phocine distemper virus

Summary

Summary: A species of MORBILLIVIRUS causing distemper in seals.

Top Publications

  1. Seibel H, Baumgartner W, Muller G, Wohlsein P, Siebert U. [Retrospective analysis of two phocine distemper epidemics in the North and Baltic Seas in 1988 and 2002]. Dtsch Tierarztl Wochenschr. 2007;114:284-93 pubmed
    The relapse of the outbreak of the phocine distemper virus in the Danish island of Anholt this June, emphasizes the importance of the topic among experts...
  2. Rijks J, van de Bildt M, Jensen T, Philippa J, Osterhaus A, Kuiken T. Phocine distemper outbreak, The Netherlands, 2002. Emerg Infect Dis. 2005;11:1945-8 pubmed
    ..Stranding pattern varied with age, sex, state of decomposition, wind, and location. Cumulative proportion of deaths (54%) was comparable to that in the first reported epidemic in 1988...
  3. Duignan P, Saliki J, St Aubin D, House J, Geraci J. Neutralizing antibodies to phocine distemper virus in Atlantic walruses (Odobenus rosmarus rosmarus) from Arctic Canada. J Wildl Dis. 1994;30:90-4 pubmed
    The first evidence of phocine distemper virus (PDV) infection in Atlantic walruses (Odobenus rosmarus rosmarus) from Nottingham Island, Northwest Territories, Canada, is reported...
  4. Zarnke R, Saliki J, Macmillan A, Brew S, Dawson C, Ver Hoef J, et al. Serologic survey for Brucella spp., phocid herpesvirus-1, phocid herpesvirus-2, and phocine distemper virus in harbor seals from Alaska, 1976-1999. J Wildl Dis. 2006;42:290-300 pubmed
    ..phocid herpesvirus-1 (PhoHV-1), phocid herpesvirus-2 (PhHV-2), and phocine distemper virus (PDV). Antibody prevalence rates were 46% (46/100) for Brucella spp...
  5. Goldstein T, Mazet J, Gill V, Doroff A, Burek K, Hammond J. Phocine distemper virus in northern sea otters in the Pacific Ocean, Alaska, USA. Emerg Infect Dis. 2009;15:925-7 pubmed publisher
    b>Phocine distemper virus (PDV) has caused 2 epidemics in harbor seals in the Atlantic Ocean but had never been identified in any Pacific Ocean species...
  6. Blixenkrone Møller M. Biological properties of phocine distemper virus and canine distemper virus. APMIS Suppl. 1993;36:1-51 pubmed
    ..in the Paramyxoviridae family comprises five established members, namely canine distemper virus (CDV), phocine distemper virus (PDV), measles virus (MV), rinderpest virus (RPV), and peste-des-petits-ruminants virus (PPRV)...
  7. Wohlsein P, Muller G, Haas L, Siebert U, Harder T, Baumgartner W. Antigenic characterization of phocine distemper virus causing mass mortality in 2002 and its relationship to other morbilliviruses. Arch Virol. 2007;152:1559-64 pubmed
    The antigenic relationship between the phocine distemper virus (PDV) strain causing the epidemic in 2002 and the PDV strain of 1988, canine distemper virus from two dogs and one marten, and one measles virus strain was investigated in ..
  8. Harkonen T, Dietz R, Reijnders P, Teilmann J, Harding K, Hall A, et al. The 1988 and 2002 phocine distemper virus epidemics in European harbour seals. Dis Aquat Organ. 2006;68:115-30 pubmed
    We present new and revised data for the phocine distemper virus (PDV) epidemics that resulted in the deaths of more than 23 000 harbour seals Phoca vitulina in 1988 and 30,000 in 2002...
  9. Hammond J, Pomeroy P, Hall A, Smith V. Identification and real-time PCR quantification of Phocine distemper virus from two colonies of Scottish grey seals in 2002. J Gen Virol. 2005;86:2563-7 pubmed
    The North Sea European harbour seal (Phoca vitulina) population has endured two phocine distemper virus (PDV) epidemics in 1988 and 2002...

More Information

Publications56

  1. Duignan P, Nielsen O, House C, Kovacs K, Duffy N, Early G, et al. Epizootiology of morbillivirus infection in harp, hooded, and ringed seals from the Canadian Arctic and western Atlantic. J Wildl Dis. 1997;33:7-19 pubmed
    Using a virus neutralization technique, we found phocine distemper virus (PDV) antibody in 130 (83% of 157) harp seals (Phoca groenlandica) from the western North Atlantic sampled between 1988 and 1993 inclusive...
  2. Müller G, Wohlsein P, Beineke A, Haas L, Greiser Wilke I, Siebert U, et al. Phocine distemper in German seals, 2002. Emerg Infect Dis. 2004;10:723-5 pubmed
    Approximately 21,700 seals died during a morbillivirus epidemic in northwestern Europe in 2002. Phocine distemper virus 1 was isolated from seals in German waters...
  3. Jensen T, van de Bildt M, Dietz H, Andersen T, Hammer A, Kuiken T, et al. Another phocine distemper outbreak in Europe. Science. 2002;297:209 pubmed
  4. de Koeijer A, Diekmann O, Reijnders P. Modelling the spread of phocine distemper virus among harbour seals. Bull Math Biol. 1998;60:585-96 pubmed
    ..However, especially for diseases with a low R0 and high death rates, such as the phocine distemper virus (PDV) disease, the two model formulations give quite different results...
  5. Stimmer L, Siebert U, Wohlsein P, Fontaine J, Baumgartner W, Beineke A. Viral protein expression and phenotyping of inflammatory responses in the central nervous system of phocine distemper virus-infected harbor seals (Phoca vitulina). Vet Microbiol. 2010;145:23-33 pubmed publisher
    The central nervous system (CNS) represents an important target organ of the phocine distemper virus (PDV)...
  6. Bogomolni A, Frasca S, Levin M, Matassa K, Nielsen O, Waring G, et al. In Vitro Exposure of Harbor Seal Immune Cells to Aroclor 1260 Alters Phocine Distemper Virus Replication. Arch Environ Contam Toxicol. 2016;70:121-32 pubmed publisher
    ..harbor seal T-lymphocyte proliferation and to assess if exposure resulted in increased likelihood of phocine distemper virus (PDV USA 2006) to infect susceptible seals in an in vitro system...
  7. Stanton J, Brown C, Poet S, Lipscomb T, Saliki J, Frasca S. Retrospective differentiation of canine distemper virus and phocine distemper virus in phocids. J Wildl Dis. 2004;40:53-9 pubmed
    ..polymerase chain reaction (RT-PCR) to detect and differentiate canine distemper virus (CDV) and phocine distemper virus (PDV). Four antibodies made against PDV were able to detect both viruses...
  8. Liu F, Wu X, Li L, Zou Y, Liu S, Wang Z. Evolutionary characteristics of morbilliviruses during serial passages in vitro: Gradual attenuation of virus virulence. Comp Immunol Microbiol Infect Dis. 2016;47:7-18 pubmed publisher
    ..MV), rinderpest virus (RPV), peste-des-petits-ruminants virus (PPRV), canine distemper virus (CDV), phocine distemper virus (PDV) and cetacean morbillivirus (CeMV)...
  9. Rungelrath V, Wohlsein J, Siebert U, Stott J, Prenger Berninghoff E, von Pawel Rammingen U, et al. Identification of a novel host-specific IgG protease in Streptococcus phocae subsp. phocae. Vet Microbiol. 2017;201:42-48 pubmed publisher
    ..Especially in harbor seals infected with phocine distemper virus it plays an important role as an opportunistic pathogen...
  10. Bogomolni A, Bass A, Fire S, Jasperse L, Levin M, Nielsen O, et al. Saxitoxin increases phocine distemper virus replication upon in-vitro infection in harbor seal immune cells. Harmful Algae. 2016;51:89-96 pubmed publisher
    ..In two of three saxitoxin (STX) associated mortality events, dolphin morbillivirus (DMV) or phocine distemper virus (PDV) was isolated in affected individuals...
  11. Ludes Wehrmeister E, Dupke C, Harder T, Baumgärtner W, Haas L, Teilmann J, et al. Phocine distemper virus (PDV) seroprevalence as predictor for future outbreaks in harbour seals. Vet Microbiol. 2016;183:43-9 pubmed publisher
    b>Phocine distemper virus (PDV) infections caused the two most pronounced mass mortalities in marine mammals documented in the past century...
  12. Jo W, Osterhaus A, Ludlow M. Transmission of morbilliviruses within and among marine mammal species. Curr Opin Virol. 2018;28:133-141 pubmed publisher
    ..Cetacean morbillivirus spreads between cetacean species in the aquatic environment whereas both phocine distemper virus and canine distemper virus have been associated with transmission within and between pinniped and ..
  13. Muller G, Kaim U, Haas L, Greiser Wilke I, Wohlsein P, Siebert U, et al. Phocine distemper virus: characterization of the morbillivirus causing the seal epizootic in northwestern Europe in 2002. Arch Virol. 2008;153:951-6 pubmed publisher
  14. Woodman S, Gibson A, García A, Contreras G, Rossen J, Werling D, et al. Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals. Vet Immunol Immunopathol. 2016;169:10-4 pubmed publisher
    ..Indeed, viral pathogens such as influenza A virus and phocine distemper virus (PDV) have been identified as the cause of several of these mass mortality events...
  15. Kreutzer M, Kreutzer R, Siebert U, Muller G, Reijnders P, Brasseur S, et al. In search of virus carriers of the 1988 and 2002 phocine distemper virus outbreaks in European harbour seals. Arch Virol. 2008;153:187-92 pubmed
    European harbour seal (Phoca vitulina) populations decreased substantially during the phocine distemper virus (PDV) outbreaks of 1988 and 2002...
  16. Klepac P, Pomeroy L, Bjørnstad O, Kuiken T, Osterhaus A, Rijks J. Stage-structured transmission of phocine distemper virus in the Dutch 2002 outbreak. Proc Biol Sci. 2009;276:2469-76 pubmed publisher
    ..We investigate the importance of such stage-related heterogeneities in shaping the 2002 phocine distemper virus (PDV) outbreak in the Dutch Wadden Sea, when more than 40 per cent of the harbour seals were killed...
  17. Harris C, Travis J, Harwood J. Evaluating the influence of epidemiological parameters and host ecology on the spread of phocine distemper virus through populations of harbour seals. PLoS ONE. 2008;3:e2710 pubmed publisher
    Outbreaks of phocine distemper virus (PDV) in Europe during 1988 and 2002 were responsible for the death of around 23,000 and 30,000 harbour seals, respectively...
  18. Cosby S, Weir L. Measles vaccination: Threat from related veterinary viruses and need for continued vaccination post measles eradication. Hum Vaccin Immunother. 2017;: pubmed publisher
    ..peste des petits ruminants virus (PPRV), Rinderpest Virus (RPV) as well as the marine morbilliviruses phocine distemper virus (PDV), dolphin morbillivirus (DMV) and porpoise morbillivirus (PMV)...
  19. Nielsen O, Smith G, Weingartl H, Lair S, Measures L. Use of a SLAM transfected Vero cell line to isolate and characterize marine mammal morbilliviruses using an experimental ferret model. J Wildl Dis. 2008;44:600-11 pubmed
    Two ferrets (Mustela putorius furo) were experimentally infected with phocine distemper virus (PDV), from the 1988 seal epizootic in Europe, in order to determine whether the stable transfected Vero cell line (Vero...
  20. Hall A. Morbilliviruses in marine mammals. Trends Microbiol. 1995;3:4-9 pubmed
    ..Apparent differences between the dynamics of aquatic morbilliviruses and their terrestrial counterparts may be a consequence of high levels of interspecific transmission. ..
  21. Baumgartner W, Alldinger S, Beineke A, Gröters S, Herden C, Kaim U, et al. [Canine distemper virus--an agent looking for new hosts]. Dtsch Tierarztl Wochenschr. 2003;110:137-42 pubmed
    ..Different viruses have been isolated from pinnipeds including a seal-specific isolate, termed phocine distemper virus 1, PDV-1, and a CDV strain, named PDV-2...
  22. Philippa J, van de Bildt M, Kuiken T, t Hart P, Osterhaus A. Neurological signs in juvenile harbour seals (Phoca vitulina) with fatal phocine distemper. Vet Rec. 2009;164:327-31 pubmed
    In 2002, the northern European harbour seal (Phoca vitulina) population experienced an epidemic of phocine distemper virus (PDV) in which 22,000 seals died...
  23. Mamaev L, Denikina N, Belikov S, Volchkov V, Visser I, Fleming M, et al. Characterisation of morbilliviruses isolated from Lake Baikal seals (Phoca sibirica). Vet Microbiol. 1995;44:251-9 pubmed
    ..The virus continued to circulate in seals in Lake Baikal after the 1987/1988 epizootic since sera collected from culled seals in the spring of 1992 were positive in morbillivirus ELISA tests, reacting most strongly with the CDV antigen. ..
  24. Martens W, Greiser Wilke I, Harder T, Dittmar K, Frank R, Orvell C, et al. Spot synthesis of overlapping peptides on paper membrane supports enables the identification of linear monoclonal antibody binding determinants on morbillivirus phosphoproteins. Vet Microbiol. 1995;44:289-98 pubmed
    ..Fine mapping of this binding site revealed that this was a part of an antigenic domain. In Western blots, the monoclonal antibodies reacting with this domain also reacted with a second protein which was possibly the V-protein. ..
  25. Harding K, Hansen B, Goodman S. Acquired immunity and stochasticity in epidemic intervals impede the evolution of host disease resistance. Am Nat. 2005;166:722-30 pubmed
    ..general age-structured population genetic model was developed and parameterized using empirical data for phocine distemper virus (PDV) epizootics in harbor seals...
  26. Duignan P, Saliki J, St Aubin D, Early G, Sadove S, House J, et al. Epizootiology of morbillivirus infection in North American harbor seals (Phoca vitulina) and gray seals (Halichoerus grypus). J Wildl Dis. 1995;31:491-501 pubmed
    ..Infection may be maintained in the smaller harbor seal population through casual contact with gray seals. ..
  27. Nielsen L, Arctander P, Jensen T, Dietz H, Hammer A, Banyard A, et al. Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics. Virus Res. 2009;144:323-8 pubmed publisher
    ..Phylogenetic analysis of the H genes of phocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002 PDV is more closely related ..
  28. Olsson M, Karlsson B, Ahnland E. Diseases and environmental contaminants in seals from the Baltic and the Swedish west coast. Sci Total Environ. 1994;154:217-27 pubmed
    ..along the Swedish west coast and in the southwestern part of the Baltic died in the PDV epizootic (Phocine Distemper Virus). Whether the course of the epizootic was altered by environmental pollutants is still an open question...
  29. Duignan P, Duffy N, Rima B, Geraci J. Comparative antibody response in harbour and grey seals naturally infected by a morbillivirus. Vet Immunol Immunopathol. 1997;55:341-9 pubmed
    ..We speculate that this difference between the species may be an important determinant of morbillivirus susceptibility. ..
  30. Saliki J, Lehenbauer T. Monoclonal antibody-based competitive enzyme-linked immunosorbent assay for detection of morbillivirus antibody in marine mammal sera. J Clin Microbiol. 2001;39:1877-81 pubmed
    ..virus neutralization test (VNT) for detecting antibodies against canine distemper virus (CDV) and phocine distemper virus (PDV) in sera from dogs and various species of marine mammals...
  31. Rijks J, Read F, van de Bildt M, van Bolhuis H, Martina B, Wagenaar J, et al. Quantitative analysis of the 2002 phocine distemper epidemic in the Netherlands. Vet Pathol. 2008;45:516-30 pubmed publisher
    b>Phocine distemper virus (PDV) caused thousands of deaths among harbor seals (Phoca vitulina) from the North Sea in 1988 and 2002...
  32. Lonergan M, Hall A, Thompson H, Thompson P, Pomeroy P, Harwood J. Comparison of the 1988 and 2002 phocine distemper epizootics in British harbour seal Phoca vitulina populations. Dis Aquat Organ. 2010;88:183-8 pubmed publisher
    ..The large geographic variation in population effects observed within the UK during each epizootic appears to have been mainly due to differences in case mortality, with R0 being remarkably similar in all the populations investigated...
  33. Harkonen T, Harding K, Rasmussen T, Teilmann J, Dietz R. Age- and sex-specific mortality patterns in an emerging wildlife epidemic: the phocine distemper in European harbour seals. PLoS ONE. 2007;2:e887 pubmed
    ..The Phocine Distemper Virus (PDV) caused two mass mortalities in European harbour seals in 1988 and in 2002...
  34. Pohlmeyer G, Pohlenz J, Wohlsein P. Intestinal lesions in experimental phocine distemper: light microscopy, immunohistochemistry and electron microscopy. J Comp Pathol. 1993;109:57-69 pubmed
    ..Likewise, antigen of phocine distemper virus (PDV) was demonstrated immunohistochemically in the intestinal wall of all the seals...
  35. de Swart R, Harder T, Ross P, Vos H, Osterhaus A. Morbilliviruses and morbillivirus diseases of marine mammals. Infect Agents Dis. 1995;4:125-30 pubmed
    ..as causative agent of mass mortality among marine mammals was in 1988, when the previously unrecognized phocine distemper virus (PDV) caused the death of 20,000 harbor seals (Phoca vitulina) in northwestern Europe...
  36. Jauniaux T, Charlier G, Desmecht M, Haelters J, Jacques T, Losson B, et al. Pathological findings in two fin whales (Balaenoptera physalus) with evidence of morbillivirus infection. J Comp Pathol. 2000;123:198-201 pubmed
    ..To the authors> knowledge, this is the first firm report of morbillivirus infection in baleen whales...
  37. Akineden O, Hassan A, Alber J, El Sayed A, Estoepangestie A, Lammler C, et al. Phenotypic and genotypic properties of Streptococcus equi subsp. zooepidemicus isolated from harbor seals (Phoca vitulina) from the German North Sea during the phocine distemper outbreak in 2002. Vet Microbiol. 2005;110:147-52 pubmed
    ..These results indicate that a single bacterial clone seemed to be distributed among the harbor seal population of the German North Sea during this outbreak...
  38. McIlhatton M, Curran M, Rima B. Nucleotide sequence analysis of the large (L) genes of phocine distemper virus and canine distemper virus (corrected sequence). J Gen Virol. 1997;78 ( Pt 3):571-6 pubmed
    ..The sequence of the L gene of phocine distemper virus (PDV) was also determined...
  39. Clancy A, Crowley B, Niesters H, Herra C. The development of a qualitative real-time RT-PCR assay for the detection of hepatitis C virus. Eur J Clin Microbiol Infect Dis. 2008;27:1177-82 pubmed publisher
    ..A second heterologous probe assay was developed for the detection of the haemagglutinin gene of phocine distemper virus (PDV) and was used as an internal control...
  40. Fujii K, Sato H, Kakumoto C, Kobayashi M, Saito S, Kariya T, et al. Seroepidemiological survey of morbillivirus infection in Kuril harbor seals (Phoca vitulina stejnegeri) of Hokkaido, Japan. Jpn J Vet Res. 2006;54:109-17 pubmed
    ..Antibodies to phocine distemper virus (PDV) were detected by ELISA in seals from Nosappu and Erimo...
  41. Postnikov E, Sokolov I. Continuum description of a contact infection spread in a SIR model. Math Biosci. 2007;208:205-15 pubmed
    ..An explicit calculation is done for realistic values of parameters obtained from field epidemiological data for a phocine distemper virus infection among harbor seals in 1988.
  42. Van de Vijver K, Hoff P, Das K, Brasseur S, Van Dongen W, Esmans E, et al. Tissue distribution of perfluorinated chemicals in harbor seals (Phoca vitulina) from the Dutch Wadden Sea. Environ Sci Technol. 2005;39:6978-84 pubmed
    ..These data suggest large differences in tissue distribution and accumulation patterns of perfluorinated compounds in marine organisms. ..
  43. Cattet M, Duignan P, House C, Aubin D. Antibodies to canine distemper and phocine distemper viruses in polar bears from the Canadian arctic. J Wildl Dis. 2004;40:338-42 pubmed
    ..Differences in antibody prevalence to CDV were detected between populations and age classes but not sex or year of sampling. ..
  44. Barbour A, Kälin R. The duration of a sequence of epidemics. Bull Math Biol. 2003;65:397-405 pubmed
    ..Math. Biol., 60, 215-230]. This paper gives the sketch of a proof of the phenomenon...
  45. Ohashi K, Miyazaki N, Tanabe S, Nakata H, Miura R, Fujita K, et al. Seroepidemiological survey of distemper virus infection in the Caspian Sea and in Lake Baikal. Vet Microbiol. 2001;82:203-10 pubmed
    ..Virus neutralizing tests and ELISA clearly suggested that distemper virus epidemic was caused in Caspian seals before the spring of 1997 and that CDV infection continued to occur in Lake Baikal in recent years...
  46. Swinton J. Extinction times and phase transitions for spatially structured closed epidemics. Bull Math Biol. 1998;60:215-30 pubmed
    ..These expressions are compared with numerical results using parameters relevant to a study of phocine distemper virus in North Sea seals, and the agreement is found to be good for large and small N...
  47. Shimizu H, Shimizu C, Burns J. Detection of novel RNA viruses: morbilliviruses as a model system. Mol Cell Probes. 1994;8:209-14 pubmed
    ..from the nucleoprotein gene, which successfully amplified measles virus, canine distemper virus, and phocine distemper virus. In a single reaction which combines cDNA synthesis by reverse transcription of the RNA genome with the ..