marburgvirus

Summary

Summary: A genus in the family FILOVIRIDAE consisting of one species (Lake Victoria marburgvirus) with several strains. The genus shows no antigenic cross-reactivity with EBOLAVIRUS.

Top Publications

  1. Amman B, Nyakarahuka L, McElroy A, Dodd K, Sealy T, Schuh A, et al. Marburgvirus resurgence in Kitaka Mine bat population after extermination attempts, Uganda. Emerg Infect Dis. 2014;20:1761-4 pubmed publisher
  2. Leendertz S, Gogarten J, Düx A, Calvignac Spencer S, Leendertz F. Assessing the Evidence Supporting Fruit Bats as the Primary Reservoirs for Ebola Viruses. Ecohealth. 2016;13:18-25 pubmed publisher
  3. Wijesinghe K, Urata S, Bhattarai N, Kooijman E, Gerstman B, Chapagain P, et al. Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry. J Biol Chem. 2017;292:6108-6122 pubmed publisher
    ..Taken together, we propose a model by which association of the mVP40 dimer with the anionic plasma membrane facilitates assembly of mVP40 oligomers. ..
  4. Nyakarahuka L, Skjerve E, Nabadda D, Sitali D, Mumba C, Mwiine F, et al. Knowledge and attitude towards Ebola and Marburg virus diseases in Uganda using quantitative and participatory epidemiology techniques. PLoS Negl Trop Dis. 2017;11:e0005907 pubmed publisher
    ..The public health sector should enhance this community knowledge gap to empower them more by supplying educational materials for epidemic preparedness in future using appropriate communication channels as proposed by the communities. ..
  5. Feldmann H, Bugany H, Mahner F, Klenk H, Drenckhahn D, Schnittler H. Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages. J Virol. 1996;70:2208-14 pubmed
    ..Clin. Invest. 19:1301-1309, 1993) and monocytes/macrophages and the permeability-increasing effect of virus-induced cytokine release provide the first experimental data for a novel concept in the pathogenesis of viral hemorrhagic fever. ..
  6. Weiwei G, Xuexing Z, Chong W, Yongkun Z, Qi W, Hualei W, et al. Marburg virus-like particles produced in insect cells induce neutralizing antibodies in rhesus macaques. J Med Virol. 2017;89:2069-2074 pubmed publisher
    ..These data indicate that MARV VLPs mixed with adjuvant PCP-II have excellent immunogenicity in rhesus macaques and may be a promising candidate vaccine against MARV. ..
  7. Zhao Y, Ren J, Harlos K, Jones D, Zeltina A, Bowden T, et al. Toremifene interacts with and destabilizes the Ebola virus glycoprotein. Nature. 2016;535:169-172 pubmed publisher
    ..Thus, these complex structures reveal the mechanism of inhibition and may guide the development of more powerful anti-EBOV drugs. ..
  8. Liu B, Dong S, Li G, Wang W, Liu X, Wang Y, et al. Structural Insight into Nucleoprotein Conformation Change Chaperoned by VP35 Peptide in Marburg Virus. J Virol. 2017;91: pubmed publisher
    ..Finally, we discussed the high conservation and critical role of the VP35 binding pocket and its potential use for therapeutic development. ..
  9. Zhu T, Song H, Peng R, Shi Y, Qi J, Gao G. Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide Reveals a Conserved Drug Target for Filovirus. J Virol. 2017;91: pubmed publisher
    ..Our results expand our knowledge of filovirus NP-VP35 interactions and provide more details for therapeutic intervention. ..

More Information

Publications10

  1. Stonier S, Herbert A, Kuehne A, Sobarzo A, Habibulin P, Dahan C, et al. Marburg virus survivor immune responses are Th1 skewed with limited neutralizing antibody responses. J Exp Med. 2017;214:2563-2572 pubmed publisher
    ..These results warrant serious consideration for any vaccine or therapeutic that seeks to be broadly protective, as different filoviruses may require different immune responses to achieve immunity. ..