acute lung injury


Summary: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).

Top Publications

  1. Antonelli M, Azoulay E, Bonten M, Chastre J, Citerio G, Conti G, et al. Year in review in Intensive Care Medicine 2009. Part III: mechanical ventilation, acute lung injury and respiratory distress syndrome, pediatrics, ethics, and miscellanea. Intensive Care Med. 2010;36:567-84 pubmed publisher
  2. Rubenfeld G. How much PEEP in acute lung injury. JAMA. 2010;303:883-4 pubmed publisher
  3. Gong M. Gene association studies in acute lung injury: replication and future direction. Am J Physiol Lung Cell Mol Physiol. 2009;296:L711-2 pubmed publisher
  4. Gao W, Zhao B, Liu L, Yuan Q, Wu X, Xia Z. Myocardial ischemic post-conditioning protects the lung against myocardial ischemia/reperfusion-induced damage by activating GSK-3?. Acta Cir Bras. 2017;32:376-387 pubmed publisher
    ..To investigate whether modulating GSK-3? could attenuate myocardial ischemia reperfusion injury (MIRI) induced acute lung injury (ALI) and analyze the underlying mechanism...
  5. Zhang D, Li C, Song Y, Zhou J, Li Y, Li J, et al. Integrin ?v?5 inhibition protects against ischemia-reperfusion-induced lung injury in an autophagy-dependent manner. Am J Physiol Lung Cell Mol Physiol. 2017;313:L384-L394 pubmed publisher
    Integrin ?v?5 mediates pulmonary endothelial barrier function and acute lung injury (LI), but its roles in cell apoptosis and autophagy are unclear...
  6. Xu X, Zhu Q, Zhang R, Wang Y, Niu F, Wang W, et al. ITRAQ-Based Proteomics Analysis of Acute Lung Injury Induced by Oleic Acid in Mice. Cell Physiol Biochem. 2017;44:1949-1964 pubmed publisher
    ..between differentially expressed proteins (DEPs) and the pathogenesis of oleic acid (OA)-induced acute lung injury (ALI) in mice...
  7. Braunschweig C, Sheean P, Peterson S, Perez S, Freels S, Lateef O, et al. Response to Berger and Pichard and Heyland et al. JPEN J Parenter Enteral Nutr. 2015;39:144-5 pubmed publisher
  8. Zhao Y, Lv W, Zhou J. Role of carbonyl sulfide in acute lung injury following limb ischemia/reperfusion in rats. Eur J Med Res. 2017;22:12 pubmed publisher
    To investigate the effect of carbonyl sulfide (COS) on limb ischemia/reperfusion (I/R)-induced acute lung injury (ALI) and the associated mechanism in rats. ALI was induced by bilateral hind limb I/R in Sprague-Dawley (SD) rats...
  9. Chen Q, Song S, Chen Q, Zeng C, Zheng X, Wang J, et al. Silencing airway epithelial cell-derived hepcidin exacerbates sepsis induced acute lung injury. Crit Care. 2014;18:470 pubmed publisher
    ..We therefore sought to investigate the role of airway epithelial cell-derived hepcidin in sepsis-induced acute lung injury. Acute lung injury was induced by polymicrobial sepsis via cecal ligation and puncture (CLP) surgery...

More Information


  1. Mallavia B, Kwaan N, Marschner S, Yonemura S, Looney M. Mirasol pathogen reduction technology treatment of human whole blood does not induce acute lung injury in mice. PLoS ONE. 2017;12:e0178725 pubmed publisher blood cells and whether these cells could damage the transfused recipient, including the development of acute lung injury/acute respiratory distress syndrome...
  2. Liu X, Chen Q, Shi S, Shi Z, Lin R, Tan L, et al. Plasma sRAGE enables prediction of acute lung injury after cardiac surgery in children. Crit Care. 2012;16:R91 pubmed publisher
    b>Acute lung injury (ALI) after cardiac surgery is associated with a high postoperative morbidity and mortality, but few predictors are known for the occurrence of the complication...
  3. Rice T, Wheeler A, Thompson B, Steingrub J, Hite R, Moss M, et al. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA. 2012;307:795-803 pubmed publisher
    The amount of enteral nutrition patients with acute lung injury need is unknown...
  4. Perel A. Extravascular lung water and the pulmonary vascular permeability index may improve the definition of ARDS. Crit Care. 2013;17:108 pubmed publisher
    ..This commentary discusses the merits and limitations of this study in view of the potential improvement that transpulmonary thermodilution may bring to the definition of ARDS. ..
  5. Pelosi P, Gama de Abreu M. Lung injury prediction models to improve perioperative management: let's hit the bull's-eye!. Anesthesiology. 2011;115:10-1 pubmed publisher
  6. Gralinski L, Bankhead A, Jeng S, Menachery V, Proll S, Belisle S, et al. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. MBio. 2013;4: pubmed publisher
    ..we have developed an unbiased modeling approach to identify new pathways and network connections mediating acute lung injury, using severe acute respiratory syndrome coronavirus (SARS-CoV) as a model pathogen...
  7. Futier E, Marret E, Jaber S. Perioperative positive pressure ventilation: an integrated approach to improve pulmonary care. Anesthesiology. 2014;121:400-8 pubmed publisher
  8. Gong Y, Lan H, Yu Z, Wang M, Wang S, Chen Y, et al. Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells. Biochem Biophys Res Commun. 2017;491:522-529 pubmed publisher
    Sepsis-related acute lung injury (ALI) is characterized by excessive lung inflammation and apoptosis of alveolar epithelial cells resulting in acute hypoxemic respiratory failure...
  9. Shah D, Romero F, Guo Z, Sun J, Li J, Kallen C, et al. Obesity-Induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury. Am J Respir Cell Mol Biol. 2017;57:204-215 pubmed publisher
    ..pulmonary vascular endothelial dysfunction, which is associated with enhanced susceptibility to LPS-induced acute lung injury. Here, we demonstrate that lung endothelial dysfunction in diet-induced obese mice coincides with increased ..
  10. de Souza Xavier Costa N, Ribeiro Júnior G, Dos Santos Alemany A, Belotti L, Zati D, Frota Cavalcante M, et al. Early and late pulmonary effects of nebulized LPS in mice: An acute lung injury model. PLoS ONE. 2017;12:e0185474 pubmed publisher
    ..This study presents a feasible animal model of acute lung injury (ALI) using nebulized lipopolysaccharide (LPS) in a non-invasive approach, focusing on its short and long-..
  11. Tao L, Cao F, Xu G, Xie H, Zhang M, Zhang C. Mogroside IIIE Attenuates LPS-Induced Acute Lung Injury in Mice Partly Through Regulation of the TLR4/MAPK/NF-?B Axis via AMPK Activation. Phytother Res. 2017;31:1097-1106 pubmed publisher
    b>Acute lung injury (ALI) often leads to high mortality, and there is as yet no effective drug treatment...
  12. Chen W, Yan G, Lu Z, Lu G. [Effects and mechanisms of high-volume hemofiltration on endotoxin-induced acute lung injury of piglets]. Zhonghua Er Ke Za Zhi. 2017;55:343-348 pubmed publisher
    ..on cardiopulmonary functions, lung fluid balance, lung damage and cytokine expression in endotoxin-induced acute lung injury piglet model, and to further evaluate the value of high-volume hemofiltration in acute lung injury...
  13. Fusco R, Gugliandolo E, Biundo F, Campolo M, Di Paola R, Cuzzocrea S. Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy. FASEB J. 2017;31:3497-3511 pubmed publisher
    ..Fusco, R. Gugliandolo, E., Biundo, F., Campolo, M., Di Paola, R., Cuzzocrea, S. Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy. ..
  14. Zhu G, Xin X, Liu Y, Huang Y, Li K, Wu C. Geraniin attenuates LPS-induced acute lung injury via inhibiting NF-?B and activating Nrf2 signaling pathways. Oncotarget. 2017;8:22835-22841 pubmed publisher
    ..The aim of the study is to investigate the therapeutic effects of geraniin on LPS-induced acute lung injury (ALI) in mice. The mice were intranasal adminisration of LPS for 12 h...
  15. Erdem A, Gedikli E, Yersal N, Karaismailoğlu S, Muftuoglu S, Fadillioglu E, et al. Protective role of erdosteine pretreatment on oleic acid-induced acute lung injury. J Surg Res. 2017;213:234-242 pubmed publisher
    ..We evaluated the protective effect of erdosteine pretreatment on oleic acid (OA)-induced acute lung injury. Twenty-four male Wistar Albino rats were assigned to four treatments: control (oral saline + 50 ?L ..
  16. Proia R, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest. 2015;125:1379-87 pubmed publisher
    ..The unique mode of signaling of this lysophospholipid mediator is providing novel opportunities for therapeutic intervention, with possibilities to target not only GPCRs but also transporters, metabolic enzymes, and chaperones. ..
  17. Qi D, He J, Wang D, Deng W, Zhao Y, Ye Y, et al. 17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro. Respir Res. 2014;15:159 pubmed publisher
    17β-estradiol can suppress acute lung injury (ALI) and regulate alveolar epithelial sodium channel (ENaC). However the relationship between these two functions remains unclear...
  18. Heyland D, Dhaliwal R, Lemieux M. More questions than answers. JPEN J Parenter Enteral Nutr. 2015;39:143 pubmed publisher
  19. Belhaj A, Dewachter L, Rorive S, Remmelink M, Weynand B, Melot C, et al. Mechanical versus humoral determinants of brain death-induced lung injury. PLoS ONE. 2017;12:e0181899 pubmed publisher
  20. Hergrueter A, Nguyen K, Owen C. Matrix metalloproteinases: all the RAGE in the acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2011;300:L512-5 pubmed publisher
  21. Wang W, Yang P, Zhong Y, Zhao Z, Xing L, Zhao Y, et al. Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury. Cell Res. 2013;23:577-80 pubmed publisher
  22. Fan W, Nakazawa K, Abe S, Inoue M, Kitagawa M, Nagahara N, et al. Inhaled aerosolized insulin ameliorates hyperglycemia-induced inflammatory responses in the lungs in an experimental model of acute lung injury. Crit Care. 2013;17:R83 pubmed publisher
    Previous studies have shown that patients with diabetes mellitus appear to have a lower prevalence of acute lung injury. We assumed that insulin prescribed to patients with diabetes has an anti-inflammatory property and pulmonary ..
  23. Mamatjan Y, Grychtol B, Gaggero P, Justiz J, Koch V, Adler A. Evaluation and real-time monitoring of data quality in electrical impedance tomography. IEEE Trans Med Imaging. 2013;32:1997-2005 pubmed publisher
    ..The proposed measure can thus be used for real-time assessment of EIT data quality and, hence, to indicate the reliability of any derived physiological information. ..
  24. Piper A, Song Y, Eves N, Maher T. Year in review 2013: Acute lung injury, interstitial lung diseases, sleep and physiology. Respirology. 2014;19:428-37 pubmed publisher
  25. Popovsky M. Transfusion-related acute lung injury: three decades of progress but miles to go before we sleep. Transfusion. 2015;55:930-4 pubmed publisher
  26. Moraes L, Santos C, Santos R, Cruz F, Saddy F, Morales M, et al. Effects of sigh during pressure control and pressure support ventilation in pulmonary and extrapulmonary mild acute lung injury. Crit Care. 2014;18:474 pubmed publisher
    ..during PCV or PSV on the lung and distal organs in experimental pulmonary (p) and extrapulmonary (exp) mild acute lung injury (ALI)...
  27. Lee H, Zhang D, Wu J, Otterbein L, Jin Y. Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin ?1 Recycling. J Immunol. 2017;199:1453-1464 pubmed publisher
    Robust lung inflammation is one of the prominent features in the pathogenesis of acute lung injury (ALI). Macrophage migration and recruitment are often seen at the early stage of lung inflammatory responses to noxious stimuli...
  28. Londhe C, Ganeriwal A, deSouza R. Study of clinical profile of acute respiratory distress syndrome and acute lung injury in Plasmodium vivax malaria. J Vector Borne Dis. 2014;51:339-42 pubmed
  29. Su X. Leading neutrophils to the alveoli: who is the guider?. Am J Respir Crit Care Med. 2012;186:472-3 pubmed publisher
  30. Fan X, Xue F, Zhang Y, Xing X, Liu H, Mao S, et al. The Apelin-APJ axis is an endogenous counterinjury mechanism in experimental acute lung injury. Chest. 2015;147:969-978 pubmed publisher
    ..The apelin-APJ signaling pathway is an endogenous anti-injury and organ-protective mechanism that is activated during ARDS to counteract the injury response and to prevent uncontrolled lung injury. ..
  31. Ntshalintshali S, Manzini T. Paraquat poisoning: Acute lung injury - a missed diagnosis. S Afr Med J. 2017;107:399-401 pubmed publisher
    ..Lastly, we look at the importance of avoiding oxygen supplementation, and early administration of immunosuppressive therapy, to improve outcome. ..
  32. Yan Y, Liu Q, Li N, Du J, Li X, Li C, et al. Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse. Sci China Life Sci. 2015;58:208-11 pubmed publisher
  33. Rocha Pereira A, Rodrigues M, Novaes R, Caldas I, Martins Souza R, Costa Pereira A. Lipopolysaccharide-induced acute lung injury in mice chronically infected by Schistosoma mansoni. Exp Parasitol. 2017;178:21-29 pubmed publisher
    ..As schistosomiasis develops as a chronic condition, long-term exposure to endotoxins could aggravate the granulomatous process, an issue that requires further investigation. ..
  34. Lockyer P, Mao H, Fan Q, Li L, Yu Lee L, Eissa N, et al. LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation. Arterioscler Thromb Vasc Biol. 2017;37:1524-1535 pubmed publisher
    ..To address this question, we investigated the role of BMPER during lipopolysaccharide-induced acute lung injury. Mice missing 1 allele of BMPER (BMPER+/- mice used in the place of BMPER-/- mice that ..
  35. Kovalchuk N, Kelty J, Li L, Hartog M, Zhang Q, Edwards P, et al. Impact of hepatic P450-mediated biotransformation on the disposition and respiratory tract toxicity of inhaled naphthalene. Toxicol Appl Pharmacol. 2017;329:1-8 pubmed publisher
    ..This hepatic contribution to the airway toxicity of inhaled NA may be an important risk factor for individuals with diminished bioactivation activity in the lung. ..
  36. Chen X, Zhang X, Zhang J, Gao Y, Yang Z, Li S, et al. Attenuation of acute lung injury in a rat model by Semen Cassiae. BMC Complement Altern Med. 2017;17:234 pubmed publisher
    b>Acute lung injury (ALI) is an inflammatory disorder. Semen Cassiae has potent anti-inflammatory activities...
  37. Zhang Q, Lei H, Wang P, Ma Z, Zhang Y, Wu J, et al. Bioactive Components from Qingwen Baidu Decoction against LPS-Induced Acute Lung Injury in Rats. Molecules. 2017;22: pubmed publisher
    ..the change of the constituents in different extracts of QBD and the pharmacological effect in a rat model of acute lung injury (ALI) induced by lipopolysaccharide (LPS)...
  38. Lasocki S, Gaillard T, Rineau E. Iron is essential for living!. Crit Care. 2014;18:678 pubmed publisher
    ..The recent study by Chen and colleagues in Critical Care reminds us of this elegantly. In a mouse model of acute lung injury, they showed that silencing hepcidin (the master regulator of iron metabolism) locally in airway epithelial ..
  39. Matsuo S, Yang W, Aziz M, Jacob A, Wang P. Cyclic arginine-glycine-aspartate attenuates acute lung injury in mice after intestinal ischemia/reperfusion. Crit Care. 2013;17:R19 pubmed publisher
    ..Intestinal ischemia is a critical problem resulting in multiple organ failure and high mortality of 60 to 80%. Acute lung injury (ALI) is a common complication after intestinal ischemia/reperfusion (I/R) injuries and contributes to the ..
  40. Kress J. Mortality is the only relevant outcome in ARDS: no. Intensive Care Med. 2015;41:144-6 pubmed publisher
  41. Lacy P. Metabolomics of sepsis-induced acute lung injury: a new approach for biomarkers. Am J Physiol Lung Cell Mol Physiol. 2011;300:L1-3 pubmed publisher
  42. Ho Y, Lee S, Yang M, Huang Liu R, Lee C, Li Y, et al. Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice via Akt-NF?B pathway. Chem Biol Interact. 2017;271:9-14 pubmed publisher
    ..b>Acute lung injury (ALI) is an acute pulmonary inflammatory disorder with high morbidity and mortality rate...
  43. Juffermans N, Vlaar A. Possible TRALI is a real entity. Transfusion. 2017;57:2539-2541 pubmed publisher
    After the consensus definition of transfusion-related acute lung injury (TRALI), studies have shown that the incidence of TRALI is high in critically ill and injured patients...
    b>Acute Lung Injury (ALI) results into severe inflammation and oxidative stress to the pulmonary tissue. Rhamnazin is a natural flavonoid and known for its antioxidant and anti-inflammatory properties...
  45. Makita S, Munakata W, Watabe D, Maeshima A, Taniguchi H, Toyoda K, et al. Azacitidine-induced acute lung injury in a patient with therapy-related myelodysplastic syndrome. J Int Med Res. 2017;45:886-893 pubmed publisher
    ..Here, we report the case of a patient with MDS who suffered from a rare adverse event, an acute lung injury (ALI), which was suspected to have been caused by azacitidine and was successfully treated with ..
  46. Meduri G, Marik P, Annane D. Prolonged glucocorticoid treatment in acute respiratory distress syndrome: Evidence supporting effectiveness and safety. Crit Care Med. 2009;37:1800-3 pubmed publisher
  47. Jacobson J, Birukov K. Activation of NFkB and coagulation in lung injury by hyperoxia and excessive mechanical ventilation: one more reason "low and slow" is the way to go?. Transl Res. 2009;154:219-21 pubmed publisher
  48. Huang X, Zhao W, Hu D, Han X, Wang H, Yang J, et al. Resveratrol efficiently improves pulmonary function via stabilizing mast cells in a rat intestinal injury model. Life Sci. 2017;185:30-37 pubmed publisher
    Intestinal ischemia/reperfusion (IIR) leads to acute lung injury (ALI) distally by aggravating pulmonary oxidative stress. Resveratrol is effective in attenuating ALI through its antioxidant capacity...
  49. Wang B, Mao X. [Protective effect of quercetin against seawater instillation-induced acute lung injury through preventing M1 polarization of macrophages in mice]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:751-755 pubmed
    Objective To study the protective effect of quercetin against seawater instillation-induced acute lung injury (SW-ALI) and explore the roles of M1polarization of macrophages and M1 macrophage-mediated inflammation in the protective ..
  50. Matthay M, Idell S. Update on acute lung injury and critical care medicine 2009. Am J Respir Crit Care Med. 2010;181:1027-32 pubmed publisher
  51. Santos C, Santos R, Moraes L, Samary C, Felix N, Silva J, et al. Effects of pressure support and pressure-controlled ventilation on lung damage in a model of mild extrapulmonary acute lung injury with intra-abdominal hypertension. PLoS ONE. 2017;12:e0178207 pubmed publisher
    ..lung injury (VILI) compared to pressure-controlled ventilation (PCV) in mild extrapulmonary acute lung injury (ALI) with IAH...
  52. Cybulska P, Goss C, Tew W, Parameswaran R, Sonoda Y. Indications for and complications of transfusion and the management of gynecologic malignancies. Gynecol Oncol. 2017;146:416-426 pubmed publisher
  53. Berger M, Pichard C. Understanding the causes of death in INTACT by Braunschweig et al. JPEN J Parenter Enteral Nutr. 2015;39:144 pubmed publisher