Jonathan Afilalo

Summary

Publications

  1. doi request reprint Incremental value of the preoperative echocardiogram to predict mortality and major morbidity in coronary artery bypass surgery
    Jonathan Afilalo
    Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA
    Circulation 127:356-64. 2013
  2. doi request reprint Off-pump vs. on-pump coronary artery bypass surgery: an updated meta-analysis and meta-regression of randomized trials
    Jonathan Afilalo
    Division of Cardiology, Department of Medicine, SMBD Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
    Eur Heart J 33:1257-67. 2012
  3. doi request reprint Addition of frailty and disability to cardiac surgery risk scores identifies elderly patients at high risk of mortality or major morbidity
    Jonathan Afilalo
    Division of Cardiology, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Circ Cardiovasc Qual Outcomes 5:222-8. 2012
  4. doi request reprint Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery
    Jonathan Afilalo
    Division of Cardiology, Department of Medicine, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 56:1668-76. 2010
  5. doi request reprint Role of frailty in patients with cardiovascular disease
    Jonathan Afilalo
    Division of Cardiology, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Cardiol 103:1616-21. 2009
  6. doi request reprint Usefulness of right ventricular dysfunction to predict new-onset atrial fibrillation following coronary artery bypass grafting
    Avi Shimony
    Division of Cardiology, Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Am J Cardiol 113:913-8. 2014
  7. doi request reprint Aortic sclerosis is associated with mortality and major morbidity in patients undergoing coronary artery bypass surgery
    Aidan W Flynn
    Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, Harvard University, 55 Fruit Street, Boston, MA 02114, USA
    Heart 99:247-52. 2013
  8. doi request reprint Comparison of cancer risk associated with low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction in women versus men
    Patrick R Lawler
    Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada Division of Cardiology, Department of Medicine, Jewish General Hospital, Montreal, Quebec, Canada Division of Clinical Epidemiology, Department of Medicine, Jewish General Hospital, Montreal, Quebec, Canada
    Am J Cardiol 112:1545-50. 2013
  9. pmc A simple echocardiographic method to estimate pulmonary vascular resistance
    Alexander R Opotowsky
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Cardiol 112:873-82. 2013
  10. doi request reprint Geriatric congenital heart disease: burden of disease and predictors of mortality
    Jonathan Afilalo
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 58:1509-15. 2011

Collaborators

Detail Information

Publications39

  1. doi request reprint Incremental value of the preoperative echocardiogram to predict mortality and major morbidity in coronary artery bypass surgery
    Jonathan Afilalo
    Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA
    Circulation 127:356-64. 2013
    ..Although echocardiography is commonly performed before coronary artery bypass surgery, there has yet to be a study examining the incremental prognostic value of a complete echocardiogram...
  2. doi request reprint Off-pump vs. on-pump coronary artery bypass surgery: an updated meta-analysis and meta-regression of randomized trials
    Jonathan Afilalo
    Division of Cardiology, Department of Medicine, SMBD Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
    Eur Heart J 33:1257-67. 2012
    ..We sought to analyse the contemporary evidence for OPCAB vs. conventional coronary artery bypass (CCAB), incorporating recent larger trials, and adjusting for differences in trials using a technique known as meta-regression...
  3. doi request reprint Addition of frailty and disability to cardiac surgery risk scores identifies elderly patients at high risk of mortality or major morbidity
    Jonathan Afilalo
    Division of Cardiology, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Circ Cardiovasc Qual Outcomes 5:222-8. 2012
    ..73-0.76). Conclusions- Clinicians should use an integrative approach combining frailty, disability, and risk scores to better characterize elderly patients referred for cardiac surgery and identify those that are at increased risk...
  4. doi request reprint Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery
    Jonathan Afilalo
    Division of Cardiology, Department of Medicine, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 56:1668-76. 2010
    ..The purpose of this study was to test the value of gait speed, a clinical marker for frailty, to improve the prediction of mortality and major morbidity in elderly patients undergoing cardiac surgery...
  5. doi request reprint Role of frailty in patients with cardiovascular disease
    Jonathan Afilalo
    Division of Cardiology, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Cardiol 103:1616-21. 2009
    ..The role of frailty assessment in clinical practice may be to refine estimates of cardiovascular risk, which tend to be less accurate in the heterogenous elderly patient population...
  6. doi request reprint Usefulness of right ventricular dysfunction to predict new-onset atrial fibrillation following coronary artery bypass grafting
    Avi Shimony
    Division of Cardiology, Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Am J Cardiol 113:913-8. 2014
    ....
  7. doi request reprint Aortic sclerosis is associated with mortality and major morbidity in patients undergoing coronary artery bypass surgery
    Aidan W Flynn
    Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, Harvard University, 55 Fruit Street, Boston, MA 02114, USA
    Heart 99:247-52. 2013
    ..In this study, we aim to investigate the association between aortic sclerosis and mortality and major morbidity in patients with established coronary artery disease undergoing coronary artery bypass grafting (CABG)...
  8. doi request reprint Comparison of cancer risk associated with low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction in women versus men
    Patrick R Lawler
    Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada Division of Cardiology, Department of Medicine, Jewish General Hospital, Montreal, Quebec, Canada Division of Clinical Epidemiology, Department of Medicine, Jewish General Hospital, Montreal, Quebec, Canada
    Am J Cardiol 112:1545-50. 2013
    ..The extrapolated absolute risk from LDIR exposure would nonetheless be expected to be low...
  9. pmc A simple echocardiographic method to estimate pulmonary vascular resistance
    Alexander R Opotowsky
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Cardiol 112:873-82. 2013
    ....
  10. doi request reprint Geriatric congenital heart disease: burden of disease and predictors of mortality
    Jonathan Afilalo
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 58:1509-15. 2011
    ..The study sought to measure the prevalence, disease burden, and determinants of mortality in geriatric adults with congenital heart disease (ACHD)...
  11. doi request reprint Derivation and Validation of Prognosis-Based Age Cutoffs to Define Elderly in Cardiac Surgery
    Jonathan Afilalo
    From the Division of Cardiology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC, Canada J A, L G R Department of Mathematics, McGill University, Montreal, QC, Canada R S Center for Clinical Epidemiology, Jewish General Hospital, McGill University, Montreal, QC, Canada J A, R S Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA W J M Division of Cardiac Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA K R K Division of Cardiac Surgery, Department of Surgery, Jewish General Hospital, McGill University, Montreal, QC, Canada Y L, J F M and Department of Cardiovascular Medicine, Massachusetts General Hospital, Harvard University, Boston M H P
    Circ Cardiovasc Qual Outcomes 9:424-31. 2016
    ..We sought to characterize the relationship between age and adverse outcomes in patients undergoing cardiac surgery and to derive and validate prognosis-based age cutoffs...
  12. doi request reprint Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis
    Jonathan Afilalo
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Canada
    J Am Coll Cardiol 51:37-45. 2008
    ..This study was designed to determine whether statins reduce all-cause mortality in elderly patients with coronary heart disease...
  13. doi request reprint Exposure to low-dose ionizing radiation from cardiac imaging among patients with myocardial infarction
    Patrick R Lawler
    Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Cardiol 109:31-5. 2012
    ..However, the observed trend is toward increasing use of therapeutic procedures with proven mortality benefit undertaken earlier in the disease course and away from diagnostic procedures in the subsequent years after AMI...
  14. doi request reprint Psoas Muscle Area and Length of Stay in Older Adults Undergoing Cardiac Operations
    Jesse Zuckerman
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Ann Thorac Surg . 2016
    ..The objective of this study was to evaluate the association between CT muscle area and length of stay (LOS) after cardiac surgical procedures...
  15. pmc Leaflet area as a determinant of tricuspid regurgitation severity in patients with pulmonary hypertension
    Jonathan Afilalo
    From the Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Canada J A, D L, L G R Cardiac Ultrasound Laboratory, Division of Cardiology J G, P N and National Pulmonary Hypertension Service, Division of Cardiology J S R G, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom Pulmonary Hypertension and Thromboendarterectomy Program, Division of Pulmonary and Critical Care Medicine R N C and Cardiac Ultrasound Laboratory, Division of Cardiology J A, J B, L H, M D H, M H P, R A L, Massachusetts General Hospital, Harvard University, Boston
    Circ Cardiovasc Imaging 8:. 2015
    ..We hypothesized that tricuspid leaflet area (TLA) is increased in PH, and that the adequacy of this increase relative to right ventricular remodeling determines TR severity...
  16. pmc Risk Prediction in Aortic Valve Replacement: Incremental Value of the Preoperative Echocardiogram
    Timothy C Tan
    Massachusetts General Hospital, Harvard Medical School, Boston, MA T C T, A W F, P M, M C N, L M R, D M S, M H P, J A
    J Am Heart Assoc 4:e002129. 2015
    ..We sought to evaluate the incremental predictive value of a complete echocardiogram to identify high-risk surgical candidates before AVR...
  17. doi request reprint Therapeutic interventions for frail elderly patients: part II. Ongoing and unpublished randomized trials
    Melissa Bendayan
    Department of Physiology, McGill University, Montreal, Canada
    Prog Cardiovasc Dis 57:144-51. 2014
    ..Their respective study designs, populations, interventions, and planned outcomes are presented in this article. ..
  18. pmc Frailty assessment in the cardiovascular care of older adults
    Jonathan Afilalo
    Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada Electronic address
    J Am Coll Cardiol 63:747-62. 2014
    ..Ultimately, frailty should not be viewed as a reason to withhold care but rather as a means of delivering it in a more patient-centered fashion. ..
  19. doi request reprint Pulmonary arterial hypertension in the elderly-clinical characteristics and long-term survival
    Avi Shimony
    Center for Pulmonary Vascular Disease and Divisions of Cardiology and Respirology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada
    Lung 190:645-9. 2012
    ..We aimed to examine the features and prognostic factors of long-term survival in elderly (≥65 years) PAH patients...
  20. doi request reprint Alendronate affects calcium dynamics in cardiomyocytes in vitro
    Naomi Kemeny-Suss
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada H3A 2B2
    Vascul Pharmacol 51:350-8. 2009
    ....
  21. doi request reprint Prevalence and impact of coronary artery disease in patients with pulmonary arterial hypertension
    Avi Shimony
    Center for Pulmonary Vascular Disease, Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Am J Cardiol 108:460-4. 2011
    ..In conclusion, our study has demonstrated that CAD is common among patients with PAH. CAD prevalence increases with age, dyslipidemia, and hypertension, but we did not detect an independent prognostic effect of CAD on mortality...
  22. doi request reprint Psoas Muscle Area and All-Cause Mortality After Transcatheter Aortic Valve Replacement: The Montreal-Munich Study
    Samuel Mamane
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Can J Cardiol 32:177-82. 2016
    ..The objective of this study was to determine if PMA would be incrementally predictive of mortality and morbidity after TAVR...
  23. pmc Outcome Reporting in Cardiac Surgery Trials: Systematic Review and Critical Appraisal
    Michael Goldfarb
    Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada M G, J A
    J Am Heart Assoc 4:e002204. 2015
    ..The objective of this paper was to systematically review the literature to evaluate the current use and definition of perioperative outcomes reported in cardiac surgery trials...
  24. doi request reprint Effectiveness of renal denervation therapy for resistant hypertension: a systematic review and meta-analysis
    Mark I Davis
    Department of Internal Medicine, Jewish General Hospital, McGill University, Montreal, Canada
    J Am Coll Cardiol 62:231-41. 2013
    ..This study sought to determine the current effectiveness and safety of sympathetic renal denervation (RDN) for resistant hypertension...
  25. doi request reprint Predictors of vacuum-assisted closure failure of sternotomy wounds
    Perry Gdalevitch
    Department of Plastic and Reconstructive Surgery, University of Montreal, Montreal, QC, Canada
    J Plast Reconstr Aesthet Surg 63:180-3. 2010
    ..The purpose of this study is to evaluate clinical predictors of VAC therapy failure in order to predict which patients would benefit from this approach...
  26. doi request reprint Gait Speed and Operative Mortality in Older Adults Following Cardiac Surgery
    Jonathan Afilalo
    Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    JAMA Cardiol 1:314-21. 2016
    ..Existing risk models may be improved by integrating a measure of frailty, such as 5-m gait speed, to better capture the heterogeneity of the older adult population...
  27. doi request reprint Gait Speed Predicts 30-Day Mortality After Transcatheter Aortic Valve Replacement: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry
    Joakim Alfredsson
    From Duke Clinical Research Institute, Durham, NC J Alfredsson, A s, E D P, K P A Department of Cardiology and Department of Medical and Health Sciences, Linkoping University, Sweden J Alfredsson Duke University School of Medicine, Durham, NC J M B, R M, E D P, S V, K P A Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada J Afilalo University of Colorado School of Medicine, Aurora J S R Massachusetts General Hospital, Boston D S and Baylor Scott and White Health, Plano, TX M J M
    Circulation 133:1351-9. 2016
    ..Surgical risk scores do not include frailty assessments (eg, gait speed), which are of particular importance for patients with severe aortic stenosis considering transcatheter aortic valve replacement...
  28. doi request reprint Androgen deficiency as a biological determinant of frailty: hope or hype?
    Jonathan Afilalo
    Divisions of Cardiology and Clinical Epidemiology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Am Geriatr Soc 62:1174-8. 2014
    ..Consideration of these biases is vital to ensure that future epidemiological studies and interventional trials generate valid conclusions. ..
  29. pmc A simple echocardiographic prediction rule for hemodynamics in pulmonary hypertension
    Alexander R Opotowsky
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Circ Cardiovasc Imaging 5:765-75. 2012
    ..Differentiating patients with primarily elevated pulmonary vascular resistance (PVR) from those with PH predominantly because of elevated left-sided filling pressure is critical...
  30. doi request reprint Right atrial size relates to right ventricular end-diastolic pressure in an adult population with congenital heart disease
    Doan Hoa Do
    Echocardiography Laboratory, Division of Cardiology, Sir Mortimer B Davis Jewish General Hospital, Montreal, Canada
    Echocardiography 28:109-16. 2011
    ..We tested the hypothesis that right atrial (RA) size measured by echocardiography was correlated to invasive parameters of RV diastolic filling...
  31. pmc Symptom-to-door time in ST segment elevation myocardial infarction: overemphasized or overlooked? Results from the AMI-McGill study
    Jonathan Afilalo
    Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec
    Can J Cardiol 24:213-6. 2008
    ..Ischemic time is a major determinant of infarct size in ST segment elevation myocardial infarction (STEMI). Emphasis is placed on reducing the door-to-reperfusion therapy time component, whereas the symptom-to-door time is often overlooked...
  32. ncbi request reprint Long-term risk of ischemic stroke associated with rofecoxib
    Jonathan Afilalo
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, 3755 Cote Ste Catherine Suite A 118, Montreal, Quebec, Canada
    Cardiovasc Drugs Ther 21:117-20. 2007
    ..These trials were limited by short-term follow-up and non-placebo controls. Extended follow-up data from the APPROVe trial has shed some light on the incidence of ischemic stroke after rofecoxib use...
  33. pmc Intensive statin therapy in acute coronary syndromes and stable coronary heart disease: a comparative meta-analysis of randomised controlled trials
    Jonathan Afilalo
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Heart 93:914-21. 2007
    ..Intensive statin therapy reduces major adverse cardiovascular events (MACE), but the effect on mortality is unclear...
  34. pmc Cancer risk related to low-dose ionizing radiation from cardiac imaging in patients after acute myocardial infarction
    Mark J Eisenberg
    Division of Cardiology, Jewish General Hospital, Montreal, Que
    CMAJ 183:430-6. 2011
    ..Patients exposed to low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction may be at increased risk of cancer...
  35. doi request reprint Prognostic and Therapeutic Implications of Frailty in Older Adults with Heart Failure
    Michael Goldfarb
    Division of Cardiology, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine Rd, Montreal, QC, H3T 1E2, Canada
    Curr Cardiol Rep 17:92. 2015
    ..While more data accrues, difficult therapeutic decisions should be individualized using a shared patient-centered decision making approach. ..
  36. doi request reprint Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and t
    Lawrence G Rudski
    Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Am Soc Echocardiogr 23:685-713; quiz 786-8. 2010
  37. doi request reprint Therapeutic interventions for frail elderly patients: part I. Published randomized trials
    Lior Bibas
    Department of Medicine, McGill University, Montreal, Canada Division of Cardiology, McGill University, Montreal, Canada
    Prog Cardiovasc Dis 57:134-43. 2014
    ..The main findings of these trials are explored along with a discussion of their relative merits and limitations. ..
  38. ncbi request reprint Age-related changes in lamin A/C expression in cardiomyocytes
    Jonathan Afilalo
    Division of Internal Medicine, Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 293:H1451-6. 2007
    ..This is the first study to show that normal aging is associated with reduced expression and altered distribution of lamin A/C in nuclei of cardiomyocytes...