- Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRIFu Hua Wang
AstraZeneca Research and Development, Innovative Medicines, SE 15185 Sodertalje, Sweden
Eur J Neurosci 36:3165-72. 2012..Chronic treatment in vivo with a gamma-secretase inhibitor, MRK-560, significantly reduces soluble and insoluble forms of Aβ, and fully reverses the axonal transport dysfunction...
- Kv1.1 null mice have enlarged hippocampus and ventral cortexAnn Sophie Persson
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
BMC Neurosci 8:10. 2007..1 are known to cause episodic ataxia type 1 and temporal lobe epilepsy. Mice that express a malfunctional, truncated Kv1.1 (BALB/cByJ-Kv1.1mceph/mceph) show a markedly enlarged hippocampus and ventral cortex in adulthood...