newcastle disease virus

Summary

Summary: The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.

Top Publications

  1. Benfield C, Lyall J, Tiley L. The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity. PLoS ONE. 2010;5:e12151 pubmed publisher
    ..Here we report further studies to determine the antiviral potential of chicken Mx against Newcastle disease virus (NDV), an economically important cytoplasmic RNA virus of chickens, and Thogoto virus, an orthomyxovirus ..
  2. Wambura P, Kataga S. Putative protective antibody response following oral vaccination of multi-age free ranging helmeted guinea fowls (Numida meleagris) with Newcastle disease virus strain I-2 coated on oiled rice. Trop Anim Health Prod. 2011;43:99-102 pubmed publisher
    ..The findings from the present study showed that the I-2 virus coated on the oiled rice is safe, immunogenic and provoked production of protective antibody response following oral vaccination of helmeted guinea fowls...
  3. Maminiaina O, Gil P, Briand F, Albina E, Keita D, Andriamanivo H, et al. Newcastle disease virus in Madagascar: identification of an original genotype possibly deriving from a died out ancestor of genotype IV. PLoS ONE. 2010;5:e13987 pubmed publisher
    ..However, the potential implication in vaccination failures of specific amino acid substitutions predominantly found on surface-exposed epitopes of F and HN proteins is discussed...
  4. El Zowalaty M, Chander Y, Redig P, Abd El Latif H, El Sayed M, Goyal S. Selective isolation of Avian influenza virus (AIV) from cloacal samples containing AIV and Newcastle disease virus. J Vet Diagn Invest. 2011;23:330-2 pubmed
    ..addition to AIV, waterfowl are often coinfected with other viruses, such as the paramyxoviruses, of which Newcastle disease virus (NDV) is of particular importance because of the highly virulent nature of certain strains of this virus ..
  5. Bwala D, Clift S, Duncan N, Bisschop S, Oludayo F. Determination of the distribution of lentogenic vaccine and virulent Newcastle disease virus antigen in the oviduct of SPF and commercial hen using immunohistochemistry. Res Vet Sci. 2012;93:520-8 pubmed publisher
    ..ND) in South Africa has proved difficult since 2002 following the introduction of lineage 5d/VIId Newcastle disease virus (NDV) strain ("goose paramyxovirus" - GPMV) to which commercially available ND vaccines ..
  6. Diel D, Susta L, Cardenas Garcia S, Killian M, Brown C, Miller P, et al. Complete genome and clinicopathological characterization of a virulent Newcastle disease virus isolate from South America. J Clin Microbiol. 2012;50:378-87 pubmed publisher
    ..The disease is caused by Newcastle disease virus (NDV) or avian paramyxovirus type 1 (APMV-1), a negative-sense single-stranded RNA virus of the genus ..
  7. Sharma B, Pokhriyal M, Rai G, Saxena M, Ratta B, Chaurasia M, et al. Isolation of Newcastle disease virus from a non-avian host (sheep) and its implications. Arch Virol. 2012;157:1565-7 pubmed publisher
    b>Newcastle disease virus (NDV) is an avian virus that has not been isolated from naturally infected non-avian and non-human hosts except for one report in which it was isolated from cattle in 1952...
  8. Snoeck C, Owoade A, Couacy Hymann E, Alkali B, Okwen M, Adeyanju A, et al. High genetic diversity of Newcastle disease virus in poultry in West and Central Africa: cocirculation of genotype XIV and newly defined genotypes XVII and XVIII. J Clin Microbiol. 2013;51:2250-60 pubmed publisher
    Despite rampant Newcastle disease virus (NDV) outbreaks in Africa for decades, the information about the genetic characteristics of the virulent strains circulating in West and Central Africa is still scarce...
  9. Luo C, Qu H, Ma J, Wang J, Li C, Yang C, et al. Genome-wide association study of antibody response to Newcastle disease virus in chicken. BMC Genet. 2013;14:42 pubmed publisher
    ..However, the molecular basis of the variation in antibody response to Newcastle disease virus (NDV) is not clear...

More Information

Publications107 found, 100 shown here

  1. Arifin M, Mel M, Abdul Karim M, Ideris A. Production of Newcastle disease virus by Vero cells grown on cytodex 1 microcarriers in a 2-litre stirred tank bioreactor. J Biomed Biotechnol. 2010;2010:586363 pubmed publisher
    The aim of this study is to prepare a model for the production of Newcastle disease virus (NDV) lentogenic F strain using cell culture in bioreactor for live attenuated vaccine preparation...
  2. Estevez C, King D, Luo M, Yu Q. A single amino acid substitution in the haemagglutinin-neuraminidase protein of Newcastle disease virus results in increased fusion promotion and decreased neuraminidase activities without changes in virus pathotype. J Gen Virol. 2011;92:544-51 pubmed publisher
    Attachment of Newcastle disease virus (NDV) to the host cell is mediated by the haemagglutinin-neuraminidase (HN), a multifunctional protein that has receptor recognition, neuraminidase (NA) and fusion promotion activities...
  3. Ramp K, Skiba M, Karger A, Mettenleiter T, Römer Oberdörfer A. Influence of insertion site of the avian influenza virus haemagglutinin (HA) gene within the Newcastle disease virus genome on HA expression. J Gen Virol. 2011;92:355-60 pubmed publisher
    ..M), M and fusion protein (F), or F and haemagglutinin-neuraminidase protein (HN) genes of attenuated Newcastle disease virus (NDV) Clone 30...
  4. Tarnagda Z, Yougbare I, Kam A, Tahita M, Ouedraogo J. Prevalence of infectious bronchitis and Newcastle disease virus among domestic and wild birds in H5N1 outbreaks areas. J Infect Dev Ctries. 2011;5:565-70 pubmed
    ..This study aimed to determine the prevalence of avian influenza virus, infectious bronchitis virus, and Newcastle disease virus among domestic and wild birds in highly pathogenic avian influenza (HPAI) H5N1 outbreaks areas...
  5. Munir M, Cortey M, Abbas M, Qureshi Z, Afzal F, Shabbir M, et al. Biological characterization and phylogenetic analysis of a novel genetic group of Newcastle disease virus isolated from outbreaks in commercial poultry and from backyard poultry flocks in Pakistan. Infect Genet Evol. 2012;12:1010-9 pubmed publisher
    ..The characteristics of Newcastle disease virus (NDV) as virulent (F protein cleavage site, ICPI and MDT) in apparently healthy backyard poultry (BYP) ..
  6. Xiao S, Paldurai A, Nayak B, Samuel A, Bharoto E, Prajitno T, et al. Complete genome sequences of Newcastle disease virus strains circulating in chicken populations of Indonesia. J Virol. 2012;86:5969-70 pubmed publisher
    Eight highly virulent Newcastle disease virus (NDV) strains were isolated from vaccinated commercial chickens in Indonesia during outbreaks in 2009 and 2010...
  7. Steglich C, Grund C, Ramp K, Breithaupt A, Höper D, Keil G, et al. Chimeric newcastle disease virus protects chickens against avian influenza in the presence of maternally derived NDV immunity. PLoS ONE. 2013;8:e72530 pubmed publisher
    b>Newcastle disease virus (NDV), an avian paramyxovirus type 1, is a promising vector for expression of heterologous proteins from a variety of unrelated viruses including highly pathogenic avian influenza virus (HPAIV)...
  8. Hu J, Nistal Villán E, Voho A, Ganee A, Kumar M, Ding Y, et al. A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells. J Immunol. 2010;185:424-32 pubmed publisher
    Infection of human dendritic cells (DCs) by negative-strand RNA viruses, such as Newcastle disease virus, leads to the induction of the IFNbeta gene, IFNB1, through the activation of the RNA helicase RIG-I, which is encoded by DDX58...
  9. Wang K, Sui H, Li L, Li X, Wang L. [Anti-tumor immunity of Newcastle disease virus HN protein is influenced by differential subcellular targeting]. Zhongguo Fei Ai Za Zhi. 2010;13:773-6 pubmed publisher
    Hemagglutinin-neuraminidase (HN) protein of newcastle disease virus is an important immunogen for oncolysis...
  10. Kumar S, Nayak B, Collins P, Samal S. Evaluation of the Newcastle disease virus F and HN proteins in protective immunity by using a recombinant avian paramyxovirus type 3 vector in chickens. J Virol. 2011;85:6521-34 pubmed publisher
    b>Newcastle disease virus (NDV) belongs to serotype 1 of the avian paramyxoviruses (APMV-1) and causes severe disease in chickens. Current live attenuated NDV vaccines are not fully satisfactory...
  11. Hu Z, Hu S, Meng C, Wang X, Zhu J, Liu X. Generation of a genotype VII Newcastle disease virus vaccine candidate with high yield in embryonated chicken eggs. Avian Dis. 2011;55:391-7 pubmed
    To generate a genotype VII Newcastle disease virus (NDV) vaccine with high yield in embryonated chicken eggs, we selected genotype VII NDV strain JS5/05, which possesses a high virus titer in embryos as the parental virus...
  12. Yuan P, Swanson K, Leser G, Paterson R, Lamb R, Jardetzky T. Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk. Proc Natl Acad Sci U S A. 2011;108:14920-5 pubmed publisher
    ..Mutations of the Newcastle disease virus HN stalk region have been shown to affect both F activation and NA activities, but a structural basis for ..
  13. Dortmans J, Koch G, Rottier P, Peeters B. A comparative infection study of pigeon and avian paramyxovirus type 1 viruses in pigeons: evaluation of clinical signs, virus shedding and seroconversion. Avian Pathol. 2011;40:125-30 pubmed publisher
    ..The results show that the pigeon strain AV324 is not virulent for pigeons, but underlines the potential risk of poultry becoming infected by PPMV-1 shed by non-symptomatic pigeons...
  14. Molouki A, Hsu Y, Jahanshiri F, Abdullah S, Rosli R, Yusoff K. The matrix (M) protein of Newcastle disease virus binds to human bax through its BH3 domain. Virol J. 2011;8:385 pubmed publisher
    The underlying mechanisms by which Newcastle disease virus (NDV) kills cancer cells are still unclear...
  15. Kortekaas J, de Boer S, Kant J, Vloet R, Antonis A, Moormann R. Rift Valley fever virus immunity provided by a paramyxovirus vaccine vector. Vaccine. 2010;28:4394-401 pubmed publisher
    ..We here report the production of Gn and Gc by a recombinant vaccine strain of the avian paramyxovirus Newcastle disease virus (NDV) and demonstrate that intramuscular vaccination with this experimental NDV-based vector vaccine ..
  16. Ding Z, Cong Y, Chang S, Wang G, Wang Z, Zhang Q, et al. Genetic analysis of avian paramyxovirus-1 (Newcastle disease virus) isolates obtained from swine populations in China related to commonly utilized commercial vaccine strains. Virus Genes. 2010;41:369-76 pubmed publisher
    b>Newcastle disease virus (NDV) has been thought to only infect avian species...
  17. Ni J, Schirrmacher V, Fournier P. The hemagglutinin-neuraminidase gene of Newcastle Disease Virus: a powerful molecular adjuvant for DNA anti-tumor vaccination. Vaccine. 2010;28:6891-900 pubmed publisher
    ..this end, we prepared bicistronic DNA plasmids encoding the hemagglutinin-neuraminidase (HN) protein of Newcastle Disease Virus in addition to a tumor target antigen...
  18. Qiu X, Sun Q, Wu S, Dong L, Hu S, Meng C, et al. Entire genome sequence analysis of genotype IX Newcastle disease viruses reveals their early-genotype phylogenetic position and recent-genotype genome size. Virol J. 2011;8:117 pubmed publisher
  19. Ali R, Alabsi A, Ali A, Ideris A, Omar A, Yusoff K, et al. Cytolytic effects and apoptosis induction of Newcastle disease virus strain AF2240 on anaplastic astrocytoma brain tumor cell line. Neurochem Res. 2011;36:2051-62 pubmed publisher
    b>Newcastle disease virus (NDV) is a member of genus Avulavirus within the family Paramyxoviridae. Interest of using NDV as an anticancer agent has arisen from its ability to kill tumor cells with limited toxicity to normal cells...
  20. Snoeck C, Adeyanju A, Owoade A, Couacy Hymann E, Alkali B, Ottosson U, et al. Genetic diversity of newcastle disease virus in wild birds and pigeons in West Africa. Appl Environ Microbiol. 2013;79:7867-74 pubmed publisher
    In West and Central Africa, virulent Newcastle disease virus (NDV) strains of the recently identified genotypes XIV, XVII, and XVIII are enzootic in poultry, representing a considerable threat to the sector...
  21. Yacoub A, Leijon M, McMenamy M, Ullman K, McKillen J, Allan G, et al. Development of a novel real-time PCR-based strategy for simple and rapid molecular pathotyping of Newcastle disease virus. Arch Virol. 2012;157:833-44 pubmed publisher
    ..to simultaneously detect and to discriminate low-pathogenic lentogenic and virulent meso/velogenic Newcastle disease virus (NDV). The pathotyping is achieved by a three-step semi-nested PCR...
  22. Zhao K, Zhang Y, Zhang X, Li W, Shi C, Guo C, et al. Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles. Int J Nanomedicine. 2014;9:389-402 pubmed publisher
    Optimal preparation conditions of Newcastle disease virus (NDV) F gene deoxyribonucleic acid (DNA) vaccine encapsulated in chitosan nanoparticles (pFNDV-CS-NPs) were determined...
  23. Fan Y, Hu Y, Wang D, Guo Z, Zhao X, Guo L, et al. Epimedium polysaccharide and propolis flavone can synergistically stimulate lymphocyte proliferation in vitro and enhance the immune responses to ND vaccine in chickens. Int J Biol Macromol. 2010;47:87-92 pubmed publisher
    ..These results indicated that EP and PF possessed synergistically immune enhancement, EP-PF had the best efficacy, especially at medium dose, and would be expected to exploit into a new-type immunopotentiator...
  24. Munir M, Linde A, Zohari S, Ståhl K, Baule C, Holm K, et al. Complete genome analysis of an avian paramyxovirus type 1 strain isolated in 1994 from an asymptomatic black-headed gull (Larus ridibundus) in southern Sweden. Avian Dis. 2010;54:923-30 pubmed
    ..Waterfowl have been considered to act as a reservoir for APMV-1 and, therefore, it is important to broaden the knowledge of viruses circulating within this population. ..
  25. Susta L, Miller P, Afonso C, Brown C. Clinicopathological characterization in poultry of three strains of Newcastle disease virus isolated from recent outbreaks. Vet Pathol. 2011;48:349-60 pubmed publisher
    Newcastle disease is a severe threat to the poultry industry and is caused by Newcastle disease virus, a member of the genus Avulavirus, family Paramyxoviridae...
  26. Zhang W, Yin Z, Liu N, Yang T, Wang J, Bu Z, et al. DNA-chitosan nanoparticles improve DNA vaccine-elicited immunity against Newcastle disease virus through shuttling chicken interleukin-2 gene. J Microencapsul. 2010;27:693-702 pubmed publisher
    ..5. When pCAGG-ChIL2 CNPs were administered to chickens simultaneously with a DNA vaccine against Newcastle disease virus (NDV), haemagglutination inhibition antibody titers and serum interferon-? (IFN-?) levels were ..
  27. Gravel K, McGinnes L, Reitter J, Morrison T. The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein. J Virol. 2011;85:3486-97 pubmed publisher
    The role of specific sequences in the transmembrane (TM) domain of Newcastle disease virus (NDV) fusion (F) protein in the structure and function of this protein was assessed by replacing this domain with the F protein TM domains from ..
  28. Cattoli G, Susta L, Terregino C, Brown C. Newcastle disease: a review of field recognition and current methods of laboratory detection. J Vet Diagn Invest. 2011;23:637-56 pubmed publisher
  29. Hoque M, Burgess G, Karo Karo D, Cheam A, Skerratt L. Monitoring of wild birds for Newcastle disease virus in north Queensland, Australia. Prev Vet Med. 2012;103:49-62 pubmed publisher
    ..3 and 4). Our findings of higher prevalence in PWDs along with confirmation of class-one and class-two type NDV RNAs will significantly contribute to the design of surveillance programs for NDVs in northern Australia. ..
  30. Ramp K, Topfstedt E, Wäckerlin R, Höper D, Ziller M, Mettenleiter T, et al. Pathogenicity and immunogenicity of different recombinant Newcastle disease virus clone 30 variants after in ovo vaccination. Avian Dis. 2012;56:208-17 pubmed
    Even though Newcastle disease virus (NDV) live vaccine strains can be applied to 1-day-old chickens, they are pathogenic to chicken embryos when given in ovo 3 days before hatch...
  31. Zhang R, Wang X, Su J, Zhao J, Zhang G. Isolation and analysis of two naturally-occurring multi-recombination Newcastle disease viruses in China. Virus Res. 2010;151:45-53 pubmed publisher
    ..The potential role of swine-origin viruses in the evolution of virulent NDV warrants further investigation. ..
  32. Kong D, Wen Z, Su H, Ge J, Chen W, Wang X, et al. Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs. Virology. 2012;432:327-35 pubmed publisher
    ..Here, we generated recombinant avirulent Newcastle disease virus (NDV) LaSota strains expressing the NiV G and F proteins respectively (designated as rLa-NiVG and rLa-..
  33. Mansour M, Palese P, Zamarin D. Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells. J Virol. 2011;85:6015-23 pubmed publisher
    b>Newcastle disease virus (NDV) is a negative-sense RNA virus that has been shown to possess oncolytic activity...
  34. Zhang S, Wang X, Zhao C, Liu D, Hu Y, Zhao J, et al. Phylogenetic and pathotypical analysis of two virulent Newcastle disease viruses isolated from domestic ducks in China. PLoS ONE. 2011;6:e25000 pubmed publisher
    ..The present study suggests that more than one genotype of NDV circulates in domestic ducks in China and viral transmission may occur among chickens and domestic ducks. ..
  35. Biswas M, Johnson J, Kumar S, Parks G, Elankumarana S, SUBBIAH E. Incorporation of host complement regulatory proteins into Newcastle disease virus enhances complement evasion. J Virol. 2012;86:12708-16 pubmed publisher
    b>Newcastle disease virus (NDV), an avian paramyxovirus, is inherently tumor selective and is currently being considered as a clinical oncolytic virus and vaccine vector...
  36. Yuan P, Paterson R, Leser G, Lamb R, Jardetzky T. Structure of the ulster strain newcastle disease virus hemagglutinin-neuraminidase reveals auto-inhibitory interactions associated with low virulence. PLoS Pathog. 2012;8:e1002855 pubmed publisher
    ..HN can thereby directly influence virulence and in a subset of avirulent Newcastle disease virus (NDV) strains, such as NDV Ulster, HN must be proteolytically activated to remove a C-terminal extension ..
  37. Kattenbelt J, Stevens M, Selleck P, Gould A. Analysis of Newcastle disease virus quasispecies and factors affecting the emergence of virulent virus. Arch Virol. 2010;155:1607-15 pubmed publisher
    Genome sequence analysis of a number of avirulent field isolates of Newcastle disease virus revealed the presence of viruses (within their quasispecies) that contained virulent F0 sequences...
  38. Fu F, Zhao M, Yang Y, Tong G, Yang B, Song C, et al. Antiproliferative effect of newcastle disease virus strain D90 on human lung cancer cell line A549. Oncol Res. 2011;19:323-33 pubmed
    b>Newcastle disease virus (NDV) and variants of this virus have oncolytic properties and are potential anticancer agents...
  39. Li B, Fu D, Zhang Y, Xu Q, Ni L, Chang G, et al. Partial antiviral activities of the Asn631 chicken Mx against newcastle disease virus and vesicular stomatitis virus. Mol Biol Rep. 2012;39:8415-24 pubmed publisher
    ..The Mx protein was mainly located at the cytoplasm. The transfected cell cultures were challenged with newcastle disease virus (NDV) or vesicular stomatitis virus (VSV), cytopathic affect (CPE) inhibition assay showed that the times ..
  40. De Battisti C, Salomoni A, Ormelli S, Monne I, Capua I, Cattoli G. Rapid pathotyping of Newcastle Disease Virus by pyrosequencing. J Virol Methods. 2013;188:13-20 pubmed publisher
    b>Newcastle Disease Virus (NDV) is the only member of serotype 1 avian paramyxoviruses (APMV-1) that causes respiratory and neurological disease in chickens and other species of birds and can cause severe economic losses in the poultry ..
  41. DiNapoli J, Yang L, Samal S, Murphy B, Collins P, Bukreyev A. Respiratory tract immunization of non-human primates with a Newcastle disease virus-vectored vaccine candidate against Ebola virus elicits a neutralizing antibody response. Vaccine. 2010;29:17-25 pubmed publisher
    ..Here we developed a new vaccine candidate (NDV/GP) based on Newcastle disease virus (NDV), an avian paramyxovirus that is antigenically distinct from human viral pathogens and is highly ..
  42. Khattar S, Kumar S, Xiao S, Collins P, Samal S. Experimental infection of mice with avian paramyxovirus serotypes 1 to 9. PLoS ONE. 2011;6:e16776 pubmed publisher
    ..APMV-1, also called Newcastle disease virus, was shown to be attenuated in non-avian species and is being developed as a potential vector for human ..
  43. Hu J, Nudelman G, Shimoni Y, Kumar M, Ding Y, Lopez C, et al. Role of cell-to-cell variability in activating a positive feedback antiviral response in human dendritic cells. PLoS ONE. 2011;6:e16614 pubmed publisher
    ..The results suggest that large cell-to-cell variation plays an important role in the early innate immune response, and that the variability is essential for the efficient activation of the IFNB1 based feedback loop. ..
  44. Fournier P, Wilden H, Schirrmacher V. Importance of retinoic acid-inducible gene I and of receptor for type I interferon for cellular resistance to infection by Newcastle disease virus. Int J Oncol. 2012;40:287-98 pubmed publisher
    b>Newcastle disease virus (NDV) is an avian paramyxovirus with oncolytic properties which shows promising effects in the treatment of cancer...
  45. Perozo F, Marcano R, Afonso C. Biological and phylogenetic characterization of a genotype VII Newcastle disease virus from Venezuela: efficacy of field vaccination. J Clin Microbiol. 2012;50:1204-8 pubmed publisher
    Here we report the biological and molecular characterization of a virulent genotype VII Newcastle disease virus (NDV) circulating in Venezuela and the assessment of the vaccination efficacy under field conditions compared to controlled ..
  46. Munir M, Abbas M, Khan M, Zohari S, Berg M. Genomic and biological characterization of a velogenic Newcastle disease virus isolated from a healthy backyard poultry flock in 2010. Virol J. 2012;9:46 pubmed publisher
    b>Newcastle disease virus (NDV) causes severe and economically important disease in poultry around the globe. None of NDV strains in Pakistan have been completely characterized and the role of rural poultry in harbouring NDV is unclear...
  47. Porotto M, Salah Z, Devito I, Talekar A, Palmer S, Xu R, et al. The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion. J Virol. 2012;86:5730-41 pubmed publisher
    ..For Newcastle disease virus (NDV), one bifunctional site (site I) on HN's globular head can mediate both receptor binding and ..
  48. Snoeck C, Marinelli M, Charpentier E, Sausy A, Conzemius T, Losch S, et al. Characterization of newcastle disease viruses in wild and domestic birds in Luxembourg from 2006 to 2008. Appl Environ Microbiol. 2013;79:639-45 pubmed publisher
    b>Newcastle disease virus (NDV) is one of the most important viral diseases of birds. Wild birds constitute a natural reservoir of low-virulence viruses, while poultry are the main reservoir of virulent strains...
  49. Sarfati Mizrahi D, Lozano Dubernard B, Soto Priante E, Castro Peralta F, Flores Castro R, Loza Rubio E, et al. Protective dose of a recombinant Newcastle disease LaSota-avian influenza virus H5 vaccine against H5N2 highly pathogenic avian influenza virus and velogenic viscerotropic Newcastle disease virus in broilers with high maternal antibody levels. Avian Dis. 2010;54:239-41 pubmed
    The protective dose of a live recombinant LaSota Newcastle disease virus (NDV)-avian influenza H5 vaccine (rNDV-LS/AI-H5) was determined in broiler chickens with high levels of maternal antibodies against NDV and avian influenza virus (..
  50. Ge J, Tian G, Zeng X, Jiang Y, Chen H, Bua Z. Generation and evaluation of a Newcastle disease virus-based H9 avian influenza live vaccine. Avian Dis. 2010;54:294-6 pubmed
    Infection with H9 avian influenza virus (AIV) and Newcastle disease virus (NDV) are two important causes of egg drop in layer and breeder poultry, leading to severe economic loss in the industry...
  51. Ni J, Galani I, Cerwenka A, Schirrmacher V, Fournier P. Antitumor vaccination by Newcastle Disease Virus Hemagglutinin-Neuraminidase plasmid DNA application: changes in tumor microenvironment and activation of innate anti-tumor immunity. Vaccine. 2011;29:1185-93 pubmed publisher
    A plasmid encoding the Hemagglutinin-Neuraminidase (HN) protein of Newcastle Disease Virus (pHN) was tested for its capacity to stimulate innate anti-tumor activity in tumor-bearing mice...
  52. Cai S, Li J, Wong M, Jiao P, Fan H, Liu D, et al. Genetic characterization and evolutionary analysis of 4 Newcastle disease virus isolate full genomes from waterbirds in South China during 2003-2007. Vet Microbiol. 2011;152:46-54 pubmed publisher
    Complete genomes of four Newcastle disease virus (NDV) strains, isolated from ducks and wild birds in Guangdong province of China from 2003 to 2007, were sequenced and analyzed in this study...
  53. Wilden H, Schirrmacher V, Fournier P. Important role of interferon regulatory factor (IRF)-3 in the interferon response of mouse macrophages upon infection by Newcastle disease virus. Int J Oncol. 2011;39:493-504 pubmed publisher
    b>Newcastle disease virus (NDV) is an interesting agent for activating innate immune activity in macrophages including secretion of TNF-? and IFN-?, upregulation of TRAIL and activation of NF-?B and iNOS...
  54. Meng C, Zhou Z, Jiang K, Yu S, Jia L, Wu Y, et al. Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication. Arch Virol. 2012;157:1011-8 pubmed publisher
    b>Newcastle disease virus (NDV) can replicate in tumor cells and induce apoptosis in late stages of infection. However, the interaction between NDV and cells in early stages of infection is not well understood...
  55. Kumar R, Tiwari A, Chaturvedi U, Kumar G, Sahoo A, Rajmani R, et al. Velogenic newcastle disease virus as an oncolytic virotherapeutics: in vitro characterization. Appl Biochem Biotechnol. 2012;167:2005-22 pubmed publisher
    ..Oncolytic virotherapy seems to be a promising nonconventional way to treat cancers. Newcastle disease virus (NDV), a poultry virus, is nonpathogenic to human and domestic animals and has a long history of being ..
  56. Susta L, Cornax I, Diel D, Garcia S, Miller P, Liu X, et al. Expression of interferon gamma by a highly virulent strain of Newcastle disease virus decreases its pathogenicity in chickens. Microb Pathog. 2013;61-62:73-83 pubmed publisher
    The role of interferon gamma (IFN-γ) expression during Newcastle disease virus (NDV) infection in chickens is unknown...
  57. Miller P, Afonso C, El Attrache J, Dorsey K, Courtney S, Guo Z, et al. Effects of Newcastle disease virus vaccine antibodies on the shedding and transmission of challenge viruses. Dev Comp Immunol. 2013;41:505-13 pubmed publisher
    ..Traditionally, Newcastle disease virus (NDV) is recognized as having two major divisions represented by classes I and II, with class II being ..
  58. Lan D, Tang C, Li M, Yue H. Screening and identification of differentially expressed genes from chickens infected with Newcastle disease virus by suppression subtractive hybridization. Avian Pathol. 2010;39:151-9 pubmed publisher
    Newcastle disease is an important viral infectious disease caused by Newcastle disease virus (NDV), which leads to severe economic losses in the poultry industry worldwide...
  59. Susta L, Miller P, Afonso C, Estevez C, Yu Q, Zhang J, et al. Pathogenicity evaluation of different Newcastle disease virus chimeras in 4-week-old chickens. Trop Anim Health Prod. 2010;42:1785-95 pubmed publisher
    ..However, all birds developed histological evidence of encephalitis. The results suggest that the inherent virulence of Turkey North Dakota and California 2002 strains is due to more than the simple presence of their F and HN genes. ..
  60. Su B, Shen P, Hung L, Huang J, Yin H, Lee L. Potentiation of cell-mediated immune responses against recombinant HN protein of Newcastle disease virus by recombinant chicken IL-18. Vet Immunol Immunopathol. 2011;141:283-92 pubmed publisher
    In this study, recombinant fowlpox viruses (rFPV/HN) expressing Newcastle disease virus (NDV) HN protein and rFPV/HN/chIL-18 co-expressing chicken IL-18 (chIL-18) and HN protein have been constructed and characterized...
  61. Samal S, Kumar S, Khattar S, Samal S. A single amino acid change, Q114R, in the cleavage-site sequence of Newcastle disease virus fusion protein attenuates viral replication and pathogenicity. J Gen Virol. 2011;92:2333-8 pubmed publisher
    A key determinant of Newcastle disease virus (NDV) virulence is the amino acid sequence at the fusion (F) protein cleavage site...
  62. Zoth S, Gómez E, Carballeda J, Carrillo E, Berinstein A. Expression of a secreted version of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus: its evaluation as a diagnostic reagent. J Vet Diagn Invest. 2011;23:519-23 pubmed publisher
    The hemagglutinin-neuraminidase (HN) glycoprotein of Newcastle disease virus (NDV) constitutes, together with the fusion glycoprotein, the main surface antigen of this avian pathogen, which causes a highly contagious disease, relevant ..
  63. Tirumurugaan K, Kapgate S, Vinupriya M, Vijayarani K, Kumanan K, Elankumaran S. Genotypic and pathotypic characterization of Newcastle disease viruses from India. PLoS ONE. 2011;6:e28414 pubmed publisher
    b>Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry in most parts of the world...
  64. Diel D, da Silva L, Liu H, Wang Z, Miller P, Afonso C. Genetic diversity of avian paramyxovirus type 1: proposal for a unified nomenclature and classification system of Newcastle disease virus genotypes. Infect Genet Evol. 2012;12:1770-9 pubmed publisher
    The avian paramyxovirus type 1 (APMV-1), or Newcastle disease virus (NDV), comprise a diverse group of viruses with a single-stranded, negative-sense RNA genome...
  65. Samal S, Khattar S, Paldurai A, Palaniyandi S, Zhu X, Collins P, et al. Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity. J Virol. 2013;87:10083-93 pubmed publisher
    The Newcastle disease virus (NDV) fusion protein (F) mediates fusion of viral and host cell membranes and is a major determinant of NDV pathogenicity...
  66. Paldurai A, Kumar S, Nayak B, Samal S. Complete genome sequence of highly virulent neurotropic Newcastle disease virus strain Texas GB. Virus Genes. 2010;41:67-72 pubmed publisher
    b>Newcastle disease virus (NDV) strain Texas GB is a highly virulent neurotropic virus that is used as a standard vaccine challenge virus in the U.S...
  67. Kim D, Martinez Sobrido L, Choi C, Petroff N, Garcia Sastre A, Niewiesk S, et al. Induction of type I interferon secretion through recombinant Newcastle disease virus expressing measles virus hemagglutinin stimulates antibody secretion in the presence of maternal antibodies. J Virol. 2011;85:200-7 pubmed publisher
    ..In order to provide such a stimulus, we generated a recombinant Newcastle disease virus (NDV) expressing the MV hemagglutinin (NDV-H)...
  68. Mohamed M, Kumar S, Paldurai A, Samal S. Sequence analysis of fusion protein gene of Newcastle disease virus isolated from outbreaks in Egypt during 2006. Virol J. 2011;8:237 pubmed publisher
    b>Newcastle disease virus represents APMV-1 and is the most characterized among all APMV types. The F protein cleavage site sequence is a well-characterized determinant of NDV pathogenicity in chickens...
  69. Ge J, Wang X, Tao L, Wen Z, Feng N, Yang S, et al. Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats. J Virol. 2011;85:8241-52 pubmed publisher
    Effective, safe, and affordable rabies vaccines are still being sought. Newcastle disease virus (NDV), an avian paramyxovirus, has shown promise as a vaccine vector for mammals...
  70. Ge S, Zheng D, Zhao Y, Liu H, Liu W, Sun Q, et al. Evaluating viral interference between Influenza virus and Newcastle disease virus using real-time reverse transcription-polymerase chain reaction in chicken eggs. Virol J. 2012;9:128 pubmed publisher
    ..allantoic cavity inoculations of Specific-pathogen-free (SPF) chicken eggs with Influenza virus (AIV) and Newcastle disease virus (NDV) demonstrated that the interaction of AIV and NDV during co-infection was variable...
  71. Munir M, Shabbir M, Yaqub T, Shabbir M, Mukhtar N, Khan M, et al. Complete genome sequence of a velogenic neurotropic avian paramyxovirus 1 isolated from peacocks (Pavo cristatus) in a wildlife park in Pakistan. J Virol. 2012;86:13113-4 pubmed publisher
    ..The work presented here is the first complete genome sequence of any APMV-1 isolate from wild birds in the region and therefore highlights the need for increased awareness and surveillance in such bird species. ..
  72. Chellappa M, Dey S, Gaikwad S, Kataria J, Vakharia V. Complete genome sequence of Newcastle disease virus mesogenic vaccine strain R2B from India. J Virol. 2012;86:13814-5 pubmed publisher
    Mesogenic vaccine strains of Newcastle disease virus (NDV) are widely used in many countries of Asia and Africa to control the Newcastle disease of poultry...
  73. Zhao K, Chen G, Shi X, Gao T, Li W, Zhao Y, et al. Preparation and efficacy of a live newcastle disease virus vaccine encapsulated in chitosan nanoparticles. PLoS ONE. 2012;7:e53314 pubmed publisher
    Newcastle disease (ND) is a highly contagious viral disease of poultry caused by pathogenic strains of the Newcastle disease virus (NDV). Live NDV vaccines are administered by drinking water, eyedrops or coarse aerosol spray...
  74. Mase M, Murayama K, Karino A, Inoue T. Analysis of the fusion protein gene of Newcastle disease viruses isolated in Japan. J Vet Med Sci. 2011;73:47-54 pubmed
  75. Khattar S, Samal S, DeVico A, Collins P, Samal S. Newcastle disease virus expressing human immunodeficiency virus type 1 envelope glycoprotein induces strong mucosal and serum antibody responses in Guinea pigs. J Virol. 2011;85:10529-41 pubmed publisher
    ..We therefore sought to evaluate the induction of systemic and mucosal immune responses by the use of Newcastle disease virus (NDV) as a vaccine vector...
  76. Dortmans J, Koch G, Rottier P, Peeters B. Virulence of Newcastle disease virus: what is known so far?. Vet Res. 2011;42:122 pubmed publisher
    In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV)...
  77. Lwelamira J. Phenotypic and genetic parameters for body weights and antibody response against Newcastle disease virus (NDV) vaccine for Kuchi chicken ecotype of Tanzania under extensive management. Trop Anim Health Prod. 2012;44:1529-34 pubmed publisher
  78. Wei D, Sun N, Nan G, Wang Y, Liu H, Peeters B, et al. Construction of recombinant Newcastle disease virus Italien strain for oncolytic virotherapy of tumors. Hum Gene Ther. 2012;23:700-10 pubmed publisher
    b>Newcastle disease virus (NDV) is a naturally oncolytic virus that has been shown to be safe and effective for cancer therapy...
  79. Mirza A, Iorio R. A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation. J Virol. 2013;87:8813-5 pubmed publisher
    b>Newcastle disease virus (NDV)-induced membrane fusion requires formation of a complex between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins...
  80. Kim S, Wanasen N, Paldurai A, Xiao S, Collins P, Samal S. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS ONE. 2013;8:e74022 pubmed publisher
    Virulent strains of Newcastle disease virus (NDV) can cause devastating disease in chickens worldwide. Although the current vaccines are substantially effective, they do not completely prevent infection, virus shedding and disease...
  81. Swanson K, Wen X, Leser G, Paterson R, Lamb R, Jardetzky T. Structure of the Newcastle disease virus F protein in the post-fusion conformation. Virology. 2010;402:372-9 pubmed publisher
    ..Previous studies of the Newcastle disease virus, human parainfluenza virus 3 and parainfluenza virus 5 F proteins revealed differences in the pre- and ..
  82. Rue C, Susta L, Cornax I, Brown C, Kapczynski D, Suarez D, et al. Virulent Newcastle disease virus elicits a strong innate immune response in chickens. J Gen Virol. 2011;92:931-9 pubmed publisher
    b>Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry worldwide...
  83. Nidzworski D, Rabalski L, Gromadzka B. Detection and differentiation of virulent and avirulent strains of Newcastle disease virus by real-time PCR. J Virol Methods. 2011;173:144-9 pubmed publisher
    ..based on the melting curve SYBR Green I real-time PCR analysis was developed to detect and differentiate Newcastle disease virus (NDV) strains...
  84. Bian J, Wang K, Kong X, Liu H, Chen F, Hu M, et al. Caspase- and p38-MAPK-dependent induction of apoptosis in A549 lung cancer cells by Newcastle disease virus. Arch Virol. 2011;156:1335-44 pubmed publisher
    b>Newcastle disease virus (NDV) has a potential oncolytic effect due to its ability to induce apoptosis in tumor cells...
  85. Harmsen M, Antonis A, Moormann R, Kortekaas J. Parenteral vaccination of mammalian livestock with Newcastle disease virus-based vector vaccines offers optimal efficacy and safety. Bioeng Bugs. 2011;2:58-62 pubmed publisher
    b>Newcastle disease virus (NDV) is an avian virus that is being evaluated as a vaccine vector for the delivery of foreign genes in mammals. The use of NDV as a vaccine vector in these species offers two major advantages...
  86. Wu Y, Zhang X, Wang X, Wang L, Hu S, Liu X, et al. Apoptin enhances the oncolytic properties of Newcastle disease virus. Intervirology. 2012;55:276-86 pubmed publisher
    Naturally occurring strains of Newcastle disease virus (NDV) have demonstrated the potential to kill cancer cells in both preclinical and clinical studies...
  87. Mase M, Kanehira K. Simple differentiation of avirulent and virulent strains of avian paramyxovirus serotype-1 (Newcastle disease virus) by PCR and restriction endonuclease analysis in Japan. J Vet Med Sci. 2012;74:1661-4 pubmed
    To differentiate the avirulent from virulent strains of avian paramyxovirus serotype-1 (APMV-1, Newcastle disease virus), PCR and restriction endonuclease analysis (REA) was employed...
  88. Dai Y, Liu M, Cheng X, Shen X, Wei Y, Zhou S, et al. Infectivity and pathogenicity of Newcastle disease virus strains of different avian origin and different virulence for mallard ducklings. Avian Dis. 2013;57:8-14 pubmed
    Experimental infections of Newcastle disease virus (NDV) strains of different avian origin and different virulence in mallard (Anas platyrhynchos) ducklings were undertaken to evaluate infectivity and pathogenicity of NDV for ducks and ..
  89. Maamary J, Array F, Gao Q, Garcia Sastre A, Steinman R, Palese P, et al. Newcastle disease virus expressing a dendritic cell-targeted HIV gag protein induces a potent gag-specific immune response in mice. J Virol. 2011;85:2235-46 pubmed publisher
    ..Recombinant Newcastle disease virus (rNDV) stands out as a vaccine vector since it has a proven safety profile in humans, it is a potent ..
  90. Munir M, Linde A, Zohari S, Ståhl K, Baule C, Engström B, et al. Whole genome sequencing and characterization of a virulent Newcastle disease virus isolated from an outbreak in Sweden. Virus Genes. 2011;43:261-71 pubmed publisher
    In this study, the complete genome sequence of a Newcastle disease virus (NDV) isolate collected from an outbreak in 1995 in chickens was fully characterized and compared with other NDV sequences...
  91. Song Q, Cao Y, Li Q, Gu M, Zhong L, Hu S, et al. Artificial recombination may influence the evolutionary analysis of Newcastle disease virus. J Virol. 2011;85:10409-14 pubmed publisher
    The recombination rate in Newcastle disease virus (NDV) was as high as 10% in RDP analysis with full-length NDV genome sequences available in GenBank...
  92. Ch ng W, Stanbridge E, Ong K, Wong K, Yusoff K, Shafee N. Partial protection against enterovirus 71 (EV71) infection in a mouse model immunized with recombinant Newcastle disease virus capsids displaying the EV71 VP1 fragment. J Med Virol. 2011;83:1783-91 pubmed publisher
    ..Hence, a candidate vaccine construct, containing recombinant Newcastle disease virus capsids that display an EV71 VP1 fragment (NPt-VP1(1-100) ) protein, was evaluated in a mouse model of ..