cumulative trauma disorders

Summary

Summary: Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.

Top Publications

  1. Ratzlaff C, Gillies J, Koehoorn M. Work-related repetitive strain injury and leisure-time physical activity. Arthritis Rheum. 2007;57:495-500 pubmed
    ..To investigate the relationship between leisure-time physical activity and work-related repetitive strain injury (RSI), adjusted for sociodemographic characteristics and work-related physical and stress factors...
  2. Gallagher S, Heberger J. Examining the interaction of force and repetition on musculoskeletal disorder risk: a systematic literature review. Hum Factors. 2013;55:108-24 pubmed
    ..Repetition seems to result in modest increases in risk for low-force tasks but rapid increases in risk for high-force tasks. This interaction may be representative of a fatigue failure process in affected tissues. ..
  3. Berry S, Susitaival P, Ahmadi A, Schenker M. Cumulative trauma disorders among California veterinarians. Am J Ind Med. 2012;55:855-61 pubmed publisher
    The prevalence of cumulative trauma disorders (CTDs) in veterinarians has not been adequately studied.
  4. Gao H, Fisher P, Lambi A, WADE C, Barr Gillespie A, Popoff S, et al. Increased serum and musculotendinous fibrogenic proteins following persistent low-grade inflammation in a rat model of long-term upper extremity overuse. PLoS ONE. 2013;8:e71875 pubmed publisher
    ..Serum TNF-?, IL-6, TGFB1, CTGF and MMP2 may serve as serum biomarkers of work-related musculoskeletal disorders, although further studies in humans are needed. ..
  5. Kietrys D, Barr Gillespie A, Amin M, WADE C, Popoff S, Barbe M. Aging contributes to inflammation in upper extremity tendons and declines in forelimb agility in a rat model of upper extremity overuse. PLoS ONE. 2012;7:e46954 pubmed publisher
    ..Greater inflammatory changes in aged HRLF rat tendons were observed, increases associated temporally with decreased forelimb agility and lack of improvement in task success. ..
  6. Opar D, Williams M, Shield A. Hamstring strain injuries: factors that lead to injury and re-injury. Sports Med. 2012;42:209-26 pubmed publisher
    ..This remains an area for future research and practitioners need to remain aware of the multifactoral nature of HSIs if injury rates are to decline...
  7. Silva R, Glazebrook M, Campos V, Vasconcelos A. Achilles tendinosis: a morphometrical study in a rat model. Int J Clin Exp Pathol. 2011;4:683-91 pubmed
    ..The combination of staining techniques and morphometry used here to describe the evolution of lesions occurring in a rat model system has proved to be suited for the study of induced Achilles tendinosis...
  8. Xin D, Harris M, WADE C, Amin M, Barr A, Barbe M. Aging enhances serum cytokine response but not task-induced grip strength declines in a rat model of work-related musculoskeletal disorders. BMC Musculoskelet Disord. 2011;12:63 pubmed publisher
    ..Thus, here, we examined their levels at 12 weeks in young rats. Since aging is known to enhance serum cytokine levels, we also examined aged rats...
  9. Riondino S, La Farina F, Martini F, Guadagni F, Ferroni P. Functional impairment in video terminal operators is related to low-grade inflammation. Int Arch Occup Environ Health. 2011;84:745-51 pubmed publisher
    ..Aim of this study was to analyze systemic inflammatory changes in relation to the possible occurrence of pain and/or disability in video terminal operators (VTOs) undergoing upper-extremity repetitive stress due to chronic overuse...

More Information

Publications69

  1. Jacobsson J, Timpka T, Kowalski J, Nilsson S, Ekberg J, Renstrom P. Prevalence of musculoskeletal injuries in Swedish elite track and field athletes. Am J Sports Med. 2012;40:163-9 pubmed publisher
    ..Little is known of injury patterns in track and field (athletics). Injury prevalence has been proposed as the most appropriate measure of the injury rate in sports where athletes are at risk for overuse problems...
  2. Andersson G, Backman L, Scott A, Lorentzon R, Forsgren S, Danielson P. Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model. Br J Sports Med. 2011;45:1017-22 pubmed publisher
    ..Considering the known effects of SP, one might ask whether SP contributes to these changes...
  3. IJmker S, Huysmans M, Blatter B, van der Beek A, Van Mechelen W, Bongers P. Should office workers spend fewer hours at their computer? A systematic review of the literature. Occup Environ Med. 2007;64:211-22 pubmed
  4. Miranda H, Punnett L, Viikari Juntura E, Heliovaara M, Knekt P. Physical work and chronic shoulder disorder. Results of a prospective population-based study. Ann Rheum Dis. 2008;67:218-23 pubmed
    ..Early preventive measures at the workplace may have long-lasting health benefits for the shoulder. ..
  5. Elliott M, Barr A, Clark B, Wade C, Barbe M. Performance of a repetitive task by aged rats leads to median neuropathy and spinal cord inflammation with associated sensorimotor declines. Neuroscience. 2010;170:929-41 pubmed publisher
    ..Thus, aged rats performing a repetitive task exhibited sensorimotor declines that were associated with decreased median nerve conduction, and increased pro-inflammatory cytokines in the median nerve and cervical spinal cord neurons...
  6. Andersen J, Harhoff M, Grimstrup S, Vilstrup I, Lassen C, Brandt L, et al. Computer mouse use predicts acute pain but not prolonged or chronic pain in the neck and shoulder. Occup Environ Med. 2008;65:126-31 pubmed
    ..Moreover, there seems to be no relationship between computer use and prolonged and chronic neck and shoulder pain. ..
  7. Helliwell P, Taylor W. Repetitive strain injury. Postgrad Med J. 2004;80:438-43 pubmed
    ..Return to work should be encouraged and facilitated by medical interventions and light duty options. Rehabilitation programmes may be of use in chronic cases. ..
  8. Mathiassen S. Diversity and variation in biomechanical exposure: what is it, and why would we like to know?. Appl Ergon. 2006;37:419-27 pubmed
    ..Operational methods for assessing these concepts are also discussed. ..
  9. Bahr R. No injuries, but plenty of pain? On the methodology for recording overuse symptoms in sports. Br J Sports Med. 2009;43:966-72 pubmed publisher
    ..In conclusion, new approaches are needed to develop more appropriate methodology to quantify overuse injuries in studies. ..
  10. Perry S, McIlhenny S, Hoffman M, Soslowsky L. Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse animal model. J Shoulder Elbow Surg. 2005;14:79S-83S pubmed
    ..Future studies will further evaluate the mechanisms of the disease process as well as potential targeted treatment modalities. ..
  11. Juul Kristensen B, Jensen C. Self-reported workplace related ergonomic conditions as prognostic factors for musculoskeletal symptoms: the "BIT" follow up study on office workers. Occup Environ Med. 2005;62:188-94 pubmed
    ..To identify prognostic ergonomic and work technique factors for musculoskeletal symptoms among office workers and in a subgroup with highly monotonous repetitive computer work...
  12. Speklé E, Hoozemans M, Blatter B, Heinrich J, van der Beek A, Knol D, et al. Effectiveness of a questionnaire based intervention programme on the prevalence of arm, shoulder and neck symptoms, risk factors and sick leave in computer workers: a cluster randomised controlled trial in an occupational setting. BMC Musculoskelet Disord. 2010;11:99 pubmed publisher
    ..The purpose of this study was to assess the effectiveness of this intervention programme...
  13. Elliott M, Barr A, Kietrys D, Al Shatti T, Amin M, Barbe M. Peripheral neuritis and increased spinal cord neurochemicals are induced in a model of repetitive motion injury with low force and repetition exposure. Brain Res. 2008;1218:103-13 pubmed publisher
    ..Thus, performance of even a low repetition, negligible force upper extremity task for 3 months can induce mild peripheral tissue inflammation, neurochemical increases in spinal cord dorsal horns, and declines in fine motor control...
  14. Barbe M, Barr A. Inflammation and the pathophysiology of work-related musculoskeletal disorders. Brain Behav Immun. 2006;20:423-9 pubmed
  15. Thomsen J, Gerr F, Atroshi I. Carpal tunnel syndrome and the use of computer mouse and keyboard: a systematic review. BMC Musculoskelet Disord. 2008;9:134 pubmed publisher
    ..This review examines evidence for an association between computer work and carpal tunnel syndrome (CTS)...
  16. Occhipinti E, Colombini D. Updating reference values and predictive models of the OCRA method in the risk assessment of work-related musculoskeletal disorders of the upper limbs. Ergonomics. 2007;50:1727-39 pubmed
  17. Carp S, Barbe M, Winter K, Amin M, Barr A. Inflammatory biomarkers increase with severity of upper-extremity overuse disorders. Clin Sci (Lond). 2007;112:305-14 pubmed
  18. Larsson B, Rosendal L, Kristiansen J, Sjøgaard G, Søgaard K, Ghafouri B, et al. Responses of algesic and metabolic substances to 8 h of repetitive manual work in myalgic human trapezius muscle. Pain. 2008;140:479-90 pubmed publisher
    ..In contrast, no sign of low blood flow or increased stress or muscle activity markers were found in TM...
  19. Szomor Z, Appleyard R, Murrell G. Overexpression of nitric oxide synthases in tendon overuse. J Orthop Res. 2006;24:80-6 pubmed
    ..This study is the first to show that NOS isoforms are upregulated in rotator cuff tendon as a result of chronic overuse, and suggests the involvement of nitric oxide in the response of tendon tissue to increased mechanical stress...
  20. Coq J, Barr A, Strata F, Russier M, Kietrys D, Merzenich M, et al. Peripheral and central changes combine to induce motor behavioral deficits in a moderate repetition task. Exp Neurol. 2009;220:234-45 pubmed publisher
    ..This study provides strong evidence that both peripheral inflammation and cortical neuroplasticity jointly contribute to the development of chronic repetitive motion disorders...
  21. Rani S, Barbe M, Barr A, Litvin J. Periostin-like-factor and Periostin in an animal model of work-related musculoskeletal disorder. Bone. 2009;44:502-12 pubmed publisher
    ..In general, the data suggest that PLF is located in tissues during the early adaptive stage of remodeling but not during the pathological phase and therefore might be a marker of early adaptive remodeling...
  22. Tjepkema M. Repetitive strain injury. Health Rep. 2003;14:11-30 pubmed
    ..This article describes the characteristics of people who report a repetitive strain injury (RSI) and examines the association of an RSI with chronic pain and with psychological distress...
  23. Alexopoulos E, Stathi I, Charizani F. Prevalence of musculoskeletal disorders in dentists. BMC Musculoskelet Disord. 2004;5:16 pubmed
    ..The aim of this study was to investigate the relations between physical, psychosocial, and individual characteristics and different endpoints of musculoskeletal complaints of low back, neck, shoulders and hand/wrist...
  24. Lassen C, Mikkelsen S, Kryger A, Brandt L, Overgaard E, Thomsen J, et al. Elbow and wrist/hand symptoms among 6,943 computer operators: a 1-year follow-up study (the NUDATA study). Am J Ind Med. 2004;46:521-33 pubmed
    ..The aim of this study was to examine relations between computer work aspects and elbow and wrist/hand pain conditions and disorders...
  25. Barbe M, Elliott M, Abdelmagid S, Amin M, Popoff S, Safadi F, et al. Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasks. J Orthop Res. 2008;26:1320-6 pubmed publisher
    ..Thus, several tissue and circulating cytokines/chemokines increase in an exposure dependent manner following short-term performance of repetitive reaching tasks and correlate with macrophage infiltration and decreasing grip strength...
  26. Shafer Crane G. Repetitive stress and strain injuries: preventive exercises for the musician. Phys Med Rehabil Clin N Am. 2006;17:827-42 pubmed
    ..More studies are needed to provide evidence for effective treatment and prevention of RSI...
  27. van Rijn R, Huisstede B, Koes B, Burdorf A. Associations between work-related factors and the carpal tunnel syndrome--a systematic review. Scand J Work Environ Health. 2009;35:19-36 pubmed
    ..The aim of this study was to make a quantitative assessment of the exposure-response relationships between work-related physical and psychosocial factors and the occurrence of carpal tunnel syndrome (CTS) in occupational populations...
  28. van Eijsden Besseling M, Peeters F, Reijnen J, de Bie R. Perfectionism and coping strategies as risk factors for the development of non-specific work-related upper limb disorders (WRULD). Occup Med (Lond). 2004;54:122-7 pubmed
    ..It also appeared that non-specific WRULD was more likely to develop in patients with neurotic-perfectionist personalities...
  29. Cole D, Ibrahim S, Shannon H. Predictors of work-related repetitive strain injuries in a population cohort. Am J Public Health. 2005;95:1233-7 pubmed
    ..We assessed predictors of work-related repetitive strain injuries using data from 4 waves of the Canadian National Population Health Survey...
  30. Roman Liu D. Repetitive task indicator as a tool for assessment of upper limb musculoskeletal load induced by repetitive task. Ergonomics. 2007;50:1740-60 pubmed
    ..Thus, this analysis indicates that the proposed RTI reflects well the upper limb load occurring as a result of performing repetitive work...
  31. Millar N, Wei A, Molloy T, Bonar F, Murrell G. Heat shock protein and apoptosis in supraspinatus tendinopathy. Clin Orthop Relat Res. 2008;466:1569-76 pubmed publisher
    ..This finding suggests heat shock proteins play a role in the cascade of stress-activated programmed cell death and degeneration in tendinopathy and may provide a novel target in preventing tendinopathies...
  32. Elliott M, Barr A, Barbe M. Spinal substance P and neurokinin-1 increase with high repetition reaching. Neurosci Lett. 2009;454:33-7 pubmed publisher
    ..85, p<0.001 and r=0.88, p<0.001, respectively). Thus, our highly repetitive task leads to increased spinal cord pro-nociceptive neurochemicals that are most likely directed by forelimb muscle inflammation and pain...
  33. Rani S, Barbe M, Barr A, Litvin J. Induction of periostin-like factor and periostin in forearm muscle, tendon, and nerve in an animal model of work-related musculoskeletal disorder. J Histochem Cytochem. 2009;57:1061-73 pubmed publisher
    ..Periostin, on the other hand, was not present in satellite cells and/or myoblasts...
  34. Leclerc A, Chastang J, Niedhammer I, Landre M, Roquelaure Y. Incidence of shoulder pain in repetitive work. Occup Environ Med. 2004;61:39-44 pubmed
    ..To determine the predictiveness of personal and occupational factors for the onset of shoulder pain in occupations requiring repetitive work...
  35. Nieradko B, Borzecki A. Computer use and computer related repetitive strain injuries among students of the Medical University of Lublin. Ann Univ Mariae Curie Sklodowska Med. 2003;58:354-7 pubmed
    ..Even though they do not spend too long hours using their PCs, most of them doing it for one hour daily, they complain about eye and vertebral column strain symptoms...
  36. Barr A, Barbe M, Clark B. Work-related musculoskeletal disorders of the hand and wrist: epidemiology, pathophysiology, and sensorimotor changes. J Orthop Sports Phys Ther. 2004;34:610-27 pubmed
    ..Clinicians should consider all of these pathomechanisms when examining and treating patients with hand/wrist WMSDs...
  37. Sluiter J, Frings Dresen M. Quality of life and illness perception in working and sick-listed chronic RSI patients. Int Arch Occup Environ Health. 2008;81:495-501 pubmed
    ..To study differences between working and sick-listed chronic repetitive strain injury (RSI) patients in the Netherlands with respect to indices of quality of life and illness perception...
  38. Gerr F, Monteilh C, Marcus M. Keyboard use and musculoskeletal outcomes among computer users. J Occup Rehabil. 2006;16:265-77 pubmed
  39. Verhagen A, Karels C, Bierma Zeinstra S, Burdorf L, Feleus A, Dahaghin S, et al. Ergonomic and physiotherapeutic interventions for treating work-related complaints of the arm, neck or shoulder in adults. Cochrane Database Syst Rev. 2006;:CD003471 pubmed
    ..Conservative interventions such as physiotherapy and ergonomic adjustments (such as keyboard adjustments or ergonomic advice) play a major role in the treatment of most work-related complaints of the arm, neck or shoulder (CANS)...
  40. Roman Liu D. Upper limb load as a function of repetitive task parameters: part 1--a model of upper limb load. Int J Occup Saf Ergon. 2005;11:93-102 pubmed
    ..A comparison of ICL, which expresses external load with a physiological indicator of upper limb load, is presented in Part 2 of the paper...
  41. Al Shatti T, Barr A, Safadi F, Amin M, Barbe M. Increase in inflammatory cytokines in median nerves in a rat model of repetitive motion injury. J Neuroimmunol. 2005;167:13-22 pubmed
    ..Cytokine sources included Schwann cells, fibroblasts and phagocytic macrophages (ED1-immunopositive). These findings suggest that cytokines are involved in the pathophysiology of repetitive motion injuries in peripheral nerves...
  42. Zapata A, Moraes A, Leone C, Doria Filho U, Silva C. Pain and musculoskeletal pain syndromes related to computer and video game use in adolescents. Eur J Pediatr. 2006;165:408-14 pubmed
    ..Despite the frequent use of computer and video games among adolescents, this was not associated with the presence of pain and musculoskeletal pain syndromes...
  43. Barr A, Barbe M, Clark B. Systemic inflammatory mediators contribute to widespread effects in work-related musculoskeletal disorders. Exerc Sport Sci Rev. 2004;32:135-42 pubmed
    ..A systemic inflammatory component may affect tissues not directly involved in task performance, thereby contributing to widespread and puzzling symptoms that are often characteristic of patients with WMSDs...
  44. Fedorczyk J, Barr A, Rani S, Gao H, Amin M, Amin S, et al. Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury. J Orthop Res. 2010;28:298-307 pubmed publisher
  45. Archambault J, Jelinsky S, Lake S, Hill A, Glaser D, Soslowsky L. Rat supraspinatus tendon expresses cartilage markers with overuse. J Orthop Res. 2007;25:617-24 pubmed
  46. Asundi K, Rempel D. MMP-1, IL-1beta, and COX-2 mRNA expression is modulated by static load in rabbit flexor tendons. Ann Biomed Eng. 2008;36:237-43 pubmed publisher
    ..The correlation between creep and expression suggests that the pathway for MMP-1 and IL-1beta expression, leading eventually to tendon degeneration, may be regulated by the biomechanical factor creep...
  47. Turhan N, Akat C, Akyuz M, Cakci A. Ergonomic risk factors for cumulative trauma disorders in VDU operators. Int J Occup Saf Ergon. 2008;14:417-22 pubmed
    The objectives of this study were to investigate the rate of cumulative trauma disorders (CTDs) in the upper body and to describe the associations of such disorders with ergonomic parameters in a group of data entry operators...
  48. Bernaards C, Ariëns G, Hildebrandt V. The (cost-)effectiveness of a lifestyle physical activity intervention in addition to a work style intervention on the recovery from neck and upper limb symptoms in computer workers. BMC Musculoskelet Disord. 2006;7:80 pubmed
    ..A combined approach targeting work style and lifestyle physical activity seems promising, but little is known on the effectiveness of such combined interventions...
  49. Kee D, Karwowski W. A comparison of three observational techniques for assessing postural loads in industry. Int J Occup Saf Ergon. 2007;13:3-14 pubmed
    ..2%. These results showed that compared to RULA, OWAS, and REBA generally underestimated postural loads for the analyzed postures, irrespective of industry, work type, and whether or not the body postures were in a balanced state...
  50. IJmker S, Leijssen J, Blatter B, van der Beek A, van Mechelen W, Bongers P. Test-retest reliability and validity of self-reported duration of computer use at work. Scand J Work Environ Health. 2008;34:113-9 pubmed
    ..The aims of this study were to evaluate the test-retest reliability and the validity of self-reported duration of computer use at work...
  51. Szeto G, Straker L, O Sullivan P. A comparison of symptomatic and asymptomatic office workers performing monotonous keyboard work--1: neck and shoulder muscle recruitment patterns. Man Ther. 2005;10:270-80 pubmed
    ..These findings indicate that altered muscle recruitment patterns observed in the symptomatic subjects preceded the onset of task discomfort, and this finding may have important implications for the etiology of WRNULD...
  52. Schlossberg E, Morrow S, Llosa A, Mamary E, Dietrich P, Rempel D. Upper extremity pain and computer use among engineering graduate students. Am J Ind Med. 2004;46:297-303 pubmed
    ..The objective of this study was to investigate risk factors associated with persistent or recurrent upper extremity and neck pain among engineering graduate students...
  53. Hamilton A, Jacobs K, Orsmond G. The prevalence of computer-related musculoskeletal complaints in female college students. Work. 2005;24:387-94 pubmed
  54. Greening J, Dilley A, Lynn B. In vivo study of nerve movement and mechanosensitivity of the median nerve in whiplash and non-specific arm pain patients. Pain. 2005;115:248-53 pubmed
    ..e. painful responses to median nerve trunk and brachial plexus pressure and stretch) were apparent in both patients groups. Change in nerve tension and neural mechanosensitivity may contribute to symptoms in whiplash and NSAP patients...
  55. Banerjee P, Gangopadhyay S. A study on the prevalence of upper extremity repetitive strain injuries among the handloom weavers of West Bengal. J Hum Ergol (Tokyo). 2003;32:17-22 pubmed
    ..These results suggested that highly repetitive works engaged for a long time could increase the intensity of the pain felt and would lead to repetitive strain injuries...
  56. Speklé E, Hoozemans M, van der Beek A, Blatter B, Bongers P, van Dieen J. Internal consistency, test-retest reliability and concurrent validity of a questionnaire on work-related exposure related to arm, shoulder and neck symptoms in computer workers. Ergonomics. 2009;52:1087-103 pubmed publisher
    ..The questionnaire can be used as a means to rapidly collect data on a large population of office workers and at low cost...
  57. Rani S, Barbe M, Barr A, Litivn J. Role of TNF alpha and PLF in bone remodeling in a rat model of repetitive reaching and grasping. J Cell Physiol. 2010;225:152-67 pubmed publisher
    ..Thus, tissue loading in vivo resulted in increased TNFalpha, which increased PLF, which then induced anabolic bone formation, the latter results confirmed in vitro...
  58. Scott A, Cook J, Hart D, Walker D, Duronio V, Khan K. Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats. Arthritis Rheum. 2007;56:871-81 pubmed
    ..To investigate tenocyte regulatory events during the development of overuse supraspinatus tendinosis in rats...
  59. Tsauo J, Lee H, Hsu J, Chen C, Chen C. Physical exercise and health education for neck and shoulder complaints among sedentary workers. J Rehabil Med. 2004;36:253-7 pubmed
    ..To assess the effectiveness of 3 different health promotion exercise programs for work-related shoulder and neck pain...
  60. Sun H, Li Y, Fung D, Majeska R, Schaffler M, Flatow E. Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage. Clin Orthop Relat Res. 2008;466:1555-61 pubmed publisher
    ..The data also suggest MMP-13 is regulated by both IL-1beta-dependent and IL-1beta-independent pathways...