Mohamed Abdel-Aziz

Summary

Publications

  1. doi request reprint Synthesis, cytotoxic properties and tubulin polymerization inhibitory activity of novel 2-pyrazoline derivatives
    Mohamed Abdel-Aziz
    Faculty of Pharmacy, Medicinal Chemistry Department, Minia University, Minia, Egypt
    Arch Pharm (Weinheim) 345:535-48. 2012
  2. doi request reprint Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 45:3384-8. 2010
  3. doi request reprint N-malonyl-1,2-dihydroisoquinoline as a novel carrier for specific delivery of drugs to the brain
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Arch Pharm (Weinheim) 343:54-60. 2010
  4. doi request reprint Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Eur J Med Chem 44:3480-7. 2009
  5. doi request reprint 1-Malonyl-1,4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain
    Heba A Hassan
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Bioorg Med Chem 17:1681-92. 2009
  6. doi request reprint Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide
    el Shimaa M N Abdel-Hafez
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Bioorg Med Chem 17:3829-37. 2009
  7. doi request reprint Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids
    Mai A E Mourad
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 54:907-13. 2012
  8. doi request reprint New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities
    Mohamed Abdel-Aziz
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Bioorg Med Chem 21:3839-49. 2013
  9. doi request reprint Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 69:427-38. 2013
  10. doi request reprint Synthesis, anti-inflammatory activity and ulcerogenic liability of novel nitric oxide donating/chalcone hybrids
    Gamal El Din A A Abuo-Rahma
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Bioorg Med Chem 20:195-206. 2012

Collaborators

  • Gary A Piazza
  • Alaa A Hassan
  • S Bruce King
  • Kamel A Metwally
  • Mohamed A Morsy
  • Gamal El Din A A Abuo-Rahma
  • Hassan H Farag
  • Hamdy M Abdel-Rahman
  • Mai A E Mourad
  • Mai E Shoman
  • Samar Hafez Abbas
  • Heba S Abd-Ellah
  • Joshua C Canzoneri
  • Heba A H Mohamed
  • Bernard D Gary
  • Tamer S Kaoud
  • Eman A M Beshr
  • Omar M Aly
  • el Shimaa M N Abdel-Hafez
  • Heba A Hassan
  • Heather N Tinsley
  • Eman A Beshr
  • Amira M Gamal-Eldeen
  • Al Shaimaa F F Ahmed
  • Taha F S Ali
  • Nahla A Farag
  • Mohamed F Radwan

Detail Information

Publications21

  1. doi request reprint Synthesis, cytotoxic properties and tubulin polymerization inhibitory activity of novel 2-pyrazoline derivatives
    Mohamed Abdel-Aziz
    Faculty of Pharmacy, Medicinal Chemistry Department, Minia University, Minia, Egypt
    Arch Pharm (Weinheim) 345:535-48. 2012
    ..Molecular modeling studies involving compound 6e with the colchicine binding site of α,β-tubulin revealed hydrogen-bonding and hydrophobic interactions with several amino acids in the colchicine binding site of β-tubulin...
  2. doi request reprint Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 45:3384-8. 2010
    ..tuberculosis H(37)Rv (IC(90) = 16.87 microg/mL). Details of the structure-activity and structure-cytotoxicity relationships are discussed...
  3. doi request reprint N-malonyl-1,2-dihydroisoquinoline as a novel carrier for specific delivery of drugs to the brain
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Arch Pharm (Weinheim) 343:54-60. 2010
    ..The in-vivo distribution studies showed that these N-malonyl-1,2-dihydroisoquinoline chemical delivery systems were able to cross the blood-brain barrier at detectable concentrations...
  4. doi request reprint Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Eur J Med Chem 44:3480-7. 2009
    ..p. injection of PTZ at a dose level of 20 mg kg(-1). The results of anticonvulsant activity are nearly close to phenobarbital sodium at a dose level of 30 mg kg(-1) and more potent than phenytoin sodium at a dose level of 30 mg kg(-1)...
  5. doi request reprint 1-Malonyl-1,4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain
    Heba A Hassan
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Bioorg Med Chem 17:1681-92. 2009
    ..8%, 86.7% and 90.20% of the activity of imipramine, respectively. The other derivatives 9a and 9c exhibited moderate antidepressant activity compared with imipramine...
  6. doi request reprint Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide
    el Shimaa M N Abdel-Hafez
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Bioorg Med Chem 17:3829-37. 2009
    ..In general, structural modification of compound 2 either to nitrate ester or oxime hybrids showed better anti-inflammatory with less ulcerogenic liability than their corresponding starting intermediates...
  7. doi request reprint Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids
    Mai A E Mourad
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 54:907-13. 2012
    ..The nitrate ester 3a exhibited moderate selectivity toward colon cancer subpanel with selectivity ratio of 5.87 at TGI level...
  8. doi request reprint New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities
    Mohamed Abdel-Aziz
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Bioorg Med Chem 21:3839-49. 2013
    ..The NO-donating oxime 6i revealed significant activity against renal cancer A498 cell lines with 50.52 cell growth inhibition...
  9. doi request reprint Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 69:427-38. 2013
    ..Studying of the solubility and partition coefficient revealed higher lipophilicity of the hybrids 3a-j compared to the parent ciprofloxacin...
  10. doi request reprint Synthesis, anti-inflammatory activity and ulcerogenic liability of novel nitric oxide donating/chalcone hybrids
    Gamal El Din A A Abuo-Rahma
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Bioorg Med Chem 20:195-206. 2012
    ..The incorporation of the NO-donating group into the parent chalcone derivatives caused a moderate increase in the anti-inflammatory activity with a marked decrease in gastric ulcerations compared to their parent chalcone derivatives...
  11. doi request reprint Synthesis, cytotoxic activity, and tubulin polymerization inhibitory activity of new pyrrol-2(3H)-ones and pyridazin-3(2H)-ones
    Samar Hafez Abbas
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Bioorg Chem 66:46-62. 2016
    ..Molecular modeling study using MOE® program indicated that most of the target compounds showed good binding of β-subunit of tubulin with the binding free energy (dG) values about -10kcal/mole. ..
  12. doi request reprint Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors
    Hamdy M Abdel-Rahman
    Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
    Arch Pharm (Weinheim) 349:104-11. 2016
    ..Docking of 6, 12, and 14 into the active site of PDE4B illustrates their possible binding mode and provides insights for further optimization of this drug scaffold. ..
  13. doi request reprint Novel 1,3,4-oxadiazole/oxime hybrids: Synthesis, docking studies and investigation of anti-inflammatory, ulcerogenic liability and analgesic activities
    Heba S Abd-Ellah
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Bioorg Chem 69:48-63. 2016
    ..The designed strategy was applied to ibuprofen to introduce ibuprofen/oxadiazole/NO hybrid. The synthesized ibuprofen hybrid is a promising alternative to ibuprofen having similar anti-inflammatory activity but with safer GIT profile...
  14. doi request reprint 1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities
    Gamal El Din A A Abuo-Rahma
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Eur J Med Chem 71:185-98. 2014
    ..Compound 7k was found to be with high selectivity against CNS subpanel with selectivity ratio of 11.99 at GI₅₀ level...
  15. doi request reprint Synthesis and antibacterial activity of 4-aryl-2-(1-substituted ethylidene)thiazoles
    Alaa A Hassan
    Chemistry Department, Faculty of Science, Minia University, El Minia, Egypt
    Arch Pharm (Weinheim) 346:562-70. 2013
    ..05 to 0.4 µg/mL. The rest of the tested compounds gave significant antibacterial activities against different Gram-negative bacterial strains. ..
  16. doi request reprint Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives
    Mai E Shoman
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Eur J Med Chem 44:3068-76. 2009
    ....
  17. pmc New acyloxy nitroso compounds with improved water solubility and nitroxyl (HNO) release kinetics and inhibitors of platelet aggregation
    Heba A H Mohamed
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Bioorg Med Chem 23:6069-77. 2015
    ..These acyloxy nitroso compounds augment the range of release for this group of HNO donors and should be valuable tools in the further study of HNO biology. ..
  18. ncbi request reprint 1,3,4-oxadiazole-2-thione Derivatives; Novel Approach for Anticancer and Tubulin Polymerization Inhibitory Activities
    Mohamed Abdel-Aziz
    Postal address Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Anticancer Agents Med Chem 16:269-77. 2015
    ..1 % inhibition of the original control tubulin. Moreover, the mechanism of tubulin polymerization inhibition was confirmed by immunofluorescence assay, flow cytometry, and docking study. ..
  19. doi request reprint Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies
    Hamdy M Abdel-Rahman
    Faculty of Pharmacy, Medicinal Chemistry Department, Assiut University, Assiut, Egypt
    Arch Pharm (Weinheim) 347:650-7. 2014
    ..Docking of compound 7 in the active site of PDE4B illustrates its possible binding mode and provides insight for further optimizations of this novel scaffold for inhibiting PDE4...
  20. doi request reprint Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies
    Gamal El Din A A Abuo-Rahma
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Eur J Med Chem 83:398-408. 2014
    ..The additional H-bonds with the oxygen of the amide and/or H of NH of the amide with the amino acid residues may be responsible for the higher binding affinity of this group of compounds towards COX-2. ..
  21. doi request reprint 1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity
    Mohamed Abdel-Aziz
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Eur J Med Chem 77:155-65. 2014
    ..2 μM) and 6 (COX-1 IC50 = 39.8 μM; COX-2 IC50 = 46.3 μM) are the most potent COX inhibitors in the tested compounds. The binding mode for some of the tested compounds to the enzymes was predicted using docking studies. ..