smoke inhalation injury

Summary

Summary: Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.

Top Publications

  1. Enkhbaatar P, Cox R, Traber L, Westphal M, Aimalohi E, Morita N, et al. Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation. Crit Care Med. 2007;35:2805-10 pubmed
    ..the hypothesis that aerosolized anticoagulants will reduce the degree of airway obstruction and improve pulmonary function in sheep with severe combined burn and smoke inhalation injury by preventing the formation of airway fibrin clots.
  2. Park G, Park J, Jeong D, Jeong S. Prolonged airway and systemic inflammatory reactions after smoke inhalation. Chest. 2003;123:475-80 pubmed
    ..This study investigated the long-term effects of smoke inhalation, by examining airway responsiveness, airway inflammation, and systemic effects...
  3. Miller A, Rivero A, Ziad S, Smith D, Elamin E. Influence of nebulized unfractionated heparin and N-acetylcysteine in acute lung injury after smoke inhalation injury. J Burn Care Res. 2009;30:249-56 pubmed publisher
    ..and N-acetylcystine reduces 28-days mortality and lung injury scores (LISs) in adult patients with smoke inhalation injury requiring mechanical ventilation...
  4. Cancio L. Airway management and smoke inhalation injury in the burn patient. Clin Plast Surg. 2009;36:555-67 pubmed publisher
    b>Smoke inhalation injury, a unique form of acute lung injury, greatly increases the occurrence of postburn morbidity and mortality...
  5. Quinn D, Moufarrej R, Volokhov A, Syrkina O, Hales C. Combined smoke inhalation and scald burn in the rat. J Burn Care Rehabil. 2003;24:208-16 pubmed
    ..Only in combined smoke and burn was there a drop in cardiac output and stroke volume with pulmonary edema and lung neutrophil influx...
  6. Syrkina O, Quinn D, Jung W, Ouyang B, Hales C. Inhibition of JNK activation prolongs survival after smoke inhalation from fires. Am J Physiol Lung Cell Mol Physiol. 2007;292:L984-91 pubmed
    ..05). These in vivo data show that the JNK pathway plays a critical role in smoke-induced lung injury and offer an attractive therapeutic approach for this injury...
  7. Sterner J, Zanders T, Morris M, Cancio L. Inflammatory mediators in smoke inhalation injury. Inflamm Allergy Drug Targets. 2009;8:63-9 pubmed
    ..and improving outcomes from burn injuries, the pathophysiology and inflammatory processes involved in smoke inhalation injury has been extensively investigated in animal models...
  8. Thompson J, Molnar J, Hines M, Chang M, Pranikoff T. Successful management of adult smoke inhalation with extracorporeal membrane oxygenation. J Burn Care Rehabil. 2005;26:62-6 pubmed
    ..Both patients were discharged home shortly afterwards and have managed well. ECMO should be considered when patients are facing a respiratory death from inhalation injury on conventional mechanical ventilation...
  9. Jonkam C, Zhu Y, Jacob S, Rehberg S, Kraft E, Hamahata A, et al. Muscarinic receptor antagonist therapy improves acute pulmonary dysfunction after smoke inhalation injury in sheep. Crit Care Med. 2010;38:2339-44 pubmed publisher

More Information

Publications62

  1. Enkhbaatar P, Murakami K, Shimoda K, Salsbury J, Cox R, Hawkins H, et al. Ketorolac attenuates cardiopulmonary derangements in sheep with combined burn and smoke inhalation injury. Clin Sci (Lond). 2003;105:621-8 pubmed
    ..These results suggest that ketorolac may ameliorate cardiopulmonary morbidity, at least in part, by inhibiting excessive NO...
  2. Lawson Smith P, Jansen E, Hilsted L, Hyldegaard O. Effect of hyperbaric oxygen therapy on whole blood cyanide concentrations in carbon monoxide intoxicated patients from fire accidents. Scand J Trauma Resusc Emerg Med. 2010;18:32 pubmed publisher
  3. Nelson J, Cairns B, Charles A. Early extracorporeal life support as rescue therapy for severe acute respiratory distress syndrome after inhalation injury. J Burn Care Res. 2009;30:1035-8 pubmed publisher
    ..We report a case of a 22-year-old man with Down syndrome who presented with isolated fire-induced smoke inhalation injury. He sustained no cutaneous burns...
  4. Cox R, Burke A, Soejima K, Murakami K, Katahira J, Traber L, et al. Airway obstruction in sheep with burn and smoke inhalation injuries. Am J Respir Cell Mol Biol. 2003;29:295-302 pubmed
    ..results suggest that strategies to remove or decrease formation of upper airway obstructive material may reduce its deposition into small airways and parenchyma and may improve respiratory function in victims of smoke inhalation injury.
  5. Lee H, Greeley G, Herndon D, Sinha M, Luxon B, Englander E. A rat model of smoke inhalation injury: influence of combustion smoke on gene expression in the brain. Toxicol Appl Pharmacol. 2005;208:255-65 pubmed
    ..Thus, the new rat model, in combination with microarray analyses, affords insight into the complex molecular pathophysiology of smoke inhalation in the brain...
  6. Edelman D, Khan N, Kempf K, White M. Pneumonia after inhalation injury. J Burn Care Res. 2007;28:241-6 pubmed
    ..Admission carboxyhemoglobin levels, age, and sex had no relationship to the development of pneumonia. An increase in TBSA burn was associated with a higher pneumonia rate...
  7. Hamahata A, Enkhbaatar P, Sakurai H, Nozaki M, Traber D. Effect of ablated bronchial blood flow on survival rate and pulmonary function after burn and smoke inhalation in sheep. Burns. 2009;35:802-10 pubmed publisher
    ..Ablated bronchial circulation attenuated these pathophysiological changes...
  8. Lange M, Hamahata A, Traber D, Cox R, Kulp G, Nakano Y, et al. Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury. Crit Care Med. 2011;39:718-24 pubmed publisher
  9. Cartotto R, Walia G, Ellis S, Fowler R. Oscillation after inhalation: high frequency oscillatory ventilation in burn patients with the acute respiratory distress syndrome and co-existing smoke inhalation injury. J Burn Care Res. 2009;30:119-27 pubmed publisher
    ..Ventilation (HFOV) in burn patients with the Acute Respiratory Distress Syndrome (ARDS) who have had a smoke inhalation injury, and to compare with those without an inhalation injury...
  10. O Brien D, Walsh D, Terriff C, Hall A. Empiric management of cyanide toxicity associated with smoke inhalation. Prehosp Disaster Med. 2011;26:374-82 pubmed publisher
  11. Lee J, Mukai D, Kreuter K, Mahon S, Tromberg B, Brenner M. Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatments. Ann Emerg Med. 2007;49:802-5 pubmed
  12. Perng D, Chang T, Wang J, Lee C, Lu S, Shyue S, et al. Inflammatory role of AMP-activated protein kinase signaling in an experimental model of toxic smoke inhalation injury. Crit Care Med. 2013;41:120-32 pubmed publisher
    The molecular mechanisms underlying lung inflammation in toxic smoke inhalation injury are unknown...
  13. Alarie Y. Toxicity of fire smoke. Crit Rev Toxicol. 2002;32:259-89 pubmed
    ..Its role is minor, if any, but the data available on ethanol in brain tissue and blood of fire victims confirmed that brain ethanol level is an excellent predictor of blood ethanol...
  14. Madnani D, Steele N, de Vries E. Factors that predict the need for intubation in patients with smoke inhalation injury. Ear Nose Throat J. 2006;85:278-80 pubmed
    ..a retrospective chart review to identify predictors of respiratory distress in patients who present with smoke inhalation injury. Our study involved 41 patients who had been treated in the emergency room at a regional burn center...
  15. Maybauer D, Maybauer M, Traber L, Westphal M, Nakano Y, Enkhbaatar P, et al. Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep. Shock. 2006;26:489-95 pubmed
    ..on global and regional microvascular blood flow (RMBF) in an ovine model of septic shock after severe smoke inhalation injury. Sixteen sheep were randomized into two groups, a control group (no injury, n = 8) and a smoke/sepsis (SS)..
  16. Fortin J, Giocanti J, Ruttimann M, Kowalski J. Prehospital administration of hydroxocobalamin for smoke inhalation-associated cyanide poisoning: 8 years of experience in the Paris Fire Brigade. Clin Toxicol (Phila). 2006;44 Suppl 1:37-44 pubmed
    ..This article reports the results of a retrospective study of 8 years of experience of the Paris Fire Brigade with the prehospital use of hydroxocobalamin...
  17. Hall J, Hunt J, Arnoldo B, Purdue G. Use of high-frequency percussive ventilation in inhalation injuries. J Burn Care Res. 2007;28:396-400 pubmed
    ..a ventilatory modality promoted to rapidly remove airway secretions and improve survival of patients with smoke inhalation injury. From 1997 to 2005, a total of 92 patients with inhalation injury were treated with HFPV...
  18. Lin C, Liem A, Wu C, Wu Y, Yang J, Feng C. Severity score for predicting pneumonia in inhalation injury patients. Burns. 2012;38:203-7 pubmed publisher
    ..The impact of these risk factors should be validated in further prospective trials to improve outcome or at least reduce the incidence of the surrogate diagnosis of pneumonia...
  19. Mosier M, Pham T, Park D, Simmons J, Klein M, Gibran N. Predictive value of bronchoscopy in assessing the severity of inhalation injury. J Burn Care Res. 2012;33:65-73 pubmed publisher
    ..Prospective studies should definitively answer whether AIS bronchoscopy staging predicts hospitalization outcomes in inhalation injury...
  20. Erdman A. Is hydroxocobalamin safe and effective for smoke inhalation? Searching for guidance in the haze. Ann Emerg Med. 2007;49:814-6 pubmed
  21. Enkhbaatar P, Murakami K, Cox R, Westphal M, Morita N, Brantley K, et al. Aerosolized tissue plasminogen inhibitor improves pulmonary function in sheep with burn and smoke inhalation. Shock. 2004;22:70-5 pubmed
    ..activator, which lyses fibrin clots, on acute lung injury in sheep that had undergone combined burn/smoke inhalation injury. Anesthetized sheep were given a 40% total body surface, third degree burn and were insufflated with ..
  22. Jones S, Short K, Hanson W, Hendrix L, Charles A, Cairns B. Evaluation of a new circuit configuration for the VDR-4 high-frequency percussive ventilator. J Burn Care Res. 2010;31:640-5 pubmed publisher
    ..This new VDR-4 circuit configuration may have an important impact on patient safety...
  23. Nakano Y, Maybauer M, Maybauer D, Enkhbaatar P, Traber D. A novel antibiotic based long-term model of ovine smoke inhalation injury and septic shock. Burns. 2010;36:1050-8 pubmed publisher
    We modified our established and clinically relevant ARDS model of smoke inhalation injury and septic shock by administration of combined antibiotics (AB) such as piperacillin and ciprofloxacin, to more closely mimic the clinical ..
  24. Maybauer M, Rehberg S, Traber D, Herndon D, Maybauer D. [Pathophysiology of acute lung injury in severe burn and smoke inhalation injury]. Anaesthesist. 2009;58:805-12 pubmed publisher
    ..Current data suggest that cytotoxins and activated cells are formed in the airway and carried to the parenchyma...
  25. Qi S, Sun W. The effects of inhaled nitric oxide on cardiac pathology and energy metabolism in a canine model of smoke inhalation injury. Burns. 2004;30:65-71 pubmed
    The effects of inhaled nitric oxide (NO) on cardiac pathology and energy metabolism were studied in a canine model of smoke inhalation injury.
  26. Carr J, Phillips B, Bowling W. The utility of bronchoscopy after inhalation injury complicated by pneumonia in burn patients: results from the National Burn Repository. J Burn Care Res. 2009;30:967-74 pubmed publisher
    ..In addition, there was a trend toward an improvement in mortality. The aggressive use of bronchoscopy after inhalation injury may be justified...
  27. Colohan S. Predicting prognosis in thermal burns with associated inhalational injury: a systematic review of prognostic factors in adult burn victims. J Burn Care Res. 2010;31:529-39 pubmed publisher
    ..It seems that %TBSA, presence of IHT, and age are the best predictors of mortality among the current published literature on burn prognosis...
  28. Dacey M. Tragedy and response- the Rhode Island nightclub fire. N Engl J Med. 2003;349:1990-2 pubmed
  29. Morita N, Enkhbaatar P, Maybauer D, Maybauer M, Westphal M, Murakami K, et al. Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep. Burns. 2011;37:465-73 pubmed publisher
    ..We hypothesized reduction of bronchial blood flow reduces exudation to the airway and ameliorates lung injury from combined burn and smoke insults (B&S injury)...
  30. Asmussen S, Maybauer D, Fraser J, Jennings K, George S, Keiralla A, et al. Extracorporeal membrane oxygenation in burn and smoke inhalation injury. Burns. 2013;39:429-35 pubmed publisher
    ..of extracorporeal membrane oxygenation (ECMO) in hypoxemic respiratory failure resulting from burn and smoke inhalation injury. We searched any article published before March 01, 2012...
  31. Westphal M, Noshima S, Isago T, Fujioka K, Maybauer M, Maybauer D, et al. Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury. Anesthesiology. 2005;102:954-61 pubmed
    ..in the pathophysiology of acute lung injury, the aim of this study was to evaluate the effects of selective thromboxane A2 synthase inhibition on cardiopulmonary function in the experimental setting of severe smoke inhalation injury.
  32. Holt J, Saffle J, Morris S, Cochran A. Use of inhaled heparin/N-acetylcystine in inhalation injury: does it help?. J Burn Care Res. 2008;29:192-5 pubmed publisher
    ..Importantly, the use of AHA in adults with inhalation injury did not affect clinical outcomes. A prospective, randomized trial would be of benefit to delineate the clinical benefits of AHA treatment for inhalation injury...
  33. Tasaki O, Mozingo D, Dubick M, Goodwin C, Yantis L, Pruitt B. Effects of heparin and lisofylline on pulmonary function after smoke inhalation injury in an ovine model. Crit Care Med. 2002;30:637-43 pubmed
    ..This study evaluates the effects of heparin alone and in combination with lisofylline, 1-(5-R-hydroxyhexyl)3,7-dimethylxanthine, on severe smoke injury...
  34. Borron S, Baud F, Barriot P, Imbert M, Bismuth C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg Med. 2007;49:794-801, 801.e1-2 pubmed
    ..To assess outcomes in patients treated with hydroxocobalamin at the fire scene or in the ICU for suspected smoke inhalation-associated cyanide poisoning...
  35. Lawson Smith P, Jansen E, Hyldegaard O. Cyanide intoxication as part of smoke inhalation--a review on diagnosis and treatment from the emergency perspective. Scand J Trauma Resusc Emerg Med. 2011;19:14 pubmed publisher
    ..A specific antidote is hydroxycobalamin, which can be given iv. and has few side effects...
  36. Maybauer M, Maybauer D, Traber L, Westphal M, Enkhbaatar P, Morita N, et al. Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury. Shock. 2005;24:226-31 pubmed
  37. Enkhbaatar P, Kikuchi Y, Traber L, Westphal M, Morita N, Maybauer M, et al. Effect of inhaled nitric oxide on pulmonary vascular hyperpermeability in sheep following smoke inhalation. Burns. 2005;31:1013-9 pubmed
    ..Nitric oxide inhalation ameliorated the above-mentioned pathological changes. The results suggest that nitric oxide inhalation has potential for beneficial effect in the treatment of patients suffering from smoke inhalation...
  38. Lange M, Hamahata A, Traber D, Esechie A, Jonkam C, Bansal K, et al. A murine model of sepsis following smoke inhalation injury. Biochem Biophys Res Commun. 2010;391:1555-60 pubmed publisher
    ..In mice receiving only smoke inhalation injury, no systemic cytokine release and increased lung tissue lipid peroxidation were observed...
  39. Murakami K, Traber D. Pathophysiological basis of smoke inhalation injury. News Physiol Sci. 2003;18:125-9 pubmed
    b>Smoke inhalation injury results in serious respiratory failure. When smoke inhalation injury is combined with burn injury or pneumonia, the physiological responses are different and more severe than those of smoke inhalation injury alone...
  40. Eckstein M, Maniscalco P. Focus on smoke inhalation--the most common cause of acute cyanide poisoning. Prehosp Disaster Med. 2006;21:s49-55 pubmed
  41. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, Traber L, Phillips G, et al. Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury. Am J Physiol Heart Circ Physiol. 2003;285:H2430-6 pubmed
    ..The results identify a major role for iNOS in mediating extrapulmonary comorbidity in a clinically relevant and severe trauma model and support the use of highly selective iNOS inhibitors as novel treatments in critical care medicine...
  42. Mosier M, Gamelli R, Halerz M, Silver G. Microbial contamination in burn patients undergoing urgent intubation as part of their early airway management. J Burn Care Res. 2008;29:304-10 pubmed publisher
    ..Further studies with a larger patient population and randomization to treatment and nontreatment of the BAL culture results may show statistically significant differences in ventilator days, length of stay, and mortality...
  43. Jones S, Short K, Joseph M, Sommer C, Cairns B. Use of a new novel humidification system with high frequency percussive ventilation in a patient with inhalation injury. J Burn Care Res. 2010;31:499-502 pubmed publisher
    ..This new device may alleviate previous concerns related to the delivery of adequate humidification with the HFPV. This case report was approved by the University of North Carolina School of Medicine Institutional Review Board...
  44. Morita N, Traber M, Enkhbaatar P, Westphal M, Murakami K, Leonard S, et al. Aerosolized alpha-tocopherol ameliorates acute lung injury following combined burn and smoke inhalation injury in sheep. Shock. 2006;25:277-82 pubmed
    ..Vitamin E nebulization therapy improved the clinical responses to burn and smoke inhalation-induced acute lung injury...
  45. Allan P, Osborn E, Chung K, Wanek S. High-frequency percussive ventilation revisited. J Burn Care Res. 2010;31:510-20 pubmed publisher
    ..This article will discuss the clinically pertinent aspects of HFPV, inclusive of high- and low-frequency ventilation...
  46. Cox R, Mlcak R, Chinkes D, Jacob S, Enkhbaatar P, Jaso J, et al. Upper airway mucus deposition in lung tissue of burn trauma victims. Shock. 2008;29:356-61 pubmed
    ..Increased mucus synthesis and/or impaired mucociliary function may contribute to the pulmonary pathophysiology associated with burn injury...
  47. Hamahata A, Enkhbaatar P, Kraft E, Lange M, Leonard S, Traber M, et al. gamma-Tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury. Free Radic Biol Med. 2008;45:425-33 pubmed publisher
    ..Pulmonary gT delivery along with a FO source may be a novel effective treatment strategy in management of patients with acute lung injury...
  48. Palmieri T. Inhalation injury: research progress and needs. J Burn Care Res. 2007;28:549-54 pubmed
  49. Cha S, Kim C, Lee J, Park J, Jung T, Choi W, et al. Isolated smoke inhalation injuries: acute respiratory dysfunction, clinical outcomes, and short-term evolution of pulmonary functions with the effects of steroids. Burns. 2007;33:200-8 pubmed
    ..The improvement of pulmonary functions progressed primarily within the first 3 months, whereas short-course steroid therapy exerted no influence on the eventual recovery of pulmonary functions in the less severe cases...
  50. Endorf F, Gamelli R. Inhalation injury, pulmonary perturbations, and fluid resuscitation. J Burn Care Res. 2007;28:80-3 pubmed
    ..However, the P:F ratio may be a more accurate predictor of increased fluid requirements during the acute resuscitation...
  51. Hamahata A, Enkhbaatar P, Sakurai H, Nozaki M, Traber D. Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine model. Burns. 2010;36:1042-9 pubmed publisher
    ..We hypothesized that sclerosis of the bronchial artery after insult attenuates smoke/burn-induced acute lung injury...
  52. Davis C, Albright J, Carter S, Ramirez L, Kim H, Gamelli R, et al. Early pulmonary immune hyporesponsiveness is associated with mortality after burn and smoke inhalation injury. J Burn Care Res. 2012;33:26-35 pubmed publisher
    ..This study demonstrates that the early pulmonary immune response to burn and smoke inhalation may be attenuated in patients who succumb to their injuries...
  53. Oh J, Chung K, Allen A, Batchinsky A, Huzar T, King B, et al. Admission chest CT complements fiberoptic bronchoscopy in prediction of adverse outcomes in thermally injured patients. J Burn Care Res. 2012;33:532-8 pubmed publisher
    ..7-fold increase in the incidence of the composite endpoint. Admission CT assists in predicting future lung dysfunction in burn patients...