Michael Arthur

Summary

Publications

  1. pmc N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1
    Frank Murphy
    Liver Group, Division of Infection, Inflammation and Repair, Southampton University, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Comp Hepatol 3:S8. 2004
  2. ncbi request reprint Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis
    Frank R Murphy
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Hampshire SO16 6YD, United Kingdom
    J Biol Chem 277:11069-76. 2002
  3. ncbi request reprint Developing strategies for liver fibrosis treatment
    Frank Murphy
    Liver Research Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Expert Opin Investig Drugs 11:1575-85. 2002
  4. ncbi request reprint Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells
    Xiaoying Zhou
    Liver Research Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, United Kingdom
    J Biol Chem 279:23996-4006. 2004
  5. ncbi request reprint High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors
    Runping Gao
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Level D, South Academic Block, Southampton General Hospital, Tremona Road, Southampton, UK
    Liver 22:15-22. 2002

Collaborators

  • Hideaki Nagase
  • Junlong Zhang
  • John Iredale
  • Frank Murphy
  • Frank R Murphy
  • Xiaoying Zhou
  • R Christopher Benyon
  • Runping Gao
  • Julian Waung
  • Nitu Gehdu
  • Jane Collins
  • Derek Mann
  • Richard Ruddell
  • Christopher J McCormick
  • Mark P G Harris
  • Fiona Oakley
  • Razao Issa
  • Derek A Mann
  • Christopher Benyon
  • David E Smart
  • Shabna Ratnarajah

Detail Information

Publications5

  1. pmc N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1
    Frank Murphy
    Liver Group, Division of Infection, Inflammation and Repair, Southampton University, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Comp Hepatol 3:S8. 2004
    ..This is associated with reduced fragmentation of N-Cadherin. N-Cadherin may have an important role in supporting HSC survival while N-Cadherin cleavage may play a part in promoting HSC apoptosis in recovery from liver fibrosis...
  2. ncbi request reprint Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis
    Frank R Murphy
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Hampshire SO16 6YD, United Kingdom
    J Biol Chem 277:11069-76. 2002
    ..We conclude that TIMP-1 inhibits apoptosis of activated HSC via MMP inhibition...
  3. ncbi request reprint Developing strategies for liver fibrosis treatment
    Frank Murphy
    Liver Research Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Expert Opin Investig Drugs 11:1575-85. 2002
    ..The detailed understanding of hepatic stellate cell biology has allowed the rational design of novel antifibrotic therapies. This review describes for the general reader the novel emerging therapies for liver fibrosis...
  4. ncbi request reprint Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells
    Xiaoying Zhou
    Liver Research Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, United Kingdom
    J Biol Chem 279:23996-4006. 2004
    ....
  5. ncbi request reprint High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors
    Runping Gao
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Level D, South Academic Block, Southampton General Hospital, Tremona Road, Southampton, UK
    Liver 22:15-22. 2002
    ..The aim of this study was to determine if baculovirus vectors can infect and express target genes in rat and human HSC and to assess potential cytotoxic and modulatory effects of infection...