Summary: A family of spherical viruses, of the order MONONEGAVIRALES, somewhat larger than the orthomyxoviruses, and containing single-stranded RNA. Subfamilies include PARAMYXOVIRINAE and PNEUMOVIRINAE.

Top Publications

  1. Iwane M, Edwards K, Szilagyi P, Walker F, Griffin M, Weinberg G, et al. Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics. 2004;113:1758-64 pubmed
    ..The enhanced use of influenza vaccine and the development of RSV and PIV vaccines have the potential to reduce markedly the pediatric morbidity from ARIs. ..
  2. Philbey A, Kirkland P, Ross A, Davis R, Gleeson A, Love R, et al. An apparently new virus (family Paramyxoviridae) infectious for pigs, humans, and fruit bats. Emerg Infect Dis. 1998;4:269-71 pubmed
    We isolated an apparently new virus in the family Paramyxoviridae from stillborn piglets with deformities at a piggery in New South Wales, Australia...
  3. Bhella D, Ralph A, Murphy L, Yeo R. Significant differences in nucleocapsid morphology within the Paramyxoviridae. J Gen Virol. 2002;83:1831-9 pubmed
    Nucleocapsid (N) proteins from representative viruses of three genera within the Paramyxoviridae were expressed in insect cells using recombinant baculoviruses...
  4. Nagai Y, Kato A. Accessory genes of the paramyxoviridae, a large family of nonsegmented negative-strand RNA viruses, as a focus of active investigation by reverse genetics. Curr Top Microbiol Immunol. 2004;283:197-248 pubmed
    The Paramyxoviridae, a large family of nonsegmented negative-strand RNA viruses, comprises several genera each containing important human and animal pathogens...
  5. Pomeroy L, Bjørnstad O, Holmes E. The evolutionary and epidemiological dynamics of the paramyxoviridae. J Mol Evol. 2008;66:98-106 pubmed publisher
  6. Goodbourn S, Randall R. The regulation of type I interferon production by paramyxoviruses. J Interferon Cytokine Res. 2009;29:539-47 pubmed publisher
  7. McCarthy A, Goodman S. Reassessing conflicting evolutionary histories of the Paramyxoviridae and the origins of respiroviruses with Bayesian multigene phylogenies. Infect Genet Evol. 2010;10:97-107 pubmed publisher
  8. Wang L, Yu M, Hansson E, Pritchard L, Shiell B, Michalski W, et al. The exceptionally large genome of Hendra virus: support for creation of a new genus within the family Paramyxoviridae. J Virol. 2000;74:9972-9 pubmed
    ..The causative agent was a new member of the family Paramyxoviridae. The virus was originally called Equine morbillivirus but was renamed Hendra virus (HeV) when molecular ..
  9. van den Hoogen B, de Jong J, Groen J, Kuiken T, de Groot R, Fouchier R, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7:719-24 pubmed
    ..Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years. ..

More Information

Publications104 found, 100 shown here

  1. Wise M, Sellers H, Alvarez R, Seal B. RNA-dependent RNA polymerase gene analysis of worldwide Newcastle disease virus isolates representing different virulence types and their phylogenetic relationship with other members of the paramyxoviridae. Virus Res. 2004;104:71-80 pubmed
    ..A comparison of the NDV L coding sequences to other Paramyxoviridae illustrated the unique clustering of the avian-specific paramyxoviruses, further justifying the newly created ..
  2. Andrejeva J, Childs K, Young D, Carlos T, Stock N, Goodbourn S, et al. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A. 2004;101:17264-9 pubmed
  3. Jack P, Boyle D, Eaton B, Wang L. The complete genome sequence of J virus reveals a unique genome structure in the family Paramyxoviridae. J Virol. 2005;79:10690-700 pubmed publisher
    ..genome sequence of J-V has now been determined, revealing a genome structure unique within the family Paramyxoviridae. At 18,954 nucleotides (nt), the J-V genome is the largest paramyxovirus genome sequenced to date, containing ..
  4. Hughes A. Relaxation of purifying selection on live attenuated vaccine strains of the family Paramyxoviridae. Vaccine. 2009;27:1685-90 pubmed publisher
  5. Pees M, Schmidt V, Marschang R, Heckers K, Krautwald Junghanns M. Prevalence of viral infections in captive collections of boid snakes in Germany. Vet Rec. 2010;166:422-5 pubmed publisher
    ..A significant correlation was found between the origin of the snake and the presence of PMV, and between the presence of remarkable microbiological findings and husbandry conditions...
  6. Chen S, Short J, Young D, Killip M, Schneider M, Goodbourn S, et al. Heterocellular induction of interferon by negative-sense RNA viruses. Virology. 2010;407:247-55 pubmed publisher
    ..We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells. ..
  7. Hyatt A, Selleck P. Ultrastructure of equine morbillivirus. Virus Res. 1996;43:1-15 pubmed
    ..ultrastructure of the virus and the intracellular virus-specific structures are characteristic for the family Paramyxoviridae. Cytoplasmic nucleocapsids were observed within the infected cells monolayers, endothelial cells (lung) of ..
  8. Langedijk J, Daus F, van Oirschot J. Sequence and structure alignment of Paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin. J Virol. 1997;71:6155-67 pubmed
    ..sites, active-site residues, and disulfide bridges agree with the proposed 3D structure of HN and H of the Paramyxoviridae. Moreover, details of the modelled H protein predict previously undescribed enzymatic activity...
  9. Chant K, Chan R, Smith M, Dwyer D, Kirkland P. Probable human infection with a newly described virus in the family Paramyxoviridae. The NSW Expert Group. Emerg Infect Dis. 1998;4:273-5 pubmed
    After an apparently new virus in the family Paramyxoviridae was isolated from pigs in August 1997, an investigation was carried out to assess its risk for humans...
  10. Fontana J, Bankamp B, Rota P. Inhibition of interferon induction and signaling by paramyxoviruses. Immunol Rev. 2008;225:46-67 pubmed publisher
    The family Paramyxoviridae comprises a diverse group of viruses that includes several important human and veterinary pathogens...
  11. Drexler J, Corman V, Müller M, Maganga G, Vallo P, Binger T, et al. Bats host major mammalian paramyxoviruses. Nat Commun. 2012;3:796 pubmed publisher
    The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses...
  12. Zeller H, Karabatsos N, Calisher C, Digoutte J, Murphy F, Shope R. Electron microscopy and antigenic studies of uncharacterized viruses. I. Evidence suggesting the placement of viruses in families Arenaviridae, Paramyxoviridae, or Poxviridae. Arch Virol. 1989;108:191-209 pubmed
    ..that 20 are members of the virus family Bunyaviridae, 20 Rhabdoviridae, 14 Reoviridae, one Togaviridae, one Paramyxoviridae (Mapuera virus, from a bat), and one Poxviridae (Yoka virus, from mosquitoes)...
  13. Seal B, King D, Meinersmann R. Molecular evolution of the Newcastle disease virus matrix protein gene and phylogenetic relationships among the paramyxoviridae. Virus Res. 2000;66:1-11 pubmed
    ..closely related to morbilliviruses and not with their current designated category, the rubulaviruses among the Paramyxoviridae. Consequently, avian paramyxoviruses should have their own taxonomic subfamily among the Paramyxovirinae.
  14. Giuliani A, Tomasi M. Recurrence quantification analysis reveals interaction partners in paramyxoviridae envelope glycoproteins. Proteins. 2002;46:171-6 pubmed
    ..The cooperation between HN and F in the fusion process is thus demonstrated by a bioinformatic, purely sequence-dependent, perspective. ..
  15. Springfeld C, von Messling V, Tidona C, Darai G, Cattaneo R. Envelope targeting: hemagglutinin attachment specificity rather than fusion protein cleavage-activation restricts Tupaia paramyxovirus tropism. J Virol. 2005;79:10155-63 pubmed publisher
    ..Targeting competence and the absence of antibodies in humans define the TPMV envelope as a module to be adapted for ferrying ribonucleocapsids of oncolytic viruses and gene delivery vectors...
  16. Childs K, Andrejeva J, Randall R, Goodbourn S. Mechanism of mda-5 Inhibition by paramyxovirus V proteins. J Virol. 2009;83:1465-73 pubmed publisher
    ..In contrast, V proteins cannot bind to RIG-I and consequently have no effect on the ability of RIG-I to bind dsRNA or to form oligomers. ..
  17. Lau S, Woo P, Wong B, Wong A, Tsoi H, Wang M, et al. Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China. Virology. 2010;404:106-16 pubmed publisher
    ..Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes...
  18. Westover K, Hughes A. Molecular evolution of viral fusion and matrix protein genes and phylogenetic relationships among the Paramyxoviridae. Mol Phylogenet Evol. 2001;21:128-34 pubmed
    Phylogenetic relationships among the Paramyxoviridae, a broad family of viruses whose members cause devastating diseases of wildlife, livestock, and humans, were examined with both fusion (F) and matrix (M) protein-coding sequences...
  19. Ramachandran A, Horvath C. Paramyxovirus disruption of interferon signal transduction: STATus report. J Interferon Cytokine Res. 2009;29:531-7 pubmed publisher
    ..These viral proteins have distinct means of targeting STATs, resulting in a variety of negative effects on STATs and their signal transduction. Recent developments in understanding STAT targeting will be reviewed. ..
  20. Kitagawa Y, Sakai M, Funayama M, Itoh M, Gotoh B. Human Metapneumovirus M2-2 Protein Acts as a Negative Regulator of Alpha Interferon Production by Plasmacytoid Dendritic Cells. J Virol. 2017;91: pubmed publisher
    ..b>IMPORTANCE The family Paramyxoviridae is divided into two subfamilies, the Paramyxovirinae and the Pneumovirinae Members of the ..
  21. Adisen E, Onder M. Acral manifestations of viral infections. Clin Dermatol. 2017;35:40-49 pubmed publisher
    ..for cutaneous viral diseases, but other virus families, such as Adenoviridae, Togaviridae, Parvoviridae, Paramyxoviridae, Flaviviridae, and Hepadnaviridae, can also infect the skin...
  22. Dawes B, Kalveram B, Ikegami T, Juelich T, Smith J, Zhang L, et al. Favipiravir (T-705) protects against Nipah virus infection in the hamster model. Sci Rep. 2018;8:7604 pubmed publisher
    ..Favipiravir has demonstrated efficacy against a broad spectrum of RNA viruses, including members of the Paramyxoviridae, Filoviridae, Arenaviridae families, and the Bunyavirales order...
  23. Smeele Z, Ainley D, Varsani A. Viruses associated with Antarctic wildlife: From serology based detection to identification of genomes using high throughput sequencing. Virus Res. 2018;243:91-105 pubmed publisher
    ..showed exposure to viruses in the families Birnaviridae, Flaviviridae, Herpesviridae, Orthomyxoviridae and Paramyxoviridae circulating in seals (Phocidae), penguins (Spheniscidae), petrels (Procellariidae) and skuas (Stercorariidae)...
  24. Stehle T, Casasnovas J. Specificity switching in virus-receptor complexes. Curr Opin Struct Biol. 2009;19:181-8 pubmed publisher
    ..Moreover, it also has relevance for the design and use of viruses as gene delivery vehicles with altered properties as well as for the identification of target viral epitopes of new vaccines. ..
  25. Conzelmann K. Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA viruses. J Virol. 2005;79:5241-8 pubmed
  26. van Diepen A, Brand H, Sama I, Lambooy L, van den Heuvel L, van der Well L, et al. Quantitative proteome profiling of respiratory virus-infected lung epithelial cells. J Proteomics. 2010;73:1680-93 pubmed publisher
    ..By 2-D DIGE analyses we have gathered information on the induction of apoptosis by respiratory viruses in A549 cells. ..
  27. Boyoglu Barnum S, Todd S, Meng J, Barnum T, Chirkova T, Haynes L, et al. Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective. J Virol. 2017;91: pubmed publisher
    Respiratory syncytial virus (RSV) belongs to the family Paramyxoviridae and is the single most important cause of serious lower respiratory tract infections in young children, yet no highly effective treatment or vaccine is ..
  28. Pearson H. Mystery virus slow to yield its identity as patient numbers rise. Nature. 2003;422:364 pubmed
  29. Loo Y, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez Sobrido L, et al. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol. 2008;82:335-45 pubmed
    ..the innate immune signaling requirements of representative viruses of the Flaviviridae, Orthomyxoviridae, Paramyxoviridae, and Reoviridae for RIG-I, MDA5, and interferon promoter-stimulating factor 1 (IPS-1)...
  30. Delmas O, Assenberg R, Grimes J, Bourhy H. The structure of the nucleoprotein binding domain of lyssavirus phosphoprotein reveals a structural relationship between the N-RNA binding domains of Rhabdoviridae and Paramyxoviridae. RNA Biol. 2010;7:322-7 pubmed
    ..We also review the numerous other functions of this domain and more generally of the phosphoprotein. ..
  31. Beaty S, Park A, Won S, Hong P, Lyons M, Vigant F, et al. Efficient and Robust Paramyxoviridae Reverse Genetics Systems. mSphere. 2017;2: pubmed publisher
    The notoriously low efficiency of Paramyxoviridae reverse genetics systems has posed a limiting barrier to the study of viruses in this family...
  32. Newman J, Riggs J, Surman S, McAuliffe J, Mulaikal T, Collins P, et al. Generation of recombinant human parainfluenza virus type 1 vaccine candidates by importation of temperature-sensitive and attenuating mutations from heterologous paramyxoviruses. J Virol. 2004;78:2017-28 pubmed
    ..Thus, importation of attenuating mutations from heterologous viruses is an effective means for rapidly identifying mutations that attenuate HPIV1 and for generating live-attenuated HPIV1 vaccine candidates...
  33. Cosby S, Weir L. Measles vaccination: Threat from related veterinary viruses and need for continued vaccination post measles eradication. Hum Vaccin Immunother. 2017;: pubmed publisher
    Measles virus (MV) is the only human virus within the morbillivirus genus of the Paramyxoviridae. The veterinary members are canine distemper virus (CDV), peste des petits ruminants virus (PPRV), Rinderpest Virus (RPV) as well as the ..
  34. Berg M, Hjertner B, Moreno Lopez J, Linne T. The P gene of the porcine paramyxovirus LPMV encodes three possible polypeptides P, V and C: the P protein mRNA is edited. J Gen Virol. 1992;73 ( Pt 5):1195-200 pubmed
    ..The third ORF has the capacity to encode a protein of 126 amino acids, which may resemble the C proteins found in some paramyxoviruses. The ORF starts from an AUG codon down-stream of the first AUG codon of the P/V ORF. ..
  35. Yang L, Sanchez A, Ward J, Murphy B, Collins P, Bukreyev A. A paramyxovirus-vectored intranasal vaccine against Ebola virus is immunogenic in vector-immune animals. Virology. 2008;377:255-64 pubmed publisher
  36. Tsurudome M, Ito M, Nishio M, Nakahashi M, Kawano M, Komada H, et al. Identification of domains on the fusion (F) protein trimer that influence the hemagglutinin-neuraminidase specificity of the f protein in mediating cell-cell fusion. J Virol. 2011;85:3153-61 pubmed publisher
  37. Tsurudome M, Bando H, Nishio M, Iwamoto Y, Kawano M, Kondo K, et al. Antigenic and structural properties of a paramyxovirus simian virus 41 (SV41) reveal a close relationship with human parainfluenza type 2 virus. Virology. 1990;179:738-48 pubmed
    ..The SV41 HN is also related to the SV5 HN (51.3% identity); thus, the SV41 HN is phylogenetically situated between the PIV2 and SV5 HNs. These results indicate that SV41 is the virus closest to PIV2 at present. ..
  38. Lee J, Prussia A, Paal T, White L, Snyder J, Plemper R. Functional interaction between paramyxovirus fusion and attachment proteins. J Biol Chem. 2008;283:16561-72 pubmed publisher
    ..Their localization in structural models of F and H suggests that placement in particular of F residue 233 in close proximity to the 110-114 region of H is structurally conceivable. ..
  39. Cleveland S, Davies J, McClure M. A bioinformatics approach to the structure, function, and evolution of the nucleoprotein of the order mononegavirales. PLoS ONE. 2011;6:e19275 pubmed publisher
    ..nucleoprotein (N) sequences from four viral families (Bornaviridae, Filoviridae, Rhabdoviridae, and Paramyxoviridae) we predict the regions of protein disorder, intra-residue contact and co-evolving residues...
  40. Qiu S, Ogino M, Luo M, Ogino T, Green T. Structure and Function of the N-Terminal Domain of the Vesicular Stomatitis Virus RNA Polymerase. J Virol. 2016;90:715-24 pubmed publisher
    ..L proteins from members of the Rhabdoviridae, Paramyxoviridae, and Filoviridae share sequence and predicted secondary structure homology...
  41. Bergsland E, Venook A. Shedding old paradigms: developing viruses to treat cancer. J Clin Oncol. 2002;20:2220-2 pubmed
  42. Seth S, Vincent A, Compans R. Mutations in the cytoplasmic domain of a paramyxovirus fusion glycoprotein rescue syncytium formation and eliminate the hemagglutinin-neuraminidase protein requirement for membrane fusion. J Virol. 2003;77:167-78 pubmed
    ..These results demonstrate that an elongated CT of a paramyxovirus F protein interferes with membrane fusion in a sequence-dependent manner. ..
  43. Enserink M. Infectious diseases. A second suspect in the global mystery outbreak. Science. 2003;299:1963 pubmed
  44. Kawano M, Tsurudome M, Oki N, Nishio M, Komada H, Matsumura H, et al. Sequence determination of the P gene of simian virus 41: presence of irregular deletions near the RNA-editing sites of paramyxoviruses. J Gen Virol. 1993;74 ( Pt 5):911-6 pubmed
    ..Alignment of the SV41 P and V proteins with those of nine other paramyxoviruses demonstrated that irregular gaps were present around the RNA-editing sites. ..
  45. Franke J, Batts W, Ahne W, Kurath G, Winton J. Sequence motifs and prokaryotic expression of the reptilian paramyxovirus fusion protein. Arch Virol. 2006;151:449-64 pubmed
    ..gene of all isolates contained conserved motifs homologous to those described for other members of the family Paramyxoviridae including: signal peptide, transmembrane domain, furin cleavage site, fusion peptide, N-linked glycosylation ..
  46. Connolly S, Leser G, Yin H, Jardetzky T, Lamb R. Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy. Proc Natl Acad Sci U S A. 2006;103:17903-8 pubmed
    ..The reactivity of the F protein with conformation-specific mAbs and peptide binding suggest that soluble F-GCNt and membrane-bound F proteins refold through a comparable pathway. ..
  47. Smith E, Gregory S, Tamm L, Creamer T, Dutch R. Role of sequence and structure of the Hendra fusion protein fusion peptide in membrane fusion. J Biol Chem. 2012;287:30035-48 pubmed publisher
  48. Thomas S, Lamb R, Paterson R. Two mRNAs that differ by two nontemplated nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5. Cell. 1988;54:891-902 pubmed
    ..An open reading frame that contains this cysteine-rich region exists in all other paramyxovirus "P" gene sequences examined, which suggests that it may have important biological significance. ..
  49. Galabov A, Nikolaeva L, Todorova D, Milkova T. Antiviral activity of cholesteryl esters of cinnamic acid derivatives. Z Naturforsch C. 1998;53:883-7 pubmed
    ..e. Picornaviridae, Orthomyxoviridae, Paramyxoviridae and Herpesviridae.
  50. Allender M, Mitchell M, Phillips C, Gruszynski K, Beasley V. Hematology, plasma biochemistry, and antibodies to select viruses in wild-caught Eastern massasauga rattlesnakes (Sistrurus catenatus catenatus) from Illinois. J Wildl Dis. 2006;42:107-14 pubmed
    ..None of the snakes tested (n=21) were seropositive for WNV, whereas all (n=20) were seropositive for OPMV. ..
  51. Qiao D, Janke B, Elankumaran S. Complete genome sequence and pathogenicity of two swine parainfluenzavirus 3 isolates from pigs in the United States. J Virol. 2010;84:686-94 pubmed publisher
    ..These two viruses were mildly pathogenic to conventionally reared pigs, and results from a limited enzyme-linked immunosorbent assay-based serosurvey of swine farms in Minnesota and Iowa in 2007 and 2008 were negative...
  52. Panzera Y, Sarute N, Iraola G, Hernández M, Pérez R. Molecular phylogeography of canine distemper virus: Geographic origin and global spreading. Mol Phylogenet Evol. 2015;92:147-54 pubmed publisher
    Canine distemper virus (CDV) (Paramyxoviridae-Morbillivirus) is a worldwide spread virus causing a fatal systemic disease in a broad range of carnivore hosts...
  53. Adu Gyamfi E, Kim L, Jardetzky T, Lamb R. Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion. J Virol. 2016;90:9172-81 pubmed publisher
    The Paramyxoviridae comprise a large family of enveloped, negative-sense, single-stranded RNA viruses with significant economic and public health implications...
  54. Prpić J, Keros T, Balija M, Forcic D, Jemersic L. First recorded case of paramyxovirus infection introduced into a healthy snake collection in Croatia. BMC Vet Res. 2017;13:95 pubmed publisher
    ..We stress the need for veterinary health control and monitoring of snakes prior to transportation as well as implementing obligatory quarantine measures to minimize the risk of infection among newly established snake groups. ..
  55. Bajimaya S, Hayashi T, Takimoto T. Rescue of Sendai Virus from Cloned cDNA. Methods Mol Biol. 2017;1602:103-110 pubmed publisher
    ..As a prototypic member of the family Paramyxoviridae, SeV has been characterized well, and these studies revealed numerous traits of paramyxovirus biology...
  56. Martínez Gil L, Vera Velasco N, Mingarro I. Exploring the Human-Nipah Virus Protein-Protein Interactome. J Virol. 2017;91: pubmed publisher
    Nipah virus is an emerging, highly pathogenic, zoonotic virus of the Paramyxoviridae family...
  57. Tsurudome M, Bando H, Kawano M, Matsumura H, Komada H, Nishio M, et al. Transcripts of simian virus 41 (SV41) matrix gene are exclusively dicistronic with the fusion gene which is also transcribed as a monocistron. Virology. 1991;184:93-100 pubmed
  58. Cosby S, McQuaid S, Taylor M, Bailey M, Rima B, Martin S, et al. Examination of eight cases of multiple sclerosis and 56 neurological and non-neurological controls for genomic sequences of measles virus, canine distemper virus, simian virus 5 and rubella virus. J Gen Virol. 1989;70 ( Pt 8):2027-36 pubmed
    ..This result was confirmed using biotinylated probes prepared against the measles virus N genomic sequence. No hybridization was found in any of the MS or control cases using any of the other viral genome-specific probes...
  59. Takimoto T, Portner A. Molecular mechanism of paramyxovirus budding. Virus Res. 2004;106:133-45 pubmed
    ..The structural organization of the virion and the functions of the M protein clearly indicate that this protein orchestrates the budding of paramyxovirus. ..
  60. Schatzberg S, Li Q, Porter B, Barber R, Claiborne M, Levine J, et al. Broadly reactive pan-paramyxovirus reverse transcription polymerase chain reaction and sequence analysis for the detection of Canine distemper virus in a case of canine meningoencephalitis of unknown etiology. J Vet Diagn Invest. 2009;21:844-9 pubmed
    ..This case illustrates the utility of broadly reactive PCR and sequence analysis for the identification of pathogens in diseases with unknown etiology. ..
  61. Majumdar T, Dhar J, Patel S, Kondratov R, Barik S. Circadian transcription factor BMAL1 regulates innate immunity against select RNA viruses. Innate Immun. 2017;23:147-154 pubmed publisher
    ..BMAL1-deficient cells are significantly more susceptible to infection by two major respiratory viruses of the Paramyxoviridae family, namely RSV and PIV3...
  62. Duhaut P, Bosshard S, Calvet A, Pinede L, Demolombe Rague S, Dumontet C, et al. Giant cell arteritis, polymyalgia rheumatica, and viral hypotheses: a multicenter, prospective case-control study. Groupe de Recherche sur l'Artérite à Cellules Géantes. J Rheumatol. 1999;26:361-9 pubmed
    ..Our findings suggest that reinfection with HPIV type 1 is associated with the onset of GCA in a subset of patients, particularly in cases with positive TA biopsy. ..
  63. Chatziandreou N, Young D, Andrejeva J, Goodbourn S, Randall R. Differences in interferon sensitivity and biological properties of two related isolates of simian virus 5: a model for virus persistence. Virology. 2002;293:234-42 pubmed
  64. Peisajovich S, Shai Y. New insights into the mechanism of virus-induced membrane fusion. Trends Biochem Sci. 2002;27:183-90 pubmed
    ..with whole viruses, as well as protein dissection, has suggested that the fusion glycoprotein (F) from Paramyxoviridae, a family that includes major human pathogens, has two hydrophobic segments, termed fusion peptides...
  65. File T. Viral respiratory tract infections: increasing importance and a new pathogen. Curr Opin Infect Dis. 2003;16:125-7 pubmed
  66. Arden K, McErlean P, Nissen M, Sloots T, Mackay I. Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections. J Med Virol. 2006;78:1232-40 pubmed
  67. Yaiw K, Ong K, Chua K, Bingham J, Wang L, Shamala D, et al. Tioman virus infection in experimentally infected mouse brain and its association with apoptosis. J Virol Methods. 2007;143:140-6 pubmed
    ..J., Gleeson, A.B., Love, R.J., Daniels, P.W., Gould, A.R., Hyatt, A.D., 1998. An apparently new virus (family Paramyxoviridae) infectious for pigs, humans, and fruit bats. Emerg. Infect. Dis...
  68. Singleton R, Bulkow L, Miernyk K, DeByle C, Pruitt L, Hummel K, et al. Viral respiratory infections in hospitalized and community control children in Alaska. J Med Virol. 2010;82:1282-90 pubmed publisher
    ..Rhinovirus and adenovirus were detected in two-thirds of hospitalized children, but their frequent detection in control children made their role in respiratory hospitalization uncertain. ..
  69. Ogawa M, Mutsuga N, Tsurudome M, Kawano M, Matsumura H, Kusagawa S, et al. Nucleotide sequence analysis of the simian virus 41 gene encoding the large (L) protein and construction of a phylogenetic tree for the L proteins of paramyxoviruses. J Gen Virol. 1992;73 ( Pt 10):2743-50 pubmed
    ..The intergenic, and gene-start and -end sequences of SV41, HPIV-2 and SV5 are shown. ..
  70. Kimber K, Kollias G, Dubovi E. Serologic survey of selected viral agents in recently captured wild North American river otters (Lontra canadensis). J Zoo Wildl Med. 2000;31:168-75 pubmed
    ..Stress-associated humoral immune suppression could have altered serologic profiles, especially in otters exposed to dogs after trapping but before venipuncture...
  71. Bose S, Banerjee A. Innate immune response against nonsegmented negative strand RNA viruses. J Interferon Cytokine Res. 2003;23:401-12 pubmed
    ..the innate immune response, in the context of infection by nonsegmented negative strand RNA viruses of the Paramyxoviridae family...
  72. McIntosh K, McAdam A. Human metapneumovirus--an important new respiratory virus. N Engl J Med. 2004;350:431-3 pubmed
  73. Dong Y, Fang F. [To understand common pathogenic viruses in pediatrics from the perspectives of viral taxonomy]. Zhonghua Er Ke Za Zhi. 2004;42:7-9 pubmed
  74. Takaoka A, Yanai H. Interferon signalling network in innate defence. Cell Microbiol. 2006;8:907-22 pubmed
    ..Further comprehensive understanding of IFN signalling may offer a better direction to unravelling the complex signalling networks in the host defence system, and may contribute to their more effective therapeutic applications. ..
  75. Juozapaitis M, Serva A, Kucinskaite I, Zvirbliene A, Slibinskas R, Staniulis J, et al. Generation of menangle virus nucleocapsid-like particles in yeast Saccharomyces cerevisiae. J Biotechnol. 2007;130:441-7 pubmed outbreak of severe reproductive disease in pigs, is a novel member of the genus Rubulavirus in the family Paramyxoviridae. Although successfully eradicated from the affected piggery, fruit bats are considered to be the natural ..
  76. Freiberg A, Dolores L, Enterlein S, Flick R. Establishment and characterization of plasmid-driven minigenome rescue systems for Nipah virus: RNA polymerase I- and T7-catalyzed generation of functional paramyxoviral RNA. Virology. 2008;370:33-44 pubmed
    ..we report the development and optimization of two minigenome rescue systems for Nipah virus, a member of the Paramyxoviridae family...
  77. Samuel A, Kumar S, Madhuri S, Collins P, Samal S. Complete sequence of the genome of avian paramyxovirus type 9 and comparison with other paramyxoviruses. Virus Res. 2009;142:10-8 pubmed publisher
    ..amino acid sequences of APMV-9 proteins with the cognate proteins of viruses of all five genera of family Paramyxoviridae showed that APMV-9 is more closely related to APMV-1 than to other APMVs...
  78. van Boheemen S, Bestebroer T, Verhagen J, Osterhaus A, Pas S, Herfst S, et al. A family-wide RT-PCR assay for detection of paramyxoviruses and application to a large-scale surveillance study. PLoS ONE. 2012;7:e34961 pubmed publisher
    ..have developed a RT-PCR assay consisting of a single degenerate primer set, able to detect all members of the Paramyxoviridae family including all virus genera within the subfamilies Paramyxovirinae and Pneumovirinae...
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    ..analyses of the complete N, M, F and L genes support the clustering of this virus within the family Paramyxoviridae but outside both of the current subfamilies: Paramyxovirinae and Pneumovirinae...
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    ..We discuss the importance of innate responses in DC following paramyxovirus infection and their consequences for the ability to mount and maintain antiviral T cells. ..
  81. Wansley E, Parks G. Naturally occurring substitutions in the P/V gene convert the noncytopathic paramyxovirus simian virus 5 into a virus that induces alpha/beta interferon synthesis and cell death. J Virol. 2002;76:10109-21 pubmed
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    ..Although the conserved region I of NDV (avulavirus) promoter appears to be more similar to that of Sendai virus (SeV) (respirovirus), conserved region II is analogous to that of rubulaviruses. ..
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    ..of the predicted amino acid sequences of strain Yucaipa proteins with the cognate proteins of viruses of all of the five genera of family Paramyxoviridae showed that APMV-2 strain Yucaipa is more closely related to APMV-6 than APMV-1.
  85. Schnepf N, Resche Rigon M, Chaillon A, Scemla A, Gras G, Semoun O, et al. High burden of non-influenza viruses in influenza-like illness in the early weeks of H1N1v epidemic in France. PLoS ONE. 2011;6:e23514 pubmed publisher
    ..Clinical observations are of little help to recognise myxovirus infection and implement appropriate prevention measures. The limited use of molecular tools underestimates the role of other common pathogens...
  86. Rodriguez K, Horvath C. Amino acid requirements for MDA5 and LGP2 recognition by paramyxovirus V proteins: a single arginine distinguishes MDA5 from RIG-I. J Virol. 2013;87:2974-8 pubmed publisher
    ..These findings indicate that paramyxoviruses use a single amino acid to distinguish MDA5 from RIG-I and have evolved distinct contact sites for LGP2 interference. ..
  87. Hudacek A, Navaratnarajah C, Cattaneo R. Development of measles virus-based shielded oncolytic vectors: suitability of other paramyxovirus glycoproteins. Cancer Gene Ther. 2013;20:109-16 pubmed publisher
    ..Ultimately, this interferes with applications for oncolytic virotherapy. Alternative strategies for the generation of shielded MV are discussed. ..
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    ..The presence of PPIV-1 in mainly respiratory samples suggests a possible association with respiratory disease, similar to HPIV-1 and SeV. ..
  89. Sasaki M, Muleya W, Ishii A, Orba Y, Hang Ombe B, Mweene A, et al. Molecular epidemiology of paramyxoviruses in Zambian wild rodents and shrews. J Gen Virol. 2014;95:325-30 pubmed publisher
    ..Our findings suggest the circulation of previously unknown paramyxoviruses in African rodents and shrews, and provide new information regarding the geographical distribution and genetic diversity of paramyxoviruses. ..
  90. Yamaguchi M, Kitagawa Y, Zhou M, Itoh M, Gotoh B. An anti-interferon activity shared by paramyxovirus C proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon induction. FEBS Lett. 2014;588:28-34 pubmed publisher
    ..This anti-IFN activity of C protein is shared across genera of the Paramyxovirinae, and thus appears to play an important role in paramyxovirus immune evasion...
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    ..It is suggested that, like the influenza virus neuraminidase, hemagglutinin-neuraminidase of paramyxoviruses is oriented with its N terminus inserted into the membrane. ..
  92. Michalski W, Crameri G, Wang L, Shiell B, Eaton B. The cleavage activation and sites of glycosylation in the fusion protein of Hendra virus. Virus Res. 2000;69:83-93 pubmed
    Hendra virus (HeV) is an unclassified member of the Paramyxoviridae family that causes systemic infections in humans, horses, cats, guinea pigs and flying foxes...