transmissible gastroenteritis virus

Summary

Summary: A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.

Top Publications

  1. Yin J, Ren X, Tian Z, Li Y. Assembly of pseudorabies virus genome-based transfer vehicle carrying major antigen sites of S gene of transmissible gastroenteritis virus: potential perspective for developing live vector vaccines. Biologicals. 2007;35:55-61 pubmed
    ..pseudorabies (PR) and transmissible gastroenteritis (TGE) caused by pseudorabies virus (PRV) and transmissible gastroenteritis virus (TGEV) respectively often result in serious economic loss in animal husbandry worldwide...
  2. Anand K, Ziebuhr J, Wadhwani P, Mesters J, Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science. 2003;300:1763-7 pubmed
    ..for human coronavirus (strain 229E) Mpro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (TGEV)] Mpro, and we constructed a homology model for SARS coronavirus (SARS-CoV) Mpro...
  3. Delmas B, Gelfi J, Sjostrom H, Noren O, Laude H. Further characterization of aminopeptidase-N as a receptor for coronaviruses. Adv Exp Med Biol. 1993;342:293-8 pubmed
    We recently reported that porcine aminopeptidase-N (pAPN) acts as a receptor for transmissible gastroenteritis virus (TGEV)...
  4. Ren X, Li G, Liu B. Binding characterization of determinants in porcine aminopeptidase N, the cellular receptor for transmissible gastroenteritis virus. J Biotechnol. 2010;150:202-6 pubmed publisher
    ..The binding ability of the proteins to transmissible gastroenteritis virus (TGEV), a porcine coronavirus, was analyzed by ELISA...
  5. Reguera J, Ordoño D, Santiago C, Enjuanes L, Casasnovas J. Antigenic modules in the N-terminal S1 region of the transmissible gastroenteritis virus spike protein. J Gen Virol. 2011;92:1117-26 pubmed publisher
    The N-terminal S1 region of the transmissible gastroenteritis virus (TGEV) spike (S) glycoprotein contains four antigenic sites (C, B, D and A, from the N- to the C-terminal end) and is engaged in host-cell receptor recognition...
  6. Yang C, Yang Y, Liang P, Chen C, Chen W, Chang H, et al. Novel small-molecule inhibitors of transmissible gastroenteritis virus. Antimicrob Agents Chemother. 2007;51:3924-31 pubmed
    We used swine testicle (ST) cells infected with transmissible gastroenteritis virus (TGEV) and an indirect immunofluorescent assay with antibodies against TGEV spike and nucleocapsid proteins to screen small-molecule compounds that ..
  7. Schwegmann Wessels C, Herrler G. Transmissible gastroenteritis virus infection: a vanishing specter. Dtsch Tierarztl Wochenschr. 2006;113:157-9 pubmed
    ..This virus is related to transmissible gastroenteritis virus (TGEV); however, it is not enteropathogenic but causes only minor respiratory symptoms...
  8. Putics A, Gorbalenya A, Ziebuhr J. Identification of protease and ADP-ribose 1''-monophosphatase activities associated with transmissible gastroenteritis virus non-structural protein 3. J Gen Virol. 2006;87:651-6 pubmed
    The replicase polyproteins, pp1a and pp1ab, of porcine Transmissible gastroenteritis virus (TGEV) have been predicted to be cleaved by viral proteases into 16 non-structural proteins (nsp)...
  9. Laude H, Van Reeth K, Pensaert M. Porcine respiratory coronavirus: molecular features and virus-host interactions. Vet Res. 1993;24:125-50 pubmed
    ..The authors' views concerning the impact of the emergence of PRCV on both coronavirus research and swine production are presented in the conclusion. ..

More Information

Publications95

  1. Lee B, Han Y, Kim S, Rahman M, Uyangaa E, Kim J, et al. Enhanced protection against infection with transmissible gastroenteritis virus in piglets by oral co-administration of live attenuated Salmonella enterica serovar Typhimurium expressing swine interferon-α and interleukin-18. Comp Immunol Microbiol Infect Dis. 2011;34:369-80 pubmed publisher
    ..of swine interferon-α (swIFN-α) and interleukin-18 (swIL-18) against infection with transmissible gastroenteritis virus (TGEV) in piglets using attenuated Salmonella enterica serovar Typhimurium as carrier of cytokine ..
  2. Zúñiga S, Sola I, Alonso S, Enjuanes L. Sequence motifs involved in the regulation of discontinuous coronavirus subgenomic RNA synthesis. J Virol. 2004;78:980-94 pubmed
    ..This template switch takes place after copying the CS sequence and was predicted in silico based on high base-pairing score between the nascent negative RNA strand and the TRS-L and minimum DeltaG. ..
  3. Alonso S, Izeta A, Sola I, Enjuanes L. Transcription regulatory sequences and mRNA expression levels in the coronavirus transmissible gastroenteritis virus. J Virol. 2002;76:1293-308 pubmed
    The transcription regulatory sequences (TRSs) of the coronavirus transmissible gastroenteritis virus (TGEV) have been characterized by using a helper virus-dependent expression system based on coronavirus-derived minigenomes to study the ..
  4. Schwegmann C, Zimmer G, Yoshino T, Enss M, Herrler G. Comparison of the sialic acid binding activity of transmissible gastroenteritis coronavirus and E. coli K99. Virus Res. 2001;75:69-73 pubmed
    ..From our results we conclude that E. coli K99 and TGEV interact with different sialoglycoconjugates to establish an intestinal infection. The implications for the enteropathogenicity of TGEV are discussed. ..
  5. Curtis K, Yount B, Sims A, Baric R. Reverse genetic analysis of the transcription regulatory sequence of the coronavirus transmissible gastroenteritis virus. J Virol. 2004;78:6061-6 pubmed
  6. Schwegmann Wessels C, Zimmer G, Laude H, Enjuanes L, Herrler G. Binding of transmissible gastroenteritis coronavirus to cell surface sialoglycoproteins. J Virol. 2002;76:6037-43 pubmed
    The surface glycoprotein S of transmissible gastroenteritis virus (TGEV) has two binding activities. (i) Binding to porcine aminopeptidase N (pAPN) is essential for the initiation of infection...
  7. Song D, Kang B, Oh J, Ha G, Yang J, Moon H, et al. Multiplex reverse transcription-PCR for rapid differential detection of porcine epidemic diarrhea virus, transmissible gastroenteritis virus, and porcine group A rotavirus. J Vet Diagn Invest. 2006;18:278-81 pubmed
    ..chain reaction (multiplex RT-PCR) that can detect porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine group A rotavirus (GAR) was developed...
  8. Yang H, Cao S, Huang X, Liu J, Tang Y, Wen X. Intragastric administration of attenuated Salmonella typhimurium harbouring transmissible gastroenteritis virus (TGEV) DNA vaccine induced specific antibody production. Vaccine. 2009;27:5035-40 pubmed publisher
    ..was selected as a transgenic vehicle for the development of live mucosal vaccines against transmissible gastroenteritis virus (TGEV). A 2...
  9. Benbacer L, Kut E, Besnardeau L, Laude H, Delmas B. Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus. J Virol. 1997;71:734-7 pubmed
    ..The human/canine APN chimera was also able to confer susceptibility to the porcine transmissible gastroenteritis virus (TGEV), whereas its human/porcine homolog failed to confer susceptibility to CCV and FIPV...
  10. Duarte M, Tobler K, Bridgen A, Rasschaert D, Ackermann M, Laude H. Sequence analysis of the porcine epidemic diarrhea virus genome between the nucleocapsid and spike protein genes reveals a polymorphic ORF. Virology. 1994;198:466-76 pubmed
    ..genetic subset, including two shorter polypeptides of human respiratory virus HCV 229E and one of transmissible gastroenteritis virus TGEV. This homology suggests that the two HCV ORFs may have originated from a single precursor...
  11. Callebaut P, Pensaert M, Hooyberghs J. A competitive inhibition ELISA for the differentiation of serum antibodies from pigs infected with transmissible gastroenteritis virus (TGEV) or with the TGEV-related porcine respiratory coronavirus. Vet Microbiol. 1989;20:9-19 pubmed
    ..inhibition ELISA was developed to detect non-neutralizing antibodies to the peplomer protein of transmissible gastroenteritis virus (TGEV) in porcine sera using a monoclonal antibody as an indicator...
  12. Ding L, Xu X, Huang Y, Li Z, Zhang K, Chen G, et al. Transmissible gastroenteritis virus infection induces apoptosis through FasL- and mitochondria-mediated pathways. Vet Microbiol. 2012;158:12-22 pubmed publisher
    b>Transmissible gastroenteritis virus (TGEV) has been reported to induce apoptosis in swine testis (ST) cells. However, the mechanisms underlying TGEV-induced apoptosis are still unclear...
  13. Chai W, Burwinkel M, Wang Z, Palissa C, Esch B, Twardziok S, et al. Antiviral effects of a probiotic Enterococcus faecium strain against transmissible gastroenteritis coronavirus. Arch Virol. 2013;158:799-807 pubmed publisher
    The enteropathogenic coronavirus transmissible gastroenteritis virus (TGEV) causes severe disease in young piglets. We have studied the protective effects of the probiotic Enterococcus faecium NCIMB 10415 (E...
  14. Ren X, Glende J, Yin J, Schwegmann Wessels C, Herrler G. Importance of cholesterol for infection of cells by transmissible gastroenteritis virus. Virus Res. 2008;137:220-4 pubmed publisher
    In this study, we addressed the question whether cholesterol is important for transmissible gastroenteritis virus (TGEV), a porcine coronavirus, in the initiation of an infection...
  15. Kim S, Kim I, Pyo H, Tark D, Song J, Hyun B. Multiplex real-time RT-PCR for the simultaneous detection and quantification of transmissible gastroenteritis virus and porcine epidemic diarrhea virus. J Virol Methods. 2007;146:172-7 pubmed
    b>Transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are major etiological agents of diarrhea and death in piglets...
  16. Delmas B, Gelfi J, L Haridon R, Vogel L, Sjostrom H, Noren O, et al. Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV. Nature. 1992;357:417-20 pubmed
    ..b>Transmissible gastroenteritis virus (TGEV), a major pathogen causing a fatal diarrhoea in newborn pig, replicates selectively in the ..
  17. Vemulapalli R, Gulani J, Santrich C. A real-time TaqMan RT-PCR assay with an internal amplification control for rapid detection of transmissible gastroenteritis virus in swine fecal samples. J Virol Methods. 2009;162:231-5 pubmed publisher
    A TaqMan probe-based real-time RT-PCR assay was developed for simultaneous detection of RNA of transmissible gastroenteritis virus (TGEV) in pig fecal samples and RNA of enhanced green fluorescent protein (EGFP) added exogenously as an ..
  18. Wang C, Chen J, Shi H, Qiu H, Xue F, Liu S, et al. Rapid differentiation of vaccine strain and Chinese field strains of transmissible gastroenteritis virus by restriction fragment length polymorphism of the N gene. Virus Genes. 2010;41:47-58 pubmed publisher
    A strain of transmissible gastroenteritis virus (TGEV), designated H16, was isolated in PK-15 cells and passaged serially to level 165...
  19. Wojdyla J, Manolaridis I, van Kasteren P, Kikkert M, Snijder E, Gorbalenya A, et al. Papain-like protease 1 from transmissible gastroenteritis virus: crystal structure and enzymatic activity toward viral and cellular substrates. J Virol. 2010;84:10063-73 pubmed publisher
    ..structural and biochemical characterization of a purified coronavirus PL1(pro) domain, that of transmissible gastroenteritis virus (TGEV)...
  20. Rodak L, Smid B, Nevorankova Z, Valíček L, Smitalova R. Use of monoclonal antibodies in blocking ELISA detection of transmissible gastroenteritis virus in faeces of piglets. J Vet Med B Infect Dis Vet Public Health. 2005;52:105-11 pubmed
    Monoclonal antibodies (mAb) to the transmissible gastroenteritis virus (TGEV) nucleoprotein (N) and membrane protein (M) were prepared and used for the comparative assessment of three blocking ELISA variants to detect TGEV...
  21. Schwegmann Wessels C, Bauer S, Winter C, Enjuanes L, Laude H, Herrler G. The sialic acid binding activity of the S protein facilitates infection by porcine transmissible gastroenteritis coronavirus. Virol J. 2011;8:435 pubmed publisher
    b>Transmissible gastroenteritis virus (TGEV) has a sialic acid binding activity that is believed to be important for enteropathogenicity, but that has so far appeared to be dispensable for infection of cultured cells...
  22. Anand K, Palm G, Mesters J, Siddell S, Ziebuhr J, Hilgenfeld R. Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain. EMBO J. 2002;21:3213-24 pubmed
    ..The study illustrates that RNA viruses have evolved unprecedented variations of the classical chymotrypsin fold. ..
  23. Have P. Infection with a new porcine respiratory coronavirus in Denmark: serologic differentiation from transmissible gastroenteritis virus using monoclonal antibodies. Adv Exp Med Biol. 1990;276:435-9 pubmed
    In 1984 neutralizing antibodies against transmissible gastroenteritis virus (TGEV) were detected in pig herds in a small geographical area in the southern part of Denmark...
  24. Paton D, Ibata G, Sands J, McGoldrick A. Detection of transmissible gastroenteritis virus by RT-PCR and differentiation from porcine respiratory coronavirus. J Virol Methods. 1997;66:303-9 pubmed
    ..method was developed that amplified genetic material from the 5' end of the S protein gene of both transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV), but discriminated between the two by the size of ..
  25. Curtis K, Yount B, Baric R. Heterologous gene expression from transmissible gastroenteritis virus replicon particles. J Virol. 2002;76:1422-34 pubmed
    We have recently isolated a transmissible gastroenteritis virus (TGEV) infectious construct designated TGEV 1000 (B. Yount, K. M. Curtis, and R. S. Baric, J. Virol. 74:10600-10611, 2000)...
  26. Liu C, Kokuho T, Kubota T, Watanabe S, Inumaru S, Yokomizo Y, et al. DNA mediated immunization with encoding the nucleoprotein gene of porcine transmissible gastroenteritis virus. Virus Res. 2001;80:75-82 pubmed
    The immune response to a naked plasmid DNA encoding the nucleoprotein (N protein) of porcine transmissible gastroenteritis virus (TGEV) was investigated in this study...
  27. Almazan F, Gonzalez J, Penzes Z, Izeta A, Calvo E, Plana Duran J, et al. Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome. Proc Natl Acad Sci U S A. 2000;97:5516-21 pubmed
    ..This demonstration opens up the possibility of employing this infectious cDNA as a vector for vaccine development in human, porcine, canine, and feline species susceptible to group 1 coronaviruses. ..
  28. Riffault S, Carrat C, Van Reeth K, Pensaert M, Charley B. Interferon-alpha-producing cells are localized in gut-associated lymphoid tissues in transmissible gastroenteritis virus (TGEV) infected piglets. Vet Res. 2001;32:71-9 pubmed
    b>Transmissible gastroenteritis virus (TGEV) infection of piglets results in a very rapid and massive release of IFN-alpha in serum and secretions...
  29. Bridgen A, Duarte M, Tobler K, Laude H, Ackermann M. Sequence determination of the nucleocapsid protein gene of the porcine epidemic diarrhoea virus confirms that this virus is a coronavirus related to human coronavirus 229E and porcine transmissible gastroenteritis virus. J Gen Virol. 1993;74 ( Pt 9):1795-804 pubmed publisher
    ..Several RNA motifs typical of coronaviruses were also observed. These results confirm the earlier provisional classification of PEDV as a coronavirus...
  30. Zhou J, Huang F, Hua X, Cui L, Zhang W, Shen Y, et al. Inhibition of porcine transmissible gastroenteritis virus (TGEV) replication in mini-pigs by shRNA. Virus Res. 2010;149:51-5 pubmed publisher
    b>Transmissible gastroenteritis virus (TGEV) is the causative agent of porcine transmissible gastroenteritis (TGE), characterized by high mortality and severely retarded growth in piglets that dramatically affects the porcine industry...
  31. Meng F, Yin J, Li X, Yang W, Li G, Ren X. Production and characterization of a monoclonal antibody against spike protein of transmissible gastroenteritis virus. Hybridoma (Larchmt). 2010;29:345-50 pubmed publisher
    b>Transmissible gastroenteritis virus (TGEV) is a member of coronaviruses. The viral spike (S) protein mediates the interaction between TGEV and its susceptible cells...
  32. Zhou J, Hua X, Cui L, Zhu J, Miao D, Zou Y, et al. Effective inhibition of porcine transmissible gastroenteritis virus replication in ST cells by shRNAs targeting RNA-dependent RNA polymerase gene. Antiviral Res. 2007;74:36-42 pubmed
    b>Transmissible gastroenteritis virus (TGEV) is identified as one of the most important pathogenic agents during swine enteric infection, leading to high mortality in neonatal pigs and severe annual economic loss in swine-producing areas...
  33. Yang C, Lee Y, Kang I, Barnard D, Jan J, Lin D, et al. Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus. Antiviral Res. 2010;88:160-8 pubmed publisher
    ..and phenanthroquinolizidines, as potent in vitro inhibitors of enteropathogenic coronavirus transmissible gastroenteritis virus (TGEV)...
  34. Huang C, Lokugamage K, Rozovics J, Narayanan K, Semler B, Makino S. Alphacoronavirus transmissible gastroenteritis virus nsp1 protein suppresses protein translation in mammalian cells and in cell-free HeLa cell extracts but not in rabbit reticulocyte lysate. J Virol. 2011;85:638-43 pubmed publisher
    The nsp1 protein of transmissible gastroenteritis virus (TGEV), an alphacoronavirus, efficiently suppressed protein synthesis in mammalian cells...
  35. Kim O, Choi C, Kim B, Chae C. Detection and differentiation of porcine epidemic diarrhoea virus and transmissible gastroenteritis virus in clinical samples by multiplex RT-PCR. Vet Rec. 2000;146:637-40 pubmed
    ..was developed for the simultaneous detection of porcine epidemic diarrhoea virus (PEDV) and transmissible gastroenteritis virus (TGEV) in preweaning pigs with diarrhoea...
  36. Ortego J, Sola I, Almazán F, Ceriani J, Riquelme C, Balasch M, et al. Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence. Virology. 2003;308:13-22 pubmed
    ..Interestingly, in vivo infections with rTGEV-delta7 showed an additional reduction in virus replication in the lung and gut, and in virulence, indicating that TGEV gene 7 influences virus pathogenesis. ..
  37. Schwegmann Wessels C, Zimmer G, Schröder B, Breves G, Herrler G. Binding of transmissible gastroenteritis coronavirus to brush border membrane sialoglycoproteins. J Virol. 2003;77:11846-8 pubmed
    ..A nonenteropathogenic mutant virus that lacked a sialic acid binding activity was unable to bind to MGP and to attach to goblet cells. Our results suggest a role of MGP in the enteropathogenicity of TGEV. ..
  38. Lamphear B, Jilka J, Kesl L, Welter M, Howard J, Streatfield S. A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine. Vaccine. 2004;22:2420-4 pubmed
    ..A subunit vaccine candidate directed against porcine transmissible gastroenteritis virus and expressed in corn seed has been developed for oral delivery to swine...
  39. Penzes Z, Gonzalez J, Calvo E, Izeta A, Smerdou C, Mendez A, et al. Complete genome sequence of transmissible gastroenteritis coronavirus PUR46-MAD clone and evolution of the purdue virus cluster. Virus Genes. 2001;23:105-18 pubmed
    ..Comparison of the TGEV polymerase sequence with that of other RNA viruses revealed high sequence homology with the A-E domains of the palm subdomain of nucleic acid polymerases. ..
  40. Sola I, Alonso S, Zúñiga S, Balasch M, Plana Durán J, Enjuanes L. Engineering the transmissible gastroenteritis virus genome as an expression vector inducing lactogenic immunity. J Virol. 2003;77:4357-69 pubmed
    The genome of the coronavirus transmissible gastroenteritis virus (TGEV) has been engineered as an expression vector with an infectious cDNA...
  41. Have P, Moving V, Svansson V, Uttenthal A, Bloch B. Coronavirus infection in mink (Mustela vison). Serological evidence of infection with a coronavirus related to transmissible gastroenteritis virus and porcine epidemic diarrhea virus. Vet Microbiol. 1992;31:1-10 pubmed
    Antibodies to a transmissible gastroenteritis virus (TGEV)-related coronavirus have been demonstrated in mink sera by indirect immunofluorescence, peroxidase-linked antibody assays and immunoblotting...
  42. Eleouet J, Chilmonczyk S, Besnardeau L, Laude H. Transmissible gastroenteritis coronavirus induces programmed cell death in infected cells through a caspase-dependent pathway. J Virol. 1998;72:4918-24 pubmed
    ..programmed cell death) is induced in different cell lines infected with a coronavirus, the porcine transmissible gastroenteritis virus (TGEV)...
  43. VanCott J, Brim T, Simkins R, Saif L. Isotype-specific antibody-secreting cells to transmissible gastroenteritis virus and porcine respiratory coronavirus in gut- and bronchus-associated lymphoid tissues of suckling pigs. J Immunol. 1993;150:3990-4000 pubmed
    ..lymphoid tissues of pigs exposed to three antigenically related coronaviruses: virulent transmissible gastroenteritis virus (TGEV), attenuated TGEV, and porcine respiratory coronavirus (PRCV)...
  44. Kim S, Song D, Park B. Differential detection of transmissible gastroenteritis virus and porcine epidemic diarrhea virus by duplex RT-PCR. J Vet Diagn Invest. 2001;13:516-20 pubmed
    ..This duplex RT-PCR may be a useful diagnostic method for the rapid, specific, and sensitive differential detection of TGE and PED viruses using clinical samples. ..
  45. Bestagno M, Sola I, Dallegno E, Sabella P, Poggianella M, Plana Durán J, et al. Recombinant dimeric small immunoproteins neutralize transmissible gastroenteritis virus infectivity efficiently in vitro and confer passive immunity in vivo. J Gen Virol. 2007;88:187-95 pubmed
    ..to provide protection against enteric infections when supplied orally, SIPs were generated against Transmissible gastroenteritis virus (TGEV), a highly pathogenic porcine virus...
  46. Zhang X, Hasoksuz M, Spiro D, Halpin R, Wang S, Stollar S, et al. Complete genomic sequences, a key residue in the spike protein and deletions in nonstructural protein 3b of US strains of the virulent and attenuated coronaviruses, transmissible gastroenteritis virus and porcine respiratory coronavirus. Virology. 2007;358:424-35 pubmed
    b>Transmissible gastroenteritis virus (TGEV) isolates that have been adapted to passage in cell culture maintain their infectivity in vitro but may lose their pathogenicity in vivo...
  47. Eleouet J, Slee E, Saurini F, Castagné N, Poncet D, Garrido C, et al. The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis. J Virol. 2000;74:3975-83 pubmed
    ..These data demonstrate that viral proteins can be targeted for destruction by the host cell death machinery. ..
  48. Calzada Nova G, Schnitzlein W, Husmann R, Zuckermann F. North American porcine reproductive and respiratory syndrome viruses inhibit type I interferon production by plasmacytoid dendritic cells. J Virol. 2011;85:2703-13 pubmed publisher
    ..interference since the typical IFN-α response by either purified or nonsorted porcine pDC to transmissible gastroenteritis virus (TGEV) or the Toll-like receptor 9 agonist, oligodeoxynucleotide (ODN) D19, was markedly reduced in ..
  49. Yin J, Ren X, Li Y. Molecular cloning and phylogenetic analysis of ORF7 region of chinese isolate TH-98 from transmissible gastroenteritis virus. Virus Genes. 2005;30:395-401 pubmed
    Genomic RNA was extracted from a Chinese isolate of porcine transmissible gastroenteritis virus (TGEV) designated TH-98...
  50. Calvo E, Escors D, Lopez J, Gonzalez J, Alvarez A, Arza E, et al. Phosphorylation and subcellular localization of transmissible gastroenteritis virus nucleocapsid protein in infected cells. J Gen Virol. 2005;86:2255-67 pubmed
    The nucleocapsid (N) protein is the only phosphorylated structural protein of the coronavirus Transmissible gastroenteritis virus (TGEV)...
  51. Gonzalez J, Penzes Z, Almazán F, Calvo E, Enjuanes L. Stabilization of a full-length infectious cDNA clone of transmissible gastroenteritis coronavirus by insertion of an intron. J Virol. 2002;76:4655-61 pubmed
    ..The insertion in two different positions allowed stable plasmid amplification for at least 200 generations. Infectious TGEV was efficiently recovered from cells transfected with the modified cDNAs. ..
  52. Alonso S, Sola I, Teifke J, Reimann I, Izeta A, Balasch M, et al. In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes. J Gen Virol. 2002;83:567-79 pubmed
    ..The large cloning capacity and the tissue specificity of the TGEV-derived minigenomes suggest that these virus vectors are very promising for vaccine development. ..
  53. Pensaert M, Cox E, Van Deun K, Callebaut P. A sero-epizootiological study of porcine respiratory coronavirus in Belgian swine. Vet Q. 1993;15:16-20 pubmed
    A porcine respiratory coronavirus (PRCV), antigenically closely related to transmissible gastroenteritis virus (TGEV), appeared in the European swine population in 1984...
  54. Hegyi A, Kolb A. Characterization of determinants involved in the feline infectious peritonitis virus receptor function of feline aminopeptidase N. J Gen Virol. 1998;79 ( Pt 6):1387-91 pubmed
    ..N (fAPN) is a major cell surface receptor for feline infectious peritonitis virus (FIPV), transmissible gastroenteritis virus (TGEV), human coronavirus 229E (HCV 229E) and canine coronavirus (CCV)...
  55. Zhang J. Porcine deltacoronavirus: Overview of infection dynamics, diagnostic methods, prevalence and genetic evolution. Virus Res. 2016;226:71-84 pubmed publisher
    ..in inoculated pigs and need to be differentially diagnosed from porcine epidemic diarrhea virus and transmissible gastroenteritis virus in the field...
  56. Song Z, Dai X, Ye C, Li Y, Wang L, Hu Y. Morphogenesis and proliferative rule of porcine transmissible gastroenteritis virus in porcine intestinal epithelial cells. J Virol Methods. 2016;238:6-12 pubmed publisher
    ..a better understanding of the replication, proliferation and infection characteristics of porcine transmissible gastroenteritis virus (TGEV) in porcine intestinal epithelial cells (IECs), this study established a cell model of IECs ..
  57. Dufour D, Mateos Gomez P, Enjuanes L, Gallego J, Sola I. Structure and functional relevance of a transcription-regulating sequence involved in coronavirus discontinuous RNA synthesis. J Virol. 2011;85:4963-73 pubmed publisher
    ..TRS-L mutations altering the structure and the stability of the TRS-L hairpin affected replication and transcription, indicating the requirement of a functional RNA hairpin structure in these processes. ..
  58. Shockley L, Kapke P, Lapps W, Brian D, Potgieter L, Woods R. Diagnosis of porcine and bovine enteric coronavirus infections using cloned cDNA probes. J Clin Microbiol. 1987;25:1591-6 pubmed
    ..Dot blot hybridization for transmissible gastroenteritis coronavirus diagnosis was compared with the routine procedures of virus isolation and electron microscopy as a diagnostic test. ..
  59. Maragkoudakis P, Chingwaru W, Gradisnik L, Tsakalidou E, Cencic A. Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection. Int J Food Microbiol. 2010;141 Suppl 1:S91-7 pubmed publisher
    ..co-incubated with cell line monolayers, which were subsequently challenged with rotavirus (RV) and transmissible gastroenteritis virus (TGEV)...
  60. Zou H, Zarlenga D, Sestak K, Suo S, Ren X. Transmissible gastroenteritis virus: identification of M protein-binding peptide ligands with antiviral and diagnostic potential. Antiviral Res. 2013;99:383-90 pubmed publisher
    ..In this study, the M protein of transmissible gastroenteritis virus (TGEV) was used to biopan a 12-mer phage display random peptide library...
  61. Meng F, Suo S, Zarlenga D, Cong Y, Ma X, Zhao Q, et al. A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry. Virology. 2014;456-457:20-7 pubmed publisher
    ..H, S and F that recognize porcine aminopeptidase N (pAPN), the cellular receptor of porcine transmissible gastroenteritis virus (TGEV) were able to inhibit cell infection by TGEV...
  62. Farnsworth J, Goyal S, Kim S, Kuehn T, Raynor P, Ramakrishnan M, et al. Development of a method for bacteria and virus recovery from heating, ventilation, and air conditioning (HVAC) filters. J Environ Monit. 2006;8:1006-13 pubmed
    ..niger was chosen as a surrogate for Bacillus anthracis. Three animal viruses; transmissible gastroenteritis virus (TGEV), avian pneumovirus (APV), and fowlpox virus were chosen as surrogates for three human ..
  63. Ribes J, Ortego J, Ceriani J, Montava R, Enjuanes L, Buesa J. Transmissible gastroenteritis virus (TGEV)-based vectors with engineered murine tropism express the rotavirus VP7 protein and immunize mice against rotavirus. Virology. 2011;410:107-18 pubmed publisher
    A coronavirus vector based on the genome of the porcine transmissible gastroenteritis virus (TGEV) expressing the rotavirus VP7 protein was constructed to immunize and protect against rotavirus infections in a murine model...
  64. Brown I, Paton D. Serological studies of transmissible gastroenteritis in Great Britain, using a competitive ELISA. Vet Rec. 1991;128:500-3 pubmed
    A competitive ELISA which differentiates between transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) was used to detect non-neutralising antibodies to the peplomer protein of TGEV in porcine sera...
  65. Okda F, Liu X, Singrey A, Clement T, Nelson J, Christopher Hennings J, et al. Development of an indirect ELISA, blocking ELISA, fluorescent microsphere immunoassay and fluorescent focus neutralization assay for serologic evaluation of exposure to North American strains of Porcine Epidemic Diarrhea Virus. BMC Vet Res. 2015;11:180 pubmed publisher
    ..No cross-reactivity with the closely related coronaviruses, transmissible gastroenteritis virus (TGEV) or porcine respiratory coronavirus (PRCV) was noted with these assays...
  66. Wei Z, Burwinkel M, Palissa C, Ephraim E, Schmidt M. Antiviral activity of zinc salts against transmissible gastroenteritis virus in vitro. Vet Microbiol. 2012;160:468-72 pubmed publisher
    ..zinc chloride (ZnCl(2)) and zinc sulfate (ZnSO(4)), on infection of swine testicle (ST) cells with transmissible gastroenteritis virus (TGEV) and compared it to the effects of a control salt, magnesium sulfate (MgSO(4))...
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