T J Cole

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi request reprint GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant
    T J Cole
    Baker Medical Research Institute, Commercial Road, Prahran, 3181, Victoria, Australia
    Mol Cell Endocrinol 173:193-202. 2001
  2. ncbi request reprint The glucocorticoid receptor is essential for maintaining basal and dexamethasone-induced repression of the murine corticosteroid-binding globulin gene
    T J Cole
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Mol Cell Endocrinol 154:29-36. 1999
  3. ncbi request reprint Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling
    J F Purton
    Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria, Australia
    Immunity 13:179-86. 2000
  4. ncbi request reprint Stress-free T-cell development: glucocorticoids are not obligatory
    D I Godfrey
    Monash University Medical School, Department of Pathology and Immunology, Commercial Road, VIC 3181, Prahran, Australia
    Immunol Today 21:606-11. 2000
  5. ncbi request reprint The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action
    A Bhargava
    Baker Medical Research Institute, Melbourne 8008, Australia
    Endocrinology 142:1587-94. 2001
  6. ncbi request reprint Cardiac steroidogenesis in the normal and failing heart
    M J Young
    Baker Medical Research Institute, Prahran, Victoria 3181, Australia
    J Clin Endocrinol Metab 86:5121-6. 2001
  7. ncbi request reprint Expression of the 11beta-hydroxysteroid dehydrogenase 2 gene in the mouse
    X L Moore
    Baker Medical Research Institute, Commercial Road, Prahran, Victoria, Australia
    Kidney Int 57:1307-12. 2000
  8. ncbi request reprint The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver
    E G Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Drug Metab Dispos 28:268-78. 2000
  9. ncbi request reprint The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization
    T J Cole
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Genomics 13:974-82. 1992
  10. ncbi request reprint Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells
    S Finotto
    Neuroanatomy, University of Heidelberg, D 69120 Heidelberg, Germany
    Development 126:2935-44. 1999

Collaborators

Detail Information

Publications20

  1. ncbi request reprint GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant
    T J Cole
    Baker Medical Research Institute, Commercial Road, Prahran, 3181, Victoria, Australia
    Mol Cell Endocrinol 173:193-202. 2001
    ..Thus although the surviving adult homozygous GRKO mice express a dexamethasone-binding GR fragment, their classic target tissues remain profoundly glucocorticoid insensitive...
  2. ncbi request reprint The glucocorticoid receptor is essential for maintaining basal and dexamethasone-induced repression of the murine corticosteroid-binding globulin gene
    T J Cole
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Mol Cell Endocrinol 154:29-36. 1999
    ..These results indicate that in mice, GR is essential for maintaining the basal level of CBG gene expression in the liver, and is also required for dexamethasone-induced repression of the CBG gene in the adult...
  3. ncbi request reprint Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling
    J F Purton
    Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria, Australia
    Immunity 13:179-86. 2000
    ..In contrast to earlier reports, these data demonstrate that GR signaling is not essential for intrathymic T cell development or selection...
  4. ncbi request reprint Stress-free T-cell development: glucocorticoids are not obligatory
    D I Godfrey
    Monash University Medical School, Department of Pathology and Immunology, Commercial Road, VIC 3181, Prahran, Australia
    Immunol Today 21:606-11. 2000
    ..The most recent approach, using GR knockout (GR(-/-)) mice, indicates that GR signaling is, in fact, dispensable in this entire process...
  5. ncbi request reprint The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action
    A Bhargava
    Baker Medical Research Institute, Melbourne 8008, Australia
    Endocrinology 142:1587-94. 2001
    ....
  6. ncbi request reprint Cardiac steroidogenesis in the normal and failing heart
    M J Young
    Baker Medical Research Institute, Prahran, Victoria 3181, Australia
    J Clin Endocrinol Metab 86:5121-6. 2001
    ..The exact cellular location of steroid synthesis in the failing human heart remains to be established...
  7. ncbi request reprint Expression of the 11beta-hydroxysteroid dehydrogenase 2 gene in the mouse
    X L Moore
    Baker Medical Research Institute, Commercial Road, Prahran, Victoria, Australia
    Kidney Int 57:1307-12. 2000
    ....
  8. ncbi request reprint The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver
    E G Schuetz
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Drug Metab Dispos 28:268-78. 2000
    ..Thus, there are distinctly different essential requirements of CYP3A, CYP2B, and P-450 reductase genes for the glucocorticoid receptor in their induction by steroids and drugs...
  9. ncbi request reprint The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization
    T J Cole
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Genomics 13:974-82. 1992
    ..6 kb. The CREB gene was found to be single copy in the mouse and well conserved through evolution. Finally Creb-1, the CREB locus, was mapped to the proximal region of mouse chromosome 1...
  10. ncbi request reprint Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells
    S Finotto
    Neuroanatomy, University of Heidelberg, D 69120 Heidelberg, Germany
    Development 126:2935-44. 1999
    ..These data strongly suggest that the dogma of an essential role of glucocorticoid signalling for the development of chromaffin cells must be abandoned...
  11. ncbi request reprint Hippocampal cell responses in mice with a targeted glucocorticoid receptor gene disruption
    W Hesen
    Department of Experimental Zoology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 16:6766-74. 1996
    ..These findings exemplify the use of GR knockout mice for the study of cellular properties in the brain. Further substantiation of the observations, however, awaits the development of site-specific, inducible GR knockouts...
  12. pmc At least three promoters direct expression of the mouse glucocorticoid receptor gene
    U Strahle
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Proc Natl Acad Sci U S A 89:6731-5. 1992
    ..In contrast to a conservation of exon-intron structure, differences in promoter organization suggest a divergence between the evolution of regulatory and coding regions among members of the steroid receptor super-family...
  13. pmc Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors
    E Hummler
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Proc Natl Acad Sci U S A 91:5647-51. 1994
    ....
  14. pmc Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes
    S Ruppert
    German Cancer Research Center, Institute of Cell and Tumor Biology, Heidelberg
    EMBO J 11:1503-12. 1992
    ....
  15. ncbi request reprint Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
    T J Cole
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Genes Dev 9:1608-21. 1995
    ....
  16. pmc Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism
    S Berger
    Division Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 95:9424-9. 1998
    ..MR knockout mice will be a suitable tool for the search of these genes...
  17. ncbi request reprint Cloning of the mouse 11 beta-hydroxysteroid dehydrogenase type 2 gene: tissue specific expression and localization in distal convoluted tubules and collecting ducts of the kidney
    T J Cole
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Endocrinology 136:4693-6. 1995
    ..11 beta-HSD2 therefore appears to act in a protective role to exclude glucocorticoids from mineralocorticoid receptors in the kidney...
  18. ncbi request reprint Molecular genetic analysis of glucocorticoid signaling during mouse development
    T J Cole
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Steroids 60:93-6. 1995
    ..The majority of GR mutants die shortly after birth and analysis so far has revealed defects in lung, liver, and adrenal function...
  19. ncbi request reprint Molecular genetic analysis of glucocorticoid and mineralocorticoid signaling in development and physiological processes
    S A Berger
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
    Steroids 61:236-9. 1996
    ..Weightloss precedes death of homozygous mutant mice and is correlated with an increase in the haematocrit. As a consequence of this mutation, plasma levels of renin and aldosterone are high elevated...
  20. ncbi request reprint Birth season and environmental influences on patterns of thymic growth in rural Gambian infants
    A C Collinson
    MRC Keneba, MRC Laboratories, The Gambia
    Acta Paediatr 92:1014-20. 2003
    ..This study tested whether thymus size in rural Gambian infants is affected by birth season, defined as January-June (harvest, few infections) versus July-December (hungry, high infectious load)...