borna disease virus

Summary

Summary: A species in the genus Bornavirus, family BORNAVIRIDAE, causing a rare and usually fatal encephalitic disease in horses and other domestic animals and possibly deer. Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in Europe, N. Africa, and the Near East.

Top Publications

  1. Taieb O, Baleyte J, Mazet P, Fillet A. Borna disease virus and psychiatry. Eur Psychiatry. 2001;16:3-10 pubmed
    b>Borna disease virus (BDV), a noncytolytic neurotropic nonsegmented negative-stranded RNA virus with a wide geographic distribution, infects several vertebrate animal species and causes an immune-mediated central nervous system (CNS) ..
  2. Carbone K, Duchala C, Griffin J, Kincaid A, Narayan O. Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J Virol. 1987;61:3431-40 pubmed
    b>Borna disease virus is an uncharacterized agent that causes sporadic but fatal neurological disease in horses and sheep in Europe...
  3. Volmer R, Prat C, Le Masson G, Garenne A, Gonzalez Dunia D. Borna disease virus infection impairs synaptic plasticity. J Virol. 2007;81:8833-7 pubmed
    The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood...
  4. FESCHOTTE C. Virology: Bornavirus enters the genome. Nature. 2010;463:39-40 pubmed publisher
  5. Dauphin G, Legay V, Sailleau C, Smondack S, Hammoumi S, Zientara S. Evidence of Borna disease virus genome detection in French domestic animals and in foxes (Vulpes vulpes). J Gen Virol. 2001;82:2199-204 pubmed
    b>Borna disease virus (BDV) is an enveloped, non-segmented negative-stranded RNA virus which belongs to the Bornaviridae family. BDV is an aetiological agent of encephalitis in horses, sheep and several other vertebrate species...
  6. Durrwald R, Kolodziejek J, Muluneh A, Herzog S, Nowotny N. Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations. Microbes Infect. 2006;8:917-29 pubmed
    ..The etiologic agent is Borna disease virus (BDV), thus far the only member of the family Bornaviridae...
  7. Wensman J, Jäderlund K, Gustavsson M, Hansson Hamlin H, Karlstam E, Lilliehöök I, et al. Markers of Borna disease virus infection in cats with staggering disease. J Feline Med Surg. 2012;14:573-82 pubmed publisher
    b>Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease...
  8. Fukuda K, Takahashi K, Iwata Y, Mori N, Gonda K, Ogawa T, et al. Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan. J Clin Microbiol. 2001;39:419-29 pubmed
    The involvement of Borna disease virus (BDV) in psychiatric diseases in humans remains controversial...
  9. Williams B, Yaddanapudi K, Hornig M, Lipkin W. Spatiotemporal analysis of purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection. J Virol. 2007;81:2675-87 pubmed
    Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life...

More Information

Publications104 found, 100 shown here

  1. Pleschka S, Staeheli P, Kolodziejek J, Richt J, Nowotny N, Schwemmle M. Conservation of coding potential and terminal sequences in four different isolates of Borna disease virus. J Gen Virol. 2001;82:2681-90 pubmed
    We determined the complete nucleotide sequences of two poorly characterized strains of Borna disease virus (BDV) and compared them to reference strains V and He/80...
  2. Lancaster K, Dietz D, Moran T, Pletnikov M. Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus. Behav Brain Res. 2007;176:141-8 pubmed
    ..In this report, we briefly review our animal model of ASD based on neonatal Borna disease virus (BDV) infection and present new data about abnormal social interaction in adult BDV-infected rats...
  3. Heinrich A, Adamaszek M. Anti-Borna disease virus antibody responses in psychiatric patients: long-term follow up. Psychiatry Clin Neurosci. 2010;64:255-61 pubmed publisher
    Data suggesting a pathogenetic role for Borna disease virus (BDV) in neuropsychiatric diseases are still inconclusive and it is unknown whether humans become persistently infected or clear the virus infection...
  4. Hausmann J, Sauder C, Wasmer M, Lu B, Staeheli P. Neurological disorder after Borna disease virus infection in the absence of either interferon-gamma, Fas, inducible NO synthase, or chemokine receptor CXCR3. Viral Immunol. 2004;17:79-85 pubmed
    b>Borna disease virus (BDV) can induce severe neurological disorder in Lewis rats and MRL mice. Antiviral CD8 T cells have been shown to be the mediators of disease in these animals...
  5. Prat C, Schmid S, Farrugia F, Cenac N, Le Masson G, Schwemmle M, et al. Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. PLoS Pathog. 2009;5:e1000425 pubmed publisher
    ..b>Borna disease virus (BDV) represents an attractive model system to analyze the molecular mechanisms whereby a virus can persist ..
  6. Kamitani W, Shoya Y, Kobayashi T, Watanabe M, Lee B, Zhang G, et al. Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1. J Virol. 2001;75:8742-51 pubmed
    The Borna disease virus (BDV) p24 phosphoprotein is an abundant protein in BDV-infected cultured cells and animal brains...
  7. Bajramovic J, Münter S, Syan S, Nehrbass U, Brahic M, Gonzalez Dunia D. Borna disease virus glycoprotein is required for viral dissemination in neurons. J Virol. 2003;77:12222-31 pubmed
    b>Borna disease virus (BDV) is a nonsegmented negative-strand RNA virus with a tropism for neurons. Infection with BDV causes neurological diseases in a wide variety of animal species...
  8. Planz O, Pleschka S, Wolff T. Borna disease virus: a unique pathogen and its interaction with intracellular signalling pathways. Cell Microbiol. 2009;11:872-9 pubmed publisher
    b>Borna disease virus (BDV) is a neurotropic RNA virus that establishes non-cytolytic persistent infection in the central nervous system of warm-blooded animals...
  9. Berg M, Ehrenborg C, Blomberg J, Pipkorn R, Berg A. Two domains of the Borna disease virus p40 protein are required for interaction with the p23 protein. J Gen Virol. 1998;79 ( Pt 12):2957-63 pubmed
    b>Borna disease virus (BDV) has five major open reading frames, which encode the proteins p40, p23, gp18, p57 and p190. By analogy with other negative-strand RNA viruses, p40 is a putative nucleoprotein and p23 is a putative phosphoprotein...
  10. Hofer M, Hausmann J, Staeheli P, Pagenstecher A. Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice. Am J Pathol. 2004;165:949-58 pubmed
    ..Infection with noncytolytic Borna disease virus (BDV) did not affect wild-type mice but accelerated disease of IL-12 transgenic mice...
  11. Nunes S, Itano E, Amarante M, Reiche E, Miranda H, de Oliveira C, et al. RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives. J Clin Lab Anal. 2008;22:314-20 pubmed publisher
    ..Detection of p24 RNA from Borna disease virus (BDV) by the reverse transcriptase polymerase chain reaction in patients with schizophrenia, ..
  12. Rauer M, Pagenstecher A, Schulte Mönting J, Sauder C. Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation. J Neurovirol. 2002;8:168-79 pubmed
    Infection of adult rats with Borna disease virus (BDV) causes CD8 T cell-mediated meningoencephalitis. Previously, we described a complex pattern of chemokine gene expression in the central nervous system (CNS) of such rats...
  13. Hilbe M, Herrsche R, Kolodziejek J, Nowotny N, Zlinszky K, Ehrensperger F. Shrews as reservoir hosts of borna disease virus. Emerg Infect Dis. 2006;12:675-7 pubmed
    b>Borna disease virus (BDV) is the causative agent of severe T-cell-mediated meningoencephalitis in horses, sheep, and other animal species in central Europe...
  14. Honda T, Fujino K, Okuzaki D, Ohtaki N, Matsumoto Y, Horie M, et al. Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express Borna disease virus phosphoprotein. J Virol. 2011;85:4567-71 pubmed publisher
    In a previous study, we demonstrated that transgenic mice that express Borna disease virus (BDV) phosphoprotein (P) in astrocytes show striking neurobehavioral abnormalities resembling those in BDV-infected animals...
  15. Wolff T, Heins G, Pauli G, Burger R, Kurth R. Failure to detect Borna disease virus antigen and RNA in human blood. J Clin Virol. 2006;36:309-11 pubmed
    b>Borna disease virus (BDV) is the etiological agent of a rare progressive meningoencephalitis that affects mostly horses and sheep...
  16. Sauder C, Hallensleben W, Pagenstecher A, Schneckenburger S, Biro L, Pertlik D, et al. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. J Virol. 2000;74:9267-80 pubmed
    b>Borna disease virus (BDV) causes CD8(+) T-cell-mediated meningoencephalitis in immunocompetent mice and rats, thus providing a valuable animal model for studying the mechanisms of virus-induced central nervous system (CNS) ..
  17. Geib T, Sauder C, Venturelli S, Hässler C, Staeheli P, Schwemmle M. Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components. J Virol. 2003;77:4283-90 pubmed
    ..We present evidence for superinfection exclusion in brains of Borna disease virus (BDV)-infected rats and in persistently infected Vero cells, and we suggest that acquired resistance to BDV ..
  18. Kolodziejek J, Durrwald R, Herzog S, Ehrensperger F, Lussy H, Nowotny N. Genetic clustering of Borna disease virus natural animal isolates, laboratory and vaccine strains strongly reflects their regional geographical origin. J Gen Virol. 2005;86:385-98 pubmed
    The aim of this study was to gain more detailed insights into the genetic evolution and variability of Borna disease virus (BDV)...
  19. Perez M, Watanabe M, Whitt M, de La Torre J. N-terminal domain of Borna disease virus G (p56) protein is sufficient for virus receptor recognition and cell entry. J Virol. 2001;75:7078-85 pubmed
    b>Borna disease virus (BDV) surface glycoprotein (GP) (p56) has a predicted molecular mass of 56 kDa. Due to extensive posttranslational glycosylation the protein migrates as a polypeptide of 84 kDa (gp84)...
  20. Duplan V, Suberbielle E, Napper C, Joly E, Saoudi A, Gonzalez Dunia D. Tracking antigen-specific CD8+ T cells in the rat using MHC class I multimers. J Immunol Methods. 2007;320:30-9 pubmed
    ..We produced a rat RT1(l) Pro5 MHC Pentamer combined with the immunodominant peptide for Borna disease virus (BDV), in order to study the characteristics of the antiviral CD8(+) T cell response...
  21. de la Torre J. Reverse-genetic approaches to the study of Borna disease virus. Nat Rev Microbiol. 2006;4:777-83 pubmed
    b>Borna disease virus (BDV) is an enveloped virus that has a non-segmented, negative-strand RNA genome with the characteristic organization of the mononegaviruses...
  22. Poenisch M, Wille S, Ackermann A, Staeheli P, Schneider U. The X protein of borna disease virus serves essential functions in the viral multiplication cycle. J Virol. 2007;81:7297-9 pubmed
    The X gene of Borna disease virus (BDV) encodes a nonstructural 10-kDa protein that can interact with viral polymerase cofactor P, thus regulating polymerase activity. It remained unknown whether X is essential for virus multiplication...
  23. Hayashi Y, Horie M, Daito T, Honda T, Ikuta K, Tomonaga K. Heat shock cognate protein 70 controls Borna disease virus replication via interaction with the viral non-structural protein X. Microbes Infect. 2009;11:394-402 pubmed publisher
    b>Borna disease virus (BDV) is a non-segmented, negative-sense RNA virus and has the property of persistently infecting the cell nucleus...
  24. Schneider U, Naegele M, Staeheli P, Schwemmle M. Active borna disease virus polymerase complex requires a distinct nucleoprotein-to-phosphoprotein ratio but no viral X protein. J Virol. 2003;77:11781-9 pubmed
    Analysis of the composition and regulation of the Borna disease virus (BDV) polymerase complex has so far been limited by the lack of a functional assay...
  25. Clemente R, de la Torre J. Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing of the virus surface glycoprotein. J Virol. 2007;81:5968-77 pubmed
    b>Borna disease virus (BDV) is an enveloped virus with a nonsegmented negative-strand RNA genome whose organization is characteristic of Mononegavirales...
  26. de La Torre J, Gonzalez Dunia D, Cubitt B, Mallory M, Mueller Lantzsch N, Grasser F, et al. Detection of borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients. Virology. 1996;223:272-82 pubmed
    b>Borna disease virus (BDV) causes a central nervous system disease in several vertebrate species which is characterized by behavioral disturbances...
  27. Allmang U, Hofer M, Herzog S, Bechter K, Staeheli P. Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value. Mol Psychiatry. 2001;6:329-33 pubmed
    b>Borna disease virus (BDV) can induce neurological disease in animals...
  28. Cotto E, Neau D, Cransac Neau M, Auriacombe M, Pellegrin J, Ragnaud J, et al. Borna disease virus RNA in immunocompromised patients in southwestern France. J Clin Microbiol. 2003;41:5577-81 pubmed
    b>Borna disease virus (BDV) is a neurotropic RNA virus with a wide host range. Human infections, although controversial, have been described in Europe, Asia, and the United States...
  29. Eickmann M, Kiermayer S, Kraus I, Gössl M, Richt J, Garten W. Maturation of Borna disease virus glycoprotein. FEBS Lett. 2005;579:4751-6 pubmed
    The maturation of Borna disease virus (BDV) glycoprotein GP was studied in regard to intracellular compartmentalization, compartmentalization signal-domains, proteolytic processing, and packaging into virus particles...
  30. Köster Patzlaff C, Hosseini S, Reuss B. Layer specific changes of astroglial gap junctions in the rat cerebellar cortex by persistent Borna Disease Virus infection. Brain Res. 2008;1219:143-58 pubmed publisher
    Neonatal Borna Disease Virus (BDV) infection of the Lewis rat brain, leads to Purkinje cell degeneration, in association with astroglial activation...
  31. Briese T, Schneemann A, Lewis A, Park Y, Kim S, Ludwig H, et al. Genomic organization of Borna disease virus. Proc Natl Acad Sci U S A. 1994;91:4362-6 pubmed
    b>Borna disease virus is a neurotropic negative-strand RNA virus that infects a wide range of vertebrate hosts, causing disturbances in movement and behavior...
  32. Peng G, Yan Y, Zhu C, Wang S, Yan X, Lu L, et al. Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein. J Virol. 2008;82:12487-97 pubmed publisher
    b>Borna disease virus (BDV) is one of the infectious agents that causes diseases of the central nervous system in a wide range of vertebrate species and, perhaps, in humans...
  33. Nowotny N, Kolodziejek J, Jehle C, Suchy A, Staeheli P, Schwemmle M. Isolation and characterization of a new subtype of Borna disease virus. J Virol. 2000;74:5655-8 pubmed
    b>Borna disease virus (BDV), the causative agent of severe meningoencephalitis in a wide variety of animal species, has been considered to be genetically invariable and to form a single type within the genus Bornavirus of the family ..
  34. Furrer E, Planz O, Stitz L. Inhibition of Borna disease virus-mediated cell fusion by monoclonal antibodies directed against the viral glycoprotein. Intervirology. 2004;47:108-13 pubmed
    b>Borna disease virus-infected Vero cells express on their surface the major viral glycoprotein which mediates cell fusion after low pH treatment...
  35. Caplazi P, Ehrensperger F. Spontaneous Borna disease in sheep and horses: immunophenotyping of inflammatory cells and detection of MHC-I and MHC-II antigen expression in Borna encephalitis lesions. Vet Immunol Immunopathol. 1998;61:203-20 pubmed
    ..disorder of the central nervous system (CNS), as shown by experimental infection of rats with Borna disease virus (BDV)...
  36. Enbergs H, Vahlenkamp T, Kipar A, Muller H. Experimental infection of mice with Borna disease virus (BDV): replication and distribution of the virus after intracerebral infection. J Neurovirol. 2001;7:272-7 pubmed
    To develop an animal model resembling natural asymptomatic Borna disease virus (BDV) infections, BDV He/80 rat brain homogenate was passaged four times in adult SJL/J mice...
  37. Zocher M, Czub S, Schulte Mönting J, de La Torre J, Sauder C. Alterations in neurotrophin and neurotrophin receptor gene expression patterns in the rat central nervous system following perinatal Borna disease virus infection. J Neurovirol. 2000;6:462-77 pubmed
    Infection of newborn rats with Borna disease virus (BDV) leads to persistence in the absence of overt signs of inflammation...
  38. Walker M, Lipkin W. Characterization of the nuclear localization signal of the borna disease virus polymerase. J Virol. 2002;76:8460-7 pubmed
    b>Borna disease virus (BDV) is a nonsegmented negative-strand RNA virus that replicates and transcribes its genome in the nucleus of infected cells...
  39. Planz O, Pleschka S, Oesterle K, Berberich Siebelt F, Ehrhardt C, Stitz L, et al. Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex. J Virol. 2003;77:11186-92 pubmed
    ..Here, we report that persistent infection with Borna disease virus (BDV), a noncytolytic RNA virus infecting the central nervous system, results in decelerated proliferation ..
  40. Friedl G, Hofer M, Auber B, Sauder C, Hausmann J, Staeheli P, et al. Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12. J Virol. 2004;78:1212-8 pubmed
    b>Borna disease virus (BDV) induces a nonpurulent CD4- and CD8-T-cell-dependent meningoencephalitis in susceptible animals...
  41. Chalmers R, Thomas D, Salmon R. Borna disease virus and the evidence for human pathogenicity: a systematic review. QJM. 2005;98:255-74 pubmed
    Borna disease is a neurological viral disease of veterinary importance in central Europe, although Borna Disease virus (BDV) has been reported to be present in animals in most continents...
  42. Kinnunen P, Billich C, Ek Kommonen C, Henttonen H, Kallio R, Niemimaa J, et al. Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland. J Clin Virol. 2007;38:64-9 pubmed
    b>Borna disease virus (BDV) can infect many vertebrate species, including humans. BDV infection may lead to meningoencephalomyelitis in animals...
  43. Clemente R, de la Torre J. Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules. J Virol. 2009;83:10406-16 pubmed publisher
    b>Borna disease virus (BDV), the prototypic member of the Bornaviridae family within the order Mononegavirales, exhibits high neurotropism and provides an important and unique experimental model system for studying virus-cell interactions ..
  44. Watanabe Y, Ohtaki N, Hayashi Y, Ikuta K, Tomonaga K. Autogenous translational regulation of the Borna disease virus negative control factor X from polycistronic mRNA using host RNA helicases. PLoS Pathog. 2009;5:e1000654 pubmed publisher
    b>Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that employs several unique strategies for gene expression...
  45. Ackermann A, Guelzow T, Staeheli P, Schneider U, Heimrich B. Visualizing viral dissemination in the mouse nervous system, using a green fluorescent protein-expressing Borna disease virus vector. J Virol. 2010;84:5438-42 pubmed publisher
    b>Borna disease virus (BDV) frequently persists in the brain of infected animals. To analyze viral dissemination in the mouse nervous system, we generated a mouse-adapted virus that expresses green fluorescent protein (GFP)...
  46. Qian J, Zhai A, Kao W, Li Y, Song W, Fu Y, et al. Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells. Antiviral Res. 2010;87:249-56 pubmed publisher
    ..sequences between miR-122 and viral mRNAs, may be important for the antiviral effect of miR-122 on Borna disease virus (BDV)...
  47. Berg M, Johansson M, Montell H, Berg A. Wild birds as a possible natural reservoir of Borna disease virus. Epidemiol Infect. 2001;127:173-8 pubmed
    The natural reservoir of Borna disease virus (BDV) is unknown. In this paper, we show that mallards (Anas platyrhyncos) and jackdaws (Corvus monedula) can be subclinically infected carriers of this virus...
  48. Kraus I, Eickmann M, Kiermayer S, Scheffczik H, Fluess M, Richt J, et al. Open reading frame III of borna disease virus encodes a nonglycosylated matrix protein. J Virol. 2001;75:12098-104 pubmed
    The open reading frame III of Borna disease virus (BDV) codes for a protein with a mass of 16 kDa, named p16 or BDV-M...
  49. Johansson M, Berg M, Berg A. Humoral immune response against Borna disease virus (BDV) in experimentally and naturally infected cats. Vet Immunol Immunopathol. 2002;90:23-33 pubmed
    In order to investigate the peripheral and intracerebral humoral immune response against Borna disease virus (BDV) in cats, serum and cerebrospinal fluid (CSF) samples from experimentally and naturally BDV-infected cats were analysed in ..
  50. Kobayashi T, Zhang G, Lee B, Baba S, Yamashita M, Kamitani W, et al. Modulation of Borna disease virus phosphoprotein nuclear localization by the viral protein X encoded in the overlapping open reading frame. J Virol. 2003;77:8099-107 pubmed
    b>Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that belongs to the Mononegavirales order. Unlike other animal viruses in this order, BDV replicates and transcribes in the nucleus of infected cells...
  51. Pletnikov M, Rubin S, Moran T, Carbone K. Exploring the cerebellum with a new tool: neonatal Borna disease virus (BDV) infection of the rat's brain. Cerebellum. 2003;2:62-70 pubmed
    ..One of the most interesting in vivo models of virus-induced cerebellar damage is the neonatal Borna disease virus (BDV) infection of the rat brain...
  52. Rudolph M, Kraus I, Dickmanns A, Eickmann M, Garten W, Ficner R. Crystal structure of the borna disease virus nucleoprotein. Structure. 2003;11:1219-26 pubmed
    b>Borna disease virus (BDV) causes an infection of the central nervous system in a wide range of vertebrates, which can fatally progress to an immune-mediated disease, called Borna disease...
  53. Terayama H, Nishino Y, Kishi M, Ikuta K, Itoh M, Iwahashi K. Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan. Psychiatry Res. 2003;120:201-6 pubmed
    The relationship between infection with the Borna Disease Virus (BDV) and the clinical symptoms of schizophrenia and mood disorders (DMS-IV) was investigated...
  54. Schneider U, Schwemmle M, Staeheli P. Genome trimming: a unique strategy for replication control employed by Borna disease virus. Proc Natl Acad Sci U S A. 2005;102:3441-6 pubmed
    ..The ITR of Borna disease virus (BDV), a persisting neurotropic virus with a nuclear replication phase, are exceptional in that they appear ..
  55. Ovanesov M, Sauder C, Rubin S, Richt J, Nath A, Carbone K, et al. Activation of microglia by borna disease virus infection: in vitro study. J Virol. 2006;80:12141-8 pubmed
    Neonatal Borna disease virus (BDV) infection of the rat brain is associated with microglial activation and damage to the certain neuronal populations...
  56. Kramer K, Schaudien D, Eisel U, Herzog S, Richt J, Baumgartner W, et al. TNF-overexpression in Borna disease virus-infected mouse brains triggers inflammatory reaction and epileptic seizures. PLoS ONE. 2012;7:e41476 pubmed publisher
    Proinflammatory state of the brain increases the risk for seizure development. Neonatal Borna disease virus (BDV)-infection of mice with neuronal overexpression of tumor necrosis factor-? (TNF) was used to investigate the complex ..
  57. Planz O, Rentzsch C, Batra A, Winkler T, Buttner M, Rziha H, et al. Pathogenesis of borna disease virus: granulocyte fractions of psychiatric patients harbor infectious virus in the absence of antiviral antibodies. J Virol. 1999;73:6251-6 pubmed
    b>Borna disease virus (BDV) causes acute and persistent infections in various vertebrates...
  58. Chen C, Chiu Y, Shaw C, Tsai M, Hwang A, Hsiao K. Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers. Mol Psychiatry. 1999;4:566-71 pubmed
    Accumulating evidence suggests that Borna disease virus (BDV), a neurotropic, negative-stranded RNA virus, might be associated with certain human mental disorders...
  59. Vahlenkamp T, Enbergs H, Muller H. Experimental and natural borna disease virus infections: presence of viral RNA in cells of the peripheral blood. Vet Microbiol. 2000;76:229-44 pubmed
    Cells of the peripheral blood of experimentally and naturally borna disease virus (BDV)-infected animals and of human psychiatric patients and healthy individuals were analyzed for the presence of viral RNA using a BDV-p40-specific ..
  60. Staeheli P, Sentandreu M, Pagenstecher A, Hausmann J. Alpha/beta interferon promotes transcription and inhibits replication of borna disease virus in persistently infected cells. J Virol. 2001;75:8216-23 pubmed
    b>Borna disease virus (BDV) is a noncytolytic RNA virus that can replicate in the central nervous system (CNS) of mice...
  61. Horii Y, Garcia N, Noviana D, Kono F, Sawada T, Naraki T, et al. Detection of anti-borna disease virus antibodies from cats in Asian countries, Japan, Philippines and Indonesia using electrochemiluminescence immunoassay. J Vet Med Sci. 2001;63:921-3 pubmed
    Anti-Borna disease virus (BDV) antibodies were detected from cats in Japan, Philippines and Indonesia by using electrochemiluminescence immunoassay. Positive rates were 3.1%, 3.8% and 2...
  62. Yilmaz H, Helps C, Turan N, Uysal A, Harbour D. Detection of antibodies to Borna disease virus (BDV) in Turkish horse sera using recombinant p40. Brief report. Arch Virol. 2002;147:429-35 pubmed
    The nucleoprotein of Borna disease virus (BDV-p40) was produced in a Baculovirus expression system using sf9 cells. The purity and specificity of the recombinant p40 was confirmed by SDS-PAGE and immunoblotting...
  63. Henkel M, Planz O, Fischer T, Stitz L, Rziha H. Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant. J Virol. 2005;79:314-25 pubmed
    ..virus strain D1701 was used to generate a recombinant virus (D1701-VrVp40) expressing nucleoprotein p40 of Borna disease virus, which represents a major antigen for the induction of a Borna disease virus-specific humoral and cellular ..
  64. Gonzalez Dunia D, Volmer R, Mayer D, Schwemmle M. Borna disease virus interference with neuronal plasticity. Virus Res. 2005;111:224-34 pubmed
    ..The mechanisms whereby such infections disturb brain functions are beginning to emerge. Borna disease virus (BDV), which causes a persistent infection of neurons without direct cytolysis in several mammalian hosts, ..
  65. Schneider U. Novel insights into the regulation of the viral polymerase complex of neurotropic Borna disease virus. Virus Res. 2005;111:148-60 pubmed
    b>Borna disease virus (BDV) genetic information is encoded in a highly condensed non-segmented RNA genome of negative polarity...
  66. Yanai H, Kobayashi T, Hayashi Y, Watanabe Y, Ohtaki N, Zhang G, et al. A methionine-rich domain mediates CRM1-dependent nuclear export activity of Borna disease virus phosphoprotein. J Virol. 2006;80:1121-9 pubmed
    b>Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that replicates and transcribes in the nucleus of infected cells...
  67. Poenisch M, Wille S, Staeheli P, Schneider U. Polymerase read-through at the first transcription termination site contributes to regulation of borna disease virus gene expression. J Virol. 2008;82:9537-45 pubmed publisher
    An unusually long noncoding sequence is located between the N gene of Borna disease virus (BDV) and the genes for regulatory factor X and polymerase cofactor P...
  68. Hock M, Kraus I, Schoehn G, Jamin M, Andrei Selmer C, Garten W, et al. RNA induced polymerization of the Borna disease virus nucleoprotein. Virology. 2010;397:64-72 pubmed publisher
    The Borna disease virus (BDV) nucleoprotein (N) monomer resembles the nucleoprotein structures from rabies virus (RABV) and vesicular stomatitis virus (VSV)...
  69. Lipkin W, Travis G, Carbone K, Wilson M. Isolation and characterization of Borna disease agent cDNA clones. Proc Natl Acad Sci U S A. 1990;87:4184-8 pubmed
    ..Northern (RNA) hybridizations using these RNA probes indicated that the BD agent is probably a virus with major transcripts of 8.5, 2.1, and 0.8 kilobases...
  70. Gonzalez Dunia D, Watanabe M, Syan S, Mallory M, Masliah E, de La Torre J. Synaptic pathology in Borna disease virus persistent infection. J Virol. 2000;74:3441-8 pubmed
    b>Borna disease virus (BDV) infection of newborn rats leads to a persistent infection of the brain, which is associated with behavioral and neuroanatonomical abnormalities...
  71. Perez M, Sanchez A, Cubitt B, Rosario D, de la Torre J. A reverse genetics system for Borna disease virus. J Gen Virol. 2003;84:3099-104 pubmed
    b>Borna disease virus (BDV) is an enveloped virus. Its non-segmented, negative-stranded RNA genome has the coding capability for six main polypeptides and has an organization characteristic of members of the order Mononegavirales...
  72. Hans A, Bajramovic J, Syan S, Perret E, Dunia I, Brahic M, et al. Persistent, noncytolytic infection of neurons by Borna disease virus interferes with ERK 1/2 signaling and abrogates BDNF-induced synaptogenesis. FASEB J. 2004;18:863-5 pubmed
    Infection of the central nervous system by Borna disease virus (BDV) provides a unique model to study the mechanisms whereby a persistent viral infection can impair neuronal function and cause behavioral diseases reminiscent of mood ..
  73. Chase G, Mayer D, Hildebrand A, Frank R, Hayashi Y, Tomonaga K, et al. Borna disease virus matrix protein is an integral component of the viral ribonucleoprotein complex that does not interfere with polymerase activity. J Virol. 2007;81:743-9 pubmed
    We have recently shown that the matrix protein M of Borna disease virus (BDV) copurifies with the affinity-purified nucleoprotein (N) from BDV-infected cells, suggesting that M is an integral component of the viral ribonucleoprotein ..
  74. Peng G, Zhang F, Zhang Q, Wu K, Zhu F, Wu J. Borna disease virus P protein inhibits nitric oxide synthase gene expression in astrocytes. Virology. 2007;366:446-52 pubmed
    b>Borna disease virus (BDV) is one of the potential infectious agents involved in the development of central nervous system (CNS) diseases...
  75. Li Q, Wang Z, Zhu D, Xu M, Chen X, Peng D, et al. Detection and analysis of Borna disease virus in Chinese patients with neurological disorders. Eur J Neurol. 2009;16:399-403 pubmed publisher
    b>Borna disease virus (BDV) is a neurotropic RNA virus that is known to cause neurological disturbances in various animal species, potentially even humans...
  76. Horie M, Honda T, Suzuki Y, Kobayashi Y, Daito T, Oshida T, et al. Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature. 2010;463:84-7 pubmed publisher
    ..We also show that the N mRNA of a current mammalian bornavirus, Borna disease virus (BDV), can form EBLN-like elements in the genomes of persistently infected cultured cells...
  77. Martin A, Hoefs N, Tadewaldt J, Staeheli P, Schneider U. Genomic RNAs of Borna disease virus are elongated on internal template motifs after realignment of the 3' termini. Proc Natl Acad Sci U S A. 2011;108:7206-11 pubmed publisher
    The terminal structures of the Borna disease virus (BDV) genome (vRNA) and antigenome (cRNA) differ from those of other negative strand RNA viruses, as both molecules possess four nucleotides at the 3' terminus without an apparent ..
  78. Dietz D, Pletnikov M. Postnatal weight gain inhibition does not account for neurobehavioral consequences of neonatal Borna disease virus infection. Physiol Behav. 2003;80:359-66 pubmed
    Neonatal Borna disease virus (BDV) infection of the rat's brain produces neurodevelopmental damage similar to some pathological and clinical features of human developmental disorders, e.g., autism and schizophrenia...
  79. Herden C, Schluesener H, Richt J. Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus. Neuropathol Appl Neurobiol. 2005;31:512-21 pubmed
    Experimental infection of Lewis rats with Borna disease virus (BDV) causes an immune-mediated nonpurulent meningoencephalitis...
  80. Wensman J, Thoren P, Hakhverdyan M, Belak S, Berg M. Development of a real-time RT-PCR assay for improved detection of Borna disease virus. J Virol Methods. 2007;143:1-10 pubmed
    b>Borna disease virus (BDV) is a non-segmented, negative-stranded RNA virus, which infects cells of the central nervous system (CNS) in many different species...
  81. Pfannkuche H, Konrath A, Buchholz I, Richt J, Seeger J, Muller H, et al. Infection of the enteric nervous system by Borna disease virus (BDV) upregulates expression of Calbindin D-28k. Vet Microbiol. 2008;127:275-85 pubmed
    b>Borna disease virus (BDV) is a neurotropic agent infecting distinct neuronal subpopulations in the central nervous system of various mammalian species possibly including humans...
  82. Brnic D, Stevanovic V, Cochet M, Agier C, Richardson J, Montero Menei C, et al. Borna disease virus infects human neural progenitor cells and impairs neurogenesis. J Virol. 2012;86:2512-22 pubmed publisher
    ..The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms...
  83. Matsumoto Y, Hayashi Y, Omori H, Honda T, Daito T, Horie M, et al. Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection. Cell Host Microbe. 2012;11:492-503 pubmed publisher
    ..However, how these viruses achieve intranuclear infection remains unclear. We show that Borna disease virus (BDV), a mammalian bornavirus, closely associates with the cellular chromosome to ensure intranuclear ..
  84. Jordan I, Lipkin W. Borna disease virus. Rev Med Virol. 2001;11:37-57 pubmed
    b>Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolytic CNS-infection in a wide variety of host species...
  85. Helps C, Turan N, Bilal T, Harbour D, Yilmaz H. Detection of antibodies to Borna disease virus in Turkish cats by using recombinant p40. Vet Rec. 2001;149:647-50 pubmed
    ..Antibodies to Borna disease virus- (BDV) p40 were detected in 34 (42-5 per cent) of the 80 cats...
  86. Pletnikov M, Moran T, Carbone K. Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders. Front Biosci. 2002;7:d593-607 pubmed
    ..The present review provides a detailed analysis of a new animal model of ASD. This model utilizes neonatal Borna disease virus (BDV) infection of the rat brain as a unique experimental teratogen to study the pathogenesis of ..
  87. Vahlenkamp T, Konrath A, Weber M, Muller H. Persistence of Borna disease virus in naturally infected sheep. J Virol. 2002;76:9735-43 pubmed
    To get an insight into Borna disease virus (BDV) epidemiology, an isolated flock of approximately 25 sheep within the region of Southeast Germany to which the disease is endemic was investigated over a 3-year observation period...
  88. de la Torre J. Bornavirus and the brain. J Infect Dis. 2002;186 Suppl 2:S241-7 pubmed
    b>Borna disease virus (BDV) causes central nervous system (CNS) disease that is frequently manifested by behavioral abnormalities. BDV is a nonsegmented, negative, single-stranded RNA virus...
  89. Schneider U, Naegele M, Staeheli P. Regulation of the Borna disease virus polymerase complex by the viral nucleoprotein p38 isoform. Brief Report. Arch Virol. 2004;149:1409-14 pubmed
    b>Borna disease virus (BDV) polymerase can be reconstituted by co-expression of the viral genes N, P and L. N codes for two proteins, p39 and p38, resulting from alternative translation initiation...
  90. Ovanesov M, Vogel M, Moran T, Pletnikov M. Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum. J Neurovirol. 2007;13:185-94 pubmed
    The authors evaluated a role of glutamate (GLU) excitotoxicity in neonatal Borna disease virus (BDV) infection-associated neuronal injury by measuring extracellular levels of GLU in the striatum of 70-day-old Fischer344 rats using in ..
  91. Poenisch M, Staeheli P, Schneider U. Viral accessory protein X stimulates the assembly of functional Borna disease virus polymerase complexes. J Gen Virol. 2008;89:1442-5 pubmed publisher
    The Borna disease virus (BDV) proteins X and P are translated from a bicistronic viral mRNA...
  92. Neumann P, Lieber D, Meyer S, Dautel P, Kerth A, Kraus I, et al. Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals ssRNA binding properties. Proc Natl Acad Sci U S A. 2009;106:3710-5 pubmed publisher
    b>Borna disease virus (BDV) is a neurotropic enveloped RNA virus that causes a noncytolytic, persistent infection of the central nervous system in mammals...