measles virus

Summary

Summary: The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.

Top Publications

  1. de Vries R, Lemon K, Ludlow M, McQuaid S, Yüksel S, van Amerongen G, et al. In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaques. J Virol. 2010;84:4714-24 pubmed publisher
    ..The standard route of administration for the live-attenuated measles virus (MV) vaccine is subcutaneous injection, although alternative needle-free routes, including aerosol delivery, ..
  2. Bischak C, Longhi S, Snead D, Costanzo S, Terrer E, Londergan C. Probing structural transitions in the intrinsically disordered C-terminal domain of the measles virus nucleoprotein by vibrational spectroscopy of cyanylated cysteines. Biophys J. 2010;99:1676-83 pubmed publisher
    Four single-cysteine variants of the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (N(TAIL)) were cyanylated at cysteine and their infrared spectra in the C triple bond N stretching region were recorded ..
  3. Watanabe A, Yoneda M, Ikeda F, Sugai A, Sato H, Kai C. Peroxiredoxin 1 is required for efficient transcription and replication of measles virus. J Virol. 2011;85:2247-53 pubmed publisher
    Measles is a highly contagious human disease caused by the measles virus (MeV)...
  4. Ito M, Iwasaki M, Takeda M, Nakamura T, Yanagi Y, Ohno S. Measles virus nonstructural C protein modulates viral RNA polymerase activity by interacting with host protein SHCBP1. J Virol. 2013;87:9633-42 pubmed publisher
    Most viruses possess strategies to circumvent host immune responses. The measles virus (MV) nonstructural C protein suppresses the interferon response, thereby allowing efficient viral growth, but its detailed mechanism has been unknown...
  5. Shirogane Y, Takeda M, Tahara M, Ikegame S, Nakamura T, Yanagi Y. Epithelial-mesenchymal transition abolishes the susceptibility of polarized epithelial cell lines to measles virus. J Biol Chem. 2010;285:20882-90 pubmed publisher
    b>Measles virus (MV), an enveloped negative-strand RNA virus, remains a major cause of morbidity and mortality in developing countries...
  6. Frenzke M, Sawatsky B, Wong X, Delpeut S, Mateo M, Cattaneo R, et al. Nectin-4-dependent measles virus spread to the cynomolgus monkey tracheal epithelium: role of infected immune cells infiltrating the lamina propria. J Virol. 2013;87:2526-34 pubmed publisher
    After the contagion measles virus (MV) crosses the respiratory epithelium within myeloid cells that express the primary receptor signaling lymphocytic activation molecule (SLAM), it replicates briskly in SLAM-expressing cells in ..
  7. Xia M, Gonzalez P, Li C, Meng G, Jiang A, Wang H, et al. Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. J Virol. 2014;88:5152-64 pubmed publisher
    ..In particular, little is known about the role of autophagy in infection by attenuated measles virus of the Edmonston strain (MV-Edm)...
  8. Santiago C, Celma M, Stehle T, Casasnovas J. Structure of the measles virus hemagglutinin bound to the CD46 receptor. Nat Struct Mol Biol. 2010;17:124-9 pubmed publisher
    The highly contagious measles virus infects millions of individuals worldwide, causing serious disease in children of developing countries...
  9. Meng X, Nakamura T, Okazaki T, Inoue H, Takahashi A, Miyamoto S, et al. Enhanced antitumor effects of an engineered measles virus Edmonston strain expressing the wild-type N, P, L genes on human renal cell carcinoma. Mol Ther. 2010;18:544-51 pubmed publisher
    b>Measles virus Edmonston strain (MV-Edm) is thought to have remarkable oncolytic activity that selectively destroys human tumor cells. The P/V/C protein of wild-type MV was shown to resist the antiviral effects of interferon (IFN)-alpha...

More Information

Publications98

  1. Rota P, Brown K, Mankertz A, Santibanez S, Shulga S, Muller C, et al. Global distribution of measles genotypes and measles molecular epidemiology. J Infect Dis. 2011;204 Suppl 1:S514-23 pubmed publisher
    ..The future challenges will be to develop quality control programs for molecular methods and to continue to expand virologic surveillance activities in all regions. ..
  2. Plemper R, Brindley M, Iorio R. Structural and mechanistic studies of measles virus illuminate paramyxovirus entry. PLoS Pathog. 2011;7:e1002058 pubmed publisher
    b>Measles virus (MeV), a member of the paramyxovirus family of enveloped RNA viruses and one of the most infectious viral pathogens identified, accounts for major pediatric morbidity and mortality worldwide although coordinated efforts to ..
  3. Suspène R, Petit V, Puyraimond Zemmour D, Aynaud M, Henry M, Guetard D, et al. Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines. J Virol. 2011;85:2458-62 pubmed publisher
    ..editing of measles and influenza virus genomes derived from inactivated seasonal influenza and live attenuated measles virus vaccines grown on chicken cells as the culture substrate. Using highly sensitive 3DI-PCR (R. Suspène et al...
  4. Tahara M, Ito Y, Brindley M, Ma X, He J, Xu S, et al. Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein. J Virol. 2013;87:666-75 pubmed publisher
    ..eradication is biologically feasible, a structural and biochemical basis for the single serotype nature of measles virus (MV) remains to be provided...
  5. Lech P, Russell S. Use of attenuated paramyxoviruses for cancer therapy. Expert Rev Vaccines. 2010;9:1275-302 pubmed publisher
    Paramyxoviruses, measles virus (MV), mumps virus (MuV) and Newcastle disease virus (NDV), are well known for causing measles and mumps in humans and Newcastle disease in birds...
  6. Kurihara N, Hiruma Y, Yamana K, Michou L, Rousseau C, Morissette J, et al. Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease. Cell Metab. 2011;13:23-34 pubmed publisher
    ..Because measles virus nucleocapsid gene (MVNP) and the p62(P392L) mutation are implicated in PD, marrows from 12 PD patients ..
  7. Wakimoto H, Shimodo M, Satoh Y, Kitagawa Y, Takeuchi K, Gotoh B, et al. F-actin modulates measles virus cell-cell fusion and assembly by altering the interaction between the matrix protein and the cytoplasmic tail of hemagglutinin. J Virol. 2013;87:1974-84 pubmed publisher
    Actin filament (F-actin) is believed to be involved in measles virus (MV) assembly as a cellular factor, but the precise roles remain unknown...
  8. Opyrchal M, Allen C, Iankov I, Aderca I, Schroeder M, Sarkaria J, et al. Effective radiovirotherapy for malignant gliomas by using oncolytic measles virus strains encoding the sodium iodide symporter (MV-NIS). Hum Gene Ther. 2012;23:419-27 pubmed publisher
    Engineered measles virus (MV) strains deriving from the vaccine lineage represent a promising oncolytic platform and are currently being tested in phase I trials...
  9. Ji Y, Xu S, Zhang Y, Zhu Z, Mao N, Jiang X, et al. Genetic characterization of wild-type measles viruses isolated in China, 2006-2007. Virol J. 2010;7:105 pubmed publisher
  10. Jensen M, Communie G, Ribeiro E, Martinez N, Desfosses A, Salmon L, et al. Intrinsic disorder in measles virus nucleocapsids. Proc Natl Acad Sci U S A. 2011;108:9839-44 pubmed publisher
    The genome of measles virus is encapsidated by multiple copies of the nucleoprotein (N), forming helical nucleocapsids of molecular mass approaching 150 Megadalton...
  11. Sparrer K, Pfaller C, Conzelmann K. Measles virus C protein interferes with Beta interferon transcription in the nucleus. J Virol. 2012;86:796-805 pubmed publisher
    ..Infection of cells by paramyxoviruses, like measles virus (MV) (genus Morbillivirus), is sensed predominantly by the ubiquitous cytoplasmic helicase RIG-I, recognizing ..
  12. Stubblefield Park S, Widness M, Levine A, Patterson C. T cell-, interleukin-12-, and gamma interferon-driven viral clearance in measles virus-infected brain tissue. J Virol. 2011;85:3664-76 pubmed publisher
    ..with immunocompetent mice show the importance of both T cells and gamma interferon (IFN-?) for survival of a measles virus (MV) challenge; however, the direct role of T cells and IFN-? within the MV-infected brain has not been ..
  13. Chuprin A, Gal H, Biron Shental T, Biran A, Amiel A, Rozenblatt S, et al. Cell fusion induced by ERVWE1 or measles virus causes cellular senescence. Genes Dev. 2013;27:2356-66 pubmed publisher
    ..Infection by the measles virus, which leads to cell fusion, also induced cellular senescence in normal and cancer cells...
  14. Takaki H, Watanabe Y, Shingai M, Oshiumi H, Matsumoto M, Seya T. Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-?-inducing potential. Mol Immunol. 2011;48:497-504 pubmed publisher
    Laboratory-adapted and vaccine strains of measles virus (MV) induce type I interferon (IFN) in infected cells to a far greater extent than wild-type strains...
  15. Ludlow M, Allen I, Schneider Schaulies J. Systemic spread of measles virus: overcoming the epithelial and endothelial barriers. Thromb Haemost. 2009;102:1050-6 pubmed publisher
    ..entry receptor, signalling lymphocytic activation molecule (SLAM, CD150) essentially determines the tropism of measles virus (MV) for immune cells...
  16. Ennis M, Hu C, Naik S, Hallak L, Peng K, Russell S, et al. Mutations in the stalk region of the measles virus hemagglutinin inhibit syncytium formation but not virus entry. J Virol. 2010;84:10913-7 pubmed publisher
    b>Measles virus (MV) entry requires at least 2 viral proteins, the hemagglutinin (H) and fusion (F) proteins...
  17. Seki F, Yamada K, Nakatsu Y, Okamura K, Yanagi Y, Nakayama T, et al. The SI strain of measles virus derived from a patient with subacute sclerosing panencephalitis possesses typical genome alterations and unique amino acid changes that modulate receptor specificity and reduce membrane fusion activity. J Virol. 2011;85:11871-82 pubmed publisher
    ..SSPE) is a fatal sequela associated with measles and is caused by persistent infection of the brain with measles virus (MV). The SI strain was isolated in 1976 from a patient with SSPE and shows neurovirulence in animals...
  18. Clifford H, Hayden C, Khoo S, Zhang G, LE SOUEF P, Richmond P. CD46 measles virus receptor polymorphisms influence receptor protein expression and primary measles vaccine responses in naive Australian children. Clin Vaccine Immunol. 2012;19:704-10 pubmed publisher
    ..CD46 is a ubiquitously expressed specific receptor for vaccine strains of measles virus. CD46 polymorphisms have not been functionally investigated but may affect CD46 protein expression, which in ..
  19. Schoenhals M, Frecha C, Bruyer A, Caraux A, Veyrune J, Jourdan M, et al. Efficient transduction of healthy and malignant plasma cells by lentiviral vectors pseudotyped with measles virus glycoproteins. Leukemia. 2012;26:1663-70 pubmed publisher
    ..The ability to efficiently introduce and express a given gene into PCs opens the possibility to study in detail PC biology...
  20. Brindley M, Plemper R. Blue native PAGE and biomolecular complementation reveal a tetrameric or higher-order oligomer organization of the physiological measles virus attachment protein H. J Virol. 2010;84:12174-84 pubmed publisher
    ..that native H complexes extract predominantly in the form of loosely assembled tetramers from purified measles virus (MeV) particles and cells transiently expressing the viral envelope glycoproteins...
  21. Okonski K, Samuel C. Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1. J Virol. 2013;87:756-66 pubmed publisher
    ..Conversely, PKR amplifies IFN-? induction by measles virus (MV) and inhibits virus protein synthesis...
  22. Brindley M, Suter R, Schestak I, Kiss G, Wright E, Plemper R. A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion. J Virol. 2013;87:11693-703 pubmed publisher
    ..The measles virus (MeV) attachment (H) protein stalk domain is thought to directly engage F for fusion promotion...
  23. Zhang S, Cai W, Zhang Y, Jiang K, Zhang K, Wang W. Engineered measles virus Edmonston strain used as a novel oncolytic viral system against human neuroblastoma through a CD46 and nectin 4-independent pathway. Cancer Lett. 2012;325:227-37 pubmed publisher
    ..potential antitumor capability of the engineered Edmonston strain of the carcinoembryonic antigen-expressing measles virus (MV-CEA) against human NB...
  24. Li Z, Okonski K, Samuel C. Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus. J Virol. 2012;86:3787-94 pubmed publisher
    ..IFN-? induction following infection with either parental (wild-type [WT]) recombinant Moraten vaccine strain measles virus (MV) or isogenic knockout mutants deficient for either V (V(ko)) or C (C(ko)) protein expression...
  25. Lin W, Griffin D, Rota P, Papania M, CAPE S, Bennett D, et al. Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques. Proc Natl Acad Sci U S A. 2011;108:2987-92 pubmed publisher
    ..MVDP induced robust measles virus (MeV)-specific humoral and T-cell responses, without adverse effects, which completely protected the macaques ..
  26. Komune N, Ichinohe T, Ito M, Yanagi Y. Measles virus V protein inhibits NLRP3 inflammasome-mediated interleukin-1? secretion. J Virol. 2011;85:13019-26 pubmed publisher
    ..We demonstrate that measles virus (MV) infection induces caspase-1-dependent IL-1? secretion in the human macrophage-like cell line THP-1...
  27. Galanis E. Therapeutic potential of oncolytic measles virus: promises and challenges. Clin Pharmacol Ther. 2010;88:620-5 pubmed publisher
    b>Measles virus (MV) is a negative-strand RNA virus (paramyxovirus) with oncolytic properties...
  28. Cheng W, Lee L, Rota P, Yang D. Molecular evolution of measles viruses circulated in Taiwan 1992-2008. Virol J. 2009;6:219 pubmed publisher
    ..The more recent genotype H1 viruses had sequences that were identical to those currently circulating in China or associated with international importation of virus. ..
  29. Prodhomme E, Fack F, Revets D, Pirrotte P, Kremer J, Muller C. Extensive phosphorylation flanking the C-terminal functional domains of the measles virus nucleoprotein. J Proteome Res. 2010;9:5598-609 pubmed publisher
    The measles virus nucleoprotein (vNP) is the first and most abundant protein in infected cells. It plays numerous important roles including the encapsidation of genomic viral RNA and the transcription of viral proteins...
  30. Clifford H, Yerkovich S, Khoo S, Zhang G, Upham J, LE SOUEF P, et al. Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine. Immunogenetics. 2012;64:219-28 pubmed publisher
    ..b>Measles virus, an ssRNA virus, continues to cause serious morbidity and mortality worldwide despite available measles ..
  31. Gely S, Lowry D, Bernard C, Jensen M, Blackledge M, Costanzo S, et al. Solution structure of the C-terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C-terminal domain of the nucleoprotein. J Mol Recognit. 2010;23:435-47 pubmed publisher
    In this report, the solution structure of the nucleocapsid-binding domain of the measles virus phosphoprotein (XD, aa 459-507) is described...
  32. Frecha C, Levy C, Costa C, Negre D, Amirache F, Buckland R, et al. Measles virus glycoprotein-pseudotyped lentiviral vector-mediated gene transfer into quiescent lymphocytes requires binding to both SLAM and CD46 entry receptors. J Virol. 2011;85:5975-85 pubmed publisher
    ..Previously, we generated lentiviral vectors (LVs) pseudotyped with the Edmonston measles virus (MV) hemagglutinin and fusion glycoproteins (Hgps and Fgps) (H/F-LVs), which, for the first time, allowed ..
  33. Kessler J, Kremer J, Shulga S, Tikhonova N, Santibanez S, Mankertz A, et al. Revealing new measles virus transmission routes by use of sequence analysis of phosphoprotein and hemagglutinin genes. J Clin Microbiol. 2011;49:677-83 pubmed publisher
    With improved measles virus (MV) control, the genetic variability of the MV-nucleoprotein hypervariable region (NP-HVR) decreases...
  34. Levy C, Amirache F, Costa C, Frecha C, Muller C, Kweder H, et al. Lentiviral vectors displaying modified measles virus gp overcome pre-existing immunity in in vivo-like transduction of human T and B cells. Mol Ther. 2012;20:1699-712 pubmed publisher
    ..Previously, we generated lentiviral vectors (LVs) pseudotyped with Edmonston (Ed) measles virus (MV) hemagglutinin (H) and fusion (F) glycoproteins (H/F-LVs), which allowed efficient transduction of ..
  35. Katoh M, Kazuki Y, Kazuki K, Kajitani N, Takiguchi M, Nakayama Y, et al. Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer. BMC Biotechnol. 2010;10:37 pubmed publisher
    ..HAC) were transfected with genes encoding hemagglutinin (H) and fusion (F) proteins of an attenuated Measles Virus (MV) Edmonston strain...
  36. van der Vlist M, de Witte L, de Vries R, Litjens M, de Jong M, Fluitsma D, et al. Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4? T cells but are incapable of cross-presentation. Eur J Immunol. 2011;41:2619-31 pubmed publisher
    ..b>Measles virus (MV) is a highly infectious lymphotropic and myelotropic virus that enters the host via the respiratory tract...
  37. Li H, Peng K, Dingli D, Kratzke R, Russell S. Oncolytic measles viruses encoding interferon beta and the thyroidal sodium iodide symporter gene for mesothelioma virotherapy. Cancer Gene Ther. 2010;17:550-8 pubmed publisher
    ..The results suggest that oncolytic MVs that code for IFNbeta and NIS will be potent and versatile agents for the treatment of human mesothelioma. ..
  38. Tran Van H, Avota E, Börtlein C, Mueller N, Schneider Schaulies S. Measles virus modulates dendritic cell/T-cell communication at the level of plexinA1/neuropilin-1 recruitment and activity. Eur J Immunol. 2011;41:151-63 pubmed publisher
    b>Measles virus (MV)-infected DC fail to promote T-cell expansion, and this could explain important aspects of measles immunosuppression...
  39. Shi J, Zheng J, Huang H, Hu Y, Bian J, Xu D, et al. Measles incidence rate and a phylogenetic study of contemporary genotype H1 measles strains in China: is an improved measles vaccine needed?. Virus Genes. 2011;43:319-26 pubmed publisher
    ..primary vaccination effectively neutralized vaccine strains, the capacity in neutralizing H1 wild-type measles virus isolates was decreased fourfold...
  40. Navaratnarajah C, Negi S, Braun W, Cattaneo R. Membrane fusion triggering: three modules with different structure and function in the upper half of the measles virus attachment protein stalk. J Biol Chem. 2012;287:38543-51 pubmed publisher
    The measles virus (MV) fusion apparatus consists of a fusion protein and an attachment protein named hemagglutinin (H)...
  41. Haddad Boubaker S, Rezq M, Smeo M, Ben Yahia A, Abudher A, Slim A, et al. Genetic characterization of clade B measles viruses isolated in Tunisia and Libya 2002-2009 and a proposed new subtype within the B3 genotype. Virus Res. 2010;153:258-64 pubmed publisher
    ..6% with the same reference strains. This is the first report describing the genetic characteristics of measles viruses from clade B isolated in North Africa; the results suggest that these viruses represent a new subtype of genotype B3. ..
  42. Donnelly O, Errington Mais F, Steele L, Hadac E, Jennings V, Scott K, et al. Measles virus causes immunogenic cell death in human melanoma. Gene Ther. 2013;20:7-15 pubmed publisher
    ..b>Measles virus (MV) has not yet been tested in models of human melanoma...
  43. Duraisamy R, Rota P, Palani G, Elango V, Sambasivam M, Lowe L, et al. Molecular characterization of wild-type measles viruses in Tamil Nadu, India, during 2005-2006: relationship of genotype D8 strains from Tamil Nadu to global strains. J Med Virol. 2012;84:348-57 pubmed publisher
    ..D8 has multiple lineages and this has been linked with importation of measles into the USA and UK...
  44. Schlehuber L, McFadyen I, Shu Y, Carignan J, Duprex W, Forsyth W, et al. Towards ambient temperature-stable vaccines: the identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay. Vaccine. 2011;29:5031-9 pubmed publisher
    ..we describe a system that incorporates thermal stability screening into formulation design using heat labile measles virus as a prototype...
  45. Bhaskar A, Bala J, Varshney A, Yadava P. Expression of measles virus nucleoprotein induces apoptosis and modulates diverse functional proteins in cultured mammalian cells. PLoS ONE. 2011;6:e18765 pubmed publisher
    b>Measles virus nucleoprotein (N) encapsidates the viral RNA, protects it from endonucleases and forms a virus specific template for transcription and replication. It is the most abundant protein during viral infection...
  46. Abdullah H, Brankin B, Brady C, Cosby S. Wild-type measles virus infection upregulates poliovirus receptor-related 4 and causes apoptosis in brain endothelial cells by induction of tumor necrosis factor-related apoptosis-inducing ligand. J Neuropathol Exp Neurol. 2013;72:681-96 pubmed publisher
    Small numbers of brain endothelial cells (BECs) are infected in children with neurologic complications of measles virus (MV) infection...
  47. Leber M, Bossow S, Leonard V, Zaoui K, Grossardt C, Frenzke M, et al. MicroRNA-sensitive oncolytic measles viruses for cancer-specific vector tropism. Mol Ther. 2011;19:1097-106 pubmed publisher
    ..This is proof-of-concept that tropism restriction by tissue-specific microRNAs can be adapted to oncolytic MV to regulate viral replication and gene expression to maximize tumor specificity without compromising oncolytic efficacy. ..
  48. Penheiter A, Wegman T, Classic K, Dingli D, Bender C, Russell S, et al. Sodium iodide symporter (NIS)-mediated radiovirotherapy for pancreatic cancer. AJR Am J Roentgenol. 2010;195:341-9 pubmed publisher
    We have previously shown the therapeutic efficacy of an engineered oncolytic measles virus expressing the sodium iodide symporter reporter gene (MV-NIS) in mice with human pancreatic cancer xenografts...
  49. Touchefeu Y, Khan A, Borst G, Zaidi S, McLaughlin M, Roulstone V, et al. Optimising measles virus-guided radiovirotherapy with external beam radiotherapy and specific checkpoint kinase 1 inhibition. Radiother Oncol. 2013;108:24-31 pubmed publisher
    ..We have now evaluated NIS-expressing oncolytic measles virus (MV-NIS) combined with NIS-guided radioiodide, EBRT and specific checkpoint kinase 1 (Chk1) inhibition in head ..
  50. Zhang Y, Ding Z, Wang H, Li L, Pang Y, Brown K, et al. New measles virus genotype associated with outbreak, China. Emerg Infect Dis. 2010;16:943-7 pubmed publisher
    ..The new genotype designation will allow for better description of measles transmission patterns, especially in the Southeast Asian and Western Pacific regions. ..
  51. Saitoh M, Takeda M, Gotoh K, Takeuchi F, Sekizuka T, Kuroda M, et al. Molecular evolution of hemagglutinin (H) gene in measles virus genotypes D3, D5, D9, and H1. PLoS ONE. 2012;7:e50660 pubmed publisher
    We studied the molecular evolution of H gene in four prevalent Asian genotypes (D3, D5, D9, and H1) of measles virus (MeV). We estimated the evolutionary time scale of the gene by the bayesian Markov Chain Monte Carlo (MCMC) method...
  52. Leonard V, Hodge G, Reyes del Valle J, McChesney M, Cattaneo R. Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. J Virol. 2010;84:3413-20 pubmed publisher
    The signaling lymphocytic activation molecule (SLAM; CD150) is the immune cell receptor for measles virus (MV)...
  53. Bach P, Abel T, Hoffmann C, Gal Z, Braun G, Voelker I, et al. Specific elimination of CD133+ tumor cells with targeted oncolytic measles virus. Cancer Res. 2013;73:865-74 pubmed publisher
    ..Our results indicate that CD133-targeted measles viruses selectively eliminate CD133(+) cells from tumor tissue, offering a key tool for research in tumor biology and cancer therapy. ..
  54. Koethe S, Avota E, Schneider Schaulies S. Measles virus transmission from dendritic cells to T cells: formation of synapse-like interfaces concentrating viral and cellular components. J Virol. 2012;86:9773-81 pubmed publisher
    Transmission of measles virus (MV) to T cells by its early CD150(+) target cells is considered to be crucial for viral dissemination within the hematopoietic compartment...
  55. Devaux P, Hudacek A, Hodge G, Reyes del Valle J, McChesney M, Cattaneo R. A recombinant measles virus unable to antagonize STAT1 function cannot control inflammation and is attenuated in rhesus monkeys. J Virol. 2011;85:348-56 pubmed publisher
    Measles remains a leading cause of death worldwide among children because it suppresses immune function. The measles virus (MV) P gene encodes three proteins (P, V, and C) that interfere with innate immunity, controlling STAT1, STAT2, ..
  56. Takayama I, Sato H, Watanabe A, Omi Furutani M, Sugai A, Kanki K, et al. The nucleocapsid protein of measles virus blocks host interferon response. Virology. 2012;424:45-55 pubmed publisher
    b>Measles virus (MV) belongs to the genus Morbillivirus of the family Paramyxoviridae. A number of paramyxoviruses inhibit host interferon (IFN) signaling pathways in host immune systems by various mechanisms...
  57. de Vries R, Yüksel S, Osterhaus A, De Swart R. Specific CD8(+) T-lymphocytes control dissemination of measles virus. Eur J Immunol. 2010;40:388-95 pubmed publisher
    Measles continues to be an important cause of childhood mortality in developing countries. Measles virus (MV) is lymphotropic and infects high percentages of B- and T-lymphocytes in lymphoid tissues...
  58. Sanekata T, Fukuda T, Miura T, Morino H, Lee C, Maeda K, et al. Evaluation of the antiviral activity of chlorine dioxide and sodium hypochlorite against feline calicivirus, human influenza virus, measles virus, canine distemper virus, human herpesvirus, human adenovirus, canine adenovirus and canine parvovirus. Biocontrol Sci. 2010;15:45-9 pubmed
    ..dioxide gas solution (CD) and sodium hypochlorite (SH) against feline calicivirus, human influenza virus, measles virus, canine distemper virus, human herpesvirus, human adenovirus, canine adenovirus and canine parvovirus...
  59. Schuhmann K, Pfaller C, Conzelmann K. The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity. J Virol. 2011;85:3162-71 pubmed publisher
    ..Here we show that the immunosuppressive measles virus (MV; Morbillivirus genus, Paramyxoviridae) has evolved multiple functions to interfere with canonical NF-?B ..
  60. Salimi V, Mokhtari Azad T, Abbasi S, Noroozbabaei Z, Soltan Shahi R, Zahraie M, et al. Molecular epidemiology of measles virus in Iran 2009-2010: first detection of measles genotype H1. J Med Virol. 2011;83:2200-7 pubmed publisher
    b>Measles virus (MV) genotyping is an important component of measles surveillance in the context of monitoring immunization program effectiveness and documenting MV elimination...
  61. Miest T, Yaiw K, Frenzke M, Lampe J, Hudacek A, Springfeld C, et al. Envelope-chimeric entry-targeted measles virus escapes neutralization and achieves oncolysis. Mol Ther. 2011;19:1813-20 pubmed publisher
    b>Measles virus (MV) is a promising vector for cancer therapy and multivalent vaccination, but high prevalence of pre-existing neutralizing antibodies may reduce therapeutic efficacy, particularly following systemic administration...
  62. Iankov I, Allen C, Federspiel M, Myers R, Peng K, Ingle J, et al. Expression of immunomodulatory neutrophil-activating protein of Helicobacter pylori enhances the antitumor activity of oncolytic measles virus. Mol Ther. 2012;20:1139-47 pubmed publisher
    ..Here, we evaluated the therapeutic efficacy of measles virus (MV) strains engineered to express secretory NAP forms against metastatic breast cancer...
  63. Zhou Q, Schneider I, Gallet M, Kneissl S, Buchholz C. Resting lymphocyte transduction with measles virus glycoprotein pseudotyped lentiviral vectors relies on CD46 and SLAM. Virology. 2011;413:149-52 pubmed publisher
    The measles virus (MV) glycoproteins hemagglutinin (H) and fusion (F) were recently shown to mediate transduction of resting lymphocytes by lentiviral vectors...
  64. Zhou D, Zhang Y, Li Q, Chen Y, He B, Yang J, et al. Matrix protein-specific IgA antibody inhibits measles virus replication by intracellular neutralization. J Virol. 2011;85:11090-7 pubmed publisher
    b>Measles virus (MV) is still an imposing threat to public health...
  65. Kim D, Martinez Sobrido L, Choi C, Petroff N, Garcia Sastre A, Niewiesk S, et al. Induction of type I interferon secretion through recombinant Newcastle disease virus expressing measles virus hemagglutinin stimulates antibody secretion in the presence of maternal antibodies. J Virol. 2011;85:200-7 pubmed publisher
    b>Measles virus (MV) vaccine effectively protects seronegative individuals against infection...
  66. Waku Kouomou D, Freymuth F, du Châtelet I, Wild T, Horvat B. Co-circulation of multiple measles virus genotypes during an epidemic in France in 2008. J Med Virol. 2010;82:1033-43 pubmed publisher
    ..suggest that there are still many pockets of unvaccinated individuals helping to maintain the circulation of measles virus in the population...
  67. Kneissl S, Abel T, Rasbach A, Brynza J, Schneider Schaulies J, Buchholz C. Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies. PLoS ONE. 2012;7:e46667 pubmed publisher
    ..Recently, we have developed a targeting method for LVs by incorporating engineered measles virus (MV) glycoproteins, the hemagglutinin (H), responsible for receptor recognition, and the fusion protein into ..
  68. Curtale F, Perrelli F, Mantovani J, Ciofi Degli Atti M, Filia A, Nicoletti L, et al. Description of two measles outbreaks in the Lazio Region, Italy (2006-2007). Importance of pockets of low vaccine coverage in sustaining the infection. BMC Infect Dis. 2010;10:62 pubmed publisher
    ..An enhanced surveillance systems, which includes viral genotyping to document chains of transmission, is an essential tool for evaluating strategy to control and eliminate measles. ..
  69. Furuse Y, Suzuki A, Oshitani H. Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries. Virol J. 2010;7:52 pubmed publisher
    Measles, caused by measles virus (MeV), is a common infection in children. MeV is a member of the genus Morbillivirus and is most closely related to rinderpest virus (RPV), which is a pathogen of cattle...
  70. Pfaller C, Radeke M, Cattaneo R, Samuel C. Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R. J Virol. 2014;88:456-68 pubmed publisher
    b>Measles virus (MV) lacking expression of C protein (C(KO)) is a potent activator of the double-stranded RNA (dsRNA)-dependent protein kinase (PKR), whereas the isogenic parental virus expressing C protein is not...
  71. Hayford K, Al Emran H, Moss W, Shomik M, Bishai D, Levine O. Validation of an anti-measles virus-specific IgG assay with oral fluid samples for immunization surveillance in Bangladesh. J Virol Methods. 2013;193:512-8 pubmed publisher
    ..This study assessed the validity and reliability of the Microimmune anti-measles virus-specific IgG ELISA with oral fluid samples (OF-ELISA) among a random sample of children ages 12-16 months in ..
  72. Patel B, Dey A, Ghorani E, Kumar S, Malam Y, Rai L, et al. Differential cytopathology and kinetics of measles oncolysis in two primary B-cell malignancies provides mechanistic insights. Mol Ther. 2011;19:1034-40 pubmed publisher
    Clinical trials using vaccine measles virus (MV) as anticancer therapy are already underway...
  73. Abe Y, Hashimoto K, Watanabe M, Ohara S, Sato M, Kawasaki Y, et al. Characteristics of viruses derived from nude mice with persistent measles virus infection. J Virol. 2013;87:4170-5 pubmed publisher
    b>Measles virus (MV) isolates from patients with subacute sclerosing panencephalitis (SSPE) differ from wild-type MV virologically. However, few animal models have reported viruses with characteristics of the SSPE virus...
  74. Noyce R, Bondre D, Ha M, Lin L, Sisson G, Tsao M, et al. Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. PLoS Pathog. 2011;7:e1002240 pubmed publisher
    Vaccine and laboratory adapted strains of measles virus can use CD46 as a receptor to infect many human cell lines...
  75. Ayata M, Takeuchi K, Takeda M, Ohgimoto S, Kato S, Sharma L, et al. The F gene of the Osaka-2 strain of measles virus derived from a case of subacute sclerosing panencephalitis is a major determinant of neurovirulence. J Virol. 2010;84:11189-99 pubmed publisher
    b>Measles virus (MV) is the causative agent for acute measles and subacute sclerosing panencephalitis (SSPE)...
  76. Kavalenka A, Urbancic I, Belle V, Rouger S, Costanzo S, Kure S, et al. Conformational analysis of the partially disordered measles virus N(TAIL)-XD complex by SDSL EPR spectroscopy. Biophys J. 2010;98:1055-64 pubmed publisher
    ..We applied this approach to the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (N(TAIL)) both free and in complex with the X domain (XD, aa 459-507) of the viral ..
  77. Bankamp B, Takeda M, Zhang Y, Xu W, Rota P. Genetic characterization of measles vaccine strains. J Infect Dis. 2011;204 Suppl 1:S533-48 pubmed publisher
  78. Zhang X, Lu G, Qi J, Li Y, He Y, Xu X, et al. Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. Nat Struct Mol Biol. 2013;20:67-72 pubmed publisher
    b>Measles virus is a major public health concern worldwide. Three measles virus cell receptors have been identified so far, and the structures of the first two in complex with measles virus hemagglutinin (MV-H) have been reported...
  79. Iankov I, Haralambieva I, Galanis E. Immunogenicity of attenuated measles virus engineered to express Helicobacter pylori neutrophil-activating protein. Vaccine. 2011;29:1710-20 pubmed publisher
    ..pylori infection. Here we present the development of measles virus (MV) vaccine strain encoding the NAP antigen...
  80. Watanabe A, Yoneda M, Ikeda F, Terao Muto Y, Sato H, Kai C. CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells. J Virol. 2010;84:4183-93 pubmed publisher
    Measles is a highly contagious human disease caused by measles virus (MeV) and remains the leading cause of death in children, particularly in developing countries...
  81. Soye K, Trottier C, Richardson C, Ward B, Miller W. RIG-I is required for the inhibition of measles virus by retinoids. PLoS ONE. 2011;6:e22323 pubmed publisher
    ..Vitamin A can inhibit the replication of measles virus (MeV) in vitro through an RAR?- and type I interferon (IFN)-dependent mechanism...
  82. Noyce R, Richardson C. Nectin 4 is the epithelial cell receptor for measles virus. Trends Microbiol. 2012;20:429-39 pubmed publisher
    b>Measles virus (MV) causes acute respiratory disease, infects lymphocytes and multiple organs, and produces immune suppression leading to secondary infections...
  83. Zhang Y, Xu S, Wang H, Zhu Z, Ji Y, Liu C, et al. Single endemic genotype of measles virus continuously circulating in China for at least 16 years. PLoS ONE. 2012;7:e34401 pubmed publisher
    ..This is the first report that a single endemic genotype of measles virus has been found to be continuously circulating in one country for at least 16 years.
  84. Ludlow M, de Vries R, Lemon K, McQuaid S, Millar E, van Amerongen G, et al. Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus. J Gen Virol. 2013;94:1933-44 pubmed publisher
    b>Measles virus (MV), a member of the family Paramyxoviridae, remains a major cause of morbidity and mortality in the developing world...
  85. Desfosses A, Goret G, Farias Estrozi L, Ruigrok R, Gutsche I. Nucleoprotein-RNA orientation in the measles virus nucleocapsid by three-dimensional electron microscopy. J Virol. 2011;85:1391-5 pubmed publisher
    Recombinant measles virus nucleoprotein-RNA (N-RNA) helices were analyzed by negative-stain electron microscopy...
  86. Li H, Peng K, Russell S. Oncolytic measles virus encoding thyroidal sodium iodide symporter for squamous cell cancer of the head and neck radiovirotherapy. Hum Gene Ther. 2012;23:295-301 pubmed publisher
    Oncolytic measles virus (MV) encoding the human thyroidal sodium iodide symporter (MV-NIS) has proved to be safe after intraperitoneal or intravenous administration in patients with ovarian cancer or multiple myeloma, respectively, but ..
  87. Griffin D. Measles virus-induced suppression of immune responses. Immunol Rev. 2010;236:176-89 pubmed publisher
    ..In most individuals, the immune response is successful in eventually clearing measles virus (MV) infection and in establishing life-long immunity...
  88. Rota P, Brown K, Hübschen J, Muller C, Icenogle J, Chen M, et al. Improving global virologic surveillance for measles and rubella. J Infect Dis. 2011;204 Suppl 1:S506-13 pubmed publisher
    ..In addition, baseline virologic surveillance, especially for rubella, needs to be improved in many countries. This report contains a summary of recent improvements to the methods used for virologic surveillance...
  89. Zhao D, Chen P, Yang H, Wu Y, Zeng X, Zhao Y, et al. Live attenuated measles virus vaccine induces apoptosis and promotes tumor regression in lung cancer. Oncol Rep. 2013;29:199-204 pubmed publisher
    ..b>Measles virus oncolytic therapy has been reported to be effective in reducing tumor burden in immunocompetent ..