canine distemper virus

Summary

Summary: A species of MORBILLIVIRUS causing distemper in dogs, wolves, foxes, raccoons, and ferrets. Pinnipeds have also been known to contract Canine distemper virus from contact with domestic dogs.

Top Publications

  1. Mee A, Dixon J, Hoyland J, Davies M, Selby P, Mawer E. Detection of canine distemper virus in 100% of Paget's disease samples by in situ-reverse transcriptase-polymerase chain reaction. Bone. 1998;23:171-5 pubmed
    ..We have previously provided evidence that canine distemper virus (CDV) is present in approximately 65% of samples of pagetic bone, using in situ hybridization and RT-PCR; ..
  2. Daoust P, McBurney S, Godson D, van de Bildt M, Osterhaus A. Canine distemper virus-associated encephalitis in free-living lynx (Lynx canadensis) and bobcats (Lynx rufus) of eastern Canada. J Wildl Dis. 2009;45:611-24 pubmed
    ..The virus was identified as canine distemper virus (CDV) by reverse transcriptase polymerase chain reaction and nucleotide sequencing in four of five animals ..
  3. Guiserix M, Bahi Jaber N, Fouchet D, Sauvage F, Pontier D. The canine distemper epidemic in Serengeti: are lions victims of a new highly virulent canine distemper virus strain, or is pathogen circulation stochasticity to blame?. J R Soc Interface. 2007;4:1127-34 pubmed
    ..This mechanism may also be involved in other infectious disease emergences or re-emergences...
  4. Zhao J, Yan X, Chai X, Martella V, Luo G, Zhang H, et al. Phylogenetic analysis of the haemagglutinin gene of canine distemper virus strains detected from breeding foxes, raccoon dogs and minks in China. Vet Microbiol. 2010;140:34-42 pubmed publisher
    b>Canine distemper virus (CDV) infects a variety of carnivores, including wild and domestic Canidae...
  5. Cleaveland S, Appel M, Chalmers W, Chillingworth C, Kaare M, Dye C. Serological and demographic evidence for domestic dogs as a source of canine distemper virus infection for Serengeti wildlife. Vet Microbiol. 2000;72:217-27 pubmed
    Following an epidemic of canine distemper virus (CDV) in Serengeti lions in 1994, the role of domestic dogs in the epidemiology of the disease was investigated by serological and demographic analyses...
  6. van de Bildt M, Kuiken T, Visee A, Lema S, Fitzjohn T, Osterhaus A. Distemper outbreak and its effect on African wild dog conservation. Emerg Infect Dis. 2002;8:211-3 pubmed
    ..The causative agent was identified as Canine distemper virus (CDV) by means of histologic examination, virus isolation, reverse transcriptase-polymerase chain reaction ..
  7. Blixenkrone Møller M. Biological properties of phocine distemper virus and canine distemper virus. APMIS Suppl. 1993;36:1-51 pubmed
    ..To date the Morbillivirus genus in the Paramyxoviridae family comprises five established members, namely canine distemper virus (CDV), phocine distemper virus (PDV), measles virus (MV), rinderpest virus (RPV), and peste-des-petits-..
  8. Elia G, Decaro N, Martella V, Cirone F, Lucente M, Lorusso E, et al. Detection of canine distemper virus in dogs by real-time RT-PCR. J Virol Methods. 2006;136:171-6 pubmed
    b>Canine distemper virus is the etiological agent of a severe disease in dogs and many other carnivores...
  9. Singethan K, Topfstedt E, Schubert S, Duprex W, Rima B, Schneider Schaulies J. CD9-dependent regulation of Canine distemper virus-induced cell-cell fusion segregates with the extracellular domain of the haemagglutinin. J Gen Virol. 2006;87:1635-42 pubmed publisher
    Antibodies to CD9, a member of the tetraspan transmembrane-protein family, selectively inhibit Canine distemper virus (CDV)-induced cell-cell fusion...

More Information

Publications94

  1. Plattet P, Rivals J, Zuber B, Brunner J, Zurbriggen A, Wittek R. The fusion protein of wild-type canine distemper virus is a major determinant of persistent infection. Virology. 2005;337:312-26 pubmed
    The wild-type A75/17 canine distemper virus (CDV) strain induces a persistent infection in the central nervous system but infects cell lines very inefficiently...
  2. Bonami F, Rudd P, von Messling V. Disease duration determines canine distemper virus neurovirulence. J Virol. 2007;81:12066-70 pubmed
    ..To evaluate its contribution to canine distemper virus neurovirulence, we exchanged the H proteins of the wild-type strains 5804P and A75 and assessed the ..
  3. von Messling V, Cattaneo R. N-linked glycans with similar location in the fusion protein head modulate paramyxovirus fusion. J Virol. 2003;77:10202-12 pubmed
    ..We have characterized the three glycans attached to fusion (F) proteins of the morbilliviruses canine distemper virus and measles virus...
  4. Oni O, Wajjwalku W, Boodde O, Chumsing W. Canine distemper virus antibodies in the Asian elephant (Elaphas maximus). Vet Rec. 2006;159:420-1 pubmed
  5. Megid J, de Souza V, Teixeira C, Cortez A, Amorin R, Heinemman M, et al. Canine distemper virus in a crab-eating fox (Cerdocyon thous) in Brazil: case report and phylogenetic analyses. J Wildl Dis. 2009;45:527-30 pubmed
    Although canine distemper is enzootic worldwide and has a wide host range, there are no reports of canine distemper virus in crab-eating foxes (Cerdocyon thous) that provide information on virus phylogeny and histopathologic lesions...
  6. Nielsen L, Andersen M, Jensen T, Blixenkrone Møller M, Bolt G. Changes in the receptorbinding haemagglutinin protein of wild-type morbilliviruses are not required for adaptation to Vero cells. Virus Genes. 2003;27:157-62 pubmed
    ..to Vero cells for the receptorbinding haemagglutinin (H) gene of four syncytia-forming isolates of canine distemper virus (CDV) and of a dolphin morbillivirus isolate...
  7. Gese E, Schultz R, Johnson M, Williams E, Crabtree R, Ruff R. Serological survey for diseases in free-ranging coyotes (Canis latrans) in Yellowstone National Park, Wyoming. J Wildl Dis. 1997;33:47-56 pubmed
    ..Presence of antibodies against canine distemper virus (CDV) was associated with the age of the coyote, with 88%, 54%, 23%, and 0% prevalence among adults, ..
  8. Selby P, Davies M, Mee A. Canine distemper virus induces human osteoclastogenesis through NF-kappaB and sequestosome 1/P62 activation. J Bone Miner Res. 2006;21:1750-6 pubmed
    ..We studied the effects of CDV on osteoclastogenesis in vitro and showed that CDV had a dose-dependent effect on osteoclastogenesis, through a possible mechanism involving activation of NF-kappaB and sequestosome 1/p62...
  9. von Messling V, Milosevic D, Cattaneo R. Tropism illuminated: lymphocyte-based pathways blazed by lethal morbillivirus through the host immune system. Proc Natl Acad Sci U S A. 2004;101:14216-21 pubmed
    The immunosuppressive properties of morbilliviruses including measles and canine distemper virus (CDV) are well known, but the host cells supporting infection are poorly characterized...
  10. Rima B, Duprex W. Morbilliviruses and human disease. J Pathol. 2006;208:199-214 pubmed
    ..b>Canine distemper virus (CDV) and rinderpest virus (RPV) cause a similar but distinctive pathology in dogs and cattle, ..
  11. Rivals J, Plattet P, Currat Zweifel C, Zurbriggen A, Wittek R. Adaptation of canine distemper virus to canine footpad keratinocytes modifies polymerase activity and fusogenicity through amino acid substitutions in the P/V/C and H proteins. Virology. 2007;359:6-18 pubmed
    The wild-type canine distemper virus (CDV) strain A75/17 induces a non-cytocidal infection in cultures of canine footpad keratinocytes (CFKs) but produces very little progeny virus...
  12. Grone A, Engelhardt P, Zurbriggen A. Canine distemper virus infection: proliferation of canine footpad keratinocytes. Vet Pathol. 2003;40:574-8 pubmed
    The proliferation of footpad keratinocytes of canine distemper virus (CDV)-infected dogs was investigated...
  13. Martella V, Elia G, Lucente M, Decaro N, Lorusso E, Banyai K, et al. Genotyping canine distemper virus (CDV) by a hemi-nested multiplex PCR provides a rapid approach for investigation of CDV outbreaks. Vet Microbiol. 2007;122:32-42 pubmed
    ..The method could be useful for molecular epidemiological studies of CDV, providing a tool for large-scale studies, and for the diagnosis of vaccine-related disease. ..
  14. Bronson E, Deem S, Sanchez C, Murray S. Serologic response to a canarypox-vectored canine distemper virus vaccine in the giant panda (Ailuropoda melanoleuca). J Zoo Wildl Med. 2007;38:363-6 pubmed
    The giant panda (Ailuropoda melanoleuca) is known to be susceptible to natural infection with canine distemper virus (CDV)...
  15. Seehusen F, Orlando E, Wewetzer K, Baumgartner W. Vimentin-positive astrocytes in canine distemper: a target for canine distemper virus especially in chronic demyelinating lesions?. Acta Neuropathol. 2007;114:597-608 pubmed
    In canine distemper demyelinating leukoencephalitis (DL), caused by canine distemper virus (CDV), astrocytes represent the main virus target...
  16. Lednicky J, Meehan T, Kinsel M, Dubach J, Hungerford L, Sarich N, et al. Effective primary isolation of wild-type canine distemper virus in MDCK, MV1 Lu and Vero cells without nucleotide sequence changes within the entire haemagglutinin protein gene and in subgenomic sections of the fusion and phospho protein genes. J Virol Methods. 2004;118:147-57 pubmed
    b>Canine distemper virus (CDV) is an important pathogen of many carnivores. We are developing a field-based model of morbillivirus virulence and pathogenesis through a study of distemper in naturally infected free-ranging raccoons...
  17. Vandevelde M, Zurbriggen A. Demyelination in canine distemper virus infection: a review. Acta Neuropathol. 2005;109:56-68 pubmed
    b>Canine distemper virus (CDV) causes severe immunosuppression and neurological disease in dogs, associated with demyelination, and is a model for multiple sclerosis in man...
  18. Uema M, Ohashi K, Wakasa C, Kai C. Phylogenetic and restriction fragment length polymorphism analyses of hemagglutinin (H) protein of canine distemper virus isolates from domestic dogs in Japan. Virus Res. 2005;109:59-63 pubmed
    ..of 995 nucleotides within the hemagglutinin (H) gene open reading frame (ORF) of field isolates of 23 canine distemper virus (CDV) strains isolated from domestic dogs in Japan between 1982 and 1998...
  19. Lan N, Yamaguchi R, Hirai T, Kai K, Morishita K. Relationship between growth behavior in vero cells and the molecular characteristics of recent isolated classified in the Asia 1 and 2 groups of canine distemper virus. J Vet Med Sci. 2009;71:457-61 pubmed
    Ten recent isolates of canine distemper virus (CDV) strains were classified according to the growth ability and development of syncytial cytopathic effects (CPE) in Vero cells...
  20. Courtenay O, Quinnell R, Chalmers W. Contact rates between wild and domestic canids: no evidence of parvovirus or canine distemper virus in crab-eating foxes. Vet Microbiol. 2001;81:9-19 pubmed
    ..Foxes and dogs were serologically and clinically monitored for exposure to canine parvovirus (CPV-2) and canine distemper virus (CDV), pathogens known to have caused wildlife population declines elsewhere...
  21. Fischer L, Tronel J, Pardo David C, Tanner P, Colombet G, Minke J, et al. Vaccination of puppies born to immune dams with a canine adenovirus-based vaccine protects against a canine distemper virus challenge. Vaccine. 2002;20:3485-97 pubmed
    ..the vector, it has the potential to provide a solution for the vaccination of young puppies born to canine distemper virus (CDV)-immune dams...
  22. von Messling V, Zimmer G, Herrler G, Haas L, Cattaneo R. The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity. J Virol. 2001;75:6418-27 pubmed
    b>Canine distemper virus (CDV) and measles virus (MV) cause severe illnesses in their respective hosts. The viruses display a characteristic cytopathic effect by forming syncytia in susceptible cells...
  23. Santos N, Almendra C, Tavares L. Serologic survey for canine distemper virus and canine parvovirus in free-ranging wild carnivores from Portugal. J Wildl Dis. 2009;45:221-6 pubmed
    A serologic survey for Canine distemper virus (CDV) and canine parvovirus (CPV) was performed on serum and lung extract from an opportunistic sample of 120 free-ranging wild carnivores (13 species) from Portugal, collected from 1995 to ..
  24. Sobrino R, Arnal M, Luco D, Gortazar C. Prevalence of antibodies against canine distemper virus and canine parvovirus among foxes and wolves from Spain. Vet Microbiol. 2008;126:251-6 pubmed
    ..137 foxes (Vulpes vulpes) and 37 wolves (Canis lupus) in Spain for 1997-2007 to detect antibodies against canine distemper virus (CDV) and against canine parvovirus (CPV) by indirect ELISA. Antibodies against CDV were detected in 18...
  25. Elia G, Belloli C, Cirone F, Lucente M, Caruso M, Martella V, et al. In vitro efficacy of ribavirin against canine distemper virus. Antiviral Res. 2008;77:108-13 pubmed
    Despite vaccination, canine distemper virus (CDV) remains one of the important pathogen of dogs with worldwide distribution...
  26. Mochizuki M, Hashimoto M, Hagiwara S, Yoshida Y, Ishiguro S. Genotypes of canine distemper virus determined by analysis of the hemagglutinin genes of recent isolates from dogs in Japan. J Clin Microbiol. 1999;37:2936-42 pubmed
    Canine distemper of domestic dogs is caused by canine distemper virus (CDV), a member of the morbilliviruses...
  27. Lednicky J, Dubach J, Kinsel M, Meehan T, Bocchetta M, Hungerford L, et al. Genetically distant American Canine distemper virus lineages have recently caused epizootics with somewhat different characteristics in raccoons living around a large suburban zoo in the USA. Virol J. 2004;1:2 pubmed
    ..We hypothesized that a more lethal variant of the local Canine distemper virus (CDV) lineage had emerged in 2001, and sought the genetic basis that led to increased virulence...
  28. von Messling V, Cattaneo R. Amino-terminal precursor sequence modulates canine distemper virus fusion protein function. J Virol. 2002;76:4172-80 pubmed
    ..The predicted reading frame of the canine distemper virus (CDV) F protein is more complex, with a short hydrophobic sequence beginning 115 codons downstream of the ..
  29. Plattet P, Cherpillod P, Wiener D, Zipperle L, Vandevelde M, Wittek R, et al. Signal peptide and helical bundle domains of virulent canine distemper virus fusion protein restrict fusogenicity. J Virol. 2007;81:11413-25 pubmed publisher
    Persistence in canine distemper virus (CDV) infection is correlated with very limited cell-cell fusion and lack of cytolysis induced by the neurovirulent A75/17-CDV compared to that of the cytolytic Onderstepoort vaccine strain...
  30. Kennedy S, Kuiken T, Jepson P, Deaville R, Forsyth M, Barrett T, et al. Mass die-Off of Caspian seals caused by canine distemper virus. Emerg Infect Dis. 2000;6:637-9 pubmed
    ..Lesions characteristic of morbillivirus infection were found in tissue specimens from dead seals. Canine distemper virus infection was identified by serologic examination, reverse transcriptase- polymerase chain reaction, and ..
  31. Schatzberg S, Li Q, Porter B, Barber R, Claiborne M, Levine J, et al. Broadly reactive pan-paramyxovirus reverse transcription polymerase chain reaction and sequence analysis for the detection of Canine distemper virus in a case of canine meningoencephalitis of unknown etiology. J Vet Diagn Invest. 2009;21:844-9 pubmed
    Despite the immunologic protection associated with routine vaccination protocols, Canine distemper virus (CDV) remains an important pathogen of dogs...
  32. Jozwik A, Frymus T. Comparison of the immunofluorescence assay with RT-PCR and nested PCR in the diagnosis of canine distemper. Vet Res Commun. 2005;29:347-59 pubmed
    Two pairs of primers were prepared, both localized within the sequences of the nucleoprotein gene (NP) of canine distemper virus (CDV). A number of experiments were done to optimize the conditions of RT-PCR and nested PCR methods...
  33. Calderon M, Remorini P, Periolo O, Iglesias M, Mattion N, La Torre J. Detection by RT-PCR and genetic characterization of canine distemper virus from vaccinated and non-vaccinated dogs in Argentina. Vet Microbiol. 2007;125:341-9 pubmed
    RT-PCR was used to detect canine distemper virus (CDV) RNA in clotted blood from Argentine domestic dogs. The NP gene was detected in 73 out of 99 blood samples analyzed...
  34. Frolich K, Czupalla O, Haas L, Hentschke J, Dedek J, Fickel J. Epizootiological investigations of canine distemper virus in free-ranging carnivores from Germany. Vet Microbiol. 2000;74:283-92 pubmed
    b>Canine distemper virus (CDV) infects a broad range of carnivores. To assess whether wild carnivores may play a role in the epidemiology of CDV in domestic dogs in Germany, the seroprevalence of CDV was determined...
  35. Ikeda Y, Nakamura K, Miyazawa T, Chen M, Kuo T, Lin J, et al. Seroprevalence of canine distemper virus in cats. Clin Diagn Lab Immunol. 2001;8:641-4 pubmed
    A seroepidemiological survey of canine distemper virus (CDV) infection in Asian felids revealed that the prevalence of antibodies varied depending on region and, in some cases, exposure to dogs...
  36. Pardo I, Johnson G, Kleiboeker S. Phylogenetic characterization of canine distemper viruses detected in naturally infected dogs in North America. J Clin Microbiol. 2005;43:5009-17 pubmed
    ..For five of the seven dogs, disease caused by canine distemper virus (CDV) infection was suspected based on clinical signs...
  37. Seki F, Ono N, Yamaguchi R, Yanagi Y. Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells. J Virol. 2003;77:9943-50 pubmed
    ..signaling lymphocyte activation molecule (SLAM; also known as CD150) acts as a cellular receptor for canine distemper virus (CDV). In this study, we established Vero cells stably expressing canine SLAM (Vero.DogSLAMtag cells)...
  38. Engelhardt P, Wyder M, Zurbriggen A, Grone A. Canine distemper virus associated proliferation of canine footpad keratinocytes in vitro. Vet Microbiol. 2005;107:1-12 pubmed
    Infection of canine footpads with canine distemper virus (CDV) can result in so-called hard pad disease characterized by footpad epidermal proliferation and hyperkeratosis...
  39. Kim Y, Cho K, Youn H, Yoo H, Han H. Detection of canine distemper virus (CDV) through one step RT-PCR combined with nested PCR. J Vet Sci. 2001;2:59-63 pubmed
    ..transcription PCR (RT-PCR) combined nested PCR was set up to increase efficiency in the diagnosis of canine distemper virus (CDV) infection after developement of nested PCR...
  40. Megid J, Teixeira C, Amorin R, Cortez A, Heinemann M, de Paula Antunes J, et al. First identification of canine distemper virus in hoary fox (Lycalopex vetulus): pathologic aspects and virus phylogeny. J Wildl Dis. 2010;46:303-5 pubmed
    b>Canine distemper virus (CDV) has been reported in several wild animal species, but there have been no reports of CDV in hoary fox (Lycalopex vetulus)...
  41. Wiener D, Plattet P, Cherpillod P, Zipperle L, Doherr M, Vandevelde M, et al. Synergistic inhibition in cell-cell fusion mediated by the matrix and nucleocapsid protein of canine distemper virus. Virus Res. 2007;129:145-54 pubmed
    b>Canine distemper virus (CDV) causes a chronic, demyelinating, progressive or relapsing neurological disease in dogs, because CDV persists in the CNS...
  42. Oglesbee M, Liu Z, Kenney H, Brooks C. The highly inducible member of the 70 kDa family of heat shock proteins increases canine distemper virus polymerase activity. J Gen Virol. 1996;77 ( Pt 9):2125-35 pubmed
    ..in vitro induction of the stress response promotes cytopathic effect mediated by infection with canine distemper virus (CDV)...
  43. Imhoff H, von Messling V, Herrler G, Haas L. Canine distemper virus infection requires cholesterol in the viral envelope. J Virol. 2007;81:4158-65 pubmed
    ..Using flow cytometry and fluorescence microscopy, we demonstrate that infection of cells by canine distemper virus (CDV) was not impaired after cellular cholesterol had been depleted by the drug methyl-beta-cyclodextrin...
  44. R thlisberger A, Wiener D, Schweizer M, Peterhans E, Zurbriggen A, Plattet P. Two domains of the V protein of virulent canine distemper virus selectively inhibit STAT1 and STAT2 nuclear import. J Virol. 2010;84:6328-43 pubmed publisher
    b>Canine distemper virus (CDV) causes in dogs a severe systemic infection, with a high frequency of demyelinating encephalitis...
  45. Endo Y, Uema M, Miura R, Tsukiyama Kohara K, Tsujimoto H, Yoneda K, et al. Prevalence of canine distemper virus, feline immunodeficiency virus and feline leukemia virus in captive African lions (Panthera leo) in Japan. J Vet Med Sci. 2004;66:1587-9 pubmed
    Sero-prevalences of canine distemper virus (CDV), feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) were evaluated in 20 captive lions in two Japanese zoos. Anti-CDV antibody was detected in 13 of 20 lions...
  46. Schobesberger M, Summerfield A, Doherr M, Zurbriggen A, Griot C. Canine distemper virus-induced depletion of uninfected lymphocytes is associated with apoptosis. Vet Immunol Immunopathol. 2005;104:33-44 pubmed
    b>Canine distemper virus (CDV), a negative stranded RNA morbillivirus, causes a multisystemic disease in dogs, which is associated with a severe immune suppression...
  47. Suter S, Chein M, von Messling V, Yip B, Cattaneo R, Vernau W, et al. In vitro canine distemper virus infection of canine lymphoid cells: a prelude to oncolytic therapy for lymphoma. Clin Cancer Res. 2005;11:1579-87 pubmed
    ..The purpose of this study was to determine if canine lymphoid cells could be infected in vitro with MV or canine distemper virus (CDV, the canine Morbillivirus equivalent of MV) and determine if in vitro viral infection leads to ..
  48. Martella V, Elia G, Buonavoglia C. Canine distemper virus. Vet Clin North Am Small Anim Pract. 2008;38:787-97, vii-viii pubmed publisher
    ..Notwithstanding, the incidence of canine distemper virus (CDV)-related disease in canine populations throughout the world seems to have increased in the past ..
  49. Plattet P, Zweifel C, Wiederkehr C, Belloy L, Cherpillod P, Zurbriggen A, et al. Recovery of a persistent Canine distemper virus expressing the enhanced green fluorescent protein from cloned cDNA. Virus Res. 2004;101:147-53 pubmed
    Wild-type A75/17-Canine distemper virus (CDV) is a highly virulent strain, which induces a persistent infection in the central nervous system (CNS) with demyelinating disease...
  50. Schobesberger M, Zurbriggen A, Doherr M, Weissenbock H, Vandevelde M, Lassmann H, et al. Demyelination precedes oligodendrocyte loss in canine distemper virus-induced encephalitis. Acta Neuropathol. 2002;103:11-9 pubmed
    b>Canine distemper virus (CDV), a negative-stranded RNA morbillivirus, causes a persistent infection within the central nervous system resulting in a progressive, multifocal demyelinating disease...
  51. Puff C, Krudewig C, Imbschweiler I, Baumgartner W, Alldinger S. Influence of persistent canine distemper virus infection on expression of RECK, matrix-metalloproteinases and their inhibitors in a canine macrophage/monocytic tumour cell line (DH82). Vet J. 2009;182:100-7 pubmed publisher
    ..polymerase chain reaction (RT-qPCR) was used to determine the effect of persistent infection with canine distemper virus (CDV) infection on the expression of MMPs and their inhibitors (TIMPS) in a canine macrophage/monocytic ..
  52. Si W, Zhou S, Wang Z, Cui S. A multiplex reverse transcription-nested polymerase chain reaction for detection and differentiation of wild-type and vaccine strains of canine distemper virus. Virol J. 2010;7:86 pubmed publisher
    ..RT-nPCR) method was developed for the detection and differentiation of wild-type and vaccine strains of canine distemper virus (CDV)...
  53. Demeter Z, Lakatos B, Palade E, Kozma T, Forgách P, Rusvai M. Genetic diversity of Hungarian canine distemper virus strains. Vet Microbiol. 2007;122:258-69 pubmed
    ..150 samples collected from dogs showing respiratory, gastrointestinal and neurological signs suggesting canine distemper virus (CDV) infection were examined...
  54. Biek R, Ruth T, Murphy K, Anderson C, Johnson M, DeSimone R, et al. Factors associated with pathogen seroprevalence and infection in Rocky Mountain cougars. J Wildl Dis. 2006;42:606-15 pubmed
    ..virus (FIV), feline parvovirus (FPV), feline coronavirus (FCoV), feline calicivirus (FCV), canine distemper virus (CDV), feline herpesvirus (FHV), and Yersinia pestis...
  55. Fujita K, Miura R, Yoneda M, Shimizu F, Sato H, Muto Y, et al. Host range and receptor utilization of canine distemper virus analyzed by recombinant viruses: Involvement of heparin-like molecule in CDV infection. Virology. 2007;359:324-35 pubmed
    ..viruses expressing enhanced green fluorescent protein (EGFP) or firefly luciferase from cDNA clones of the canine distemper virus (CDV) (a Japanese field isolate, Yanaka strain)...
  56. Sultan S, Charoenvisal N, Lan N, Yamaguchi R, Maeda K, Kai K. The Asia 2 specific signal peptide region and other domains in fusion protein genes characterized Asia 1 and Asia 2 canine distemper viruses. Virol J. 2009;6:157 pubmed publisher
    Although the presence of Asia 2 group of canine distemper virus (CDV) was known by the sequencing and phylogenetic analysis of hemagglutinin (H) gene, the fusion (F) protein gene sequence of Asia 2 group had not been identified...
  57. Sanekata T, Fukuda T, Miura T, Morino H, Lee C, Maeda K, et al. Evaluation of the antiviral activity of chlorine dioxide and sodium hypochlorite against feline calicivirus, human influenza virus, measles virus, canine distemper virus, human herpesvirus, human adenovirus, canine adenovirus and canine parvovirus. Biocontrol Sci. 2010;15:45-9 pubmed
    ..CD) and sodium hypochlorite (SH) against feline calicivirus, human influenza virus, measles virus, canine distemper virus, human herpesvirus, human adenovirus, canine adenovirus and canine parvovirus...
  58. An D, Yoon S, Park J, No I, Park B. Phylogenetic characterization of canine distemper virus isolates from naturally infected dogs and a marten in Korea. Vet Microbiol. 2008;132:389-95 pubmed publisher
    We sequenced the hemagglutinin (H) genes from four canine distemper virus (CDV) isolates obtained from three dogs and a marten in Korea...
  59. Anderson D, von Messling V. Region between the canine distemper virus M and F genes modulates virulence by controlling fusion protein expression. J Virol. 2008;82:10510-8 pubmed publisher
    Morbilliviruses, including measles and canine distemper virus (CDV), are nonsegmented, negative-stranded RNA viruses that cause severe diseases in humans and animals...
  60. Tatsuo H, Ono N, Yanagi Y. Morbilliviruses use signaling lymphocyte activation molecules (CD150) as cellular receptors. J Virol. 2001;75:5842-50 pubmed
    Morbilliviruses comprise measles virus, canine distemper virus, rinderpest virus, and several other viruses that cause devastating human and animal diseases accompanied by severe immunosuppression and lymphopenia...
  61. Zipperle L, Langedijk J, Orvell C, Vandevelde M, Zurbriggen A, Plattet P. Identification of key residues in virulent canine distemper virus hemagglutinin that control CD150/SLAM-binding activity. J Virol. 2010;84:9618-24 pubmed publisher
    ..Here, we provide evidence that three key residues in the virulent canine distemper virus A75/17 H protein (Y525, D526, and R529), clustering at the rim of a large recessed groove created by beta-..
  62. Junge R, Bauman K, King M, Gompper M. A serologic assessment of exposure to viral pathogens and Leptospira in an urban raccoon (Procyon lotor) population inhabiting a large zoological park. J Zoo Wildl Med. 2007;38:18-26 pubmed
    ..Louis, Missouri (USA), were surveyed for exposure to canine distemper virus (CDV), canine adenovirus 1 (CAV-1); feline parvovirus (FPV; =feline panleukopenia), and several serovars ..
  63. Masuda M, Sato H, Kamata H, Katsuo T, Takenaka A, Miura R, et al. Characterization of monoclonal antibodies directed against the canine distemper virus nucleocapsid protein. Comp Immunol Microbiol Infect Dis. 2006;29:157-65 pubmed
    We have established four monoclonal antibodies (MAbs) against the nucleocapsid protein (NP) of canine distemper virus (CDV). A competitive binding assay has revealed that the MAbs are directed against two antigenic domains...
  64. Sun Z, Li A, Ye H, Shi Y, Hu Z, Zeng L. Natural infection with canine distemper virus in hand-feeding Rhesus monkeys in China. Vet Microbiol. 2010;141:374-8 pubmed publisher
    An outbreak of canine distemper virus (CDV) in hand-feeding Rhesus monkeys in China was reported...
  65. von Messling V, Springfeld C, Devaux P, Cattaneo R. A ferret model of canine distemper virus virulence and immunosuppression. J Virol. 2003;77:12579-91 pubmed
    b>Canine distemper virus (CDV) infects many carnivores, including ferrets and dogs, and is the member of the Morbillivirus genus most easily amenable to experimentation in a homologous small-animal system...
  66. Del Puerto H, Martins A, Moro L, Milsted A, Alves F, Braz G, et al. Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus. Genet Mol Res. 2010;9:151-61 pubmed publisher
    Canine distemper is an immunosuppressive disease caused by the canine distemper virus (CDV). Pathogenesis mainly involves the central nervous system and immunosuppression...
  67. Akerstedt J, Lillehaug A, Larsen I, Eide N, Arnemo J, Handeland K. Serosurvey for canine distemper virus, canine adenovirus, Leptospira interrogans, and Toxoplasma gondii in free-ranging canids in Scandinavia and Svalbard. J Wildl Dis. 2010;46:474-80 pubmed
    Prevalence of antibodies reactive to canine distemper virus (CDV), canine adenovirus type 1 (CAV-1), Leptospira interrogans serovars Canicola and Icterohaemorrhagiae, and Toxoplasma gondii were examined in free-ranging Scandinavian canids...
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    ..The usage of two hamster cell lines suggested to be useful to characterize the field isolates biologically. ..
  69. Kajita M, Katayama H, Murata T, Kai C, Hori M, Ozaki H. Canine distemper virus induces apoptosis through caspase-3 and -8 activation in vero cells. J Vet Med B Infect Dis Vet Public Health. 2006;53:273-7 pubmed
    We investigated the signal-transduction pathway of canine distemper virus-Onderstepoort (CDV-Ond) vaccine strain-mediated apoptosis in Vero cells. Canine distemper virus-Onderstepoort at a multiplicity of infection (MOI) of 0...
  70. Singethan K, Müller N, Schubert S, Lüttge D, Krementsov D, Khurana S, et al. CD9 clustering and formation of microvilli zippers between contacting cells regulates virus-induced cell fusion. Traffic. 2008;9:924-35 pubmed publisher
    ..K41, a CD9-specific monoclonal antibody, inhibits the release of HIV-1 and canine distemper virus (CDV)- but not measles virus (MV)-induced cell-cell fusion...
  71. D Intino G, Vaccari F, Sivilia S, Scagliarini A, Gandini G, Giardino L, et al. A molecular study of hippocampus in dogs with convulsion during canine distemper virus encephalitis. Brain Res. 2006;1098:186-95 pubmed
    ..504-523 rat EAAC1) in 6 dogs sacrificed immediately after seizure attack during encephalomyelitis due to canine distemper virus (CDV) (as assessed by clinical examination, RT-PCR and viral RNA detection either in blood or brain tissue ..
  72. Saito T, Alfieri A, Wosiacki S, Negrão F, Morais H, Alfieri A. Detection of canine distemper virus by reverse transcriptase-polymerase chain reaction in the urine of dogs with clinical signs of distemper encephalitis. Res Vet Sci. 2006;80:116-9 pubmed
    ..the use of the reverse transcriptase-polymerase chain reaction (RT-PCR) in urine samples to diagnose canine distemper virus in dogs with progressive neurological disease...
  73. Cherpillod P, Zipperle L, Wittek R, Zurbriggen A. An mRNA region of the canine distemper virus fusion protein gene lacking AUG codons can promote protein expression. Arch Virol. 2004;149:1971-83 pubmed
    b>Canine distemper virus (CDV) produces a glycosylated type I fusion protein (F) with an internal hydrophobic signal sequence beginning around 115 residues downstream of the first AUG used for translation initiation...
  74. Stanton J, Brown C, Poet S, Lipscomb T, Saliki J, Frasca S. Retrospective differentiation of canine distemper virus and phocine distemper virus in phocids. J Wildl Dis. 2004;40:53-9 pubmed
    ..of a novel seminested reverse transcriptase polymerase chain reaction (RT-PCR) to detect and differentiate canine distemper virus (CDV) and phocine distemper virus (PDV). Four antibodies made against PDV were able to detect both viruses...
  75. Koutinas A, Baumgartner W, Tontis D, Polizopoulou Z, Saridomichelakis M, Lekkas S. Histopathology and immunohistochemistry of canine distemper virus-induced footpad hyperkeratosis (hard Pad disease) in dogs with natural canine distemper. Vet Pathol. 2004;41:2-9 pubmed
    Hard pad disease represents an uncommon manifestation of canine distemper virus (CDV) infection with a still uncertain pathogenesis...
  76. Damien B, Martina B, Losch S, Mossong J, Osterhaus A, Muller C. Prevalence of antibodies against canine distemper virus among red foxes in Luxembourg. J Wildl Dis. 2002;38:856-9 pubmed
    b>Canine distemper virus (CDV) has a wide host spectrum, and during the past years, distemper has been observed in species that were previously not considered to be susceptible...
  77. Grone A, Fonfara S, Baumgartner W. Cell type-dependent cytokine expression after canine distemper virus infection. Viral Immunol. 2002;15:493-505 pubmed
    ..These findings suggest that pro-inflammatory cytokines, namely IL-1, IL-6, and TNF, which might play an important role in CDV pathogenesis, are induced in a cell-specific manner. ..
  78. Martella V, Pratelli A, Cirone F, Zizzo N, Decaro N, Tinelli A, et al. Detection and genetic characterization of canine distemper virus (CDV) from free-ranging red foxes in Italy. Mol Cell Probes. 2002;16:77-83 pubmed
  79. Chan K, Hsieh H, Wang H, Lee Y, Sung M, Wong M, et al. Identification, expression and antigenic analysis of recombinant hemagglutinin proteins of canine distemper virus. J Virol Methods. 2009;155:18-24 pubmed publisher
    Canine distemper (CD) is a widely distributed disease of dogs, caused by the canine distemper virus (CDV)...
  80. Techangamsuwan S, Haas L, Rohn K, Baumgartner W, Wewetzer K. Distinct cell tropism of canine distemper virus strains to adult olfactory ensheathing cells and Schwann cells in vitro. Virus Res. 2009;144:195-201 pubmed publisher
    b>Canine distemper virus (CDV) can enter the brain via infection of olfactory neurons. Whether olfactory ensheathing cells (OECs) are also infected by CDV, and if yes, how they respond to the virus has remained enigmatic...
  81. Gese E, Schultz R, Rongstad O, Andersen D. Prevalence of antibodies against canine parvovirus and canine distemper virus in wild coyotes in southeastern Colorado. J Wildl Dis. 1991;27:320-3 pubmed
    ..Colorado (USA) was collected and analyzed for prevalence of antibody to canine parvovirus (CPV) and canine distemper virus (CDV) from 1985 to 1988...
  82. Lan N, Yamaguchi R, Uchida K, Sugano S, Tateyama S. Growth profiles of recent canine distemper isolates on Vero cells expressing canine signalling lymphocyte activation molecule (SLAM). J Comp Pathol. 2005;133:77-81 pubmed
    Fresh samples of lymph node, lung and cerebrum taken post mortem from dogs no. 1, 2 and 3 yielded canine distemper virus (CDV) strains 007 Lm, 009 L and 011 C, respectively...
  83. von Messling V, Milosevic D, Devaux P, Cattaneo R. Canine distemper virus and measles virus fusion glycoprotein trimers: partial membrane-proximal ectodomain cleavage enhances function. J Virol. 2004;78:7894-903 pubmed
    ..the F(1b) fragment, including the transmembrane domain and cytoplasmic tail, in cells expressing the canine distemper virus (CDV) or mumps virus F protein...
  84. Hirama K, Togashi K, Wakasa C, Yoneda M, Nishi T, Endo Y, et al. Cytotoxic T-lymphocyte activity specific for hemagglutinin (H) protein of canine distemper virus in dogs. J Vet Med Sci. 2003;65:109-12 pubmed
    Cytotoxic T-lymphocyte (CTL) responses to hemagglutinin (H) protein of canine distemper virus (CDV) were evaluated in dogs using the replication-deficient adenovirus protein expression system...
  85. Almberg E, Cross P, Smith D. Persistence of canine distemper virus in the Greater Yellowstone ecosystem's carnivore community. Ecol Appl. 2010;20:2058-74 pubmed
    b>Canine distemper virus (CDV) is an acute, highly immunizing pathogen that should require high densities and large populations of hosts for long-term persistence, yet CDV persists among terrestrial carnivores with small, patchily ..