    J Bone Miner Res 18:919-24. 2003
    ..These data do not suggest any difference between simple vitamin D and calcitriol but do show that alendronate was superior to either treatment for glucocorticoid induced bone loss...
  22. pmc Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight
    Paul A Baldock
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    PLoS ONE 4:e8415. 2009
    ....
  23. ncbi request reprint Osteoporotic fracture: missed opportunity for intervention
    Leah Port
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, 2010 Sydney, NSW, Australia
    Osteoporos Int 14:780-4. 2003
    ....
  24. ncbi request reprint Transient disturbance in physeal morphology is associated with long-term effects of nitrogen-containing bisphosphonates in growing rabbits
    Elisabeth J Smith
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital and University of New South Wales, Sydney, Australia
    J Bone Miner Res 20:1731-41. 2005
    ..In 44 growing rabbits, zoledronic acid caused a transient disruption of physeal morphology, retention of cartilaginous matrix in trabeculae and cortical bone of the metaphysis, and a minor decrement in tibial bone length at maturity...
  25. ncbi request reprint Risk of subsequent fracture after low-trauma fracture in men and women
    Jacqueline R Center
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, Australia
    JAMA 297:387-94. 2007
    ..There are few published long-term data on absolute risk of subsequent fracture (refracture) following initial low-trauma fracture in women and fewer in men...
  26. ncbi request reprint Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways
    Paul A Baldock
    Bone and Mineral Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, New South Wales, Australia
    J Bone Miner Res 21:1600-7. 2006
    ..Cortical bone mass is elevated in Y2(-/-) mice through greater osteoblast activity. In contrast, leptin deficiency results in reduced bone mass. We show opposing central regulation of cortical bone...
  27. ncbi request reprint Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 92:3599-603. 2007
    ..Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time...
  28. doi request reprint Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality?
    Paul Lee
    Department of Endocrinology, St Vincent s Hospital, Sydney, NSW 2010, Australia
    Intensive Care Med 35:2028-32. 2009
    ..We present a hypothetic model demonstrating how vitamin D deficiency may be an unrecognized contributor to adverse outcome in intensive care patients...
  29. doi request reprint Incidence and risk factors for low trauma fractures in men with prostate cancer
    Henrik G Ahlborg
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Bone 43:556-60. 2008
    ..The present study sought to determine the incidence of low trauma fracture in men with prostate cancer (PC), and to characterize the association between potential risk factors and fracture risk in these men...
  30. doi request reprint Pharmacogenetics of osteoporosis and the prospect of individualized prognosis and individualized therapy
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Curr Opin Endocrinol Diabetes Obes 15:481-8. 2008
    ..Description of recent progress in genetics and pharmacogenetics of osteoporosis...
  31. doi request reprint Adequacy of vitamin D replacement in severe deficiency is dependent on body mass index
    Paul Lee
    Department of Endocrinology, St Vincent s Hospital, 384 Victoria Street, Sydney, New South Wales, Australia 2010
    Am J Med 122:1056-60. 2009
    ..Obesity is associated with hypovitaminosis D. Whether body mass index (BMI) determines the replacement dose of vitamin D to achieve sufficiency is unclear...
  32. doi request reprint Osteoporosis medication and reduced mortality risk in elderly women and men
    Jacqueline R Center
    Garvan Institute of Medical Research, and St Vincent s Hospital, Sydney, New South Wales, Australia
    J Clin Endocrinol Metab 96:1006-14. 2011
    ..Osteoporotic fractures are associated with premature mortality. Antiresorptive treatment reduces refracture but mortality reduction is unclear...
  33. ncbi request reprint Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 90:6575-9. 2005
    ..Hip fracture is partially genetically determined. The present study was designed to examine the contributions of vitamin D receptor (VDR) and collagen I alpha1 (COLIA1) genotypes to the liability to hip fracture in postmenopausal women...
  34. ncbi request reprint Vitamin D receptor B1 and exon 1d: functional and evolutionary analysis
    Edith M Gardiner
    Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    J Steroid Biochem Mol Biol 89:233-8. 2004
    ..The transactivation differences between VDRB1 and the original VDR, clarified here, provide insights into mechanisms that may contribute to functional differences and potentially distinct physiological roles for these two VDR isoforms...
  35. ncbi request reprint Bone mineral density-independent association of quantitative ultrasound measurements and fracture risk in women
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Osteoporos Int 15:942-7. 2004
    ..The combination of QUS and BMD measurements may improve the accuracy of identification of women who will sustain a fracture...
  36. ncbi request reprint Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogenesis
    Elisabeth J Smith
    Orthopaedic Research Unit, Children s Hospital at Westmead, Sydney, Australia
    J Bone Miner Res 19:1698-705. 2004
    ..In this long-term study in 32 rabbits, zoledronic acid transiently increased trabeculae by delayed temporal progression of endochondral bone remodeling but did not prevent radiographic completion of bone repair...
  37. ncbi request reprint Volumetric bone density at the femoral neck as a common measure of hip fracture risk for men and women
    Jacqueline R Center
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 89:2776-82. 2004
    ..It needs further exploration for a role in assessment of hip fracture risk across the sexes and particularly in men...
  38. ncbi request reprint Limited utility of clinical indices for the prediction of symptomatic fracture risk in postmenopausal women
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, 2010, Darlinghurst, NSW, Australia
    Osteoporos Int 15:49-55. 2004
    ..48. Clinical risk scores can be used to identify women likely to have low BMD (albeit with low specificity), but they are not a useful tool to identify women who will have a fracture...
  39. ncbi request reprint Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology Study
    Kevin P Chang
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
    J Bone Miner Res 19:532-6. 2004
    ..Approximately one-half of hip fractures occurred before 80 years in men and two-thirds before 85 years in women. The age distribution of hip fractures underlines the need for earlier intervention in osteoporosis...
  40. ncbi request reprint Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300
    Gary M Leong
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Biochem Biophys Res Commun 315:1070-6. 2004
    ..Overall these results suggest that transcriptional action of SKIP may depend on distinct functional domains and cell line-specific interactions with both corepressors and coactivators...
  41. ncbi request reprint Barriers to effective management of osteoporosis in moderate and minimal trauma fractures: a prospective study
    Dana Bliuc
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    Osteoporos Int 16:977-82. 2005
    ..This study highlights the need for further exploration of barriers to osteoporosis management...
  42. ncbi request reprint Psychometric properties of the Persian version of the osteoporosis knowledge and health belief questionnaires
    Azam Baheiraei
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    Maturitas 50:134-9. 2005
  43. ncbi request reprint Femoral neck bone loss predicts fracture risk independent of baseline BMD
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    J Bone Miner Res 20:1195-201. 2005
    ..In elderly women, greater loss of BMD at the femoral neck was associated with increased risk of fracture, independent of baseline BMD and age...
  44. ncbi request reprint Vitamin D analogue-specific recruitment of vitamin D receptor coactivators
    Laura L Issa
    Bone and Mineral Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    J Bone Miner Res 17:879-90. 2002
    ..These results suggest that selective recruitment of coactivators may contribute to gene- and tissue-specific effects of vitamin D analogues...
  45. ncbi request reprint Genetic determination of bone mineral density: evidence for a major gene
    Tuan V Nguyen
    Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 88:3614-20. 2003
    ..These findings clearly support the hypothesis that a large component of the variance in BMD is under genetic control, with strong evidence for a major gene locus influencing BMD transmission...
  46. ncbi request reprint Genetic determinants of bone mass
    P A Baldock
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Campus and University of New South Wales, Sydney, Australia
    Curr Opin Rheumatol 16:450-6. 2004
    ..This review examines recent advances in the analysis of genetic determinants of bone mass. It addresses both human and animal linkage studies as well as genetic manipulations in animals, inbred mouse models, and candidate gene analyses...
  47. ncbi request reprint Effects of continuous activation of vitamin D and Wnt response pathways on osteoblastic proliferation and differentiation
    Yan chuan Shi
    Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst 2010, Sydney, Australia
    Bone 41:87-96. 2007
    ....
  48. ncbi request reprint Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression
    Pernilla Lundberg
    Neuroscience Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, New South Wales, Australia
    J Biol Chem 282:19082-91. 2007
    ....
  49. ncbi request reprint Contribution of hip strength indices to hip fracture risk in elderly men and women
    Henrik G Ahlborg
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia, and Department of Orthopaedics, Malmo University Hospital, Sweden
    J Bone Miner Res 20:1820-7. 2005
    ..However, the contribution of each of these indices to hip fracture prediction was modest in the presence of BMD...
  50. pmc FRAP analysis of nucleocytoplasmic dynamics of the vitamin D receptor splice variant VDRB1: preferential targeting to nuclear speckles
    Kathryn L Sunn
    Bone and Mineral Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Biochem J 388:509-14. 2005
    ..The results are consistent with the existence of specialized pathways to target proteins to nuclear subdomains...
  51. doi request reprint Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women
    Dana Bliuc
    Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
    JAMA 301:513-21. 2009
    ..There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture...
  52. ncbi request reprint Anti-hip fracture efficacy of biophosphonates: a Bayesian analysis of clinical trials
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, Australia
    J Bone Miner Res 21:340-9. 2006
    ..This Bayesian meta-analysis quantitatively reviewed data from 12 randomized clinical trials with 18,667 patients and found that bisphosphonate treatment was associated with a reduced risk for hip fracture by 42%...
  53. ncbi request reprint Osteoporosis: underrated, underdiagnosed and undertreated
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Med J Aust 180:S18-22. 2004
    ..Simple measures like vitamin D and calcium supplementation and use of hip protectors can reduce hip fractures, particularly in institutionalised and housebound elderly people..
  54. ncbi request reprint Vitamin D action and regulation of bone remodeling: suppression of osteoclastogenesis by the mature osteoblast
    Paul A Baldock
    Bone Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Bone Miner Res 21:1618-26. 2006
    ..This inhibition was confined to cancellous bone. This study indicates that vitamin D-mediated osteoclastogenesis is regulated locally by OPG production in the mature osteoblast...
  55. pmc Skeletal lead release during bone resorption: effect of bisphosphonate treatment in a pilot study
    Brian Gulson
    Graduate School of the Environment, Macquarie University, Sydney, New South Wales, Australia
    Environ Health Perspect 110:1017-23. 2002
    ....
  56. ncbi request reprint Bone loss, weight loss, and weight fluctuation predict mortality risk in elderly men and women
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Bone Miner Res 22:1147-54. 2007
    ..Low baseline BMD, rate of BMD loss, weight loss, and weight fluctuation are significant predictors of all-cause mortality in elderly men and women, independent of each other and of age, incident fracture, and concomitant diseases...
  57. ncbi request reprint Exploring factors influencing osteoporosis prevention and control: a qualitative study of Iranian men and women in Australia
    Azam Baheiraei
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    Maturitas 54:127-34. 2006
    ..To explore the understanding of osteoporosis risk factors and barriers that influence osteoporosis prevention and control in order to better inform the development of culturally appropriate osteoporosis preventive strategies...
  58. ncbi request reprint Risk factors for fracture in nonosteoporotic men and women
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 92:955-62. 2007
    ..It is not known which factors are associated with fracture in nonosteoporotic elderly. The aim of this study was to assess the association between fall-related risk factors and fracture risk in men and women without osteoporosis...
  59. ncbi request reprint On the association between statin and fracture: a Bayesian consideration
    Nguyen D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Bone 40:813-20. 2007
    ..This study utilized the Bayesian approach to combine existing evidence and update the association with consideration of potential bias...
  60. doi request reprint Bone remodeling during pregnancy and post-partum assessed by metal lead levels and isotopic concentrations
    Brian Gulson
    Department of Environmental Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, Australia Commonwealth Scientific and Industrial Research Organisation CSIRO, Energy Flagship, Sydney, Australia Electronic address
    Bone 89:40-51. 2016
    ..They also indicate potentially major public health implications of the transfer of maternal Pb burden to the fetus and new born. ..
  61. doi request reprint Timing of repeat BMD measurements: development of an absolute risk-based prognostic model
    Steven A Frost
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Bone Miner Res 24:1800-7. 2009
    ..The prognostic model and approach presented in this study may help improve the individualization and management of osteoporosis...
  62. ncbi request reprint Asymptomatic vertebral deformity as a major risk factor for subsequent fractures and mortality: a long-term prospective study
    Chatlert Pongchaiyakul
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
    J Bone Miner Res 20:1349-55. 2005
    ..In elderly men and women, asymptomatic vertebral deformity was found to be associated with subsequent risk of symptomatic fractures, particularly vertebral fracture, and increased risk of mortality after a fracture...
  63. ncbi request reprint Reduction of immunosuppressant therapy requirement in heart transplantation by calcitriol
    N Kathryn Briffa
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Transplantation 75:2133-4. 2003
    ....
  64. ncbi request reprint Promoter-, cell-, and ligand-specific transactivation responses of the VDRB1 isoform
    Luis M Esteban
    Bone and Mineral Research Program, Garvan Institute of Medical Research and St Vincents Hospital, University of New South Wales, Sydney, NSW 2010, Australia
    Biochem Biophys Res Commun 334:9-15. 2005
    ..These results indicate that regulation of VDRB1 transactivation activity is dependent on cellular context, promoter, and the nature of the ligand...
  65. ncbi request reprint A meta-analysis of milk intake and fracture risk: low utility for case finding
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 16:799-804. 2005
    ..We conclude that a self-reported low intake of milk is not associated with any marked increase in fracture risk and that the use of this risk indicator is of little or no value in case-finding strategies...
  66. ncbi request reprint Contribution of lean tissue mass to the urban-rural difference in bone mineral density
    Chatlert Pongchaiyakul
    Department of Endocrinology, Khon Kaen University Medical School, Khon Kaen, Thailand
    Osteoporos Int 16:1761-8. 2005
    ..These data are thus consistent with the hypothesis that the urban-rural difference in BMD at a weight-bearing site is in part associated with the urban-rural difference in lean mass...
  67. ncbi request reprint 7: Treatment of osteoporosis: why, whom, when and how to treat. The single most important consideration is the individual's absolute risk of fracture
    Ego Seeman
    Endocrine Unit, Austin and Repatriation Medical Centre, Studley Road, Heidelberg, VIC 3084, Australia
    Med J Aust 180:298-303. 2004
    ....
  68. ncbi request reprint Genetics of bone mineral density: evidence for a major pleiotropic effect from an intercontinental study
    Gregory Livshits
    Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Bone Miner Res 19:914-23. 2004
    ..In addition to possible shared (pleiotropic) genetic and environmental effects, each of the BMD variables may also be determined by site-specific genetic factors...
  69. ncbi request reprint Alcohol intake as a risk factor for fracture
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 16:737-42. 2005
    ..We conclude that reported intake of alcohol confers a risk of some importance beyond that explained by BMD. The validation of this risk factor on an international basis permits its use in case-finding strategies...
  70. doi request reprint Multiple genetic loci for bone mineral density and fractures
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    N Engl J Med 358:2355-65. 2008
    ..Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated with bone mineral density and fracture...
  71. ncbi request reprint Predictive value of BMD for hip and other fractures
    Olof Johnell
    Department of Orthopaedics, Malmo University Hospital, Malmo, Sweden
    J Bone Miner Res 20:1185-94. 2005
    ..Low hip BMD was an important predictor of fracture risk. The prediction of hip fracture with hip BMD also depended on age and z score...
  72. ncbi request reprint Challenges in science and academic-industry interactions
    John A Eisman
    J Bone Miner Res 22:1654-5. 2007
  73. ncbi request reprint Vitamin D in Australia. Issues and recommendations
    Caryl A Nowson
    School of Health Sciences, Deakin University, Victoria
    Aust Fam Physician 33:133-8. 2004
    ..It is no longer acceptable to assume that all people in Australia receive adequate vitamin D from casual exposure to sunlight...
  74. doi request reprint Endogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology Study
    Christian Meier
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Switzerland
    Arch Intern Med 168:47-54. 2008
    ..We prospectively examined the relationship between serum levels of testosterone and estradiol and future fracture risk in community-dwelling men...