bovine ephemeral fever virus

Summary

Summary: The type species of EPHEMEROVIRUS causing disease in cattle. Transmission is by hematophagous arthropods and the virus has been isolated from both culicoides and mosquitoes.

Top Publications

  1. Stram Y, Kuznetzova L, Levin A, Yadin H, Rubinstein Giuni M. A real-time RT-quantative(q)PCR for the detection of bovine ephemeral fever virus. J Virol Methods. 2005;130:1-6 pubmed
    ..By using this system it was shown that as few as 10-100 copies of a viral genome could be detected...
  2. Chang C, Shih W, Yu F, Liao M, Liu H. Apoptosis induced by bovine ephemeral fever virus. J Virol Methods. 2004;122:165-70 pubmed
    The potential significance of bovine ephemeral fever virus (BEFV)-induced apoptosis and involved viral molecules was fully unknown...
  3. Hertig C, Pye A, Hyatt A, Davis S, McWilliam S, Heine H, et al. Vaccinia virus-expressed bovine ephemeral fever virus G but not G(NS) glycoprotein induces neutralizing antibodies and protects against experimental infection. J Gen Virol. 1996;77 ( Pt 4):631-40 pubmed
    Two related glycoproteins (G and G(NS)) encoded in the bovine ephemeral fever virus (BEFV) genome were expressed from recombinant vaccinia viruses (rVV)...
  4. Yeruham I, Sharir B, Yadin H, Tiomkin D, Chai D. Bovine ephemeral fever in beef cattle herds in the Jordan Valley, Israel. Vet Rec. 2003;152:86-8 pubmed
  5. Kirkland P. Akabane and bovine ephemeral fever virus infections. Vet Clin North Am Food Anim Pract. 2002;18:501-14, viii-ix pubmed
    ..In contrast, bovine ephemeral fever virus causes a febrile illness affecting mainly mature animals...
  6. Uren M, Walker P, Zakrzewski H, St George T, Byrne K. Effective vaccination of cattle using the virion G protein of bovine ephemeral fever virus as an antigen. Vaccine. 1994;12:845-50 pubmed
    In a series of experiments, the envelope glycoprotein (G protein) of bovine ephemeral fever virus (BEFV) induced immunity against challenge with virulent virus...
  7. Wang F, Hsu A, Huang K. Bovine ephemeral fever in Taiwan. J Vet Diagn Invest. 2001;13:462-7 pubmed
    ..Both were distinct from 2 Japanese strains and the Australian BB7721 strain. Thus, at least 2 distinct BEF viruses, which had diverged before 1983, existed in Taiwanese dairy cows...
  8. Liao Y, Inaba Y, Li N, Chain C, Lee S, Liou P. Epidemiology of bovine ephemeral fever virus infection in Taiwan. Microbiol Res. 1998;153:289-95 pubmed
    ..We have tried to advise farmers that they must vaccinate their cattle annually to prevent BEF outbreak in the future...
  9. Dhillon J, Cowley J, Wang Y, Walker P. RNA polymerase (L) gene and genome terminal sequences of ephemeroviruses bovine ephemeral fever virus and Adelaide River virus indicate a close relationship to vesiculoviruses. Virus Res. 2000;70:87-95 pubmed
    The sequence of the RNA genome of bovine ephemeral fever virus (BEFV) was determined from the start of the L (polymerase) gene to the end of the untranslated 5' trailer sequence, completing the sequence of the 14900 nucleotide (nt) genome...

More Information

Publications53

  1. Nandi S, Negi B. Bovine ephemeral fever: a review. Comp Immunol Microbiol Infect Dis. 1999;22:81-91 pubmed
    ..In this review, detailed informations of all the aspects of the disease has been provided in a simple, lucid and easily understandable manner...
  2. Hsieh Y, Chen S, Chou C, Ting L, Itakura C, Wang F. Bovine ephemeral fever in Taiwan (2001-2002). J Vet Med Sci. 2005;67:411-6 pubmed
    ..The occurrence of frequent small epizootics implies the dominance of BEF virus over host immunity, but not a variant virus...
  3. Zheng F, Lin G, Qiu C, Zhou J, Cao X, Gong X. Serological detection of bovine ephemeral fever virus using an indirect ELISA based on antigenic site G1 expressed in Pichia pastoris. Vet J. 2010;185:211-5 pubmed publisher
    An indirect ELISA for the serological detection of bovine ephemeral fever virus (BEFV) infection in cattle is described in which a glycosylated protein of approximately 25 kDa (including the G1 antigenic site of the virus glycoprotein) ..
  4. Lin C, Shih W, Lin F, Hsieh Y, Kuo Y, Liao M, et al. Bovine ephemeral fever virus-induced apoptosis requires virus gene expression and activation of Fas and mitochondrial signaling pathway. Apoptosis. 2009;14:864-77 pubmed publisher
    Although induction of apoptosis by bovine ephemeral fever virus (BEFV) in several cell lines has been previously demonstrated by our laboratory, less information is available on the process of BEFV-induced apoptosis in terms of cellular ..
  5. Kato T, Aizawa M, Takayoshi K, Kokuba T, Yanase T, Shirafuji H, et al. Phylogenetic relationships of the G gene sequence of bovine ephemeral fever virus isolated in Japan, Taiwan and Australia. Vet Microbiol. 2009;137:217-23 pubmed publisher
    The G gene encoding the neutralization antigen of bovine ephemeral fever virus (BEFV) was characterized in order to define the virus's molecular epidemiology in Japan and the genetic relationships among the Japanese, Taiwanese and ..
  6. Barigye R, Melville L, Davis S, Walsh S, Hunt N, Hunt R. Kinetics of selected plasma cytokines during innate-adaptive immune response transition in adult cattle infected with the bovine ephemeral fever virus. Vet Microbiol. 2016;186:111-6 pubmed publisher
    ..Ongoing studies will help define the precise role of T cells in anti-BEFV adaptive immune responses. ..
  7. Liu D, Li K, Zhang L, Lan Y, Wang X, Zhang H, et al. Seroprevalence investigation of bovine ephemeral fever in yaks in Tibetan Plateau of China from 2012 to 2015. Trop Anim Health Prod. 2017;49:227-230 pubmed publisher
    Bovine ephemeral fever (BEF) is caused by the arthropod-borne bovine ephemeral fever virus (BEFV), which is classified in family Rhabdoviridae and genus Ephemerovirus...
  8. Chung Y, Shen H, Cheng L, Liu S, Chu C. Effectiveness of a BHV-1/BEFV bivalent vaccine against bovine herpesvirus type 1 infection in cattle. Res Vet Sci. 2016;109:161-165 pubmed publisher
    ..b>Bovine ephemeral fever virus (BEFV) causes acute febrile respiratory disease, with pulmonary emphysema and pulmonary edema as the ..
  9. Venter G, Hamblin C, Paweska J. Determination of the oral susceptibility of South African livestock-associated biting midges, Culicoides species, to bovine ephemeral fever virus. Med Vet Entomol. 2003;17:133-7 pubmed
    ..5 log10 TCID50/ml of bovine ephemeral fever virus (BEFV). Insects were collected during two consecutive summers from two distinct climatic areas...
  10. Zheng F, Lin G, Qiu C, Zhou J, Cao X, Gong X. Development and application of G1-ELISA for detection of antibodies against bovine ephemeral fever virus. Res Vet Sci. 2009;87:211-2 pubmed publisher
    The gene encoding antigenic site G(1) of bovine ephemeral fever virus (BEFV) was highly expressed in the host cell Escherichia coli...
  11. Abayli H, Tonbak S, Azkur A, Bulut H. Complete genome analysis of highly pathogenic bovine ephemeral fever virus isolated in Turkey in 2012. Arch Virol. 2017;162:3233-3238 pubmed publisher
    ..Because of the limited number of complete BEFV genome sequences, the results from this study will be useful for understanding the global molecular epidemiology and geodynamics of BEF. ..
  12. Walker P, Klement E. Epidemiology and control of bovine ephemeral fever. Vet Res. 2015;46:124 pubmed publisher
    ..Caused by an arthropod-borne rhabdovirus, bovine ephemeral fever virus (BEFV), the disease occurs seasonally over a vast expanse of the globe encompassing much of Africa, the ..
  13. Gao S, Du J, Tian Z, Niu Q, Zheng F, Huang D, et al. Complete genome sequence of a bovine ephemeral fever virus JT02L strain in mainland China. Arch Virol. 2017;162:3555-3558 pubmed publisher
    In this study, we report the complete genome sequence of bovine ephemeral fever virus (BEFV) JT02L, which has been used in our laboratory, in mainland China, for more than a decade...
  14. Zheng F, Chen Q, Li Z, Gong X, Wang J, Yin H. Experimental infection with bovine ephemeral fever virus and analysis of its antibody response cattle. Res Vet Sci. 2016;104:146-51 pubmed publisher
    ..However, after 3 or 6months, when nAbs were no longer apparent, re-infected cattle displayed typical symptoms of BEF. Our findings indicated that vaccination should be performed once the titer of nAb decreased to 5 or 6. ..
  15. Ting L, Lee M, Lin Y, Cheng M, Lee F. Invasion of exotic bovine ephemeral fever virus into Taiwan in 2013-2014. Vet Microbiol. 2016;182:15-7 pubmed publisher
    b>Bovine ephemeral fever virus is a member of the family Rhabdoviridae and bovine ephemeral fever has frequently affected cattle population in Taiwan since 1967...
  16. Barigye R, Davis S, Hunt R, Hunt N, Walsh S, Elliott N, et al. Viral neurotropism, peripheral neuropathy and other morphological abnormalities in bovine ephemeral fever virus-infected downer cattle. Aust Vet J. 2016;94:362-70 pubmed publisher
  17. Erster O, Stram R, Menasherow S, Rubistein Giuni M, Sharir B, Kchinich E, et al. High-resolution melting (HRM) for genotyping bovine ephemeral fever virus (BEFV). Virus Res. 2017;229:1-8 pubmed publisher
    ..The new algorithm may therefore be useful for development of improved genotyping studies for other viruses and possibly other microorganisms. ..
  18. Zhang M, Ge J, Wen Z, Chen W, Wang X, Liu R, et al. Characterization of a recombinant Newcastle disease virus expressing the glycoprotein of bovine ephemeral fever virus. Arch Virol. 2017;162:359-367 pubmed publisher
    Bovine ephemeral fever (BEF) is caused by the arthropod-borne bovine ephemeral fever virus (BEFV), which is a member of the family Rhabdoviridae and the genus Ephemerovirus...
  19. Hou P, Zhao G, Wang H, He C, Huan Y, He H. Development of a recombinase polymerase amplification combined with lateral-flow dipstick assay for detection of bovine ephemeral fever virus. Mol Cell Probes. 2018;38:31-37 pubmed publisher
    b>Bovine ephemeral fever virus (BEFV), identified as the causative pathogen of bovine ephemeral fever (BEF), is responsible for increasing numbers of epidemics/outbreaks and has a significant harmful effect on the livestock industry...
  20. Zaghawa A, Housawi F, Al Naeem A, Al Nakhly H, Kamr A, TORIBIO R. Risk analysis and seroprevalence of bovine ephemeral fever virus in cattle in the Kingdom of Saudi Arabia. Trop Anim Health Prod. 2016;48:487-92 pubmed publisher
    b>Bovine ephemeral fever virus (BEFV) is an arthropod-borne rhabdovirus that causes disabling clinical signs and major economic losses in cattle and water buffalo...
  21. Hou P, Zhao G, He C, Wang H, He H. Biopanning of polypeptides binding to bovine ephemeral fever virus G1 protein from phage display peptide library. BMC Vet Res. 2018;14:3 pubmed publisher
    The bovine ephemeral fever virus (BEFV) glycoprotein neutralization site 1 (also referred as G1 protein), is a critical protein responsible for virus infectivity and eliciting immune-protection, however, binding peptides of ..
  22. He C, Liu Y, Wang H, Hou P, He H, Ding N. New genetic mechanism, origin and population dynamic of bovine ephemeral fever virus. Vet Microbiol. 2016;182:50-6 pubmed publisher
    b>Bovine ephemeral fever virus (BEFV) is a typical species of the genusEphemerovirus in the family Rhabdoviridae. Today, prevailing BEFV can be divided into three phylogeographic lineages, East Asia, Mideast, and Australia...
  23. Abu Elzein E, al Afaleq A, Housawi F, Al Basheir A. A study on bovine ephemeral fever involving sentinel herds and serosurveillance in Saudi Arabia. Rev Sci Tech. 2006;25:1147-51 pubmed
    ..The epidemiological situation of the disease in Saudi Arabia is discussed in relation to the likelihood of introduction of the disease into the country. ..
  24. Yazdani F, Bakhshesh M, Esmaelizad M, Sadigh Z. Expression of G1- epitope of bovine ephemeral fever virus in E. coli : A novel candidate to develop ELISA kit. Vet Res Forum. 2017;8:209-213 pubmed
    ..The surface glycoprotein G of bovine ephemeral fever virus (BEFV) is composed of 4 antigenic sites (G1-G4) and plays the main role for eliciting neutralizing ..
  25. Vanselow B, Walthall J, Abetz I. Field trials of ephemeral fever vaccines. Vet Microbiol. 1995;46:117-30 pubmed
    ..Antibody responses were highest for the vaccine incorporating Quil A when it was given as two consecutive injections. There was an apparent relationship between neutralising antibody response and the level of protection...
  26. Chuang S, Ji W, Chen Y, Lin C, Hsieh Y, Liu H. Suppression of bovine ephemeral fever virus by RNA interference. J Virol Methods. 2007;145:84-7 pubmed
    RNA interference (RNAi) was used to suppress bovine ephemeral fever virus (BEFV). Plasmids expressing continuously shRNAs were used against G gene of BEFV to induce RNA interference in cultured cells...
  27. Lim S, Kweon C, Tark D, Kim S, Yang D. Sero-survey on Aino, Akabane, Chuzan, bovine ephemeral fever and Japanese encephalitis virus of cattle and swine in Korea. J Vet Sci. 2007;8:45-9 pubmed
    ..Moreover, we confirmed that JEV could be associated with reproductive failure in pregnant cattle, as were other vector-borne bovine arboviruses assessed in this study...
  28. Abu Elzein E, Gameel A, al Afaleq A, al Gundi O, al Bashier A, Zeedan A, et al. Observations on the recent epizootic of bovine ephemeral fever in Saudi Arabia. Rev Sci Tech. 1999;18:672-80 pubmed
    ..and mosquitoes). To conclude, the authors discuss precautions to prevent future outbreaks of bovine ephemeral fever in Saudi Arabia...
  29. Johal J, Gresty K, Kongsuwan K, Walker P. Antigenic characterization of bovine ephemeral fever rhabdovirus G and GNS glycoproteins expressed from recombinant baculoviruses. Arch Virol. 2008;153:1657-65 pubmed publisher
    ..The highly protective characteristics of the native BEFV G protein suggest that the secreted, baculovirus-expressed product may be a useful vaccine antigen...
  30. Wallace D, Viljoen G. Immune responses to recombinants of the South African vaccine strain of lumpy skin disease virus generated by using thymidine kinase gene insertion. Vaccine. 2005;23:3061-7 pubmed
    ..were generated and selected for homogeneity expressing either the structural glycoprotein gene of bovine ephemeral fever virus (BEFV) or the two structural glycoprotein genes of Rift Valley fever virus (RVFV)...
  31. McWilliam S, Kongsuwan K, Cowley J, Byrne K, Walker P. Genome organization and transcription strategy in the complex GNS-L intergenic region of bovine ephemeral fever rhabdovirus. J Gen Virol. 1997;78 ( Pt 6):1309-17 pubmed
    A 1622 nucleotide region of the bovine ephemeral fever virus (BEFV) genome, located between the second glycoprotein (GNS) gene and the polymerase (L) gene, has been cloned and sequenced in Australian (BB7721) and Chinese (Beijing-1) ..
  32. Kongsuwan K, Cybinski D, Cooper J, Walker P. Location of neutralizing epitopes on the G protein of bovine ephemeral fever rhabdovirus. J Gen Virol. 1998;79 ( Pt 11):2573-81 pubmed
  33. Farag M, al Sukayran A, Mazloum K, al Bukomy A. Epizootics of bovine ephemeral fever on dairy farms in Saudi Arabia. Rev Sci Tech. 1998;17:713-22 pubmed
    ..Serum neutralisation tests, which used a cell culture-adapted vaccine strain of bovine ephemeral fever virus as an antigen, revealed the presence of specific antibodies with significantly increased titres in the ..
  34. Yeruham I, Braverman Y, Yadin H, van Ham M, Chai D, Tiomkin D, et al. Epidemiological investigations of outbreaks of bovine ephemeral fever in Israel. Vet Rec. 2002;151:117-21 pubmed
    ..The vector(s) is not known for certain but the available evidence indicates that mosquitoes, and not Culicoides species, are the natural vectors of BEF virus in Israel...
  35. Yeruham I, van Ham M, Bar D, Yadin H, Tiomkin D. Economic aspects of the 1999 outbreak of bovine ephemeral fever in dairy cattle herds in the Jordan Valley in Israel. Vet Rec. 2003;153:180-2 pubmed
  36. Hsieh Y, Chen S, Chou C, Hsiao H, Chen S, Lee Y, et al. Development of a reliable assay protocol for identification of diseases (RAPID)-bioactive amplification with probing (BAP) for detection of bovine ephemeral fever virus. J Virol Methods. 2005;129:75-82 pubmed
    ..specific assay, RAPID-BAP assay, was developed to detect and quantify the G protein-encoding gene of bovine ephemeral fever virus (BEFV). This new technique uses a nested PCR and magnetic bead-based DNA probing assay...
  37. Walker P. Bovine ephemeral fever in Australia and the world. Curr Top Microbiol Immunol. 2005;292:57-80 pubmed
    ..b>Bovine ephemeral fever virus (BEFV) has been classified as the type species of the genus Ephemerovirus in the Rhabdoviridae...
  38. Hsieh Y, Wang S, Lee Y, Chen S, Mak P, Chu C. DNA sequence analysis of glycoprotein G gene of bovine ephemeral fever virus and development of a double oil emulsion vaccine against bovine ephemeral fever. J Vet Med Sci. 2006;68:543-8 pubmed
    The surface glycoprotein G is considered as the major neutralizing and protective antigen of bovine ephemeral fever virus (BEFV)...
  39. Wallace D, Weyer J, Nel L, Viljoen G. Improved method for the generation and selection of homogeneous lumpy skin disease virus (SA-Neethling) recombinants. J Virol Methods. 2007;146:52-60 pubmed
    ..method for generation and selection of recombinants described, three different LSDV recombinants expressing the glycoprotein genes of bovine ephemeral fever virus, Rift Valley fever virus and rabies virus were prepared and characterised.
  40. Anderson E, Rowe L. The prevalence of antibody to the viruses of bovine virus diarrhoea, bovine herpes virus 1, rift valley fever, ephemeral fever and bluetongue and to Leptospira sp in free-ranging wildlife in Zimbabwe. Epidemiol Infect. 1998;121:441-9 pubmed
    ..Both BEF and BT were widespread in all the species examined. Evidence of infection with Leptospira sp. was found in 7 species. Infections were due to up to 3 of 8 different serovars...
  41. Finlaison D, Read A, Kirkland P. An epizootic of bovine ephemeral fever in New South Wales in 2008 associated with long-distance dispersal of vectors. Aust Vet J. 2010;88:301-6 pubmed publisher
  42. Chen C, Chang C, Liu H, Liao M, Chang C, Hsu J, et al. Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways. Vet Res. 2010;41:15 pubmed publisher
    Our previous report demonstrated that bovine ephemeral fever virus (BEFV)-infected cultured cells could induce caspase-dependent apoptosis. This study aims to further elucidate how BEFV activates the caspase cascade in bovine cells...
  43. Daniels P, Sendow I, Soleha E, Sukarsih -, Hunt N, Bahri S. Australian-Indonesian collaboration in veterinary arbovirology--a review. Vet Microbiol. 1995;46:151-74 pubmed
    ..Their patterns of mobility among countries in the region are largely undescribed, but there are opportunities for further regional collaboration...
  44. Zheng F, Lin G, Qiu C. [Expression, purification and antigenic characterization of the Epitope-G1 gene of bovine ephemeral fever virus in Escherichia coli]. Wei Sheng Wu Xue Bao. 2007;47:498-502 pubmed
    The epitope-G1 gene, cloned from the pMD-G plasmid including G protein gene of bovine ephemeral fever virus (BEFV), was subcloned into expression vector pGEX-4T-1 to construct pGEX-G1 recombinant plasmid successfully...