nipah virus

Summary

Summary: A species of HENIPAVIRUS, closely related to HENDRA VIRUS, which emerged in Peninsular Malaysia in 1998. It causes a severe febrile VIRAL ENCEPHALITIS in humans and also encephalitis and RESPIRATORY TRACT INFECTIONS in pigs. Fruit bats (PTEROPUS) are the natural host.

Top Publications

  1. Aljofan M, Saubern S, Meyer A, Marsh G, Meers J, Mungall B. Characteristics of Nipah virus and Hendra virus replication in different cell lines and their suitability for antiviral screening. Virus Res. 2009;142:92-9 pubmed publisher
    ..We evaluated ten different cell lines for their susceptibility to Hendra and Nipah virus infection and their sensitivity of detection of the effects of the broad spectrum antiviral, ribavirin and nine ..
  2. Wang X, Ge J, Hu S, Wang Q, Wen Z, Chen H, et al. Efficacy of DNA immunization with F and G protein genes of Nipah virus. Ann N Y Acad Sci. 2006;1081:243-5 pubmed
    ..response of DNA immunization with two mammalian codon optimized envelope glycoprotein genes, F and G, of Nipah virus in a mouse model...
  3. Biering S, Huang A, Vu A, Robinson L, Bradel Tretheway B, Choi E, et al. N-Glycans on the Nipah virus attachment glycoprotein modulate fusion and viral entry as they protect against antibody neutralization. J Virol. 2012;86:11991-2002 pubmed publisher
    b>Nipah virus (NiV) is the deadliest known paramyxovirus. Membrane fusion is essential for NiV entry into host cells and for the virus' pathological induction of cell-cell fusion (syncytia)...
  4. Ong S, Yusoff K, Kho C, Abdullah J, Tan W. Mutagenesis of the nucleocapsid protein of Nipah virus involved in capsid assembly. J Gen Virol. 2009;90:392-7 pubmed publisher
    The nucleocapsid protein of Nipah virus produced in Escherichia coli assembled into herringbone-like particles...
  5. Chua K, Wong E, Cropp B, Hyatt A. Role of electron microscopy in Nipah virus outbreak investigation and control. Med J Malaysia. 2007;62:139-42 pubmed
  6. Xiao C, Liu Y, Jiang Y, Magoffin D, Guo H, Xuan H, et al. Monoclonal antibodies against the nucleocapsid proteins of henipaviruses: production, epitope mapping and application in immunohistochemistry. Arch Virol. 2008;153:273-81 pubmed
    ..antibodies (mAbs) were generated by immunizing BALB/C mice with recombinant nucleocapsid protein (N) of Nipah virus (NiV) and Hendra virus (HeV) expressed in E. coli...
  7. Middleton D, Morrissy C, van der Heide B, Russell G, Braun M, Westbury H, et al. Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus). J Comp Pathol. 2007;136:266-72 pubmed
    Seventeen grey-headed fruit bats (Pteropus poliocephalus) were inoculated subcutaneously with an isolate of Nipah virus derived from a fatally infected human...
  8. Xu Y, Lou Z, Liu Y, Cole D, Su N, Qin L, et al. Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus. Acta Crystallogr D Biol Crystallogr. 2004;60:1161-4 pubmed publisher
    ..Crystals of the fusion core of Nipah virus have been grown at 291 K using PEG 4000 as precipitant. The diffraction pattern of the crystal extends to 2...
  9. Xu K, Rajashankar K, Chan Y, Himanen J, Broder C, Nikolov D. Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3. Proc Natl Acad Sci U S A. 2008;105:9953-8 pubmed publisher
    b>Nipah virus (NiV) and Hendra virus are the type species of the highly pathogenic paramyxovirus genus Henipavirus, which can cause severe respiratory disease and fatal encephalitis infections in humans, with case fatality rates ..

More Information

Publications99

  1. Porotto M, Orefice G, Yokoyama C, Mungall B, Realubit R, Sganga M, et al. Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy. J Virol. 2009;83:5148-55 pubmed publisher
    ..Given the established safety profile and broad experience with chloroquine in humans, the results described here provide an option for treating individuals infected by these deadly viruses...
  2. Aljofan M, Porotto M, Moscona A, Mungall B. Development and validation of a chemiluminescent immunodetection assay amenable to high throughput screening of antiviral drugs for Nipah and Hendra virus. J Virol Methods. 2008;149:12-9 pubmed publisher
    ..The current experiments describe for the first time, a high throughput screening method amenable for direct assessment of live henipavirus antiviral drug activity. ..
  3. Stachowiak B, Weingartl H. Nipah virus infects specific subsets of porcine peripheral blood mononuclear cells. PLoS ONE. 2012;7:e30855 pubmed publisher
    b>Nipah virus (NiV), a zoonotic paramyxovirus, is highly contagious in swine, and can cause fatal infections in humans following transmission from the swine host...
  4. Shaw M, Cardenas W, Zamarin D, Palese P, Basler C. Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways. J Virol. 2005;79:6078-88 pubmed
    The Nipah virus V and W proteins, which are encoded by the P gene via RNA editing, have a common N-terminal domain but unique C-terminal domains...
  5. McEachern J, Bingham J, Crameri G, Green D, Hancock T, Middleton D, et al. A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats. Vaccine. 2008;26:3842-52 pubmed publisher
    b>Nipah virus (NiV) and Hendra virus (HeV) are closely related deadly zoonotic paramyxoviruses that have emerged and re-emerged over the last 10 years...
  6. Zhu Q, Biering S, Mirza A, Grasseschi B, Mahon P, Lee B, et al. Individual N-glycans added at intervals along the stalk of the Nipah virus G protein prevent fusion but do not block the interaction with the homologous F protein. J Virol. 2013;87:3119-29 pubmed publisher
    ..However, despite extensive efforts, the F-interactive site(s) on the Nipah virus (NiV) G attachment glycoprotein has not been identified...
  7. Diederich S, Dietzel E, Maisner A. Nipah virus fusion protein: influence of cleavage site mutations on the cleavability by cathepsin L, trypsin and furin. Virus Res. 2009;145:300-6 pubmed publisher
    b>Nipah virus (NiV), a highly pathogenic member of the Paramyxoviridae which originated from bats, encodes for a fusion (F) protein which is proteolytically processed within endosomes by cathepsin L...
  8. Chua K. Introduction: Nipah virus--discovery and origin. Curr Top Microbiol Immunol. 2012;359:1-9 pubmed publisher
    ..This chapter briefly describes the initial discovery of Nipah virus and the challenges encountered during the initial identification and characterisation of the aetiological agent ..
  9. Chang L, Ali A, Hassan S, AbuBakar S. Nipah virus RNA synthesis in cultured pig and human cells. J Med Virol. 2006;78:1105-12 pubmed
    b>Nipah virus infection of porcine stable kidney cells (PS), human neuronal cells (SK-N-MC), human lung fibroblasts cells (MRC-5), and human monocytes (THP-1) were examined...
  10. Yu F, Khairullah N, Inoue S, Balasubramaniam V, Berendam S, Teh L, et al. Serodiagnosis using recombinant nipah virus nucleocapsid protein expressed in Escherichia coli. J Clin Microbiol. 2006;44:3134-8 pubmed
    b>Nipah virus nucleocapsid (NiV-N) protein was expressed in Escherichia coli and purified by histidine tag-based affinity chromatography...
  11. Zhu Z, Bossart K, Bishop K, Crameri G, Dimitrov A, McEachern J, et al. Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody. J Infect Dis. 2008;197:846-53 pubmed publisher
    We have previously identified neutralizing human monoclonal antibodies against Nipah virus (NiV) and Hendra virus (HeV) by panning a large nonimmune antibody library against a soluble form of the HeV attachment-envelope glycoprotein G (..
  12. Shaw M, Garcia Sastre A, Palese P, Basler C. Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively. J Virol. 2004;78:5633-41 pubmed
    In previous reports it was demonstrated that the Nipah virus V and W proteins have interferon (IFN) antagonist activity due to their ability to block signaling from the IFN-alpha/beta receptor (J. J. Rodriguez, J. P. Parisien, and C. M...
  13. Yoneda M, Guillaume V, Ikeda F, Sakuma Y, Sato H, Wild T, et al. Establishment of a Nipah virus rescue system. Proc Natl Acad Sci U S A. 2006;103:16508-13 pubmed
    b>Nipah virus (NiV), a paramyxovirus, was first discovered in Malaysia in 1998 in an outbreak of infection in pigs and humans and incurred a high fatality rate in humans...
  14. Fogarty R, Halpin K, Hyatt A, Daszak P, Mungall B. Henipavirus susceptibility to environmental variables. Virus Res. 2008;132:140-4 pubmed publisher
  15. Torres Velez F, Shieh W, Rollin P, Morken T, Brown C, Ksiazek T, et al. Histopathologic and immunohistochemical characterization of Nipah virus infection in the guinea pig. Vet Pathol. 2008;45:576-85 pubmed publisher
    Mortality rate in humans infected with Nipah virus (NiV) has been reported as high as 92%...
  16. Halpin K, Bankamp B, Harcourt B, Bellini W, Rota P. Nipah virus conforms to the rule of six in a minigenome replication assay. J Gen Virol. 2004;85:701-7 pubmed
    To study the replication of Nipah virus (NiV), a minigenome replication assay that does not require the use of infectious virus was developed...
  17. Wacharapluesadee S, Boongird K, Wanghongsa S, Ratanasetyuth N, Supavonwong P, Saengsen D, et al. A longitudinal study of the prevalence of Nipah virus in Pteropus lylei bats in Thailand: evidence for seasonal preference in disease transmission. Vector Borne Zoonotic Dis. 2010;10:183-90 pubmed publisher
    After 12 serial Nipah virus outbreaks in humans since 1998, it has been noted that all except the initial event in Malaysia occurred during the first 5 months of the year...
  18. Bossart K, McEachern J, Hickey A, Choudhry V, Dimitrov D, Eaton B, et al. Neutralization assays for differential henipavirus serology using Bio-Plex protein array systems. J Virol Methods. 2007;142:29-40 pubmed
    Hendra virus (HeV) and Nipah virus (NiV) are related emerging paramyxoviruses classified in the genus Henipavirus. Both cause fatal disease in animals and humans and are classified as biosafety level 4 pathogens...
  19. Pager C, Craft W, Patch J, Dutch R. A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L. Virology. 2006;346:251-7 pubmed
    The Nipah virus fusion (F) protein is proteolytically processed to F1 + F2 subunits. We demonstrate here that cathepsin L is involved in this important maturation event. Cathepsin inhibitors ablated cleavage of Nipah F...
  20. Chattopadhyay A, Rose J. Complementing defective viruses that express separate paramyxovirus glycoproteins provide a new vaccine vector approach. J Virol. 2011;85:2004-11 pubmed publisher
    ..In the process of generating an experimental Nipah virus (a paramyxovirus) vaccine, we generated two defective VSV?G vectors, each expressing one of the two Nipah virus ..
  21. Vigant F, Lee B. Hendra and nipah infection: pathology, models and potential therapies. Infect Disord Drug Targets. 2011;11:315-36 pubmed
    ..Hendra and Nipah virus are members of a newly identified genus of emerging paramyxoviruses, Henipavirus...
  22. Porotto M, Yokoyama C, Palermo L, Mungall B, Aljofan M, Cortese R, et al. Viral entry inhibitors targeted to the membrane site of action. J Virol. 2010;84:6760-8 pubmed publisher
    ..cause of lower respiratory tract diseases in infants, and the emerging zoonotic viruses Hendra virus (HeV) and Nipah virus (NiV), which cause lethal central nervous system diseases-the addition of cholesterol to a paramyxovirus HRC-..
  23. Chadha M, Comer J, Lowe L, Rota P, Rollin P, Bellini W, et al. Nipah virus-associated encephalitis outbreak, Siliguri, India. Emerg Infect Dis. 2006;12:235-40 pubmed
    ..Because Siliguri is in close proximity to Bangladesh, where outbreaks of Nipah virus (NiV) infection were recently described, clinical material obtained during the Siliguri outbreak was ..
  24. AbuBakar S, Chang L, Ali A, Sharifah S, Yusoff K, Zamrod Z. Isolation and molecular identification of Nipah virus from pigs. Emerg Infect Dis. 2004;10:2228-30 pubmed
    Nipah viruses from pigs from a Malaysian 1998 outbreak were isolated and sequenced. At least two different Nipah virus strains, including a previously unreported strain, were identified...
  25. Chang L, Ali A, Hassan S, AbuBakar S. Quantitative estimation of Nipah virus replication kinetics in vitro. Virol J. 2006;3:47 pubmed
    b>Nipah virus is a zoonotic virus isolated from an outbreak in Malaysia in 1998. The virus causes infections in humans, pigs, and several other domestic animals. It has also been isolated from fruit bats...
  26. Defang G, Khetawat D, Broder C, Quinnan G. Induction of neutralizing antibodies to Hendra and Nipah glycoproteins using a Venezuelan equine encephalitis virus in vivo expression system. Vaccine. 2010;29:212-20 pubmed publisher
    The emergence of Hendra Virus (HeV) and Nipah Virus (NiV) which can cause fatal infections in both animals and humans has triggered a search for an effective vaccine...
  27. Tamin A, Harcourt B, Lo M, Roth J, Wolf M, Lee B, et al. Development of a neutralization assay for Nipah virus using pseudotype particles. J Virol Methods. 2009;160:1-6 pubmed publisher
    b>Nipah virus (NiV) and Hendra virus (HeV) are zoonotic paramyxoviruses capable of causing severe disease in humans and animals. These viruses require biosafety level 4 (BSL-4) containment...
  28. Homaira N, Rahman M, Hossain M, Epstein J, Sultana R, Khan M, et al. Nipah virus outbreak with person-to-person transmission in a district of Bangladesh, 2007. Epidemiol Infect. 2010;138:1630-6 pubmed publisher
    In February 2007 an outbreak of Nipah virus (NiV) encephalitis in Thakurgaon District of northwest Bangladesh affected seven people, three of whom died...
  29. Sazzad H, Hossain M, Gurley E, Ameen K, Parveen S, Islam M, et al. Nipah virus infection outbreak with nosocomial and corpse-to-human transmission, Bangladesh. Emerg Infect Dis. 2013;19:210-7 pubmed publisher
    Active Nipah virus encephalitis surveillance identified an encephalitis cluster and sporadic cases in Faridpur, Bangladesh, in January 2010. We identified 16 case-patients; 14 of these patients died...
  30. Luby S, Gurley E. Epidemiology of henipavirus disease in humans. Curr Top Microbiol Immunol. 2012;359:25-40 pubmed publisher
    ..In the large outbreak in Malaysia where Nipah virus (NiV) was first identified, most human infections resulted from close contact with NiV infected pigs...
  31. Escaffre O, Borisevich V, Rockx B. Pathogenesis of Hendra and Nipah virus infection in humans. J Infect Dev Ctries. 2013;7:308-11 pubmed publisher
    Hendra virus (HeV) and Nipah virus (NiV) are emerging zoonotic viruses that cause severe and often lethal respiratory illness and encephalitis in humans...
  32. Luby S, Gurley E, Hossain M. Transmission of human infection with Nipah virus. Clin Infect Dis. 2009;49:1743-8 pubmed publisher
    b>Nipah virus (NiV) is a paramyxovirus whose reservoir host is fruit bats of the genus Pteropus. Occasionally the virus is introduced into human populations and causes severe illness characterized by encephalitis or respiratory disease...
  33. Ng B, Lim C, Yeoh A, Lee W. Neuropsychiatric sequelae of Nipah virus encephalitis. J Neuropsychiatry Clin Neurosci. 2004;16:500-4 pubmed
    The authors followed nine patients with Nipah virus encephalitis over the course of 24 months. Eight of the nine developed psychiatric features assigned to the encephalitis...
  34. Pulliam J, Field H, Olival K. Nipah virus strain variation. Emerg Infect Dis. 2005;11:1978-9; author reply 1979 pubmed
  35. Wang Y, Park A, Lake M, Pentecost M, Torres B, Yun T, et al. Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding. PLoS Pathog. 2010;6:e1001186 pubmed publisher
    ..We report here that the nuclear-cytoplasmic trafficking of the Nipah virus matrix (NiV-M) protein and associated post-translational modification play a critical role in matrix-mediated ..
  36. Rahman S, Hassan S, Olival K, Mohamed M, Chang L, Hassan L, et al. Characterization of Nipah virus from naturally infected Pteropus vampyrus bats, Malaysia. Emerg Infect Dis. 2010;16:1990-3 pubmed publisher
    We isolated and characterized Nipah virus (NiV) from Pteropus vampyrus bats, the putative reservoir for the 1998 outbreak in Malaysia, and provide evidence of viral recrudescence...
  37. Weingartl H, Berhane Y, Caswell J, Loosmore S, Audonnet J, Roth J, et al. Recombinant nipah virus vaccines protect pigs against challenge. J Virol. 2006;80:7929-38 pubmed
    b>Nipah virus (NiV), of the family Paramyxoviridae, was isolated in 1999 in Malaysia from a human fatality in an outbreak of severe human encephalitis, when human infections were linked to transmission of the virus from pigs...
  38. Diederich S, Maisner A. Molecular characteristics of the Nipah virus glycoproteins. Ann N Y Acad Sci. 2007;1102:39-50 pubmed
    b>Nipah virus (NiV) is a highly pathogenic paramyxovirus, which emerged in 1998 from fruit bats in Malaysia and caused an outbreak of severe respiratory disease in pigs and fatal encephalitis in humans with high mortality rates...
  39. Georges Courbot M, Contamin H, Faure C, Loth P, Baize S, Leyssen P, et al. Poly(I)-poly(C12U) but not ribavirin prevents death in a hamster model of Nipah virus infection. Antimicrob Agents Chemother. 2006;50:1768-72 pubmed
    Clinical nonrandomized trials demonstrate some efficacy for ribavirin in the treatment of patients with severe Nipah virus-induced encephalitis...
  40. Field H, Mackenzie J, Daszak P. Henipaviruses: emerging paramyxoviruses associated with fruit bats. Curr Top Microbiol Immunol. 2007;315:133-59 pubmed
    ..Hendra virus was first reported in horses and thence humans in Australia in 1994; Nipah virus was first reported in pigs and thence humans in Malaysia in 1998...
  41. Mirza A, Aguilar H, Zhu Q, Mahon P, Rota P, Lee B, et al. Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors. J Biol Chem. 2011;286:17851-60 pubmed publisher
    The fusion (F) proteins of Newcastle disease virus (NDV) and Nipah virus (NiV) are both triggered by binding to receptors, mediated in both viruses by a second protein, the attachment protein...
  42. Clayton B, Middleton D, Bergfeld J, Haining J, Arkinstall R, Wang L, et al. Transmission routes for nipah virus from Malaysia and Bangladesh. Emerg Infect Dis. 2012;18:1983-93 pubmed publisher
    Human infections with Nipah virus in Malaysia and Bangladesh are associated with markedly different patterns of transmission and pathogenicity...
  43. Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, et al. Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo. J Virol. 2013;87:2094-108 pubmed publisher
    ..Here we took advantage of the natural tropism of Nipah virus (NiV), whose attachment envelope glycoprotein has picomolar affinity for ephrinB2, a molecule proposed as a ..
  44. Blum L, Khan R, Nahar N, Breiman R. In-depth assessment of an outbreak of Nipah encephalitis with person-to-person transmission in Bangladesh: implications for prevention and control strategies. Am J Trop Med Hyg. 2009;80:96-102 pubmed
    ..Differing popular and medical views of illness caused conflict and rejection of biomedical recommendations. Future investigators should consider local perceptions of disease and treatment when developing outbreak strategies...
  45. Lee B. Envelope-receptor interactions in Nipah virus pathobiology. Ann N Y Acad Sci. 2007;1102:51-65 pubmed
    Nipah (NiV) and Hendra (HeV) viruses are members of the newly defined Henipavirus genus of the Paramyxoviridae. Nipah virus (NiV) is an emergent paramyxovirus that causes fatal encephalitis in up to 70% of infected patients, and there is ..
  46. Guillaume V, Wong K, Looi R, Georges Courbot M, Barrot L, Buckland R, et al. Acute Hendra virus infection: Analysis of the pathogenesis and passive antibody protection in the hamster model. Virology. 2009;387:459-65 pubmed publisher
    Hendra virus (HeV) and Nipah virus (NiV) are recently-emerged, closely related and highly pathogenic paramyxoviruses...
  47. de Wit E, Bushmaker T, Scott D, Feldmann H, Munster V. Nipah virus transmission in a hamster model. PLoS Negl Trop Dis. 2011;5:e1432 pubmed publisher
    Based on epidemiological data, it is believed that human-to-human transmission plays an important role in Nipah virus outbreaks...
  48. Talekar A, Devito I, Salah Z, Palmer S, Chattopadhyay A, Rose J, et al. Identification of a region in the stalk domain of the nipah virus receptor binding protein that is critical for fusion activation. J Virol. 2013;87:10980-96 pubmed publisher
    Paramyxoviruses, including the emerging lethal human Nipah virus (NiV) and the avian Newcastle disease virus (NDV), enter host cells through fusion of the viral and target cell membranes...
  49. Aguilar H, Aspericueta V, Robinson L, Aanensen K, Lee B. A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade. J Virol. 2010;84:8033-41 pubmed publisher
    The deadly paramyxovirus Nipah virus (NiV) contains a fusion glycoprotein (F) with canonical structural and functional features common to its class...
  50. Bonaparte M, Dimitrov A, Bossart K, Crameri G, Mungall B, Bishop K, et al. Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus. Proc Natl Acad Sci U S A. 2005;102:10652-7 pubmed
    Hendra virus (HeV) and Nipah virus (NiV) belong to the genus Henipavirus of the family Paramyxoviridae and are unique in that they exhibit a broad species tropism and cause fatal disease in both animals and humans...
  51. Lo M, Rota P. The emergence of Nipah virus, a highly pathogenic paramyxovirus. J Clin Virol. 2008;43:396-400 pubmed publisher
    b>Nipah virus first emerged in Malaysia and Singapore between 1998 and 1999, causing severe febrile encephalitis in humans with a mortality rate of close to 40%...
  52. Diederich S, Thiel L, Maisner A. Role of endocytosis and cathepsin-mediated activation in Nipah virus entry. Virology. 2008;375:391-400 pubmed publisher
    The recent discovery that the Nipah virus (NiV) fusion protein (F) is activated by endosomal cathepsin L raised the question if NiV utilize pH- and protease-dependent mechanisms of entry...
  53. Guillaume V, Lefeuvre A, Faure C, Marianneau P, Buckland R, Lam S, et al. Specific detection of Nipah virus using real-time RT-PCR (TaqMan). J Virol Methods. 2004;120:229-37 pubmed
    ..In this study, TaqMan RT-PCR of the Nipah nucleoprotein has been developed so that Nipah virus RNA in field specimens or laboratory material can be characterized rapidly and specifically and quantitated...
  54. Eshaghi M, Tan W, Yusoff K. Identification of epitopes in the nucleocapsid protein of Nipah virus using a linear phage-displayed random peptide library. J Med Virol. 2005;75:147-52 pubmed
    ..was used to identify specific epitopes of antibodies in pooled sera of swine naturally infected by Nipah virus. The selected heptapeptides were aligned with protein sequences of Nipah virus and several putative epitopes ..
  55. Nahar N, Mondal U, Sultana R, Hossain M, Khan M, Gurley E, et al. Piloting the use of indigenous methods to prevent Nipah virus infection by interrupting bats' access to date palm sap in Bangladesh. Health Promot Int. 2013;28:378-86 pubmed publisher
    ..Fruit bats (Pteropus giganteus) also drink raw sap and may contaminate the sap by shedding Nipah virus through saliva and urine...
  56. Geisbert T, Feldmann H, Broder C. Animal challenge models of henipavirus infection and pathogenesis. Curr Top Microbiol Immunol. 2012;359:153-77 pubmed publisher
    The henipaviruses, Hendra virus (HeV), and Nipah virus (NiV), are enigmatic emerging pathogens that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans...
  57. Yuan J, Marsh G, Khetawat D, Broder C, Wang L, Shi Z. Mutations in the G-H loop region of ephrin-B2 can enhance Nipah virus binding and infection. J Gen Virol. 2011;92:2142-52 pubmed publisher
    b>Nipah virus (NiV) and Hendra virus (HeV) are zoonotic paramyxoviruses classified in the genus Henipavirus of the family Paramyxoviridae...
  58. Luby S, Rahman M, Hossain M, Blum L, Husain M, Gurley E, et al. Foodborne transmission of Nipah virus, Bangladesh. Emerg Infect Dis. 2006;12:1888-94 pubmed
    ..Serum specimens were available from 3; 2 had immunoglobulin M antibodies against Nipah virus by capture enzyme immunoassay...
  59. Negrete O, Chu D, Aguilar H, Lee B. Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage. J Virol. 2007;81:10804-14 pubmed
    The henipaviruses, Nipah virus (NiV) and Hendra virus (HeV), are lethal emerging paramyxoviruses. EphrinB2 and ephrinB3 have been identified as receptors for henipavirus entry...
  60. Dimitrov D, Wang L. In utero transmission of Nipah virus: role played by pregnancy and vertical transmission in Henipavirus epidemiology. J Infect Dis. 2007;196:807-9 pubmed
  61. Erbar S, Maisner A. Nipah virus infection and glycoprotein targeting in endothelial cells. Virol J. 2010;7:305 pubmed publisher
    The highly pathogenic Nipah virus (NiV) causes fatal respiratory and brain infections in animals and humans. The major hallmark of the infection is a systemic endothelial infection, predominantly in the CNS...
  62. Kaku Y, Noguchi A, Marsh G, McEachern J, Okutani A, Hotta K, et al. A neutralization test for specific detection of Nipah virus antibodies using pseudotyped vesicular stomatitis virus expressing green fluorescent protein. J Virol Methods. 2009;160:7-13 pubmed publisher
    b>Nipah virus (NiV) is a new zoonotic paramyxovirus that emerged in 1998 and is now classified in the genus Henipavirus along with the closely related Hendra virus (HeV)...
  63. Sendow I, Field H, Adjid A, Ratnawati A, Breed A, Darminto -, et al. Screening for Nipah virus infection in West Kalimantan province, Indonesia. Zoonoses Public Health. 2010;57:499-503 pubmed publisher
    Compared to other viruses, research on Nipah virus has been limited in Indonesia because attributable disease outbreaks have not been reported...
  64. Montgomery J, Hossain M, Gurley E, Carroll G, Croisier A, Bertherat E, et al. Risk factors for Nipah virus encephalitis in Bangladesh. Emerg Infect Dis. 2008;14:1526-32 pubmed publisher
    b>Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh...
  65. Homaira N, Rahman M, Hossain M, Nahar N, Khan R, Rahman M, et al. Cluster of Nipah virus infection, Kushtia District, Bangladesh, 2007. PLoS ONE. 2010;5:e13570 pubmed publisher
    ..In March 2007, we investigated a cluster of Nipah encephalitis to identify risk factors for Nipah infection in Bangladesh...
  66. Diederich S, Sauerhering L, Weis M, Altmeppen H, Schaschke N, Reinheckel T, et al. Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment. J Virol. 2012;86:3736-45 pubmed publisher
    Proteolytic activation of the fusion protein of the highly pathogenic Nipah virus (NiV F) is a prerequisite for the production of infectious particles and for virus spread via cell-to-cell fusion...
  67. Mathieu C, Guillaume V, Volchkova V, Pohl C, Jacquot F, Looi R, et al. Nonstructural Nipah virus C protein regulates both the early host proinflammatory response and viral virulence. J Virol. 2012;86:10766-75 pubmed publisher
    b>Nipah virus (NiV) is a highly pathogenic, negative-strand RNA paramyxovirus that has recently emerged from flying foxes to cause serious human disease...
  68. Eaton B, Broder C, Middleton D, Wang L. Hendra and Nipah viruses: different and dangerous. Nat Rev Microbiol. 2006;4:23-35 pubmed
    Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore and Bangladesh...
  69. Zhu Z, Dimitrov A, Bossart K, Crameri G, Bishop K, Choudhry V, et al. Potent neutralization of Hendra and Nipah viruses by human monoclonal antibodies. J Virol. 2006;80:891-9 pubmed
    Hendra virus (HeV) and Nipah virus (NiV) are closely related emerging viruses comprising the Henipavirus genus of the Paramyxovirinae...
  70. Kong D, Wen Z, Su H, Ge J, Chen W, Wang X, et al. Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs. Virology. 2012;432:327-35 pubmed publisher
    b>Nipah virus (NiV), a member of the Paramyxoviridae family, causes deadly encephalitis in humans and huge economic losses to the pig industry...
  71. Patch J, Han Z, McCarthy S, Yan L, Wang L, Harty R, et al. The YPLGVG sequence of the Nipah virus matrix protein is required for budding. Virol J. 2008;5:137 pubmed publisher
    b>Nipah virus (NiV) is a recently emerged paramyxovirus capable of causing fatal disease in a broad range of mammalian hosts, including humans...
  72. Butler D. Fatal fruit bat virus sparks epidemics in southern Asia. Nature. 2004;429:7 pubmed
  73. Aguilar H, Iorio R. Henipavirus membrane fusion and viral entry. Curr Top Microbiol Immunol. 2012;359:79-94 pubmed publisher
    ..Here, we review these mechanisms and the current gaps in our knowledge in the field...
  74. Harit A, Ichhpujani R, Gupta S, Gill K, Lal S, Ganguly N, et al. Nipah/Hendra virus outbreak in Siliguri, West Bengal, India in 2001. Indian J Med Res. 2006;123:553-60 pubmed
    ..This outbreak was investigated by a team of scientists from four major institutions, and the findings are presented here...
  75. Moll M, Diederich S, Klenk H, Czub M, Maisner A. Ubiquitous activation of the Nipah virus fusion protein does not require a basic amino acid at the cleavage site. J Virol. 2004;78:9705-12 pubmed
    b>Nipah virus (NiV), a highly pathogenic paramyxovirus, causes a systemic infection in vivo and is able to replicate in cultured cells of many species and organs...
  76. Sohayati A, Hassan L, Sharifah S, Lazarus K, Zaini C, Epstein J, et al. Evidence for Nipah virus recrudescence and serological patterns of captive Pteropus vampyrus. Epidemiol Infect. 2011;139:1570-9 pubmed publisher
    This study aimed to describe the transmission dynamics, the serological and virus excretion patterns of Nipah virus (NiV) in Pteropus vampyrus bats. Bats in captivity were sampled every 7-21 days over a 1-year period...
  77. Rahman S, Hassan L, Epstein J, Mamat Z, Yatim A, Hassan S, et al. Risk Factors for Nipah virus infection among pteropid bats, Peninsular Malaysia. Emerg Infect Dis. 2013;19:51-60 pubmed publisher
    ..and longitudinal studies to determine the distribution of and risk factors for seropositivity to Nipah virus (NiV) among Pteropus vampyrus and P. hypomelanus bats in Peninsular Malaysia...
  78. Sleeman K, Bankamp B, Hummel K, Lo M, Bellini W, Rota P. The C, V and W proteins of Nipah virus inhibit minigenome replication. J Gen Virol. 2008;89:1300-8 pubmed publisher
    b>Nipah virus (NiV) is a recently emergent, highly pathogenic, zoonotic paramyxovirus of the genus Henipavirus...
  79. Geisbert T, Daddario DiCaprio K, Hickey A, Smith M, Chan Y, Wang L, et al. Development of an acute and highly pathogenic nonhuman primate model of Nipah virus infection. PLoS ONE. 2010;5:e10690 pubmed publisher
    b>Nipah virus (NiV) is an enigmatic emerging pathogen that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans...
  80. Gurley E, Montgomery J, Hossain M, Bell M, Azad A, Islam M, et al. Person-to-person transmission of Nipah virus in a Bangladeshi community. Emerg Infect Dis. 2007;13:1031-7 pubmed publisher
    ..Biologic specimens were tested for Nipah virus. Surfaces were evaluated for Nipah virus contamination by using reverse transcription-PCR (RT-PCR)...
  81. Berhane Y, Weingartl H, Lopez J, Neufeld J, Czub S, Embury Hyatt C, et al. Bacterial infections in pigs experimentally infected with Nipah virus. Transbound Emerg Dis. 2008;55:165-74 pubmed publisher
    b>Nipah virus (NiV; Paramyxoviridae) caused fatal encephalitis in humans during an outbreak in Malaysia in 1998/1999 after transmission from infected pigs...
  82. Rodriguez J, Horvath C. Host evasion by emerging paramyxoviruses: Hendra virus and Nipah virus v proteins inhibit interferon signaling. Viral Immunol. 2004;17:210-9 pubmed
    ..Hendra virus and Nipah virus (Henipaviruses) are recently emerged paramyxoviruses that are the causative agents of fatal disease outbreaks ..
  83. Wong K, Grosjean I, Brisson C, Blanquier B, Fevre Montange M, Bernard A, et al. A golden hamster model for human acute Nipah virus infection. Am J Pathol. 2003;163:2127-37 pubmed
    A predominantly pig-to-human zoonotic infection caused by the novel Nipah virus emerged recently to cause severe morbidity and mortality in both animals and man...
  84. Khan S, Gurley E, Hossain M, Nahar N, Sharker M, Luby S. A randomized controlled trial of interventions to impede date palm sap contamination by bats to prevent nipah virus transmission in Bangladesh. PLoS ONE. 2012;7:e42689 pubmed publisher
    Drinking raw date palm sap is a risk factor for human Nipah virus (NiV) infection. Fruit bats, the natural reservoir of NiV, commonly contaminate raw sap with saliva by licking date palm's sap producing surface...
  85. Wacharapluesadee S, Hemachudha T. Duplex nested RT-PCR for detection of Nipah virus RNA from urine specimens of bats. J Virol Methods. 2007;141:97-101 pubmed
    A method for duplex nested RT-PCR (nRT-PCR) with internal control (IC) for the detection of Nipah virus RNA is described. Incorporation of IC RNA distinguished false and true negative results...
  86. Walpita P, Barr J, Sherman M, Basler C, Wang L. Vaccine potential of Nipah virus-like particles. PLoS ONE. 2011;6:e18437 pubmed publisher
    b>Nipah virus (NiV) was first recognized in 1998 in a zoonotic disease outbreak associated with highly lethal febrile encephalitis in humans and a predominantly respiratory disease in pigs...
  87. Porotto M, Carta P, Deng Y, Kellogg G, Whitt M, Lu M, et al. Molecular determinants of antiviral potency of paramyxovirus entry inhibitors. J Virol. 2007;81:10567-74 pubmed
    Hendra virus (HeV) and Nipah virus (NiV) constitute the Henipavirus genus of paramyxoviruses, both fatal in humans and with the potential for subversion as agents of bioterrorism...
  88. McGinnes L, Pantua H, Laliberte J, Gravel K, Jain S, Morrison T. Assembly and biological and immunological properties of Newcastle disease virus-like particles. J Virol. 2010;84:4513-23 pubmed publisher
    ..The ectodomain of a foreign glycoprotein, the Nipah virus G protein, fused to the NDV HN protein cytoplasmic and transmembrane domains was incorporated into ND VLPs...
  89. Luby S, Hossain M, Gurley E, Ahmed B, Banu S, Khan S, et al. Recurrent zoonotic transmission of Nipah virus into humans, Bangladesh, 2001-2007. Emerg Infect Dis. 2009;15:1229-35 pubmed publisher
    ..Fruit bats are the reservoir host for Nipah virus. We identified 23 introductions of Nipah virus into human populations in central and northwestern Bangladesh ..
  90. Kulkarni S, Volchkova V, Basler C, Palese P, Volchkov V, Shaw M. Nipah virus edits its P gene at high frequency to express the V and W proteins. J Virol. 2009;83:3982-7 pubmed publisher
    b>Nipah virus (NiV) is predicted to encode four proteins from its P gene (P, V, W, and C) via mRNA editing and an alternate open reading frame...