zika virus


Summary: An arbovirus in the FLAVIVIRUS genus of the family FLAVIVIRIDAE. Originally isolated in the Zika Forest of UGANDA it has been introduced to Asia and the Americas.

Top Publications

  1. Olson J, Ksiazek T, Suhandiman -, Triwibowo -. Zika virus, a cause of fever in Central Java, Indonesia. Trans R Soc Trop Med Hyg. 1981;75:389-93 pubmed
    ..The onsets of illness clustered toward the end of the rainy season when populations of Aedes aegypti, a probable vector in Malaysia, were most abundant. ..
  2. Marchette N, Garcia R, Rudnick A. Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg. 1969;18:411-5 pubmed
  3. Moura Da Silva A, Ganz J, Sousa P, Doriqui M, Ribeiro M, Branco M, et al. Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome. Emerg Infect Dis. 2016;22:1953-1956 pubmed publisher
    We report the early growth and neurologic findings of 48 infants in Brazil diagnosed with probable congenital Zika virus syndrome and followed to age 1-8 months. Most of these infants had microcephaly (86...
  4. Musso D, Nilles E, Cao Lormeau V. Rapid spread of emerging Zika virus in the Pacific area. Clin Microbiol Infect. 2014;20:O595-6 pubmed publisher
  5. Lipsitch M, Cowling B. Zika vaccine trials. Science. 2016;353:1094-5 pubmed publisher
  6. Dyer O. Zika virus spreads across Americas as concerns mount over birth defects. BMJ. 2015;351:h6983 pubmed publisher
  7. Reveiz L, Haby M, Martínez Vega R, Pinzón Flores C, Elias V, Smith E, et al. Risk of bias and confounding of observational studies of Zika virus infection: A scoping review of research protocols. PLoS ONE. 2017;12:e0180220 pubmed publisher
    Given the severity and impact of the current Zika virus (ZIKV) outbreak in the Americas, numerous countries have rushed to develop research studies to assess ZIKV and its potential health consequences...
  8. Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao Lormeau V. Potential sexual transmission of Zika virus. Emerg Infect Dis. 2015;21:359-61 pubmed publisher
    In December 2013, during a Zika virus (ZIKV) outbreak in French Polynesia, a patient in Tahiti sought treatment for hematospermia, and ZIKV was isolated from his semen. ZIKV transmission by sexual intercourse has been previously suspected...
  9. Liu Y, Liu J, Du S, Shan C, Nie K, Zhang R, et al. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes. Nature. 2017;545:482-486 pubmed publisher
    b>Zika virus (ZIKV) remained obscure until the recent explosive outbreaks in French Polynesia (2013-2014) and South America (2015-2016). Phylogenetic studies have shown that ZIKV has evolved into African and Asian lineages...

More Information


  1. Oh Y, Zhang F, Wang Y, Lee E, Choi I, Lim H, et al. Zika virus directly infects peripheral neurons and induces cell death. Nat Neurosci. 2017;20:1209-1212 pubmed publisher
    b>Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection...
  2. Li Y, Phoo W, Loh Y, Zhang Z, Ng E, Wang W, et al. Structural characterization of the linked NS2B-NS3 protease of Zika virus. FEBS Lett. 2017;591:2338-2347 pubmed publisher
    The Zika virus (ZIKV) NS2B-NS3 protease is an important drug target...
  3. Li J, Xiong Y, Wu W, Liu X, Qu J, Zhao X, et al. Zika Virus in a Traveler Returning to China from Caracas, Venezuela, February 2016. Emerg Infect Dis. 2016;22:1133-6 pubmed publisher
  4. Haug C, Kieny M, Murgue B. The Zika Challenge. N Engl J Med. 2016;374:1801-3 pubmed publisher
  5. Yepez J, Murati F, Pettito M, Peñaranda C, De Yepez J, Maestre G, et al. Ophthalmic Manifestations of Congenital Zika Syndrome in Colombia and Venezuela. JAMA Ophthalmol. 2017;135:440-445 pubmed publisher
    The ocular manifestations and sequelae of Zika virus infection are not well known...
  6. Mattar S, Ojeda C, Arboleda J, Arrieta G, Bosch I, Botia I, et al. Case report: microcephaly associated with Zika virus infection, Colombia. BMC Infect Dis. 2017;17:423 pubmed publisher
    Recently there has been a large outbreak of Zika virus infections in Colombia, South America. The epidemic began in September 2015 and continued to April 2017, for the total number of Zika cases reported of 107,870...
  7. Dasgupta S, Reagan Steiner S, Goodenough D, Russell K, Tanner M, Lewis L, et al. Patterns in Zika Virus Testing and Infection, by Report of Symptoms and Pregnancy Status - United States, January 3-March 5, 2016. MMWR Morb Mortal Wkly Rep. 2016;65:395-9 pubmed publisher
    CDC recommends Zika virus testing for potentially exposed persons with signs or symptoms consistent with Zika virus disease, and recommends that health care providers offer testing to asymptomatic pregnant women within 12 weeks of ..
  8. Shirley D, Nataro J. Zika Virus Infection. Pediatr Clin North Am. 2017;64:937-951 pubmed publisher
    In less than 2 years since entry into the Americas, we have witnessed the emergent spread of Zika virus into large subsets of immunologically naïve human populations and then encountered the devastating effects of microcephaly and brain ..
  9. Garg H, Sedano M, Plata G, Punke E, Joshi A. Development of Virus-Like-Particle Vaccine and Reporter Assay for Zika Virus. J Virol. 2017;91: pubmed publisher
    Recent worldwide outbreaks of Zika virus (ZIKV) infection and the lack of an approved vaccine raise serious concerns regarding preparedness to combat this emerging virus...
  10. McDonald E, Duggal N, Brault A. Pathogenesis and sexual transmission of Spondweni and Zika viruses. PLoS Negl Trop Dis. 2017;11:e0005990 pubmed publisher
    The Spondweni serogroup of viruses (Flaviviridae, Flavivirus) is comprised of Spondweni virus (SPONV) and Zika virus (ZIKV), which are mosquito-borne viruses capable of eliciting human disease...
  11. Bell T, Field E, Narang H. Zika virus infection of the central nervous system of mice. Arch Gesamte Virusforsch. 1971;35:183-93 pubmed
  12. Cao B, Parnell L, Diamond M, Mysorekar I. Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice. J Exp Med. 2017;214:2303-2313 pubmed publisher
    b>Zika virus (ZIKV) infection during pregnancy leads to devastating fetal outcomes, including intrauterine growth restriction and microcephaly...
  13. Roundy C, Azar S, Brault A, Ebel G, Failloux A, Fernandez Salas I, et al. Lack of evidence for Zika virus transmission by Culex mosquitoes. Emerg Microbes Infect. 2017;6:e90 pubmed publisher
  14. Olynk Widmar N, Dominick S, Tyner W, Ruple A. When is genetic modification socially acceptable? When used to advance human health through avenues other than food. PLoS ONE. 2017;12:e0178227 pubmed publisher
    ..e. disease vector control) and provides an in-depth analysis of a timely case study-the Zika virus (ZIKV)...
  15. Sebrango Rodríguez C, Martínez Bello D, Sánchez Valdés L, Thilakarathne P, Del Fava E, Van der Stuyft P, et al. Real-time parameter estimation of Zika outbreaks using model averaging. Epidemiol Infect. 2017;145:2313-2323 pubmed publisher
    ..The proposed method is applied to Zika outbreak data in four cities from Colombia, during the outbreak ocurred in 2015-2016...
  16. Grubaugh N, Ladner J, Kraemer M, Dudas G, Tan A, Gangavarapu K, et al. Genomic epidemiology reveals multiple introductions of Zika virus into the United States. Nature. 2017;546:401-405 pubmed publisher
    b>Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities...
  17. Kam Y, Leite J, Lum F, Tan J, Lee B, Judice C, et al. Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil. J Infect Dis. 2017;216:172-181 pubmed publisher
    b>Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations...
  18. Petribu N, Aragão M, van der Linden V, Parizel P, Jungmann P, Araújo L, et al. Follow-up brain imaging of 37 children with congenital Zika syndrome: case series study. BMJ. 2017;359:j4188 pubmed publisher
    ..b>Conclusion The detection of cerebral calcifications should not be considered a major criterion for late diagnosis of congenital Zika syndrome, nor should the absence of calcifications be used to exclude the diagnosis. ..
  19. Nicastri E, Castilletti C, Balestra P, Galgani S, Ippolito G. Zika Virus Infection in the Central Nervous System and Female Genital Tract. Emerg Infect Dis. 2016;22:2228-2230 pubmed publisher
  20. Walker W, Lindsey N, Lehman J, Krow Lucal E, Rabe I, Hills S, et al. Zika Virus Disease Cases - 50 States and the District of Columbia, January 1-July 31, 2016. MMWR Morb Mortal Wkly Rep. 2016;65:983-6 pubmed publisher
    b>Zika virus is a mosquito-borne flavivirus primarily transmitted to humans by Aedes aegypti mosquitoes (1)...
  21. Cardoso C, Paploski I, Kikuti M, Rodrigues M, Silva M, Campos G, et al. Outbreak of Exanthematous Illness Associated with Zika, Chikungunya, and Dengue Viruses, Salvador, Brazil. Emerg Infect Dis. 2015;21:2274-6 pubmed publisher
  22. Bogoch I, Brady O, Kraemer M, German M, Creatore M, Kulkarni M, et al. Anticipating the international spread of Zika virus from Brazil. Lancet. 2016;387:335-336 pubmed publisher
  23. Cauchemez S, Besnard M, Garel C, Fontanet A, Mallet H. Could clinical symptoms be a predictor of complications in Zika virus infection? - Authors' reply. Lancet. 2016;388:338-339 pubmed publisher
  24. Yudhaputri F, Trimarsanto H, Perkasa A, Yohan B, Haryanto S, Wiyatno A, et al. Genomic characterization of Zika virus isolated from Indonesia. Virology. 2017;510:248-251 pubmed publisher
    b>Zika virus (ZIKV) JMB-185 strain was isolated from a febrile patient in Jambi, Indonesia in 2014...
  25. Cohen J. INFECTIOUS DISEASE. The race for a Zika vaccine is on. Science. 2016;351:543-4 pubmed publisher
  26. Paniz Mondolfi A, Rodriguez Morales A, Blohm G, Marquez M, Villamil Gomez W. ChikDenMaZika Syndrome: the challenge of diagnosing arboviral infections in the midst of concurrent epidemics. Ann Clin Microbiol Antimicrob. 2016;15:42 pubmed publisher
  27. Lee A, Bhattacharya R, Scheuermann R, Pickett B. Identification of diagnostic peptide regions that distinguish Zika virus from related mosquito-borne Flaviviruses. PLoS ONE. 2017;12:e0178199 pubmed publisher
    b>Zika virus (ZIKV) is a member of the Flavivirus genus of positive-sense single-stranded RNA viruses, which includes Dengue, West Nile, Yellow Fever, and other mosquito-borne arboviruses...
  28. McConnell J, De Ambrogi M, Cleghorn S, Sekkides O. Zika virus and the 2016 Olympic Games - Editors' reply. Lancet Infect Dis. 2016;16:1003-1004 pubmed publisher
  29. O Donnell K, Bixby M, Morin K, Bradley D, Vaughan J. Potential of a Northern Population of Aedes vexans (Diptera: Culicidae) to Transmit Zika Virus. J Med Entomol. 2017;54:1354-1359 pubmed publisher
    b>Zika virus is an emerging arbovirus of humans in the western hemisphere. With its potential spread into new geographical areas, it is important to define the vector competence of native mosquito species...
  30. Schultz M, Isern S, Michael S, Corley R, Connor J, Frydman H. Variable Inhibition of Zika Virus Replication by Different Wolbachia Strains in Mosquito Cell Cultures. J Virol. 2017;91: pubmed publisher
    ..Consequently, it is important to investigate additional Wolbachia strains. All Zika virus (ZIKV) suppression studies are limited to the wMel Wolbachia strain...
  31. Smartt C, Stenn T, Chen T, Teixeira M, Queiroz E, Souza Dos Santos L, et al. Evidence of Zika Virus RNA Fragments in Aedes albopictus (Diptera: Culicidae) Field-Collected Eggs From Camaçari, Bahia, Brazil. J Med Entomol. 2017;54:1085-1087 pubmed publisher
    A major mosquito-borne viral disease outbreak caused by Zika virus (ZIKV) occurred in Bahia, Brazil, in 2015, largely due to transmission by the mosquito, Aedes aegypti (L.). Detecting ZIKV in field samples of Ae...
  32. Enfissi A, Codrington J, Roosblad J, Kazanji M, Rousset D. Zika virus genome from the Americas. Lancet. 2016;387:227-8 pubmed publisher
  33. Varjak M, Donald C, Mottram T, Sreenu V, Merits A, Maringer K, et al. Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Negl Trop Dis. 2017;11:e0006010 pubmed publisher
    ..In Aedes aegypti-derived cells, Zika virus (ZIKV)-specific siRNAs were produced and loaded into the exo-siRNA pathway effector protein Argonaute 2 (Ago2); ..
  34. Mansuy J, Mengelle C, Pasquier C, Chapuy Regaud S, Delobel P, Martin Blondel G, et al. Zika Virus Infection and Prolonged Viremia in Whole-Blood Specimens. Emerg Infect Dis. 2017;23:863-865 pubmed publisher
    We tested whole-blood and plasma samples from immunocompetent patients who had had benign Zika virus infections and found that Zika virus RNA persisted in whole blood substantially longer than in plasma...
  35. Salinas S, Constant O, Desmetz C, Barthelemy J, Lemaitre J, Milhavet O, et al. Deleterious effect of Usutu virus on human neural cells. PLoS Negl Trop Dis. 2017;11:e0005913 pubmed publisher
    ..In the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged...
  36. Ishwarya R, Vaseeharan B, Anuradha R, Rekha R, Govindarajan M, Alharbi N, et al. Eco-friendly fabrication of Ag nanostructures using the seed extract of Pedalium murex, an ancient Indian medicinal plant: Histopathological effects on the Zika virus vector Aedes aegypti and inhibition of biofilm-forming pathogenic bacteria. J Photochem Photobiol B. 2017;174:133-143 pubmed publisher
    The control of Zika virus mosquito vectors and well as the development of drugs in the fight against biofilm-forming microbial pathogens, are timely and important challenges in current bionanoscience...
  37. Campos R, Cirne Santos C, Meira G, Santos L, de Meneses M, Friedrich J, et al. Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil. J Clin Virol. 2016;77:69-70 pubmed publisher
  38. Rodriguez Morales A. Zika: the new arbovirus threat for Latin America. J Infect Dev Ctries. 2015;9:684-5 pubmed publisher
  39. Arzuza Ortega L, Polo A, Pérez Tatis G, López García H, Parra E, Pardo Herrera L, et al. Fatal Sickle Cell Disease and Zika Virus Infection in Girl from Colombia. Emerg Infect Dis. 2016;22:925-7 pubmed publisher
  40. Willis E, Hensley S. Characterization of Zika virus binding and enhancement potential of a large panel of flavivirus murine monoclonal antibodies. Virology. 2017;508:1-6 pubmed publisher
    ..These data suggest that the ability of flavivirus Abs to enhance ZIKV is dependent on multiple factors. ..
  41. Speer S, Pierson T. VIROLOGY. Diagnostics for Zika virus on the horizon. Science. 2016;353:750-1 pubmed publisher
  42. Jeong Y, Cha G, Cho J, Lee E, Jee Y, Lee W. Viral and serological kinetics in Zika virus-infected patients in South Korea. Virol J. 2017;14:70 pubmed publisher
    b>Zika virus is a mosquito-borne flavivirus that causes clinical symptoms similar to those observed in dengue and chikungunya virus infections...
  43. Rodrigues L. Microcephaly and Zika virus infection. Lancet. 2016;387:2070-2072 pubmed publisher
  44. Meltzer E, Lustig Y, Leshem E, Levy R, Gottesman G, Weissmann R, et al. Zika Virus Disease in Traveler Returning from Vietnam to Israel. Emerg Infect Dis. 2016;22:1521-2 pubmed publisher
  45. Moni M, Lio P. Genetic Profiling and Comorbidities of Zika Infection. J Infect Dis. 2017;216:703-712 pubmed publisher
    The difficulty in distinguishing infection by Zika virus (ZIKV) from other flaviviruses is a global health concern, particularly given the high risk of neurologic complications (including Guillain-Barré syndrome [GBS]) with ZIKV infection...
  46. Reynolds M, Jones A, Petersen E, Lee E, Rice M, Bingham A, et al. Vital Signs: Update on Zika Virus-Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure - U.S. Zika Pregnancy Registry, 2016. MMWR Morb Mortal Wkly Rep. 2017;66:366-373 pubmed publisher
    ..Pregnancy Registry (USZPR) in early 2016 to monitor pregnant women with laboratory evidence of possible recent Zika virus infection and their infants...
  47. Richner J, Himansu S, Dowd K, Butler S, Salazar V, Fox J, et al. Modified mRNA Vaccines Protect against Zika Virus Infection. Cell. 2017;168:1114-1125.e10 pubmed publisher
    ..A modified mRNA vaccine can prevent ZIKV disease and be adapted to reduce the risk of sensitizing individuals to subsequent exposure to DENV, should this become a clinically relevant concern. ..
  48. Plourde A, Bloch E. A Literature Review of Zika Virus. Emerg Infect Dis. 2016;22:1185-92 pubmed publisher
    b>Zika virus is a mosquitoborne flavivirus that is the focus of an ongoing pandemic and public health emergency...
  49. Zhang Y, Chen W, Wong G, Bi Y, Yan J, Sun Y, et al. Highly diversified Zika viruses imported to China, 2016. Protein Cell. 2016;7:461-4 pubmed publisher
  50. Huang Y, Lyons A, Hsu W, Park S, Higgs S, Vanlandingham D. Differential outcomes of Zika virus infection in Aedes aegypti orally challenged with infectious blood meals and infectious protein meals. PLoS ONE. 2017;12:e0182386 pubmed publisher
    ..In this study, the infection process of Zika virus (ZIKV) in Aedes aegypti was characterized by oral exposure via viral suspension meals within minimally bovine ..
  51. Kiely P, Wood E, Gambhir M, Cheng A, McQuilten Z, Seed C. Emerging infectious disease agents and blood safety in Australia: spotlight on Zika virus. Med J Aust. 2017;206:455-460 pubmed
    ..The 2015-16 Zika virus (ZIKV) outbreak in the Americas is the largest reported ZIKV outbreak to date, and it highlights the ..
  52. Tian H, Ji X, Yang X, Xie W, Yang K, Chen C, et al. The crystal structure of Zika virus helicase: basis for antiviral drug design. Protein Cell. 2016;7:450-4 pubmed publisher
  53. Bukrejewska M, Derewenda U, Radwanska M, Engel D, Derewenda Z. Crystal structures of the methyltransferase and helicase from the ZIKA 1947 MR766 Uganda strain. Acta Crystallogr D Struct Biol. 2017;73:767-774 pubmed publisher
    Two nonstructural proteins encoded by Zika virus strain MR766 RNA, a methyltransferase and a helicase, were crystallized and their structures were solved and refined at 2.10 and 2.01?Å resolution, respectively...