cardiovirus

Summary

Summary: A genus of the family PICORNAVIRIDAE causing encephalitis and myocarditis in rodents. ENCEPHALOMYOCARDITIS VIRUS is the type species.

Top Publications

  1. Zoll J, Erkens Hulshof S, Lanke K, Verduyn Lunel F, Melchers W, Schoondermark van de Ven E, et al. Saffold virus, a human Theiler's-like cardiovirus, is ubiquitous and causes infection early in life. PLoS Pathog. 2009;5:e1000416 pubmed publisher
    ..In addition, this family contains a number of viruses that infect animals, including members of the genus Cardiovirus such as Encephalomyocarditis virus (EMCV) and Theiler's murine encephalomyelits virus (TMEV)...
  2. Nielsen A, Bottiger B, Banner J, Hoffmann T, Nielsen L. Serious invasive Saffold virus infections in children, 2009. Emerg Infect Dis. 2012;18:7-12 pubmed publisher
    The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV)...
  3. Chiu C, Greninger A, Chen E, Haggerty T, Parsonnet J, Delwart E, et al. Cultivation and serological characterization of a human Theiler's-like cardiovirus associated with diarrheal disease. J Virol. 2010;84:4407-14 pubmed publisher
    ..have identified human cardioviruses, including Saffold virus (SAFV) and a related virus named human TMEV-like cardiovirus (HTCV)...
  4. Loughran G, Firth A, Atkins J. Ribosomal frameshifting into an overlapping gene in the 2B-encoding region of the cardiovirus genome. Proc Natl Acad Sci U S A. 2011;108:E1111-9 pubmed publisher
    The genus Cardiovirus (family Picornaviridae) currently comprises the species Encephalomyocarditis virus (EMCV) and Theilovirus...
  5. Paul S, Michiels T. Cardiovirus leader proteins are functionally interchangeable and have evolved to adapt to virus replication fitness. J Gen Virol. 2006;87:1237-46 pubmed
    The leader (L) proteins encoded by picornaviruses of the genus Cardiovirus [Theiler's murine encephalomyelitis virus (TMEV) and Encephalomyocarditis virus (EMCV)] are small proteins thought to exert important functions in virus-host ..
  6. Blinkova O, Kapoor A, Victoria J, Jones M, Wolfe N, Naeem A, et al. Cardioviruses are genetically diverse and cause common enteric infections in South Asian children. J Virol. 2009;83:4631-41 pubmed publisher
    ..Cardioviruses have also been detected at lower frequencies in other mammals. The Cardiovirus genus within the Picornaviridae family is currently made up of two viral species, Theilovirus and ..
  7. Drexler J, Baumgarte S, Luna L, Stocker A, Almeida P, Ribeiro T, et al. Genomic features and evolutionary constraints in Saffold-like cardioviruses. J Gen Virol. 2010;91:1418-27 pubmed publisher
    ..Accordingly, the results of this study suggest that SLCV and TMEV may represent distinct species within the genus Cardiovirus.
  8. Drexler J, Luna L, Stocker A, Almeida P, Ribeiro T, Petersen N, et al. Circulation of 3 lineages of a novel Saffold cardiovirus in humans. Emerg Infect Dis. 2008;14:1398-405 pubmed publisher
    ..Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with ..
  9. Hertzler S, Liang Z, Treso B, Lipton H. Adaptation of Saffold virus 2 for high-titer growth in mammalian cells. J Virol. 2011;85:7411-8 pubmed publisher
    ..Intracerebral inoculation of 6-week-old FVB/n mice produced paralysis and acute neuropathological changes, including meningeal infiltrates, encephalitis, particularly of the limbic system, and spinal cord white matter inflammation. ..

More Information

Publications58

  1. Ren L, Gonzalez R, Xiao Y, Xu X, Chen L, Vernet G, et al. Saffold cardiovirus in children with acute gastroenteritis, Beijing, China. Emerg Infect Dis. 2009;15:1509-11 pubmed publisher
    To understand Saffold cardiovirus (SAFV) distribution, prevalence, and clinical relevance in China, we retrospectively studied SAFV in children with acute gastroenteritis and found SAFV in 12 (3.2%) of 373...
  2. Abed Y, Boivin G. New Saffold cardioviruses in 3 children, Canada. Emerg Infect Dis. 2008;14:834-6 pubmed publisher
    In Canada, cardiovirus isolates related to Saffold virus were detected in nasopharyngeal aspirates from 3 children with respiratory symptoms. Polyprotein sequence of the Can112051-06 isolate had 91...
  3. Ren L, Gonzalez R, Xie Z, Xiao Y, Li Y, Liu C, et al. Saffold cardioviruses of 3 lineages in children with respiratory tract infections, Beijing, China. Emerg Infect Dis. 2010;16:1158-61 pubmed publisher
    To clarify the potential for respiratory transmission of Saffold cardiovirus (SAFV) and characterize the pathogen, we analyzed respiratory specimens from 1,558 pediatric patients in Beijing. We detected SAFV in 7 (0...
  4. Lobert P, Escriou N, Ruelle J, Michiels T. A coding RNA sequence acts as a replication signal in cardioviruses. Proc Natl Acad Sci U S A. 1999;96:11560-5 pubmed
    Theiler's virus and Mengo virus are representatives of the Cardiovirus genus within the picornavirus family. Their genome is an 8-kilobase long positive strand RNA molecule...
  5. Vives Adrian L, Lujan C, Oliva B, van der Linden L, Selisko B, Coutard B, et al. The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site. J Virol. 2014;88:5595-607 pubmed publisher
    Encephalomyocarditis virus (EMCV) is a member of the Cardiovirus genus within the large Picornaviridae family, which includes a number of important human and animal pathogens...
  6. Himeda T, Hosomi T, Asif N, Shimizu H, Okuwa T, Muraki Y, et al. The preparation of an infectious full-length cDNA clone of Saffold virus. Virol J. 2011;8:110 pubmed publisher
    ..of Saffold virus (SAFV) among humans still remains unclear, although it was identified as a novel human cardiovirus in 2007...
  7. Himeda T, Ohara Y. Saffold virus, a novel human Cardiovirus with unknown pathogenicity. J Virol. 2012;86:1292-6 pubmed publisher
    Although cardioviruses have been thought to mainly infect rodents, a novel human cardiovirus, designated Saffold virus (SAFV), was identified in 2007...
  8. Blinkova O, Rosario K, Li L, Kapoor A, Slikas B, Bernardin F, et al. Frequent detection of highly diverse variants of cardiovirus, cosavirus, bocavirus, and circovirus in sewage samples collected in the United States. J Clin Microbiol. 2009;47:3507-13 pubmed publisher
    ..More frequent and deeper sampling of viral nucleic acids in sewage samples could be used to monitor changes in the prevalence and genetic composition of these and other novel enteric viruses. ..
  9. Ciomperlik J, Basta H, Palmenberg A. Three cardiovirus Leader proteins equivalently inhibit four different nucleocytoplasmic trafficking pathways. Virology. 2015;484:194-202 pubmed publisher
    b>Cardiovirus infections inhibit nucleocytoplasmic trafficking by Leader protein-induced phosphorylation of Phe/Gly-containing nucleoporins (Nups)...
  10. Dvorak C, Akkutay Yoldar Z, Stone S, Tousignant S, Vannucci F, Murtaugh M. An indirect enzyme-linked immunosorbent assay for the identification of antibodies to Senecavirus A in swine. BMC Vet Res. 2017;13:50 pubmed publisher
    ..genus Senecavirus, is a recently identified single-stranded RNA virus closely related to members of the Cardiovirus genus...
  11. Qian S, Fan W, Liu T, Wu M, Zhang H, Cui X, et al. Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage. J Virol. 2017;91: pubmed publisher
    ..Its nucleotide sequence is highly similar to those of members of the Cardiovirus genus...
  12. Lin T, Lin T, Chiu S, Huang Y, Ho C, Lee C, et al. Molecular epidemiological analysis of Saffold cardiovirus genotype 3 from upper respiratory infection patients in Taiwan. J Clin Virol. 2015;70:7-13 pubmed publisher
    Saffold cardiovirus (SAFV) belongs to the Cardiovirus genus of Picornaviridae family, and may be a relevant new human pathogen; Thus far, eleven genotypes have been identified...
  13. Tan S, Prabakaran M. Immunohistochemical insights into Saffold virus infection of the brain of juvenile AG129 mice. Virol J. 2016;13:191 pubmed
    Saffold Virus (SAFV) is a human cardiovirus that is suspected of causing infection of the central nervous system (CNS) in children...
  14. Wang Y, Zhao J, Zheng M, Liu Z, Li W, Fu X, et al. A novel cardiovirus in wild rats. Virol J. 2018;15:58 pubmed publisher
    ..Using viral metagenomics, we genetically characterized a novel cardiovirus (named SX1) from wild rat feces...
  15. Mullapudi E, Nováček J, Palkova L, Kulich P, Lindberg A, van Kuppeveld F, et al. Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3. J Virol. 2016;90:7628-39 pubmed publisher
    ..We address this gap in our current knowledge by studying the uncoating of the nonenveloped human cardiovirus Saffold virus 3 (SAFV-3) of the family Picornaviridae SAFVs cause diseases ranging from gastrointestinal ..
  16. Yuan W, Wang J, Xu F, Huang B, Lian Y, Rao D, et al. Development of a duplex real-time RT-PCR for the simultaneous detection and differentiation of Theiler's murine encephalomyelitis virus and rat theilovirus. J Virol Methods. 2016;236:139-146 pubmed publisher
    Theiler's murine encephalomyelitis virus (TMEV) and rat theilovirus (RTV), the member of the genus Cardiovirus, are widespread in laboratory mice and rats, and are potential contaminants of biological materials...
  17. Maciejewski S, Ullmer W, Semler B. VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage. Virology. 2018;516:139-146 pubmed publisher
    ..required during enterovirus infections, we determined if TDP2 is necessary during infection by the prototype cardiovirus, EMCV. We found that EMCV yields are reduced in the absence of TDP2...
  18. Kotani O, Suzuki T, Yokoyama M, Iwata Yoshikawa N, Nakajima N, Sato H, et al. Intracerebral inoculation of mouse-passaged Saffold virus type 3 affects cerebellar development in neonatal mice. J Virol. 2016;: pubmed
    Saffold virus (SAFV), a human cardiovirus, is occasionally detected in infants with neurological disorders, including meningitis and cerebellitis...
  19. Romanova L, Lidsky P, Kolesnikova M, Fominykh K, Gmyl A, Sheval E, et al. Antiapoptotic activity of the cardiovirus leader protein, a viral "security" protein. J Virol. 2009;83:7273-84 pubmed publisher
    ..Here, we show that the productive infection of HeLa cells with encephalomyocarditis virus (a cardiovirus) was not accompanied by full-fledged apoptosis (although the activation of caspases was detected late in ..
  20. Dorobantu C, Albulescu L, Harak C, Feng Q, van Kampen M, Strating J, et al. Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus. PLoS Pathog. 2015;11:e1005185 pubmed publisher
    ..In conclusion, we describe for the first time a cellular pathway involved in the biogenesis of cardiovirus ROs...
  21. Miyamoto M, Komuro A. PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2. Biochem Biophys Res Commun. 2017;494:227-233 pubmed publisher
    ..LGP2) and melanoma differentiation-associated gene 5 (MDA5) cooperatively detect viral RNA in the cytoplasm of Cardiovirus-infected cells and activate innate immune responses...
  22. Cardeti G, Mariano V, Eleni C, Aloisi M, Grifoni G, Sittinieri S, et al. Encephalomyocarditis virus infection in Macaca sylvanus and Hystrix cristata from an Italian rescue centre for wild and exotic animals. Virol J. 2016;13:193 pubmed
    ..virus (EMCV) is a small, non enveloped, positive sense single-stranded RNA virus in the genus Cardiovirus, family Picornaviridae, with two known serotypes...
  23. Komuro A, Homma Y, Negoro T, Barber G, Horvath C. The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Biochem Biophys Res Commun. 2016;480:187-193 pubmed publisher
    ..siRNA knockdown experiments indicate that TRBP is important for Cardiovirus-triggered interferon responses, but TRBP is not involved in Sendai virus-triggered interferon response that is ..
  24. Donnelly M, Gani D, Flint M, Monaghan S, Ryan M. The cleavage activities of aphthovirus and cardiovirus 2A proteins. J Gen Virol. 1997;78 ( Pt 1):13-21 pubmed
    ..Whilst the aphthovirus 2A region is only 16 aa (possibly 18 aa) long, the cardiovirus 2A protein is some 150 aa...
  25. Kaminski A, Jackson R. The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute. RNA. 1998;4:626-38 pubmed
  26. Zoll J, Galama J, Melchers W. Molecular identification of cardioviruses by enzymatic amplification. Mol Cell Probes. 1993;7:447-52 pubmed
    b>Cardiovirus specific sequences located in the 5' NTR are used to amplify viral RNA by PCR...
  27. Wutz G, Auer H, Nowotny N, Grosse B, Skern T, Kuechler E. Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses. J Gen Virol. 1996;77 ( Pt 8):1719-30 pubmed publisher
    ..These results place ERV-1 alongside FMDV in the aphthovirus genus of the picornavirus family and indicate that this virus may serve as a model system for examining the biology of FMDV...
  28. Nielsen A, Gyhrs M, Holmes E, Cui J. Co-circulation and persistence of genetically distinct saffold viruses, Denmark. Emerg Infect Dis. 2012;18:1694-6 pubmed publisher
  29. Ciomperlik J, Basta H, Palmenberg A. Cardiovirus Leader proteins bind exportins: Implications for virus replication and nucleocytoplasmic trafficking inhibition. Virology. 2016;487:19-26 pubmed publisher
    b>Cardiovirus Leader proteins (LX) inhibit cellular nucleocytoplasmic trafficking by directing host kinases to phosphorylate Phe/Gly-containing nuclear pore proteins (Nups)...
  30. de Bruyn P, Bastos A, Eadie C, Tosh C, Bester M. Mass mortality of adult male subantarctic fur seals: are alien mice the culprits?. PLoS ONE. 2008;3:e3757 pubmed publisher
    ..Although pathogens with gender-biased transmission and pathologies are unusual, rodents are known sources of male-biased infectious agents and the invasive Mus musculus house mouse, occurs in seal rookeries...
  31. Dmitrieva T, Alexeevski A, Shatskaya G, Tolskaya E, Gmyl A, Khitrina E, et al. Significance of the C-terminal amino acid residue in mengovirus RNA-dependent RNA polymerase. Virology. 2007;365:79-91 pubmed
    ..In particular, a comparative alignment indicates that the C-terminal sequences of cardiovirus RdRP (known also as 3D(pol)), are 1-amino-acid residue (arginine or tryptophan) longer than that of the ..
  32. Khamrin P, Thongprachum A, Kikuta H, Yamamoto A, Nishimura S, Sugita K, et al. Three clusters of Saffold viruses circulating in children with diarrhea in Japan. Infect Genet Evol. 2013;13:339-43 pubmed publisher
    Saffold virus (SAFV) is a newly discovered human virus in the genus Cardiovirus, family Picornaviridae. The virus was first described from fecal specimens of a child with fever of unknown origin in 2007...
  33. Svraka S, Rosario K, Duizer E, van der Avoort H, Breitbart M, Koopmans M. Metagenomic sequencing for virus identification in a public-health setting. J Gen Virol. 2010;91:2846-56 pubmed publisher
  34. Drexler J, Baumgarte S, Eschbach Bludau M, Simon A, Kemen C, Bode U, et al. Human cardioviruses, meningitis, and sudden infant death syndrome in children. Emerg Infect Dis. 2011;17:2313-5 pubmed publisher
    ..We screened 6,854 cerebrospinal fluid and 10 myocardium specimens from children and adults. A genotype 2 cardiovirus was detected from a child who died of sudden infant death syndrome, and 2 untypeable cardioviruses were ..
  35. Zhou Q, Zhang B, Xie Z, Gao H, Guo M, Zhang F, et al. [The research of saffold virus in children with lower respiratory tract infection in Changsha]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011;25:8-10 pubmed
    ..There existed SAFV infection in hospitalized children with lower respiratory infection in Changsha area; SAFV maybe related to disease onset with lower respiratory tract infection of children. ..
  36. Ercolini A, Miller S. Mechanisms of immunopathology in murine models of central nervous system demyelinating disease. J Immunol. 2006;176:3293-8 pubmed
    ..This review will discuss the immunopathologic mechanisms involved in these demyelinating disease models. ..
  37. Palmenberg A, Osorio J. Cardioviral poly(C) tracts and viral pathogenesis. Arch Virol Suppl. 1994;9:67-77 pubmed
    Mengovirus is a prototypical member of the cardiovirus genus of the family Picornaviridae. The positive-strand RNA genome is 7761 bases in length and encodes a polyprotein of 2293 amino acids...
  38. Ziegler E, Borman A, Deliat F, Liebig H, Jugovic D, Kean K, et al. Picornavirus 2A proteinase-mediated stimulation of internal initiation of translation is dependent on enzymatic activity and the cleavage products of cellular proteins. Virology. 1995;213:549-57 pubmed
    ..from rhino- and enteroviruses were interchangeable; however, stimulation of translation initiation on a cardiovirus IRES by these proteinases was minimal...
  39. Tan S, Chua K, Xu Y, Prabakaran M. The Pathogenesis of Saffold Virus in AG129 Mice and the Effects of Its Truncated L Protein in the Central Nervous System. Viruses. 2016;8: pubmed publisher
    Saffold Virus (SAFV) is a human cardiovirus that has been suggested to cause severe infection of the central nervous system (CNS)...
  40. Dessau R, Nielsen L, Frederiksen J. Absence of entero- and cardioviral RNA in multiple sclerosis brain tissue. Acta Neurol Scand. 1997;95:284-6 pubmed
    ..These results do not support the theory of a persisting entero- or cardioviral infection as the cause of Ms as we found no evidence of the presence of entero- or cardioviral genomes in the brains from MS patients. ..
  41. Ren L, Xiao Y, Li J, Chen L, Zhang J, Vernet G, et al. Multiple genomic recombination events in the evolution of saffold cardiovirus. PLoS ONE. 2013;8:e74947 pubmed publisher
    Saffold cardiovirus (SAFV) is a new human cardiovirus with 11 identified genotypes. Little is known about the natural history and pathogenicity of SAFVs...
  42. Mueller S, Wimmer E. Expression of foreign proteins by poliovirus polyprotein fusion: analysis of genetic stability reveals rapid deletions and formation of cardioviruslike open reading frames. J Virol. 1998;72:20-31 pubmed
    ..On the basis of our results, which are at variance with published data, the utility of poliovirus vectors to express proteins > 10 kDa in size through fusion with the polyprotein needs to be reevaluated. ..
  43. Itagaki T, Abiko C, Aoki Y, Ikeda T, Mizuta K, Noda M, et al. Saffold cardiovirus infection in children associated with respiratory disease and its similarity to coxsackievirus infection. Pediatr Infect Dis J. 2011;30:680-3 pubmed publisher
    Saffold virus (SAFV) is a newly discovered virus belonging to the genus Cardiovirus of the family Picornaviridae...
  44. Tracy S, Chapman N, Drescher K, Kono K, Tapprich W. Evolution of virulence in picornaviruses. Curr Top Microbiol Immunol. 2006;299:193-209 pubmed
    ..Ultimately, the ability of a picornavirus to induce disease depends upon viral genetics and how they are modulated by the host environment. ..
  45. Zoll J, Galama J, Van Kuppeveld F, Melchers W. Mengovirus leader is involved in the inhibition of host cell protein synthesis. J Virol. 1996;70:4948-52 pubmed
    The presence of a leader peptide in picornaviruses is restricted to the Cardiovirus and Aphthovirus genera. However, the leader peptides of these two genera are structurally and functionally unrelated...
  46. Himeda T, Hosomi T, Okuwa T, Muraki Y, Ohara Y. Saffold virus type 3 (SAFV-3) persists in HeLa cells. PLoS ONE. 2013;8:e53194 pubmed publisher
    Saffold virus (SAFV) was identified as a human cardiovirus in 2007. Although several epidemiological studies have been reported, they have failed to provide a clear picture of the relationship between SAFV and human diseases...
  47. Niklasson B, Kinnunen L, Hornfeldt B, Horling J, Benemar C, Hedlund K, et al. A new picornavirus isolated from bank voles (Clethrionomys glareolus). Virology. 1999;255:86-93 pubmed
    ..A partial 5' noncoding region sequence of Ljungan virus showed the highest degree of relatedness to cardioviruses. Two additional isolates were serologically and molecularly related to the prototype. ..
  48. Venkataraman S, Reddy S, Loo J, Idamakanti N, Hallenbeck P, Reddy V. Crystallization and preliminary X-ray diffraction studies of Seneca Valley virus-001, a new member of the Picornaviridae family. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:293-6 pubmed publisher
    ..nonsegmented (+)ssRNA genome of SVV-001 shares closest sequence similarity to the genomes of the members of the Cardiovirus genus...
  49. Lidsky P, Romanova L, Kolesnikova M, Bardina M, Khitrina E, Hato S, et al. Interactions between viral and prokaryotic pathogens in a mixed infection with cardiovirus and mycoplasma. J Virol. 2009;83:9940-51 pubmed publisher
    ..fmk strongly suppressed cardiovirus polyprotein processing, illustrating an additional pitfall in investigations of viral effects on the apoptotic ..