reoviridae

Summary

Summary: A family of unenveloped RNA viruses with cubic symmetry. The twelve genera include ORTHOREOVIRUS; ORBIVIRUS; COLTIVIRUS; ROTAVIRUS; Aquareovirus, Cypovirus, Phytoreovirus, Fijivirus, Seadornavirus, Idnoreovirus, Mycoreovirus, and Oryzavirus.

Top Publications

  1. Cheng L, Fang Q, Shah S, Atanasov I, Zhou Z. Subnanometer-resolution structures of the grass carp reovirus core and virion. J Mol Biol. 2008;382:213-22 pubmed publisher
    Grass carp reovirus (GCRV) is a member of the Aquareovirus genus of the family Reoviridae, a large family of double-stranded RNA (dsRNA) viruses infecting plants, insects, fishes and mammals...
  2. Graham R, Morin B, Lapointe R, Nealis V, Lucarotti C. Molecular characterisation of a cypovirus isolated from the western spruce budworm Choristoneura occidentalis. Arch Virol. 2008;153:1759-63 pubmed publisher
    ..putative RNA-dependent RNA polymerase protein, confirmed CoCPV belonged to the genus Cypovirus within the family Reoviridae. Further phylogenetic analysis using S10 (the polyhedrin gene) aligned this virus with species type-16, closely ..
  3. Ijiri H, Coulibaly F, Nishimura G, Nakai D, Chiu E, Takenaka C, et al. Structure-based targeting of bioactive proteins into cypovirus polyhedra and application to immobilized cytokines for mammalian cell culture. Biomaterials. 2009;30:4297-308 pubmed publisher
    ..The results demonstrate the utility and flexibility of modified polyhedra for encapsulating and stabilizing bioactive proteins. ..
  4. Ilett E, Prestwich R, Kottke T, Errington F, Thompson J, Harrington K, et al. Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity. Gene Ther. 2009;16:689-99 pubmed publisher
    ..These findings are therefore of direct translational relevance for the future design of clinical trials. ..
  5. Maroniche G, Mongelli V, Peralta A, Dist fano A, Llauger G, Taboga O, et al. Functional and biochemical properties of Mal de Río Cuarto virus (Fijivirus, Reoviridae) P9-1 viroplasm protein show further similarities to animal reovirus counterparts. Virus Res. 2010;152:96-103 pubmed publisher
    Mal de Río Cuarto virus (MRCV) is a plant virus of the genus Fijivirus within the family Reoviridae that infects several monocotyledonous species and is transmitted by planthoppers in a persistent and propagative manner...
  6. Berens H, Tyler K. The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. J Virol. 2011;85:3858-71 pubmed publisher
  7. Cai L, Sun X, Shao L, Fang Q. Functional investigation of grass carp reovirus nonstructural protein NS80. Virol J. 2011;8:168 pubmed publisher
  8. Maroniche G, Mongelli V, Llauger G, Alfonso V, Taboga O, del Vas M. In vivo subcellular localization of Mal de Río Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions. Virology. 2012;430:81-9 pubmed publisher
    The in vivo subcellular localization of Mal de Río Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy...
  9. Wu J, Ni Y, Liu H, Rao L, Zhou Y, Zhou X. Development and use of three monoclonal antibodies for the detection of rice black-streaked dwarf virus in field plants and planthopper vectors. Virol J. 2013;10:114 pubmed publisher
    ..The field survey demonstrated that RBSDV is widespread in rice, maize and wheat crops in Jiangsu, Zhejiang, Shandong provinces of China. ..

More Information

Publications102 found, 100 shown here

  1. Yu X, Jin L, Zhou Z. 3.88 A structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy. Nature. 2008;453:415-9 pubmed publisher
    Cytoplasmic polyhedrosis virus (CPV) is unique within the Reoviridae family in having a turreted single-layer capsid contained within polyhedrin inclusion bodies, yet being fully capable of cell entry and endogenous RNA transcription...
  2. Zhou P, Ren B, Zhang X, Wang Y, Wei C, Li Y. Stable expression of rice dwarf virus Pns10 suppresses the post-transcriptional gene silencing in transgenic Nicotiana benthamiana plants. Acta Virol. 2010;54:99-104 pubmed
    ..In particular, the transgenic plants stably expressing a viral suppressor of RNAi (VSR) provide a model system for investigating the mechanism of RNA silencing.<br /> RNA silencing; VSR; Rice dwarf virus; Pns10; transgenic plant. ..
  3. Fan C, Shao L, Fang Q. Characterization of the nonstructural protein NS80 of grass carp reovirus. Arch Virol. 2010;155:1755-63 pubmed publisher
    Nonstructural proteins of members of the family Reoviridae are believed to play significant roles in the virus replication cycle...
  4. Wang Z, Yu D, Li X, Zeng M, Chen Z, Bi L, et al. The development and application of a Dot-ELISA assay for diagnosis of southern rice black-streaked dwarf disease in the field. Viruses. 2012;4:167-83 pubmed publisher
    ..Furthermore, the test results in the county laboratories showed that Libo, Dehong (suspected samples were sent to Shidian) and Jianghua were experiencing a current SRBSDV outbreak. ..
  5. Zhang C, Liu Y, Liu L, Lou Z, Zhang H, Miao H, et al. Rice black streaked dwarf virus P9-1, an alpha-helical protein, self-interacts and forms viroplasms in vivo. J Gen Virol. 2008;89:1770-6 pubmed publisher
    Replication and assembly of viruses from the family Reoviridae are thought to take place in discrete cytoplasmic inclusion bodies, commonly called viral factories or viroplasms...
  6. Dist fano A, Hopp H, del Vas M. Sequence analysis of genome segments S5 and S10 of Mal de Rio Cuarto virus (Fijivirus, Reoviridae). Arch Virol. 2005;150:1241-8 pubmed publisher
    Mal de Rio Cuarto virus (MRCV) was recently described as a new species of the genus Fijivirus, family Reoviridae. The nucleotide sequence of two MRCV genome segments was determined. MRCV S5 and S10 were predicted to encode proteins of 106...
  7. Danthi P, Guglielmi K, Kirchner E, MAINOU B, Stehle T, Dermody T. From touchdown to transcription: the reovirus cell entry pathway. Curr Top Microbiol Immunol. 2010;343:91-119 pubmed publisher
    Mammalian orthoreoviruses (reoviruses) are prototype members of the Reoviridae family of nonenveloped viruses. Reoviruses contain ten double-stranded RNA gene segments enclosed in two concentric protein shells, outer capsid and core...
  8. Su J, Zhang R, Dong J, Yang C. Evaluation of internal control genes for qRT-PCR normalization in tissues and cell culture for antiviral studies of grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2011;30:830-5 pubmed publisher
    ..These data laid the foundation for more precise results in qRT-PCR studies of gene expression in grass carp. ..
  9. Shao L, Sun X, Fang Q. Antibodies against outer-capsid proteins of grass carp reovirus expressed in E. coli are capable of neutralizing viral infectivity. Virol J. 2011;8:347 pubmed publisher
    ..of hemorrhagic disease in aquatic animals, is a highly pathogenic agent in the Aquareovirus genus of family Reoviridae. The outer capsid shell of GCRV, composed of the VP5-VP7 protein complex, is believed to be involved in cell ..
  10. Akita F, Higashiura A, Shimizu T, Pu Y, Suzuki M, Uehara Ichiki T, et al. Crystallographic analysis reveals octamerization of viroplasm matrix protein P9-1 of Rice black streaked dwarf virus. J Virol. 2012;86:746-56 pubmed publisher
    ..that appear to play an important role in viral morphogenesis and are commonly found in viruses in the family Reoviridae. Crystallographic analysis of P9-1 revealed structural features that allow the protein to form dimers via ..
  11. Smakman N, van den Wollenberg D, Borel Rinkes I, Hoeben R, Kranenburg O. Sensitization to apoptosis underlies KrasD12-dependent oncolysis of murine C26 colorectal carcinoma cells by reovirus T3D. J Virol. 2005;79:14981-5 pubmed
    ..We conclude that sensitization of C26 tumor cells to reovirus-induced apoptosis underlies the Ras dependency of reovirus T3D oncolysis. ..
  12. Attoui H, Mohd Jaafar F, de Micco P, de Lamballerie X. Coltiviruses and seadornaviruses in North America, Europe, and Asia. Emerg Infect Dis. 2005;11:1673-9 pubmed
    ..Evidence suggests that BAV is responsible for encephalitis in humans. Infection with BAV may be underreported because it circulates in regions with a high incidence of Japanese encephalitis and could be misdiagnosed as this disease...
  13. Cheng L, Zhu J, Hui W, Zhang X, Honig B, Fang Q, et al. Backbone model of an aquareovirus virion by cryo-electron microscopy and bioinformatics. J Mol Biol. 2010;397:852-63 pubmed publisher
    Grass carp reovirus (GCRV) is a member of the aquareovirus genus in the Reoviridae family and has a capsid with two shells-a transcription-competent core surrounded by a coat...
  14. Chavali V, Ghosh A. Molecular cloning, sequence analysis and expression of genome segment 7 (S7) of Antheraea mylitta cypovirus (AmCPV) that encodes a viral structural protein. Virus Genes. 2007;35:433-41 pubmed
  15. Zhou T, Du L, Fan Y, Zhou Y. Reverse transcription loop-mediated isothermal amplification of RNA for sensitive and rapid detection of southern rice black-streaked dwarf virus. J Virol Methods. 2012;180:91-5 pubmed publisher
    ..This simple and sensitive RT-LAMP assay shows potential for detection of SRBSDV in field samples of hosts or vectors at a relatively low cost. ..
  16. Yan L, Guo H, Sun X, Shao L, Fang Q. Characterization of grass carp reovirus minor core protein VP4. Virol J. 2012;9:89 pubmed publisher
    Grass Carp Reovirus (GCRV), a tentative member in the genus Aquareovirus of family Reoviridae, contains eleven segmented (double-stranded RNA) dsRNA genome which encodes 12 proteins...
  17. Lai C, Mainou B, Kim K, Dermody T. Directional release of reovirus from the apical surface of polarized endothelial cells. MBio. 2013;4:e00049-13 pubmed publisher
    ..Understanding how reovirus is routed through endothelial cells may aid in the design of antiviral drugs that target this important step in systemic viral infections. ..
  18. Wei T, Uehara Ichiki T, Miyazaki N, Hibino H, Iwasaki K, Omura T. Association of Rice gall dwarf virus with microtubules is necessary for viral release from cultured insect vector cells. J Virol. 2009;83:10830-5 pubmed publisher
    Vector insect cells infected with Rice gall dwarf virus, a member of the family Reoviridae, contained the virus-associated microtubules adjacent to the viroplasms, as revealed by transmission electron, electron tomographic, and confocal ..
  19. Liu Y, Jia D, Chen H, Chen Q, Xie L, Wu Z, et al. The P7-1 protein of southern rice black-streaked dwarf virus, a fijivirus, induces the formation of tubular structures in insect cells. Arch Virol. 2011;156:1729-36 pubmed publisher
    ..Taken together, our results indicate that SRBSDV P7-1 has the intrinsic ability of self-interaction to form tubules growing from the cell surface in the absence of other viral proteins...
  20. Mao Q, Zheng S, Han Q, Chen H, Ma Y, Jia D, et al. New model for the genesis and maturation of viroplasms induced by fijiviruses in insect vector cells. J Virol. 2013;87:6819-28 pubmed publisher
    ..of the viroplasm induced by Southern rice black-streaked dwarf virus (SRBSDV), a fijivirus in the family Reoviridae, during infection of its insect vector...
  21. Smith J, Schmechel S, Raghavan A, Abelson M, Reilly C, Katze M, et al. Reovirus induces and benefits from an integrated cellular stress response. J Virol. 2006;80:2019-33 pubmed
  22. Chavali V, Madhurantakam C, Ghorai S, Roy S, Das A, Ghosh A. Genome segment 6 of Antheraea mylitta cypovirus encodes a structural protein with ATPase activity. Virology. 2008;377:7-18 pubmed publisher
    ..These results suggest that P68 may bind viral RNA through CBS domains and help in replication and transcription through ATP binding and hydrolysis. ..
  23. Danthi P, Pruijssers A, Berger A, Holm G, Zinkel S, Dermody T. Bid regulates the pathogenesis of neurotropic reovirus. PLoS Pathog. 2010;6:e1000980 pubmed publisher
    ..These findings define a role for NF-kappaB-dependent cleavage of Bid in the cell death program initiated by viral infection and link Bid to viral virulence. ..
  24. Zhang L, Chandran K, Nibert M, Harrison S. Reovirus mu1 structural rearrangements that mediate membrane penetration. J Virol. 2006;80:12367-76 pubmed
  25. Wu Z, Wu J, Adkins S, Xie L, Li W. Rice ragged stunt virus segment S6-encoded nonstructural protein Pns6 complements cell-to-cell movement of Tobacco mosaic virus-based chimeric virus. Virus Res. 2010;152:176-9 pubmed publisher
    ..Taken together with previous finding that the Pns6 has nucleic acid-binding activity (Shao et al., 2004), the possible role of Pns6 in cell-to-cell movement of RRSV were discussed...
  26. Chen Z, Yin C, Liu J, Zeng M, Wang Z, Yu D, et al. Methodology for antibody preparation and detection of southern rice black-streaked dwarf virus. Arch Virol. 2012;157:2327-33 pubmed publisher
    Southern rice black-streaked dwarf virus (SRBSDV) is a member of the genus Fijivirus of the family Reoviridae that causes a devastating disease in rice...
  27. Twigger K, Roulstone V, Kyula J, Karapanagiotou E, Syrigos K, Morgan R, et al. Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway. BMC Cancer. 2012;12:368 pubmed publisher
    ..Further analysis of material from in vitro and clinical studies is ongoing in an attempt to shed further light on this issue. ..
  28. Kim M, Egan C, Alain T, Urbanski S, Lee P, Forsyth P, et al. Acquired resistance to reoviral oncolysis in Ras-transformed fibrosarcoma cells. Oncogene. 2007;26:4124-34 pubmed
    ..Therefore, even if resistance to reoviral oncolysis should arise in tumor cells in vivo, other therapeutic strategies may nevertheless remain effective. ..
  29. Mainou B, Dermody T. Src kinase mediates productive endocytic sorting of reovirus during cell entry. J Virol. 2011;85:3203-13 pubmed publisher
    ..Collectively, these data provide evidence that Src kinase is an important mediator of signaling events that regulate the appropriate sorting of reovirus particles in the endocytic pathway for disassembly and cell entry. ..
  30. Guo H, Sun X, Yan L, Shao L, Fang Q. The NS16 protein of aquareovirus-C is a fusion-associated small transmembrane (FAST) protein, and its activity can be enhanced by the nonstructural protein NS26. Virus Res. 2013;171:129-37 pubmed publisher
    Orthoreoviruses and aquareoviruses represent two different genera in the family Reoviridae, but they share many common characteristics in structural organization and pathogenesis...
  31. Kibenge M, Iwamoto T, Wang Y, Morton A, Godoy M, Kibenge F. Whole-genome analysis of piscine reovirus (PRV) shows PRV represents a new genus in family Reoviridae and its genome segment S1 sequences group it into two separate sub-genotypes. Virol J. 2013;10:230 pubmed publisher
    ..related to members of the genera Orthoreovirus and Aquareovirus and an unambiguous new genus within the family Reoviridae. The Canadian and Norwegian PRV strains are most divergent in the segment S1 and S4 encoded proteins...
  32. Broering T, Arnold M, Miller C, Hurt J, Joyce P, Nibert M. Carboxyl-proximal regions of reovirus nonstructural protein muNS necessary and sufficient for forming factory-like inclusions. J Virol. 2005;79:6194-206 pubmed
    ..The inclusion-forming 471-721 region of muNS was shown to provide a useful platform for the presentation of peptides for studies of protein-protein association through colocalization to factory-like inclusions in transfected cells...
  33. Sinha Datta U, Chavali V, Ghosh A. Molecular cloning and characterization of Antheraea mylitta cytoplasmic polyhedrosis virus polyhedrin gene and its variant forms. Biochem Biophys Res Commun. 2005;332:710-8 pubmed
  34. Shmulevitz M, Marcato P, Lee P. Unshackling the links between reovirus oncolysis, Ras signaling, translational control and cancer. Oncogene. 2005;24:7720-8 pubmed
    ..Defining the molecular mechanism of reovirus oncolysis will shed light on reovirus replication and important aspects of cellular transformation, Ras signaling cascades and regulation of protein translation...
  35. Wang Z, Fang S, Zhang Z, Han C, Li D, Yu J. Development of an ID-ELISA for the detection of Rice black-streaked dwarf virus in plants. J Virol Methods. 2006;134:61-5 pubmed
    ..Based on the results, we conclude that efficient and economic detection of RBSDV can be performed routinely using polyclonal antiserum against P10 expressed in prokaryotic cells...
  36. Fang Q, Shah S, Liang Y, Zhou Z. 3D reconstruction and capsid protein characterization of grass carp reovirus. Sci China C Life Sci. 2005;48:593-600 pubmed
    ..GCRV) is a relatively new virus first isolated in China and is a member of the Aquareovirus genus of the Reoviridae family...
  37. Guzm n F, Dist fano A, Arneodo J, Hopp H, Lenardon S, del Vas M, et al. Sequencing of the bicistronic genome segments S7 and S9 of Mal de Río Cuarto virus (Fijivirus, Reoviridae) completes the genome of this virus. Arch Virol. 2007;152:565-73 pubmed publisher
    ..The topology of the trees obtained using the complete nucleotide and amino acid sequences of MRCV S7 and MRCV S9 was consistent with the analysis of the other MRCV segments previously published...
  38. Supyani S, Hillman B, Suzuki N. Baculovirus expression of the 11 mycoreovirus-1 genome segments and identification of the guanylyltransferase-encoding segment. J Gen Virol. 2007;88:342-50 pubmed
  39. Li Y, Zhang J, Li Y, Tan L, Chen W, Luo H, et al. Phylogenetic analysis of Heliothis armigera cytoplasmic polyhedrosis virus type 14 and a series of dwarf segments found in the genome. J Gen Virol. 2007;88:991-7 pubmed
    ..Comparison of the proteins of HaCPV-14 with those of other members of the family Reoviridae suggests that S1 encodes an RNA-dependent RNA polymerase (RdRp), whilst S2 encodes a major capsid protein of the ..
  40. Coulibaly F, Chiu E, Ikeda K, Gutmann S, Haebel P, Schulze Briese C, et al. The molecular organization of cypovirus polyhedra. Nature. 2007;446:97-101 pubmed
    ..The structure suggests that polyhedra can serve as the basis for the development of robust and versatile nanoparticles for biotechnological applications such as microarrays and biopesticides...
  41. Dewitte Orr S, Leong J, Bols N. Induction of antiviral genes, Mx and vig-1, by dsRNA and Chum salmon reovirus in rainbow trout monocyte/macrophage and fibroblast cell lines. Fish Shellfish Immunol. 2007;23:670-82 pubmed
    ..These results suggest that Mx can be regulated differently in macrophages and fibroblasts...
  42. Shimizu T, Satoh K, Kikuchi S, Omura T. The repression of cell wall- and plastid-related genes and the induction of defense-related genes in rice plants infected with Rice dwarf virus. Mol Plant Microbe Interact. 2007;20:247-54 pubmed
  43. Liu H, Wei C, Zhong Y, Li Y. Rice black-streaked dwarf virus outer capsid protein P10 has self-interactions and forms oligomeric complexes in solution. Virus Res. 2007;127:34-42 pubmed
    ..other viral proteins and displayed the oligomeric nature common to all known second-layer protein units of the Reoviridae. A truncated P10 mutant encoding the first 230 N-terminal amino acids lost its ability to form trimers even ..
  44. Miyazaki N, Uehara Ichiki T, Xing L, Bergman L, Higashiura A, Nakagawa A, et al. Structural evolution of reoviridae revealed by oryzavirus in acquiring the second capsid shell. J Virol. 2008;82:11344-53 pubmed publisher
    ..The structure of Rice ragged stunt virus (RRSV), in the genus Oryzavirus of the family Reoviridae, is determined to show a core composed of capsid shell, clamps, and long turrets...
  45. Yoshii M, Shimizu T, Yamazaki M, Higashi T, Miyao A, Hirochika H, et al. Disruption of a novel gene for a NAC-domain protein in rice confers resistance to Rice dwarf virus. Plant J. 2009;57:615-25 pubmed publisher
    ..We propose that RIM1 functions as a host factor that is required for multiplication of RDV in rice...
  46. Holm G, Pruijssers A, Li L, Danthi P, Sherry B, Dermody T. Interferon regulatory factor 3 attenuates reovirus myocarditis and contributes to viral clearance. J Virol. 2010;84:6900-8 pubmed publisher
    ..Thus, IRF-3 serves to facilitate virus clearance and prevent tissue injury in response to reovirus infection. ..
  47. Kim M, Williamson C, Prudhomme J, Bebb D, Riabowol K, Lee P, et al. The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status. Oncogene. 2010;29:3990-6 pubmed publisher
    ..Thus, oncolysis by these viruses may be influenced by both oncogenic activation and tumor suppressor status...
  48. Comins C, Spicer J, Protheroe A, Roulstone V, Twigger K, White C, et al. REO-10: a phase I study of intravenous reovirus and docetaxel in patients with advanced cancer. Clin Cancer Res. 2010;16:5564-72 pubmed publisher
    ..A multicenter, phase I dose escalation study was designed to assess the safety of combining reovirus with docetaxel chemotherapy in patients with advanced cancer...
  49. Løvoll M, Wiik Nielsen J, Grove S, Wiik Nielsen C, Kristoffersen A, Faller R, et al. A novel totivirus and piscine reovirus (PRV) in Atlantic salmon (Salmo salar) with cardiomyopathy syndrome (CMS). Virol J. 2010;7:309 pubmed publisher
    ..In the present work we have studied whether PRV or other infectious agents may be involved in the etiology of CMS...
  50. Cheng L, Sun J, Zhang K, Mou Z, Huang X, Ji G, et al. Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping. Proc Natl Acad Sci U S A. 2011;108:1373-8 pubmed publisher
    The cytoplasmic polyhedrosis virus (CPV) from the family Reoviridae belongs to a subgroup of "turreted" reoviruses, in which the mRNA capping activity occurs in a pentameric turret...
  51. Wang Q, Tao T, Zhang Y, Wu W, Li D, Yu J, et al. Rice black-streaked dwarf virus P6 self-interacts to form punctate, viroplasm-like structures in the cytoplasm and recruits viroplasm-associated protein P9-1. Virol J. 2011;8:24 pubmed publisher
    Rice black-streaked dwarf virus (RBSDV), a member of the genus Fijivirus within the family Reoviridae, can infect several graminaceous plant species including rice, maize and wheat, and is transmitted by planthoppers...
  52. Wiik Nielsen C, Løvoll M, Sandlund N, Faller R, Wiik Nielsen J, Bang Jensen B. First detection of piscine reovirus (PRV) in marine fish species. Dis Aquat Organ. 2012;97:255-8 pubmed publisher
    ..The virus was found in few of the analyzed samples so there is probably a more complex relationship that involves several carriers and virus -reservoirs...
  53. Yang C, Ji G, Liu H, Zhang K, Liu G, Sun F, et al. Cryo-EM structure of a transcribing cypovirus. Proc Natl Acad Sci U S A. 2012;109:6118-23 pubmed publisher
    Double-stranded RNA viruses in the family Reoviridae are capable of transcribing and capping nascent mRNA within an icosahedral viral capsid that remains intact throughout repeated transcription cycles...
  54. Mainou B, Dermody T. Transport to late endosomes is required for efficient reovirus infection. J Virol. 2012;86:8346-58 pubmed publisher
    ..Thus, reovirus virions localize to early, late, and recycling endosomes during entry into host cells, but only those that traverse early and late endosomes yield a productive infection...
  55. Jia D, Chen H, Mao Q, Liu Q, Wei T. Restriction of viral dissemination from the midgut determines incompetence of small brown planthopper as a vector of Southern rice black-streaked dwarf virus. Virus Res. 2012;167:404-8 pubmed publisher
  56. Zhang S, Bonami J. Isolation and partial characterization of a new reovirus in the Chinese mitten crab, Eriocheir sinensis H Milne Edwards. J Fish Dis. 2012;35:733-9 pubmed publisher
    ..This virus (EsRV816) possesses all the characters of the members of the reoviridae family and could represent a new genus.
  57. Sun L, Xie L, Andika I, Tan Z, Chen J. Non-structural protein P6 encoded by rice black-streaked dwarf virus is recruited to viral inclusion bodies by binding to the viroplasm matrix protein P9-1. J Gen Virol. 2013;94:1908-16 pubmed publisher
    Like other members of the family Reoviridae, rice black-streaked dwarf virus (RBSDV, genus Fijivirus) is thought to replicate and assemble within cytoplasmic viral inclusion bodies, commonly called viroplasms...
  58. Campbell J, Schelling P, Wetzel J, Johnson E, Forrest J, Wilson G, et al. Junctional adhesion molecule a serves as a receptor for prototype and field-isolate strains of mammalian reovirus. J Virol. 2005;79:7967-78 pubmed
    ..Mapping of these residues onto the crystal structure of sigma1 identified regions of conservation and variability, suggesting a likely mode of JAM-A binding via a conserved surface at the base of the sigma1 head domain...
  59. Salsman J, Top D, Boutilier J, Duncan R. Extensive syncytium formation mediated by the reovirus FAST proteins triggers apoptosis-induced membrane instability. J Virol. 2005;79:8090-100 pubmed
  60. Zhu S, Gao F, Cao X, Chen M, Ye G, Wei C, et al. The rice dwarf virus P2 protein interacts with ent-kaurene oxidases in vivo, leading to reduced biosynthesis of gibberellins and rice dwarf symptoms. Plant Physiol. 2005;139:1935-45 pubmed publisher
    ..Moreover, P2 may provide a novel tool to investigate the regulation of GA metabolism for plant growth and development...
  61. Qiao J, Wang H, Kottke T, White C, Twigger K, Diaz R, et al. Cyclophosphamide facilitates antitumor efficacy against subcutaneous tumors following intravenous delivery of reovirus. Clin Cancer Res. 2008;14:259-69 pubmed publisher
    ..v. injected virus...
  62. Twigger K, Vidal L, White C, de Bono J, Bhide S, Coffey M, et al. Enhanced in vitro and in vivo cytotoxicity of combined reovirus and radiotherapy. Clin Cancer Res. 2008;14:912-23 pubmed publisher
    ..To test combination treatment schedules of reovirus and radiation in human and murine tumor cells in vitro and in vivo...
  63. Tan L, Zhang J, Li Y, Li Y, Jiang H, Cao X, et al. The complete nucleotide sequence of the type 5 Helicoverpa armigera cytoplasmic polyhedrosis virus genome. Virus Genes. 2008;36:587-93 pubmed publisher
    ..Although the nucleotide sequences of the HaCPV-5 segments S1-10 exhibit no significant similarity to other viruses, blast searches did reveal some similarities between predicted HaCPV-5 amino acid sequences and those of other viruses...
  64. Kobayashi T, Ooms L, Chappell J, Dermody T. Identification of functional domains in reovirus replication proteins muNS and mu2. J Virol. 2009;83:2892-906 pubmed publisher
  65. Prestwich R, Errington F, Steele L, Ilett E, Morgan R, Harrington K, et al. Reciprocal human dendritic cell-natural killer cell interactions induce antitumor activity following tumor cell infection by oncolytic reovirus. J Immunol. 2009;183:4312-21 pubmed publisher
    ..These findings suggest that reciprocal DC-NK cell interactions, following reovirus therapy, may play an important role in altering the immune milieu of the tumor microenvironment and mediating tumor regression...
  66. McDonald S, Tao Y, Patton J. The ins and outs of four-tunneled Reoviridae RNA-dependent RNA polymerases. Curr Opin Struct Biol. 2009;19:775-82 pubmed publisher
    RNA-dependent RNA polymerases (RdRps) of the segmented double-stranded (ds) RNA viruses of the Reoviridae family exhibit distinguishing structural elements, enabling the enzymes to function within the confines of a proteinaceous core ..
  67. Shao L, Fan C, Maj E, Fang Q. Molecular characterization of nonstructural protein NS38 of grass carp reovirus. Virol Sin. 2010;25:123-9 pubmed publisher
    ..The result reported in this study will provide evidence for further viral protein-protein and protein-RNA interaction in dsRNA viruses replication...
  68. Quito Avila D, Jelkmann W, Tzanetakis I, Keller K, Martin R. Complete sequence and genetic characterization of Raspberry latent virus, a novel member of the family Reoviridae. Virus Res. 2011;155:397-405 pubmed publisher
    ..State, USA and British Columbia, Canada was fully sequenced and found to be a novel member of the family Reoviridae. The virus was designated as Raspberry latent virus (RpLV) based on the fact that it is symptomless when present ..
  69. Chen J, Xiong J, Yang J, Mao Z, Chen X. Nucleotide sequences of four RNA segments of a reovirus isolated from the mud crab Scylla serrata provide evidence that this virus belongs to a new genus in the family Reoviridae. Arch Virol. 2011;156:523-8 pubmed publisher
    ..Based on these observations, we propose that SsRV should be considered a member of a new genus in the family Reoviridae.
  70. Yu X, Ge P, Jiang J, Atanasov I, Zhou Z. Atomic model of CPV reveals the mechanism used by this single-shelled virus to economically carry out functions conserved in multishelled reoviruses. Structure. 2011;19:652-61 pubmed publisher
    Unlike the multishelled viruses in the Reoviridae, cytoplasmic polyhedrosis virus (CPV) is single shelled, yet stable and fully capable of carrying out functions conserved within Reoviridae. Here, we report a 3...
  71. Shimizu T, Nakazono Nagaoka E, Akita F, Uehara Ichiki T, Omura T, Sasaya T. Immunity to Rice black streaked dwarf virus, a plant reovirus, can be achieved in rice plants by RNA silencing against the gene for the viroplasm component protein. Virus Res. 2011;160:400-3 pubmed publisher
  72. Ye X, Tian Y, Deng G, Chi Y, Jiang X. Complete genomic sequence of a reovirus isolated from grass carp in China. Virus Res. 2012;163:275-83 pubmed publisher
    ..Phylogenetic analysis of coat proteins belonging to Reoviridae, VP1-VP6, showed that GCRV-GD108 clustered with AQRVs and grouped with ORVs, suggesting that GCRV-GD108 belonged ..
  73. Jia D, Chen H, Zheng A, Chen Q, Liu Q, Xie L, et al. Development of an insect vector cell culture and RNA interference system to investigate the functional role of fijivirus replication protein. J Virol. 2012;86:5800-7 pubmed publisher
    ..This system, combining insect vector cell culture and RNA interference, can further advance our understanding of the biological activities of fijivirus replication proteins...
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    Rice dwarf virus (RDV), a member of the family Reoviridae, has a 12-segmented dsRNA genome. Seven segments, designated S1, S2, S3, S5, S7, S8, and S9, encode structural proteins, while the remainder encode nonstructural proteins...
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    ..The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs...