encephalomyocarditis virus

Summary

Summary: The type species of CARDIOVIRUS causing encephalomyelitis and myocarditis in rodents, pigs, and monkeys. Infection in man has been reported with CNS involvement but without myocarditis.

Top Publications

  1. Eldin P, Papon L, Oteiza A, Brocchi E, Lawson T, Mechti N. TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. J Gen Virol. 2009;90:536-45 pubmed publisher
    ..We demonstrate that TRIM22 expression leads to a viral protection of HeLa cells against encephalomyocarditis virus infections...
  2. Steer S, Moran J, Christmann B, Maggi L, Corbett J. Role of MAPK in the regulation of double-stranded RNA- and encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. J Immunol. 2006;177:3413-20 pubmed
    ..Recently, we have shown that NF-kappaB is required for encephalomyocarditis virus (EMCV)- and dsRNA-stimulated COX-2 expression in mouse macrophages...
  3. Steer S, Moran J, Maggi L, Buller R, Perlman H, Corbett J. Regulation of cyclooxygenase-2 expression by macrophages in response to double-stranded RNA and viral infection. J Immunol. 2003;170:1070-6 pubmed
    ..Similar to dsRNA, encephalomyocarditis virus (EMCV) infection of RAW 264.7 cells stimulates COX-2 expression and PGE(2) accumulation...
  4. Kluivers M, Maurice H, Vyt P, Koenen F, Nielen M. Transmission of encephalomyocarditis virus in pigs estimated from field data in Belgium by means of R0. Vet Res. 2006;37:757-66 pubmed
    ..Preventing viral spread should therefore be focussed on rodent control instead of reduction of contact between pigs...
  5. An D, Jeong W, Jeoung H, Yoon S, Kim H, Choi C, et al. Encephalomyocarditis in Korea: serological survey in pigs and phylogenetic analysis of two historical isolates. Vet Microbiol. 2009;137:37-44 pubmed publisher
    ..3315 pigs from 363 farms located throughout all nine Korean provinces were tested for the presence of encephalomyocarditis virus (EMCV) antibodies using the virus neutralization test...
  6. Lawson T, Gronros D, Evans P, Bastien M, Michalewich K, Clark J, et al. Identification and characterization of a protein destruction signal in the encephalomyocarditis virus 3C protease. J Biol Chem. 1999;274:9871-80 pubmed
    ..structure, has been identified as a protein destruction signal in the rapidly degraded encephalomyocarditis virus 3C protease...
  7. Kassimi L, Boutrouille A, Gonzague M, Mbanda A, Cruciere C. Nucleotide sequence and construction of an infectious cDNA clone of an EMCV strain isolated from aborted swine fetus. Virus Res. 2002;83:71-87 pubmed
    A full-length cDNA clone of an Encephalomyocarditis virus (EMCV) strain (2887A) isolated from aborted swine fetus was constructed and sequenced...
  8. Kim Y, Jang S. Continuous heat shock enhances translational initiation directed by internal ribosomal entry site. Biochem Biophys Res Commun. 2002;297:224-31 pubmed
    ..Interestingly, heat stress also enhanced the viral IRES-dependent translation of encephalomyocarditis virus and hepatitis C virus but not poliovirus...
  9. Ng C, Jogi M, Yoo J, Onomoto K, Koike S, Iwasaki T, et al. Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses. J Virol. 2013;87:9511-22 pubmed publisher
    ..We focused on encephalomyocarditis virus (EMCV) infection, which exhibited transient SG formation...

More Information

Publications101 found, 100 shown here

  1. Gingras A, Svitkin Y, Belsham G, Pause A, Sonenberg N. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc Natl Acad Sci U S A. 1996;93:5578-83 pubmed
    Infection of cells with picornaviruses, such as poliovirus and encephalomyocarditis virus (EMCV), causes a shutoff of host protein synthesis...
  2. Kolupaeva V, Lomakin I, Pestova T, Hellen C. Eukaryotic initiation factors 4G and 4A mediate conformational changes downstream of the initiation codon of the encephalomyocarditis virus internal ribosomal entry site. Mol Cell Biol. 2003;23:687-98 pubmed
    Initiation of translation of encephalomyocarditis virus mRNA is mediated by an internal ribosome entry site (IRES) comprising structural domains H, I, J-K, and L immediately upstream of the initiation codon AUG at nucleotide 834 (AUG834)...
  3. Matsumori A, Nunokawa Y, Yamaki A, Yamamoto K, Hwang M, Miyamoto T, et al. Suppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF-kappaB inhibitor. Eur J Heart Fail. 2004;6:137-44 pubmed
  4. Fensterl V, White C, Yamashita M, Sen G. Novel characteristics of the function and induction of murine p56 family proteins. J Virol. 2008;82:11045-53 pubmed publisher
    ..However, in kidney mesangial cells, as opposed to podocytes, encephalomyocarditis virus, vesicular stomatitis virus, or extracellular dsRNA did not induce any of the p56 family proteins, ..
  5. Groppo R, Brown B, Palmenberg A. Mutational analysis of the EMCV 2A protein identifies a nuclear localization signal and an eIF4E binding site. Virology. 2011;410:257-67 pubmed publisher
    Cardioviruses have a unique 2A protein (143 aa). During genome translation, the encephalomyocarditis virus (EMCV) 2A is released through a ribosome skipping event mitigated through C-terminal 2A sequences and by subsequent N-terminal ..
  6. Maheshwari R, Srikantan V, Bhartiya D. Chloroquine enhances replication of Semliki Forest virus and encephalomyocarditis virus in mice. J Virol. 1991;65:992-5 pubmed
    ..This study demonstrates for the first time that CHL indeed enhances Semliki Forest virus and encephalomyocarditis virus replication in mice...
  7. Takeda M, Miura R, Shiota K, Hirasawa K, Lee M, Itagaki S, et al. Distribution of viral RNA in the spinal cord of DBA/2 mice developing biphasic paralysis following infection with the D variant of encephalomyocarditis virus (EMC-D). Int J Exp Pathol. 1995;76:441-7 pubmed
    DBA/2 mice infected with the D variant of encephalomyocarditis virus (EMC-D) (10(1) PFU/head) developed biphasic hind limb paralysis...
  8. Zhang G, Ge X, Guo X, Yang H. Genomic analysis of two porcine encephalomyocarditis virus strains isolated in China. Arch Virol. 2007;152:1209-13 pubmed
    Two strains of encephalomyocarditis virus (EMCV), designated BJC3 and HB1, were isolated from an aborted fetus and the heart tissue of a dead piglet that had pericardial fluid, respectively...
  9. Doi K. Experimental encephalomyocarditis virus infection in small laboratory rodents. J Comp Pathol. 2011;144:25-40 pubmed publisher
    b>Encephalomyocarditis virus (EMCV) is a cardiovirus that belongs to the family Picornaviridae. EMCV is an important cause of acute myocarditis in piglets and of fetal death or abortion in pregnant sows...
  10. Jones P, Mahamba C, Rest J, André C. Fatal inflammatory heart disease in a bonobo (Pan paniscus). J Med Primatol. 2005;34:45-9 pubmed
    We report the first probable identification of encephalomyocarditis virus (EMCV) in a bonobo (Pan paniscus) that had been part of a forest re-introduction programme...
  11. Tsen K, Tsen S, Fu Q, Lindsay S, Li Z, Cope S, et al. Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: insight into the possible inactivation mechanisms. J Biomed Opt. 2011;16:078003 pubmed publisher
    We report experimental results on the inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by a visible femtosecond laser...
  12. Carocci M, Cordonnier N, Huet H, Romey A, Relmy A, Gorna K, et al. Encephalomyocarditis virus 2A protein is required for viral pathogenesis and inhibition of apoptosis. J Virol. 2011;85:10741-54 pubmed publisher
    The encephalomyocarditis virus (EMCV), a Picornaviridae virus, has a wide host spectrum and can cause various diseases. EMCV virulence factors, however, are as yet ill defined...
  13. Exley M, Bigley N, Cheng O, Shaulov A, Tahir S, Carter Q, et al. Innate immune response to encephalomyocarditis virus infection mediated by CD1d. Immunology. 2003;110:519-26 pubmed
    ..The role of the CD1d system was assessed during infection with encephalomyocarditis virus (EMCV-D), a picornavirus that causes acute diabetes, paralysis and myocarditis...
  14. Yoon J, Jun H. Viruses cause type 1 diabetes in animals. Ann N Y Acad Sci. 2006;1079:138-46 pubmed
    ..This results in the breakdown of the immune balance, contributing to the development of diabetes in KRV-infected DR-BB rats. ..
  15. Groppo R, Palmenberg A. Cardiovirus 2A protein associates with 40S but not 80S ribosome subunits during infection. J Virol. 2007;81:13067-74 pubmed publisher
    ..This study examined alterations in the cellular translational components in HeLa cells infected with encephalomyocarditis virus (EMCV), a cardiovirus...
  16. Oberste M, Gotuzzo E, Blair P, Nix W, Ksiazek T, Comer J, et al. Human febrile illness caused by encephalomyocarditis virus infection, Peru. Emerg Infect Dis. 2009;15:640-6 pubmed publisher
    ..Virus isolated in Vero E6 cells was identified as encephalomyocarditis virus (EMCV) by electron microscopy and by subsequent molecular diagnostic testing of samples from 2 febrile ..
  17. Porter F, Palmenberg A. Leader-induced phosphorylation of nucleoporins correlates with nuclear trafficking inhibition by cardioviruses. J Virol. 2009;83:1941-51 pubmed publisher
    ..We have shown that L from encephalomyocarditis virus (EMCV) binds and inhibits the activity of Ran-GTPase, a key regulator of nucleocytoplasmic transport...
  18. Clark A, Robertson M, Conn G, Belsham G. Conserved nucleotides within the J domain of the encephalomyocarditis virus internal ribosome entry site are required for activity and for interaction with eIF4G. J Virol. 2003;77:12441-9 pubmed
    The internal ribosome entry site (IRES) elements of cardioviruses (e.g., encephalomyocarditis virus [EMCV] and foot-and-mouth disease virus) are predicted to have very similar secondary structures...
  19. Papon L, Oteiza A, Imaizumi T, Kato H, Brocchi E, Lawson T, et al. The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection. Virology. 2009;393:311-8 pubmed publisher
    ..In this report, we demonstrate that RIG-I is degraded during encephalomyocarditis virus (EMCV) infection. This effect is mediated by both the viral-encoded 3C protease and caspase proteinase...
  20. Takeda M, Ohtsuka R, Nakayama Y, Doi K. The role of CD4(+) T cells in biphasic hind limb paralysis induced by the D variant of encephalomyocarditis virus (EMC-D) in DBA/2 mice. Exp Anim. 2004;53:31-5 pubmed
    DBA/2 CrSlc mice infected with the D variant of encephalomyocarditis virus (EMC-D) (10 PFU/head) developed biphasic hind limb paralysis due to spinal cord lesion...
  21. Wang J, Meissner A, Malek S, Chen Y, Ke Q, Zhang J, et al. Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis. Am J Physiol Heart Circ Physiol. 2005;289:H1577-83 pubmed
    ..BALB/c mice were inoculated with the encephalomyocarditis virus (EMCV) or sham inoculated with saline and followed for 30 days...
  22. Choi K, Jun H, Kim H, Park H, Eom Y, Noh H, et al. Role of Hck in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J Virol. 2001;75:1949-57 pubmed
  23. Psalla D, Psychas V, Spyrou V, Billinis C, Papaioannou N, Vlemmas I. Pathogenesis of experimental encephalomyocarditis: a histopathological, immunohistochemical and virological study in rats. J Comp Pathol. 2006;134:30-9 pubmed
    ..infected, either by oronasal inoculation or by contact, with one of two different myocardial strains of encephalomyocarditis virus (EMCV), namely, the Greek strain 424/90 and the Belgian strain B279/95...
  24. Bergamini G, Preiss T, Hentze M. Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system. RNA. 2000;6:1781-90 pubmed
    ..We show that translation driven by the IRESs of poliovirus (PV), encephalomyocarditis virus (EMCV), and hepatitis A virus is also significantly augmented by a poly(A) tail, ranging from an ..
  25. Svitkin Y, Sonenberg N. Cell-free synthesis of encephalomyocarditis virus. J Virol. 2003;77:6551-5 pubmed
    We developed a system for complete replication of encephalomyocarditis virus (EMCV) in a test tube by using an in vitro translation extract from Krebs-2 cells...
  26. Canelli E, Luppi A, Lavazza A, Lelli D, Sozzi E, Martin A, et al. Encephalomyocarditis virus infection in an Italian zoo. Virol J. 2010;7:64 pubmed publisher
    A fatal Encephalomyocarditis virus (EMCV) infection epidemic involving fifteen primates occurred between October 2006 and February 2007 at the Natura Viva Zoo...
  27. Martin L, Neal Z, McBride M, Palmenberg A. Mengovirus and encephalomyocarditis virus poly(C) tract lengths can affect virus growth in murine cell culture. J Virol. 2000;74:3074-81 pubmed
    ..The characterized cultures should provide excellent tools for molecular study of poly(C) tract-mediated virulence. ..
  28. Chen Z, Guo X, Ge X, Jia H, Yang H. Protective immune response in mice vaccinated with a recombinant adenovirus containing capsid precursor polypeptide P1, nonstructural protein 2A and 3C protease genes (P12A3C) of encephalomyocarditis virus. Vaccine. 2008;26:573-80 pubmed
    b>Encephalomyocarditis virus (EMCV) infection can cause acute myocarditis and sudden death in pre-weaned piglets as well as severe reproductive failure in sows...
  29. Gitlin L, Barchet W, Gilfillan S, Cella M, Beutler B, Flavell R, et al. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A. 2006;103:8459-64 pubmed
    ..Moreover, mda-5-/- mice exhibited a selectively impaired antiviral response to encephalomyocarditis picornavirus, indicating functional specialization of mda-5 in vivo...
  30. El McHichi B, Regad T, Maroui M, Rodriguez M, Aminev A, Gerbaud S, et al. SUMOylation promotes PML degradation during encephalomyocarditis virus infection. J Virol. 2010;84:11634-45 pubmed publisher
    ..show here that primary fibroblasts derived from PML knockout mice are more sensitive to infection with encephalomyocarditis virus (EMCV), suggesting that the absence of PML results in an increase in EMCV replication...
  31. Czechowicz J, Huaman J, Forshey B, Morrison A, Castillo R, Huaman A, et al. Prevalence and risk factors for encephalomyocarditis virus infection in Peru. Vector Borne Zoonotic Dis. 2011;11:367-74 pubmed publisher
    Although encephalomyocarditis virus (EMCV) infection has been commonly documented among domestic animals, less is known about EMCV transmission among humans. Recently, we described the isolation of EMCV from two febrile patients in Peru...
  32. Borovjagin A, Ezrokhi M, Rostapshov V, Ugarova TYu -, Bystrova T, Shatsky I. RNA--protein interactions within the internal translation initiation region of encephalomyocarditis virus RNA. Nucleic Acids Res. 1991;19:4999-5005 pubmed
    Various derivatives of the internal ribosomal entry site (IRES) of encephalomyocarditis virus (EMCV) RNA have been used to analyze by UV-cross-linking its interaction with mRNA binding proteins from ascites carcinoma Krebs-2 cells...
  33. Kaminski A, Jackson R. The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute. RNA. 1998;4:626-38 pubmed
    ..It is shown here that for encephalomyocarditis virus (EMCV), the PTB dependence of IRES function in vitro is determined partly by the nature of the reporter ..
  34. Kishimoto C, Kawamata H, Sakai S, Shinohara H, Ochiai H. Enhanced production of macrophage inflammatory protein 2 (MIP-2) by in vitro and in vivo infections with encephalomyocarditis virus and modulation of myocarditis with an antibody against MIP-2. J Virol. 2001;75:1294-300 pubmed
    ..MIP-2 is an important naturally occurring inflammatory cytokine in myocarditis, and anti-MIP-2 MAb treatment may prevent the inflammatory response. ..
  35. Maggi L, Moran J, Buller R, Corbett J. ERK activation is required for double-stranded RNA- and virus-induced interleukin-1 expression by macrophages. J Biol Chem. 2003;278:16683-9 pubmed
    ..These findings support a novel PKR-independent role for ERK in the regulation of the antiviral response of IL-1 expression and release by macrophages. ..
  36. Kawamoto S, Oritani K, Asada H, Takahashi I, Ishikawa J, Yoshida H, et al. Antiviral activity of limitin against encephalomyocarditis virus, herpes simplex virus, and mouse hepatitis virus: diverse requirements by limitin and alpha interferon for interferon regulatory factor 1. J Virol. 2003;77:9622-31 pubmed
    ..Limitin inhibited not only cytopathic effects in encephalomyocarditis virus- or herpes simplex virus (HSV) type 1-infected L929 cells, but also plaque formation in mouse hepatitis ..
  37. Papaioannou N, Billinis C, Psychas V, Papadopoulos O, Vlemmas I. Pathogenesis of encephalomyocarditis virus (EMCV) infection in piglets during the viraemia phase: a histopathological, immunohistochemical and virological study. J Comp Pathol. 2003;129:161-8 pubmed
    ..were inoculated oranasally with 5 ml of a suspension (10(6) TCID(50)/ml) of a Greek myocardial strain of encephalomyocarditis virus (EMCV)...
  38. Yamanouchi Ueno A, Nakayama Y, Doi K. Characteristics of testicular lesions in mice infected with a low dose of encephalomyocarditis (EMC) virus. Exp Mol Pathol. 2004;77:72-6 pubmed
    ..The present results suggest that macrophages may play an important role in the development of testicular lesions induced in mice with a low dose of EMC-D. ..
  39. Ank N, West H, Bartholdy C, Eriksson K, Thomsen A, Paludan S. Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo. J Virol. 2006;80:4501-9 pubmed
    ..In vitro assays revealed that IFN-lambdas have appreciable antiviral activity against encephalomyocarditis virus (EMCV) but limited activity against herpes simplex virus type 2 (HSV-2), whereas IFN-alpha potently ..
  40. Li J, Zhang C, Jostock T, Dubel S. Analysis of IgG heavy chain to light chain ratio with mutant Encephalomyocarditis virus internal ribosome entry site. Protein Eng Des Sel. 2007;20:491-6 pubmed
    ..To circumvent this problem, a series of Encephalomyocarditis virus internal ribosome entry site (EMCV IRES) variants with different translation efficiencies were created ..
  41. Billinis C. Encephalomyocarditis virus infection in wildlife species in Greece. J Wildl Dis. 2009;45:522-6 pubmed
    The objective of this work was to search for potential wildlife reservoir hosts of Encephalomyocarditis virus (EMCV) in wildlife species. From 1994 to 2006, 317 blood and tissue samples were collected from 17 wildlife species in Greece...
  42. Freudenburg W, Moran J, Lents N, Baldassare J, Buller R, Corbett J. Phosphatidylinositol 3-kinase regulates macrophage responses to double-stranded RNA and encephalomyocarditis virus. J Innate Immun. 2010;2:77-86 pubmed publisher
    ..When macrophages are infected with encephalomyocarditis virus (EMCV) there is a rapid and transient activation of PI3K and phosphorylation of its downstream target ..
  43. Jeoung H, Lee W, Jeong W, Ko Y, Choi C, An D. Immune responses and expression of the virus-like particle antigen of the porcine encephalomyocarditis virus. Res Vet Sci. 2010;89:295-300 pubmed publisher
    ..To express VLPs of the porcine encephalomyocarditis virus (EMCV) and investigate their efficacy and immuno response in vivo, a plasmid (P12A3C-pCI) containing the ..
  44. Freudenburg W, Buller R, Corbett J. Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. J Gen Virol. 2010;91:2278-85 pubmed publisher
    ..In this study, the role of SFK activation in the inflammatory response of macrophages to encephalomyocarditis virus (EMCV) infection was examined...
  45. Rajan J, Rodriguez D, Miao E, Aderem A. The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection. J Virol. 2011;85:4167-72 pubmed publisher
    ..We show here that two other RNA viruses, encephalomyocarditis virus (EMCV) and vesicular stomatitis virus (VSV), activate the NLRP3 inflammasome in dendritic cells and ..
  46. Zhang Y, Li Z, Ge X, Guo X, Yang H. Autophagy promotes the replication of encephalomyocarditis virus in host cells. Autophagy. 2011;7:613-28 pubmed
    ..However, to date, it is unknown whether autophagy is activated in encephalomyocarditis virus (EMCV)-infected host cells, and if so, what its role is in this process...
  47. Ito M, Yanagi Y, Ichinohe T. Encephalomyocarditis virus viroporin 2B activates NLRP3 inflammasome. PLoS Pathog. 2012;8:e1002857 pubmed publisher
    ..Here, we demonstrate that encephalomyocarditis virus (EMCV), a positive strand RNA virus of the family Picornaviridae, activates the NLRP3 inflammasome in ..
  48. Nakano A, Matsumori A, Kawamoto S, Tahara H, Yamato E, Sasayama S, et al. Cytokine gene therapy for myocarditis by in vivo electroporation. Hum Gene Ther. 2001;12:1289-97 pubmed
    ..Four-week-old male DBA/2 mice were inoculated intraperitoneally with 10 PFU of encephalomyocarditis virus. Immediately after virus inoculation, an expression plasmid carrying IL-1ra or vIL-10 was injected into ..
  49. Nishio R, Shioi T, Sasayama S, Matsumori A. Carvedilol increases the production of interleukin-12 and interferon-gamma and improves the survival of mice infected with the encephalomyocarditis virus. J Am Coll Cardiol. 2003;41:340-5 pubmed
    ..was designed to examine the effects of carvedilol in a murine model of viral myocarditis induced by encephalomyocarditis virus (EMCV) infection. Cytokines play an important role in the pathophysiology of viral myocarditis...
  50. Maurice H, Nielen M, Brocchi E, Nowotny N, Kassimi L, Billinis C, et al. The occurrence of encephalomyocarditis virus (EMCV) in European pigs from 1990 to 2001. Epidemiol Infect. 2005;133:547-57 pubmed
    The occurrence of encephalomyocarditis virus (EMCV) among domestic pigs and wild boar in several European countries is described and discussed...
  51. Hammoumi S, Cruciere C, Guy M, Boutrouille A, Messiaen S, Lecollinet S, et al. Characterization of a recombinant encephalomyocarditis virus expressing the enhanced green fluorescent protein. Arch Virol. 2006;151:1783-96 pubmed
    A recombinant encephalomyocarditis virus (rEMCV2887A-egfp) expressing the enhanced green fluorescent protein (EGFP) was produced...
  52. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006;441:101-5 pubmed
    ..Together, our data show that RIG-I and MDA5 distinguish different RNA viruses and are critical for host antiviral responses. ..
  53. Guy M, Chilmonczyk S, Cruciere C, Eloit M, Bakkali Kassimi L. Efficient infection of buffalo rat liver-resistant cells by encephalomyocarditis virus requires binding to cell surface sialic acids. J Gen Virol. 2009;90:187-96 pubmed publisher
    ..of virus and cell lysis seen in baby hamster kidney cells (BHK-21) infected with the strain 1086C of encephalomyocarditis virus (EMCV), in buffalo rat liver cells (BRL) neither virus replication nor cytopathic effects were observed...
  54. Gasparian A, Neznanov N, Jha S, Galkin O, Moran J, Gudkov A, et al. Inhibition of encephalomyocarditis virus and poliovirus replication by quinacrine: implications for the design and discovery of novel antiviral drugs. J Virol. 2010;84:9390-7 pubmed publisher
    ..Here, we show that QC suppresses translation directed by the encephalomyocarditis virus (EMCV) and poliovirus IRESs in a cell-free system and in virus-infected HeLa cells...
  55. Masek Hammerman K, Miller A, Lin K, Mackey J, Weissenbock H, Gierbolini L, et al. Epizootic myocarditis associated with encephalomyocarditis virus in a group of rhesus macaques (Macaca mulatta). Vet Pathol. 2012;49:386-92 pubmed publisher
    Six cases of fatal myocarditis associated with encephalomyocarditis virus occurred over a 14-month period in a group of outdoor-housed juvenile rhesus macaques...
  56. Hammoumi S, Guy M, Eloit M, Bakkali Kassimi L. Encephalomyocarditis virus may use different pathways to initiate infection of primary human cardiomyocytes. Arch Virol. 2012;157:43-52 pubmed publisher
    b>Encephalomyocarditis virus (EMCV) can infect a wide range of vertebrate species including swine and non-human primates, but few data are available for humans...
  57. Rice A, Duncan R, Hershey J, Kerr I. Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells. J Virol. 1985;54:894-8 pubmed
    ..kinase was monitored in monolayer cultures of control and interferon-treated HeLa cells infected with encephalomyocarditis virus. The extent of phosphorylation in the intact cell of the alpha-subunit of eucaryotic protein synthesis ..
  58. de Felipe P, Izquierdo M. Tricistronic and tetracistronic retroviral vectors for gene transfer. Hum Gene Ther. 2000;11:1921-31 pubmed
    ..foot-and-mouth disease virus (FMDV) 2A sequence and the internal ribosome entry sites (IRESes) from encephalomyocarditis virus (ECMV) and avian reticuloendotheliosis virus type A (REV-A) to construct tricistronic and tetracistronic ..
  59. Svitkin Y, Imataka H, Khaleghpour K, Kahvejian A, Liebig H, Sonenberg N. Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation. RNA. 2001;7:1743-52 pubmed
    ..The elF4G cleavage-induced loss of the stimulatory effect of poly(A) on translation was mimicked by the addition of the C-terminal portion of elF4G. Thus, PABP stimulates picornavirus translation through its interaction with elF4G. ..
  60. Phelan M, Banks R, Conn G, Ramesh V. NMR studies of the structure and Mg2+ binding properties of a conserved RNA motif of EMCV picornavirus IRES element. Nucleic Acids Res. 2004;32:4715-24 pubmed
    ..binding properties of a conserved 75mer RNA motif of the internal ribosome entry site (IRES) element of encephalomyocarditis virus picornavirus have been investigated by (1)H-NMR and UV melting experiments...
  61. Ohguchi A, Nakayama Y, Yasoshima A, Doi C, Mikami T, Uetsuka K, et al. Encepalomyocarditis virus-induced apoptosis and ultrastructural changes in the lacrimal and parotid glands of mice. Exp Mol Pathol. 2006;80:201-7 pubmed
    ..In conclusion, between the exorbital lacrimal and parotid glands, there was a reverse relationship observed between the development of acinar cell apoptosis and that of total damage of acinar cells. ..
  62. Mujtaba M, Patel C, Patel R, Flowers L, Burkhart M, Waiboci L, et al. The gamma interferon (IFN-gamma) mimetic peptide IFN-gamma (95-133) prevents encephalomyocarditis virus infection both in tissue culture and in mice. Clin Vaccine Immunol. 2006;13:944-52 pubmed
  63. McLelland D, Kirkland P, Rose K, Dixon R, Smith N. Serologic responses of Barbary sheep (Ammotragus lervia), Indian antelope (Antilope cervicapra), wallaroos (Macropus robustus), and chimpanzees (Pan troglodytes) to an inactivated encephalomyocarditis virus vaccine. J Zoo Wildl Med. 2005;36:69-73 pubmed
    b>Encephalomyocarditis virus (EMCV) is a picornavirus with a worldwide distribution, capable of infecting a wide range of species...
  64. Sanz M, Castello A, Carrasco L. Viral translation is coupled to transcription in Sindbis virus-infected cells. J Virol. 2007;81:7061-8 pubmed
    ..Finally, a similar behavior was observed for other RNA viruses, such as vesicular stomatitis virus and encephalomyocarditis virus. These findings support the notion that translation is coupled to transcription in cells infected with ..
  65. Higuchi H, Hara M, Yamamoto K, Miyamoto T, Kinoshita M, Yamada T, et al. Mast cells play a critical role in the pathogenesis of viral myocarditis. Circulation. 2008;118:363-72 pubmed publisher
    ..W/W(V)) and WCB6F1-Kitl(Sl)/Kitl(Sl-d) (Sl/Sl(d)), were inoculated with 10 plaque-forming units of the encephalomyocarditis virus intraperitoneally...
  66. Zhu S, Ge X, Gong X, Guo X, Chen Y, Yang H. Alteration of encephalomyocarditis virus pathogenicity due to a mutation at position 100 of VP1. Sci China Life Sci. 2011;54:535-43 pubmed publisher
    b>Encephalomyocarditis virus (EMCV) infection leads to many diseases including encephalitis, myocarditis and diabetes in its natural host, the mouse. In this study, we generated four cDNA clones with a point mutation at position 100 of VP1...
  67. Duke G, Palmenberg A. Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts. J Virol. 1989;63:1822-6 pubmed
  68. Brown E, Zajac A, Lemon S. In vitro characterization of an internal ribosomal entry site (IRES) present within the 5' nontranslated region of hepatitis A virus RNA: comparison with the IRES of encephalomyocarditis virus. J Virol. 1994;68:1066-74 pubmed
    ..was compared with results for monocistronic constructs containing the IRES of the more rapidly growing encephalomyocarditis virus (EMCV)...
  69. Kolupaeva V, Hellen C, Shatsky I. Structural analysis of the interaction of the pyrimidine tract-binding protein with the internal ribosomal entry site of encephalomyocarditis virus and foot-and-mouth disease virus RNAs. RNA. 1996;2:1199-212 pubmed
    ..This process is exemplified by encephalomyocarditis virus (EMCV), which contains an internal ribosomal entry site (IRES) within its 5' nontranslated region that ..
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    ..found that CD1d-reactive T cells mediate to resistance against the acute, cytopathic virus diabetogenic encephalomyocarditis virus (EMCV-D) in relatively Th1-biased, C57BL/6-based backgrounds...
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  87. Schwarz E, Badorff C, Hiura T, Wessely R, Badorff A, Verma I, et al. NF-kappaB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout mice. J Virol. 1998;72:5654-60 pubmed
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    ..infected, either by oronasal inoculation or by contact, with one of two different myocardial strains of encephalomyocarditis virus (EMCV), namely, the Greek strain 424/90 and the Belgian strain B279/95...
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    ..Inactivation of NF-kappaB attenuates encephalomyocarditis virus (EMCV) virulence by triggering rapid apoptosis of infected cells, thereby pre-emptively limiting viral ..