sendai virus


Summary: The type species of RESPIROVIRUS in the subfamily PARAMYXOVIRINAE. It is the murine version of HUMAN PARAINFLUENZA VIRUS 1, distinguished by host range.

Top Publications

  1. Bousse T, Chambers R, Scroggs R, Portner A, Takimoto T. Human parainfluenza virus type 1 but not Sendai virus replicates in human respiratory cells despite IFN treatment. Virus Res. 2006;121:23-32 pubmed
    b>Sendai virus (SeV) and human parainfluenza virus type I (hPIV1) are highly homologous but have distinct host ranges, murine versus human...
  2. Zhu J, Coyne C, Sarkar S. PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and ?-catenin. EMBO J. 2011;30:4838-49 pubmed publisher
    ..Knockdown of PKC? in various human cells, including primary cells, inhibited Sendai virus (SeV)-mediated IFN induction and enhanced virus replication...
  3. Hou F, Sun L, Zheng H, Skaug B, Jiang Q, Chen Z. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell. 2011;146:448-61 pubmed publisher
    ..These results suggest that a prion-like conformational switch of MAVS activates and propagates the antiviral signaling cascade. ..
  4. Genin P, Lin R, Hiscott J, Civas A. Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7. Mol Cell Biol. 2009;29:3435-50 pubmed publisher
    ..This regulatory mechanism contributes to differential expression of IFN-A genes and may be critical for alpha interferon production in different cell types by RIG-I-dependent signals, leading to innate antiviral immune responses. ..
  5. Hasegawa Y, Kinoh H, Iwadate Y, Onimaru M, Ueda Y, Harada Y, et al. Urokinase-targeted fusion by oncolytic Sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-? gene. Mol Ther. 2010;18:1778-86 pubmed publisher
    ..Here, we show the potential of our new and powerful recombinant Sendai virus (rSeV) showing uPA-specific cell-to-cell fusion activity [rSeV/dMFct14 (uPA2), named "BioKnife"] for ..
  6. Kinoh H, Inoue M, Komaru A, Ueda Y, Hasegawa M, Yonemitsu Y. Generation of optimized and urokinase-targeted oncolytic Sendai virus vectors applicable for various human malignancies. Gene Ther. 2009;16:392-403 pubmed publisher
    We previously reported the development of a prototype 'oncolytic Sendai virus (SeV) vector' formed by introducing two major genomic modifications to the original SeV, namely deletion of the matrix (M) gene to avoid budding of secondary ..
  7. Nishimura K, Segawa H, Goto T, Morishita M, Masago A, Takahashi H, et al. Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus. J Biol Chem. 2007;282:27383-91 pubmed
    ..This system is based on the RNA genome of a noncytopathic variant Sendai virus strain, Cl.151...
  8. Luque L, Bridges O, Mason J, Boyd K, Portner A, Russell C. Residues in the heptad repeat a region of the fusion protein modulate the virulence of Sendai virus in mice. J Virol. 2010;84:810-21 pubmed publisher
    ..the results show that residues in the heptad repeat A region of the F protein modulate the virulence of Sendai virus in mice by influencing both the spread and clearance of the virus and the extent and severity of inflammation...
  9. You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, et al. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat Immunol. 2009;10:1300-8 pubmed publisher
    ..The PCBP2-AIP4 axis defines a new signaling cascade for MAVS degradation and 'fine tuning' of antiviral innate immunity. ..

More Information


  1. Fujita S, Eguchi A, Okabe J, Harada A, Sasaki K, Ogiwara N, et al. Sendai virus-mediated gene delivery into hepatocytes via isolated hepatic perfusion. Biol Pharm Bull. 2006;29:1728-34 pubmed
    The recombinant Sendai virus vector is a promising tool for human gene therapy, capable of inducing high-level expression of therapeutic genes in tissue cells in situ...
  2. Ferrari S, Griesenbach U, Iida A, Farley R, Wright A, Zhu J, et al. Sendai virus-mediated CFTR gene transfer to the airway epithelium. Gene Ther. 2007;14:1371-9 pubmed
    ..We have shown that recombinant Sendai virus (SeV) is highly efficient in mediating gene transfer to differentiated airway epithelial cells, because of its ..
  3. Paz S, Vilasco M, Arguello M, Sun Q, Lacoste J, Nguyen T, et al. Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter. Mol Cell Biol. 2009;29:3401-12 pubmed publisher
    ..MAVS is ubiquitinated following Sendai virus infection, and K63-linked ubiquitination of lysine 500 (K500) of MAVS mediates recruitment of IKKepsilon to the ..
  4. Kaneda Y. Applications of Hemagglutinating Virus of Japan in therapeutic delivery systems. Expert Opin Drug Deliv. 2008;5:221-33 pubmed publisher
    ..The Hemagglutinating Virus of Japan (HVJ; Sendai virus) envelope vector was developed using fusion-competent inactivated HVJ particle...
  5. Strahle L, Garcin D, Kolakofsky D. Sendai virus defective-interfering genomes and the activation of interferon-beta. Virology. 2006;351:101-11 pubmed
    The ability of some Sendai virus stocks to strongly activate IFNbeta has long been known to be associated with defective-interfering (DI) genomes...
  6. Yount J, Kraus T, Horvath C, Moran T, LOPEZ C. A novel role for viral-defective interfering particles in enhancing dendritic cell maturation. J Immunol. 2006;177:4503-13 pubmed
    ..b>Sendai virus strain Cantell has a particularly strong ability to mature DCs independently of type I IFNs and TLR signaling, ..
  7. Goto T, Morishita M, Nishimura K, Nakanishi M, Kato A, Ehara J, et al. Novel mucosal insulin delivery systems based on fusogenic liposomes. Pharm Res. 2006;23:384-91 pubmed
    ..capable of introducing their contents directly into the cytoplasm with the aid of envelope glycoproteins of Sendai virus (SeV)...
  8. Shibata S, Okano S, Yonemitsu Y, Onimaru M, Sata S, Nagata Takeshita H, et al. Induction of efficient antitumor immunity using dendritic cells activated by recombinant Sendai virus and its modulation by exogenous IFN-beta gene. J Immunol. 2006;177:3564-76 pubmed
    ..We here report a unique, representative, and powerful method to activate DCs, namely recombinant Sendai virus-modified DCs (SeV/DC), for cancer immunotherapy...
  9. Irie T, Nagata N, Yoshida T, Sakaguchi T. Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles. Virology. 2008;374:495-505 pubmed publisher
    The Sendai virus (SeV) C proteins are a nested set of four accessory proteins, C', C, Y1, and Y2, encoded on the P mRNA from an alternate reading frame...
  10. Mitomo K, Griesenbach U, Inoue M, Somerton L, Meng C, Akiba E, et al. Toward gene therapy for cystic fibrosis using a lentivirus pseudotyped with Sendai virus envelopes. Mol Ther. 2010;18:1173-82 pubmed publisher
    ..for CF gene therapy, a simian immunodeficiency virus (SIV) was pseudotyped with envelope proteins from Sendai virus (SeV), which is known to efficiently transduce unconditioned airway epithelial cells from the apical side...
  11. Ryan L, Dai J, Yin Z, Megjugorac N, Uhlhorn V, Yim S, et al. Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity. J Leukoc Biol. 2011;90:343-56 pubmed publisher
    ..of hBD-1 peptide and mRNA as early as 2 h following infection of purified cells and PBMCs with PR8, HSV-1, and Sendai virus. However, treatment of primary NHBE cells with influenza resulted in a 50% decrease in hBD-1 mRNA levels, as ..
  12. Yoshida A, Sakaguchi T, Irie T. Passage of a Sendai virus recombinant in embryonated chicken eggs leads to markedly rapid accumulation of U-to-C transitions in a limited region of the viral genome. PLoS ONE. 2012;7:e49968 pubmed publisher
    ..As for Sendai virus (SeV), the C proteins, a nested set of four polypeptides C', C, Y1, and Y2, have been shown to exert multiple ..
  13. Shornick L, Wells A, Zhang Y, Patel A, Huang G, Takami K, et al. Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection. J Immunol. 2008;180:3319-28 pubmed
    ..Here we use a common mouse paramyxovirus (Sendai virus) to show that a prominent early event in respiratory paramyxoviral infection is activation of the IFN-signaling ..
  14. Ordureau A, Enesa K, Nanda S, Le François B, Peggie M, Prescott A, et al. DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA. J Biol Chem. 2013;288:24569-80 pubmed publisher
    ..IRF7, that it is required for the transcription of the IFNβ gene and IFNβ secretion in MEFs infected with Sendai virus or transfected with poly(I:C). DEAF1 is also needed for TLR3-dependent IFNβ production...
  15. Simon A, Moritoh K, Torigoe D, Asano A, Sasaki N, Agui T. Multigenic control of resistance to Sendai virus infection in mice. Infect Genet Evol. 2009;9:1253-9 pubmed publisher
    Experimental infection of mice with Sendai virus (SeV) is frequently used as a model of viral pathogenesis of human respiratory disease...
  16. Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, et al. Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming. J Biol Chem. 2011;286:4760-71 pubmed publisher
    ..Here we report the development of a novel replication-defective and persistent Sendai virus (SeVdp) vector based on a noncytopathic variant virus, which fulfills all of these requirements for cell ..
  17. Seth R, Sun L, Ea C, Chen Z. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell. 2005;122:669-82 pubmed
    ..The transmembrane domain targets MAVS to the mitochondria, implicating a new role of mitochondria in innate immunity...
  18. Wang X, Hussain S, Wang E, Wang X, Li M, Garcia Sastre A, et al. Lack of essential role of NF-kappa B p50, RelA, and cRel subunits in virus-induced type 1 IFN expression. J Immunol. 2007;178:6770-6 pubmed
    ..of the NF-kappaB family, we investigated NF-kappaB function in regulating type 1 IFN expression in response to Sendai virus and Newcastle disease virus infection...
  19. Baum A, Sachidanandam R, Garcia Sastre A. Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing. Proc Natl Acad Sci U S A. 2010;107:16303-8 pubmed publisher
    ..Our analysis for the first time identifies RIG-I PAMPs under natural infection conditions and implies that full-length genomes of single segmented RNA virus families are not bound by RIG-I during infection. ..
  20. Houben K, Marion D, Tarbouriech N, Ruigrok R, Blanchard L. Interaction of the C-terminal domains of sendai virus N and P proteins: comparison of polymerase-nucleocapsid interactions within the paramyxovirus family. J Virol. 2007;81:6807-16 pubmed
    Interaction of the C-terminal domains of Sendai virus (SeV) P and N proteins is crucial for RNA synthesis by correctly positioning the polymerase complex (L+P) onto the nucleocapsid (N/RNA)...
  21. Murphy A, Grdzelishvili V. Identification of sendai virus L protein amino acid residues affecting viral mRNA cap methylation. J Virol. 2009;83:1669-81 pubmed publisher
    ..critical amino acid residues have a similar function in other members of the Mononegavirales, we examined the Sendai virus (SeV) (family Paramyxoviridae) L protein by targeting homologous amino acid residues important for cap ..
  22. Le T, Mironova E, Garcin D, Compans R. Induction of influenza-specific mucosal immunity by an attenuated recombinant Sendai virus. PLoS ONE. 2011;6:e18780 pubmed publisher
    ..Here we report a novel recombinant, attenuated Sendai virus vector (GP42-H1) in which the hemagglutinin (HA) gene of influenza A virus was introduced into the Sendai virus ..
  23. Zeng W, Xu M, Liu S, Sun L, Chen Z. Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol Cell. 2009;36:315-25 pubmed publisher
    ..Furthermore, we show that replacement of endogenous ubiquitin with its K63R mutant abolishes viral activation of IRF3, demonstrating that K63 polyubiquitination plays a key role in IRF3 activation. ..
  24. Griesenbach U, Meng C, Farley R, Cheng S, Scheule R, Davies M, et al. In vivo imaging of gene transfer to the respiratory tract. Biomaterials. 2008;29:1533-40 pubmed
    ..correlate with standard tissue homogenate-based luciferase detection in a dose-dependent manner? Recombinant Sendai virus (SeV) transduces airway epithelial cells very efficiently and was used to address this question, (2) Is the ..
  25. Saha S, Pietras E, He J, Kang J, Liu S, Oganesyan G, et al. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 2006;25:3257-63 pubmed
    ..Thus, our findings suggest that the direct and specific interaction between the TRAF domain of TRAF3 and the TIM of Cardif is required for optimal Cardif-mediated antiviral responses. ..
  26. Nakanishi M, Otsu M. Development of Sendai virus vectors and their potential applications in gene therapy and regenerative medicine. Curr Gene Ther. 2012;12:410-6 pubmed
    ..Since its isolation in 1953 in Japan, Sendai virus (SeV) has been widely used as a research tool in cell biology and in industry, but the application of SeV as a ..
  27. Takeda A, Igarashi H, Kawada M, Tsukamoto T, Yamamoto H, Inoue M, et al. Evaluation of the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted Sendai virus vector-based vaccines in macaques. Vaccine. 2008;26:6839-43 pubmed publisher
    ..We previously showed the potential of recombinant Sendai virus (SeV) vectors to induce virus-specific T-cell responses in macaque AIDS models...
  28. Kohlmeier J, Miller S, Smith J, Lu B, Gerard C, Cookenham T, et al. The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity. 2008;29:101-13 pubmed publisher
    ..These data highlight the critical importance of early memory T cell recruitment for the efficacy of cellular immunity in the lung. ..
  29. Ye J, Maniatis T. Negative regulation of interferon-? gene expression during acute and persistent virus infections. PLoS ONE. 2011;6:e20681 pubmed publisher
    ..also show that the block to IFN? expression in mouse embryonic fibroblasts that are persistently infected with Sendai virus (SeV) correlates with the absence of transcriptionally active IRF3...
  30. Hermesh T, Moltedo B, Moran T, LOPEZ C. Antiviral instruction of bone marrow leukocytes during respiratory viral infections. Cell Host Microbe. 2010;7:343-53 pubmed publisher
    ..We show that, during infection with influenza or Sendai virus, the lung communicates with the sterile bone marrow, the primary site of hematopoiesis, through type I ..
  31. Kawaguchi Y, Miyamoto Y, Inoue T, Kaneda Y. Efficient eradication of hormone-resistant human prostate cancers by inactivated Sendai virus particle. Int J Cancer. 2009;124:2478-87 pubmed publisher
    ..Here, we examined the direct tumor-killing activity of inactivated Sendai virus particle [hemagglutinating virus of Japan envelope (HVJ-E)] through induction of Type I interferon (IFN) in the ..
  32. Shah N, Sunderland A, Grdzelishvili V. Cell type mediated resistance of vesicular stomatitis virus and Sendai virus to ribavirin. PLoS ONE. 2010;5:e11265 pubmed publisher
    ..against two nonsegmented negative-strand RNA viruses, vesicular stomatitis virus (VSV, a rhabdovirus) and Sendai virus (SeV, a paramyxovirus)...
  33. Morodomi Y, Yano T, Kinoh H, Harada Y, Saito S, Kyuragi R, et al. BioKnife, a uPA activity-dependent oncolytic Sendai virus, eliminates pleural spread of malignant mesothelioma via simultaneous stimulation of uPA expression. Mol Ther. 2012;20:769-77 pubmed publisher
    ..We here examined the potential of our new and powerful recombinant Sendai virus (rSeV), which shows uPAR-specific cell-to-cell fusion activity (rSeV/dMFct14 (uPA2), named "BioKnife")..
  34. Burke C, Mason J, Surman S, Jones B, Dalloneau E, Hurwitz J, et al. Illumination of parainfluenza virus infection and transmission in living animals reveals a tissue-specific dichotomy. PLoS Pathog. 2011;7:e1002134 pubmed publisher
    ..Here we used bioluminescence imaging to visualize the spatial and temporal progression of murine PIV1 (Sendai virus) infection in living mice after intranasal inoculation or exposure by contact...
  35. Dou J, Chen L, Xu G, Zhang L, Zhou H, Wang H, et al. Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin-neuraminidase. Arch Virol. 2011;156:793-801 pubmed publisher
    ..However, there are no clinical drugs to control the infection caused by these viruses. Sendai virus (SeV) belongs to the family Paramyxoviridae and causes fatal pneumonia in mice, its natural host...
  36. Rudraraju R, Surman S, Jones B, Sealy R, Woodland D, Hurwitz J. Phenotypes and functions of persistent Sendai virus-induced antibody forming cells and CD8+ T cells in diffuse nasal-associated lymphoid tissue typify lymphocyte responses of the gut. Virology. 2011;410:429-436 pubmed publisher
    ..n.) vaccinations or infections. Here we evaluate an i.n. inoculation with Sendai virus (SeV) for elicitation of virus-specific antibody forming cells (AFCs) and CD8(+) T cells in the d-NALT...
  37. Brown S, Hurwitz J, Zirkel A, Surman S, Takimoto T, Alymova I, et al. A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein. J Virol. 2007;81:12535-42 pubmed
    ..Here we describe a recombinant Sendai virus strategy for probing the effector role(s) of CD4(+) T cells...
  38. Hurwitz J. Development of recombinant Sendai virus vaccines for prevention of human parainfluenza and respiratory syncytial virus infections. Pediatr Infect Dis J. 2008;27:S126-8 pubmed publisher
    ..Researchers at St. Jude Children's Research Hospital are now developing Sendai virus (SV), a natural respiratory pathogen of mice, as a Jennerian vaccine for hPIV-1, and as a vaccine backbone for ..
  39. Kato T, Ueda Y, Kinoh H, Yoneyama Y, Matsunaga A, Komaru A, et al. RIG-I helicase-independent pathway in sendai virus-activated dendritic cells is critical for preventing lung metastasis of AT6.3 prostate cancer. Neoplasia. 2010;12:906-14 pubmed
    ..These results indicate the essential role of RIG-I-independent signaling on antimetastatic effect induced by rSeV-activated DCs and may provide important insights to DC-based immunotherapy for advanced malignancies. ..
  40. Duan X, Yonemitsu Y, Chou B, Yoshida K, Tanaka S, Hasegawa M, et al. Efficient protective immunity against Trypanosoma cruzi infection after nasal vaccination with recombinant Sendai virus vector expressing amastigote surface protein-2. Vaccine. 2009;27:6154-9 pubmed publisher
    ..Taking together, the current findings indicate that recombinant Sendai virus expressing the ASP2 or UASP2 antigens of T...
  41. Ryzhakov G, Randow F. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J. 2007;26:3180-90 pubmed
    ..SINTBAD constitutively binds TBK1 and IKKi but not related kinases. Upon infection with Sendai virus, SINTBAD is essential for the efficient induction of IRF-dependent transcription, as are two further TBK1 ..
  42. Sealy R, Jones B, Surman S, Hurwitz J. Robust IgA and IgG-producing antibody forming cells in the diffuse-NALT and lungs of Sendai virus-vaccinated cotton rats associate with rapid protection against human parainfluenza virus-type 1. Vaccine. 2010;28:6749-56 pubmed publisher
    b>Sendai virus (SeV), a natural mouse pathogen, shows considerable promise as a candidate vaccine for human parainfluenza virus-type 1 (hPIV-1), and also as a vaccine vector for other serious pathogens of infants including respiratory ..
  43. Chattopadhyay S, Fensterl V, Zhang Y, Veleeparambil M, Yamashita M, Sen G. Role of interferon regulatory factor 3-mediated apoptosis in the establishment and maintenance of persistent infection by Sendai virus. J Virol. 2013;87:16-24 pubmed publisher
    ..When IRF-3-knockdown cells were infected with Sendai virus (SeV), persistent infection (PI) was established...
  44. Martínez Gil L, Goff P, Hai R, Garcia Sastre A, Shaw M, Palese P. A Sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant. J Virol. 2013;87:1290-300 pubmed publisher
    ..One of the best-characterized natural RIG-I agonists is the defective interfering (DI) RNA produced by Sendai virus strain Cantell...
  45. Mima H, Yamamoto S, Ito M, Tomoshige R, Tabata Y, Tamai K, et al. Targeted chemotherapy against intraperitoneally disseminated colon carcinoma using a cationized gelatin-conjugated HVJ envelope vector. Mol Cancer Ther. 2006;5:1021-8 pubmed
    The hemagglutinating virus of Japan envelope (HVJ-E; Sendai virus) vector derived from inactivated HVJ particles can be used to deliver DNA, proteins, and drugs into cells both in vitro and in vivo...
  46. Irie T, Kiyotani K, Igarashi T, Yoshida A, Sakaguchi T. Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein. J Virol. 2012;86:7136-45 pubmed publisher
    The V protein of Sendai virus (SeV) suppresses innate immunity, resulting in enhancement of viral growth in mouse lungs and viral pathogenicity...
  47. Gosselin Grenet A, Mottet Osman G, Roux L. From assembly to virus particle budding: pertinence of the detergent resistant membranes. Virology. 2006;344:296-303 pubmed
    Detergent resistant membranes (DRMs) are the site of assembly for a variety of viruses. Here, we make use of Sendai virus mutant proteins that are not packaged into virus particles to determine the involvement of this assembly for the ..
  48. Bampi C, Rasga L, Roux L. Antagonism to human BST-2/tetherin by Sendai virus glycoproteins. J Gen Virol. 2013;94:1211-9 pubmed publisher
    Tetherin is an interferon-inducible factor that restricts viral particle production. We show here that Sendai virus (SeV) induces a drastic decrease in tetherin levels in infected HeLa cells...
  49. Zhan X, Hurwitz J, Krishnamurthy S, Takimoto T, Boyd K, Scroggs R, et al. Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B. Vaccine. 2007;25:8782-93 pubmed
    ..rSV-RSV-F), created by the recombination of an RSV F sequence with the murine parainfluenza virus-type 1 (Sendai virus, SV) genome...
  50. Strahle L, Marq J, Brini A, Hausmann S, Kolakofsky D, Garcin D. Activation of the beta interferon promoter by unnatural Sendai virus infection requires RIG-I and is inhibited by viral C proteins. J Virol. 2007;81:12227-37 pubmed
    As infection with wild-type (wt) Sendai virus (SeV) normally activates beta interferon (IFN-beta) very poorly, two unnatural SeV infections were used to study virus-induced IFN-beta activation in mouse embryonic fibroblasts: (i) SeV-DI-H4,..
  51. Ban H, Inoue M, Griesenbach U, Munkonge F, Chan M, Iida A, et al. Expression and maturation of Sendai virus vector-derived CFTR protein: functional and biochemical evidence using a GFP-CFTR fusion protein. Gene Ther. 2007;14:1688-94 pubmed
    b>Sendai virus (SeV) vector has been shown to efficiently transduce airway epithelial cells...
  52. Takimoto T, Hurwitz J, Zhan X, Krishnamurthy S, Prouser C, Brown B, et al. Recombinant Sendai virus as a novel vaccine candidate for respiratory syncytial virus. Viral Immunol. 2005;18:255-66 pubmed
    ..disease severity; considers the history of RSV vaccine development; and advocates the potential utility of Sendai virus (a murine paramyxovirus) as a xenogenic vaccine vector for the delivery of RSV antigens...
  53. Yu S, Feng X, Shu T, Matano T, Hasegawa M, Wang X, et al. Potent specific immune responses induced by prime-boost-boost strategies based on DNA, adenovirus, and Sendai virus vectors expressing gag gene of Chinese HIV-1 subtype B. Vaccine. 2008;26:6124-31 pubmed publisher
    ..HIV-1 strains in China, we have examined the potency of vaccine regimens of plasmid DNA, adenovirus, and Sendai virus vectors expressing HIV-1 gag consensus sequence of HIV-1 isolates from China for inducing specific immune ..
  54. Hirayama E, Hattori M, Kim J. Specific binding of heat shock protein 70 with HN-protein inhibits the HN-protein assembly in Sendai virus-infected Vero cells. Virus Res. 2006;120:199-207 pubmed
    The production of hemagglutinating virus of Japan (HVJ; Sendai virus) was inhibited at 41 degrees C, whereas it was normal at 37 degrees C...
  55. Hausmann S, Marq J, Tapparel C, Kolakofsky D, Garcin D. RIG-I and dsRNA-induced IFNbeta activation. PLoS ONE. 2008;3:e3965 pubmed publisher
    ..e., poly-I/C has the unique ability to stimulate the helicase ATPase of RIG-I variants which lack the C-terminal regulatory domain. ..
  56. Jones B, Zhan X, Mishin V, Slobod K, Surman S, Russell C, et al. Human PIV-2 recombinant Sendai virus (rSeV) elicits durable immunity and combines with two additional rSeVs to protect against hPIV-1, hPIV-2, hPIV-3, and RSV. Vaccine. 2009;27:1848-57 pubmed publisher
    ..Two new Sendai virus (SeV)-based hPIV-2 vaccine constructs were generated by inserting the fusion (F) gene or the hemagglutinin-..
  57. Zhang Q, Yuan W, Zhai G, Zhu S, Xue Z, Zhu H, et al. Inactivated Sendai virus suppresses murine melanoma growth by inducing host immune responses and down-regulating ?-catenin expression. Biomed Environ Sci. 2012;25:509-16 pubmed publisher
    This paper aims to investigate the anti-tumor mechanism of inactivated Sendai virus (Hemagglutinating virus of Japan envelope, HVJ-E) for murine melanoma (B16F10)...
  58. Hikono H, Miyazaki A, Mase M, Inoue M, Hasegawa M, Saito T. Induction of a cross-reactive antibody response to influenza virus M2 antigen in pigs by using a Sendai virus vector. Vet Immunol Immunopathol. 2012;146:92-6 pubmed publisher
    ..We tested whether a recombinant F gene-deleted Sendai virus vector that contained an M2 gene derived from an H5N1 avian influenza virus (SeV/ΔF/H5N1M2) could induce a ..
  59. Plattet P, Strahle L, le Mercier P, Hausmann S, Garcin D, Kolakofsky D. Sendai virus RNA polymerase scanning for mRNA start sites at gene junctions. Virology. 2007;362:411-20 pubmed
    Mini-genomes expressing two reporter genes and a variable gene junction were used to study Sendai virus RNA polymerase (RdRp) scanning for the mRNA start signal of the downstream gene (gs2)...
  60. Fink K, Duval A, Martel A, Soucy Faulkner A, Grandvaux N. Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells. J Immunol. 2008;180:6911-22 pubmed
    ..Similar results were obtained in the context of infection by Sendai virus, thus demonstrating that the newly identified NOX2-dependent NF-kappaB activation pathway is not restricted to ..
  61. Matsushima Miyagi T, Hatano K, Nomura M, Li Wen L, Nishikawa T, Saga K, et al. TRAIL and Noxa are selectively upregulated in prostate cancer cells downstream of the RIG-I/MAVS signaling pathway by nonreplicating Sendai virus particles. Clin Cancer Res. 2012;18:6271-83 pubmed publisher
    ..However, a replication-incompetent hemagglutinating virus of Japan (HVJ; Sendai virus) envelope (HVJ-E) suppresses the growth of human cancer cells as effectively as replication-competent live HVJ ..
  62. Kawashita Y, Fujioka H, Ohtsuru A, Kaneda Y, Kamohara Y, Kawazoe Y, et al. The efficacy and safety of gene transfer into the porcine liver in vivo by HVJ (Sendai virus) liposome. Transplantation. 2005;80:1623-9 pubmed
    ..HVJ-liposome vector is a hybrid vector consisting of liposome and an inactivated Sendai virus (Hemmagglutinating Virus of Japan [HVJ]), which has been reported to be less immunogenic and can also be ..
  63. Zhan X, Slobod K, Krishnamurthy S, Luque L, Takimoto T, Jones B, et al. Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections. Vaccine. 2008;26:3480-8 pubmed publisher
    ..Here we describe the testing of hPIV-3 and RSV candidate vaccines using Sendai virus (SeV, murine PIV-1) as a vector...
  64. Le T, Kawachi M, Yamada H, Shiota M, Okumura Y, Kido H. Identification of trypsin I as a candidate for influenza A virus and Sendai virus envelope glycoprotein processing protease in rat brain. Biol Chem. 2006;387:467-75 pubmed
    ..trypsin-like proteases is a prerequisite for the infectivity and pathogenicity of human influenza A viruses and Sendai virus. The common epidemic influenza A viruses are pneumotropic, but occasionally cause encephalopathy or ..
  65. Simon A, Sasaki N, Ichii O, Kajino K, Kon Y, Agui T. Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice. Microbes Infect. 2011;13:783-97 pubmed publisher characterize the key roles of cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in resistant C57BL/6J and susceptible DBA/2J mice...
  66. Saga K, Tamai K, Kawachi M, Shimbo T, Fujita H, Yamazaki T, et al. Functional modification of Sendai virus by siRNA. J Biotechnol. 2008;133:386-94 pubmed
    b>Sendai virus (hemagglutinating virus of Japan; HVJ) is a negative-strand RNA virus with robust fusion activity, and has been utilized for gene transfer and drug delivery...
  67. Tanaka M, Shimbo T, Kikuchi Y, Matsuda M, Kaneda Y. Sterile alpha motif containing domain 9 is involved in death signaling of malignant glioma treated with inactivated Sendai virus particle (HVJ-E) or type I interferon. Int J Cancer. 2010;126:1982-1991 pubmed publisher
    ..We found that inactivated Sendai virus particle (HVJ-E) induced extensive cell death in the human glioblastoma cell line U251MG...
  68. Faisca P, Desmecht D. Sendai virus, the mouse parainfluenza type 1: a longstanding pathogen that remains up-to-date. Res Vet Sci. 2007;82:115-25 pubmed
    Biologically speaking, Sendai virus (SeV), the murine parainfluenza virus type 1, is perceived as a common respiratory pathogen that is endemic in many rodent colonies throughout the world...
  69. Diao F, Li S, Tian Y, Zhang M, Xu L, Zhang Y, et al. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. Proc Natl Acad Sci U S A. 2007;104:11706-11 pubmed
    ..These findings suggest that DAK is a physiological suppressor of MDA5 and specifically inhibits MDA5- but not RIG-I-mediated innate antiviral signaling. ..
  70. Gosselin Grenet A, Mottet Osman G, Roux L. Sendai virus particle production: basic requirements and role of the SYWST motif present in HN cytoplasmic tail. Virology. 2010;405:439-47 pubmed publisher
    b>Sendai virus (SeV) HN protein is dispensable for virus particle production. HN incorporation into virions strictly depends on a cytoplasmic domain SYWST motif...
  71. Kato A, Kiyotani K, Kubota T, Yoshida T, Tashiro M, Nagai Y. Importance of the anti-interferon capacity of Sendai virus C protein for pathogenicity in mice. J Virol. 2007;81:3264-71 pubmed
    The Sendai virus (SeV) C protein blocks signal transduction of interferon (IFN), thereby counteracting the antiviral actions of IFN...
  72. Bibeau Poirier A, Gravel S, Clément J, Rolland S, Rodier G, Coulombe P, et al. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J Immunol. 2006;177:5059-67 pubmed
    ..In this study, we show that polyubiquitination of IRF-3 increases in response to Sendai virus infection...
  73. Irie T, Shimazu Y, Yoshida T, Sakaguchi T. The YLDL sequence within Sendai virus M protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein. J Virol. 2007;81:2263-73 pubmed publisher
    ..Here we show that both Sendai virus (SeV) matrix protein M and accessory protein C contribute to virus budding by physically interacting with Alix/..
  74. Gosselin Grenet A, Marq J, Abrami L, Garcin D, Roux L. Sendai virus budding in the course of an infection does not require Alix and VPS4A host factors. Virology. 2007;365:101-12 pubmed
    Closing the Sendai virus C protein open reading frames (rSeV-DeltaC virus) results in the production of virus particles with highly reduced infectivity...
  75. Corral T, Ver L, Mottet G, Cano O, García Barreno B, Calder L, et al. High level expression of soluble glycoproteins in the allantoic fluid of embryonated chicken eggs using a Sendai virus minigenome system. BMC Biotechnol. 2007;7:17 pubmed
    ..We now describe a system, based on a Sendai virus minigenome, to produce large amounts of heterologous viral glycoproteins in the allantoic cavity of embryonated ..
  76. Komaru A, Ueda Y, Furuya A, Tanaka S, Yoshida K, Kato T, et al. Sustained and NK/CD4+ T cell-dependent efficient prevention of lung metastasis induced by dendritic cells harboring recombinant Sendai virus. J Immunol. 2009;183:4211-9 pubmed publisher
  77. Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, et al. Evaluation of a novel vaccine (HVJ-liposome/HSP65 DNA+IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB. Vaccine. 2007;25:2990-3 pubmed
    ..These data indicate that our novel DNA vaccine might be useful against Mycobacterium tuberculosis for human clinical trials. ..
  78. Nomura M, Shimbo T, Miyamoto Y, Fukuzawa M, Kaneda Y. 13-Cis retinoic acid can enhance the antitumor activity of non-replicating Sendai virus particle against neuroblastoma. Cancer Sci. 2013;104:238-44 pubmed publisher
    Hemagglutinating virus of Japan-envelope (HVJ-E) is a drug delivery vector based on inactivated Sendai virus. Recently, antitumor activities were found for HVJ-E itself and clinical trials of HVJ-E for some malignant tumors are now ..
  79. Yang K, Shi H, Qi R, Sun S, Tang Y, Zhang B, et al. Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell. 2006;17:1461-71 pubmed
    ..genes and abolishes the cytoplasm-to-nucleus translocation and DNA binding activity of IRF3 in Sendai virus-infected cells...
  80. Villenave R, Touzelet O, Thavagnanam S, Sarlang S, Parker J, Skibinski G, et al. Cytopathogenesis of Sendai virus in well-differentiated primary pediatric bronchial epithelial cells. J Virol. 2010;84:11718-28 pubmed publisher
    b>Sendai virus (SeV) is a murine respiratory virus of considerable interest as a gene therapy or vaccine vector, as it is considered nonpathogenic in humans. However, little is known about its interaction with the human respiratory tract...
  81. Okano S, Yonemitsu Y, Shirabe K, Kakeji Y, Maehara Y, Harada M, et al. Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus. J Immunol. 2011;186:1828-39 pubmed publisher
    ..DC stimulated via cytokine receptors, or TLRs, do not show these functional features. Therefore, SeV-infected DC have the potential for DC-directed immunotherapy. ..
  82. Shimazu Y, Takao S, Irie T, Kiyotani K, Yoshida T, Sakaguchi T. Contribution of the leader sequence to homologous viral interference among Sendai virus strains. Virology. 2008;372:64-71 pubmed
    ..These results indicate that homologous interference is partly dependent on the promoter sequence and further suggest involvement of promoter activity for genome amplification related to host factors in viral interference. ..
  83. Melchjorsen J, Jensen S, Malmgaard L, Rasmussen S, Weber F, Bowie A, et al. Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner. J Virol. 2005;79:12944-51 pubmed
    ..Here we show that activation of signal transduction and induction of cytokine expression by the paramyxovirus Sendai virus is dependent on virus replication and involves PRRs in a cell-type-dependent manner...
  84. Griesenbach U, Inoue M, Hasegawa M, Alton E. Sendai virus for gene therapy and vaccination. Curr Opin Mol Ther. 2005;7:346-52 pubmed
    b>Sendai virus (SeV), also known as hemagglutinating virus of Japan (HVJ), is a negative-strand RNA virus and a member of the paramyxovirus family...
  85. Loney C, Mottet Osman G, Roux L, Bhella D. Paramyxovirus ultrastructure and genome packaging: cryo-electron tomography of sendai virus. J Virol. 2009;83:8191-7 pubmed publisher
    ..We conducted a low-resolution ultrastructural analysis of Sendai virus, a prototype paramyxovirus, using cryo-electron tomography...
  86. Yukawa H, Noguchi H, Oishi K, Miyazaki T, Kitagawa Y, Inoue M, et al. Recombinant sendai virus-mediated gene transfer to adipose tissue-derived stem cells (ASCs). Cell Transplant. 2008;17:43-50 pubmed
    ..However, the use of gene transfer with Sendai virus (SeV) vectors, which can efficiently introduce foreign genes without toxicity into several cells, with ASCs has ..
  87. Jones B, Sealy R, Rudraraju R, Traina Dorge V, Finneyfrock B, Cook A, et al. Sendai virus-based RSV vaccine protects African green monkeys from RSV infection. Vaccine. 2012;30:959-68 pubmed publisher
    ..b>Sendai virus (SeV) is a mouse parainfluenza virus-type 1 which has been previously shown to confer protection against its ..
  88. Takeuchi K, Komatsu T, Kitagawa Y, Sada K, Gotoh B. Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA. J Virol. 2008;82:10102-10 pubmed publisher
    b>Sendai virus (SeV) C protein is a multifunctional protein that plays important roles in regulating viral genome replication and transcription, antagonizing the host interferon system, suppressing virus-induced apoptosis, and facilitating ..
  89. Zhong B, Yang Y, Li S, Wang Y, Li Y, Diao F, et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity. 2008;29:538-50 pubmed publisher
    ..Our results suggest that MITA is a critical mediator of virus-triggered IRF3 activation and IFN expression and further demonstrate the importance of certain mitochondrial proteins in innate antiviral immunity. ..
  90. Gunsten S, Mikols C, Grayson M, Schwendener R, Agapov E, Tidwell R, et al. IL-12 p80-dependent macrophage recruitment primes the host for increased survival following a lethal respiratory viral infection. Immunology. 2009;126:500-13 pubmed publisher
    ..Following infection with a sublethal dose of mouse parainfluenza virus type 1 (Sendai virus), the transgenic mice demonstrated an earlier peak and decline in the number of airway inflammatory cells...
  91. Lei C, Zhong B, Zhang Y, Zhang J, Wang S, Shu H. Glycogen synthase kinase 3? regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity. 2010;33:878-89 pubmed publisher
    ..Our findings suggest that GSK3? plays important roles in virus-triggered IRF3 activation by promoting TBK1 activation and provide new insights to the molecular mechanisms of cellular antiviral response...