mumps virus

Summary

Summary: The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.

Top Publications

  1. Woznik M, Rödner C, Lemon K, Rima B, Mankertz A, Finsterbusch T. Mumps virus small hydrophobic protein targets ataxin-1 ubiquitin-like interacting protein (ubiquilin 4). J Gen Virol. 2010;91:2773-81 pubmed publisher
    The small hydrophobic (SH) protein of mumps virus has been reported to interfere with innate immunity by inhibiting tumour necrosis factor alpha-mediated apoptosis...
  2. Sauder C, Zhang C, Link M, Duprex W, Carbone K, Rubin S. Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence. Vaccine. 2009;27:5822-9 pubmed publisher
    ..Unfortunately, some vaccines derived from inadequately attenuated vaccine strains of mumps virus have caused meningitis in vaccinees, leading to withdrawal of certain vaccine strains from the market, public ..
  3. Jin L, Beard S, Brown D. Genetic heterogeneity of mumps virus in the United Kingdom: identification of two new genotypes. J Infect Dis. 1999;180:829-33 pubmed
    ..transcriptase nested polymerase chain reaction (PCR) was developed to detect the small hydrophobic (SH) gene of mumps virus (MuV)...
  4. Wright K, Dimock K, Brown E. Biological characteristics of genetic variants of Urabe AM9 mumps vaccine virus. Virus Res. 2000;67:49-57 pubmed
    ..The post-vaccination isolates may represent insufficiently attenuated components of the vaccine, while the G(1081) and ts subset of A(1081) viruses may be more fully attenuated. ..
  5. Fanoy E, Cremer J, Ferreira J, Dittrich S, van Lier A, Hahné S, et al. Transmission of mumps virus from mumps-vaccinated individuals to close contacts. Vaccine. 2011;29:9551-6 pubmed publisher
    During a recent mumps epidemic in the Netherlands caused by a genotype D mumps virus strain, we investigated the potential of vaccinated people to spread mumps disease to close contacts...
  6. Mühlemann K. The molecular epidemiology of mumps virus. Infect Genet Evol. 2004;4:215-9 pubmed
    ..Close monitoring of the genotype distribution of MuV and genotype-specific population immunity is needed in the vaccine era. ..
  7. LeBlanc J, Pettipas J, Davidson R, Tipples G, Hiebert J, Hatchette T. Detection of mumps virus RNA by real-time one-step reverse transcriptase PCR using the LightCycler platform. J Clin Microbiol. 2008;46:4049-51 pubmed publisher
    A real-time reverse transcriptase PCR (RT-PCR) assay that targeted both the mumps virus F gene and human RNase P in clinical samples was adapted for use with the LightCycler platform...
  8. Usonis V, Bakasenas V, Denis M. Neutralization activity and persistence of antibodies induced in response to vaccination with a novel mumps strain, RIT 4385. Infection. 2001;29:159-62 pubmed
    ..To ensure that these antibodies had neutralizing activity against wild-type mumps virus, sera were prepared 2 and 18 months after vaccination of 12-24-month-old infants with either Priorix or M-M-R ..
  9. Alirezaie B, Aghaiypour K, Shafyi A. Genetic characterization of RS-12 (S-12), an Iranian isolate of mumps virus, by sequence analysis and comparative genomics of F, SH, and HN genes. J Med Virol. 2008;80:702-10 pubmed publisher
    RS-12 mumps virus strain was isolated in 1986, in monkey kidney cells, from the throat-washing of an Iranian patient and developed to RS-12 vaccine by serial passage of the pathogen in MRC-5 cells...

More Information

Publications86

  1. Dittrich S, Hahne S, van Lier A, Kohl R, Boot H, Koopmans M, et al. Assessment of serological evidence for mumps virus infection in vaccinated children. Vaccine. 2011;29:9271-5 pubmed publisher
    It is estimated that at least one-third of mumps virus infections in non-vaccinated individuals are asymptomatic. Little information is available whether this proportion is the same among those vaccinated...
  2. Herrera E, Barcenas P, Hernández R, Méndez A, Pérez Ishiwara G, Barrón B. A 176 amino acid polypeptide derived from the mumps virus HN ectodomain shows immunological and biological properties similar to the HN protein. Virol J. 2010;7:195 pubmed publisher
    The hemagglutinin-neuraminidase (HN) protein is the major antigenic determinant of the Mumps virus (MuV) and plays an important role in the viral infectious cycle through its hemagglutination/hemadsorption (HA/HD) and neuraminidase (NA) ..
  3. Tecle T, Bottiger B, Orvell C, Johansson B. Characterization of two decades of temporal co-circulation of four mumps virus genotypes in Denmark: identification of a new genotype. J Gen Virol. 2001;82:2675-80 pubmed
    ..the small hydrophobic (SH) protein gene and the deduced 57 amino acid sequences were aligned with sequences of mumps virus strains published previously...
  4. Amexis G, Rubin S, Chizhikov V, Pelloquin F, Carbone K, Chumakov K. Sequence diversity of Jeryl Lynn strain of mumps virus: quantitative mutant analysis for vaccine quality control. Virology. 2002;300:171-9 pubmed
    ..Based on the findings presented here, it is proposed that the substrain composition of Jeryl Lynn vaccine can be monitored as a part of its quality control to ensure consistency of the vaccine. ..
  5. Ulane C, Rodriguez J, Parisien J, Horvath C. STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. J Virol. 2003;77:6385-93 pubmed
    b>Mumps virus is a common infectious agent of humans, causing parotitis, meningitis, encephalitis, and orchitis...
  6. Lim C, Chan K, Goh K, Chow V. Hemagglutinin-neuraminidase sequence and phylogenetic analyses of mumps virus isolates from a vaccinated population in Singapore. J Med Virol. 2003;70:287-92 pubmed
    ..the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isolates from patients with parotitis in Singapore were determined and compared with those of known vaccine ..
  7. Clarke D, Sidhu M, Johnson J, Udem S. Rescue of mumps virus from cDNA. J Virol. 2000;74:4831-8 pubmed
    A complete DNA copy of the genome of a Jeryl Lynn strain of mumps virus (15,384 nucleotides) was assembled from cDNA fragments such that an exact antigenome RNA could be generated following transcription by T7 RNA polymerase and cleavage ..
  8. Atrasheuskaya A, Kulak M, Rubin S, Ignatyev G. Mumps vaccine failure investigation in Novosibirsk, Russia, 2002-2004. Clin Microbiol Infect. 2007;13:670-6 pubmed
    ..b>Mumps virus-specific RT-PCR testing of saliva was performed for 18 cases of mumps...
  9. Rubin S, Mauldin J, Chumakov K, Vanderzanden J, Iskow R, Carbone K. Serological and phylogenetic evidence of monotypic immune responses to different mumps virus strains. Vaccine. 2006;24:2662-8 pubmed
    ..epidemics in many countries with ongoing vaccination programs along with evidence of antigenic diversity among mumps virus strains have recently challenged the assumption that mumps virus is serologically monotypic...
  10. Dejucq N, Jegou B. Viruses in the mammalian male genital tract and their effects on the reproductive system. Microbiol Mol Biol Rev. 2001;65:208-31 ; first and second pages, table of contents pubmed
    ..Progress in all these domains is essential for the development of new treatment strategies to eradicate viruses and to correct the virus-induced dysfunction of the endocrine system. ..
  11. Reyes Leyva J, Baños R, Borraz Argüello M, Santos López G, Rosas N, Alvarado G, et al. Amino acid change 335 E to K affects the sialic-acid-binding and neuraminidase activities of Urabe AM9 mumps virus hemagglutinin-neuraminidase glycoprotein. Microbes Infect. 2007;9:234-40 pubmed
    ..Therefore, HN-K335 variant presented a neuraminidase activity level 11-fold higher than that of HN-E335 variant. In conclusion, the mutation affects the receptor-binding and neuraminidase activities of Urabe AM9 mumps virus variants.
  12. Bonebrake A, Silkaitis C, Monga G, Galat A, Anderson J, Trad J, et al. Effects of mumps outbreak in hospital, Chicago, Illinois, USA, 2006. Emerg Infect Dis. 2010;16:426-32 pubmed publisher
    ..The outbreak resulted in substantial staffing and financial challenges for the institution that may have been minimized with readily accessible electronic employee vaccination records and adherence to infection control recommendations...
  13. Puri M, Lemon K, Duprex W, Rima B, Horvath C. A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting. J Virol. 2009;83:6347-56 pubmed publisher
    b>Mumps virus, like other paramyxoviruses in the Rubulavirus genus, encodes a V protein that can assemble a ubiquitin ligase complex from cellular components, leading to the destruction of cellular signal transducer and activator of ..
  14. Nöjd J, Tecle T, Samuelsson A, Orvell C. Mumps virus neutralizing antibodies do not protect against reinfection with a heterologous mumps virus genotype. Vaccine. 2001;19:1727-31 pubmed
    ..b>Mumps virus RNA of genotype A character based on the SH (small hydrophobic) protein gene classification was demonstrated in ..
  15. Xu P, Luthra P, Li Z, Fuentes S, D Andrea J, Wu J, et al. The V protein of mumps virus plays a critical role in pathogenesis. J Virol. 2012;86:1768-76 pubmed publisher
    b>Mumps virus (MuV) causes an acute infection in humans characterized by a wide array of symptoms ranging from relatively mild manifestations, such as parotitis, to more-severe complications, such as meningitis and encephalitis...
  16. Palacios G, Jabado O, Cisterna D, de Ory F, Renwick N, Echevarria J, et al. Molecular identification of mumps virus genotypes from clinical samples: standardized method of analysis. J Clin Microbiol. 2005;43:1869-78 pubmed
    ..of the gene encoding the small hydrophobic protein (SH gene), was developed to allow rapid characterization of mumps virus in clinical samples...
  17. Malik T, Shegogue C, Werner K, Ngo L, Sauder C, Zhang C, et al. Discrimination of mumps virus small hydrophobic gene deletion effects from gene translation effects on virus virulence. J Virol. 2011;85:6082-5 pubmed publisher
    ..To investigate the role of the mumps virus (MuV) SH protein in virulence, multiple stop codons were introduced into the open reading frame (ORF) of a MuV ..
  18. Takahashi M, Nakayama T, Kashiwagi Y, Takami T, Sonoda S, Yamanaka T, et al. Single genotype of measles virus is dominant whereas several genotypes of mumps virus are co-circulating. J Med Virol. 2000;62:278-85 pubmed
    ..Similarly, mumps virus strains have been divided into two genotypes with three subtypes (B1, B2, B3, and D) under the proposed ..
  19. Sanz J, Mosquera M, Echevarria J, Fernandez M, Herranz N, Palacios G, et al. Sensitivity and specificity of immunoglobulin G titer for the diagnosis of mumps virus in infected patients depending on vaccination status. APMIS. 2006;114:788-94 pubmed
    ..The detection of mumps virus RNA in saliva by RT-PCR was used as reference...
  20. Backhouse J, Gidding H, McIntyre P, Gilbert G. Evaluation of two enzyme immunoassays for detection of immunoglobulin G antibodies to mumps virus. Clin Vaccine Immunol. 2006;13:764-7 pubmed
    ..We conclude that the Microimmune ELISA is a more appropriate assay than the Enzygnost ELISA for estimation of mumps seroprevalence. ..
  21. Young D, Galiano M, Lemon K, Chen Y, Andrejeva J, Duprex W, et al. Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist. J Gen Virol. 2009;90:2731-8 pubmed publisher
    Although the Enders strain of mumps virus (MuV) encodes a functional V protein that acts as an interferon (IFN) antagonist, in multi-cycle growth assays MuV Enders grew poorly in naïve ('IFN-competent' Hep2) cells but grew to high ..
  22. Rubin S, Pletnikov M, Taffs R, Snoy P, Kobasa D, Brown E, et al. Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans. J Virol. 2000;74:5382-4 pubmed
    Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test...
  23. Bitsko R, Cortese M, Dayan G, Rota P, Lowe L, Iversen S, et al. Detection of RNA of mumps virus during an outbreak in a population with a high level of measles, mumps, and rubella vaccine coverage. J Clin Microbiol. 2008;46:1101-3 pubmed publisher
    The duration of mumps virus RNA detection was studied during a mumps outbreak in a highly vaccinated university population...
  24. Allwinn R, Zeidler B, Steinhagen K, Rohwäder E, Wicker S, Rabenau H, et al. Assessment of mumps virus-specific antibodies by different serological assays: which test correlates best with mumps immunity?. Eur J Clin Microbiol Infect Dis. 2011;30:1223-8 pubmed publisher
    ..coverage and calculated seropositivity rates are not effective enough to interrupt the transmission of the mumps virus. The often-occurring mumps outbreaks, some in highly vaccinated populations, may not always demonstrate vaccine ..
  25. Kubota T, Yokosawa N, Yokota S, Fujii N, Tashiro M, Kato A. Mumps virus V protein antagonizes interferon without the complete degradation of STAT1. J Virol. 2005;79:4451-9 pubmed
    b>Mumps virus (MuV) has been shown to antagonize the antiviral effects of interferon (IFN) through proteasome-mediated complete degradation of STAT1 by using the viral V protein (T. Kubota et al., Biochem. Biophys. Res. Commun...
  26. Santos López G, Scior T, Borraz Argüello M, Vallejo Ruiz V, Herrera Camacho I, Tapia Ramírez J, et al. Structure-function analysis of two variants of mumps virus hemagglutinin-neuraminidase protein. Braz J Infect Dis. 2009;13:24-34 pubmed
    ..position 1081 in the hemagglutinin-neuraminidase (HN) gene has been associated with neurovirulence of Urabe AM9 mumps virus vaccine...
  27. Rosas Murrieta N, Herrera Camacho I, Palma Ocampo H, Santos López G, Reyes Leyva J. Interaction of mumps virus V protein variants with STAT1-STAT2 heterodimer: experimental and theoretical studies. Virol J. 2010;7:263 pubmed publisher
    b>Mumps virus V protein has the ability to inhibit the interferon-mediated antiviral response by inducing degradation of STAT proteins...
  28. Johnson J, Capraro G, Parks G. Differential mechanisms of complement-mediated neutralization of the closely related paramyxoviruses simian virus 5 and mumps virus. Virology. 2008;376:112-23 pubmed publisher
    ..pathways in the in vitro neutralization of three closely related paramyxoviruses, Simian Virus 5 (SV5), Mumps virus (MuV) and Human Parainfluenza virus type 2 (HPIV2) was investigated...
  29. Saika S, Kidokoro M, Ohkawa T, Aoki A, Suzuki K. Pathogenicity of mumps virus in the marmoset. J Med Virol. 2002;66:115-22 pubmed
    The neurovirulence of two mumps virus strains was compared using marmosets...
  30. Forcic D, Kosutic Gulija T, Santak M, Jug R, Ivancic Jelecki J, Markusic M, et al. Comparisons of mumps virus potency estimates obtained by 50% cell culture infective dose assay and plaque assay. Vaccine. 2010;28:1887-92 pubmed publisher
    ..We compared the potency estimates obtained by plaque and CCID(50) assays for nine mumps virus strains that produce different cytopathic effects in Vero cells...
  31. Ivancic Jelecki J, Santak M, Forcic D. Variability of hemagglutinin-neuraminidase and nucleocapsid protein of vaccine and wild-type mumps virus strains. Infect Genet Evol. 2008;8:603-13 pubmed publisher
    The mumps virus (MuV) molecular evolution is characterized by the co-circulation of numerous distinct strains...
  32. Sauder C, Zhang C, Ngo L, Werner K, Lemon K, Duprex W, et al. Gene-specific contributions to mumps virus neurovirulence and neuroattenuation. J Virol. 2011;85:7059-69 pubmed publisher
    b>Mumps virus (MuV) is highly neurotropic and was the leading cause of aseptic meningitis in the Western Hemisphere prior to widespread use of live attenuated MuV vaccines...
  33. Somboonthum P, Yoshii H, Okamoto S, Koike M, Gomi Y, Uchiyama Y, et al. Generation of a recombinant Oka varicella vaccine expressing mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine. Vaccine. 2007;25:8741-55 pubmed
    We constructed a recombinant varicella-zoster virus (VZV) Oka vaccine strain (vOka) that contained the mumps virus (MuV) hemagglutinin-neuraminidase (HN) gene, inserted into the site of the ORF 13 gene by using the bacterial artificial ..
  34. Johnson J, Grant K, Parks G. The paramyxoviruses simian virus 5 and mumps virus recruit host cell CD46 to evade complement-mediated neutralization. J Virol. 2009;83:7602-11 pubmed publisher
    ..Similar results were obtained for the closely related mumps virus (MuV), except that MuV particles derived from CHO-CD46 cells had higher C4b cofactor activity than SV5 virions...
  35. Jeevan M, Sambantham S, Thangam M. Characterisation of mumps virus genotype C among patients with mumps in India. Indian J Med Microbiol. 2013;31:290-2 pubmed publisher
    ..This is the first report in India to suggest that genotype C is responsible for the present mumps infection. Thus, the present MMR vaccine must be revamped and optimised for its efficacy to prevent any future mumps epidemics. ..
  36. Rosas Murrieta N, Santos López G, Reyes Leyva J, Jurado F, Herrera Camacho I. Modulation of apoptosis by V protein mumps virus. Virol J. 2011;8:224 pubmed publisher
    The Urabe AM9 vaccine strain of mumps virus contains two variants of V protein: VWT (of HN-A1081 viral population) and VGly (of HN-G1081). The V protein is a promoting factor of viral replication by blocking the IFN antiviral pathway...
  37. Tecle T, Mickiene A, Johansson B, Lindquist L, Orvell C. Molecular characterisation of two mumps virus genotypes circulating during an epidemic in Lithuania from 1998 to 2000. Arch Virol. 2002;147:243-53 pubmed
    ..This variant was designated C2 and it was associated with parotitis. The amino acid alanine at position 29 and serine in position 48 of the C2 genotype may constitute a marker of low neurovirulence compared to other genotype C strains. ..
  38. Tesovic G, Lesnikar V. Aseptic meningitis after vaccination with L-Zagreb mumps strain--virologically confirmed cases. Vaccine. 2006;24:6371-3 pubmed
  39. Orvell C, Tecle T, Johansson B, Saito H, Samuelson A. Antigenic relationships between six genotypes of the small hydrophobic protein gene of mumps virus. J Gen Virol. 2002;83:2489-96 pubmed
    Six different genotypes of mumps virus, A, C, D, G, H and I, genotyped on the basis of the small hydrophobic protein gene sequence, were subjected to antigenic comparison...
  40. Le Goffic R, Mouchel T, Ruffault A, Patard J, Jégou B, Samson M. Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells. J Virol. 2003;77:3297-300 pubmed
    b>Mumps virus is responsible for sterility...
  41. Rubin S, Amexis G, Pletnikov M, Li Z, Vanderzanden J, Mauldin J, et al. Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype. J Virol. 2003;77:11616-24 pubmed
    b>Mumps virus is highly neurotropic and, prior to widespread vaccination programs, was the major cause of viral meningitis in the United States...
  42. Inou Y, Nakayama T, Yoshida N, Uejima H, Yuri K, Kamada M, et al. Molecular epidemiology of mumps virus in Japan and proposal of two new genotypes. J Med Virol. 2004;73:97-104 pubmed
    We isolated 872 strains of mumps virus from naso-pharyngeal secretions in seven different districts of Japan from January 2000 to July 2001...
  43. Hviid A, Rubin S, Mühlemann K. Mumps. Lancet. 2008;371:932-44 pubmed publisher
    Mumps is a common childhood infection caused by the mumps virus. The hallmark of infection is swelling of the parotid gland...
  44. Okafuji T, Yoshida N, Fujino M, Motegi Y, Ihara T, Ota Y, et al. Rapid diagnostic method for detection of mumps virus genome by loop-mediated isothermal amplification. J Clin Microbiol. 2005;43:1625-31 pubmed
    ..We detected mumps virus RNA corresponding to 0...
  45. Santos López G, Cruz C, Pazos N, Vallejo V, Reyes Leyva J, Tapia Ramírez J. Two clones obtained from Urabe AM9 mumps virus vaccine differ in their replicative efficiency in neuroblastoma cells. Microbes Infect. 2006;8:332-9 pubmed
    A high rate of post-vaccinal aseptic meningitis for Urabe AM9 mumps virus strain is well documented. This strain is composed of two virus variants differing at the nt 1081 (A/G) region in the hemagglutinin-neuraminidase (HN) gene...
  46. Santos C, Ishida M, Foster P, Sallum M, Benega M, Borges D, et al. Detection of a new mumps virus genotype during parotitis epidemic of 2006-2007 in the state of São Paulo, Brazil. J Med Virol. 2008;80:323-9 pubmed
    Nucleotide sequence analyses of the SH gene of 18 mumps virus isolates collected in the 2006-2007 parotitis epidemic in the state of São Paulo identified a new genotype, designated genotype M...
  47. Kubota T, Yokosawa N, Yokota S, Fujii N. C terminal CYS-RICH region of mumps virus structural V protein correlates with block of interferon alpha and gamma signal transduction pathway through decrease of STAT 1-alpha. Biochem Biophys Res Commun. 2001;283:255-9 pubmed
    ..IFN)-alpha/gamma signal transduction pathway is blocked in several cell lines persistently infected with mumps virus (MV) through decrease of STAT-1alpha...
  48. Cox R, Green T, Purushotham S, Deivanayagam C, Bedwell G, Prevelige P, et al. Structural and functional characterization of the mumps virus phosphoprotein. J Virol. 2013;87:7558-68 pubmed publisher
    ..We systematically mapped the domains in mumps virus (MuV) P and investigated their interactions with nucleocapsid-like particles (NLPs)...
  49. Cox R, Green T, Qiu S, Kang J, Tsao J, Prevelige P, et al. Characterization of a mumps virus nucleocapsidlike particle. J Virol. 2009;83:11402-6 pubmed publisher
    The nucleocapsid protein (NP) of mumps virus (MuV), a paramyxovirus, was coexpressed with the phosphoprotein (P) in Escherichia coli. The NP and P proteins form a soluble complex containing RNA...
  50. Orvell C, Alsheikhly A, Kalantari M, Johansson B. Characterization of genotype-specific epitopes of the HN protein of mumps virus. J Gen Virol. 1997;78 ( Pt 12):3187-93 pubmed
    The SBL-1 strain of mumps virus, grouping with genotype A on the basis of the small hydrophobic protein gene sequence, was grown in the presence of three different monoclonal antibodies...
  51. Rubin S, Snoy P, Wright K, Brown E, Reeve P, Beeler J, et al. The mumps virus neurovirulence safety test in Rhesus monkeys: a comparison of mumps virus strains. J Infect Dis. 1999;180:521-5 pubmed
    ..However, results with several mumps virus MNVTs have raised questions as to whether the test can reliably discriminate neurovirulent from ..
  52. Tesovic G, Poljak M, Lunar M, Kocjan B, Seme K, Vukić B, et al. Horizontal transmission of the Leningrad-Zagreb mumps vaccine strain: a report of three cases. Vaccine. 2008;26:1922-5 pubmed publisher
  53. Sauder C, Vandenburgh K, Iskow R, Malik T, Carbone K, Rubin S. Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity. Virology. 2006;350:48-57 pubmed
    b>Mumps virus is a highly neurotropic virus with evidence of central nervous system invasion (CNS) in approximately half of all cases of infection...
  54. Nishio M, Garcin D, Simonet V, Kolakofsky D. The carboxyl segment of the mumps virus V protein associates with Stat proteins in vitro via a tryptophan-rich motif. Virology. 2002;300:92-9 pubmed
    ..Our results suggest that rubulavirus V proteins may be related to both the C and the V proteins of respiroviruses. ..
  55. Le Tortorec A, Denis H, Satie A, Patard J, Ruffault A, Jegou B, et al. Antiviral responses of human Leydig cells to mumps virus infection or poly I:C stimulation. Hum Reprod. 2008;23:2095-103 pubmed publisher
    ..In men mumps virus infects Leydig cells and has deleterious effects on testosterone production and spermatogenesis...
  56. Xu P, Li Z, Sun D, Lin Y, Wu J, Rota P, et al. Rescue of wild-type mumps virus from a strain associated with recent outbreaks helps to define the role of the SH ORF in the pathogenesis of mumps virus. Virology. 2011;417:126-36 pubmed publisher
    b>Mumps virus (MuV) causes acute infections in humans. In recent years, MuV has caused epidemics among highly vaccinated populations. The largest outbreak in the U.S...
  57. Matsubara K, Iwata S, Nakayama T. Antibodies against mumps virus component proteins. J Infect Chemother. 2012;18:466-71 pubmed publisher
    ..IF antibodies against F and HN proteins were considered to have a strong association with NT antibodies, and those against N protein were considered to have a strong association with EIA antibodies. ..
  58. Hanaoka M, Hisano M, Watanabe N, Sugawara K, Kambe Y, Kanda E, et al. Changes in the prevalence of the measles, rubella, varicella-zoster, and mumps virus antibody titers in Japanese pregnant women. Vaccine. 2013;31:2343-7 pubmed publisher
    ..We recommend that women be vaccinated after delivery, as these vaccines are live, and thereby, are contraindicated during pregnancy...
  59. Kutty P, Kruszon Moran D, Dayan G, Alexander J, Williams N, Garcia P, et al. Seroprevalence of antibody to mumps virus in the US population, 1999-2004. J Infect Dis. 2010;202:667-74 pubmed publisher
    ..To understand prior mumps seroprevalence and factors associated with the presence of antibody to mumps virus, data from the 1999-2004 National Health and Nutrition Examination Survey (NHANES) were analyzed...
  60. Atrasheuskaya A, Blatun E, Kulak M, Atrasheuskaya A, Karpov I, Rubin S, et al. Investigation of mumps vaccine failures in Minsk, Belarus, 2001-2003. Vaccine. 2007;25:4651-8 pubmed
    ..A genotype H1 mumps virus (MuV) strain was identified in all patients...
  61. Vaidya S, Brown D, Jin L, Samuel D, Andrews N, Brown K. Development of a focus reduction neutralization test (FRNT) for detection of mumps virus neutralizing antibodies. J Virol Methods. 2010;163:153-6 pubmed publisher
    ..150 microL), and the possibility of automation using 96-well plates. FRNT appears to be a good substitute for PRNT for characterising the immune response to mumps and for vaccine efficacy studies...
  62. Afzal M, Pickford A, Forsey T, Heath A, Minor P. The Jeryl Lynn vaccine strain of mumps virus is a mixture of two distinct isolates. J Gen Virol. 1993;74 ( Pt 5):917-20 pubmed
    Sequence analysis of the region of the mumps virus genome encoding the putative small hydrophobic protein gene confirms that it is a highly variable region. Jeryl Lynn, the mumps vaccine strain used in the U.K...
  63. Takeuchi K, Tanabayashi K, Hishiyama M, Yamada A. The mumps virus SH protein is a membrane protein and not essential for virus growth. Virology. 1996;225:156-62 pubmed
    ..synthesized based on the deduced N-terminal and C-terminal amino acid sequences of the SH proteins of the mumps virus, the SH protein was detected in mumps virus-infected cells...
  64. Jin L, Beard S, Hale A, Knowles W, Brown D. The genomic sequence of a contemporary wild-type mumps virus strain. Virus Res. 2000;70:75-83 pubmed
    ..Although, monotypic, genetic variants of mumps virus (MuV) have been described based on comparison of the SH gene sequences, and at least seven genotypes have been ..
  65. Rosas Murrieta N, Herrera Camacho I, Vallejo Ruiz V, Millán Pérez Peña L, Cruz C, Tapia Ramírez J, et al. Differential sensitivity to interferon influences the replication and transcription of Urabe AM9 mumps virus variants in nerve cells. Microbes Infect. 2007;9:864-72 pubmed
    Urabe AM9 mumps virus vaccine causes post-vaccination meningitis. Two variants of Urabe AM9 virus differ in their replication efficiency in human nerve cells, HN-A(1081) variant being more neurotropic than HN-G(1081)...
  66. Yoshida N, Fujino M, Miyata A, Nagai T, Kamada M, Sakiyama H, et al. Mumps virus reinfection is not a rare event confirmed by reverse transcription loop-mediated isothermal amplification. J Med Virol. 2008;80:517-23 pubmed publisher
    ..Another 25 patients were enrolled as a primary infection group. Mumps virus was isolated in 5 (17%) and the genome was detected in 12 (41%) of 29 in the reinfection group...
  67. Malik T, Wolbert C, Mauldin J, Sauder C, Carbone K, Rubin S. Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strain. J Gen Virol. 2007;88:2533-41 pubmed
    ..These data suggest a polygenic component (i.e. specific and inter-related roles of these amino acid changes) to MuV neuroattenuation. ..
  68. Dayan G, Quinlisk M, Parker A, Barskey A, Harris M, Schwartz J, et al. Recent resurgence of mumps in the United States. N Engl J Med. 2008;358:1580-9 pubmed publisher
    ..A more effective mumps vaccine or changes in vaccine policy may be needed to avert future outbreaks and achieve the elimination of mumps. ..
  69. Tanabayashi K, Takeuchi K, Hishiyama M, Okazaki K, Yamada A. Molecular cloning and sequence analysis of the mumps virus gene encoding the L protein and the trailer sequence. Virology. 1992;188:926-30 pubmed
    We have cloned and determined the nucleotide sequences of the seventh gene of the Miyahara strain of mumps virus (MuV) encoding the L protein...
  70. Ivancic J, Gulija T, Forcic D, Baricevic M, Jug R, Mesko Prejac M, et al. Genetic characterization of L-Zagreb mumps vaccine strain. Virus Res. 2005;109:95-105 pubmed
    ..L-Zagreb nucleotide and deduced protein sequences were compared with other mumps virus sequences obtained from the GenBank...
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    ..For both measles and mumps virus N, truncated proteins encompassing amino acids 1 to 375 assemble into nucleocapsid-like particles within the ..
  72. Slibinskas R, Zvirbliene A, Gedvilaite A, Samuel D, Jin L, Beard S, et al. Synthesis of mumps virus nucleocapsid protein in yeast Pichia pastoris. J Biotechnol. 2003;103:43-9 pubmed
    The expression of mumps virus nucleocapsid protein in yeast Pichia pastoris was investigated. Viral nucleocapsid proteins usually elicit a strong long-term humoral immune response in patients and experimental animals...
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    ..i.) and significantly lost by 24 h p.i. in FL cells acutely infected with mumps virus (MuV)...
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    Four protein fragments which span the entire hemagglutinin-neuraminidase protein (HN) of mumps virus were expressed in HeLa cells and cell extracts were tested for their capability to induce neutralizing antibodies in mice...
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    ..intervals after vaccination and assayed the ability of these samples to neutralize the genotype A Jeryl Lynn mumps virus vaccine strain and a genotype G wild-type virus obtained during the mumps outbreak that occurred in the United ..
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    ..Genetic analysis of mumps virus strain variability demonstrated that a single genotype, genotype G, was circulating, and it was also detected ..
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    ..L; Ile-736-->Val) proteins, are associated with attenuation of a neurovirulent clinical isolate of mumps virus (88-1961) following serial passage in vitro...