Genomes and Genes
G M Kasof
Affiliation: AstraZeneca R and D
- Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaBG M Kasof
Department of Enabling Science and Technology, AstraZeneca Pharmaceuticals, 3 Biotech Park, One Innovation Drive, Worcester, Massachusetts, MA 01605, USA
Oncogene 20:7965-75. 2001..These results demonstrate that TNF-alpha signaling induces the expression of a member of its own receptor family through activation of NF-kappaB...
- The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondriaG M Kasof
AstraZeneca Pharmaceuticals, Enabling Science and Technology Department, 1800 Concord Pike, Wilmington, DE 19803, USA
FEBS Lett 473:285-91. 2000..RIP3 was localized by immunofluorescence to the mitochondrion and may play a key role in the mitochondrial disruptions often associated with apoptosis...
- Livin, a novel inhibitor of apoptosis protein family memberG M Kasof
AstraZeneca Pharmaceuticals, Enabling Sciences and Technology, Wilmington, Delaware 19803, USA
J Biol Chem 276:3238-46. 2001..This was associated with an increase in DNA fragmentation and in DEVD-like caspase activity. Thus, disruption of Livin may provide a strategy to induce apoptosis in certain cancer cells...
- Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteinsG M Kasof
Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
Mol Cell Biol 19:4390-404. 1999..Thus, btf may represent a novel tumor suppressor gene residing in a unique pathway by which the Bcl-2 family can regulate apoptosis...