Arduino A Mangoni

Summary

Affiliation: Flinders University
Country: Australia

Publications

  1. ncbi Homocysteine and cardiovascular disease: current evidence and future prospects
    Arduino A Mangoni
    Department of Health Care of the Elderly, Guy s, King s, and St Thomas School of Medicine, King s College, London, United Kingdom
    Am J Med 112:556-65. 2002
  2. ncbi Impact of age on QT interval and QT dispersion in healthy subjects: a regression analysis
    Arduino A Mangoni
    Department of Health Care of the Elderly, Guy s, King s, and St Thomas School of Medicine, King s College London, UK
    Age Ageing 32:326-31. 2003
  3. ncbi Effects of folic acid supplementation on inflammatory and thrombogenic markers in chronic smokers. A randomised controlled trial
    Arduino A Mangoni
    Department of Health Care of the Elderly, Guy s, King s, and St Thomas School of Medicine, King s College Hospital Dulwich, East Dulwich Grove, London SE22 8PT, UK
    Thromb Res 110:13-7. 2003
  4. pmc The implications of a growing evidence base for drug use in elderly patients. Part 3. Beta-adrenoceptor blockers in heart failure and thrombolytics in acute myocardial infarction
    A A Mangoni
    Department of Clinical Pharmacology and Centre for Neuroscience, Flinders University, Adelaide, Australia
    Br J Clin Pharmacol 61:513-20. 2006
  5. ncbi The impact of advancing age on P-glycoprotein expression and activity: current knowledge and future directions
    Arduino A Mangoni
    Expert Opin Drug Metab Toxicol 3:315-20. 2007
  6. ncbi Cardiovascular drug therapy in elderly patients: specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations
    Arduino A Mangoni
    Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, South Australia, Australia
    Drugs Aging 22:913-41. 2005
  7. doi Symmetric dimethylarginine is an independent predictor of intradialytic hypotension
    Arduino A Mangoni
    Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Adelaide, Australia
    Am J Hypertens 21:955-9. 2008
  8. pmc The implications of a growing evidence base for drug use in elderly patients Part 2. ACE inhibitors and angiotensin receptor blockers in heart failure and high cardiovascular risk patients
    A A Mangoni
    Department of Clinical Pharmacology and Centre for Neuroscience, Flinders University, Adelaide, Australia
    Br J Clin Pharmacol 61:502-12. 2006
  9. pmc The implications of a growing evidence base for drug use in elderly patients. Part 1. Statins for primary and secondary cardiovascular prevention
    A A Mangoni
    Department of Clinical Pharmacology and Centre for Neuroscience, Flinders University, Adelaide, Australia
    Br J Clin Pharmacol 61:494-501. 2006
  10. ncbi Folic acid, inflammation, and atherosclerosis: false hopes or the need for better trials?
    Arduino A Mangoni
    Department of Clinical Pharmacology and Centre for Neuroscience, School of Medicine, Flinders University, GPO Box 2100, Adelaide 5001, Australia
    Clin Chim Acta 367:11-9. 2006

Collaborators

Detail Information

Publications43

  1. ncbi Homocysteine and cardiovascular disease: current evidence and future prospects
    Arduino A Mangoni
    Department of Health Care of the Elderly, Guy s, King s, and St Thomas School of Medicine, King s College, London, United Kingdom
    Am J Med 112:556-65. 2002
    ....
  2. ncbi Impact of age on QT interval and QT dispersion in healthy subjects: a regression analysis
    Arduino A Mangoni
    Department of Health Care of the Elderly, Guy s, King s, and St Thomas School of Medicine, King s College London, UK
    Age Ageing 32:326-31. 2003
    ..We studied the effects of age, gender, body mass index, smoking status, and blood pressure on these electrocardiographic parameters...
  3. ncbi Effects of folic acid supplementation on inflammatory and thrombogenic markers in chronic smokers. A randomised controlled trial
    Arduino A Mangoni
    Department of Health Care of the Elderly, Guy s, King s, and St Thomas School of Medicine, King s College Hospital Dulwich, East Dulwich Grove, London SE22 8PT, UK
    Thromb Res 110:13-7. 2003
    ..We investigated whether lowering homocysteine by folic acid supplementation might reduce the plasma concentration of inflammatory and thrombogenic markers in chronic smokers...
  4. pmc The implications of a growing evidence base for drug use in elderly patients. Part 3. Beta-adrenoceptor blockers in heart failure and thrombolytics in acute myocardial infarction
    A A Mangoni
    Department of Clinical Pharmacology and Centre for Neuroscience, Flinders University, Adelaide, Australia
    Br J Clin Pharmacol 61:513-20. 2006
    ..This review focuses on these trials and the age-related efficacy and safety of these drugs...
  5. ncbi The impact of advancing age on P-glycoprotein expression and activity: current knowledge and future directions
    Arduino A Mangoni
    Expert Opin Drug Metab Toxicol 3:315-20. 2007
    ..This review discusses the current knowledge about the effects of advancing age on P-glycoprotein expression and activity. A critical appraisal of the published literature and an overview on future research directions are also provided...
  6. ncbi Cardiovascular drug therapy in elderly patients: specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations
    Arduino A Mangoni
    Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, South Australia, Australia
    Drugs Aging 22:913-41. 2005
    ..In particular, there is very little information on patients >80 years of age, thus raising important concerns about the correct use of these drugs in this constantly growing population...
  7. doi Symmetric dimethylarginine is an independent predictor of intradialytic hypotension
    Arduino A Mangoni
    Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Adelaide, Australia
    Am J Hypertens 21:955-9. 2008
    ..We sought to determine whether elevated concentrations of these NO inhibitors pre-HD and/or their acute decrease during HD might mediate intradialytic hypotension (IDH)...
  8. pmc The implications of a growing evidence base for drug use in elderly patients Part 2. ACE inhibitors and angiotensin receptor blockers in heart failure and high cardiovascular risk patients
    A A Mangoni
    Department of Clinical Pharmacology and Centre for Neuroscience, Flinders University, Adelaide, Australia
    Br J Clin Pharmacol 61:502-12. 2006
    ..This review focuses on the applicability of the results of the main trials with ACE inhibitors and ARBs to the elderly population...
  9. pmc The implications of a growing evidence base for drug use in elderly patients. Part 1. Statins for primary and secondary cardiovascular prevention
    A A Mangoni
    Department of Clinical Pharmacology and Centre for Neuroscience, Flinders University, Adelaide, Australia
    Br J Clin Pharmacol 61:494-501. 2006
    ..e. statins, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-adrenoceptor blockers, and thrombolytic agents) and bone health (i.e. vitamin D and bisphosphonates)...
  10. ncbi Folic acid, inflammation, and atherosclerosis: false hopes or the need for better trials?
    Arduino A Mangoni
    Department of Clinical Pharmacology and Centre for Neuroscience, School of Medicine, Flinders University, GPO Box 2100, Adelaide 5001, Australia
    Clin Chim Acta 367:11-9. 2006
    ....
  11. pmc Folic acid: a marker of endothelial function in type 2 diabetes?
    Arduino A Mangoni
    Department of Clinical Pharmacology, Centre for Neuroscience, School of Medicine, Flinders University, Adelaide, SA, Australia
    Vasc Health Risk Manag 1:79-83. 2005
    ..Therefore, folic acid might represent a novel "biomarker" of endothelial function. We sought to determine whether plasma levels of folic acid determine endothelial-dependent vasodilation in patients with type 2 diabetes...
  12. ncbi Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes
    Arduino A Mangoni
    Department of Clinical Pharmacology, Centre for Neuroscience, Flinders University, School of Medicine, Adelaide, Australia
    Am J Hypertens 18:220-6. 2005
    ..We sought to determine whether oral folic acid supplementation, by lowering homocysteine levels, enhanced endothelial function and reduced arterial stiffness in type 2 diabetes...
  13. ncbi The emerging role of symmetric dimethylarginine in vascular disease
    Arduino A Mangoni
    Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide 5001, Australia
    Adv Clin Chem 48:73-94. 2009
    ..The second part describes the results of recent studies highlighting the important role of SDMA in modulating vascular homeostasis and vascular damage. Suggestions for future research directions on SDMA are also discussed...
  14. doi Use of non-steroidal anti-inflammatory drugs and risk of ischemic and hemorrhagic stroke in the Australian veteran community
    Arduino A Mangoni
    Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, Australia
    Pharmacoepidemiol Drug Saf 19:490-8. 2010
    ..We studied the association between the use of non-selective ns-NSAIDs, selective COX-2 inhibitors, or either of these NSAIDs, and the incidence of stroke-related hospitalization in elderly subjects...
  15. pmc Use of non-steroidal anti-inflammatory drugs and risk of incident myocardial infarction and heart failure, and all-cause mortality in the Australian veteran community
    Arduino A Mangoni
    Department of Clinical Pharmacology, School of Medicine, Flinders University, Australia
    Br J Clin Pharmacol 69:689-700. 2010
    ..We studied the association between either non-selective NSAIDs (ns-NSAIDs), selective COX-2 inhibitors, or any NSAID and risk of incident myocardial infarction (MI) and heart failure (HF), and all-cause mortality in elderly subjects...
  16. pmc Effects of pre- vs. intra-dialysis folic acid on arterial wave reflections and endothelial function in patients with end-stage renal disease
    Yuka Tochihara
    Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Adelaide, Australia
    Br J Clin Pharmacol 66:717-22. 2008
    ..We speculated that intra-HD, instead of pre-HD, F administration would provide beneficial effects on arterial wave reflections and endothelial function by preventing HD-induced F loss...
  17. doi Analysis of short-term reproducibility of arterial vasoreactivity by pulse-wave analysis after pharmacological challenge
    Biju Paul
    Department of Clinical Pharmacology, Flinders University and Flinders Medical Center, Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 36:49-54. 2009
    ..4. The poor reproducibility of changes in AIx following pharmacological challenge questions the use of this method in acute studies...
  18. ncbi Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure
    Andrew Rowland
    a Department of Clinical Pharmacology, Flinders University, Adelaide, Australia
    Expert Opin Drug Metab Toxicol 13:31-49. 2017
    ..If precision KI dosing can facilitate a fraction of the reported observational benefits, then substantial gains in patient outcomes will be derived in a cost-effective manner...
  19. pmc Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data
    Michael J Sorich
    Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, South Australia 5042, Australia
    Br J Cancer 114:1313-7. 2016
    ..Proteinuria is a common adverse effect of vascular endothelial growth factor targeted agents, particularly in metastatic renal cell carcinoma (mRCC). However, risk factors for proteinuria are poorly defined...
  20. ncbi Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease
    Carol Wadham
    Flinders University, Flinders Medical Centre, Department of Clinical Pharmacology, Adelaide, Australia
    Expert Opin Drug Metab Toxicol 5:303-19. 2009
    ..Suggestions for future basic and clinical research directions are also discussed...
  21. ncbi Influence of comorbidities and medication use on tilt table test outcome in elderly patients
    Biju Paul
    Department of Clinical Pharmacology, School of Medicine, Flinders University and Flinders Medical Centre, Adelaide, Australia
    Pacing Clin Electrophysiol 30:540-3. 2007
    ..However, preexisting comorbidities and medications affecting hemodynamic response might affect TTT outcome (i.e. presence or absence of vasomotor syncope). We studied the influence of these compounding factors on TTT outcome...
  22. doi Effects of red wine on established markers of arterial structure and function in human studies: current knowledge and future research directions
    Arduino A Mangoni
    Discipline of Clinical Pharmacology, School of Medicine, Flinders University and Flinders Medical Centre, Flinders Drive, Bedford Park, SA 5042, Australia
    Expert Rev Clin Pharmacol 6:613-25. 2013
    ..Suggestions for future research directions are also provided...
  23. pmc Non-selective nonsteroidal anti-inflammatory drugs and cardiovascular events: is aldosterone the silent partner in crime?
    Kathleen M Knights
    Department of Clinical Pharmacology, Flinders University, Bedford Park, Adelaide, Australia
    Br J Clin Pharmacol 61:738-40. 2006
    ..The question remains whether inhibition of aldosterone metabolism by non-selective NSAIDs is a casual or causal factor in NSAID-induced cardiovascular toxicity...
  24. pmc Optimized Cocktail Phenotyping Study Protocol Using Physiological Based Pharmacokinetic Modeling and In silico Assessment of Metabolic Drug-Drug Interactions Involving Modafinil
    Angela Rowland
    Department of Clinical Pharmacology, School of Medicine, Flinders University Adelaide, SA, Australia
    Front Pharmacol 7:517. 2016
    ..Using modafinil as a model compound, we sought to develop an optimized ICPP mDDI study protocol to evaluate the potential magnitude and clinical relevance of mDDIs using a physiologically based pharmacokinetic modeling approach...
  25. doi Angiotensin system inhibitors and survival in patients with metastatic renal cell carcinoma treated with VEGF-targeted therapy: A pooled secondary analysis of clinical trials
    Michael J Sorich
    Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, Australia
    Int J Cancer 138:2293-9. 2016
    ..In conclusion, use of ASIs at baseline was not a significant independent prognostic factor for improved survival in a pooled analysis of mRCC patients treated with pazopanib or sunitinib...
  26. ncbi High-resolution transthoracic echocardiography of the left anterior descending coronary artery: a novel noninvasive assessment of coronary vasoreactivity
    Rebecca Perry
    Cardiac Services, Flinders Medical Centre, Flinders University, Bedford Park, South Australia, Australia
    J Am Soc Echocardiogr 21:134-8. 2008
    ....
  27. ncbi Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity
    Kathleen M Knights
    Department of Clinical Pharmacology, Flinders University, Bedford Park, Adelaide, 5042 Australia
    Expert Rev Clin Pharmacol 3:769-76. 2010
    ..Data derived from in vitro models used to generate NSAID IC(50) values are discussed in the context of the difficulties in defining COX selectivity and hence understanding the toxicity of NSAIDs in current clinical use...
  28. pmc Patterns of Drug Use and Serum Sodium Concentrations in Older Hospitalized Patients: A Latent Class Analysis Approach
    Richard J Woodman
    Centre for Epidemiology and Biostatistics, School of Medicine, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia
    Drugs Real World Outcomes 3:383-391. 2016
    ..However, distinguishing their individual effects is particularly difficult in this population because of the high prevalence of polypharmacy and disease states that are per se associated with hyponatremia...
  29. doi Heat Waves, Drugs with Anticholinergic Effects, and Outcomes in Older Hospitalized Adults
    Arduino A Mangoni
    Department of Clinical Pharmacology, School of Medicine, Flinders University and Flinders Medical Centre, Adelaide, Australia
    J Am Geriatr Soc 64:1091-6. 2016
    ..To determine whether heat waves (HWs) affect exposure to drugs with anticholinergic effects (DACEs) on admission and the effect of such on length of stay (LOS) and in-hospital mortality in older adults...
  30. pmc Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: A systematic review and meta-analysis
    Kimberley Ruxton
    Department of Clinical Pharmacology, School of Medicine, Flinders University and Flinders Medical Centre, Bedford Park, SA, 5042, Australia
    Br J Clin Pharmacol 80:209-20. 2015
    ..The aim was to investigate associations between drugs with anticholinergic effects (DACEs) and cognitive impairment, falls and all-cause mortality in older adults...
  31. pmc The impact of traditional cardiovascular risk factors on cardiovascular outcomes in patients with rheumatoid arthritis: a systematic review and meta-analysis
    Leena R Baghdadi
    Department of Family and Community Medicine, King Saud University, Riyadh, Saudi Arabia, Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, Australia Flinders Centre for Epidemiology and Biostatistics, School of Medicine, Flinders University, Adelaide, Australia Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, Australia
    PLoS ONE 10:e0117952. 2015
    ..Rheumatoid arthritis (RA) is known to increase the risk of cardiovascular (CV) disease. However, the individual impact of traditional CV risk factors in RA is unknown...
  32. pmc Quality of requests for serum digoxin concentrations: experience from an Australian regional health service
    Chris Ellington
    Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, SA, Australia
    Br J Clin Pharmacol 63:623-7. 2007
    ..However, studies have focused on few information parameters. * A better knowledge of these issues might be useful to target appropriate areas of weakness within heathcare systems...
  33. doi Plasma erythromycin concentrations predict feeding outcomes in critically ill patients with feed intolerance
    Nam Q Nguyen
    Department of Gastroenterology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Crit Care Med 39:868-71. 2011
    ..This study aimed to evaluate the relationship between plasma erythromycin concentrations and feeding outcomes in critically ill patients...
  34. ncbi The emerging role of vascular endothelial growth factor (VEGF) in vascular homeostasis: lessons from recent trials with anti-VEGF drugs
    Shivshankar Thanigaimani
    Department of Clinical Pharmacology, Flinders University, Adelaide, Australia
    Curr Vasc Pharmacol 9:358-80. 2011
    ..A critical appraisal of the human studies on these drugs is provided. Furthermore, putative mechanisms for the onset of hypertension, the most common adverse cardiovascular effect, are discussed...
  35. ncbi An early drop in systolic blood pressure predicts a positive tilt table test in elderly patients with unexplained falls or syncope
    Derek Yiu
    Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia
    Age Ageing 35:183-5. 2006
  36. ncbi Lack of significant effects of methionine loading on endothelial function in elderly volunteers
    Simon R Hart
    Division of Clinical Neuroscience, University of Edinburgh, Western General Hospital, Edinburgh, Scotland EH4 2XU, United Kingdom
    Heart Lung Circ 15:358-61. 2006
    ....
  37. ncbi Outcome following mitral valve replacement in patients with mitral stenosis and moderately reduced left ventricular ejection fraction
    Arduino A Mangoni
    Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, MA 02114 3117, USA
    Eur J Cardiothorac Surg 22:90-4. 2002
    ..The effect of moderately reduced LV EF on outcome after mitral valve replacement (MVR) is not known...
  38. ncbi Determinants of failure to prescribe target doses of angiotensin-converting enzyme inhibitors for heart failure
    Juliet Manyemba
    Department of Health Care of the Elderly, Clinical Age Research Unit, Guy s King s and St Thomas School of Medicine, King s College Hospital, London SE5 9PJ, UK
    Eur J Heart Fail 5:693-6. 2003
  39. ncbi Effects of folic acid supplementation on psychomotor performance and hemorheology in healthy elderly subjects
    Rohan Pathansali
    Department of Health Care of the Elderly, Guy s, King s and St Thomas School of Medicine, King s College London, London SE5 9PJ, UK
    Arch Gerontol Geriatr 43:127-37. 2006
    ..Short-term folic acid supplementation does not enhance psychomotor performance or reduce blood viscosity in healthy elderly subjects with normal serum folic acid levels and preserved cognitive function...
  40. ncbi Programmable microchip monitoring of post-stroke pyrexia: effects of aspirin and paracetamol on temperature and infarct size in the rat
    Jeffrey J Legos
    GlaxoSmithKline, High Throughput Biology, Discovery Research, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406, USA
    J Neurosci Methods 113:159-66. 2002
    ..However, a full characterization of these pyretic changes and the effects of anti-pyretic drugs on outcome is not available...
  41. pmc Acute hypotensive effects of oral cisapride and erythromycin in healthy subjects
    Arduino A Mangoni
    Br J Clin Pharmacol 58:223-4. 2004
  42. ncbi Diastolic and pulse pressure: the old and the new?
    Arduino A Mangoni
    Hypertension 43:531-2. 2004
  43. ncbi Paradoxical vasodilation during lower body negative pressure in patients with vasodepressor carotid sinus syndrome
    Arduino A Mangoni
    Department of Health Care of the Elderly, Guy s, King s, and St Thomas School of Medicine, King s College, London, United Kingdom
    J Am Geriatr Soc 51:853-7. 2003
    ....