chikungunya virus

Summary

Summary: A species of ALPHAVIRUS causing an acute dengue-like fever.

Top Publications

  1. Fros J, Domeradzka N, Baggen J, Geertsema C, Flipse J, Vlak J, et al. Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci. J Virol. 2012;86:10873-9 pubmed publisher
    b>Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP)...
  2. Kumar N, Suresh A, Vanamail P, Sabesan S, Krishnamoorthy K, Mathew J, et al. Chikungunya virus outbreak in Kerala, India, 2007: a seroprevalence study. Mem Inst Oswaldo Cruz. 2011;106:912-6 pubmed
    India was affected by a major outbreak of chikungunya fever caused by Chikungunya virus (CHIKV) during 2006-2007. Kerala was the worst affected state during 2007 with a contribution of 55.8% suspected cases in the country...
  3. Abere B, Wikan N, Ubol S, Auewarakul P, Paemanee A, Kittisenachai S, et al. Proteomic analysis of chikungunya virus infected microgial cells. PLoS ONE. 2012;7:e34800 pubmed publisher
    b>Chikungunya virus (CHIKV) is a recently re-emerged public health problem in many countries bordering the Indian Ocean and elsewhere...
  4. Chattopadhyay A, Wang E, Seymour R, Weaver S, Rose J. A chimeric vesiculo/alphavirus is an effective alphavirus vaccine. J Virol. 2013;87:395-402 pubmed publisher
    ..The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever...
  5. Suwannakarn K, Theamboonlers A, Poovorawan Y. Molecular genome tracking of East, Central and South African genotype of Chikungunya virus in South-east Asia between 2006 and 2009. Asian Pac J Trop Med. 2011;4:535-40 pubmed publisher
    To understand the epidemiology of the East, Central and South African (ECSA) genotype of Chikungunya virus (CHIKV) in terms of emerging and re-emerging infections, this study has been aimed at investigating the evolutionary parameters, ..
  6. Burt F, Rolph M, Rulli N, Mahalingam S, Heise M. Chikungunya: a re-emerging virus. Lancet. 2012;379:662-71 pubmed publisher
    ..This Seminar focuses on the re-emergence of this disease, the clinical manifestations, pathogenesis of virus-induced arthralgia, diagnostic techniques, and various treatment modalities...
  7. Kishishita N, Takeda N, Anuegoonpipat A, Anantapreecha S. Development of a pseudotyped-lentiviral-vector-based neutralization assay for chikungunya virus infection. J Clin Microbiol. 2013;51:1389-95 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes chikungunya fever in Africa, South Asia, and Southeast Asia...
  8. Sreekumar E, Issac A, Nair S, Hariharan R, Janki M, Arathy D, et al. Genetic characterization of 2006-2008 isolates of Chikungunya virus from Kerala, South India, by whole genome sequence analysis. Virus Genes. 2010;40:14-27 pubmed publisher
    b>Chikungunya virus (CHIKV), a positive-stranded alphavirus, causes epidemic febrile infections characterized by severe and prolonged arthralgia...
  9. Mahendradas P, Shetty R, Malathi J, Madhavan H. Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. Indian J Ophthalmol. 2010;58:545-7 pubmed publisher
    We are reporting a case of bilateral Fuchs' heterochromic iridocyclitis with chikungunya virus infection in the left eye...

More Information

Publications108 found, 100 shown here

  1. Malvy D, Ezzedine K, Mamani Matsuda M, Autran B, Tolou H, Receveur M, et al. Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies. BMC Infect Dis. 2009;9:200 pubmed publisher
    ..Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of ..
  2. Bernard E, Solignat M, Gay B, Chazal N, Higgs S, Devaux C, et al. Endocytosis of chikungunya virus into mammalian cells: role of clathrin and early endosomal compartments. PLoS ONE. 2010;5:e11479 pubmed publisher
    The replicative cycle of chikungunya virus (CHIKV), an alphavirus that recently re-emerged in India and in Indian Ocean area, remains mostly unknown...
  3. Ruiz Moreno D, Vargas I, Olson K, Harrington L. Modeling dynamic introduction of Chikungunya virus in the United States. PLoS Negl Trop Dis. 2012;6:e1918 pubmed publisher
    ..This is the first model to consider Chikungunya risk in the US and can be applied to other vector borne diseases. ..
  4. Tilston N, Skelly C, Weinstein P. Pan-European Chikungunya surveillance: designing risk stratified surveillance zones. Int J Health Geogr. 2009;8:61 pubmed publisher
    ..Therefore this study represents a first attempt at creating risk stratified surveillance zones, which we believe could be usefully refined with the use of higher resolution climate data and more complete air travel data. ..
  5. Khan M, Santhosh S, Tiwari M, Lakshmana Rao P, Parida M. Assessment of in vitro prophylactic and therapeutic efficacy of chloroquine against Chikungunya virus in vero cells. J Med Virol. 2010;82:817-24 pubmed publisher
    The resurgence of Chikungunya virus (CHIKV) in the form of unprecedented and explosive epidemics in India and the Indian Ocean islands after a gap of 32 years is a major public health concern...
  6. Srikanth P, Sarangan G, Mallilankaraman K, Nayar S, Barani R, Mattew T, et al. Molecular characterization of Chikungunya virus during an outbreak in South India. Indian J Med Microbiol. 2010;28:299-302 pubmed publisher
    ..Re-emergence of Chikungunya is a major public health problem in the southern states of India...
  7. Kuo S, Chen Y, Wang Y, Kuo M, Jinn T, Chen W, et al. Cell-based analysis of Chikungunya virus membrane fusion using baculovirus-expression vectors. J Virol Methods. 2011;175:206-15 pubmed publisher
    b>Chikungunya virus infection has emerged in many countries over the past decade. There are no effective drugs for controlling the disease...
  8. Sam I, Loong S, Michael J, Chua C, Wan Sulaiman W, Vythilingam I, et al. Genotypic and phenotypic characterization of Chikungunya virus of different genotypes from Malaysia. PLoS ONE. 2012;7:e50476 pubmed publisher
    Mosquito-borne Chikungunya virus (CHIKV) has recently re-emerged globally. The epidemic East/Central/South African (ECSA) strains have spread for the first time to Asia, which previously only had endemic Asian strains...
  9. Tong J, Simarmata D, Lin R, Rénia L, Ng L. HLA class I restriction as a possible driving force for Chikungunya evolution. PLoS ONE. 2010;5:e9291 pubmed publisher
    ..Early phylogenetic analyses based on partial sequences of Chikungunya virus (CHIKV) have led to speculation that the virus behind recent epidemics may result in greater pathogenicity...
  10. Talbalaghi A, Moutailler S, Vazeille M, Failloux A. Are Aedes albopictus or other mosquito species from northern Italy competent to sustain new arboviral outbreaks?. Med Vet Entomol. 2010;24:83-7 pubmed publisher
    ..It was incriminated as a principal vector in the first European outbreak of chikungunya virus (CHIKV) in the province of Ravenna (Italy) in 2007...
  11. Ayu S, Lai L, Chan Y, Hatim A, Hairi N, Ayob A, et al. Seroprevalence survey of Chikungunya virus in Bagan Panchor, Malaysia. Am J Trop Med Hyg. 2010;83:1245-8 pubmed publisher
    In 2006, an outbreak of Chikungunya virus (CHIKV) of the Asian genotype affected over 200 people in Bagan Panchor village in Malaysia...
  12. Cui J, Gao M, Ren X. Phylogeny and homologous recombination in Chikungunya viruses. Infect Genet Evol. 2011;11:1957-63 pubmed publisher
    The periodic and recent outbreaks of endemic Chikungunya virus (CHIKV) infection have jeopardized the public health in wider geographical regions...
  13. Prow T, Chen X, Prow N, Fernando G, Tan C, Raphael A, et al. Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in mice. Small. 2010;6:1776-84 pubmed publisher
    ..The efficiency of NP immunization is demonstrated using an inactivated whole chikungunya virus vaccine and a DNA-delivered attenuated West Nile virus vaccine...
  14. Pulmanausahakul R, Roytrakul S, Auewarakul P, Smith D. Chikungunya in Southeast Asia: understanding the emergence and finding solutions. Int J Infect Dis. 2011;15:e671-6 pubmed publisher
    ..of the current epidemic of chikungunya in Southeast Asia is being driven by the emergence of a strain of chikungunya virus that originated in Africa and spread to islands in the Indian Ocean, as well as to India and Sri Lanka, and ..
  15. Delatte H, Bagny L, Brengue C, Bouetard A, Paupy C, Fontenille D. The invaders: phylogeography of dengue and chikungunya viruses Aedes vectors, on the South West islands of the Indian Ocean. Infect Genet Evol. 2011;11:1769-81 pubmed publisher
  16. Raharimalala F, Ravaomanarivo L, Ravelonandro P, Rafarasoa L, Zouache K, Tran Van V, et al. Biogeography of the two major arbovirus mosquito vectors, Aedes aegypti and Aedes albopictus (Diptera, Culicidae), in Madagascar. Parasit Vectors. 2012;5:56 pubmed publisher
    ..Experimental infections with the chikungunya virus strain 06.21 at a titer of 107...
  17. Ramful D, Samperiz S, Fritel X, Michault A, Jaffar Bandjee M, Rollot O, et al. Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection. J Infect Dis. 2014;209:1726-30 pubmed publisher
    ..serological evidence of congenital infection in apparently healthy neonates born to women infected with the Chikungunya virus (CHIKV) during pregnancy, monitoring for CHIKV-specific antibodies was performed within the CHIMERE cohort ..
  18. Kelvin A. Outbreak of Chikungunya in the Republic of Congo and the global picture. J Infect Dev Ctries. 2011;5:441-4 pubmed
    ..Although Chikungunya virus is not often associated with mortality, the effects of virus outbreaks are often devastating, causing ..
  19. Palha N, Guivel Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, et al. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013;9:e1003619 pubmed publisher
    b>Chikungunya Virus (CHIKV), a re-emerging arbovirus that may cause severe disease, constitutes an important public health problem...
  20. Volk S, Chen R, Tsetsarkin K, Adams A, Garcia T, Sall A, et al. Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates. J Virol. 2010;84:6497-504 pubmed publisher
    b>Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has traditionally circulated in Africa and Asia, causing human febrile illness accompanied by severe, chronic joint pain...
  21. Schwartz O, Albert M. Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol. 2010;8:491-500 pubmed publisher
    b>Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for a recent, unexpectedly severe epidemic in countries of the Indian Ocean region...
  22. Duong V, Andries A, Ngan C, Sok T, Richner B, Asgari Jirhandeh N, et al. Reemergence of Chikungunya virus in Cambodia. Emerg Infect Dis. 2012;18:2066-9 pubmed publisher
    b>Chikungunya virus (CHIKV), probably Asian genotype, was first detected in Cambodia in 1961...
  23. Sam I, Kamarulzaman A, Ong G, Veriah R, Ponnampalavanar S, Chan Y, et al. Chikungunya virus-associated death in Malaysia. Trop Biomed. 2010;27:343-7 pubmed
    b>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which causes fever, rash, and arthralgia. In the past, life-threatening complications were very rarely reported...
  24. Tsetsarkin K, McGee C, Higgs S. Chikungunya virus adaptation to Aedes albopictus mosquitoes does not correlate with acquisition of cholesterol dependence or decreased pH threshold for fusion reaction. Virol J. 2011;8:376 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito transmitted alphavirus that recently caused several large scale outbreaks/epidemics of arthritic disease in tropics of Africa, Indian Ocean basin and South-East Asia...
  25. Patil D, Hundekar S, Arankalle V. Expression profile of immune response genes during acute myopathy induced by chikungunya virus in a mouse model. Microbes Infect. 2012;14:457-69 pubmed publisher
    ..This is the first report of comprehensive analysis of immune response genes expression in target tissue of CHIKV mouse model. The data would contribute significantly in understanding pathogenesis of CHIKV disease and viral myopathies. ..
  26. Judith D, Mostowy S, Bouraï M, Gangneux N, Lelek M, Lucas Hourani M, et al. Species-specific impact of the autophagy machinery on Chikungunya virus infection. EMBO Rep. 2013;14:534-44 pubmed publisher
    b>Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect...
  27. Ansumana R, Jacobsen K, Leski T, Covington A, Bangura U, Hodges M, et al. Reemergence of chikungunya virus in Bo, Sierra Leone. Emerg Infect Dis. 2013;19:1108-10 pubmed publisher
    We diagnosed 400 possible IgM-positive cases of chikungunya virus in Bo, Sierra Leone, during July 2012-January 2013 by using lateral flow immunoassays. Cases detected likely represent only a small fraction of total cases...
  28. Lam S, Chen K, Ng M, Chu J. Expression of plasmid-based shRNA against the E1 and nsP1 genes effectively silenced Chikungunya virus replication. PLoS ONE. 2012;7:e46396 pubmed publisher
    b>Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes chikungunya fever and persistent arthralgia in humans. Currently, there is no effective vaccine or antiviral against CHIKV infection...
  29. Chow A, Her Z, Ong E, Chen J, Dimatatac F, Kwek D, et al. Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor. J Infect Dis. 2011;203:149-57 pubmed publisher
    b>Chikungunya virus (CHIKV) infection induces arthralgia. The involvement of inflammatory cytokines and chemokines has been suggested, but very little is known about their secretion profile in CHIKV-infected patients.
  30. Powers A. Chikungunya. Clin Lab Med. 2010;30:209-19 pubmed publisher
    b>Chikungunya virus is a zoonotic, vector-borne pathogen that has been responsible for numerous outbreaks of febrile arthralgia since its discovery in the early 1950s...
  31. Manimunda S, Sugunan A, Rai S, Vijayachari P, Shriram A, Sharma S, et al. Outbreak of chikungunya fever, Dakshina Kannada District, South India, 2008. Am J Trop Med Hyg. 2010;83:751-4 pubmed publisher
    ..Dakshina Kannada District of Karnataka State to estimate the magnitude of the epidemic and the proportion of chikungunya virus (CHIKV) infections that remained clinically inapparent. The seropositivity for CHIKV infection was 62...
  32. Caron M, Paupy C, Grard G, Becquart P, Mombo I, Nso B, et al. Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa. Clin Infect Dis. 2012;55:e45-53 pubmed publisher
    b>Chikungunya virus (CHIKV) and Dengue virus serotype 2 (DENV-2) were recently introduced in central Africa, along with Aedes albopictus...
  33. Her Z, Malleret B, Chan M, Ong E, Wong S, Kwek D, et al. Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response. J Immunol. 2010;184:5903-13 pubmed publisher
    b>Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthralgia in humans. To date, interactions between the immune system and the different stages of the virus life cycle remain poorly defined...
  34. Vega Rua A, Zouache K, Caro V, Diancourt L, Delaunay P, Grandadam M, et al. High efficiency of temperate Aedes albopictus to transmit chikungunya and dengue viruses in the Southeast of France. PLoS ONE. 2013;8:e59716 pubmed publisher
    ..In 2010, autochthonous cases of CHIK and dengue (DEN) were reported in southeastern France. We evaluated the potential of a French population of Ae. albopictus in the transmission of both viruses...
  35. Labadie K, Larcher T, Joubert C, Mannioui A, Delache B, Brochard P, et al. Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. J Clin Invest. 2010;120:894-906 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints...
  36. Voss J, Vaney M, Duquerroy S, Vonrhein C, Girard Blanc C, Crublet E, et al. Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography. Nature. 2010;468:709-12 pubmed publisher
    b>Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused widespread outbreaks of debilitating human disease in the past five years...
  37. Grandadam M, Caro V, Plumet S, Thiberge J, Souares Y, Failloux A, et al. Chikungunya virus, southeastern France. Emerg Infect Dis. 2011;17:910-3 pubmed publisher
    In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present...
  38. Thangamani S, Higgs S, Ziegler S, Vanlandingham D, Tesh R, Wikel S. Host immune response to mosquito-transmitted chikungunya virus differs from that elicited by needle inoculated virus. PLoS ONE. 2010;5:e12137 pubmed publisher
    ..In this report, we compared host immune responses to chikungunya virus (CHIKV) transmission by (1) mosquito bite, or (2) by needle inoculation.
  39. Rulli N, Rolph M, Srikiatkhachorn A, Anantapreecha S, Guglielmotti A, Mahalingam S. Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis. J Infect Dis. 2011;204:1026-30 pubmed publisher
    b>Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans...
  40. Wu D, Zhang Y, Zhouhui Q, Kou J, Liang W, Zhang H, et al. Chikungunya virus with E1-A226V mutation causing two outbreaks in 2010, Guangdong, China. Virol J. 2013;10:174 pubmed publisher
    ..To confirm the hypothesis and determine the origin of CHIKV causing the outbreaks, we described Yangjiang outbreak in this study, and the molecular characterization of CHIKV from Yangjiang and Dongguang outbreaks were analyzed...
  41. Das T, Jaffar Bandjee M, Hoarau J, Krejbich Trotot P, Denizot M, Lee Pat Yuen G, et al. Chikungunya fever: CNS infection and pathologies of a re-emerging arbovirus. Prog Neurobiol. 2010;91:121-9 pubmed publisher
    b>Chikungunya virus (CHIKV) is transmitted by Aedes mosquitoes and causes an acute symptomatic illness with fever, skin rash, and incapacitating arthralgia, which can evolve into chronic rheumatoid arthritis in elderly patients...
  42. Moreira L, Iturbe Ormaetxe I, Jeffery J, Lu G, Pyke A, Hedges L, et al. A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium. Cell. 2009;139:1268-78 pubmed publisher
    ..We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases...
  43. Schilte C, Couderc T, Chretien F, Sourisseau M, Gangneux N, Guivel Benhassine F, et al. Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. J Exp Med. 2010;207:429-42 pubmed publisher
    b>Chikungunya virus (CHIKV) is the causative agent of an outbreak that began in La Réunion in 2005 and remains a major public health concern in India, Southeast Asia, and southern Europe...
  44. Martin E, Moutailler S, Madec Y, Failloux A. Differential responses of the mosquito Aedes albopictus from the Indian Ocean region to two chikungunya isolates. BMC Ecol. 2010;10:8 pubmed publisher
    Aedes aegypti and Aedes albopictus are both vectors of chikungunya virus (CHIKV). The two Aedes species co-exist in the Indian Ocean region and were involved in the 2005-2006 CHIKV outbreaks...
  45. Mavale M, Parashar D, Sudeep A, Gokhale M, Ghodke Y, Geevarghese G, et al. Venereal transmission of chikungunya virus by Aedes aegypti mosquitoes (Diptera: Culicidae). Am J Trop Med Hyg. 2010;83:1242-4 pubmed publisher
    ..conducted to demonstrate the role of male Aedes aegypti mosquitoes in the maintenance and transmission of chikungunya virus (CHIKV) to female mosquitoes...
  46. Chusri S, Siripaitoon P, Hirunpat S, Silpapojakul K. Case reports of neuro-Chikungunya in southern Thailand. Am J Trop Med Hyg. 2011;85:386-9 pubmed publisher
    ..been a recent increase in reports of neurologic complications as major causes of morbidity and mortality in chikungunya virus infection...
  47. Fritel X, Rollot O, Gerardin P, Gauzere B, Bideault J, Lagarde L, et al. Chikungunya virus infection during pregnancy, Reunion, France, 2006. Emerg Infect Dis. 2010;16:418-25 pubmed publisher
    Mother-to-child transmission of chikungunya virus was reported during the 2005-2006 outbreak on Reunion Island, France...
  48. Hoarau J, Jaffar Bandjee M, Krejbich Trotot P, Das T, Li Pat Yuen G, Dassa B, et al. Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response. J Immunol. 2010;184:5914-27 pubmed publisher
    Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized...
  49. Paupy C, Kassa Kassa F, Caron M, Nkoghe D, Leroy E. A chikungunya outbreak associated with the vector Aedes albopictus in remote villages of Gabon. Vector Borne Zoonotic Dis. 2012;12:167-9 pubmed publisher
    b>Chikungunya virus (CHIKV) recently caused major urban outbreaks in central African countries such as the Democratic Republic of Congo (DRC), Cameroon, and Gabon...
  50. Tsetsarkin K, Weaver S. Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence. PLoS Pathog. 2011;7:e1002412 pubmed publisher
    The adaptation of Chikungunya virus (CHIKV) to a new vector, the Aedes albopictus mosquito, is a major factor contributing to its ongoing re-emergence in a series of large-scale epidemics of arthritic disease in many parts of the world ..
  51. Kam Y, Simarmata D, Chow A, Her Z, Teng T, Ong E, et al. Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection. J Infect Dis. 2012;205:1147-54 pubmed publisher
    b>Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact...
  52. Rashad A, Mahalingam S, Keller P. Chikungunya virus: emerging targets and new opportunities for medicinal chemistry. J Med Chem. 2014;57:1147-66 pubmed publisher
    b>Chikungunya virus is an emerging arbovirus that is widespread in tropical regions and is spreading quickly to temperate climates with recent epidemics in Africa and Asia and documented outbreaks in Europe and the Americas...
  53. Ho P, Ng M, Chu J. Establishment of one-step SYBR green-based real time-PCR assay for rapid detection and quantification of chikungunya virus infection. Virol J. 2010;7:13 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus and one of the prevalent re-emerging arbovirus in tropical and subtropical regions of Asia, Africa, and Central and South America...
  54. Sissoko D, Ezzedine K, Moendandze A, Giry C, Renault P, Malvy D. Field evaluation of clinical features during chikungunya outbreak in Mayotte, 2005-2006. Trop Med Int Health. 2010;15:600-7 pubmed publisher
    ..To record and assess the clinical features of chikungunya fever (CHIKF), with a view to enable diagnosis based on clinical criteria rather than costly laboratory procedures in field conditions...
  55. Yap G, Pok K, Lai Y, Hapuarachchi H, Chow A, Leo Y, et al. Evaluation of Chikungunya diagnostic assays: differences in sensitivity of serology assays in two independent outbreaks. PLoS Negl Trop Dis. 2010;4:e753 pubmed publisher
    ..of commercially-available CTK lateral flow rapid test and EUROIMMUN IFA assays for the detection of anti-Chikungunya virus (CHIKV) IgM...
  56. Boura M, Lucas Hourani M, Gad H, Drosten C, Jacob Y, Tafforeau L, et al. Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component. J Virol. 2012;86:3121-34 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has been responsible for an epidemic outbreak of unprecedented magnitude in recent years...
  57. Akhrymuk I, Kulemzin S, Frolova E. Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II. J Virol. 2012;86:7180-91 pubmed publisher
    ..The latest epidemic of Chikungunya virus, from 2005 to 2007, affected over 40 countries in Africa, Asia, and Europe...
  58. Islam M, Hossain M, Khaleque M, Karim M, Khan M, Mia A, et al. Chikungunya virus infection, a threat to public health. Mymensingh Med J. 2012;21:372-6 pubmed
    Many countries in the world have reported human infections by chikungunya virus (CHIKV) a mosquito-borne togavirus belonging to the genus alpha virus...
  59. Shrinet J, Jain S, Sharma A, Singh S, Mathur K, Rana V, et al. Genetic characterization of Chikungunya virus from New Delhi reveal emergence of a new molecular signature in Indian isolates. Virol J. 2012;9:100 pubmed publisher
    ..This was the first incidence of a dominant CHIK outbreak in Delhi and prompted us to characterize the Delhi virus strains. We have also investigated the evolution of CHIK spread in India...
  60. Fric J, Bertin Maghit S, WANG C, Nardin A, Warter L. Use of human monoclonal antibodies to treat Chikungunya virus infection. J Infect Dis. 2013;207:319-22 pubmed publisher
    b>Chikungunya virus (CHIKV) is an alphavirus prevalent in tropical regions. It causes an acute febrile disease that, in elderly individuals and newborns, is often associated with severe complications...
  61. Weaver S, Osorio J, Livengood J, Chen R, Stinchcomb D. Chikungunya virus and prospects for a vaccine. Expert Rev Vaccines. 2012;11:1087-101 pubmed publisher
    In 2004, chikungunya virus (CHIKV) re-emerged from East Africa to cause devastating epidemics of debilitating and often chronic arthralgia that have affected millions of people in the Indian Ocean Basin and Asia...
  62. Randrianasolo L, Raoelina Y, Ratsitorahina M, Ravolomanana L, Andriamandimby S, Heraud J, et al. Sentinel surveillance system for early outbreak detection in Madagascar. BMC Public Health. 2010;10:31 pubmed publisher
    ..We describe the challenges and steps involved in developing a sentinel surveillance system and the well-timed information it provides for improving public health decision-making...
  63. Chem Y, Zainah S, Berendam S, Rogayah T, Khairul A, Chua K. Molecular epidemiology of chikungunya virus in Malaysia since its first emergence in 1998. Med J Malaysia. 2010;65:31-5 pubmed
    ..The strain that was introduced into Johor state was responsible for its subsequent spread to other parts of Malaysia, inclusive of Sarawak...
  64. Warter L, Lee C, Thiagarajan R, Grandadam M, Lebecque S, Lin R, et al. Chikungunya virus envelope-specific human monoclonal antibodies with broad neutralization potency. J Immunol. 2011;186:3258-64 pubmed publisher
    b>Chikungunya virus (CHIKV) is an alphavirus responsible for numerous epidemics in Africa and Asia...
  65. Ziegler S, NUCKOLS J, McGee C, Huang Y, Vanlandingham D, Tesh R, et al. In vivo imaging of chikungunya virus in mice and Aedes mosquitoes using a Renilla luciferase clone. Vector Borne Zoonotic Dis. 2011;11:1471-7 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that in humans causes an acute febrile illness characterized by fever, arthralgia, and rash...
  66. Bellini R, Medici A, Calzolari M, Bonilauri P, Cavrini F, Sambri V, et al. Impact of Chikungunya virus on Aedes albopictus females and possibility of vertical transmission using the actors of the 2007 outbreak in Italy. PLoS ONE. 2012;7:e28360 pubmed publisher
    ..Field observations conducted during the Spring 2008 showed no evidence of the presence of infected overwintering progeny produced by Ae. albopictus females infected during the 2007 outbreak...
  67. Shoji Kawata S, Sumpter R, Leveno M, Campbell G, Zou Z, Kinch L, et al. Identification of a candidate therapeutic autophagy-inducing peptide. Nature. 2013;494:201-6 pubmed publisher
    ..Thus, through the characterization of a domain of beclin 1 that interacts with HIV-1 Nef, we have developed an autophagy-inducing peptide that has potential efficacy in the treatment of human diseases...
  68. Delogu I, Pastorino B, Baronti C, Nougairede A, Bonnet E, de Lamballerie X. In vitro antiviral activity of arbidol against Chikungunya virus and characteristics of a selected resistant mutant. Antiviral Res. 2011;90:99-107 pubmed publisher
    ..Here, the in vitro antiviral effect of ARB on Chikungunya virus (CHIKV) replication was investigated and this compound was found to present potent inhibitory activity ..
  69. Dwibedi B, SABAT J, Mahapatra N, Kar S, Kerketta A, Hazra R, et al. Rapid spread of chikungunya virus infection in Orissa: India. Indian J Med Res. 2011;133:316-21 pubmed
    ..Epidemiological and laboratory investigation were carried out to confirm the cause of emerging illness, which was provisionally suspected as Chikungunya (CHIK) fever...
  70. Gobbi F, Barzon L, Capelli G, Angheben A, Pacenti M, Napoletano G, et al. Surveillance for West Nile, dengue, and chikungunya virus infections, Veneto Region, Italy, 2010. Emerg Infect Dis. 2012;18:671-3 pubmed publisher
    ..Surveillance highlighted the need to modify case definitions, train physicians, and when a case is identified, implement vector control measures...
  71. Wintachai P, Wikan N, Kuadkitkan A, Jaimipuk T, Ubol S, Pulmanausahakul R, et al. Identification of prohibitin as a Chikungunya virus receptor protein. J Med Virol. 2012;84:1757-70 pubmed publisher
    b>Chikungunya virus (CHIKV) has recently re-emerged causing millions of infections in countries around the Indian Ocean...
  72. Rathore A, Ng M, Vasudevan S. Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2? phosphorylation. Virol J. 2013;10:36 pubmed publisher
    ..This study provides insight into a mechanism by which CHIKV replication responds to overcome the host UPR machinery...
  73. Kosasih H, de Mast Q, Widjaja S, Sudjana P, Antonjaya U, Ma roef C, et al. Evidence for endemic chikungunya virus infections in Bandung, Indonesia. PLoS Negl Trop Dis. 2013;7:e2483 pubmed publisher
    b>Chikungunya virus (CHIKV) is known to cause sporadic or explosive outbreaks. However, little is known about the endemic transmission of CHIKV...
  74. Santhosh S, Dash P, Parida M, Khan M, Rao P. Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak. Virol J. 2009;6:172 pubmed publisher
    ..isolation, RT-PCR and genome sequencing revealed the presence and continued circulation of A226V mutant Chikungunya virus. The appearance of this mutant virus was found to be associated with higher prevalence of vector Aedes ..
  75. van den Hurk A, Hall Mendelin S, Pyke A, Smith G, Mackenzie J. Vector competence of Australian mosquitoes for chikungunya virus. Vector Borne Zoonotic Dis. 2010;10:489-95 pubmed publisher
    b>Chikungunya virus (CHIKV) is a globally emerging arbovirus responsible for unprecedented outbreaks in the western Indian Ocean, the Indian subcontinent and Italy...
  76. Akahata W, Nabel G. A specific domain of the Chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine design. J Virol. 2012;86:8879-83 pubmed publisher
    Virus-like particles (VLPs) can be generated from Chikungunya virus (CHIKV), but different strains yield variable quantities of particles...
  77. Bassetto M, De Burghgraeve T, Delang L, Massarotti A, Coluccia A, Zonta N, et al. Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus. Antiviral Res. 2013;98:12-8 pubmed publisher
    b>Chikungunya virus (CHIKV) is an Arbovirus that is transmitted to humans primarily by the mosquito species Aedes aegypti. Infection with this pathogen is often associated with fever, rash and arthralgia...
  78. Patramool S, Bernard E, Hamel R, Natthanej L, Chazal N, Surasombatpattana P, et al. Isolation of infectious chikungunya virus and dengue virus using anionic polymer-coated magnetic beads. J Virol Methods. 2013;193:55-61 pubmed publisher
    Mosquitoes-borne viruses are a major threat for human populations. Among them, chikungunya virus (CHIKV) and dengue virus (DENV) cause thousands of cases worldwide...
  79. Messaoudi I, Vomaske J, Totonchy T, Kreklywich C, Haberthur K, Springgay L, et al. Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity. PLoS Negl Trop Dis. 2013;7:e2343 pubmed publisher
    b>Chikungunya virus (CHIKV) is a re-emerging mosquito-borne Alphavirus that causes a clinical disease involving fever, myalgia, nausea and rash...
  80. Hawman D, Stoermer K, Montgomery S, Pal P, Oko L, Diamond M, et al. Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response. J Virol. 2013;87:13878-88 pubmed publisher
    b>Chikungunya virus (CHIKV) is a reemerging mosquito-borne pathogen that causes incapacitating disease in humans characterized by intense joint pain that can persist for weeks, months, or even years...
  81. Bouquillard E, Combe B. A report of 21 cases of rheumatoid arthritis following Chikungunya fever. A mean follow-up of two years. Joint Bone Spine. 2009;76:654-7 pubmed publisher
    ..We report 21 cases of rheumatoid arthritis (RA) after Chikungunya infection that were diagnosed at a rheumatological centre in Reunion Island...
  82. Petersen L, Stramer S, Powers A. Chikungunya virus: possible impact on transfusion medicine. Transfus Med Rev. 2010;24:15-21 pubmed publisher
    In recent years, large chikungunya virus (CHIKV) outbreaks originating in Kenya have spread to islands of the Indian Ocean and parts of India, Southeast Asia, and Europe...
  83. Soumahoro M, Fontenille D, Turbelin C, Pelat C, Boyd A, Flahault A, et al. Imported chikungunya virus infection. Emerg Infect Dis. 2010;16:162-3 pubmed publisher
  84. Kumar N, Nadimpalli M, Vardhan V, Gopal S. Association of ABO blood groups with Chikungunya virus. Virol J. 2010;7:140 pubmed publisher
    b>Chikungunya virus (CHIKV) an emerging arboviral infection of public health concern belongs to the genus Alphavirus, family Togaviridae. Blood group antigens are generally known to act as receptors for various etiological agents...
  85. Kosasih H, Widjaja S, Surya E, Hadiwijaya S, Butarbutar D, Jaya U, et al. Evaluation of two IgM rapid immunochromatographic tests during circulation of Asian lineage Chikungunya virus. Southeast Asian J Trop Med Public Health. 2012;43:55-61 pubmed
    ..Increasing the reading time from the manufacturer's suggested time of 10 to 20 minutes significantly increased the sensitivity of the SD Bioline test to 68.2%, but did not significantly change its specificity...
  86. Bettadapura J, Herrero L, Taylor A, Mahalingam S. Approaches to the treatment of disease induced by chikungunya virus. Indian J Med Res. 2013;138:762-5 pubmed
    b>Chikungunya virus, a re-emerging mosquito-borne alphavirus, causes fever, rash and persistent arthralgia/arthritis in humans. Severe outbreaks have occurred resulting in infections of millions of people in Southeast Asia and Africa...
  87. Zheng K, Li J, Zhang Q, Liang M, Li C, Lin M, et al. Genetic analysis of chikungunya viruses imported to mainland China in 2008. Virol J. 2010;7:8 pubmed publisher
    b>Chikungunya virus (CHIKV) has caused large outbreaks worldwide in recent years, especially on the islands of the Indian Ocean and India...
  88. Gardner J, Anraku I, Le T, Larcher T, Major L, Roques P, et al. Chikungunya virus arthritis in adult wild-type mice. J Virol. 2010;84:8021-32 pubmed publisher
    b>Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus...
  89. Win M, Chow A, Dimatatac F, Go C, Leo Y. Chikungunya fever in Singapore: acute clinical and laboratory features, and factors associated with persistent arthralgia. J Clin Virol. 2010;49:111-4 pubmed publisher
    ..During the initial outbreak period, a strict containment strategy was adopted and all chikungunya PCR-confirmed cases were isolated and hospitalised at the designated national outbreak management centre...
  90. Powers A. Genomic evolution and phenotypic distinctions of Chikungunya viruses causing the Indian Ocean outbreak. Exp Biol Med (Maywood). 2011;236:909-14 pubmed publisher
    ..One dramatic example of this has been the emergence of Chikungunya virus (CHIKV), which causes a severe, prolonged, and debilitating arthralgic disease...
  91. Kelvin A, Banner D, Silvi G, Moro M, Spataro N, Gaibani P, et al. Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severity. PLoS Negl Trop Dis. 2011;5:e1279 pubmed publisher
    The Chikungunya virus infection zones have now quickly spread from Africa to parts of Asia, North America and Europe...
  92. Kam Y, Lum F, Teo T, Lee W, Simarmata D, Harjanto S, et al. Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein. EMBO Mol Med. 2012;4:330-43 pubmed publisher
    b>Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. The immune mechanisms, which control viral multiplication and dissemination, are not yet known...