bovine respiratory syncytial virus

Summary

Summary: A species of PNEUMOVIRUS causing an important respiratory infection in cattle. Symptoms include fever, conjunctivitis, and respiratory distress.

Top Publications

  1. Mawhinney I, Burrows M. Protection against bovine respiratory syncytial virus challenge following a single dose of vaccine in young calves with maternal antibody. Vet Rec. 2005;156:139-43 pubmed
    Twenty-one young calves with maternally derived antibody to bovine respiratory syncytial virus (BRSV) were divided into three groups of seven, each group balanced for BRSV antibody titre...
  2. Taylor G, Thomas L, Furze J, Cook R, Wyld S, Lerch R, et al. Recombinant vaccinia viruses expressing the F, G or N, but not the M2, protein of bovine respiratory syncytial virus (BRSV) induce resistance to BRSV challenge in the calf and protect against the development of pneumonic lesions. J Gen Virol. 1997;78 ( Pt 12):3195-206 pubmed
    ..efficacy of recombinant vaccinia viruses (rVV) encoding the F, G, N or M2 (22K) proteins of bovine respiratory syncytial virus (BRSV) were evaluated in calves, the natural host for BRSV...
  3. Tjørnehøj K, Uttenthal A, Viuff B, Larsen L, Røntved C, Rønsholt L. An experimental infection model for reproduction of calf pneumonia with bovine respiratory syncytial virus (BRSV) based on one combined exposure of calves. Res Vet Sci. 2003;74:55-65 pubmed
    b>Bovine respiratory syncytial virus (BRSV) has been recognised as an important pathogen in calf pneumonia for 30 years, but surprisingly few effective infection models for studies of the immune response and the pathogenesis in the natural ..
  4. Gershwin L, Schelegle E, Gunther R, Anderson M, Woolums A, LaRochelle D, et al. A bovine model of vaccine enhanced respiratory syncytial virus pathophysiology. Vaccine. 1998;16:1225-36 pubmed
    ..Our model of RSV enhanced disease is important because it provides quantifiable evidence of disease severity that can be applied to evaluate the mechanisms of immunopathology and the safety of candidate RSV vaccines. ..
  5. Elvander M, Baule C, Persson M, Egyed L, Ballagi Pordány A, Belak S, et al. An experimental study of a concurrent primary infection with bovine respiratory syncytial virus (BRSV) and bovine viral diarrhoea virus (BVDV) in calves. Acta Vet Scand. 1998;39:251-64 pubmed
    Experimental infections with bovine respiratory syncytial virus (BRSV) and bovine viral diarrhoea virus (BVDV) were performed to study the effect of concurrent BRSV and BVDV infections...
  6. Berghaus L, Corbeil L, Berghaus R, Kalina W, Kimball R, Gershwin L. Effects of dual vaccination for bovine respiratory syncytial virus and Haemophilus somnus on immune responses. Vaccine. 2006;24:6018-27 pubmed
    b>Bovine respiratory syncytial virus (BRSV) and Haemophilus somnus (H. somnus) co-infect to form a polymicrobial respiratory disease in calves. Both BRSV and H...
  7. Beaudeau F, Ohlson A, Emanuelson U. Associations between bovine coronavirus and bovine respiratory syncytial virus infections and animal performance in Swedish dairy herds. J Dairy Sci. 2010;93:1523-33 pubmed publisher
    To assess the economic impact of bovine coronavirus (BCV) and bovine respiratory syncytial virus (BRSV) infections, accurate estimates of their associated effects on animal performance are needed...
  8. Fulton R, Purdy C, Confer A, Saliki J, Loan R, Briggs R, et al. Bovine viral diarrhea viral infections in feeder calves with respiratory disease: interactions with Pasteurella spp., parainfluenza-3 virus, and bovine respiratory syncytial virus. Can J Vet Res. 2000;64:151-9 pubmed
    ..antibodies to BVDV types 1 and 2, bovine herpesvirus-1 (BHV-1), parainfluenza-3 virus (PI-3V), and bovine respiratory syncytial virus (BRSV)...
  9. Mars M, Bruschke C, van Oirschot J. Airborne transmission of BHV1, BRSV, and BVDV among cattle is possible under experimental conditions. Vet Microbiol. 1999;66:197-207 pubmed
    To control the diseases caused by bovine herpesvirus 1 (BHV1), bovine respiratory syncytial virus (BRSV), and bovine virus diarrhoea virus (BVDV), it is crucial to know their modes of transmission...

More Information

Publications98

  1. Norstrom M, Skjerve E, Jarp J. Risk factors for epidemic respiratory disease in Norwegian cattle herds. Prev Vet Med. 2000;44:87-96 pubmed
    An epidemic of acute respiratory disease associated with bovine respiratory syncytial virus (BRSV) occurred during the winter and spring of 1995 in two neighbouring veterinary districts in the south-eastern part of Norway...
  2. Oumouna M, Mapletoft J, Karvonen B, Babiuk L, van Drunen Littel van den Hurk S. Formulation with CpG oligodeoxynucleotides prevents induction of pulmonary immunopathology following priming with formalin-inactivated or commercial killed bovine respiratory syncytial virus vaccine. J Virol. 2005;79:2024-32 pubmed
    Commercial killed bovine respiratory syncytial virus (K-BRSV) and formalin-inactivated BRSV (FI-BRSV) tend to induce Th2-type immune responses, which may not be protective and may even be detrimental during subsequent exposure to the ..
  3. Ohlson A, Emanuelson U, Tråvén M, Alenius S. The relationship between antibody status to bovine corona virus and bovine respiratory syncytial virus and disease incidence, reproduction and herd characteristics in dairy herds. Acta Vet Scand. 2010;52:37 pubmed publisher
    b>Bovine respiratory syncytial virus (BRSV) and bovine corona virus (BCV) affects cattle worldwide...
  4. Cristina J, Yunus A, Rockemann D, Samal S. Bovine respiratory syncytial virus can induce apoptosis in MDBK cultured cells. Vet Microbiol. 2001;83:317-20 pubmed
    b>Bovine respiratory syncytial virus (BRSV) is a major cause of respiratory disease in calves. BRSV infection is associated with epithelial cell death and inflammation...
  5. Brodersen B. Bovine respiratory syncytial virus. Vet Clin North Am Food Anim Pract. 2010;26:323-33 pubmed publisher
    b>Bovine respiratory syncytial virus (BRSV) is a major cause of respiratory disease and a major contributor to the bovine respiratory disease (BRD) complex. BRSV infects the upper and lower respiratory tract and is shed in nasal secretions...
  6. Grubbs S, Kania S, Potgieter L. Prevalence of ovine and bovine respiratory syncytial virus infections in cattle determined with a synthetic peptide-based immunoassay. J Vet Diagn Invest. 2001;13:128-32 pubmed
    ..Subgroup-specific peptide-based enzyme-linked immunosorbent assays from the G-protein of the ovine and bovine respiratory syncytial virus (RSV), respectively, were used to determine the prevalence of the ovine and bovine subgroup strains ..
  7. Uttenthal A, Larsen L, Philipsen J, Tjørnehøj K, Viuff B, Nielsen K, et al. Antibody dynamics in BRSV-infected Danish dairy herds as determined by isotype-specific immunoglobulins. Vet Microbiol. 2000;76:329-41 pubmed
    Using specific ELISAs, antibody levels of four different isotypes to bovine respiratory syncytial virus (BRSV) were determined in calves, following experimental BRSV infection...
  8. Patel J. Evaluation of a quadrivalent inactivated vaccine for the protection of cattle against diseases due to common viral infections. J S Afr Vet Assoc. 2004;75:137-46 pubmed
    ..IBR) virus, parainfluenza type 3 (PI3) virus, bovine virus diarrhoea virus (BVDV) and bovine respiratory syncytial virus (BRSV) was assessed in naive bovine calves to evaluate short-term (4-18 weeks) and long-term (24-38 ..
  9. Karger A, Schmidt U, Buchholz U. Recombinant bovine respiratory syncytial virus with deletions of the G or SH genes: G and F proteins bind heparin. J Gen Virol. 2001;82:631-40 pubmed
    b>Bovine respiratory syncytial virus (BRSV) encodes three transmembrane envelope glycoproteins, namely the small hydrophobic (SH) protein, the attachment glycoprotein (G) and the fusion glycoprotein (F)...
  10. Buchholz U, Finke S, Conzelmann K. Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter. J Virol. 1999;73:251-9 pubmed
    In order to generate recombinant bovine respiratory syncytial virus (BRSV), the genome of BRSV strain A51908, variant ATue51908, was cloned as cDNA. We provide here the sequence of the BRSV genome ends and of the entire L gene...
  11. Schmidt U, Beyer J, Polster U, Gershwin L, Buchholz U. Mucosal immunization with live recombinant bovine respiratory syncytial virus (BRSV) and recombinant BRSV lacking the envelope glycoprotein G protects against challenge with wild-type BRSV. J Virol. 2002;76:12355-9 pubmed
    Recombinant bovine respiratory syncytial virus (rBRSV) and an rBRSV deletion mutant lacking the G gene (rBRSVDeltaG) were characterized in calves with respect to replication competence, attenuation, and protective efficacy as live-..
  12. Khattar S, Yunus A, Collins P, Samal S. Deletion and substitution analysis defines regions and residues within the phosphoprotein of bovine respiratory syncytial virus that affect transcription, RNA replication, and interaction with the nucleoprotein. Virology. 2001;285:253-69 pubmed
    The phosphoprotein (P) of bovine respiratory syncytial virus (BRSV) is a multifunctional protein that plays a central role in transcription and replication of the viral genomic RNA...
  13. Valentova V, Psikal I, Kovarcik K. Demonstration of bovine respiratory syncytial virus RNA in peripheral blood leukocytes of naturally infected cattle. Acta Virol. 2003;47:33-6 pubmed
    RNA of Bovine respiratory syncytial virus (BRSV) was found in peripheral leukocytes and nasal mucosa of infected cows by nested reverse transcription-polymerase chain reaction (nRT-PCR)...
  14. Gershwin L, Berghaus L, Arnold K, Anderson M, Corbeil L. Immune mechanisms of pathogenetic synergy in concurrent bovine pulmonary infection with Haemophilus somnus and bovine respiratory syncytial virus. Vet Immunol Immunopathol. 2005;107:119-30 pubmed
    b>Bovine respiratory syncytial virus (BRSV) and Haemophilus somnus are two bovine respiratory pathogens that cause disease singly or as part of a polymicrobial infection...
  15. Ellis J, Gow S, West K, Waldner C, Rhodes C, Mutwiri G, et al. Response of calves to challenge exposure with virulent bovine respiratory syncytial virus following intranasal administration of vaccines formulated for parenteral administration. J Am Vet Med Assoc. 2007;230:233-43 pubmed
    To determine whether single-fraction and combination modified-live bovine respiratory syncytial virus (BRSV) vaccines commercially licensed for parenteral administration could stimulate protective immunity in calves after intranasal ..
  16. Boxus M, Tignon M, Roels S, Toussaint J, Walravens K, Benoit M, et al. DNA immunization with plasmids encoding fusion and nucleocapsid proteins of bovine respiratory syncytial virus induces a strong cell-mediated immunity and protects calves against challenge. J Virol. 2007;81:6879-89 pubmed
    ..These results indicate that DNA vaccination could be a promising alternative to the classical vaccines against RSV in cattle and could therefore open perspectives for vaccinating young infants. ..
  17. Luzzago C, Bronzo V, Salvetti S, Frigerio M, Ferrari N. Bovine respiratory syncytial virus seroprevalence and risk factors in endemic dairy cattle herds. Vet Res Commun. 2010;34:19-24 pubmed publisher
    The herd seroprevalence of bovine respiratory syncytial virus (BRSV) was studied in 59 dairy cattle herds using serology on random selected animals stratified by two age classes (heifers, cows)...
  18. Ellis J, Gow S, Goji N. Response to experimentally induced infection with bovine respiratory syncytial virus following intranasal vaccination of seropositive and seronegative calves. J Am Vet Med Assoc. 2010;236:991-9 pubmed publisher
    To determine whether a combination modified-live bovine respiratory syncytial virus (BRSV) vaccine can stimulate protective immunity in young BRSV-seropositive calves following intranasal (IN) administration. Controlled challenge study...
  19. Valarcher J, Taylor G. Bovine respiratory syncytial virus infection. Vet Res. 2007;38:153-80 pubmed
    b>Bovine respiratory syncytial virus (BRSV) belongs to the pneumovirus genus within the family Paramyxoviridae and is a major cause of respiratory disease in young calves...
  20. Viuff B, Tjørnehøj K, Larsen L, Røntved C, Uttenthal A, Rønsholt L, et al. Replication and clearance of respiratory syncytial virus: apoptosis is an important pathway of virus clearance after experimental infection with bovine respiratory syncytial virus. Am J Pathol. 2002;161:2195-207 pubmed
    ..Similarly, bovine respiratory syncytial virus (BRSV) is causing severe, sometimes fatal, respiratory disease in calves...
  21. Mapletoft J, Latimer L, Babiuk L, van Drunen Littel van den Hurk S. Intranasal immunization of mice with a bovine respiratory syncytial virus vaccine induces superior immunity and protection compared to those by subcutaneous delivery or combinations of intranasal and subcutaneous prime-boost strategies. Clin Vaccine Immunol. 2010;17:23-35 pubmed publisher
    b>Bovine respiratory syncytial virus (BRSV) infects cells of the respiratory mucosa, so it is desirable to develop a vaccination strategy that induces mucosal immunity...
  22. Elvander M, Vilcek S, Baule C, Uttenthal A, Ballagi Pordány A, Belak S. Genetic and antigenic analysis of the G attachment protein of bovine respiratory syncytial virus strains. J Gen Virol. 1998;79 ( Pt 12):2939-46 pubmed
    Antigenic and genetic studies of bovine respiratory syncytial virus (BRSV) were made on isolates obtained from three continents over 27 years...
  23. Woolums A, Brown C, Brown J, Cole D, Scott M, Williams S, et al. Effects of a single intranasal dose of modified-live bovine respiratory syncytial virus vaccine on resistance to subsequent viral challenge in calves. Am J Vet Res. 2004;65:363-72 pubmed
    To determine whether a single intranasal dose of modified-live bovine respiratory syncytial virus (BRSV) vaccine protects calves from BRSV challenge and characterize cell-mediated immune response in calves following BRSV challenge...
  24. Xue W, Ellis J, Mattick D, Smith L, Brady R, Trigo E. Immunogenicity of a modified-live virus vaccine against bovine viral diarrhea virus types 1 and 2, infectious bovine rhinotracheitis virus, bovine parainfluenza-3 virus, and bovine respiratory syncytial virus when administered intranasally in young c. Vaccine. 2010;28:3784-92 pubmed publisher
    ..types 1 and 2, infectious bovine rhinotracheitis (IBR) virus, parainfluenza-3 (PI-3) virus and bovine respiratory syncytial virus (BRSV)...
  25. Khattar S, Yunus A, Samal S. Mapping the domains on the phosphoprotein of bovine respiratory syncytial virus required for N-P and P-L interactions using a minigenome system. J Gen Virol. 2001;82:775-9 pubmed
    The interaction of bovine respiratory syncytial virus (BRSV) phosphoprotein (P) with nucleocapsid (N) and large polymerase (L) proteins was investigated using an intracellular BRSV-CAT minigenome replication system...
  26. Heegaard P, Godson D, Toussaint M, Tjørnehøj K, Larsen L, Viuff B, et al. The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus. Vet Immunol Immunopathol. 2000;77:151-9 pubmed
    ..This was studied in a bovine model for infection with bovine respiratory syncytial virus (BRSV), analysing the induction of the two most dominant bovine acute phase proteins haptoglobin and ..
  27. Fogg M, Parsons K, Thomas L, Taylor G. Identification of CD4+ T cell epitopes on the fusion (F) and attachment (G) proteins of bovine respiratory syncytial virus (BRSV). Vaccine. 2001;19:3226-40 pubmed
    ..The finding that there was little recognition of the extracellular domain of the G protein by T cells has important implications for vaccine design based on the soluble form of this protein. ..
  28. Kerkhofs P, Tignon M, Petry H, Mawhinney I, Sustronck B. Immune responses to bovine respiratory syncytial virus (BRSV) following use of an inactivated BRSV-PI3-Mannheimia haemolytica vaccine and a modified live BRSV-BVDV vaccine. Vet J. 2004;167:208-10 pubmed
  29. Kovacs Nolan J, Mapletoft J, Lawman Z, Babiuk L, van Drunen Littel van den Hurk S. Formulation of bovine respiratory syncytial virus fusion protein with CpG oligodeoxynucleotide, cationic host defence peptide and polyphosphazene enhances humoral and cellular responses and induces a protective type 1 immune response in mice. J Gen Virol. 2009;90:1892-905 pubmed publisher
  30. Zimmer G, Rohn M, McGregor G, Schemann M, Conzelmann K, Herrler G. Virokinin, a bioactive peptide of the tachykinin family, is released from the fusion protein of bovine respiratory syncytial virus. J Biol Chem. 2003;278:46854-61 pubmed
    ..We show here that furin-mediated cleavage of the bovine respiratory syncytial virus fusion protein results in the release of a peptide that is converted into a biologically active ..
  31. Buchholz U, Granzow H, Schuldt K, Whitehead S, Murphy B, Collins P. Chimeric bovine respiratory syncytial virus with glycoprotein gene substitutions from human respiratory syncytial virus (HRSV): effects on host range and evaluation as a live-attenuated HRSV vaccine. J Virol. 2000;74:1187-99 pubmed
    We recently developed a system for the generation of infectious bovine respiratory syncytial virus (BRSV) from cDNA...
  32. van der Sluijs M, Kuhn E, Makoschey B. A single vaccination with an inactivated bovine respiratory syncytial virus vaccine primes the cellular immune response in calves with maternal antibody. BMC Vet Res. 2010;6:2 pubmed publisher
    The efficacy of a single dose of an inactivated bovine respiratory syncytial virus (BRSV)--Parainfluenaza type 3 (PI3)--Mannheimia haemolytica (Mh) combination vaccine, in calves positive for maternal antibodies, was established in a BRSV ..
  33. Larsen L, Tegtmeier C, Pedersen E. Bovine respiratory syncytial virus (BRSV) pneumonia in beef calf herds despite vaccination. Acta Vet Scand. 2001;42:113-21 pubmed
    ..The calves had been vaccinated with an inactivated bovine respiratory syncytial virus (BRSV) vaccine 2 months prior to the outbreak...
  34. Bidokhti M, Tråvén M, Fall N, Emanuelson U, Alenius S. Reduced likelihood of bovine coronavirus and bovine respiratory syncytial virus infection on organic compared to conventional dairy farms. Vet J. 2009;182:436-40 pubmed publisher
    The prevalence of antibodies to bovine coronavirus (BCV) and bovine respiratory syncytial virus (BRSV) infections was studied in 20 conventional and 20 organic dairy herds...
  35. O Neill R, Woolliams J, Glass E, Williams J, Fitzpatrick J. Quantitative evaluation of genetic and environmental parameters determining antibody response induced by vaccination against bovine respiratory syncytial virus. Vaccine. 2006;24:4007-16 pubmed
    The parameters controlling IgG antibody responses induced by vaccination against bovine respiratory syncytial virus (BRSV) were investigated in 463 Holstein-Charolais crossbred cattle...
  36. Ohlson A, Heuer C, Lockhart C, Tråvén M, Emanuelson U, Alenius S. Risk factors for seropositivity to bovine coronavirus and bovine respiratory syncytial virus in dairy herds. Vet Rec. 2010;167:201-6 pubmed publisher
    ..characteristics, management routines and farm-level antibody status of bovine coronavirus (BCV) and bovine respiratory syncytial virus (BRSV) in 257 Swedish dairy herds...
  37. Boxus M, Letellier C, Kerkhofs P. Real Time RT-PCR for the detection and quantitation of bovine respiratory syncytial virus. J Virol Methods. 2005;125:125-30 pubmed
    A quantitative Real Time RT-PCR assay was developed to detect and quantify bovine respiratory syncytial virus (BRSV) in the respiratory tract of infected animals...
  38. Yaegashi G, Seimiya Y, Seki Y, Tsunemitsu H. Genetic and antigenic analyses of bovine respiratory syncytial virus detected in Japan. J Vet Med Sci. 2005;67:145-50 pubmed
    Genetic and antigenic analyses of bovine respiratory syncytial virus were conducted on 12 field strains from Tohoku and Hokuriku districts in Japan during from 2002 to 2004...
  39. Solís Calderón J, Segura Correa J, Aguilar Romero F, Segura Correa V. Detection of antibodies and risk factors for infection with bovine respiratory syncytial virus and parainfluenza virus-3 in beef cattle of Yucatan, Mexico. Prev Vet Med. 2007;82:102-10 pubmed
    ..to determine the antibody seroprevalences (in an indirect enzyme-linked inmunosorbance assay) to bovine respiratory syncytial virus (BRSV) and risk factors for animal-level seropositivity...
  40. Fach S, Meyerholz D, Gallup J, Ackermann M, Lehmkuhl H, Sacco R. Neonatal ovine pulmonary dendritic cells support bovine respiratory syncytial virus replication with enhanced interleukin (IL)-4 And IL-10 gene transcripts. Viral Immunol. 2007;20:119-30 pubmed
    ..Overall, these findings are the first to demonstrate that neonatal lung DCs support in vivo BRSV replication and produce type II cytokines after viral infection. ..
  41. Larsen L, Uttenthal A, Arctander P, Tjørnehøj K, Viuff B, Røntved C, et al. Serological and genetic characterisation of bovine respiratory syncytial virus (BRSV) indicates that Danish isolates belong to the intermediate subgroup: no evidence of a selective effect on the variability of G protein nucleotide sequence by prior c. Vet Microbiol. 1998;62:265-79 pubmed
    Danish isolates of bovine respiratory syncytial virus (BRSV) were characterised by nucleotide sequencing of the G glycoprotein and by their reactivity with a panel of monoclonal antibodies (MAbs)...
  42. Antonis A, Claassen E, Hensen E, de Groot R, de Groot Mijnes J, Schrijver R, et al. Kinetics of antiviral CD8 T cell responses during primary and post-vaccination secondary bovine respiratory syncytial virus infection. Vaccine. 2006;24:1551-61 pubmed
    We have measured antiviral CD8 T cells responses in bovine respiratory syncytial virus (bRSV) infected calves that had been immunized with either formalin-inactivated (FI) or live-attenuated (L) bRSV, with evidence of immunopathology ..
  43. Larsen L. Bovine respiratory syncytial virus (BRSV): a review. Acta Vet Scand. 2000;41:1-24 pubmed
    b>Bovine respiratory syncytial virus (BRSV) infection is the major cause of respiratory disease in calves during the first year of life. The study of the virus has been difficult because of its lability and very poor growth in cell culture...
  44. Taylor G, Bruce C, Barbet A, Wyld S, Thomas L. DNA vaccination against respiratory syncytial virus in young calves. Vaccine. 2005;23:1242-50 pubmed
    A DNA vaccine encoding the fusion (F) gene (DNA-F) of bovine respiratory syncytial virus (BRSV) induced significant protection against BRSV infection in young calves...
  45. Gershwin L, Gunther R, Hornof W, Larson R. Effect of infection with bovine respiratory syncytial virus on pulmonary clearance of an inhaled antigen in calves. Am J Vet Res. 2008;69:416-22 pubmed publisher
    To evaluate the effect of infection with bovine respiratory syncytial virus (BRSV) on clearance of inhaled antigens from the lungs of calves. Eleven 6- to 8-week-old Holstein bull calves...
  46. Peters A, Thevasagayam S, Wiseman A, Salt J. Duration of immunity of a quadrivalent vaccine against respiratory diseases caused by BHV-1, PI3V, BVDV, and BRSV in experimentally infected calves. Prev Vet Med. 2004;66:63-77 pubmed
    ..type-1 (BHV-1), parainfluenza type-3 virus (PI3V), bovine viral-diarrhoea virus type 1 (BVDV), or bovine respiratory syncytial virus (BRSV)...
  47. Thomas L, Cook R, Wyld S, Furze J, Taylor G. Passive protection of gnotobiotic calves using monoclonal antibodies directed at different epitopes on the fusion protein of bovine respiratory syncytial virus. J Infect Dis. 1998;177:874-80 pubmed
    ..Syncytia were markedly absent, and little or no viral antigen was detected in either the B4- or B13-treated calves. ..
  48. West K, Petrie L, Konoby C, Haines D, Cortese V, Ellis J. The efficacy of modified-live bovine respiratory syncytial virus vaccines in experimentally infected calves. Vaccine. 1999;18:907-19 pubmed
    The efficacy of modified-live (MLV) bovine respiratory syncytial virus (BRSV) vaccines and the correlates of vaccine-induced immunity were investigated in calves using a virulent experimental infection...
  49. Stope M, Karger A, Schmidt U, Buchholz U. Chimeric bovine respiratory syncytial virus with attachment and fusion glycoproteins replaced by bovine parainfluenza virus type 3 hemagglutinin-neuraminidase and fusion proteins. J Virol. 2001;75:9367-77 pubmed
    ..Thus, the envelope glycoproteins derived from a member of the Respirovirus genus can together functionally replace their homologs in a Pneumovirus background. ..
  50. Vangeel I, Antonis A, Fluess M, Riegler L, Peters A, Harmeyer S. Efficacy of a modified live intranasal bovine respiratory syncytial virus vaccine in 3-week-old calves experimentally challenged with BRSV. Vet J. 2007;174:627-35 pubmed
    Two experimental bovine respiratory syncytial virus (BRSV) challenge studies were undertaken to evaluate the efficacy of a single intranasal dose of a bivalent modified live vaccine containing BRSV in 3-week-old calves...
  51. Antonis A, Schrijver R, Daus F, Steverink P, Stockhofe N, Hensen E, et al. Vaccine-induced immunopathology during bovine respiratory syncytial virus infection: exploring the parameters of pathogenesis. J Virol. 2003;77:12067-73 pubmed
    ..In this report, we describe a bovine respiratory syncytial virus (bRSV) challenge model in which both classical bRSV respiratory infection and vaccine-enhanced ..
  52. Langedijk J, Meloen R, Taylor G, Furze J, van Oirschot J. Antigenic structure of the central conserved region of protein G of bovine respiratory syncytial virus. J Virol. 1997;71:4055-61 pubmed
    ..for nine monoclonal antibodies (MAbs) directed against the central conserved region of protein G of bovine respiratory syncytial virus (BRSV-G)...
  53. Taylor G, Rijsewijk F, Thomas L, Wyld S, Gaddum R, Cook R, et al. Resistance to bovine respiratory syncytial virus (BRSV) induced in calves by a recombinant bovine herpesvirus-1 expressing the attachment glycoprotein of BRSV. J Gen Virol. 1998;79 ( Pt 7):1759-67 pubmed
    The ability of a bovine herpesvirus-1 (BHV-1) recombinant expressing the G protein of bovine respiratory syncytial virus (BRSV) to protect against BRSV infection was examined in calves...
  54. Willoughby K, Thomson K, Maley M, Gilray J, Scholes S, Howie F, et al. Development of a real time reverse transcriptase polymerase chain reaction for the detection of bovine respiratory syncytial virus in clinical samples and its comparison with immunohistochemistry and immunofluorescence antibody testing. Vet Microbiol. 2008;126:264-70 pubmed
    b>Bovine respiratory syncytial virus is an agent involved in calf pneumonia complex, a disease of significant economic importance...
  55. Hägglund S, Hu K, Larsen L, Hakhverdyan M, Valarcher J, Taylor G, et al. Bovine respiratory syncytial virus ISCOMs--protection in the presence of maternal antibodies. Vaccine. 2004;23:646-55 pubmed
    The protection induced by immunostimulating complexes (ISCOMs) against bovine respiratory syncytial virus (BRSV) was evaluated and compared to that of a commercial inactivated vaccine (CV) in calves with BRSV-specific maternal antibodies...
  56. Valentova V, Antonis A, Kovarcik K. Restriction enzyme analysis of RT-PCR amplicons as a rapid method for detection of genetic diversity among bovine respiratory syncytial virus isolates. Vet Microbiol. 2005;108:1-12 pubmed
    Our current knowledge of antigenic variability of the bovine respiratory syncytial virus (BRSV) is quite limited and is mainly dependent on the use of monoclonal antibodies (mAb)...
  57. Hamers C, Juillard V, Fischer L. DNA vaccination against pseudorabies virus and bovine respiratory syncytial virus infections of young animals in the face of maternally derived immunity. J Comp Pathol. 2007;137 Suppl 1:S35-41 pubmed
    ..The bovine respiratory syncytial virus (BRSV) infection model in young calves was similarly studied, however the ability of DNA vaccination ..
  58. Purtle L, Mattick D, Schneider C, Smith L, Xue W, Trigo E. One year duration of immunity of the modified live bovine viral diarrhea virus type 1 and type 2 and bovine herpesvirus-1 fractions of Vista® Once SQ vaccine. Vaccine. 2016;34:1582-1588 pubmed publisher
    ..Vista® Once SQ (Vista®) vaccine contains five modified-live viruses, BVDV-1, BVDV-2, BHV-1, bovine respiratory syncytial virus, and bovine parainfluenza 3 virus, and two modified-live bacteria, Pasteurella multocida and ..
  59. Palomares R, Hurley D, Bittar J, Saliki J, Woolums A, Moliere F, et al. Effects of injectable trace minerals on humoral and cell-mediated immune responses to Bovine viral diarrhea virus, Bovine herpes virus 1 and Bovine respiratory syncytial virus following administration of a modified-live virus vaccine in dairy calves. Vet Immunol Immunopathol. 2016;178:88-98 pubmed publisher
  60. Taylor G, Thom M, Capone S, Pierantoni A, Guzman E, Herbert R, et al. Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections. Sci Transl Med. 2015;7:300ra127 pubmed publisher
    ..There was no evidence either of enhanced pulmonary pathology or of enhanced respiratory disease in vaccinated calves after BRSV challenge. These findings support the continued evaluation of the vectored RSV vaccines in man. ..
  61. Grubbs S, Kania S, Potgieter L. Validation of synthetic peptide enzyme immunoassays in differentiating two subgroups of ruminant respiratory syncytial virus. J Vet Diagn Invest. 2001;13:123-7 pubmed
    ..peptide-based enzyme immunoassays from each respective G-glycoprotein of the ovine and the bovine respiratory syncytial virus (RSV) were developed to detect RSV-specific IgG responses in cattle...
  62. Kovarcik K, Valentova V. Bovine respiratory syncytial virus strains currently circulating in the Czech Republic are most closely related to Danish strains from 1995. Acta Virol. 2004;48:57-62 pubmed
    In this study we showed a high degree of genetic homogeneity among recently (2002-2003) circulating Bovine respiratory syncytial virus (BRSV) strains in cattle population in the Czech Republic...
  63. Woolums A, Gunther R, McArthur Vaughan K, Anderson M, Omlor A, Boyle G, et al. Cytotoxic T lymphocyte activity and cytokine expression in calves vaccinated with formalin-inactivated bovine respiratory syncytial virus prior to challenge. Comp Immunol Microbiol Infect Dis. 2004;27:57-74 pubmed
    The development of effective, safe vaccines for human and bovine respiratory syncytial virus (RSV) has been problematic...
  64. Riffault S, Dubuquoy C, Castagné N, Baranowski E, Charley B, Eléouët J. Replication of bovine respiratory syncytial virus in murine cells depends on type I interferon-receptor functionality. J Gen Virol. 2006;87:2145-8 pubmed
    b>Bovine respiratory syncytial virus (BRSV) is able to counteract the alpha/beta interferon (IFN-alpha/beta)-mediated antiviral response for efficient replication in a host-specific manner...
  65. Wildman B, Perrett T, Abutarbush S, Guichon P, Pittman T, Booker C, et al. A comparison of 2 vaccination programs in feedlot calves at ultra-high risk of developing undifferentiated fever/bovine respiratory disease. Can Vet J. 2008;49:463-72 pubmed
    ..The other group (MLV4-BT1) received a vaccine containing IIBRV, type I BVDV, bovine respiratory syncytial virus, and parainfluenza-3 virus, as well as a MH bacterin-toxoid...
  66. Greenhalgh D, Griffiths M. Backward bifurcation, equilibrium and stability phenomena in a three-stage extended BRSV epidemic model. J Math Biol. 2009;59:1-36 pubmed publisher
    ..the phenomenon of backward bifurcation in epidemic modelling illustrated by an extended model for Bovine Respiratory Syncytial Virus (BRSV) amongst cattle...
  67. Werling D, Collins R, Taylor G, Howard C. Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus. J Leukoc Biol. 2002;72:297-304 pubmed
    We compared the effects of live or inactivated bovine respiratory syncytial virus (BRSV) on cytokine production by bovine monocyte-derived dendritic cells (MoDC)...
  68. Deplanche M, Lemaire M, Mirandette C, Bonnet M, Schelcher F, Meyer G. In vivo evidence for quasispecies distributions in the bovine respiratory syncytial virus genome. J Gen Virol. 2007;88:1260-5 pubmed
    We analysed the genetic evolution of bovine respiratory syncytial virus (BRSV) isolate W2-00131, from its isolation in bovine turbinate (BT) cells to its inoculation in calves...
  69. Shanthalingam S, Topliff C, Kelling C, Srikumaran S. Bighorn sheep fetal lung cell line for detection of respiratory viruses. Can J Vet Res. 2010;74:75-7 pubmed
    ..Antibodies to several respiratory viruses, including bovine parainfluenza virus 3 (BPIV-3), bovine respiratory syncytial virus (BRSV), bovine viral diarrhea virus (BVDV), and bovine herpesvirus 1 (BoHV-1), have been detected in ..
  70. Mapletoft J, Oumouna M, Townsend H, Gomis S, Babiuk L, van Drunen Littel van den Hurk S. Formulation with CpG oligodeoxynucleotides increases cellular immunity and protection induced by vaccination of calves with formalin-inactivated bovine respiratory syncytial virus. Virology. 2006;353:316-23 pubmed
    Vaccination of calves with formalin-inactivated bovine respiratory syncytial virus (FI-BRSV) induces low levels of cellular immunity that may not be protective...
  71. Stilwell G, Matos M, Carolino N, Lima M. Effect of a quadrivalent vaccine against respiratory virus on the incidence of respiratory disease in weaned beef calves. Prev Vet Med. 2008;85:151-7 pubmed publisher
    ..In conclusion, our results showed that Rispoval 4, a quadrivalent vaccine against respiratory viruses, under field conditions, reduces morbidity and mortality due to BRD in beef calves after weaning. ..
  72. Fach S, Olivier A, Gallup J, Waters T, Ackermann M, Lehmkuhl H, et al. Differential expression of cytokine transcripts in neonatal and adult ovine alveolar macrophages in response to respiratory syncytial virus or toll-like receptor ligation. Vet Immunol Immunopathol. 2010;136:55-64 pubmed publisher
    ..In the present study, we compared bovine respiratory syncytial virus (BRSV) replication and induction of cytokine responses in neonatal ovine AMvarphis to those cells ..
  73. Krzysiak M, Jabłoński A, Iwaniak W, Krajewska M, Kęsik Maliszewska J, Larska M. Seroprevalence and risk factors for selected respiratory and reproductive tract pathogen exposure in European bison (Bison bonasus) in Poland. Vet Microbiol. 2018;215:57-65 pubmed publisher
    ..2% and bovine parainfluenza type 3 (PIV-3) -34.0%, while the antibodies against bovine respiratory syncytial virus (BRSV), Toxoplasma gondii and Leptospira spp. were found in 10.4%, 10.4% and 8...
  74. Step D, Krehbiel C, Burciaga Robles L, Holland B, Fulton R, Confer A, et al. Comparison of single vaccination versus revaccination with a modified-live virus vaccine containing bovine herpesvirus-1, bovine viral diarrhea virus (types 1a and 2a), parainfluenza type 3 virus, and bovine respiratory syncytial virus in the prevent. J Am Vet Med Assoc. 2009;235:580-7 pubmed publisher
  75. Almeida R, Domingues H, Coswig L, D Arce R, de Carvalho R, Arns C. Detection of bovine respiratory syncytial virus in experimentally infected balb/c mice. Vet Res. 2004;35:189-97 pubmed
    The present study used an RT-nested-PCR and an immunohistochemistry assay to detect bovine respiratory syncytial virus in tissues from experimentally infected balb/c mice...
  76. Antonis A, van der Most R, Suezer Y, Stockhofe Zurwieden N, Daus F, Sutter G, et al. Vaccination with recombinant modified vaccinia virus Ankara expressing bovine respiratory syncytial virus (bRSV) proteins protects calves against RSV challenge. Vaccine. 2007;25:4818-27 pubmed
    ..Immunized animals showed reduced pulmonary virus loads, and no eosinophilic infiltration or enhanced respiratory distress. In conclusion, candidate rMVA/bRSV vaccines induced protective and safe immune responses in calves. ..
  77. Harmeyer S, Murray J, Imrie C, Wiseman A, Salt J. Efficacy of a live bovine respiratory syncytial virus vaccine in seropositive calves. Vet Rec. 2006;159:456-7 pubmed
  78. Riffault S, Meyer G, Deplanche M, Dubuquoy C, Durand G, Soulestin M, et al. A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus. Vaccine. 2010;28:3722-34 pubmed publisher
    ..Vaccinated calves had lower viral loads than the non-vaccinated control calves. Thus N(SRS) vaccination in calves provided cross-protective immunity against BRSV infection without adverse inflammatory reaction. ..
  79. Zimmer G, Conzelmann K, Herrler G. Cleavage at the furin consensus sequence RAR/KR(109) and presence of the intervening peptide of the respiratory syncytial virus fusion protein are dispensable for virus replication in cell culture. J Virol. 2002;76:9218-24 pubmed
    ..A deletion mutant containing FCS-1 but lacking FCS-2 and most of pep27 replicated in cell culture as efficiently as the parental virus, indicating that this domain of the F protein is not essential for virus maturation and infectivity. ..
  80. Keles I, Sharma A, Woldehiwet Z, Murray R. The effects of bovine respiratory syncytial on normal ovine lymphocyte responses to mitogens or antigens in vitro. Comp Immunol Microbiol Infect Dis. 1999;22:1-13 pubmed
    ..cells (MNC) obtained from normal uninfected lambs were used to study the possible effects of bovine respiratory syncytial virus (BRSV) on lymphocyte responses to the mitogens, phytohaemagglutinin (PHA), concanavalin A (Con A) ..
  81. Keil G. Fusion of the green fluorescent protein to amino acids 1 to 71 of bovine respiratory syncytial virus glycoprotein G directs the hybrid polypeptide as a class II membrane protein into the envelope of recombinant bovine herpesvirus-1. J Gen Virol. 2000;81:1051-5 pubmed
    It was recently shown that the class II membrane glycoprotein G of bovine respiratory syncytial virus (BRSV) is integrated into the envelope of recombinant bovine herpesvirus-1 (BHV-1) virions in the correct orientation...
  82. Valarcher J, Furze J, Wyld S, Cook R, Zimmer G, Herrler G, et al. Bovine respiratory syncytial virus lacking the virokinin or with a mutation in furin cleavage site RA(R/K)R109 induces less pulmonary inflammation without impeding the induction of protective immunity in calves. J Gen Virol. 2006;87:1659-67 pubmed
    ..Nevertheless, resistance to BRSV challenge induced by the mutant and WT viruses was similar, suggesting that neither pep27 nor FCS-2 plays a major role in the induction of protective immunity. ..
  83. Kalina W, Anderson M, Gershwin L. Alternaria aerosol during a bovine respiratory syncytial virus infection alters the severity of subsequent re-infection and enhances IgE production. Comp Immunol Microbiol Infect Dis. 2006;29:138-56 pubmed
    ..Alternaria aerosols during primary and secondary BRSV infections decreased disease in secondary infections; however, BRSV infection enhanced Th2 responses against inhaled Alternaria. ..
  84. Krempl C, Lamirande E, Collins P. Complete sequence of the RNA genome of pneumonia virus of mice (PVM). Virus Genes. 2005;30:237-49 pubmed
    ..The various genes of PVM shared 29-62% nucleotide sequence identity and 10-60% amino acid sequence identity with human or bovine respiratory syncytial virus (HRSV and BRSV), its closest relatives.
  85. Deem S, Noss A, Villarroel R, Uhart M, Karesh W. Disease survey of free-ranging grey brocket deer (Mazama gouazoubira) in the Gran Chaco, Bolivia. J Wildl Dis. 2004;40:92-8 pubmed
    ..Serologic tests were positive for antibodies against bovine respiratory syncytial virus and four Leptospira interrogans serovars, with questionable results for epizootic hemorrhagic ..
  86. Antonis A, de Jong M, van der Poel W, van der Most R, Stockhofe Zurwieden N, Kimman T, et al. Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence. J Gen Virol. 2010;91:2497-506 pubmed publisher
    ..The capacity to produce pro-inflammatory TNF-α appeared to increase with age, and may explain the age-dependent differences in RSV pathogenesis. ..
  87. Schrijver R, Langedijk J, Middel W, Kramps J, Rijsewijk F, van Oirschot J. A bovine respiratory syncytial virus strain with mutations in subgroup-specific antigenic domains of the G protein induces partial heterologous protection in cattle. Vet Microbiol. 1998;63:159-75 pubmed
    b>Bovine respiratory syncytial virus (BRSV) strains are tentatively divided in subgroups A, AB and B, based on antigenic differences of the G protein...
  88. Gaddum R, Cook R, Furze J, Ellis S, Taylor G. Recognition of bovine respiratory syncytial virus proteins by bovine CD8+ T lymphocytes. Immunology. 2003;108:220-9 pubmed
    CD8+ T lymphocytes play a major role in the clearance of bovine respiratory syncytial virus (BRSV), an important respiratory pathogen of young calves that shares many of the epidemiological and pathological features of human respiratory ..
  89. Ellis J, West K, Konoby C, Leard T, Gallo G, Conlon J, et al. Efficacy of an inactivated respiratory syncytial virus vaccine in calves. J Am Vet Med Assoc. 2001;218:1973-80 pubmed
    To determine whether an inactivated bovine respiratory syncytial virus (BRSV) vaccine would protect calves from infection with virulent BRSV. Randomized controlled trial. 27 nine-week-old calves seronegative for BRSV exposure...