wounds and injuries

Summary

Summary: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.

Top Publications

  1. Cap A, Spinella P, Borgman M, Blackbourne L, Perkins J. Timing and location of blood product transfusion and outcomes in massively transfused combat casualties. J Trauma Acute Care Surg. 2012;73:S89-94 pubmed publisher
    ..Mortality outcomes associated with early (first 6 hours) resuscitation incorporating platelets, for combat casualties requiring MT, have not been reported...
  2. Bradburn E, Rogers F, Krasne M, Rogers A, Horst M, Beelen M, et al. High-risk geriatric protocol: improving mortality in the elderly. J Trauma Acute Care Surg. 2012;73:435-40 pubmed publisher
    ..We have developed the high-risk geriatric protocol (GP) that seeks to identify high-risk geriatric patients. We hypothesized that a high-risk GP would improve outcome in this select group of patients...
  3. Sheets L, Leach M, Koszewski I, Lessmeier A, Nugent M, Simpson P. Sentinel injuries in infants evaluated for child physical abuse. Pediatrics. 2013;131:701-7 pubmed publisher
    ..Relatively minor abusive injuries can precede severe physical abuse in infants. Our objective was to determine how often abused infants have a previous history of "sentinel" injuries, compared with infants who were not abused...
  4. Harr J, Moore E, Ghasabyan A, Chin T, Sauaia A, Banerjee A, et al. Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock. 2013;39:45-9 pubmed publisher
    ..These data suggest that fibrinogen should be addressed early in trauma patients manifesting acute coagulopathy of trauma...
  5. Hesselfeldt R, Steinmetz J, Jans H, Jacobsson M, Andersen D, Buggeskov K, et al. Impact of a physician-staffed helicopter on a regional trauma system: a prospective, controlled, observational study. Acta Anaesthesiol Scand. 2013;57:660-8 pubmed publisher
    ..Our hypothesis was that PS-HEMS would reduce time from injury to definitive care for severely injured patients...
  6. Schmertmann M, Williamson A, Black D. Leading causes of injury hospitalisation in children aged 0-4 years in New South Wales by injury submechanism: a brief profile by age and sex. J Paediatr Child Health. 2012;48:978-84 pubmed publisher
    ..To identify the leading causes of injury in children aged 0-4 years by single year of age using injury submechanisms and present a brief epidemiologic profile of each cause...
  7. Frith D, Brohi K. The pathophysiology of trauma-induced coagulopathy. Curr Opin Crit Care. 2012;18:631-6 pubmed publisher
    ..This review will collate and assimilate the most recent data about TIC in order to present our state-of-the-art understanding of this condition...
  8. Fergusson D, Boden J, Horwood L. Nine-year follow-up of a home-visitation program: a randomized trial. Pediatrics. 2013;131:297-303 pubmed publisher
    ..To evaluate the extent to which a home-visitation program (Early Start) had benefits for child abuse, child behavior, and parental- and family-level benefits to the 9-year follow-up...
  9. Roberts I, Perel P, Prieto Merino D, Shakur H, Coats T, Hunt B, et al. Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ. 2012;345:e5839 pubmed publisher
    ..To assess the extent to which current protocols for treatment with tranexamic acid maximise benefits to patients...

Scientific Experts

More Information

Publications62

  1. Curtis K, Mitchell R, Chong S, Balogh Z, Reed D, Clark P, et al. Injury trends and mortality in adult patients with major trauma in New South Wales. Med J Aust. 2012;197:233-7 pubmed
    ..To examine trends in mechanism and outcome of major traumatic injury in adults since the implementation of the New South Wales trauma monitoring program, and to identify factors associated with mortality...
  2. Ringdal K, Skaga N, Hestnes M, Steen P, Røislien J, Rehn M, et al. Abbreviated Injury Scale: not a reliable basis for summation of injury severity in trauma facilities?. Injury. 2013;44:691-9 pubmed publisher
    ..European trauma registries recommended the AIS 2008 edition, but the levels of inter-rater agreement and reliability of ISS and NISS, associated with its use, have not been reported...
  3. Foltran F, Avossa F, Fedeli U, Baldi I, Spolaore P, Gregori D. Seasonal variations in injury rates in children: evidence from a 10-year study in the Veneto Region, Italy. Int J Inj Contr Saf Promot. 2013;20:254-8 pubmed publisher
    ..8 for minor injuries to 2.0 for severe injuries (p <0.001). The observed pattern of increased admission in the summer months should guide resource planning and implementation of preventive strategies. ..
  4. Rogers A, Rogers F, Bradburn E, Krasne M, Lee J, Wu D, et al. Old and undertriaged: a lethal combination. Am Surg. 2012;78:711-5 pubmed
    ..UT has a high risk of death in elderly patients. Trauma triage guidelines need to be better tailored to identify the high-risk geriatric trauma patient...
  5. Johansson P, Sørensen A, Larsen C, Windeløv N, Stensballe J, Perner A, et al. Low hemorrhage-related mortality in trauma patients in a Level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets. Transfusion. 2013;53:3088-99 pubmed publisher
    ..Hemorrhage accounts for most preventable trauma deaths, but still the optimal strategy for hemostatic resuscitation remains debated...
  6. Jackson J, Kopecki Z, Adams D, Cowin A. Flii neutralizing antibodies improve wound healing in porcine preclinical studies. Wound Repair Regen. 2012;20:523-36 pubmed publisher
    ..The results show that treatment with FnAb accelerates reepithelialization and improves the macroscopic appearance of early scars. FnAbs have the potential to enhance wound repair and reduce scar formation...
  7. Ardolino A, Sleat G, Willett K. Outcome measurements in major trauma--results of a consensus meeting. Injury. 2012;43:1662-6 pubmed publisher
    ..At present, there are no established outcome indicators. As more patients survive major trauma, outcomes will need to be measured in terms of morbidity and not mortality alone...
  8. Tannvik T, Bakke H, Wisborg T. A systematic literature review on first aid provided by laypeople to trauma victims. Acta Anaesthesiol Scand. 2012;56:1222-7 pubmed publisher
    ..Due to great heterogeneity in the studies, firm conclusions can not be drawn. However, the results show a potential mortality reduction if first aid is administered to trauma victims. Further research is necessary to establish this...
  9. Perel P, Prieto Merino D, Shakur H, Clayton T, Lecky F, Bouamra O, et al. Predicting early death in patients with traumatic bleeding: development and validation of prognostic model. BMJ. 2012;345:e5166 pubmed publisher
    ..To develop and validate a prognostic model for early death in patients with traumatic bleeding...
  10. Forbes J, Fetterolf D. Dehydrated amniotic membrane allografts for the treatment of chronic wounds: a case series. J Wound Care. 2012;21:290, 292, 294-6 pubmed
    ..Dehydrated human amniotic membrane represents a potentially effective addition to existing wound care therapies, with further formal clinical studies indicated...
  11. Jayaraj R, Thomas M, Thomson V, Griffin C, Mayo L, Whitty M, et al. High risk alcohol-related trauma among the Aboriginal and Torres Strait Islanders in the Northern Territory. Subst Abuse Treat Prev Policy. 2012;7:33 pubmed publisher
    ..This review focuses on alcohol-related trauma in the Territory and draws attention to an urgent need for preventative health approach to address this critical issue...
  12. Kutcher M, Redick B, McCreery R, Crane I, Greenberg M, Cachola L, et al. Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg. 2012;73:13-9 pubmed publisher
    ..The increased morbidity and mortality associated with coagulopathy and thrombocytopenia after trauma are well described. However, few studies have assessed platelet function after injury...
  13. Morishita K, Aiboshi J, Kobayashi T, Mikami S, Yokoyama Y, Ogawa K, et al. Lipidomics analysis of mesenteric lymph after trauma and hemorrhagic shock. J Trauma Acute Care Surg. 2012;72:1541-7 pubmed publisher
    ..The purpose of this study was to identify the lipid mediators in PHSML and plasma by liquid chromatography/electrospray ionization mass spectrometry and then estimate the biologic activities of the identified lipids on PMNs...
  14. Deans K, Thackeray J, Askegard Giesmann J, Earley E, Groner J, Minneci P. Mortality increases with recurrent episodes of nonaccidental trauma in children. J Trauma Acute Care Surg. 2013;75:161-5 pubmed
  15. Derrett S, Samaranayaka A, Wilson S, Langley J, Ameratunga S, Cameron I, et al. Prevalence and predictors of sub-acute phase disability after injury among hospitalised and non-hospitalised groups: a longitudinal cohort study. PLoS ONE. 2012;7:e44909 pubmed publisher
    ..To date, few studies have investigated outcomes for both those who were hospitalised and those who were not...
  16. Dhondt S, Pirdavani A, Macharis C, Bellemans T, Putman K. Translating road safety into health outcomes using a quantitative impact assessment model. Inj Prev. 2012;18:413-20 pubmed publisher
    ..Therefore, both mortality and morbidity outcomes should be included in the evaluation of traffic safety policies. The authors propose a method to evaluate different policy options taking into account both fatalities and serious injuries...
  17. Hu M, Hu G, Sun Z, He X. Epidemiological survey of the prevalence of non-fatal injury among children aged 5-14 years in China. Biomed Environ Sci. 2012;25:407-12 pubmed publisher
    ..Medical treatment for one day was the main option for 80% of urban boys and girls, 84% of rural boys, and 72% of rural girls. Nonfatal injuries among children aged 5-14 years are a serious public health concern in China. ..
  18. Nagata T, Takamori A, Berg H, Hasselberg M. Comparing the impact of socio-demographic factors associated with traffic injury among older road users and the general population in Japan. BMC Public Health. 2012;12:887 pubmed publisher
    ..This study investigated the association between socio-demographic factors and traffic injury and traffic mortality for the general population and among older road users in Japan...
  19. Schöchl H, Schlimp C, Voelckel W. Potential value of pharmacological protocols in trauma. Curr Opin Anaesthesiol. 2013;26:221-9 pubmed publisher
    ..We summarize the concept of individualized, goal-directed coagulation management using coagulation factor concentrates...
  20. Young J, Utter G, Schermer C, Galante J, Phan H, Yang Y, et al. Saline versus Plasma-Lyte A in initial resuscitation of trauma patients: a randomized trial. Ann Surg. 2014;259:255-62 pubmed publisher
    ..We sought to compare resuscitation with 0.9% NaCl versus Plasma-Lyte A, a calcium-free balanced crystalloid solution, hypothesizing that Plasma-Lyte A would better correct the base deficit 24 hours after injury...
  21. Rodriguez Menocal L, Salgado M, Ford D, Van Badiavas E. Stimulation of skin and wound fibroblast migration by mesenchymal stem cells derived from normal donors and chronic wound patients. Stem Cells Transl Med. 2012;1:221-9 pubmed publisher
    ..These findings provide a foundation to develop therapies targeted specifically to the use of bone marrow-derived MSCs in wound healing and may provide insight into why some wounds do not heal...
  22. de Rome L, Boufous S, Georgeson T, Senserrick T, Richardson D, Ivers R. Bicycle crashes in different riding environments in the Australian capital territory. Traffic Inj Prev. 2014;15:81-8 pubmed publisher
    ..There is evidence that better cycling infrastructure increases participation, but whether it reduces the numbers of injured cyclists is less clear. This study examined injury outcomes of crashes in different cycling environments...
  23. Davenport R. Pathogenesis of acute traumatic coagulopathy. Transfusion. 2013;53 Suppl 1:23S-27S pubmed publisher
    ..TEG and ROTEM provide a rapid evaluation of clot dynamics in whole blood and are of greater value than coagulation screens in diagnosing and managing trauma hemorrhage...
  24. Thorson C, Ryan M, Van Haren R, Pereira R, Olloqui J, Otero C, et al. Change in hematocrit during trauma assessment predicts bleeding even with ongoing fluid resuscitation. Am Surg. 2013;79:398-406 pubmed
    ..Altogether, these results support the idea that fluid shifts are rapid after hemorrhage and Hct can be valuable during initial trauma assessment...
  25. Liu F, Yu H, Hwang T, Tsai Y. Protective effect of tropisetron on rodent hepatic injury after trauma-hemorrhagic shock through P38 MAPK-dependent hemeoxygenase-1 expression. PLoS ONE. 2012;7:e53203 pubmed publisher
    ..These results suggest that the protective effect of tropisetron administration on alleviation of hepatic injury after trauma-hemorrhage is likely mediated through p38 MAPK-dependent HO-1 expression...
  26. Ruzehaji N, Grose R, Krumbiegel D, Zola H, Dasari P, Wallace H, et al. Cytoskeletal protein Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: neutralizing its activity in chronic but not acute wound fluid improves cellular proliferation. Eur J Dermatol. 2012;22:740-50 pubmed publisher
    ..Application of FnAbs to chronic wounds may therefore be a novel approach used to improve the local environment of non-healing wounds and potentially improve healing outcomes...
  27. Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, et al. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost. 2013;11:307-14 pubmed publisher
    ..5 million deaths annually from hemorrhage and coagulopathy. Overt hyperfibrinolysis is rare in trauma, and is associated with massive fatal injuries. Paradoxically, clinical trials suggest a much broader indication for antifibrinolytics...
  28. Cotton B, Harvin J, Kostousouv V, Minei K, Radwan Z, Schöchl H, et al. Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. J Trauma Acute Care Surg. 2012;73:365-70; discussion 370 pubmed publisher
    ..To further strengthen this hypothesis, we created an in vitro hemodilution model to improve our mechanistic understanding of the early HF...
  29. Zhu H, Xia X, Xiang H, Yu C, Du Y. Disability, home physical environment and non-fatal injuries among young children in China. PLoS ONE. 2012;7:e37766 pubmed publisher
  30. Roberts I, Shakur H, Ker K, Coats T. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev. 2012;12:CD004896 pubmed
    ..Uncontrolled bleeding is an important cause of death in trauma victims. Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may also be effective in reducing blood loss following trauma...
  31. Mutschler M, Nienaber U, Brockamp T, Wafaisade A, Wyen H, Peiniger S, et al. A critical reappraisal of the ATLS classification of hypovolaemic shock: does it really reflect clinical reality?. Resuscitation. 2013;84:309-13 pubmed publisher
    ..The aim of this study was to validate the classification of hypovolaemic shock given by the Advanced Trauma Life Support (ATLS)...
  32. Haas B, Stukel T, Gomez D, Zagorski B, de Mestral C, Sharma S, et al. The mortality benefit of direct trauma center transport in a regional trauma system: a population-based analysis. J Trauma Acute Care Surg. 2012;72:1510-5; discussion 1515-7 pubmed publisher
    ..Taking a novel, population-based approach, we estimated the potential detrimental impact of undertriage to a non-TC (NTC) within a regional system...
  33. Cotton B, Minei K, Radwan Z, Matijevic N, Pivalizza E, Podbielski J, et al. Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients. J Trauma Acute Care Surg. 2012;72:1470-5; discussion 1475-7 pubmed publisher
    ..The purpose of this study was to identify whether admission rapid-thrombelastography (r-TEG) could identify patients at risk of developing pulmonary embolism (PE) during their hospital stay...
  34. Liu T, Chen J, Bai X, Zheng G, Gao W. The effect of obesity on outcomes in trauma patients: a meta-analysis. Injury. 2013;44:1145-52 pubmed publisher
    ..This study aims to assess the effect of obesity on injury severity score (ISS), mortality and course of hospital stay among trauma patients...
  35. Bobrovitz N, Santana M, Ball C, Kortbeek J, Stelfox H. The development and testing of a survey to measure patient and family experiences with injury care. J Trauma Acute Care Surg. 2012;73:1332-9 pubmed publisher
    ..To deliver patient-centered trauma care, we must capture patient and family experiences with the services they receive. We developed and pilot tested a survey to measure patient and family experiences with major injury care...
  36. Holcomb J, Minei K, Scerbo M, Radwan Z, Wade C, Kozar R, et al. Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients. Ann Surg. 2012;256:476-86 pubmed publisher
    ..We have previously shown that admission r-TEG results are available faster than CCTs and predict pulmonary embolism. We hypothesized that r-TEGs more reliably predict blood component transfusion than CCTs...
  37. Morrison J, Ross J, Dubose J, Jansen J, Midwinter M, Rasmussen T. Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II Study. JAMA Surg. 2013;148:218-25 pubmed publisher
    ..To quantify the impact of fibrinogen-containing cryoprecipitate in addition to the antifibrinolytic tranexamic acid on survival in combat injured...
  38. Ostrowski S, Johansson P. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg. 2012;73:60-6 pubmed publisher
    ..This study evaluated if degradation of the endothelial glycocalyx and ensuing release of its heparin-like substances induce autoheparinization and thereby contributes to TIC...
  39. Ramasubbu D, Smith V, Hayden F, Cronin P. Systemic antibiotics for treating malignant wounds. Cochrane Database Syst Rev. 2017;8:CD011609 pubmed publisher
    ..The aim of antibiotic therapy is to successfully eliminate these bacteria, reduce associated symptoms, such as odour, and promote wound healing...
  40. Chen C, Zhang G, Huang H, Wang J, Tarefder R. Examining driver injury severity outcomes in rural non-interstate roadway crashes using a hierarchical ordered logit model. Accid Anal Prev. 2016;96:79-87 pubmed publisher
    ..Overall, this research provides reasonable results and insight in developing effective road safety measures for crash injury severity reduction and prevention. ..
  41. Chao J, Bledsoe G, Chao L. Protective Role of Kallistatin in Vascular and Organ Injury. Hypertension. 2016;68:533-41 pubmed publisher
  42. Scrafford C, Tielsch J. Maternal Deaths Account for a Small Proportion of the Total Deaths Among Reproductive Age Women. J Womens Health (Larchmt). 2016;25:242-8 pubmed publisher
    ..Research on the causes of death among women and prevention and treatment policies that provide health, education, and nutrition services to women need to be a priority. ..
  43. Zhao M, Yu M, Fang L, Wang H, Wu W, Huang G, et al. [Road-side observational survey on 4 unlawful acts among electric bicycle riders in Zhejiang]. Zhonghua Liu Xing Bing Xue Za Zhi. 2016;37:629-33 pubmed publisher
    ..To investigate the prevalence of key unlawful acts among electric bicycle riders and provide evidence for the development of specific interventions...
  44. Jee C, Eom N, Jang H, Jung H, Choi E, Won J, et al. Effect of autologous platelet-rich plasma application on cutaneous wound healing in dogs. J Vet Sci. 2016;17:79-87 pubmed publisher
    ..Overall, PRP application showed beneficial effects in wound healing, and intralesional injection was useful for application of PRP and could be a good therapeutic option for wound management in dogs. ..
  45. Derner M, Linhart C, Pederson L, Saju S, Heiden A, Wohlford L, et al. Injuries in Adults 65 Years of Age and Older Prescribed Muscle Relaxants. Consult Pharm. 2016;31:511-7 pubmed publisher
    ..The results of this study identified disparities among adults 65 years of age and older presenting to U.S. rural primary care clinics with injury and prescribed an SMR. Adults 65 years of age and older, Collaborative. ..
  46. Skinner O, Cuddy L, Coisman J, Covey J, Ellison G. Temporary Rectal Stenting for Management of Severe Perineal Wounds in Two Dogs. J Am Anim Hosp Assoc. 2016;52:385-391 pubmed
    ..Long-term outcome was deemed excellent. Temporary rectal stenting may be a useful technique for fecal diversion to facilitate resolution of complex perineal injuries, including rectal perforation...
  47. Leonov S, Pinchuk P, Shakir janova J. [The peculiar features of the sidewise collision involving a pedestrian and an automobile moving in the reverse gear along an arc of a circle]. Sud Med Ekspert. 2017;60:32-33 pubmed publisher
  48. Bouzat P, Schilte C, Vinclair M, Manhes P, Brun J, Bosson J, et al. Capillary lactate concentration on admission of normotensive trauma patients: a prospective study. Scand J Trauma Resusc Emerg Med. 2016;24:82 pubmed publisher
    ..Due to large disagreement between capillary lactate and blood lactate, capillary lactate cannot be considered in the clinical setting. ClinicalTrials.gov, No. NCT01793428 . ..
  49. Ramkumar P, Farber J, Arnouk J, Varner K, McCulloch P. Injuries in a Professional Ballet Dance Company: A 10-year Retrospective Study. J Dance Med Sci. 2016;20:30-7 pubmed publisher
    ..Future studies should aim to identify injury risk factors and modalities for prevention of these injuries. ..
  50. Likhterov I, Urken M. Mount Sinai Medical Center and Their Experience with Unfavorable Microsurgical Head and Neck Reconstruction. Clin Plast Surg. 2016;43:631-8 pubmed publisher
    ..Special attention is given to the topic of laryngopharyngeal reconstruction. ..
  51. Kulahci Y, Sahin C, Karagoz H, Zor F. Pre-expanded Thoracodorsal Artery Perforator Flap. Clin Plast Surg. 2017;44:91-97 pubmed publisher
    ..This article presents details on the surgical technique and provides discussion of the authors' experiences. ..
  52. Vela J, Wertz C, Onstott K, Wertz J. Trauma Imaging: A Literature Review. Radiol Technol. 2017;88:263-276 pubmed
    ..To inform radiologic technologists about which imaging modalities and examinations are best suited for evaluating specific anatomical structures in patients who have sustained a traumatic injury...
  53. Zhu J, Chaudhury M, Durso L, Sagel A, Skoda S, Jelvez Serra N, et al. Semiochemicals released from five bacteria identified from animal wounds infested by primary screwworms and their effects on fly behavioral activity. PLoS ONE. 2017;12:e0179090 pubmed publisher
    ..We identified volatile chemicals released from the inoculated blood and other selected media over time and assessed the effect of those chemicals on behavioral activity of adult screwworm flies...