David J Handelsman

Summary

Affiliation: ANZAC Research Institute
Country: Australia

Publications

  1. ncbi Designer androgens in sport: when too much is never enough
    David J Handelsman
    ANZAC Research Institute, Sydney, NSW 2139, Australia
    Sci STKE 2004:pe41. 2004
  2. doi Estimating age-specific trends in circulating testosterone and sex hormone-binding globulin in males and females across the lifespan
    David J Handelsman
    Andrology Department, Concord Hospital, NSW, Australia ANZAC Research Institute, University of Sydney, Concord Hospital, NSW, Australia
    Ann Clin Biochem 53:377-84. 2016
  3. doi Performance of mass spectrometry steroid profiling for diagnosis of polycystic ovary syndrome
    D J Handelsman
    ANZAC Research Institute, University of Sydney, Concord Hospital, NSW 2139, Australia
    Hum Reprod 32:418-422. 2017
  4. doi Detection and effects on serum and urine steroid and LH of repeated GnRH analog (leuprolide) stimulation
    David J Handelsman
    Andrology Department, Concord Hospital, Sydney, NSW 2139, Australia ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia Electronic address
    J Steroid Biochem Mol Biol 141:113-20. 2014
  5. ncbi Global trends in testosterone prescribing, 2000-2011: expanding the spectrum of prescription drug misuse
    David J Handelsman
    ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, NSW, Australia
    Med J Aust 199:548-51. 2013
  6. pmc The study design and methodology for the ARCHER study--adolescent rural cohort study of hormones, health, education, environments and relationships
    Katharine Steinbeck
    Academic Department of Adolescent Medicine, University of Sydney, at Children s Hospital, Westmead, Sydney NSW 2145, Australia
    BMC Pediatr 12:143. 2012
  7. pmc Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra
    Tertia D Purves-Tyson
    Schizophrenia Research Institute, Sydney 2021, Australia
    BMC Neurosci 13:95. 2012
  8. ncbi Pharmacoepidemiology of testosterone prescribing in Australia, 1992-2010
    David J Handelsman
    ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 196:642-5. 2012
  9. pmc Determinants of male reproductive health disorders: the Men in Australia Telephone Survey (MATeS)
    Carol A Holden
    Andrology Australia, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    BMC Public Health 10:96. 2010
  10. ncbi Optimal power transformations for analysis of sperm concentration and other semen variables
    David J Handelsman
    ANZAC Research Institute and Department of Andrology, Concord Hospital, University of Sydney, Sydney, Australia
    J Androl 23:629-34. 2002

Detail Information

Publications147 found, 100 shown here

  1. ncbi Designer androgens in sport: when too much is never enough
    David J Handelsman
    ANZAC Research Institute, Sydney, NSW 2139, Australia
    Sci STKE 2004:pe41. 2004
    ..This will require the deployment of generic catch-all tests, such as sensitive and specific in vitro androgen bioassays, coupled with the development of mass spectrometry-based tests for specific doping agents...
  2. doi Estimating age-specific trends in circulating testosterone and sex hormone-binding globulin in males and females across the lifespan
    David J Handelsman
    Andrology Department, Concord Hospital, NSW, Australia ANZAC Research Institute, University of Sydney, Concord Hospital, NSW, Australia
    Ann Clin Biochem 53:377-84. 2016
    ..Age-specific trends of serum testosterone and sex hormone-binding globulin across the full lifespan have not been reported...
  3. doi Performance of mass spectrometry steroid profiling for diagnosis of polycystic ovary syndrome
    D J Handelsman
    ANZAC Research Institute, University of Sydney, Concord Hospital, NSW 2139, Australia
    Hum Reprod 32:418-422. 2017
    ..How well does multi-analyte steroid mass spectrometry (MS) profiling classify women with and without polycystic ovary syndrome (PCOS)?..
  4. doi Detection and effects on serum and urine steroid and LH of repeated GnRH analog (leuprolide) stimulation
    David J Handelsman
    Andrology Department, Concord Hospital, Sydney, NSW 2139, Australia ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia Electronic address
    J Steroid Biochem Mol Biol 141:113-20. 2014
    ..It is concluded that leuprolide stimulation of endogenous testosterone is reproducible after a 10-day interval, is not masked by ND and is reliably detected by urine leuprolide or M1 measurement for at least 1 day after administration. ..
  5. ncbi Global trends in testosterone prescribing, 2000-2011: expanding the spectrum of prescription drug misuse
    David J Handelsman
    ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, NSW, Australia
    Med J Aust 199:548-51. 2013
    ..To provide the first multinational survey of temporal trends in testosterone prescribing, given that anecdotal evidence indicates that it is increasing in some countries, including Australia...
  6. pmc The study design and methodology for the ARCHER study--adolescent rural cohort study of hormones, health, education, environments and relationships
    Katharine Steinbeck
    Academic Department of Adolescent Medicine, University of Sydney, at Children s Hospital, Westmead, Sydney NSW 2145, Australia
    BMC Pediatr 12:143. 2012
    ..This study has been designed to provide evidence on the relationship between reproductive hormones and the tempo of their rise to adult levels, and adolescent behaviour, health and wellbeing...
  7. pmc Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra
    Tertia D Purves-Tyson
    Schizophrenia Research Institute, Sydney 2021, Australia
    BMC Neurosci 13:95. 2012
    ..We hypothesized that adolescent testosterone would regulate sex steroid signaling through regulation of ER and AR mRNAs and through modulation of aromatase and 5α-reductase mRNA levels...
  8. ncbi Pharmacoepidemiology of testosterone prescribing in Australia, 1992-2010
    David J Handelsman
    ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 196:642-5. 2012
    ..To describe patterns of testosterone prescribing in Australia over the past two decades by state or territory and by product type...
  9. pmc Determinants of male reproductive health disorders: the Men in Australia Telephone Survey (MATeS)
    Carol A Holden
    Andrology Australia, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    BMC Public Health 10:96. 2010
    ....
  10. ncbi Optimal power transformations for analysis of sperm concentration and other semen variables
    David J Handelsman
    ANZAC Research Institute and Department of Andrology, Concord Hospital, University of Sydney, Sydney, Australia
    J Androl 23:629-34. 2002
    ..In addition, the power transformation has an important practical advantage over the logarithmic transformation in the appropriate handling of zeros (azoospermia), a regular and important features of such data sets in practice...
  11. ncbi 11: Androgen deficiency and replacement therapy in men
    David J Handelsman
    ANZAC Research Institute, Concord Hospital, Sydney, NSW
    Med J Aust 180:529-35. 2004
    ..There remains no convincing evidence that androgen therapy is either effective treatment or safe for older men unless they have frank androgen deficiency...
  12. ncbi Trends and regional differences in testosterone prescribing in Australia, 1991-2001
    David J Handelsman
    ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, NSW 2139, Australia
    Med J Aust 181:419-22. 2004
    ..To analyse temporal trends and geographical variations in testosterone prescribing in Australia...
  13. ncbi Andropause: invention, prevention, rejuvenation
    David J Handelsman
    Department of Andrology, Concord Hospital, ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia
    Trends Endocrinol Metab 16:39-45. 2005
    ..This review appraises current knowledge with a focus on the questionable basis for using androgen therapy to improve male reproductive health during aging...
  14. ncbi Clinical review: The rationale for banning human chorionic gonadotropin and estrogen blockers in sport
    David J Handelsman
    ANZAC Research Institute, University of Sydney, Department of Andrology, Concord Hospital, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 91:1646-53. 2006
    ....
  15. ncbi Testosterone: use, misuse and abuse
    David J Handelsman
    ANZAC Research Institute, Concord Hospital, Sydney, NSW, Australia
    Med J Aust 185:436-9. 2006
    ..Despite ongoing androgen misuse and abuse, testosterone remains under-prescribed for younger men with classical androgen deficiency that frequently remains undiagnosed...
  16. ncbi Update in andrology
    David J Handelsman
    Department of Andrology, Concord Hospital, ANZAC Research Institute, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 92:4505-11. 2007
    ..This is an invited review based on a presentation at the 2007 Annual Scientific Meeting of The Endocrine Society...
  17. doi Androgen abuse in sports
    David J Handelsman
    ANZAC Research Institute, University of Sydney and Department of Andrology, Concord Hospital, Sydney, NSW 2139, Australia
    Asian J Androl 10:403-15. 2008
    ....
  18. pmc Indirect androgen doping by oestrogen blockade in sports
    D J Handelsman
    ANZAC Research Institute and Department of Andrology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia
    Br J Pharmacol 154:598-605. 2008
    ..The physiological and pharmacological basis for the effects of oestrogen blockade in men, but not women, are reviewed...
  19. doi Effects of recombinant human LH and hCG on serum and urine LH and androgens in men
    David J Handelsman
    Andrology Department, Concord Hospital, ANZAC Research Institute, University of Sydney, Sydney NSW, Australia
    Clin Endocrinol (Oxf) 71:417-28. 2009
    ....
  20. ncbi Doctors breaching patient privacy: Orwell redux
    David J Handelsman
    ANZAC Research Institute, Concord Hospital, Sydney, NSW, Australia
    Med J Aust 194:403-4. 2011
    ..Legislative changes made without public discussion allow disclosure without patient consent...
  21. doi Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis
    Patrick Lim
    Andrology Laboratory, ANZAC Research Institute, Concord Hospital, Sydney, New South Wales 2139, Australia
    Endocrinology 150:4755-65. 2009
    ..Nongenomic or AR-DBD-independent pathways appear secondary or play no major independent role in SC function...
  22. doi Long-term effects of dihydrotestosterone treatment on prostate growth in healthy, middle-aged men without prostate disease: a randomized, placebo-controlled trial
    Amanda Idan
    Concord Hospital, ANZAC Research Institute, University of Sydney, Sydney, Australia
    Ann Intern Med 153:621-32. 2010
    ..Surgery is often required to control symptoms. It has been hypothesized that long-term administration of a nonamplifiable pure androgen might decrease prostate growth, thereby decreasing or delaying the need for surgical intervention...
  23. ncbi Oestradiol-induced spermatogenesis requires a functional androgen receptor
    Patrick Lim
    Andrology Laboratory, ANZAC Research Institute, Concord Hospital and University of Sydney, Australia
    Reprod Fertil Dev 20:861-70. 2008
    ..We propose that this paradoxical E2 spermatogenic response is explained by predominantly extratesticular E2 actions, increasing FSH to combine with residual androgen activity in hpg testes to stimulate pre- to post-meiotic development...
  24. doi Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen receptor inactivation
    Ulla Simanainen
    Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Am J Physiol Endocrinol Metab 296:E1335-43. 2009
    ....
  25. pmc The association of alanine transaminase with aging, frailty, and mortality
    David G Le Couteur
    Centre for Education and Research on Ageing, Concord RG Hospital, University of Sydney, Hospital Road, Concord, NSW 2139, Australia
    J Gerontol A Biol Sci Med Sci 65:712-7. 2010
    ..Low ALT activity is a predictor of reduced survival; however, this seems to be mediated by its association with frailty and increasing age. ALT has potential value as a novel biomarker of aging...
  26. ncbi Complete Sertoli cell proliferation induced by follicle-stimulating hormone (FSH) independently of luteinizing hormone activity: evidence from genetic models of isolated FSH action
    Charles M Allan
    Andrology Laboratory, ANZAC Research Institute, Concord Hospital, Sydney, Australia
    Endocrinology 145:1587-93. 2004
    ....
  27. doi Ethnicity and falls in older men: low rate of falls in Italian-born men in Australia
    Fiona F Stanaway
    Sydney School of Public Health, University of Sydney, Edward Ford Building A27, Sydney, New South Wales 2006, Australia
    Age Ageing 40:595-601. 2011
    ..past research suggests that fall rates in older persons may differ by ethnicity. The aim of this study was to compare the incidence of falls between older male Italian-born immigrants and their Australian-born counterparts...
  28. doi Longitudinal and cross-sectional relationships of circulating reproductive hormone levels to self-rated health and health-related quality of life in community-dwelling older men
    Benjumin Hsu
    School of Public Health B H, R G C, University of Sydney, New South Wales 2006, Australia Centre of Education and Research on Ageing B H, R G C, F M B, V N, D G L C, L M W, and ANZAC Research Institute R G C, D G L C, M J S, D J H, University of Sydney and Concord Hospital, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 99:1638-47. 2014
    ..Self-rated health and health-related quality of life are inversely associated with increased morbidity and mortality; however, the temporal relationship with reproductive hormones is poorly understood...
  29. ncbi Luteinizing hormone receptor-mediated effects on initiation of spermatogenesis in gonadotropin-deficient (hpg) mice are replicated by testosterone
    Jennifer A Spaliviero
    Andrology Laboratory, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, NSW 2139, Australia
    Biol Reprod 70:32-8. 2004
    ....
  30. ncbi Maintenance of spermatogenesis by the activated human (Asp567Gly) FSH receptor during testicular regression due to hormonal withdrawal
    Charles M Allan
    Andrology Laboratory, University of Sydney, ANZAC Research Institute, Concord Hospital, Sydney, New South Wales 2139, Australia
    Biol Reprod 74:938-44. 2006
    ....
  31. doi Within-subject variability and analytic imprecision of insulinlike growth factor axis and collagen markers: implications for clinical diagnosis and doping tests
    Tuan V Nguyen
    Garvan Institute of Medical Research and Department of Endocrinology, Sydney, Australia
    Clin Chem 54:1268-76. 2008
    ..We sought to determine short-term within-subject variability of these markers in a large cohort of healthy individuals...
  32. ncbi Prevalence and treatment of osteoporosis in older Australian men: findings from the CHAMP study
    Kerrin Bleicher
    University of Sydney, Sydney, NSW, Australia
    Med J Aust 193:387-91. 2010
    ..To determine the proportion of older Australian men who meet the Pharmaceutical Benefits Scheme (PBS) criteria for osteoporosis treatment and are receiving effective treatment...
  33. doi In vivo actions of the Sertoli cell glucocorticoid receptor
    Rasmani Hazra
    ANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, New South Wales 2139, Australia
    Endocrinology 155:1120-30. 2014
    ....
  34. doi Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project
    Vasant Hirani
    Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    J Am Geriatr Soc 62:417-25. 2014
    ....
  35. doi Sertoli cell androgen receptor expression regulates temporal fetal and adult Leydig cell differentiation, function, and population size
    Rasmani Hazra
    ANZAC Research Institute, Concord Hospital, Sydney, New South Wales 2139, Australia
    Endocrinology 154:3410-22. 2013
    ..Our unique gain-of-function TgSCAR model has revealed that SCAR activity controls temporal LC differentiation, steroidogenic function, and population size. ..
  36. doi Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes
    Danijela Gnjidic
    Department of Clinical Pharmacology, 11C Main Building, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    J Clin Epidemiol 65:989-95. 2012
    ..This study aimed to determine an optimal discriminating number of concomitant medications associated with geriatric syndromes, functional outcomes, and mortality in community-dwelling older men...
  37. doi Predicting participation restriction in community-dwelling older men: the Concord Health and Ageing in Men Project
    Nicola Fairhall
    Musculoskeletal Division, The George Institute for Global Health, PO Box M201 Missenden Road, Sydney, NSW 2050, Australia
    Age Ageing 43:31-7. 2014
    ..Our objective was to describe changes in participation in older men over a 2-year period and to identify baseline variables associated with participation and change in participation over the 2-year period...
  38. doi Characterizing the neuroendocrine and ovarian defects of androgen receptor-knockout female mice
    Xiaobing B Cheng
    ANZAC Research Institute, Andrology Laboratory, Concord Hospital, University of Sydney, New South Wales, Australia
    Am J Physiol Endocrinol Metab 305:E717-26. 2013
    ..These findings reveal that the AR has a functional role in neuroendocrine regulation and timing of the ovulatory LH surge as well as antral/preovulatory follicle development...
  39. doi Randomized cross-over clinical trial of injectable vs. implantable depot testosterone for maintenance of testosterone replacement therapy in androgen deficient men
    Carolyn Fennell
    Andrology Department, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Clin Endocrinol (Oxf) 73:102-9. 2010
    ..This study compared directly the two long-acting depot T products, subdermal T implants (TI) and injectable T undecanoate (TU) for maintenance of TRT...
  40. pmc Estradiol induction of spermatogenesis is mediated via an estrogen receptor-{alpha} mechanism involving neuroendocrine activation of follicle-stimulating hormone secretion
    Charles M Allan
    ANZAC Research Institute, Sydney, New South Wales 2139, Australia
    Endocrinology 151:2800-10. 2010
    ..We conclude that E2-induced spermatogenesis in hpg mice involves an ERalpha-dependent neuroendocrine mechanism increasing blood FSH and Sertoli cell function...
  41. pmc Follicle-stimulating hormone increases bone mass in female mice
    Charles M Allan
    ANZAC Research Institute, University of Sydney, Concord Hospital, NSW 2139, Australia
    Proc Natl Acad Sci U S A 107:22629-34. 2010
    ....
  42. doi Associations between frailty and serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations in older Australian men: the Concord Health and Ageing in Men Project
    Vasant Hirani
    Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, NSW 2139, Australia
    J Gerontol A Biol Sci Med Sci 68:1112-21. 2013
    ..The aim of this study was to examine the associations between serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels and frailty and components of frailty in older Australian men...
  43. doi Temporal role of Sertoli cell androgen receptor expression in spermatogenic development
    Rasmani Hazra
    ANZAC Research Institute, Concord Hospital, Sydney, New South Wales 2139, Australia
    Mol Endocrinol 27:12-24. 2013
    ....
  44. doi The role of fat and lean mass in bone loss in older men: findings from the CHAMP study
    Kerrin Bleicher
    University of Sydney, Sydney, Australia Centre for Education and Research on Ageing CHAMP Project, Concord Hospital, NSW, Australia
    Bone 49:1299-305. 2011
    ..The aim of this longitudinal analysis was to clarify the relationship between hip BMD, hip BMC and whole body BMC with changes in fat and lean tissue mass in older men...
  45. ncbi Androgen receptor gene expression in leucocytes is hormonally regulated: implications for gender differences in disease pathogenesis
    Mark A Sader
    Department of Cardiology, Royal Prince Alfred Hospital, NSW, Australia
    Clin Endocrinol (Oxf) 62:56-63. 2005
    ..We now investigate whether the gender difference in AR expression is due to genetic or hormonal regulation...
  46. doi Severe subfertility in mice with androgen receptor inactivation in sex accessory organs but not in testis
    Ulla Simanainen
    ANZAC Research Institute, Sydney, New South Wales 2139, Australia
    Endocrinology 149:3330-8. 2008
    ....
  47. doi Transgenic mutant D567G but not wild-type human FSH receptor overexpression provides FSH-independent and promiscuous glycoprotein hormone Sertoli cell signaling
    Charles M Allan
    ANZAC Research Institute, Concord Hospital, Sydney NSW 2139, Australia
    Am J Physiol Endocrinol Metab 296:E1022-8. 2009
    ....
  48. pmc Estimation of lean body weight in older community-dwelling men
    Sarah J Mitchell
    Sydney Medical School, University of Sydney, Sydney, NSW, Australia
    Br J Clin Pharmacol 69:118-27. 2010
    ..Further studies to determine whether the LBW equation is a clinically useful substitute for weight when determining drug dose in older people appear warranted...
  49. doi Back pain in older male Italian-born immigrants in Australia: the importance of socioeconomic factors
    Fiona F Stanaway
    Sydney School of Public Health, University of Sydney, NSW 2006, Australia
    Eur J Pain 15:70-6. 2011
    ..Multivariate analyses showed that differences in pain characteristics and effects between the two groups of men were explained by socioeconomic factors such as years of education and occupation history...
  50. doi Serum uric acid is associated with bone health in older men: a cross-sectional population-based study
    Iraj Nabipour
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia
    J Bone Miner Res 26:955-64. 2011
    ..51, 95% CI 0.29-0.89, p = .018) fractures. In conclusion, higher serum UA levels are associated with higher BMD at all skeletal sites and with a lower prevalence of vertebral and nonvertebral fractures in older men...
  51. doi Evidence for increased tissue androgen sensitivity in neurturin knockout mice
    Ulla Simanainen
    ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Endocrinol 218:151-63. 2013
    ....
  52. doi Anterior prostate epithelial AR inactivation modifies estrogen receptor expression and increases estrogen sensitivity
    Ulla Simanainen
    ANZAC Research Institute, University of Sydney, NSW, Australia
    Am J Physiol Endocrinol Metab 301:E727-35. 2011
    ....
  53. ncbi Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone
    Miriam Haywood
    Andrology Laboratory, ANZAC Research Institute, Concord Hospital, Concord, New South Wales 2139, Australia
    Endocrinology 144:509-17. 2003
    ....
  54. ncbi Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-kappaB-dependent pathway
    Alison K Death
    Discipline of Medicine, University of Sydney, New South Wales, Australia
    Endocrinology 145:1889-97. 2004
    ....
  55. ncbi Molecular cloning and characterization of a novel androgen repressible gene expressed in the prostate epithelium
    Jaskirat Singh
    Department of Medicine and Sydney Cancer Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW 2006, Australia
    Gene 348:55-63. 2005
    ..Cloning and characterization of ADMP has made it feasible to determine its prospective role in the absence of androgens in prostate cancer...
  56. ncbi An activated human follicle-stimulating hormone (FSH) receptor stimulates FSH-like activity in gonadotropin-deficient transgenic mice
    Miriam Haywood
    Andrology Laboratory, ANZAC Research Institute, Sydney, New South Wales 2139, Australia
    Mol Endocrinol 16:2582-91. 2002
    ..This novel transgenic paradigm provides a unique approach to investigate the in vivo actions of mutated activating gonadotropin receptors...
  57. doi Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate
    Bin Zhao
    Andrology, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Prostate 74:1068-78. 2014
    ..Glucocorticoids are used as a last resort treatment for prostate cancer but the cell-specific glucocorticoid receptor (GR) mediated actions and the role of endogenous glucocorticoids in prostate are not understood...
  58. doi Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study
    Gideon Sartorius
    Andrology Department, Concord Hospital, Clayton, Vic, Australia
    Clin Endocrinol (Oxf) 77:755-63. 2012
    ..To determine serum concentrations, intra-individual variability and impact of age-related co-morbidities on serum testosterone (T), dihydrotestosterone (DHT), estradiol (E(2)) and estrone (E(1)) in older men...
  59. doi Androgen resistance in female mice increases susceptibility to DMBA-induced mammary tumors
    Ulla Simanainen
    Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia
    Horm Cancer 3:113-24. 2012
    ..These results demonstrate that AR inactivation accelerates mammary carcinogenesis in female mice exposed to the chemical carcinogen DMBA regardless of mouse genetic background but require prior exposure to endogenous ovarian hormones...
  60. pmc How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over
    Fiona F Stanaway
    Sydney School of Public Health, University of Sydney, Sydney, Australia
    BMJ 343:d7679. 2011
    ..To determine the speed at which the Grim Reaper (or Death) walks...
  61. ncbi Gonadotropin control of inhibin secretion and the relationship to follicle type and number in the hpg mouse
    Yuan Wang
    Department of Reproductive Medicine, Westmead Hospital, New South Wales, Australia
    Biol Reprod 73:610-8. 2005
    ..The observed effects of gonadotropins on inhibin A and B secretion may be explained by corresponding gonadotropin effects on follicle development...
  62. ncbi Rising follicle-stimulating hormone levels with age accelerate female reproductive failure
    Kirsten J McTavish
    ANZAC Research Institute, University of Sydney, Concord Hospital, New South Wales, 2139 Australia
    Endocrinology 148:4432-9. 2007
    ....
  63. ncbi Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 92:3599-603. 2007
    ..Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time...
  64. pmc Multiple, but not traditional risk factors predict mortality in older people: the Concord Health and Ageing in Men Project
    Vasant Hirani
    Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, Hospital Road, Concord, NSW, Sydney, 2137, Australia
    Age (Dordr) 36:9732. 2014
    ....
  65. doi Targeted loss of androgen receptor signaling in murine granulosa cells of preantral and antral follicles causes female subfertility
    Kirsty A Walters
    ANZAC Research Institute, Department of Andrology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia
    Biol Reprod 87:151. 2012
    ....
  66. pmc Mild cognitive impairment predicts institutionalization among older men: a population-based cohort study
    Danijela Gnjidic
    Department of Clinical Pharmacology, Royal North Shore Hospital, Sydney, New South Wales, Australia
    PLoS ONE 7:e46061. 2012
    ..There is a lack of evidence on the contribution of mild cognitive impairment (MCI) to institutionalization in older adults. This study aimed to evaluate a range of risk factors including MCI of institutionalization in older men...
  67. pmc Length of the human androgen receptor glutamine tract determines androgen sensitivity in vivo
    Ulla Simanainen
    Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia
    Mol Cell Endocrinol 342:81-6. 2011
    ..In this manner, AR Q-tract length variation may influence numerous aspects of male health, from virilization to fertility, as well as androgen-dependent diseases, such as prostate cancer...
  68. ncbi Contraceptive efficacy of a depot progestin and androgen combination in men
    Leo Turner
    Department of Andrology, Concord Hospital, and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 88:4659-67. 2003
    ..Further studies of purpose-developed products are required to extend the overall safety and efficacy experience with depot androgen/progestin combinations, the most promising approach to hormonal male contraception...
  69. ncbi Rates of suppression and recovery of human sperm output in testosterone-based hormonal contraceptive regimens
    Lam P Ly
    Departments of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney NSW 2139, Australia
    Hum Reprod 20:1733-40. 2005
    ....
  70. ncbi Endocrine regulation of bone turnover in men
    Christian Meier
    Bone Research Program, ANZAC Research Institute, University of Sydney, Concord, New South Wales, Australia
    Clin Endocrinol (Oxf) 63:603-16. 2005
  71. doi Long-term corticosterone treatment induced lobe-specific pathology in mouse prostate
    Ulla Simanainen
    Department of Andrology, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Prostate 71:289-97. 2011
    ..Glucocorticoids influence prostate development and pathology, yet the underlying mechanisms including possible direct glucocorticoid effect on the prostate are not well characterized...
  72. ncbi Do reproductive hormones modify insulin sensitivity and metabolism in older men? A randomized, placebo-controlled clinical trial of recombinant human chorionic gonadotropin
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, Concord, New South Wales 2139, Australia
    Eur J Endocrinol 148:55-66. 2003
    ....
  73. ncbi The short-term effects of high-dose testosterone on sleep, breathing, and function in older men
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute and Concord Hospital, University of Sydney, Sydney, 2139 Australia
    J Clin Endocrinol Metab 88:3605-13. 2003
    ..These changes did not appear to be due to upper airway narrowing. Further study of longer-term lower-dose androgen therapy on sleep and breathing is needed to evaluate its safety in older men...
  74. ncbi Dehydroepiandrosterone, an adrenal androgen, increases human foam cell formation: a potentially pro-atherogenic effect
    Martin K C Ng
    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
    J Am Coll Cardiol 42:1967-74. 2003
    ..We studied the effects of dehydroepiandrosterone (DHEA), an abundant adrenal androgen on two key early events of atherogenenis: 1) human monocyte adhesion to vascular endothelium, and 2) human foam cell formation...
  75. ncbi Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function
    Ulla Simanainen
    ANZAC Research Institute, University of Sydney, New South Wales 2139, Australia
    Endocrinology 148:2264-72. 2007
    ....
  76. ncbi Depressive symptoms in older male Italian immigrants in Australia: the Concord Health and Ageing in Men Project
    Fiona F Stanaway
    School of Public Health, University of Sydney, Sydney, NSW
    Med J Aust 192:158-62. 2010
    ..To describe the prevalence of depressive symptoms in older male Italian-born Australian immigrants...
  77. doi Prostate epithelial AR inactivation leads to increased intraprostatic androgen synthesis
    Keely M McNamara
    Andrology, ANZAC Research Institute, University of Sydney, Sydney, Australia
    Prostate 73:316-27. 2013
    ..Regulation of steroid synthesis within the prostate is not well understood. In this study, we examined androgen synthesis and metabolism in the mouse prostate...
  78. doi Rodent models for human polycystic ovary syndrome
    Kirsty A Walters
    Andrology Laboratory, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia
    Biol Reprod 86:149, 1-12. 2012
    ..This review aimed to evaluate the rodent models reported to identify the advantages and disadvantages of the distinct rodent models used to investigate this complex endocrine disorder...
  79. ncbi A double-blind, placebo-controlled, randomized clinical trial of recombinant human chorionic gonadotropin on muscle strength and physical function and activity in older men with partial age-related androgen deficiency
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Concord NSW 2139, Australia
    J Clin Endocrinol Metab 87:3125-35. 2002
    ..We conclude that 3 months of treatment with twice weekly r-hCG demonstrates sustained androgenic effects on hormones and muscle mass but has no effect on muscle strength or physical functioning...
  80. ncbi Adequacy of androgen replacement influences bone density response to testosterone in androgen-deficient men
    Ashraf Aminorroaya
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    Eur J Endocrinol 152:881-6. 2005
    ..Although low bone mineral density (BMD) in AD men is improved by testosterone replacement, the responses vary between individuals but the determinants of this variability are not well defined...
  81. ncbi Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice
    Amanda J Notini
    Department of Medicine, The University of Melbourne, Heidelberg, Victoria, and ANZAC Research Institute, Concord Hospital, Sydney, New South Wales, Australia
    J Bone Miner Res 22:347-56. 2007
    ..These mice had decreased trabecular bone volume associated with a decrease in trabecular number, suggesting that androgens may act directly on osteoblasts to maintain trabecular bone...
  82. doi Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets
    Flora F Ip
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    Eur J Endocrinol 162:385-90. 2010
    ..We, therefore, sought to define the prevalence, predictors, and proximate basis (role of erythropoietin) for polycythemia (hematocrit >0.50) in hypogonadal men receiving testosterone implants long term...
  83. doi Accuracy of calculated free testosterone formulae in men
    Lam P Ly
    Andrology Department, Concord Hospital, Sydney, NSW 2139, Australia
    Clin Endocrinol (Oxf) 73:382-8. 2010
    ..We provide a large-scale evaluation of the predictive accuracy for different FT formulae compared with laboratory ED measurement and an analysis of clinical factors that may influence accuracy...
  84. ncbi Prostate-specific antigen levels in men aged 70 years and over: findings from the CHAMP study
    Melisa J Litchfield
    Centre for Education and Research on Ageing, Concord Hospital and University of Sydney, Sydney, NSW
    Med J Aust 196:395-8. 2012
    ..To describe values of serum prostate-specific antigen (PSA) in older men without diagnosed prostate cancer, categorised by age and country of birth, and to describe self-reported prostate cancer screening...
  85. ncbi Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment
    Bronwyn A L Crawford
    Department of Endocrinology, ANZAC Research Institute, Royal Prince Alfred Hospital and University of Sydney, Sydney, New South Wales, Australia
    J Clin Endocrinol Metab 88:3167-76. 2003
    ..001). These results suggest that androgen therapy may have a role in ameliorating adverse effects of glucocorticoid therapy such as muscle and bone loss and aromatization is necessary for androgen action on bone but not on muscle...
  86. ncbi Tetrahydrogestrinone is a potent androgen and progestin
    Alison K Death
    Heart Research Institute, Camperdown, Sydney, New South Wales 2050, Australia
    J Clin Endocrinol Metab 89:2498-500. 2004
    ..It has no estrogenic activity and no antagonism for any of the three steroid receptor classes...
  87. ncbi Recombinant human chorionic gonadotropin but not dihydrotestosterone alone stimulates osteoblastic collagen synthesis in older men with partial age-related androgen deficiency
    Christian Meier
    Bone Research Program, ANZAC Research Institute, University of Sydney, Concord, NSW 2139, Australia
    J Clin Endocrinol Metab 89:3033-41. 2004
    ..If androgen supplementation is required for aging men, aromatizable androgens with sufficient endogenous estrogenic activity may have the most beneficial effects on bone...
  88. doi Pharmacodynamics of growth hormone abuse biomarkers and the influence of gender and testosterone: a randomized double-blind placebo-controlled study in young recreational athletes
    Anne E Nelson
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst 2010, Sydney, NSW, Australia
    J Clin Endocrinol Metab 93:2213-22. 2008
    ..IGF axis proteins and collagen peptides are promising markers of GH abuse...
  89. pmc Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate
    Gideon Sartorius
    Andrology Department, Concord Hospital and ANZAC Research Institute, Sydney, NSW, Australia
    Asian J Androl 12:227-33. 2010
    ..Deep IM gluteal injection of depot TU in 4-mL castor oil is well tolerated and post-injection pain is influenced by earlier painful injection experience, as well as age and obesity...
  90. ncbi A novel transgenic model to characterize the specific effects of follicle-stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions
    C M Allan
    ANZAC Research Institute and Andrology Laboratory, Department of Medicine, University of Sydney, New South Wales 2006, Australia
    Endocrinology 142:2213-20. 2001
    ..Thus, these findings show that the transgenic FSHxhpg mouse provides a unique model for detailed investigations of the definitive in vivo actions of FSH alone...
  91. doi Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 94:801-8. 2009
    ..Understanding the predictors of response would inform clinical practice but requires multivariate analyses in sufficiently large clinical cohorts that are suitably detailed and frequently assessed...
  92. ncbi Predicting pregnancy and spermatogenesis by survival analysis during gonadotrophin treatment of gonadotrophin-deficient infertile men
    Peter Y Liu
    Department of Andrology and ANZAC Research Institute, Concord Hospital, Sydney NSW 2139, Australia
    Hum Reprod 17:625-33. 2002
    ..Predictors of fertility or spermatogenesis during gonadotrophin therapy of gonadotrophin-deficient men remain poorly defined...
  93. ncbi Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice
    J Singh
    Department of Obstetrics and Gynecology, University of Sydney, New South Wales, Australia
    Endocrinology 136:5311-21. 1995
    ..The hpg mouse model is a useful new paradigm to study the molecular basis of the hormonal induction of spermatogenesis...
  94. ncbi Follicle-stimulating hormone increases primordial follicle reserve in mature female hypogonadal mice
    C M Allan
    Andrology Laboratory, ANZAC Research Institute, University of Sydney, Concord Hospital, New South Wales 2139, Australia
    J Endocrinol 188:549-57. 2006
    ..Therefore, the tg-FSH hpg ovary presents a novel paradigm to evaluate specific gonadotrophin effects on follicle reserve and recruitment...
  95. ncbi The present and future state of hormonal treatment for male infertility
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, New South Wales, Australia
    Hum Reprod Update 9:9-23. 2003
    ..How such novel hormonal methods will develop in conjunction with improved ICSI/IVF or cloning technologies, and the potential role of adjunctive hormonal therapy remains to be clarified...
  96. ncbi Neonatal administration of FSH increases Sertoli cell numbers and spermatogenesis in gonadotropin-deficient (hpg) mice
    J Singh
    Department of Obstetrics and Gynaecology, Royal Prince Alfred Hospita, University of Sydney, New South Wales, Australia
    J Endocrinol 151:37-48. 1996
    ....
  97. ncbi Effects of androgen deficiency and replacement on prostate zonal volumes
    B Jin
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Clin Endocrinol (Oxf) 54:437-45. 2001
    ....
  98. ncbi Influence of implantation site and track geometry on the extrusion rate and pharmacology of testosterone implants
    S Kelleher
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, Australia
    Clin Endocrinol (Oxf) 55:531-6. 2001
    ..Neither implantation site, nor track geometry influenced either other adverse effects or the pharmacokinetics or pharmacodynamics of testosterone pellet implants...
  99. ncbi Androgen actions and the ovary
    K A Walters
    Andrology Laboratory, ANZAC Research Institute, Concord Hospital, University of Sydney, New South Wales 2139, Australia
    Biol Reprod 78:380-9. 2008
    ....
  100. ncbi Physiological testosterone replacement and arterial endothelial function in men
    Mark A Sader
    Department of Cardiology, Royal Prince Alfred Hospital, and Department of Medicine, The University of Sydney, Sydney, Australia
    Clin Endocrinol (Oxf) 59:62-7. 2003
    ..We therefore aimed to study arterial function in hypogonadal men receiving long-term physiological androgen replacement therapy, at trough and peak testosterone levels...
  101. ncbi Transgenic models for exploring gonadotropin biology in the male
    Charles M Allan
    ANZAC Research Institute, University of Sydney, Australia
    Endocrine 26:235-39. 2005
    ..This article will review the strategies to overcome these intimate connections and discuss key findings from trans-genic models developed to study gonadotropin actions in the male...