Garvan Institute of Medical Research

Summary

Organization: Garvan Institute of Medical Research
Country: Australia

Top Publications

  1. doi The hypoxia response pathway and β-cell function
    J Cantley
    Faculty of Medicine, Rayne Institute, University College London, London, UK
    Diabetes Obes Metab 12:159-67. 2010
  2. doi T cell homeostasis
    Jonathan Sprent
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Immunol Cell Biol 86:312-9. 2008
  3. pmc New insight into the mechanism by which acute physical exercise ameliorates insulin resistance
    Andrew J Hoy
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    J Physiol 586:2251-2. 2008
  4. doi Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance and neurotoxicity
    Robert Owe-Young
    University of New South Wales Centre for Immunology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    J Neurochem 105:1346-57. 2008
  5. doi T follicular helper (TFH) cells in normal and dysregulated immune responses
    Cecile King
    Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Annu Rev Immunol 26:741-66. 2008
  6. ncbi Visualizing the effects of antigen affinity on T-dependent B-cell differentiation
    Robert Brink
    Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Immunol Cell Biol 86:31-9. 2008
  7. ncbi Long-term exposure to histamine induces the expression of an embryonic-like motor pattern in an adult nervous system
    Jeremy M Sullivan
    Laboratoire de Neurobiologie des Réseaux, Université Bordeaux I and Centre Nationale de la Recherche Scientifique, Unité Mixte de Recherche 5816, Avenue des Facultes, 33405 Talence Cedex, France
    Eur J Neurosci 26:3181-92. 2007
  8. ncbi Repertoires of aggregation-resistant human antibody domains
    Daniel Christ
    Laboratory of Molecular Biology, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, UK
    Protein Eng Des Sel 20:413-6. 2007
  9. ncbi The role of spontaneous activity in development of the endbulb of Held synapse
    Sarah M McKay
    Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia
    Hear Res 230:53-63. 2007
  10. ncbi Human IgM+CD27+ B cells: memory B cells or "memory" B cells?
    Stuart G Tangye
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Immunol 179:13-9. 2007

Detail Information

Publications62

  1. doi The hypoxia response pathway and β-cell function
    J Cantley
    Faculty of Medicine, Rayne Institute, University College London, London, UK
    Diabetes Obes Metab 12:159-67. 2010
    ....
  2. doi T cell homeostasis
    Jonathan Sprent
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Immunol Cell Biol 86:312-9. 2008
    ..Here, we review how contact with exogenous stimuli, notably self MHC ligands and various gamma(c) cytokines, plays a decisive role in controlling normal T cell homeostasis...
  3. pmc New insight into the mechanism by which acute physical exercise ameliorates insulin resistance
    Andrew J Hoy
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    J Physiol 586:2251-2. 2008
  4. doi Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance and neurotoxicity
    Robert Owe-Young
    University of New South Wales Centre for Immunology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    J Neurochem 105:1346-57. 2008
    ..The results point to a mechanism whereby a systemic inflammatory signal can be transduced across an intact BBB to cause local neurotoxicity...
  5. doi T follicular helper (TFH) cells in normal and dysregulated immune responses
    Cecile King
    Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Annu Rev Immunol 26:741-66. 2008
    ..Consequently, dysregulation of T(FH) cell function, and over- or under-expression of T(FH) cell-associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies...
  6. ncbi Visualizing the effects of antigen affinity on T-dependent B-cell differentiation
    Robert Brink
    Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Immunol Cell Biol 86:31-9. 2008
    ..Recent data obtained with this system indicate that antigen-dependent variables play a critical role in regulating the differentiation of responding B cells into antibody-secreting plasma cells...
  7. ncbi Long-term exposure to histamine induces the expression of an embryonic-like motor pattern in an adult nervous system
    Jeremy M Sullivan
    Laboratoire de Neurobiologie des Réseaux, Université Bordeaux I and Centre Nationale de la Recherche Scientifique, Unité Mixte de Recherche 5816, Avenue des Facultes, 33405 Talence Cedex, France
    Eur J Neurosci 26:3181-92. 2007
    ..Furthermore, they indicate that histamine is able to induce the expression of an embryonic-like rhythm in an adult system, suggesting that long-term actions of histamine may play key roles in the development of the STNS networks...
  8. ncbi Repertoires of aggregation-resistant human antibody domains
    Daniel Christ
    Laboratory of Molecular Biology, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, UK
    Protein Eng Des Sel 20:413-6. 2007
    ....
  9. ncbi The role of spontaneous activity in development of the endbulb of Held synapse
    Sarah M McKay
    Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia
    Hear Res 230:53-63. 2007
    ..7-fold) after hearing onset while release probability remained constant (0.5). Overall, the results in deafness mice suggest that synaptic strength is altered in the absence of spontaneous auditory nerve activity...
  10. ncbi Human IgM+CD27+ B cells: memory B cells or "memory" B cells?
    Stuart G Tangye
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Immunol 179:13-9. 2007
    ..In this review we will provide alternate interpretations of the biology of IgM+CD27+ B cells and propose that they are indeed memory cells...
  11. ncbi Impaired fat oxidation after a single high-fat meal in insulin-sensitive nondiabetic individuals with a family history of type 2 diabetes
    Leonie K Heilbronn
    Diabetes and Obesity Program, Garvan Institute of Medical Research, New South Wales, Australia
    Diabetes 56:2046-53. 2007
    ..In conclusion, an impaired ability to increase fatty acid oxidation precedes the development of insulin resistance in genetically susceptible individuals. PGC1alpha and FAT/CD36 are likely candidates in mediating this response...
  12. ncbi B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling
    Fabienne Mackay
    The Autoimmunity Research Unit, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Curr Opin Immunol 19:327-36. 2007
    ..In recent years, our understanding of cell signaling and autoimmune mechanisms in this system have seen major advances, refining new possibilities for therapeutic intervention...
  13. ncbi Biochemical properties and cellular localisation of STIM proteins
    Marie A Dziadek
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Cell Calcium 42:123-32. 2007
    ..On the basis of recent functional studies a model can be proposed to explain how the biochemical properties of STIM1 contribute to its precise membrane localisation and its function in regulating SOC entry...
  14. ncbi Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects
    Leonie K Heilbronn
    Diabetes and Obesity Research Program, Garvan Institute for Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Clin Endocrinol Metab 92:1467-73. 2007
    ..Impaired mitochondrial function in skeletal muscle is implicated in the development of insulin resistance. However, potential differences in fatness and fitness may influence previous results...
  15. pmc Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response
    Alexander Swarbrick
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 105:5402-7. 2008
    ..Mice in which Id1 expression was inactivated also exhibited greatly reduced pulmonary metastatic load. These data demonstrate that established tumors remain sensitive to senescence and that Id1 may be a valuable target for therapy...
  16. ncbi Role of the autonomic nervous system and neuropeptides in the development of obesity in humans: targets for therapy?
    Jerry R Greenfield
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research and Diabetes Centre and Department of Endocrinology, St Vincent s Hospital, Sydney, Australia
    Curr Pharm Des 14:1815-20. 2008
    ....
  17. doi The diverse roles of protein kinase C in pancreatic beta-cell function
    Trevor J Biden
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Biochem Soc Trans 36:916-9. 2008
    ..Recently, the nPKC isoform, PKCepsilon, has also been implicated in the loss of insulin secretory responsiveness that underpins the development of Type 2 diabetes...
  18. doi B-cell tolerance: mechanisms and implications
    Antony Basten
    Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Curr Opin Immunol 22:566-74. 2010
    ..In particular, new information is emerging about the molecular mechanisms involved in B-cell tolerance induction and identification of B-cell selective defects that contribute to the pathogenesis of autoimmune/inflammatory diseases...
  19. ncbi Emerging roles for B lymphocytes in Type 1 diabetes
    S Lewis Cox
    Immunology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Expert Rev Clin Immunol 5:311-24. 2009
    ....
  20. doi DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs
    Kate I Patterson
    Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia
    Biochim Biophys Acta 1803:1003-12. 2010
    ..In addition, they indicate that DUSP26 may function as a tumour suppressor in particular cancers...
  21. pmc Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer
    C Elizabeth Caldon
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Cell Div 5:2. 2010
    ..This is supported by in vitro data identifying divergent regulation of the two genes, as well as potentially different roles in vivo...
  22. doi Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?
    Dorit Samocha-Bonet
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Trends Endocrinol Metab 21:83-8. 2010
    ..We propose that lipotoxic intermediates and lipid peroxides in skeletal muscle interfere with insulin signaling and might cause insulin resistance in these 'at risk' individuals...
  23. doi Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality?
    Paul Lee
    Department of Endocrinology, St Vincent s Hospital, Sydney, NSW 2010, Australia
    Intensive Care Med 35:2028-32. 2009
    ..We present a hypothetic model demonstrating how vitamin D deficiency may be an unrecognized contributor to adverse outcome in intensive care patients...
  24. doi Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel
    Ewan K A Millar
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    J Clin Oncol 27:4701-8. 2009
    ..To determine the clinical utility of intrinsic molecular phenotype after breast-conserving therapy (BCT) with lumpectomy and whole-breast irradiation with or without a cavity boost...
  25. doi Biological determinants of endocrine resistance in breast cancer
    Elizabeth A Musgrove
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Nat Rev Cancer 9:631-43. 2009
    ..The development of large-scale computational and genetic approaches offers the promise of identifying the mediators of endocrine resistance that may be exploited as potential therapeutic targets and biomarkers of response in the clinic...
  26. doi Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses
    Dominique Gatto
    Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia
    Immunity 31:259-69. 2009
    ..EBI2 therefore provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses...
  27. doi Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase
    B D Hegarty
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Acta Physiol (Oxf) 196:129-45. 2009
    ..In addition, we consider the arguments for and against the hypothesis that dysfunctional AMPK contributes to IR. Finally we review studies which assess AMPK as an appropriate target for the prevention and treatment of T2D and MS...
  28. ncbi Dual-specificity phosphatases: critical regulators with diverse cellular targets
    Kate I Patterson
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst 2010, Sydney, NSW, Australia
    Biochem J 418:475-89. 2009
    ..The present review provides an overview of the DUSP family before focusing on atypical DUSPs, emerging as a group of proteins with vastly diverse substrate specificity and function...
  29. doi Transplant recipients on the edge of the hypocalcemia abyss
    Paul Lee
    Department of Endocrinology, St Vincent s Hospital, New South Wales, Australia
    J Heart Lung Transplant 28:93-5. 2009
    ..Regular surveillance of calcium homeostasis should be incorporated into routine clinical care of transplant recipients...
  30. doi Is mitochondrial dysfunction a cause of insulin resistance?
    Nigel Turner
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Trends Endocrinol Metab 19:324-30. 2008
    ....
  31. ncbi The role of peptide YY in regulating glucose homeostasis
    Dana Boey
    Neuroscience Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Peptides 28:390-5. 2007
    ..This review aims to present an updated summary of findings over the last few decades highlighting the role of PYY in regulating insulin output and insulin sensitivity, and the potential mechanisms involved...
  32. ncbi Behavioral profiling of NPY in aggression and neuropsychiatric diseases
    Tim Karl
    Neuroscience Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Peptides 28:326-33. 2007
    ..We will combine this information with possible strategies to evaluate the different specific phenotypes in more detail...
  33. ncbi Osteoporosis prevalence and levels of treatment in primary care: the Australian BoneCare Study
    John Eisman
    Garvan Institute of Medical Research, University of New South Wales, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Bone Miner Res 19:1969-75. 2004
    ..In data from a large sample of postmenopausal women attending 927 primary care physicians, 29% of women reported one or more fractures after menopause. The great majority (72%) were not on any osteoporosis-specific therapy...
  34. ncbi Insulin resistance and obesity
    Jerry R Greenfield
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, Australia
    Clin Dermatol 22:289-95. 2004
    ....
  35. ncbi Regulation of cytokine receptor signaling by nuclear hormone receptors: a new paradigm for receptor interaction
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    DNA Cell Biol 23:463-74. 2004
    ..Better understanding of the regulatory interaction between these two classes of receptors potentially leads to new drug design and/or therapeutic strategies for treatment of cytokine-related diseases...
  36. pmc Cortactin signalling and dynamic actin networks
    Roger J Daly
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
    Biochem J 382:13-25. 2004
    ..This article reviews current knowledge regarding the role of cortactin in signalling to the actin cytoskeleton in the context of these developments...
  37. ncbi Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout mice
    Elizabeth A Musgrove
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    J Mammary Gland Biol Neoplasia 9:55-66. 2004
    ..In this review we summarize these and other data addressing the role of p27 in normal mammary epithelium and experimental models of mammary carcinogenesis...
  38. ncbi Insulin-like growth factor binding protein-3 expression is associated with growth stimulation of T47D human breast cancer cells: the role of altered epidermal growth factor signaling
    Alison J Butt
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    J Clin Endocrinol Metab 89:1950-6. 2004
    ....
  39. ncbi Reproducibility and concordance in quantitative ultrasound measurements between densitometers: a comparative study
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
    J Clin Densitom 6:337-44. 2003
    ..These data suggest that although there are systematic differences between the UBIS and Achilles+ scanners in QUS measurements, the precision of the two instruments is equivalent...
  40. ncbi Limited utility of clinical indices for the prediction of symptomatic fracture risk in postmenopausal women
    Tuan V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, 2010, Darlinghurst, NSW, Australia
    Osteoporos Int 15:49-55. 2004
    ..48. Clinical risk scores can be used to identify women likely to have low BMD (albeit with low specificity), but they are not a useful tool to identify women who will have a fracture...
  41. ncbi Physical activity reduces genetic susceptibility to increased central systolic pressure augmentation: a study of female twins
    Jerry R Greenfield
    Department of Endocrinology, St Vincent s Hospital, Sydney, Australia
    J Am Coll Cardiol 42:264-70. 2003
    ..We sought to examine associations between the augmentation index (AI) and metabolic, adiposity, and lifestyle factors, independent of genetic influences, and to determine whether gene-environment interactions modulate these relationships...
  42. ncbi Multiple indexes of lipid availability are independently related to whole body insulin action in healthy humans
    Adamandia D Kriketos
    Diabetes and Metabolism Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 88:793-8. 2003
    ..10; P = 0.03). SMT content, circulating triglycerides, and measurements of total or central adiposity were independent predictors of whole body insulin sensitivity...
  43. ncbi PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly
    Ji Ming Ye
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Am J Physiol Endocrinol Metab 284:E531-40. 2003
    ..Additionally, it can counteract fatty liver, hepatic insulin resistance, and visceral adiposity generally associated with PPARalpha activation, but without hepatomegaly...
  44. ncbi Physiological and pharmacological regulation of 20-kDa growth hormone
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Am J Physiol Endocrinol Metab 283:E836-43. 2002
    ..The 20-kDa GH level is reduced by administration of exogenous 22-kDa GH, suggesting rapid negative feedback regulation on pituitary release...
  45. pmc Molecular characterization confirms the presence of a divergent strain of canine coronavirus (UWSMN-1) in Australia
    Matthew J Naylor
    School of Science, Food and Horticulture, University of Western Sydney, Penrith South DC, New South Wales, Australia
    J Clin Microbiol 40:3518-22. 2002
    ..These data raise the possibility that this strain is the first member of a novel third subtype of CCV...
  46. ncbi Iatrogenic Cushing's syndrome with osteoporosis and secondary adrenal failure in human immunodeficiency virus-infected patients receiving inhaled corticosteroids and ritonavir-boosted protease inhibitors: six cases
    Katherine Samaras
    Department of Endocrinology, St Vincent s Hospital and St Vincent s Clinic, Darlinghurst, New South Wales, 2010, Australia
    J Clin Endocrinol Metab 90:4394-8. 2005
    ....
  47. ncbi The E211 G>A androgen receptor polymorphism is associated with a decreased risk of metastatic prostate cancer and androgenetic alopecia
    Vanessa M Hayes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW 2010, Australia
    Cancer Epidemiol Biomarkers Prev 14:993-6. 2005
    ..2). These results suggest that the AR-E211 A allele, in linkage with the functional repeat sequences, is associated with a lower risk of metastatic prostate cancer and a lower risk of alopecia...
  48. ncbi Gene symbol: MLH1. Disease: Hereditary nonpolyposis colorectal cancer
    R Otway
    John Curtain School of Medical Research, Australian National University, Canberra
    Hum Genet 116:534. 2005
  49. ncbi 5alpha-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia
    Vanessa M Hayes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Int J Cancer 120:776-80. 2007
    ..These findings raise important questions with respect to previous assumptions concerning hormonal influences on prostate cancer risk in ageing males...
  50. ncbi Limits to physical performance and metabolism across species
    Nigel Turner
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Curr Opin Clin Nutr Metab Care 9:691-6. 2006
    ..The factors that determine each type of metabolic rate are not the same; however, all levels of energy expenditure are strongly linked with body size...
  51. ncbi Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype
    Alexander Viardot
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney Darlinghurst, New South Wales 2010, Australia
    Endocrinology 148:346-53. 2007
    ..This effect of insulin in changing T cell polarization may contribute to its antiinflammatory role not only in sepsis, but also in chronic inflammation associated with obesity and type 2 diabetes...
  52. ncbi The role of the BAFF/APRIL system on T cell function
    Fabienne Mackay
    Department of Immunology and Inflammation, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Semin Immunol 18:284-9. 2006
    ..Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation...
  53. ncbi Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity
    En Ju D Lin
    Neuroscience Research Program, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    Endocrinology 147:5094-101. 2006
    ....
  54. ncbi Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein
    T Brummer
    Cancer Research Program, The Garvan Institute of Medical Research, Sydney, NSW, Australia
    Oncogene 25:6262-76. 2006
    ..Our analysis identifies important regulatory differences between B-Raf(wt) and B-Raf(V600E) and suggests that B-Raf(V600E) cannot be inhibited by strategies aimed at blocking S446 phosphorylation or Ras activation...
  55. ncbi Pharmacogenomics of osteoporosis: opportunities and challenges
    T V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
    J Musculoskelet Neuronal Interact 6:62-72. 2006
    ....
  56. ncbi Effect of postprandial insulinemia and insulin resistance on measurement of arterial stiffness (augmentation index)
    Jerry R Greenfield
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Int J Cardiol 114:50-6. 2007
    ..Whether physiological postprandial insulinemia similarly affects AIx measurements, and whether insulin resistance modifies this response, has not been studied...
  57. ncbi Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content
    Clinton R Bruce
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Am J Physiol Endocrinol Metab 291:E99-E107. 2006
    ....
  58. ncbi Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes
    Mark E Cleasby
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Diabetes 54:2702-11. 2005
    ....
  59. ncbi Gene symbol: MSH2. Disease: Hereditary nonpolyposis colorectal cancer
    R Otway
    John Curtin School of Medical Research, Australian National University, Canberra
    Hum Genet 116:539. 2005
  60. ncbi Gene symbol: MSH2. Disease: Hereditary nonpolyposis colorectal cancer
    R Otway
    John Curtin School of Medical Research, Australian National University, Canberra
    Hum Genet 116:538. 2005
  61. ncbi Gene symbol: MSH2. Disease: Hereditary nonpolyposis colorectal cancer
    R Otway
    John Curtin School of Medical Research, Australian National University, Canberra
    Hum Genet 116:536. 2005
  62. ncbi Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2
    E A Musgrove
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
    J Biol Chem 276:47675-83. 2001
    ..These data indicate that regulation of cyclin D1 is a critical element of progestin inhibition in breast cancer cells and suggest that breast cancers overexpressing cyclin D1 may respond poorly to progestin therapy...