Murray Esler

Summary

Country: Australia

Publications

  1. ncbi request reprint Neural mechanisms and management of obesity-related hypertension
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Curr Cardiol Rep 10:456-63. 2008
  2. doi request reprint Mental stress and human cardiovascular disease
    Murray Esler
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia Electronic address
    Neurosci Biobehav Rev . 2016
  3. doi request reprint The future of renal denervation
    Murray Esler
    Baker IDI Heart and Diabetes Institute, Australia Electronic address
    Auton Neurosci . 2016
  4. doi request reprint Renal denervation for treatment of drug-resistant hypertension
    Murray Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia Electronic address
    Trends Cardiovasc Med 25:107-15. 2015
  5. doi request reprint Illusions of truths in the Symplicity HTN-3 trial: generic design strengths but neuroscience failings
    Murray Esler
    Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia Electronic address
    J Am Soc Hypertens 8:593-8. 2014
  6. doi request reprint The sympathetic nervous system in hypertension: back to the future?
    Murray Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Vic, 8008, Australia
    Curr Hypertens Rep 17:11. 2015
  7. doi request reprint Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension: 36 month results from the SYMPLICITY HTN-2 randomized clinical trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, Monash University, 75 Commercial Road, Melbourne, Victoria 3004, Australia
    Eur Heart J 35:1752-9. 2014
  8. doi request reprint Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, Victoria 3004, Australia
    Circulation 126:2976-82. 2012
  9. doi request reprint Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road, Central Melbourne, VIC 8008, Australia
    Lancet 376:1903-9. 2010
  10. doi request reprint The 2009 Carl Ludwig Lecture: Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management
    Murray Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Appl Physiol (1985) 108:227-37. 2010

Detail Information

Publications76

  1. ncbi request reprint Neural mechanisms and management of obesity-related hypertension
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Curr Cardiol Rep 10:456-63. 2008
    ..Perhaps more important is the requirement that chosen antihypertensives do not cause weight gain or insulin resistance...
  2. doi request reprint Mental stress and human cardiovascular disease
    Murray Esler
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia Electronic address
    Neurosci Biobehav Rev . 2016
    ..In patients with essential hypertension, stress biomarkers are present. The sympathetic nervous system is the usual mediator between these acute and chronic psychological substrates and cardiovascular disease...
  3. doi request reprint The future of renal denervation
    Murray Esler
    Baker IDI Heart and Diabetes Institute, Australia Electronic address
    Auton Neurosci . 2016
    ....
  4. doi request reprint Renal denervation for treatment of drug-resistant hypertension
    Murray Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia Electronic address
    Trends Cardiovasc Med 25:107-15. 2015
    ..Given this, and other difficulties in the execution of the trial relating to drug adherence, an idea mooted is that the US pivotal trial of the future may be in younger, untreated patients...
  5. doi request reprint Illusions of truths in the Symplicity HTN-3 trial: generic design strengths but neuroscience failings
    Murray Esler
    Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia Electronic address
    J Am Soc Hypertens 8:593-8. 2014
    ..Recently presented results from the Symplicity HTN-3 trialists confirm that renal denervation was not effectively or consistently achieved in the trial. ..
  6. doi request reprint The sympathetic nervous system in hypertension: back to the future?
    Murray Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Vic, 8008, Australia
    Curr Hypertens Rep 17:11. 2015
    ....
  7. doi request reprint Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension: 36 month results from the SYMPLICITY HTN-2 randomized clinical trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, Monash University, 75 Commercial Road, Melbourne, Victoria 3004, Australia
    Eur Heart J 35:1752-9. 2014
    ..The aim of this study was to determine long-term results of renal artery denervation for treatment of treatment-resistant hypertension in the SYMPLICITY HTN-2 study...
  8. doi request reprint Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, Victoria 3004, Australia
    Circulation 126:2976-82. 2012
    ..Longer-term follow-up, including 6-month crossover results, is now presented...
  9. doi request reprint Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road, Central Melbourne, VIC 8008, Australia
    Lancet 376:1903-9. 2010
    ..We aimed to assess effectiveness and safety of catheter-based renal denervation for reduction of blood pressure in patients with treatment-resistant hypertension...
  10. doi request reprint The 2009 Carl Ludwig Lecture: Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management
    Murray Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Appl Physiol (1985) 108:227-37. 2010
    ..With psychogenic heart disease and postural syncope syndromes, knowledge of the neural pathophysiology is emerging, but clinical translation remains for the future...
  11. doi request reprint The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension
    Murray Esler
    Baker IDI Heart and Diabetes Institute, Melbourne, Vic, Australia
    Exp Physiol 96:611-22. 2011
    ....
  12. doi request reprint Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
    ....
  13. ncbi request reprint Gender differences in sympathetic nervous activity: influence of body mass and blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 25:1411-9. 2007
    ..We tested whether the sympathetic nervous system was differently affected in men and women by the body mass index (BMI), BP, leptin and weight loss...
  14. ncbi request reprint Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor
    Murray Esler
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Stress 10:295-304. 2007
    ....
  15. ncbi request reprint Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertension 50:862-8. 2007
    ..The underlying central nervous system mechanism and the adverse consequences of the 2 modes of sympathetic activation may differ...
  16. ncbi request reprint Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function
    Nina Eikelis
    Baker Heart Research Institute, Melbourne University, Melbourne, Victoria 8008, Australia
    Am J Physiol Endocrinol Metab 286:E744-52. 2004
    ..9 +/- 1.4 vs. 5.3 +/- 2.2 ng/min (P = 0.042). These results suggest that leptin is released within the brain and at an increased rate in obese humans, in whom activation of brain serotonergic and NPY mechanisms also exists...
  17. doi request reprint Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 1:103-9. 2008
    ..Clinical observations in patients with postural tachycardia syndrome (POTS) suggest abnormal sympathetic nervous system activity and a dysfunction of the norepinephrine (NE) transporter (NET)...
  18. ncbi request reprint Interactions between leptin and the human sympathetic nervous system
    Nina Eikelis
    Baker Heart Research Institute and Alfred Baker Medical Unit, Alfred Hospital, Melbourne, Australia
    Hypertension 41:1072-9. 2003
    ....
  19. doi request reprint Chronic mental stress is a cause of essential hypertension: presence of biological markers of stress
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:498-502. 2008
    ..This judgement was reached after consideration of the epidemiological evidence, but in particular after review of the specific elements of the neural pathophysiology of essential hypertension, described above...
  20. doi request reprint Dyslipidemia is associated with sympathetic nervous activation and impaired endothelial function in young females
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Australia
    Am J Hypertens 26:250-6. 2013
    ..We therefore investigated whether both endothelial and sympathetic functions may be impaired in young females with abnormal plasma cholesterol levels...
  21. doi request reprint Recurrent postural vasovagal syncope: sympathetic nervous system phenotypes
    Gautam Vaddadi
    Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 4:711-8. 2011
    ..We investigated neural circulatory control in these 2 phenotypes...
  22. doi request reprint Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 56:351-8. 2010
    ..Sympathetic activity is closely associated with cardiovascular and renal alterations observed in these subjects...
  23. ncbi request reprint The neuronal noradrenaline transporter, anxiety and cardiovascular disease
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    J Psychopharmacol 20:60-6. 2006
    ....
  24. doi request reprint Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 58:43-50. 2011
    ..These responses may represent a combination of peripheral (baroreflex-mediated) and central effects of ghrelin...
  25. doi request reprint Association between the sympathetic firing pattern and anxiety level in patients with the metabolic syndrome and elevated blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    J Hypertens 28:543-50. 2010
    ....
  26. ncbi request reprint Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 22:1529-34. 2004
    ..Acute sympathetic nervous activation is a proven trigger for adverse cardiovascular events. Accordingly, antihypertensive drugs inhibiting sympathetic outflow represent a theoretically attractive therapeutic option...
  27. ncbi request reprint Effect of angiotensin II receptor blockade on autonomic nervous system function in patients with essential hypertension
    Henry Krum
    National Health and Medical Research Council of Australia, Centre of Clinical Research Excellence in Therapeutics, Monash University, Melbourne, VIC 3004, Australia
    Am J Physiol Heart Circ Physiol 290:H1706-12. 2006
    ..We conclude that sympathetic nervous inhibition is not a major component of the blood pressure-lowering action of ARBs in essential hypertension...
  28. ncbi request reprint OS 28-02 RENAL DENERVATION ALTERS ADIPOKINE LEVELS IN PATIENTS WITH RESISTANT HYPERTENSION
    Markus Schlaich
    1Dobney Hypertension Centre, University of Western Australia, Australia 2Department of Cardiology, Alfred Hospital Melbourne, Australia 3Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute, Australia
    J Hypertens 34:e251. 2016
    ..The aim of this study was to examine the effect of RDN on adipokines. In particular, whether BP reduction, associated with RDN treatment, has a favorable outcome on adipokine profile in patients with resistant hypertension (RH)...
  29. doi request reprint Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome
    Richard Bayles
    Baker IDI Heart and Diabetes Institute, The University of Melbourne, Melbourne, Victoria 3004, Australia
    Arterioscler Thromb Vasc Biol 32:1910-6. 2012
    ..A coding mutation in the norepinephrine transporter gene (SLC6A2) sequence has been reported in 1 family kindred only. The goal of the present study was to further characterize the role and regulation of the SLC6A2 gene in POTS...
  30. doi request reprint Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
    Henry Krum
    Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic, Australia
    Lancet 373:1275-81. 2009
    ....
  31. ncbi request reprint Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress
    Murray Esler
    Baker Medical Research Institute, Melbourne, Australia
    Biogerontology 3:45-9. 2002
    ..Sympathetic nervous responses with stressors were augmented. Conversely, adrenal medullary release of epinephrine was subnormal in the elderly, at rest and during stress...
  32. ncbi request reprint NPY and NPY Y1 receptor effects on noradrenaline overflow from the rat brain in vitro
    Jacqueline A Hastings
    Baker Heart Research Institute, Human Neurotransmitter Laboratory, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Regul Pept 120:107-12. 2004
    ....
  33. doi request reprint Single-unit sympathetic discharge pattern in pathological conditions associated with elevated cardiovascular risk
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:503-7. 2008
    ..4. Single-unit methodology may represent a major step forward in the understanding of the link between disturbed sympathetic nerve firing and associated cardiovascular risk...
  34. ncbi request reprint Sympathetic neuronal regulation of the heart in aging and heart failure
    David Kaye
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, VIC 8008, Australia
    Cardiovasc Res 66:256-64. 2005
    ..Our conclusion is, on balance, that this proposition is not supported by the available evidence...
  35. ncbi request reprint Mechanisms of sympathetic activation in obesity-related hypertension
    Murray Esler
    Baker Heart Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Hypertension 48:787-96. 2006
  36. ncbi request reprint ISH NIA OS-01 THE microRNA miR-19a-3p BINDS TO A POLYMORPHISM IN THE GENE FOR THE NORADRENALINE TRANSPORTER AND MAY INCREASE THE RISK OF CARDIOVASCULAR AND PSYCHIATRIC DISEASE
    Francine Marques
    aDepartment of Heart Failure Research Group, Baker IDI Heart and Diabetes Institute, Australia bDepartment of Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Research Institute, Australia cDepartment of Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Research Institute, Australia dDepartment of Dobney Hypertension Centre, University of Western Australia, Australia
    J Hypertens 34:e42. 2016
    ..The aim of this study was to determine whether rs7194256 (C/T), a SNP in the 3' untranslated region (UTR) of the NET gene, is associated with diseases associated with NET dysfunction, and to elucidate the mechanism involved...
  37. ncbi request reprint The neurobiology of human obesity
    Nina Eikelis
    Baker Heart Research Institute, Melbourne, Australia
    Exp Physiol 90:673-82. 2005
    ..Brain leptin release has the potential to override the peripheral, adipocyte leptin system...
  38. ncbi request reprint Management of hypertension complicated by psychiatric comorbidity
    Murray Esler
    Baker Heart Research Institute, Royal Women s Hospital, Melbourne, Australia
    J Clin Hypertens (Greenwich) 9:708-13. 2007
  39. pmc Methylation of the SLC6a2 gene promoter in major depression and panic disorder
    Richard Bayles
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    PLoS ONE 8:e83223. 2013
    ..Further in-depth analysis of alternative mechanisms of transcriptional regulation of the SLC6a2 gene in human health and disease would be of value. ..
  40. ncbi request reprint Cardiac sympathetic nerve biology and brain monoamine turnover in panic disorder
    Murray Esler
    Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Ann N Y Acad Sci 1018:505-14. 2004
    ....
  41. ncbi request reprint Effects of dietary weight loss on sympathetic activity and cardiac risk factors associated with the metabolic syndrome
    Nora E Straznicky
    Cardiovascular Nutrition Laboratory, Wynn Domain, Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 90:5998-6005. 2005
    ....
  42. ncbi request reprint OS 19-01 BLOOD PRESSURE INDEPENDENT EFFECTS OF RENAL DENERVATION ON THE DECLINE OF KIDNEY FUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE
    Dagmara Hering
    1Dobney Hypertension Centre, The University of Western Australia Royal Perth Hospital Unit, Australia 2Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia 3Heart Centre, Alfred Hospital, Melbourne, Australia
    J Hypertens 34:e228. 2016
    ..This study investigated the effects of RDN on renal function and BP in CKD patients (eGFR ≤ 60 ml/min/1.73 m) out to 24 months post procedure...
  43. ncbi request reprint Differentiation in the effects of the angiotensin II receptor blocker class on autonomic function
    Murray Esler
    Baker Medical Research Institute, Commercial Road, Prahran 3181, Melbourne, Australia
    J Hypertens Suppl 20:S13-9. 2002
    ..A reduction in noradrenaline spillover disproportionate to any possible fall in nerve firing would document the presence of presynaptic antagonism of noradrenaline release...
  44. pmc Single-unit analysis of sympathetic nervous discharges in patients with panic disorder
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria, Australia
    J Physiol 570:637-43. 2006
    ..Quantification from single vasoconstrictor unit recording provides evidence of a disturbed sympathetic firing pattern in patients with panic disorder...
  45. ncbi request reprint The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover
    Murray Esler
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Am J Physiol Regul Integr Comp Physiol 282:R909-16. 2002
    ....
  46. doi request reprint The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components
    Nora E Straznicky
    Laboratories of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 96:E503-8. 2011
    ..Sympathetic nervous system (SNS) overactivity participates in both the pathogenesis and adverse clinical complications of metabolic syndrome (MetS) obesity...
  47. doi request reprint New therapeutic approaches to resistant hypertension
    Markus P Schlaich
    Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008, Australia
    Curr Hypertens Rep 12:296-302. 2010
    ..In this context, several lines of research have generated promising results based on both novel pharmacologic and device-based approaches that may more effectively treat resistant hypertension and its adverse consequences in the future...
  48. doi request reprint The role of sympathetic nervous activity in renal injury and end-stage renal disease
    Kazuko Masuo
    Nucleus Network Ltd, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Hypertens Res 33:521-8. 2010
    ..These insights may be useful to improve prevention and treatment of renal injury in these patients...
  49. doi request reprint Persistence of muscle sympathetic nerve activity during vasovagal syncope
    Gautam Vaddadi
    Human Neurotransmitter Laboratory, BakerIDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia
    Eur Heart J 31:2027-33. 2010
    ..To determine whether sympathetic nerve firing to skeletal muscle vasculature is withdrawn during vasovagal syncope (VVS) precipitated by passive graded head-up tilt (HUT) table testing...
  50. doi request reprint Blunted sympathetic neural response to oral glucose in obese subjects with the insulin-resistant metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters and Heart Failure Division, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Am J Clin Nutr 89:27-36. 2009
    ..Glucose ingestion stimulates sympathetic nervous system (SNS) activity in lean subjects, whereas blunted responses have been reported in the obese...
  51. pmc Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:1126-32. 2009
    ..The purpose of this study was to examine the effects of weight loss on sympathetic nervous system responsiveness to glucose ingestion in obese subjects with metabolic syndrome, in whom such responses are reportedly blunted...
  52. doi request reprint Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population
    Kazuko Masuo
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 31:1093-100. 2008
    ..We therefore hypothesize that leptin-receptor play a role in the development of obesity through leptin resistance and blunted leptin-mediated sympathetic nerve activity...
  53. pmc Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 59:71-9. 2010
    ..This study was conducted to examine the effects of lifestyle interventions (weight loss alone or together with exercise) on SNS function...
  54. ncbi request reprint Cardiovascular and renal complications of type 2 diabetes in obesity: role of sympathetic nerve activity and insulin resistance
    Kazuko Masuo
    Nucleus Network Ltd, Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria 3004, Australia
    Curr Diabetes Rev 6:58-67. 2010
    ..Further, to clarify the pathogenesis and mechanisms of the association between obesity, diabetes, and hypertension may lead to reductions in cardiovascular and renal risk...
  55. ncbi request reprint Mediators of sympathetic activation in metabolic syndrome obesity
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    Curr Hypertens Rep 10:440-7. 2008
    ..Because chronic sympathetic activation contributes to hypertension and its target-organ damage, sympathoinhibition remains an important goal in the therapeutic management of the metabolic syndrome...
  56. ncbi request reprint Increased suicide rate in the middle-aged and its association with hours of sunlight
    Gavin Lambert
    Human Neurotransmitter Laboratory, Baker Medical Research Institute, Australia
    Am J Psychiatry 160:793-5. 2003
    ....
  57. ncbi request reprint Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy
    Markus P Schlaich
    Human Neurotransmitter Laboratory, Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria 8008, Australia
    Circulation 108:560-5. 2003
    ..Sympathetic activation has been suggested to contribute to LV hypertrophy, but this has not yet been conclusively validated in humans...
  58. ncbi request reprint Sympathetic and cardiac baroreflex function in panic disorder
    Elisabeth A Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Hypertens 20:2445-51. 2002
    ..The cause is not known, but possibly involves sympathetic nervous activation. In this study, we evaluated the arterial baroreflex control of vascular sympathetic nervous outflow and cardiac baroreflex function in panic disorder patients...
  59. doi request reprint Peripheral chemoreflex activation contributes to sympathetic baroreflex impairment in chronic heart failure
    Fabien Despas
    Institut National de la Sante et de la Recherche Medicale, UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
    J Hypertens 30:753-60. 2012
    ..Chemoreflex-mediated sympathetic activation contributes to both initiation and progression of chronic heart failure (CHF)...
  60. ncbi request reprint Influence of leptin on neurotransmitter overflow from the rat brain in vitro
    Jacqueline A Hastings
    Baker Medical Research Institute, Human Neurotransmitter Laboratory, P O Box 6492, Victoria 8008, Melbourne, Australia
    Regul Pept 103:67-74. 2002
    ..This study lends support to the notion of a complex interaction of the leptinergic and brain neurotransmitters involved in the control of feeding and energy metabolism...
  61. doi request reprint Autonomic control of the aging heart
    David M Kaye
    Heart Failure Research Group, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne VIC 8008, Australia
    Neuromolecular Med 10:179-86. 2008
    ..Attention to the mechanisms of these changes and the development of appropriate therapies may serve to reduce the added influence of age on outcome in patients experiencing cardiovascular disease...
  62. ncbi request reprint Specific serotonin reuptake inhibition in major depressive disorder adversely affects novel markers of cardiac risk
    Tye Dawood
    Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 30:285-93. 2007
    ..Mechanisms potentially responsible for generating cardiac risk in patients treated with selective serotonin reuptake inhibitors may need to be therapeutically targeted to reduce the incidence of coronary heart disease in this population...
  63. ncbi request reprint Chronic atrial fibrillation does not influence the magnitude of sympathetic overactivity in patients with heart failure
    Paul A Gould
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Eur Heart J 24:1657-62. 2003
    ..In this study we sought to assess the influence of atrial fibrillation (AF) on sympathetic nervous system overactivity in congestive heart failure (CHF) patients...
  64. ncbi request reprint Raised sympathetic nerve activity in heart failure and central sleep apnea is due to heart failure severity
    Darren Mansfield
    Department of Respiratory Medicine and Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Circulation 107:1396-400. 2003
    ..We measured awake total body and cardiac NE spillover and related these to measurements of cardiac hemodynamics and apnea severity in CHF patients with CSA, with normal breathing, and with obstructive sleep apnea (CHF-OSA)...
  65. ncbi request reprint Regional sympathetic effects of low-dose clonidine in heart failure
    Anuradha Aggarwal
    Baker Medical Research Institute, University of Melbourne, Melbourne, Victoria, Australia
    Hypertension 41:553-7. 2003
    ..In addition to the beneficial effects of antiadrenergic therapy in the heart, the renal sympatholytic effect may counter the salt and water retention that is a hallmark of the condition...
  66. ncbi request reprint Acute electrophysiologic effects of intravenous amiodarone are independent of a sympatholytic action in humans
    Deepak Haikerwal
    Baker Heart Research Institute, Melbourne, Australia
    J Cardiovasc Pharmacol 41:760-5. 2003
    ..Acute IV AM did not exert a sympatholytic action in humans, with no attenuation in hemodynamic or NA response to handgrip or increase in DHPG production, despite producing an electrophysiologic response...
  67. doi request reprint Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome
    Abdul Waheed Khan
    Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia Electronic address
    Neurosci Biobehav Rev . 2016
    ..In this article, we discuss the epigenetic mechanisms involved in SLC6A2 repression and highlight the potential therapeutic application of targeting these mechanisms in POTS...
  68. doi request reprint Reverse cardiac remodeling after renal denervation: Atrial electrophysiologic and structural changes associated with blood pressure lowering
    Alex J A McLellan
    Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia Cardiology Department, Royal Melbourne Hospital, Victoria, Australia Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Victoria, Australia
    Heart Rhythm 12:982-90. 2015
    ..Hypertension is the most common modifiable risk factor associated with atrial fibrillation...
  69. ncbi request reprint Beta-adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure
    David M Kaye
    Heart Centre, Alfred Hospital and Baker Medical Reserach Insititute, Melbourne, Victoria, Australia
    Pharmacogenetics 13:379-82. 2003
    ..These data demonstrate a significant influence of beta2AR genotype in the response to carvedilol in CHF patients. Accordingly, determination of beta2AR status may be of value in the tailoring of individual therapy in patients with CHF...
  70. ncbi request reprint Norepinephrine turnover is increased in suprabulbar subcortical brain regions and is related to whole-body sympathetic activity in human heart failure
    Anuradha Aggarwal
    Baker Medical Research Institute, Melbourne, Australia
    Circulation 105:1031-3. 2002
    ....
  71. doi request reprint Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy
    David A Barton
    Department of Psychological Medicine, Alfred Hospital, Monash University, Melbourne, Victoria, Australia
    Arch Gen Psychiatry 65:38-46. 2008
    ..The biological basis for the development of major depressive disorder (MDD) remains incompletely understood...
  72. doi request reprint Atrial fibrillation is associated with decreased cardiac sympathetic response to isometric exercise in CHF in comparison to sinus rhythm
    Paul A Gould
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne, Australia
    Pacing Clin Electrophysiol 31:1125-9. 2008
    ..In previous studies, we have demonstrated cardiac baroreceptor abnormalities in association with AF and CHF. In this study, we sought to examine the effect of cardiac rhythm on the cardiac sympathetic response to exercise in CHF...
  73. ncbi request reprint Oestrogen supplementation attenuates responses to psychological stress in elderly men rendered hypogonadal after treatment for prostate cancer
    Paul A Komesaroff
    Hormone and Vasculature Laboratory and Alfred and Baker Medical Center, Baker Medical Research Institute and Alfred Hospital, Melbourne, Victoria, Australia
    Clin Endocrinol (Oxf) 56:745-53. 2002
    ....
  74. ncbi request reprint Divergent effects of ANP and BNP in acute heart failure: evidence for a putative BNP-selective receptor?
    Hans Peter Brunner-La Rocca
    Baker Medical Research Institute, Melbourne, Australia
    J Hypertens 20:1195-201. 2002
    ..Our aim was to compare the haemodynamic actions of ANP with BNP, using a classical vasodilator as the control, in greyhound dogs with acute pacing-induced HF...
  75. ncbi request reprint Atrial fibrillation impairs cardiac sympathetic response to baroreceptor unloading in congestive heart failure
    Paul A Gould
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne VIC 8008, Australia
    Eur Heart J 26:2562-7. 2005
    ..Specifically, we aimed to determine whether AF impaired cardiac sympathetic response to baroreceptor unloading in comparison to sinus rhythm (SR) in CHF...