Mattia Albiero

Summary

Publications

  1. pmc The dipeptidyl peptidase-4 inhibitor saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients
    Nicol Poncina
    Venetian Institute of Molecular Medicine, University Hospital of Padova, Via Giustiniani, Padova 2, 35100, Italy
    Cardiovasc Diabetol 13:92. 2014
  2. ncbi Strategies for enhancing progenitor cell mobilization and function in diabetes
    Mattia Albiero
    Department of Medicine, Division of Metabolic Diseases, University of Padova, Venetian Institute of Molecular Medicine VIMM, Padova, Italy
    Curr Vasc Pharmacol 10:310-21. 2012
  3. doi Circulating smooth muscle progenitors and atherosclerosis
    Mattia Albiero
    Department of Clinicaland Experimental Medicine, University of Padova Medical School and Venetian Institute of Molecular Medicine VIMM, Padova 35129, Italy
    Trends Cardiovasc Med 20:133-40. 2010
  4. doi Myeloid calcifying cells promote atherosclerotic calcification via paracrine activity and allograft inflammatory factor-1 overexpression
    Mattia Albiero
    Venetian Institute of Molecular Medicine, Padova, Italy
    Basic Res Cardiol 108:368. 2013
  5. pmc Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery disease
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, 35128 Padova, Italy
    Exp Diabetes Res 2012:921685. 2012
  6. pmc Diabetes impairs stem cell and proangiogenic cell mobilization in humans
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Padova, Italy
    Diabetes Care 36:943-9. 2013
  7. pmc The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, School of Medicine, University of Padova, Padova, Italy
    Diabetes Care 33:1607-9. 2010
  8. doi Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Via Giustiniani, 2, 35100 Padua, Italy
    Basic Res Cardiol 108:313. 2013
  9. doi Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
    Circ Res 108:1112-21. 2011
  10. doi Bone Marrow Macrophages Contribute to Diabetic Stem Cell Mobilopathy by Producing Oncostatin M
    Mattia Albiero
    Department of Medicine, University of Padova, Padova, Italy Venetian Institute of Molecular Medicine, Padova, Italy
    Diabetes 64:2957-68. 2015

Collaborators

Detail Information

Publications26

  1. pmc The dipeptidyl peptidase-4 inhibitor saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients
    Nicol Poncina
    Venetian Institute of Molecular Medicine, University Hospital of Padova, Via Giustiniani, Padova 2, 35100, Italy
    Cardiovasc Diabetol 13:92. 2014
    ..DPP-4 inhibitors, a class of oral agents for T2D, might possess pleiotropic vasculoprotective activities. Herein, we tested whether DPP-4 inhibition with Saxagliptin affects the function of circulating PACs from T2D and healthy subjects...
  2. ncbi Strategies for enhancing progenitor cell mobilization and function in diabetes
    Mattia Albiero
    Department of Medicine, Division of Metabolic Diseases, University of Padova, Venetian Institute of Molecular Medicine VIMM, Padova, Italy
    Curr Vasc Pharmacol 10:310-21. 2012
    ..In this review we discuss the strategies to stimulate the mobilization of progenitors in diabetes and the protocols to improve their functions...
  3. doi Circulating smooth muscle progenitors and atherosclerosis
    Mattia Albiero
    Department of Clinicaland Experimental Medicine, University of Padova Medical School and Venetian Institute of Molecular Medicine VIMM, Padova 35129, Italy
    Trends Cardiovasc Med 20:133-40. 2010
    ..Furthermore, we examine the potential contribution of smooth muscle progenitors in the development/progression of atherosclerotic lesions...
  4. doi Myeloid calcifying cells promote atherosclerotic calcification via paracrine activity and allograft inflammatory factor-1 overexpression
    Mattia Albiero
    Venetian Institute of Molecular Medicine, Padova, Italy
    Basic Res Cardiol 108:368. 2013
    ..In conclusion, we show that murine OC(+)BAP(+) cells correspond to human MCCs and promote atherosclerotic calcification in ApoE(-/-) mice, through paracrine activity and modulation of resident cells by AIF-1 overexpression. ..
  5. pmc Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery disease
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, 35128 Padova, Italy
    Exp Diabetes Res 2012:921685. 2012
    ..In conclusion, circulating progenitor cells of diabetic patients show a phenotypic drift toward a pro-calcific phenotype that may be driven by inflammatory signals...
  6. pmc Diabetes impairs stem cell and proangiogenic cell mobilization in humans
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Padova, Italy
    Diabetes Care 36:943-9. 2013
    ..Herein, we sought to assay mobilization of stem and proangiogenic cells in subjects with and without DM...
  7. pmc The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, School of Medicine, University of Padova, Padova, Italy
    Diabetes Care 33:1607-9. 2010
    ..Because SDF-1alpha is a substrate of dipeptidyl-peptidase-4 (DPP-4), we investigated whether the DPP-4 inhibitor sitagliptin modulates EPC levels in type 2 diabetic patients...
  8. doi Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Via Giustiniani, 2, 35100 Padua, Italy
    Basic Res Cardiol 108:313. 2013
    ..In conclusion, the analysis of stem cell compartmentalization in humans led us to discover mechanisms of BM unresponsiveness in diabetes determined by tissue-specific DPP-4 dysregulation...
  9. doi Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
    Circ Res 108:1112-21. 2011
    ..Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in diabetes...
  10. doi Bone Marrow Macrophages Contribute to Diabetic Stem Cell Mobilopathy by Producing Oncostatin M
    Mattia Albiero
    Department of Medicine, University of Padova, Padova, Italy Venetian Institute of Molecular Medicine, Padova, Italy
    Diabetes 64:2957-68. 2015
    ..In conclusion, BMMΦ prevent SC mobilization by OSM secretion, and OSM antagonism is a strategy to restore BM function in diabetes, which can translate into protection mediated by BMSCs. ..
  11. doi Circulating myeloid calcifying cells have antiangiogenic activity via thrombospondin-1 overexpression
    Lisa Menegazzo
    2Department of Medicine, Division of Metabolic Diseases, University Hospital of Padova, Via Giustiniani 2, 35100 Padova, Italy
    FASEB J 27:4355-65. 2013
    ..The study highlights the successful identification and validation of a pathogenic pathway by a gold standard proteomic/transcriptomic analysis of blood cells...
  12. doi Rosuvastatin stimulates clonogenic potential and anti-inflammatory properties of endothelial progenitor cells
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Cell Biol Int 34:709-15. 2010
    ..In conclusion, we show that rosuvastatin had significant stimulatory effects on EPCs irrespective of the culture protocol. Rosuvastatin also induced anti-inflammatory polarization of monocytic EPCs...
  13. doi Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1
    Mattia Albiero
    Venetian Institute of Molecular Medicine, Padova, Italy
    Diabetes 63:1353-65. 2014
    ..CD62L KO partially rescued the defective stem/progenitor cell mobilization. In conclusion, autonomic neuropathy in the BM impairs stem cell mobilization in diabetes with dysregulation of the life-span regulators p66Shc and Sirt1. ..
  14. doi Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Italy
    Atherosclerosis 197:496-503. 2008
    ..We uncover the many traps hidden in the choice of the right protocol, and suggest the best solutions on the basis of evidence and background theories...
  15. pmc The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes 59:2306-14. 2010
    ..Genetic deletion of p66Shc prolongs life span and protects against oxidative stress. In the present study, we evaluated the role of p66Shc in an animal model of diabetic wound healing...
  16. doi Endothelial progenitor cells in diabetes mellitus
    Lisa Menegazzo
    Department of Medicine, University of Padova, Italy
    Biofactors 38:194-202. 2012
    ..In this review, EPC alterations will be examined in the context of macrovascular and microvascular complications of diabetes, highlighting their roles and functions in the progression of the disease...
  17. ncbi Pharmacologic targeting of endothelial progenitor cells
    Mattia Albiero
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Cardiovasc Hematol Disord Drug Targets 10:16-32. 2010
    ..An alternative strategy to partially overcome these limitations is to target EPCs with available drugs. In this review we will discuss how disparate pharmacological compounds have been used to improve EPCs number and functions...
  18. pmc Effects of androgens on endothelial progenitor cells in vitro and in vivo
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Clin Sci (Lond) 117:355-64. 2009
    ..In conclusion, our results collectively demonstrate that androgens exert no direct effects on endothelial progenitor cell biology in vitro and in vivo...
  19. doi Endothelial progenitor cells are reduced in acromegalic patients and can be restored by treatment with somatostatin analogs
    Gian Paolo Fadini
    Department of Medicine G P F, V d K, A A, Division of Metabolic Diseases, Laboratory of Experimental Diabetology G P F, M A, A A, Venetian Institute of Molecular Medicine, Department of Medicine F D, i A, C M, R V, P M, Internal Medicine 3, Center for the Study and Integrated Therapy of Obesity, Endocrine Metabolic Laboratory, and Department of Medicine, Immunology, and Hematology E B, C A, University of Padova, 35100 Padova, Italy
    J Clin Endocrinol Metab 99:E2549-56. 2014
    ..Acromegaly increases cardiovascular risk, possibly due to the high prevalence of classical risk factors. However, in vitro studies show a protective role of GH/IGF-1 on the endothelium...
  20. pmc Diabetes Limits Stem Cell Mobilization Following G-CSF but Not Plerixafor
    Gian Paolo Fadini
    Division of Metabolic Diseases, Department of Medicine, University of Padova, Padova, Italy Laboratory of Experimental Diabetology, Venetian Institute of Molecular Medicine, Padova, Italy
    Diabetes 64:2969-77. 2015
    ..This finding has major implications for the care of patients with diabetes undergoing stem cell mobilization and transplantation and for the vascular regenerative potential of bone marrow stem cells. ..
  21. doi The molecular signature of impaired diabetic wound healing identifies serpinB3 as a healing biomarker
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy
    Diabetologia 57:1947-56. 2014
    ..Chronic foot ulceration is a severe complication of diabetes, driving morbidity and mortality. The mechanisms underlying delaying wound healing in diabetes are incompletely understood and tools to identify such pathways are eagerly awaited...
  22. doi Circulating Progenitor Cell Count Predicts Microvascular Outcomes in Type 2 Diabetic Patients
    Mauro Rigato
    Division of Metabolic Diseases, Department of Medicine M R, C B, M A, A A, G P F, University of Padova, 35128 Padova, Italy and Venetian Institute of Molecular Medicine A A, G P F, 35128 Padova, Italy
    J Clin Endocrinol Metab 100:2666-72. 2015
    ..Diabetes reduces the levels of circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs), which promote vascular repair and are inversely correlated with cardiovascular risk...
  23. ncbi Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism
    Giulio Ceolotto
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2 35128 Padova, Italy
    Arterioscler Thromb Vasc Biol 27:2627-33. 2007
    ..In this study, we tested the hypothesis that rosiglitazone (RSG) is able to quench oxidative stress initiated by high glucose through prevention of NAD(P)H oxidase activation...
  24. pmc The peritoneum as a natural scaffold for vascular regeneration
    Stefano Bonvini
    Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy
    PLoS ONE 7:e33557. 2012
    ..The peritoneum has the same developmental origin as blood vessels, is highly reactive and poorly thrombogenic. We hypothesize that parietal peritoneum can sustain development and regeneration of new vessels...
  25. ncbi Circulating cellular players in vascular calcification
    Mattia Albiero
    Department of Medicine, University Hospital of Padova, Via Giustiniani, 2, 35100 Padova, Italy
    Curr Pharm Des 20:5889-96. 2014
    ..After an overview of the mechanism involved in vascular calcification, we herein discuss the potential role of different populations of circulating calcifying cells. ..
  26. ncbi Number and function of endothelial progenitor cells as a marker of severity for diabetic vasculopathy
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Italy
    Arterioscler Thromb Vasc Biol 26:2140-6. 2006
    ..This study aimed to establish whether number and function of EPCs correlate with PAD severity in type 2 diabetic patients...