Elena Arystarkhova

Summary

Publications

  1. ncbi request reprint Splice variants of the gamma subunit (FXYD2) and their significance in regulation of the Na, K-ATPase in kidney
    Elena Arystarkhova
    Laboratory of Membrane Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Bioenerg Biomembr 37:381-6. 2005
  2. ncbi request reprint Multiplicity of expression of FXYD proteins in mammalian cells: dynamic exchange of phospholemman and gamma-subunit in response to stress
    Elena Arystarkhova
    Laboratory of Membrane Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Cell Physiol 292:C1179-91. 2007
  3. ncbi request reprint Distribution and oligomeric association of splice forms of Na(+)-K(+)-ATPase regulatory gamma-subunit in rat kidney
    Elena Arystarkhova
    Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Am J Physiol Renal Physiol 282:F393-407. 2002
  4. ncbi request reprint FXYD proteins as regulators of the Na,K-ATPase in the kidney
    Kathleen J Sweadner
    Neuroscience Center, Massachusetts General Hospital, Charlestown 02129, USA
    Ann N Y Acad Sci 986:382-7. 2003
  5. ncbi request reprint Gamma structural variants differentially regulate Na,K-ATPase properties
    Elena Arystarkhova
    Neuroscience Center, Massachusetts General Hospital, Charlestown 02129, USA
    Ann N Y Acad Sci 986:416-9. 2003
  6. ncbi request reprint Stress-induced expression of the gamma subunit (FXYD2) modulates Na,K-ATPase activity and cell growth
    Randall K Wetzel
    Laboratory of Membrane Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 279:41750-7. 2004
  7. pmc Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNA
    Kathleen J Sweadner
    Laboratory of Membrane Biology, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:18290-300. 2011
  8. pmc Hyperplasia of pancreatic beta cells and improved glucose tolerance in mice deficient in the FXYD2 subunit of Na,K-ATPase
    Elena Arystarkhova
    Laboratory Membrane Biology, Massachusetts General Hospital, Boston, Massachusetts 2114, USA
    J Biol Chem 288:7077-85. 2013
  9. pmc A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1
    Yi Bessie Liu
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, United States
    elife 4:. 2015
  10. doi request reprint Functional Studies of Na(+),K(+)-ATPase Using Transfected Cell Cultures
    Elena Arystarkhova
    Laboratory of Membrane Biology, Massachusetts General Hospital, Edwards 410, 55 Fruit St, Boston, MA, 02114, USA
    Methods Mol Biol 1377:321-32. 2016

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Splice variants of the gamma subunit (FXYD2) and their significance in regulation of the Na, K-ATPase in kidney
    Elena Arystarkhova
    Laboratory of Membrane Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Bioenerg Biomembr 37:381-6. 2005
    ..The focus is on splice variants of gamma, their structural similarity and yet distinct effects conferred to Na, K-ATPase...
  2. ncbi request reprint Multiplicity of expression of FXYD proteins in mammalian cells: dynamic exchange of phospholemman and gamma-subunit in response to stress
    Elena Arystarkhova
    Laboratory of Membrane Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Cell Physiol 292:C1179-91. 2007
    ..The data imply that FXYDs are obligatory rather than auxiliary components of Na-K-ATPase, and their interchangeability underlies responses of Na-K-ATPase to cellular stress...
  3. ncbi request reprint Distribution and oligomeric association of splice forms of Na(+)-K(+)-ATPase regulatory gamma-subunit in rat kidney
    Elena Arystarkhova
    Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Am J Physiol Renal Physiol 282:F393-407. 2002
    ..Because different mechanisms maintain and regulate Na(+) homeostasis in different nephron segments, the splice forms of the gamma-subunit may have evolved to control the renal Na(+) pump through pump properties, gene expression, or both...
  4. ncbi request reprint FXYD proteins as regulators of the Na,K-ATPase in the kidney
    Kathleen J Sweadner
    Neuroscience Center, Massachusetts General Hospital, Charlestown 02129, USA
    Ann N Y Acad Sci 986:382-7. 2003
    ..In contrast, alpha1, beta1, and gamma were found in adjacent macula densa. Phospholemman, alpha2, and beta2 are proposed to have distinct roles in regulating the sodium pump in structures involved in tubuloglomerular feedback...
  5. ncbi request reprint Gamma structural variants differentially regulate Na,K-ATPase properties
    Elena Arystarkhova
    Neuroscience Center, Massachusetts General Hospital, Charlestown 02129, USA
    Ann N Y Acad Sci 986:416-9. 2003
    ..The data imply an adaptive physiological mechanism of regulation of renal Na,K-ATPase through modulation of pump properties, gene expression, or both...
  6. ncbi request reprint Stress-induced expression of the gamma subunit (FXYD2) modulates Na,K-ATPase activity and cell growth
    Randall K Wetzel
    Laboratory of Membrane Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 279:41750-7. 2004
    ..Taken together, the data imply that induction of gammaa may have adaptive value by being a part of a general cellular response to genotoxic stress...
  7. pmc Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNA
    Kathleen J Sweadner
    Laboratory of Membrane Biology, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:18290-300. 2011
    ..The data confirm truncation of FXYD2b as a potential mechanism to regulate the amount of FXYD2 at the cell surface to control activity of Na,K-ATPase and cell growth...
  8. pmc Hyperplasia of pancreatic beta cells and improved glucose tolerance in mice deficient in the FXYD2 subunit of Na,K-ATPase
    Elena Arystarkhova
    Laboratory Membrane Biology, Massachusetts General Hospital, Boston, Massachusetts 2114, USA
    J Biol Chem 288:7077-85. 2013
    ..Thus we suggest that in pancreatic beta cells FXYD2 plays a role in Akt signaling pathways associated with cell growth and proliferation...
  9. pmc A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1
    Yi Bessie Liu
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, United States
    elife 4:. 2015
    ..The mouse is a new model for testing how dysfunction in the CNS causes specific abnormal movements and postures. ..
  10. doi request reprint Functional Studies of Na(+),K(+)-ATPase Using Transfected Cell Cultures
    Elena Arystarkhova
    Laboratory of Membrane Biology, Massachusetts General Hospital, Edwards 410, 55 Fruit St, Boston, MA, 02114, USA
    Methods Mol Biol 1377:321-32. 2016
    ..Moreover, expression of FXYD2 reduced cell growth. Here we describe the methodologies as well as potential pitfalls. ..
  11. ncbi request reprint Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit
    Elena Arystarkhova
    Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:10162-72. 2002
    ....