infectious hematopoietic necrosis virus

Summary

Summary: The type species of NOVIRHABDOVIRUS, in the family RHABDOVIRIDAE. It is a major pathogen of TROUT and SALMON.

Top Publications

  1. Alonso M, Rodríguez Saint Jean S, Perez Prieto S. Virulence of infectious hematopoietic necrosis virus and Infectious pancreatic necrosis virus coinfection in rainbow trout ( Oncorhynchus mykiss) and nucleotide sequence analysis of the IHNV glycoprotein gene. Arch Virol. 2003;148:1507-21 pubmed
    The outcomes of a coinfection of rainbow trout ( Oncorhynchus mykiss) with Infectious hematopoietic necrosis virus (IHNV) strain S46 and Infectious pancreatic necrosis virus (IPNV) strain S46 was determined after waterborne infection...
  2. Quillet E, Dorson M, Le Guillou S, Benmansour A, Boudinot P. Wide range of susceptibility to rhabdoviruses in homozygous clones of rainbow trout. Fish Shellfish Immunol. 2007;22:510-9 pubmed
    ..Although VHSV-resistant clones were not fully resistant to IHNV, the susceptibility to IHNV and VHSV tended to be correlated, suggesting that non-specific mechanisms common to both viruses were involved...
  3. Purcell M, Nichols K, Winton J, Kurath G, Thorgaard G, Wheeler P, et al. Comprehensive gene expression profiling following DNA vaccination of rainbow trout against infectious hematopoietic necrosis virus. Mol Immunol. 2006;43:2089-106 pubmed
    The DNA vaccine based on the glycoprotein gene of Infectious hematopoietic necrosis virus induces a non-specific anti-viral immune response and long-term specific immunity against IHNV...
  4. Brudeseth B, Castric J, Evensen O. Studies on pathogenesis following single and double infection with viral hemorrhagic septicemia virus and infectious hematopoietic necrosis virus in rainbow trout (Oncorhynchus mykiss). Vet Pathol. 2002;39:180-9 pubmed
  5. Kim S, Kim S, Oh M, Jung S, Kang S. In vitro antiviral activity of red alga, Polysiphonia morrowii extract and its bromophenols against fish pathogenic infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus. J Microbiol. 2011;49:102-6 pubmed publisher
    ..alga Polysiphonia morrowii has significant antiviral activities against fish pathogenic viruses, infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV)...
  6. Ludwig M, Palha N, Torhy C, Briolat V, Colucci Guyon E, Bremont M, et al. Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae. PLoS Pathog. 2011;7:e1001269 pubmed publisher
    ..here the course of infection of zebrafish early larvae with a heat-adapted variant of the Infectious Hematopoietic Necrosis Virus (IHNV), a rhabdovirus that represents an important threat to the salmonid culture industry...
  7. Rodriguez M, Wiens G, Purcell M, Palti Y. Characterization of Toll-like receptor 3 gene in rainbow trout (Oncorhynchus mykiss). Immunogenetics. 2005;57:510-9 pubmed
    ..by quantitative real-time polymerase chain reaction (PCR) after poly inosinic:cytidylic (I:C) and infectious hematopoietic necrosis virus (IHNV) treatments...
  8. Kim W, Oh M, Nishizawa T, Park J, Kurath G, Yoshimizu M. Genotyping of Korean isolates of infectious hematopoietic necrosis virus (IHNV) based on the glycoprotein gene. Arch Virol. 2007;152:2119-24 pubmed
    Glycoprotein (G) gene nucleotide sequences of four Korean isolates of infectious hematopoietic necrosis virus (IHNV) were analyzed to evaluate their genetic relatedness to worldwide isolates...
  9. Rudakova S, Kurath G, Bochkova E. Occurrence and genetic typing of infectious hematopoietic necrosis virus in Kamchatka, Russia. Dis Aquat Organ. 2007;75:1-11 pubmed
    b>Infectious hematopoietic necrosis virus (IHNV) is a well known rhabdoviral pathogen of salmonid fish in North America that has become established in Asia and Europe...

More Information

Publications90

  1. Overturf K, Lapatra S. Quantitative expression (Walbaum) of immunological factors in rainbow trout, Oncorhynchus mykiss (Walbaum), after infection with either Flavobacterium psychrophilum, Aeromonas salmonicida, or infectious haematopoietic necrosis virus. J Fish Dis. 2006;29:215-24 pubmed
    ..Infection with A. salmonicida and F. psychrophilum showed elevated, but variable expression levels for several of the genes tested. ..
  2. Alonso M, Kim C, Johnson M, Pressley M, Leong J. The NV gene of snakehead rhabdovirus (SHRV) is not required for pathogenesis, and a heterologous glycoprotein can be incorporated into the SHRV envelope. J Virol. 2004;78:5875-82 pubmed
    ..Finally, we demonstrated that the SHRV glycoprotein can be replaced by the glycoprotein of infectious hematopoietic necrosis virus (IHNV) or by a hybrid protein composed of SHRV and IHNV sequences.
  3. Enzmann P, Kurath G, Fichtner D, Bergmann S. Infectious hematopoietic necrosis virus: monophyletic origin of European isolates from North American genogroup M. Dis Aquat Organ. 2005;66:187-95 pubmed
    b>Infectious hematopoietic necrosis virus (IHNV) was first detected in Europe in 1987 in France and Italy, and later, in 1992, in Germany. The source of the virus and the route of introduction are unknown...
  4. Purcell M, LaPatra S, Woodson J, Kurath G, Winton J. Early viral replication and induced or constitutive immunity in rainbow trout families with differential resistance to Infectious hematopoietic necrosis virus (IHNV). Fish Shellfish Immunol. 2010;28:98-105 pubmed publisher
    ..of innate resistance in rainbow trout full-sibling families that differ in susceptibility to Infectious hematopoietic necrosis virus (IHNV)...
  5. Clifford M, Eder K, Werner I, Hedrick R. Synergistic effects of esfenvalerate and infectious hematopoietic necrosis virus on juvenile chinook salmon mortality. Environ Toxicol Chem. 2005;24:1766-72 pubmed
    ..exposed to sublethal levels of esfenvalerate or chlorpyrifos either alone or concurrently with infectious hematopoietic necrosis virus (IHNV). Three trials were performed with fish exposed to concentrations of IHNV between 0...
  6. Thoulouze M, Bouguyon E, Carpentier C, Bremont M. Essential role of the NV protein of Novirhabdovirus for pathogenicity in rainbow trout. J Virol. 2004;78:4098-107 pubmed
    Novirhabdovirus, infectious hematopoietic necrosis virus (IHNV), and viral hemorrhagic septicemia virus (VHSV) are fish rhabdoviruses that, in comparison to the other rhabdoviruses, contain an additional gene coding for a small nonvirion ..
  7. Saint Jean S, Pérez Prieto S. Interferon mediated antiviral activity against salmonid fish viruses in BF-2 and other cell lines. Vet Immunol Immunopathol. 2006;110:1-10 pubmed
    ..poly I:C plus transfection agents against the infectious pancreatic necrosis virus (IPNV) and the infectious hematopoietic necrosis virus (IHNV) in BF-2 cells, with that induced in RTG-2, CHSE-214, or SAF cells...
  8. Kurath G, Garver K, Troyer R, Emmenegger E, Einer Jensen K, Anderson E. Phylogeography of infectious haematopoietic necrosis virus in North America. J Gen Virol. 2003;84:803-14 pubmed
    b>Infectious hematopoietic necrosis virus (IHNV) is a rhabdoviral pathogen that infects wild and cultured salmonid fish throughout the Pacific Northwest of North America...
  9. Romero A, Figueras A, Tafalla C, Thoulouze M, Bremont M, Novoa B. Histological, serological and virulence studies on rainbow trout experimentally infected with recombinant infectious hematopoietic necrosis viruses. Dis Aquat Organ. 2005;68:17-28 pubmed
    ..Finally, antibody production was highest in fish infected with the rIHNVmut-Gmut even though this virus was the least virulent. ..
  10. Wargo A, Garver K, Kurath G. Virulence correlates with fitness in vivo for two M group genotypes of Infectious hematopoietic necrosis virus (IHNV). Virology. 2010;404:51-8 pubmed publisher
    ..We examined the relationship between virulence and fitness in Infectious hematopoietic necrosis virus (IHNV), in vivo, in intact living rainbow trout...
  11. Wang L, Wang L, Zhang H, Zhang J, Chen W, Ruan X, et al. In vitro effects of recombinant zebrafish IFN on spring viremia of carp virus and infectious hematopoietic necrosis virus. J Interferon Cytokine Res. 2006;26:256-9 pubmed
    ..In addition, the effects of recombinant DreIFN (rDreIFN) on spring viremia of carp virus (SVCV), infectious hematopoietic necrosis virus (IHNV), and vesicular stomatitis virus (VSV) were surveyed in fish and chicken cells...
  12. Ooi E, Verjan N, Haraguchi I, Oshima T, Kondo H, Hirono I, et al. Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus. Dev Comp Immunol. 2008;32:1211-20 pubmed publisher
    ..greater protection than a phosphate buffered saline (PBS) injection against a lethal challenge of infectious hematopoietic necrosis virus (IHNV), with a relative percent survival of 39%...
  13. Kurath G, Garver K, Corbeil S, Elliott D, Anderson E, LaPatra S. Protective immunity and lack of histopathological damage two years after DNA vaccination against infectious hematopoietic necrosis virus in trout. Vaccine. 2006;24:345-54 pubmed
    The DNA vaccine pIHNw-G encodes the glycoprotein of the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV). Vaccine performance in rainbow trout was measured 3, 6, 13, 24, and 25 months after vaccination...
  14. Biacchesi S, Béarzotti M, Bouguyon E, Bremont M. Heterologous exchanges of the glycoprotein and the matrix protein in a Novirhabdovirus. J Virol. 2002;76:2881-9 pubmed
    b>Infectious hematopoietic necrosis virus (IHNV) and viral hemorrhagic septicemia virus (VHSV) are two salmonid rhabdoviruses replicating at low temperatures (14 to 20 degrees C)...
  15. MacKenzie S, Balasch J, Novoa B, Ribas L, Roher N, Krasnov A, et al. Comparative analysis of the acute response of the trout, O. mykiss, head kidney to in vivo challenge with virulent and attenuated infectious hematopoietic necrosis virus and LPS-induced inflammation. BMC Genomics. 2008;9:141 pubmed publisher
    ..mykiss, head kidney to bacterial lipopolysaccharide (LPS) or active and attenuated infectious hematopoietic necrosis virus (IHNV and attINHV respectively) intraperitoneal challenge, 24 and 72 hours post-injection, was ..
  16. Verjan N, Ooi E, Nochi T, Kondo H, Hirono I, Aoki T, et al. A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2008;25:170-80 pubmed publisher
    ..We found that a soluble recombinant infectious hematopoietic necrosis virus G-protein (rIHNV-G) stimulated an early innate immune response mediated by proinflammatory ..
  17. Nishizawa T, Kinoshita S, Kim W, Higashi S, Yoshimizu M. Nucleotide diversity of Japanese isolates of infectious hematopoietic necrosis virus (IHNV) based on the glycoprotein gene. Dis Aquat Organ. 2006;71:267-72 pubmed
    b>Infectious hematopoietic necrosis virus (IHNV), a member of the genus Novirhabdovirus, causes a highly lethal disease of salmonid fish...
  18. Peñaranda M, Purcell M, Kurath G. Differential virulence mechanisms of infectious hematopoietic necrosis virus in rainbow trout (Oncorhynchus mykiss) include host entry and virus replication kinetics. J Gen Virol. 2009;90:2172-82 pubmed publisher
    Host specificity is a phenomenon exhibited by all viruses. For the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV), differential specificity of virus strains from the U and M genogroups has been established both in the ..
  19. Purcell M, Kurath G, Garver K, Herwig R, Winton J. Quantitative expression profiling of immune response genes in rainbow trout following infectious haematopoietic necrosis virus (IHNV) infection or DNA vaccination. Fish Shellfish Immunol. 2004;17:447-62 pubmed
    ..The gene expression profiles elicited by the live virus and the IHNV DNA vaccine differed in a number of aspects but this study confirms the clear role for a type I interferon-like response in early anti-viral defence. ..
  20. Purcell M, Marjara I, Batts W, Kurath G, Hansen J. Transcriptome analysis of rainbow trout infected with high and low virulence strains of infectious hematopoietic necrosis virus. Fish Shellfish Immunol. 2011;30:84-93 pubmed publisher
    There are three main genetic lineages or genogroups of Infectious hematopoietic necrosis virus (IHNV) in N. America. Strains representing the M genogroup are more virulent in rainbow trout relative to the U genogroup...
  21. Troyer R, Kurath G. Molecular epidemiology of infectious hematopoietic necrosis virus reveals complex virus traffic and evolution within southern Idaho aquaculture. Dis Aquat Organ. 2003;55:175-85 pubmed
    b>Infectious hematopoietic necrosis virus (IHNV) is a rhabdovirus which infects salmon and trout and may cause disease with up to 90% mortality...
  22. Alonso M, Chiou P, Leong J. Development of a suicidal DNA vaccine for infectious hematopoietic necrosis virus (IHNV). Fish Shellfish Immunol. 2011;30:815-23 pubmed publisher
    We developed a suicidal DNA vaccine (pIRF1A-G-pMT-M) for salmonid fish susceptible to Infectious Hematopoietic Necrosis Virus (IHNV)...
  23. Liu H, Liu Y, Liu S, Pang D, Xiao G. Clathrin-mediated endocytosis in living host cells visualized through quantum dot labeling of infectious hematopoietic necrosis virus. J Virol. 2011;85:6252-62 pubmed publisher
    b>Infectious hematopoietic necrosis virus (IHNV) is an important fish pathogen that infects both wild and cultured salmonids...
  24. Liu X, Collodi P. Novel form of fibronectin from zebrafish mediates infectious hematopoietic necrosis virus infection. J Virol. 2002;76:492-8 pubmed
    ..fibronectin (FN2) on the cell surface increased the cell's susceptibility to infection by infectious hematopoietic necrosis virus (IHNV)...
  25. Landis E, Purcell M, Thorgaard G, Wheeler P, Hansen J. Transcriptional profiling of MHC class I genes in rainbow trout infected with infectious hematopoietic necrosis virus. Mol Immunol. 2008;45:1646-57 pubmed publisher
    ..Our results support a non-classical designation for the majority of the class IB genes surveyed in this study based upon expression levels while also indicating that they may play an important role in anti-viral immunity in trout...
  26. Ammayappan A, LaPatra S, Vakharia V. A vaccinia-virus-free reverse genetics system for infectious hematopoietic necrosis virus. J Virol Methods. 2010;167:132-9 pubmed publisher
    ..An improved system for the recovery of infectious hematopoietic necrosis virus (IHNV) was developed which utilizes cellular RNA polymerase II machinery for transcription...
  27. Biacchesi S, Lamoureux A, Merour E, Bernard J, Bremont M. Limited interference at the early stage of infection between two recombinant novirhabdoviruses: viral hemorrhagic septicemia virus and infectious hematopoietic necrosis virus. J Virol. 2010;84:10038-50 pubmed publisher
    ..This deletion mutant was shown to be as debilitated as that previously described for infectious hematopoietic necrosis virus (IHNV), a distantly related novirhabdovirus (S. Biacchesi, M. I. Thoulouze, M. Bearzotti, Y. X...
  28. Kurath G, Garver K, LaPatra S, Purcell M. Resistance and protective immunity in Redfish Lake sockeye salmon exposed to M type infectious hematopoietic necrosis virus (IHNV). J Aquat Anim Health. 2010;22:129-39 pubmed publisher
    Differential virulence of infectious hematopoietic necrosis virus (IHNV) isolates from the U and M phylogenetic subgroups is clearly evident in the Redfish Lake (RFL) strain of sockeye salmon Oncorhynchus nerka...
  29. Hansen J, La Patra S. Induction of the rainbow trout MHC class I pathway during acute IHNV infection. Immunogenetics. 2002;54:654-61 pubmed
    ..During peak infection with infectious hematopoietic necrosis virus, induction of STAT-1, PSMB9A and ABCB2 mRNA was evident in all tissues within infected fish, as ..
  30. Bergmann S, Fichtner D, Skall H, Schlotfeldt H, Olesen N. Age- and weight-dependent susceptibility of rainbow trout Oncorhynchus mykiss to isolates of infectious haematopoietic necrosis virus (IHNV) of varying virulence. Dis Aquat Organ. 2003;55:205-10 pubmed
    ..An age/weight related susceptibility of rainbow trout was demonstrated under the defined conditions for all IHNV isolates tested. ..
  31. Booy A, Haddow J, Ohlund L, Hardie D, Olafson R. Application of isotope coded affinity tag (ICAT) analysis for the identification of differentially expressed proteins following infection of atlantic salmon (Salmo salar) with infectious hematopoietic necrosis virus (IHNV) or Renibacterium salmoninar. J Proteome Res. 2005;4:325-34 pubmed
    ..Examples of the latter are discussed here and include, a natural killer cell enhancement factor (NKEF), procathepsin L, superoxide-producing NADPH oxidase and interferon-induced viral resistance protein Mx (IFI-Mx). ..
  32. Purcell M, Hart S, Kurath G, Winton J. Strand-specific, real-time RT-PCR assays for quantification of genomic and positive-sense RNAs of the fish rhabdovirus, Infectious hematopoietic necrosis virus. J Virol Methods. 2006;132:18-24 pubmed
    The fish rhabdovirus, Infectious hematopoietic necrosis virus (IHNV), is an important pathogen of salmonids...
  33. Harmache A, LeBerre M, Droineau S, Giovannini M, Bremont M. Bioluminescence imaging of live infected salmonids reveals that the fin bases are the major portal of entry for Novirhabdovirus. J Virol. 2006;80:3655-9 pubmed
    ..We provide here evidence that the fin bases are the portal of entry into the fish. Confirmation was brought by the use of a nonpathogenic rIHNV, which was shown to persist in fins for 3 weeks postinfection...
  34. Saint Jean S, Pérez Prieto S. Effects of salmonid fish viruses on Mx gene expression and resistance to single or dual viral infections. Fish Shellfish Immunol. 2007;23:390-400 pubmed
    ..These results indicate that activation of the immune system could explain the interference and loss of IHNV in the IPNV-IHNV co-infections. ..
  35. St Hilaire S, Ribble C, Traxler G, Davies T, Kent M. Evidence for a carrier state of infectious hematopoietic necrosis virus in chinook salmon Oncorhynchus tshawytscha. Dis Aquat Organ. 2001;46:173-9 pubmed
    In British Columbia, Canada, infectious hematopoietic necrosis virus (IHNV) is prevalent in wild sockeye salmon Oncorhynchus nerka and has caused disease in seawater net-pen reared Atlantic salmon Salmo salar...
  36. Yu X, Wang J, Zhang W, Shi Z. Prevalence of three shrimp viruses in Zhejiang Province in 2008. Virol Sin. 2011;26:67-71 pubmed publisher
    ..This study provides comprehensive information of the prevalence of three shrimp viruses in Zhejiang and may be helpful for disease prevention control in this region. ..
  37. Zhao J, Xu L, Liu M, Cao Y, LaPatra S, Yin J, et al. An efficient and simple method to increase the level of displayed protein on the yeast cell surface. J Microbiol Methods. 2017;135:41-47 pubmed publisher
    ..We used the single chain variable fragment (scFv) of an antibody against the infectious hematopoietic necrosis virus isolate Sn1203 as a target display protein...
  38. Bergmann S, Ariel E, Skall H, Fichtner D, Schlotfeldt H, Olesen N. [Comparison of methods for detection of an infection with different isolates of infectious haematopoietic necrosis virus (IHNV)]. Berl Munch Tierarztl Wochenschr. 2002;115:385-9 pubmed
  39. Kim M, Kim K. Inhibition of viral hemorrhagic septicemia virus replication using a short hairpin RNA targeting the G gene. Arch Virol. 2011;156:457-64 pubmed publisher
    ..Furthermore, shRNA-VG594 expressed in EPC cells did not confer protection against infectious hematopoietic necrosis virus (IHNV), suggesting sequence-specific RNAi-dependent suppression of viral replication.
  40. Zhao J, Xu L, Liu M, Cao Y, LaPatra S, Yin J, et al. Preliminary study of an oral vaccine against infectious hematopoietic necrosis virus using improved yeast surface display technology. Mol Immunol. 2017;85:196-204 pubmed publisher
    b>Infectious hematopoietic necrosis virus (IHNV) is a common pathogen that causes severe disease in the salmonid aquaculture industry...
  41. Purcell M, Garver K, Conway C, Elliott D, Kurath G. Infectious haematopoietic necrosis virus genogroup-specific virulence mechanisms in sockeye salmon, Oncorhynchus nerka (Walbaum), from Redfish Lake, Idaho. J Fish Dis. 2009;32:619-31 pubmed publisher
    ..We hypothesize that high virulence is associated with early in vivo replication allowing the virus to achieve a threshold level, which the host innate immune system cannot control...
  42. Romero A, Figueras A, Thoulouze M, Bremont M, Novoa B. Recombinant infectious hematopoietic necrosis viruses induce protection for rainbow trout Oncorhynchus mykiss. Dis Aquat Organ. 2008;80:123-35 pubmed publisher
    b>Infectious hematopoietic necrosis virus (IHNV) and viral hemorrhagic septicaemia virus (VHSV) are rhabdoviruses that infect salmonids, producing serious economic losses. Two recombinant IHN viruses were generated by reverse genetics...
  43. Kelley G, Bendorf C, Yun S, Kurath G, Hedrick R. Genotypes and phylogeographical relationships of infectious hematopoietic necrosis virus in California, USA. Dis Aquat Organ. 2007;77:29-40 pubmed
    b>Infectious hematopoietic necrosis virus (IHNV) contains 3 major genogroups in North America with discreet geographic ranges designated as upper (U), middle (M), and lower (L)...
  44. Romero A, Dios S, Bremont M, Figueras A, Novoa B. Interaction of the attenuated recombinant rIHNV-Gvhsv GFP virus with macrophages from rainbow trout (Oncorhynchus mykiss). Vet Immunol Immunopathol. 2011;140:119-29 pubmed publisher
  45. Verrier E, Ehanno A, Biacchesi S, Le Guillou S, Dechamp N, Boudinot P, et al. Lack of correlation between the resistances to two rhabdovirus infections in rainbow trout. Fish Shellfish Immunol. 2013;35:9-17 pubmed publisher
    The Viral Hemorrhagic Septicemia Virus (VHSV) and the Infectious Hematopoietic Necrosis Virus (IHNV) are two rhabdoviruses responsible for serious outbreaks in salmonid farms...
  46. Liu Z, Teng Y, Liu H, Jiang Y, Xie X, Li H, et al. Simultaneous detection of three fish rhabdoviruses using multiplex real-time quantitative RT-PCR assay. J Virol Methods. 2008;149:103-9 pubmed publisher
    Spring viremia of carp virus (SVCV), infectious hematopoietic necrosis virus (IHNV) and viral hemorrhagic septicemia virus (VHSV) are three important fish rhabdoviruses, causing serious Office International des Epizooties (OIE) ..
  47. McKenney D, Kurath G, Wargo A. Characterization of infectious dose and lethal dose of two strains of infectious hematopoietic necrosis virus (IHNV). Virus Res. 2016;214:80-9 pubmed publisher
    ..In this study we have quantified the infectivity of two strains of infectious hematopoietic necrosis virus (IHNV) that are known to differ in fitness and virulence...
  48. Falco A, Chico V, Marroquí L, Perez L, Coll J, Estepa A. Expression and antiviral activity of a beta-defensin-like peptide identified in the rainbow trout (Oncorhynchus mykiss) EST sequences. Mol Immunol. 2008;45:757-65 pubmed
    ..To our knowledge, this is the first report showing biological activity of a beta-defensin-like peptide from any fish. ..
  49. Popova A, Oreshkova S, Zhchelkunov I, Rudakova S, Zhchelkunova T, Tikunova N, et al. [RT-PCR-based methods for identification and typing of infectious hemopoietic necrosis virus in salmons]. Vopr Virusol. 2008;53:39-43 pubmed
  50. LaPatra S, Evilia C, Winston V. Positively selected sites on the surface glycoprotein (G) of infectious hematopoietic necrosis virus. J Gen Virol. 2008;89:703-8 pubmed publisher
    Mutations in the surface glycoprotein (G) of infectious hematopoietic necrosis virus (IHNV), a rhabdovirus that causes significant losses in hatcheries raising salmonid fish, were studied...
  51. Peñaranda M, LaPatra S, Kurath G. Specificity of DNA vaccines against the U and M genogroups of infectious hematopoietic necrosis virus (IHNV) in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2011;31:43-51 pubmed publisher
    b>Infectious hematopoietic necrosis virus (IHNV) is a fish rhabdovirus that causes significant mortality in salmonid species. In North America IHNV has three major genogroups designated U, M, and L...
  52. Nita Lazar M, Mancini J, Feng C, González Montalbán N, Ravindran C, Jackson S, et al. The zebrafish galectins Drgal1-L2 and Drgal3-L1 bind in vitro to the infectious hematopoietic necrosis virus (IHNV) glycoprotein and reduce viral adhesion to fish epithelial cells. Dev Comp Immunol. 2016;55:241-252 pubmed publisher
    The infectious hematopoietic necrosis virus (IHNV; Rhabdoviridae, Novirhabdovirus) infects teleost fish, such as salmon and trout, and is responsible for significant losses in the aquaculture industry and in wild fish populations...
  53. Emmenegger E, Kentop E, Thompson T, Pittam S, Ryan A, Keon D, et al. Development of an aquatic pathogen database (AquaPathogen X) and its utilization in tracking emerging fish virus pathogens in North America. J Fish Dis. 2011;34:579-87 pubmed publisher
    ..nacse.org/ihnv/) released in 2006 and the MEAP- viral haemorrhagic septicaemia virus (http://gis.nacse.org/vhsv/) database released in 2010. ..
  54. Garver K, Troyer R, Kurath G. Two distinct phylogenetic clades of infectious hematopoietic necrosis virus overlap within the Columbia River basin. Dis Aquat Organ. 2003;55:187-203 pubmed
    b>Infectious hematopoietic necrosis virus (IHNV), an aquatic rhabdovirus, causes a highly lethal disease of salmonid fish in North America...
  55. Garver K, Conway C, Kurath G. Introduction of translation stop codons into the viral glycoprotein gene in a fish DNA vaccine eliminates induction of protective immunity. Mar Biotechnol (NY). 2006;8:351-6 pubmed
    A highly efficacious DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was mutated to introduce two stop codons to prevent glycoprotein translation while maintaining the plasmid DNA integrity and RNA ..
  56. Wargo A, Scott R, Kerr B, Kurath G. Replication and shedding kinetics of infectious hematopoietic necrosis virus in juvenile rainbow trout. Virus Res. 2017;227:200-211 pubmed publisher
    ..To date, no studies have quantified the shedding kinetics of infectious hematopoietic necrosis virus (IHNV) in rainbow trout (Oncorhynchus mykiss), or how they are associated with replication, ..
  57. Garver K, Conway C, Elliott D, Kurath G. Analysis of DNA-vaccinated fish reveals viral antigen in muscle, kidney and thymus, and transient histopathologic changes. Mar Biotechnol (NY). 2005;7:540-53 pubmed
    A highly efficacious DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was used in a systematic study to analyze vaccine tissue distribution, persistence, expression patterns, and histopathologic ..
  58. Fregeneda Grandes J, Skall H, Olesen N. Antibody response of rainbow trout with single or double infections involving viral haemorrhagic septicaemia virus and infectious haematopoietic necrosis virus. Dis Aquat Organ. 2009;83:23-9 pubmed publisher
    ..Fish in Group 3 developed a double specific antibody reaction whose kinetics and intensity (mean of log10 titres) were similar to the antibody response of the single infected groups. ..
  59. Polinski M, Bradshaw J, Inkpen S, Richard J, Fritsvold C, Poppe T, et al. De novo assembly of Sockeye salmon kidney transcriptomes reveal a limited early response to piscine reovirus with or without infectious hematopoietic necrosis virus superinfection. BMC Genomics. 2016;17:848 pubmed
    ..We further investigate the role of PRV as a coinfecting agent following superinfection with infectious hematopoietic necrosis virus (IHNV) - a highly pathogenic rhabdovirus endemic to the west coast of North America...
  60. Ahmadivand S, Soltani M, Mardani K, Shokrpoor S, Hassanzadeh R, Ahmadpoor M, et al. Infectious hematopoietic necrosis virus (IHNV) outbreak in farmed rainbow trout in Iran: Viral isolation, pathological findings, molecular confirmation, and genetic analysis. Virus Res. 2017;229:17-23 pubmed publisher
    b>Infectious hematopoietic necrosis virus (IHNV) is the etiological agent of a contagious disease (IHN) mainly in salmonid fish...
  61. Lazarte J, Kim Y, Lee J, Im S, Kim S, Jung J, et al. Enhancement of glycoprotein-based DNA vaccine for viral hemorrhagic septicemia virus (VHSV) via addition of the molecular adjuvant, DDX41. Fish Shellfish Immunol. 2017;62:356-365 pubmed publisher
    ..vaccines had been proven to be effective in combating infection against Rhabdovirus (especially infectious hematopoietic necrosis virus, IHNV) in salmonids...
  62. Wiens G, Glenney G, LaPatra S, Welch T. Identification of novel rainbow trout (Onchorynchus mykiss) chemokines, CXCd1 and CXCd2: mRNA expression after Yersinia ruckeri vaccination and challenge. Immunogenetics. 2006;58:308-23 pubmed publisher
    ..CXCd mRNA expression was not increased in rainbow trout infected with infectious hematopoietic necrosis virus, suggesting that up-regulation may be pathogen-specific...
  63. Eder K, Clifford M, Hedrick R, Köhler H, Werner I. Expression of immune-regulatory genes in juvenile Chinook salmon following exposure to pesticides and infectious hematopoietic necrosis virus (IHNV). Fish Shellfish Immunol. 2008;25:508-16 pubmed publisher
    ..of two widely used insecticides, chlorpyrifos (CP) and esfenvalerate (EV), and a pathogen, infectious hematopoietic necrosis virus (IHNV), singly and in combination, on survival and cytokine (Mx protein, IL-1beta, TGF-beta and ..
  64. Rodríguez Saint Jean S, de las Heras A, Carrillo W, Recio I, Ortiz Delgado J, Ramos M, et al. Antiviral activity of casein and ?s2 casein hydrolysates against the infectious haematopoietic necrosis virus, a rhabdovirus from salmonid fish. J Fish Dis. 2013;36:467-81 pubmed publisher
    ..However, the present results provide convincing evidence in support of a role for several milk casein fractions as suitable candidates to prevent and treat some fish viral infections. ..
  65. Müller A, Sutherland B, Koop B, Johnson S, Garver K. Infectious hematopoietic necrosis virus (IHNV) persistence in Sockeye Salmon: influence on brain transcriptome and subsequent response to the viral mimic poly(I:C). BMC Genomics. 2015;16:634 pubmed publisher
    ..A devastating pathogen of Sockeye Salmon is infectious hematopoietic necrosis virus (IHNV, genus Novirhabdovirus, family Rhabdoviridae)...
  66. Hostnik P, Barlic Maganja D, Strancar M, Jencic V, Toplak I, Grom J. Influence of storage temperature on infectious hematopoietic necrosis virus detection by cell culture isolation and RT-PCR methods. Dis Aquat Organ. 2002;52:179-84 pubmed
    The detection of infectious hematopoietic necrosis virus (IHNV) in infected rainbow trout Oncorhynchus mykiss and in cell culture supernatants stored under different conditions was studied...
  67. Briolat V, Jouneau L, Carvalho R, Palha N, Langevin C, Herbomel P, et al. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. J Immunol. 2014;192:4328-41 pubmed publisher
    ..Chikungunya virus (CHIKV) induces a rapid and protective IFN response. Infection with infectious hematopoietic necrosis virus is lethal and is associated with a delayed and inefficient IFN response...
  68. Knüsel R, Bergmann S, Einer Jensen K, Casey J, Segner H, Wahli T. Virus isolation vs RT-PCR: which method is more successful in detecting VHSV and IHNV in fish tissue sampled under field conditions?. J Fish Dis. 2007;30:559-68 pubmed
    ..However, in a titration experiment under laboratory conditions, the sensitivity of RT-PCR was not significantly higher when compared with virus isolation. ..
  69. Suebsing R, Jeon C, Oh M, Kim J. Reverse transcriptase loop-mediated isothermal amplification assay for infectious hematopoietic necrosis virus in Oncorhynchus keta. Dis Aquat Organ. 2011;94:1-8 pubmed publisher
    ..transcriptase loop-mediated isothermal amplification (RT-LAMP) assay was developed for detecting infectious hematopoietic necrosis virus (IHNV) from chum salmon Oncorhynchus keta in South Korea with high specificity, sensitivity and ..
  70. Dhar A, Bowers R, Licon K, LaPatra S. Detection and quantification of infectious hematopoietic necrosis virus in rainbow trout (Oncorhynchus mykiss) by SYBR Green real-time reverse transcriptase-polymerase chain reaction. J Virol Methods. 2008;147:157-66 pubmed
    ..using the fluorogenic dye SYBR Green I was developed for the detection and quantification of infectious hematopoietic necrosis virus (IHNV) infecting rainbow trout (Oncorhynchus mykiss)...
  71. Troyer R, Garver K, Ranson J, Wargo A, Kurath G. In vivo virus growth competition assays demonstrate equal fitness of fish rhabdovirus strains that co-circulate in aquaculture. Virus Res. 2008;137:179-88 pubmed publisher
    ..relative fitness of RNA virus variants in vivo has been developed using the fish rhabdovirus, Infectious hematopoietic necrosis virus (IHNV), in juvenile rainbow trout (Oncorhynchus mykiss)...
  72. Arkush K, Mendonca H, McBride A, Hedrick R. Susceptibility of captive adult winter-run Chinook salmon Oncorhynchus tshawytscha to waterborne exposures with infectious hematopoietic necrosis virus (IHNV). Dis Aquat Organ. 2004;59:211-6 pubmed
    ..Sexually mature female Chinook salmon Oncorhynchus tshawytscha with no prior history of exposure to infectious hematopoietic necrosis virus (IHNV) were susceptible to experimental infection induced by additions of virus to the water...
  73. Kelley G, Garabed R, Branscum A, Perez A, Thurmond M. Prediction model for sequence variation in the glycoprotein gene of infectious hematopoietic necrosis virus in California, U.S.A. Dis Aquat Organ. 2007;78:97-104 pubmed publisher
    The influence of spatio-temporal factors on genetic variation of infectious hematopoietic necrosis virus (IHNV) is an active area of research...
  74. Polinski M, Drennan J, Batts W, Ireland S, Cain K. Establishment and partial characterization of a cell line from burbot Lota lota maculosa: susceptibility to IHNV, IPNV and VHSV. Dis Aquat Organ. 2010;90:15-23 pubmed publisher
    ..The cell line was susceptible to isolates of the M and U North American genotypes of infectious hematopoietic necrosis virus (IHNV), and to isolates of genotypes I, IVa, and IVb of viral hemorrhagic septicemia virus (VHSV)...
  75. de las Heras A, Rodríguez Saint Jean S, Perez Prieto S. Salmonid fish viruses and cell interactions at early steps of the infective cycle. J Fish Dis. 2008;31:535-46 pubmed publisher
    ..It can be affected at several stages of viral infection and is more sensitive to the action of antiviral compounds. ..
  76. Polinski M, Fehringer T, Johnson K, Snekvik K, LaPatra S, LaFrentz B, et al. Characterization of susceptibility and carrier status of burbot, Lota lota (L.), to IHNV, IPNV, Flavobacterium psychrophilum, Aeromonas salmonicida and Renibacterium salmoninarum. J Fish Dis. 2010;33:559-70 pubmed publisher
    ..This study is the first to investigate susceptibility of burbot to selected fish pathogens, and this information will aid in efforts to culture and manage this species. ..
  77. Park J, Moon C, Wargo A, Purcell M, Kurath G. Differential growth of U and M type infectious haematopoietic necrosis virus in a rainbow trout-derived cell line, RTG-2. J Fish Dis. 2010;33:583-91 pubmed publisher
    ..This suggests that host-specific factors in RTG-2 cells control the growth of the IHNV U and M strains differently, leading to growth restriction of the U type virus during the RNA synthesis step...
  78. Jonstrup S, Schuetze H, Kurath G, Gray T, Jensen B, Olesen N. An isolate and sequence database of infectious haematopoietic necrosis virus (IHNV). J Fish Dis. 2010;33:469-71 pubmed publisher
    ..The database is developed, maintained and managed by the European Community Reference Laboratory for Fish Diseases and collaborators. It is available at http://www.fishpathogens.eu/ihnv. ..
  79. Skinner L, LaPatra S, Adams A, Thompson K, Balfry S, McKinley R, et al. Concurrent injection of a rhabdovirus-specific DNA vaccine with a polyvalent, oil-adjuvanted vaccine delays the specific anti-viral immune response in Atlantic salmon, Salmo salar L. Fish Shellfish Immunol. 2010;28:579-86 pubmed publisher
    ..The results indicated that concurrent injection of a polyvalent oil-AV and a DV can be beneficial to the production of antibodies; however, the specific anti-viral response may be delayed. ..
  80. Peeler E, Thrush M. Assessment of exotic fish disease introduction and establishment in the United Kingdom via live fish transporters. Dis Aquat Organ. 2009;83:85-95 pubmed publisher
    ..Changes in the way in which UK-based live fish transporters operate in mainland Europe need to be monitored and development of a code of practice to minimise the risk of disease introduction considered...
  81. Einer Jensen K, Delgado L, Lorenzen E, Bovo G, Evensen Ø, LaPatra S, et al. Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection. Vaccine. 2009;27:1248-53 pubmed publisher
    ..Transfected muscle cells at the injection site expressed both G proteins. This study confirms the applied potential of using a combined DNA vaccination for protection of fish against two different rhabdoviral diseases. ..