metapneumovirus

Summary

Summary: A genus of the subfamily PNEUMOVIRINAE, containing two members: Turkey rhinotracheitis virus and a human Metapneumovirus. Virions lack HEMAGGLUTININ and NEURAMINIDASE.

Top Publications

  1. Caracciolo S, Minini C, Colombrita D, Rossi D, Miglietti N, Vettore E, et al. Human metapneumovirus infection in young children hospitalized with acute respiratory tract disease: virologic and clinical features. Pediatr Infect Dis J. 2008;27:406-12 pubmed publisher
    Human metapneumovirus (hMPV) is an emerging virus associated with acute respiratory tract infections (ARIs) in young children. To evaluate virologic and clinical features of hMPV infection during 2 consecutive winter-spring seasons...
  2. Shirogane Y, Takeda M, Iwasaki M, Ishiguro N, Takeuchi H, Nakatsu Y, et al. Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2. J Virol. 2008;82:8942-6 pubmed publisher
    Human metapneumovirus (HMPV) is a major causative agent of severe bronchiolitis and pneumonia. Its fusion (F) protein must be cleaved by host proteases to cause membrane fusion, a critical step for virus infection...
  3. Mendes G, Soares A, Martins F, Albuquerque M, Costa S, Yoneshigue Valentin Y, et al. Antiviral activity of the green marine alga Ulva fasciata on the replication of human metapneumovirus. Rev Inst Med Trop Sao Paulo. 2010;52:3-10 pubmed
    ..collected from Rasa beach and Forno beach, Búzios, Rio de Janeiro, Brazil on the replication of human metapneumovirus (HMPV)...
  4. Guerrero Plata A, Kolli D, Hong C, Casola A, Garofalo R. Subversion of pulmonary dendritic cell function by paramyxovirus infections. J Immunol. 2009;182:3072-83 pubmed publisher
    Lower respiratory tract infections caused by the paramyxoviruses human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are characterized by short-lasting virus-specific immunity and often long-term airway morbidity, both of ..
  5. Shahda S, Carlos W, Kiel P, Khan B, Hage C. The human metapneumovirus: a case series and review of the literature. Transpl Infect Dis. 2011;13:324-8 pubmed publisher
    Human metapneumovirus (hMPV) is an emerging human pulmonary pathogen that is genetically related to respiratory syncytial virus. It has been increasingly associated with respiratory illnesses over the last few decades...
  6. Arabpour M, Samarbafzadeh A, Makvandi M, Shamsizadeh A, Percivalle E, Englud J, et al. The highest prevalence of human metapneumovirus in Ahwaz children accompanied by acute respiratory infections. Indian J Med Microbiol. 2008;26:123-6 pubmed
    The newly described human metapneumovirus (hMPV) has been recently discovered as an etiological agent of acute respiratory infections (ARTI) in infants and children...
  7. Papenburg J, Carbonneau J, Isabel S, Bergeron M, Williams J, De Serres G, et al. Genetic diversity and molecular evolution of the major human metapneumovirus surface glycoproteins over a decade. J Clin Virol. 2013;58:541-7 pubmed publisher
    Human metapneumovirus (HMPV) is a recently discovered paramyxovirus that is a major cause of respiratory infections worldwide...
  8. Xiao N, Xie Z, Zhang B, Yuan X, Song J, Gao H, et al. Prevalence and clinical and molecular characterization of human metapneumovirus in children with acute respiratory infection in China. Pediatr Infect Dis J. 2010;29:131-4 pubmed
    Human metapneumovirus (HMPV), a newly discovered paramyxovirus, has been associated with acute respiratory tract infections (ARTIs). However, the prevalence and molecular characteristics of HMPV in China are still unclear.
  9. Widmer K, Zhu Y, Williams J, Griffin M, Edwards K, Talbot H. Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. J Infect Dis. 2012;206:56-62 pubmed publisher
    We performed a prospective study to determine the disease burden of respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) in older adults in comparison with influenza virus.

More Information

Publications104 found, 100 shown here

  1. Legrand L, Vabret A, Dina J, Petitjean Lecherbonnier J, Stéphanie G, Cuvillon D, et al. Epidemiological and phylogenic study of human metapneumovirus infections during three consecutive outbreaks in Normandy, France. J Med Virol. 2011;83:517-24 pubmed publisher
    Human metapneumovirus (hMPV) is responsible for respiratory tract disease, particularly in the young and elderly population...
  2. Nascimento Carvalho C, Cardoso M, Ruuskanen O, Lappalainen M. Sole infection by human metapneumovirus among children with radiographically diagnosed community-acquired pneumonia in a tropical region. Influenza Other Respir Viruses. 2011;5:285-7 pubmed publisher
    Limited information is available on the role of human metapneumovirus (HMPV) as the unique pathogen among children hospitalized for community-acquired pneumonia (CAP) in a tropical region...
  3. Lupini C, Cecchinato M, Scagliarini A, Graziani R, Catelli E. In vitro antiviral activity of chestnut and quebracho woods extracts against avian reovirus and metapneumovirus. Res Vet Sci. 2009;87:482-7 pubmed publisher
    ..the animal feed industry, were tested for in vitro antiviral activity against avian reovirus (ARV) and avian metapneumovirus (AMPV). The MTT assay was used to evaluate the 50% cytotoxic compounds concentration (CC(50)) on Vero cells...
  4. Campbell A, Chien J, Kuypers J, Englund J, Wald A, Guthrie K, et al. Respiratory virus pneumonia after hematopoietic cell transplantation (HCT): associations between viral load in bronchoalveolar lavage samples, viral RNA detection in serum samples, and clinical outcomes of HCT. J Infect Dis. 2010;201:1404-13 pubmed publisher
    ..identified HCT recipients with respiratory syncytial virus (RSV), parainfluenza virus, influenza virus, metapneumovirus (MPV), and coronavirus (CoV) detected in bronchoalveolar lavage (BAL) samples, and we tested stored BAL and/..
  5. Chang A, Masante C, Buchholz U, Dutch R. Human metapneumovirus (HMPV) binding and infection are mediated by interactions between the HMPV fusion protein and heparan sulfate. J Virol. 2012;86:3230-43 pubmed publisher
    Human metapneumovirus (HMPV) is a major worldwide respiratory pathogen that causes acute upper and lower respiratory tract disease. The mechanism by which this virus recognizes and gains access to its target cell is still largely unknown...
  6. Yang C, Wang C, Tollefson S, Piyaratna R, Lintao L, Chu M, et al. Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years. Virol J. 2009;6:138 pubmed publisher
    Human metapneumovirus (HMPV) is an important cause of acute respiratory illness in children. We examined the diversity and molecular evolution of HMPV using 85 full-length F (fusion) gene sequences collected over a 20-year period. ..
  7. Le Nouen C, Hillyer P, Winter C, McCarty T, Rabin R, Collins P, et al. Low CCR7-mediated migration of human monocyte derived dendritic cells in response to human respiratory syncytial virus and human metapneumovirus. PLoS Pathog. 2011;7:e1002105 pubmed publisher
    Human respiratory syncytial virus (HRSV) and, to a lesser extent, human metapneumovirus (HMPV) and human parainfluenza virus type 3 (HPIV3), can re-infect symptomatically throughout life without significant antigenic change, suggestive ..
  8. Mok H, Tollefson S, Podsiad A, Shepherd B, Polosukhin V, Johnston R, et al. An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton rats. J Virol. 2008;82:11410-8 pubmed publisher
    Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that causes upper and lower respiratory tract infections in infants, the elderly, and immunocompromised individuals worldwide...
  9. Ludewick H, Aerts L, Hamelin M, Boivin G. Long-term impairment of Streptococcus pneumoniae lung clearance is observed after initial infection with influenza A virus but not human metapneumovirus in mice. J Gen Virol. 2011;92:1662-5 pubmed publisher
    Human metapneumovirus (hMPV) is a paramyxovirus responsible for respiratory tract infections in humans...
  10. Zhang C, Du L, Zhang Z, Qin X, Yang X, Liu P, et al. Detection and genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in Southwest China. J Clin Microbiol. 2012;50:2714-9 pubmed publisher
    Human metapneumovirus (hMPV) is the main pathogen causing respiratory tract infection in susceptible populations, particularly in children and the elderly...
  11. Cox R, Livesay S, Johnson M, Ohi M, Williams J. The human metapneumovirus fusion protein mediates entry via an interaction with RGD-binding integrins. J Virol. 2012;86:12148-60 pubmed publisher
    ..In contrast, human metapneumovirus (HMPV) expressing only the F protein is replication competent, suggesting a primary role for HMPV F in ..
  12. Aerts L, Hamelin M, Rhéaume C, Lavigne S, Couture C, Kim W, et al. Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model. PLoS ONE. 2013;8:e72529 pubmed publisher
    Human metapneumovirus (hMPV) infection causes acute respiratory tract infections (RTI) which can result in hospitalization of both children and adults. To date, no antiviral or vaccine is available for this common viral infection...
  13. Banerjee S, Sullender W, Choudekar A, John C, Tyagi V, Fowler K, et al. Detection and genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in India. J Med Virol. 2011;83:1799-810 pubmed publisher
    Human metapneumovirus (hMPV) causes acute respiratory infections in children and adults. It is classified into two major genetic lineages and each lineage into two sublineages...
  14. Matsuzaki Y, Itagaki T, Abiko C, Aoki Y, Suto A, Mizuta K. Clinical impact of human metapneumovirus genotypes and genotype-specific seroprevalence in Yamagata, Japan. J Med Virol. 2008;80:1084-9 pubmed publisher
    The clinical impact of human metapneumovirus (hMPV) genotypes and the relation between the hMPV genotype in circulation and genotype-specific seroprevalence are yet to be clarified...
  15. Kaur T, Singh J, Tong S, Humphrey C, Clevenger D, Tan W, et al. Descriptive epidemiology of fatal respiratory outbreaks and detection of a human-related metapneumovirus in wild chimpanzees (Pan troglodytes) at Mahale Mountains National Park, Western Tanzania. Am J Primatol. 2008;70:755-65 pubmed publisher
    ..Analysis of fecal samples from 2005 suggests the presence of paramyxovirus, and in 2006 a human-related metapneumovirus was detected and identified in an affected chimpanzee whose infant died during the outbreak...
  16. Darniot M, Pitoiset C, Petrella T, Aho S, Pothier P, Manoha C. Age-associated aggravation of clinical disease after primary metapneumovirus infection of BALB/c mice. J Virol. 2009;83:3323-32 pubmed publisher
    Human metapneumovirus (hMPV) is associated with respiratory tract infections among children and adults...
  17. Tollefson S, Cox R, Williams J. Studies of culture conditions and environmental stability of human metapneumovirus. Virus Res. 2010;151:54-9 pubmed publisher
    Human metapneumovirus (HMPV) is a paramyxovirus that is a leading cause of acute respiratory disease...
  18. Christensen A, Nordbø S, Krokstad S, Rognlien A, Døllner H. Human bocavirus commonly involved in multiple viral airway infections. J Clin Virol. 2008;41:34-7 pubmed
    ..Human bocavirus (HBoV) was recently discovered in children with acute respiratory tract infections. We have included a PCR for HBoV in a study on airway infections in children...
  19. Ulbrandt N, Ji H, Patel N, Barnes A, Wilson S, Kiener P, et al. Identification of antibody neutralization epitopes on the fusion protein of human metapneumovirus. J Gen Virol. 2008;89:3113-8 pubmed publisher
    Human metapneumovirus (hMPV) is genetically related to respiratory syncytial virus (RSV); both cause respiratory tract illnesses ranging from a mild cough to bronchiolitis and pneumonia...
  20. Zhang S, Tellier R, Zafar R, Cheung R, Adachi D, Richardson S. Comparison of human metapneumovirus infection with respiratory syncytial virus infection in children. Pediatr Infect Dis J. 2009;28:1022-4 pubmed publisher
    We aimed to validate a direct immunofluorescence assay (DFA) for the detection of human metapneumovirus (hMPV) from nasal swabs and to determine the incidence and clinical features of this viral infection in a pediatric population...
  21. Falsey A, Hennessey P, Formica M, Criddle M, Biear J, Walsh E. Humoral immunity to human metapneumovirus infection in adults. Vaccine. 2010;28:1477-80 pubmed publisher
    Human metapneumovirus (hMPV) is a significant cause of respiratory illness in children and adults. Presently, there are no human data regarding the role of antibody for protection against hMPV illness...
  22. Hermos C, Vargas S, McAdam A. Human metapneumovirus. Clin Lab Med. 2010;30:131-48 pubmed publisher
    ..Most RTI are viral. Human metapneumovirus (hMPV) was discovered in 2001 in routine viral cultures of respiratory specimens from children with RTI and ..
  23. Don M, Korppi M, Valent F, Vainionpaa R, Canciani M. Human metapneumovirus pneumonia in children: results of an Italian study and mini-review. Scand J Infect Dis. 2008;40:821-6 pubmed publisher
    Human metapneumovirus (hMPV) is a newly identified paramyxovirus causing lower respiratory tract infections (LRTI). Current knowledge on hMPV is mainly based on retrospective studies performed in stored respiratory and serum samples...
  24. Weinberg A, Lyu D, Li S, Marquesen J, Zamora M. Incidence and morbidity of human metapneumovirus and other community-acquired respiratory viruses in lung transplant recipients. Transpl Infect Dis. 2010;12:330-5 pubmed publisher
    To determine the role of human metapneumovirus (HMPV) in respiratory tract infections (RTIs) of lung transplant recipients, 60 patients were prospectively enrolled in this study spanning from September 2005 to November 2007...
  25. Li I, To K, Tang B, Chan K, Hui C, Cheng V, et al. Human metapneumovirus infection in an immunocompetent adult presenting as mononucleosis-like illness. J Infect. 2008;56:389-92 pubmed publisher
    ..Polymerase chain reaction (PCR) and viral culture of the nasopharyngeal swab showed human metapneumovirus (hMPV). There was a >/=4-fold rise in IgG against hMPV...
  26. Velayudhan B, Yu Q, Estevez C, Nagaraja K, Halvorson D. Glycoprotein gene truncation in avian metapneumovirus subtype C isolates from the United States. Virus Genes. 2008;37:266-72 pubmed publisher
    The length of the published glycoprotein (G) gene sequences of avian metapneumovirus subtype-C (aMPV-C) isolated from domestic turkeys and wild birds in the United States (1996-2003) remains controversial...
  27. Wang H, Huang S, Wang S, Tsai H, Kiang D, Wang S, et al. Co-circulating genetically divergent A2 human metapneumovirus strains among children in southern Taiwan. Arch Virol. 2008;153:2207-13 pubmed publisher
    An outbreak of human metapneumovirus (hMPV) among children in southern Taiwan in 2004 prompted the investigation of the molecular epidemiology of hMPV from September 2003 to August 2005...
  28. Spaeder M, Custer J, Bembea M, Aganga D, Song X, Scafidi S. A multicenter outcomes analysis of children with severe viral respiratory infection due to human metapneumovirus. Pediatr Crit Care Med. 2013;14:268-72 pubmed publisher
    To investigate the impact of human metapneumovirus on morbidity and mortality outcomes in children with severe viral respiratory infection. Retrospective cohort study...
  29. Lüsebrink J, Wiese C, Thiel A, Tillmann R, Ditt V, Muller A, et al. High seroprevalence of neutralizing capacity against human metapneumovirus in all age groups studied in Bonn, Germany. Clin Vaccine Immunol. 2010;17:481-4 pubmed publisher
    Human metapneumovirus (hMPV) infections occur frequently despite high rates of perpetual seroprevalence for all age groups...
  30. Lu G, Gonzalez R, Guo L, Wu C, Wu J, Vernet G, et al. Large-scale seroprevalence analysis of human metapneumovirus and human respiratory syncytial virus infections in Beijing, China. Virol J. 2011;8:62 pubmed publisher
    Human metapneumovirus (hMPV), a recently identified virus, causes acute respiratory tract infections (ARTIs) in infants and children. However, studies on the seroepidemeology of hMPV are very limited in China...
  31. Egli A, Bucher C, Dumoulin A, Stern M, Buser A, Bubendorf L, et al. Human metapneumovirus infection after allogeneic hematopoietic stem cell transplantation. Infection. 2012;40:677-84 pubmed publisher
    The clinical characteristics of human metapneumovirus (hMPV)-associated lower respiratory tract infection (LRTI) after allogeneic hematopoietic stem cell transplantation (HSCT) is not well described...
  32. Souza J, Watanabe A, Carraro E, Granato C, Bellei N. Severe metapneumovirus infections among immunocompetent and immunocompromised patients admitted to hospital with respiratory infection. J Med Virol. 2013;85:530-6 pubmed publisher
    Human metapneumovirus (hMPV) is considered an important cause of acute respiratory infections...
  33. Johnstone J, Majumdar S, Fox J, Marrie T. Human metapneumovirus pneumonia in adults: results of a prospective study. Clin Infect Dis. 2008;46:571-4 pubmed publisher
    We prospectively collected clinical, laboratory, and radiographic data regarding community-acquired human metapneumovirus (hMPV) infection in consecutive adults hospitalized with pneumonia...
  34. Cseke G, Maginnis M, Cox R, Tollefson S, Podsiad A, Wright D, et al. Integrin alphavbeta1 promotes infection by human metapneumovirus. Proc Natl Acad Sci U S A. 2009;106:1566-71 pubmed publisher
    Human metapneumovirus (hMPV) is a recently described paramyxovirus that causes lower respiratory infections in children and adults worldwide. The hMPV fusion (F) protein is a membrane-anchored glycoprotein and major protective antigen...
  35. Uhlenhaut C, Cohen J, FEDORKO D, Nanda S, Krause P. Use of a universal virus detection assay to identify human metapneumovirus in a hematopoietic stem cell transplant recipient with pneumonia of unknown origin. J Clin Virol. 2009;44:337-9 pubmed publisher
    ..Generic PCR products were cloned and sequenced. The novel universal virus assay detected human metapneumovirus in the clinical sample...
  36. Kitagawa Y, Zhou M, Yamaguchi M, Komatsu T, Takeuchi K, Itoh M, et al. Human metapneumovirus M2-2 protein inhibits viral transcription and replication. Microbes Infect. 2010;12:135-45 pubmed publisher
    M2-2 protein of human metapneumovirus (HMPV) is encoded by one of two overlapping open reading frames within M2 mRNA. The precise function of HMPV M2-2 protein remains unknown...
  37. Williams J, Edwards K, Weinberg G, Griffin M, Hall C, Zhu Y, et al. Population-based incidence of human metapneumovirus infection among hospitalized children. J Infect Dis. 2010;201:1890-8 pubmed publisher
    Human metapneumovirus (HMPV) is a leading cause of acute respiratory illness (ARI) in children. Population-based incidence rates and comprehensive clinical characterizations of disease have not been established...
  38. Okamoto M, Sugawara K, Takashita E, Muraki Y, Hongo S, Nishimura H, et al. Longitudinal course of human metapneumovirus antibody titers and reinfection in healthy adults. J Med Virol. 2010;82:2092-6 pubmed publisher
    The purpose of this study was to evaluate the frequency of human metapneumovirus (hMPV) infection in adults and to determine the association between the levels of serum antibody titers and the susceptibility to reinfection...
  39. Ditt V, Lüsebrink J, Tillmann R, Schildgen V, Schildgen O. Respiratory infections by HMPV and RSV are clinically indistinguishable but induce different host response in aged individuals. PLoS ONE. 2011;6:e16314 pubmed publisher
    Human metapneumovirus and respiratory syncytial virus can cause severe respiratory diseases, especially in infants, young children, and the elderly...
  40. Agrawal A, Roy T, Ghosh S, Chawla Sarkar M. Genetic variability of attachment (G) and Fusion (F) protein genes of human metapneumovirus strains circulating during 2006-2009 in Kolkata, Eastern India. Virol J. 2011;8:67 pubmed publisher
    Human metapneumovirus (hMPV) is associated with the acute respiratory tract infection (ARTI) in all the age groups...
  41. Gaunt E, Jansen R, Poovorawan Y, Templeton K, Toms G, Simmonds P. Molecular epidemiology and evolution of human respiratory syncytial virus and human metapneumovirus. PLoS ONE. 2011;6:e17427 pubmed publisher
    Human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV) are ubiquitous respiratory pathogens of the Pneumovirinae subfamily of the Paramyxoviridae...
  42. Palacios G, Lowenstine L, Cranfield M, Gilardi K, Spelman L, Lukasik Braum M, et al. Human metapneumovirus infection in wild mountain gorillas, Rwanda. Emerg Infect Dis. 2011;17:711-3 pubmed publisher
    ..Human-to-gorilla transmission may explain human metapneumovirus in 2 wild mountain gorillas that died during a respiratory disease outbreak in Rwanda in 2009...
  43. Schildgen V, van den Hoogen B, Fouchier R, Tripp R, Alvarez R, Manoha C, et al. Human Metapneumovirus: lessons learned over the first decade. Clin Microbiol Rev. 2011;24:734-54 pubmed publisher
    It has been 10 years since human metapneumovirus (HMPV) was identified as a causative agent of respiratory illness in humans. Since then, numerous studies have contributed to a substantial body of knowledge on many aspects of HMPV...
  44. Alonso W, Laranjeira B, Pereira S, Florencio C, Moreno E, Miller M, et al. Comparative dynamics, morbidity and mortality burden of pediatric viral respiratory infections in an equatorial city. Pediatr Infect Dis J. 2012;31:e9-14 pubmed publisher
    ..analyzed the relative burden of influenza, parainfluenza, respiratory syncytial virus (RSV), adenovirus, and metapneumovirus, their seasonality, and their association with climatic and demographic factors, ARI diagnosis, and pediatric ..
  45. Regev L, Meningher T, Hindiyeh M, Mendelson E, Mandelboim M. Increase human metapneumovirus mediated morbidity following pandemic influenza infection. PLoS ONE. 2012;7:e34750 pubmed publisher
    Human metapneumovirus (hMPV) is a recently discovered respiratory pathogen, infecting mainly young children. The infected patients suffer from influenza like symptoms (ILS). In Israel the virus is mainly circulating in February to March...
  46. Dou Y, Zhao Y, Zhang Z, Mao H, Tu W, Zhao X. Respiratory syncytial virus infection induces higher Toll-like receptor-3 expression and TNF-α production than human metapneumovirus infection. PLoS ONE. 2013;8:e73488 pubmed publisher
    Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are common causes of respiratory infections in children...
  47. Lee N, Chan P, Yu I, Tsoi K, Lui G, Sung J, et al. Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong. J Clin Virol. 2007;40:333-7 pubmed
    The clinico-epidemiological significance of human metapneumovirus (hMPV) detected during the SARS outbreak is unknown. To characterize a nosocomial hMPV outbreak during the 2003 SARS epidemic...
  48. Cha R, Khatri M, Sharma J. B-cell infiltration in the respiratory mucosa of turkeys exposed to subtype C avian metapneumovirus. Avian Dis. 2007;51:764-70 pubmed
    Turkeys exposed to avian metapneumovirus (aMPV) subtype C showed extensive lymphoid cell infiltrations in the nasal turbinates of the upper respiratory tract...
  49. Oliveira R, Machado A, Tateno A, Boas L, Pannuti C, Machado C. Frequency of human metapneumovirus infection in hematopoietic SCT recipients during 3 consecutive years. Bone Marrow Transplant. 2008;42:265-9 pubmed publisher
    Respiratory viruses can cause significant morbidity in immunocompromised hosts. Human metapneumovirus (hMPV) has been increasingly associated with lower respiratory tract infection in hematopoietic SCT (HSCT) recipients, with mortality ..
  50. El Sayed Zaki M, Raafat D, El Metaal A, Ismail M. Study of human metapneumovirus-associated lower respiratory tract infections in Egyptian adults. Microbiol Immunol. 2009;53:603-8 pubmed publisher
    ..The pathogens isolated were Streptococcus pneumoniae 46.6%, Staphylococci aureus 35.2%, and human metapneumovirus 13.6%. Influenza virus and rhinovirus were each isolated from 4.5% of patients...
  51. van Diepen A, Brand H, Sama I, Lambooy L, van den Heuvel L, van der Well L, et al. Quantitative proteome profiling of respiratory virus-infected lung epithelial cells. J Proteomics. 2010;73:1680-93 pubmed publisher
    ..Influenza virus, respiratory syncytial virus (RSV), parainfluenza (PIV) and human metapneumovirus (hMPV) are major causes of respiratory illness in humans...
  52. Kolli D, Bao X, Liu T, Hong C, Wang T, Garofalo R, et al. Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells. J Immunol. 2011;187:47-54 pubmed publisher
    Human metapneumovirus (hMPV) is a major cause of upper and lower respiratory infections in children and adults...
  53. Petraityt Burneikien R, Nalivaiko K, Lasickien R, Firantien R, Emu yt R, Sasnauskas K, et al. Generation of recombinant metapneumovirus nucleocapsid protein as nucleocapsid-like particles and development of virus-specific monoclonal antibodies. Virus Res. 2011;161:131-9 pubmed publisher
    Human metapneumovirus (hMPV) is a member of the Pneumovirinea subfamily within the Paramyxoviridea family. Since its discovery in 2001, hMPV has been isolated in several continents, which suggests its prevalence worldwide...
  54. Clubbe J, Naylor C. Avian metapneumovirus M2:2 protein inhibits replication in Vero cells: modification facilitates live vaccine development. Vaccine. 2011;29:9493-8 pubmed publisher
    Throughout the world, avian metapneumovirus (AMPV) infection of subtype A is principally controlled by two live vaccines both derived from UK field strain #8544...
  55. Apostoli P, Zicari S, Lo Presti A, Ciccozzi M, Ciotti M, Caruso A, et al. Human metapneumovirus-associated hospital admissions over five consecutive epidemic seasons: evidence for alternating circulation of different genotypes. J Med Virol. 2012;84:511-6 pubmed publisher
    Human metapneumovirus (hMPV) is a pathogen of the respiratory tract with a worldwide distribution...
  56. Li J, Ren L, Guo L, Xiang Z, Paranhos Baccala G, Vernet G, et al. Evolutionary dynamics analysis of human metapneumovirus subtype A2: genetic evidence for its dominant epidemic. PLoS ONE. 2012;7:e34544 pubmed publisher
    Human metapneumovirus (hMPV) is a respiratory viral pathogen in children worldwide. hMPV is divided into four subtypes: hMPV_A1, hMPV_A2, hMPV_B1, and hMPV_B2...
  57. Papenburg J, Hamelin M, Ouhoummane N, Carbonneau J, Ouakki M, Raymond F, et al. Comparison of risk factors for human metapneumovirus and respiratory syncytial virus disease severity in young children. J Infect Dis. 2012;206:178-89 pubmed publisher
    Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are leading pediatric pathogens. However, risk factors for severe hMPV disease remain unknown...
  58. Erickson J, Gilchuk P, Hastings A, Tollefson S, Johnson M, Downing M, et al. Viral acute lower respiratory infections impair CD8+ T cells through PD-1. J Clin Invest. 2012;122:2967-82 pubmed publisher
    ..PD-1-mediated TCD8 impairment occurred acutely in mice following infection with human metapneumovirus or influenza virus...
  59. Adamson P, Thammawat S, Muchondo G, Sadlon T, Gordon D. Diversity in glycosaminoglycan binding amongst hMPV G protein lineages. Viruses. 2012;4:3785-803 pubmed publisher
    ..Analysis of both native and recombinant F protein confirmed that F protein binds heparin, supporting this conclusion. ..
  60. Wei Y, Zhang Y, Cai H, Mirza A, Iorio R, Peeples M, et al. Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis. J Virol. 2014;88:4338-52 pubmed publisher
    Human metapneumovirus (hMPV) is a relatively recently identified paramyxovirus that causes acute upper and lower respiratory tract infection...
  61. Ling R, Sinkovic S, Toquin D, Guionie O, Eterradossi N, Easton A. Deletion of the SH gene from avian metapneumovirus has a greater impact on virus production and immunogenicity in turkeys than deletion of the G gene or M2-2 open reading frame. J Gen Virol. 2008;89:525-33 pubmed publisher
    ..There was no correlation between virus replication and antibody response, suggesting that replication sites other than the trachea may be important for induction of antibody responses. ..
  62. Hamelin M, Couture C, Sackett M, Kiener P, Suzich J, Ulbrandt N, et al. The prophylactic administration of a monoclonal antibody against human metapneumovirus attenuates viral disease and airways hyperresponsiveness in mice. Antivir Ther. 2008;13:39-46 pubmed
    Human metapneumovirus (hMPV) is one of the most frequent causes of respiratory tract infections in children...
  63. Abed Y, Boivin G. Human metapneumovirus infection in immunocompromised child. Emerg Infect Dis. 2008;14:854-6 pubmed publisher
  64. Deffrasnes C, Cavanagh M, Goyette N, Cui K, Ge Q, Seth S, et al. Inhibition of human metapneumovirus replication by small interfering RNA. Antivir Ther. 2008;13:821-32 pubmed
    Human metapneumovirus (hMPV) is a major respiratory viral pathogen in young children, elderly individuals and immunocompromised patients...
  65. Derdowski A, Peters T, Glover N, Qian R, Utley T, Burnett A, et al. Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation. J Gen Virol. 2008;89:2698-708 pubmed publisher
    Human metapneumovirus (HMPV) is a recently discovered paramyxovirus of the subfamily Pneumovirinae, which also includes avian pneumovirus and human respiratory syncytial virus (HRSV)...
  66. Gaunt E, McWilliam Leitch E, Templeton K, Simmonds P. Incidence, molecular epidemiology and clinical presentations of human metapneumovirus; assessment of its importance as a diagnostic screening target. J Clin Virol. 2009;46:318-24 pubmed publisher
    Human metapneumovirus (HMPV) is a recently discovered human paramyxovirus associated with a spectrum of respiratory symptoms from the common cold to pneumonia and bronchiolitis.
  67. Bruno R, Marsico S, Minini C, Apostoli P, Fiorentini S, Caruso A. Human metapneumovirus infection in a cohort of young asymptomatic subjects. New Microbiol. 2009;32:297-301 pubmed
    Human metapneumovirus (HMPV) is a recently described cause of respiratory infection. The purpose of this study was to to further the available information on the circulation of HMPV among young asymptomatic subjects...
  68. Jokela P, Piiparinen H, Luiro K, Lappalainen M. Detection of human metapneumovirus and respiratory syncytial virus by duplex real-time RT-PCR assay in comparison with direct fluorescent assay. Clin Microbiol Infect. 2010;16:1568-73 pubmed publisher
    Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are important respiratory pathogens of small children and adults...
  69. Papenburg J, Boivin G. The distinguishing features of human metapneumovirus and respiratory syncytial virus. Rev Med Virol. 2010;20:245-60 pubmed publisher
    Acute respiratory tract infections (RTIs) are a leading cause of morbidity and mortality worldwide. Human Metapneumovirus (hMPV) is a member of the Metapneumovirus genus within the Pneumovirinae subfamily of the Paramyxoviridae family...
  70. Le Nouen C, Hillyer P, Munir S, Winter C, McCarty T, Bukreyev A, et al. Effects of human respiratory syncytial virus, metapneumovirus, parainfluenza virus 3 and influenza virus on CD4+ T cell activation by dendritic cells. PLoS ONE. 2010;5:e15017 pubmed publisher
    Human respiratory syncytial virus (HRSV), and to a lesser extent human metapneumovirus (HMPV) and human parainfluenza virus type 3 (HPIV3), re-infect symptomatically throughout life without antigenic change, suggestive of incomplete ..
  71. Weng Y, Lu W, Harmon A, Xiang X, Deng Q, Song M, et al. The cellular endosomal sorting complex required for transport pathway is not involved in avian metapneumovirus budding in a virus-like-particle expression system. J Gen Virol. 2011;92:1205-13 pubmed publisher
    Avian metapneumovirus (AMPV) is a paramyxovirus that principally causes respiratory disease and egg production drops in turkeys and chickens...
  72. Rock M, McKinney B, Yoder S, Prudom C, Wright D, Crowe J. Identification of potential human respiratory syncytial virus and metapneumovirus T cell epitopes using computational prediction and MHC binding assays. J Immunol Methods. 2011;374:13-7 pubmed publisher
    Human respiratory syncytial virus (RSV) and human metapneumovirus (MPV) are two of the most common causes of serious viral lower respiratory tract illness in humans...
  73. Garcia J, Sovero M, Kochel T, Laguna Torres V, Gamero M, Gomez J, et al. Human metapneumovirus strains circulating in Latin America. Arch Virol. 2012;157:563-8 pubmed publisher
    The human metapneumovirus (HMPV) is responsible for acute respiratory tract infections in young children, elderly patients, and immunocompromised hosts...
  74. Wen X, Krause J, Leser G, Cox R, Lamb R, Williams J, et al. Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site. Nat Struct Mol Biol. 2012;19:461-3 pubmed publisher
    Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation...
  75. Espinal D, Hurtado I, Arango A, Garcia J, Laguna Torres V, Jaramillo S. [Human metapneumovirus in children: first cases in Colombia]. Biomedica. 2012;32:174-8 pubmed publisher
    Human metapneumovirus is a newly discovered pathogen associated with respiratory disease and occurring mainly in children...
  76. Abdullah Brooks W, Erdman D, Terebuh P, Klimov A, Goswami D, Sharmeen A, et al. Human metapneumovirus infection among children, Bangladesh. Emerg Infect Dis. 2007;13:1611-3 pubmed publisher
    We confirmed circulation of human metapneumovirus (HMPV) among children with febrile and respiratory illness in an urban slum in Dhaka, Bangladesh, during active surveillance in 2001...
  77. Heikkinen T, Osterback R, Peltola V, Jartti T, Vainionpaa R. Human metapneumovirus infections in children. Emerg Infect Dis. 2008;14:101-6 pubmed publisher
    Human metapneumovirus (hMPV) is an important cause of lower respiratory tract infections in hospitalized children, but the age-related incidence and effect of hMPV in unselected children in the community have not been evaluated...
  78. Turpin E, Stallknecht D, Slemons R, Zsak L, Swayne D. Evidence of avian metapneumovirus subtype C infection of wild birds in Georgia, South Carolina, Arkansas and Ohio, USA. Avian Pathol. 2008;37:343-51 pubmed publisher
  79. Spetch L, Bowlin T, Casola A. Effect of NMSO3 treatment in a murine model of human metapneumovirus infection. J Gen Virol. 2008;89:2709-12 pubmed publisher
    BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg(-1)) given at the time of infection...
  80. Shen J, Zhu Q, Zeng M, Yu H, Wang X. [Molecular epidemiology of human metapneumovirus in children with acute lower respiratory tract infections in Shanghai]. Zhonghua Liu Xing Bing Xue Za Zhi. 2010;31:447-50 pubmed
    To understand the clinical and molecular epidemiologic features of human metapneumovirus (hMPV) in children with acute lower respiratory tract infection (ALRTI) from Oct. 2006 to Feb. 2008 in Shanghai...
  81. Pilger D, Cantarelli V, Amantea S, Leistner Segal S. Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil. Mem Inst Oswaldo Cruz. 2011;106:56-60 pubmed
    The introduction of newer molecular methods has led to the discovery of new respiratory viruses, such as human metapneumovirus (hMPV) and human bocavirus (hBoV), in respiratory tract specimens...
  82. Zhang J, Dou Y, Wu J, She W, Luo L, Zhao Y, et al. Effects of N-linked glycosylation of the fusion protein on replication of human metapneumovirus in vitro and in mouse lungs. J Gen Virol. 2011;92:1666-75 pubmed publisher
    ..F) protein is an important membrane glycoprotein necessary for cellular entry and replication of human metapneumovirus (hMPV)...
  83. Jartti T, Jartti L, Ruuskanen O, Soderlund Venermo M. New respiratory viral infections. Curr Opin Pulm Med. 2012;18:271-8 pubmed publisher
    ..of respiratory viruses began, and several new respiratory viruses and their subgroups have been found: human metapneumovirus, CoVs NL63 and HKU1, human bocavirus and human rhinovirus C and D groups...
  84. Wei L, Zhu S, Yan X, Wang J, Zhang C, Liu S, et al. Avian metapneumovirus subgroup C infection in chickens, China. Emerg Infect Dis. 2013;19:1092-4 pubmed publisher
    Avian metapneumovirus causes acute respiratory tract infection and reductions in egg production in various avian species...
  85. Loo L, Jumat M, Fu Y, Ayi T, Wong P, Tee N, et al. Evidence for the interaction of the human metapneumovirus G and F proteins during virus-like particle formation. Virol J. 2013;10:294 pubmed publisher
    Human metapneumovirus (HMPV) is now a major cause of lower respiratory infection in children...
  86. Leyrat C, Renner M, Harlos K, Grimes J. Solution and crystallographic structures of the central region of the phosphoprotein from human metapneumovirus. PLoS ONE. 2013;8:e80371 pubmed publisher
    Human metapneumovirus (HMPV) of the family Paramyxoviridae is a major cause of respiratory illness worldwide...
  87. Falsey A. Human metapneumovirus infection in adults. Pediatr Infect Dis J. 2008;27:S80-3 pubmed publisher
    Human metapneumovirus (hMPV) was first identified in 2001 in Dutch children with bronchiolitis. The virus is an RNA virus in the Pneumovirinae subfamily and is most closely related to respiratory syncytial virus...
  88. Broor S, Bharaj P, Chahar H. Human metapneumovirus: a new respiratory pathogen. J Biosci. 2008;33:483-93 pubmed
    Human metapneumovirus is a recently recognized pathogen of acute respiratory tract infection (ARI) in children as well as elderly and immunocompromised adults...
  89. Hustedt J, Vazquez M. The changing face of pediatric respiratory tract infections: how human metapneumovirus and human bocavirus fit into the overall etiology of respiratory tract infections in young children. Yale J Biol Med. 2010;83:193-200 pubmed
    ..Two of these, human metapneumovirus (hMPV) and human bocavirus (HBoV), are of particular clinical interest to pediatric health care providers...
  90. Piyaratna R, Tollefson S, Williams J. Genomic analysis of four human metapneumovirus prototypes. Virus Res. 2011;160:200-5 pubmed publisher
    Human metapneumovirus (HMPV) is an important cause of acute respiratory illness in children. We determined the complete genome sequence of four strains of HMPV representing each of the four lineages...
  91. Feuillet F, Lina B, Rosa Calatrava M, Boivin G. Ten years of human metapneumovirus research. J Clin Virol. 2012;53:97-105 pubmed publisher
    Described for the first time in 2001, human metapneumovirus (hMPV) has become one of the main viral pathogens responsible for acute respiratory tract infections in children but also in the elderly and immuno-compromised patients...
  92. Velayutham T, Kolli D, Ivanciuc T, Garofalo R, Casola A. Critical role of TLR4 in human metapneumovirus mediated innate immune responses and disease pathogenesis. PLoS ONE. 2013;8:e78849 pubmed publisher
    Human metapneumovirus (hMPV) is one of the main causes of acute respiratory tract infections in children, elderly and immunocompromised patients...