dengue virus

Summary

Summary: A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.

Top Publications

  1. Cao Lormeau V, Roche C, Aubry M, Teissier A, Lastere S, Daudens E, et al. Recent emergence of dengue virus serotype 4 in French Polynesia results from multiple introductions from other South Pacific Islands. PLoS ONE. 2011;6:e29555 pubmed publisher
    Infection by dengue virus (DENV) is a major public health concern in hundreds of tropical and subtropical countries...
  2. Coulerie P, Nour M, Maciuk A, Eydoux C, Guillemot J, Lebouvier N, et al. Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp. Planta Med. 2013;79:1313-8 pubmed publisher
    b>Dengue virus is the world's most prevalent human pathogenic arbovirus. There is currently no treatment or vaccine, and solutions are urgently needed...
  3. Vervaeke P, Alen M, Noppen S, Schols D, Oreste P, Liekens S. Sulfated Escherichia coli K5 polysaccharide derivatives inhibit dengue virus infection of human microvascular endothelial cells by interacting with the viral envelope protein E domain III. PLoS ONE. 2013;8:e74035 pubmed publisher
    b>Dengue virus (DENV) is an emerging mosquito-borne pathogen that causes cytokine-mediated alterations in the barrier function of the microvascular endothelium, leading to dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
  4. Conway M, Watson A, Colpitts T, Dragovic S, Li Z, Wang P, et al. Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host. J Virol. 2014;88:164-75 pubmed publisher
    b>Dengue virus (DENV), a flavivirus of global importance, is transmitted to humans by mosquitoes. In this study, we developed in vitro and in vivo models of saliva-mediated enhancement of DENV infectivity...
  5. Smith S, de Alwis A, Kose N, Harris E, Ibarra K, Kahle K, et al. The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein. MBio. 2013;4:e00873-13 pubmed publisher
    Following natural dengue virus (DENV) infection, humans produce some antibodies that recognize only the serotype of infection (type specific) and others that cross-react with all four serotypes (cross-reactive)...
  6. Rabaa M, Simmons C, Fox A, Le M, Nguyen T, Le H, et al. Dengue virus in sub-tropical northern and central Viet Nam: population immunity and climate shape patterns of viral invasion and maintenance. PLoS Negl Trop Dis. 2013;7:e2581 pubmed publisher
    b>Dengue virus transmission occurs in both epidemic and endemic cycles across tropical and sub-tropical regions of the world...
  7. Hussain M, Asgari S. MicroRNA-like viral small RNA from Dengue virus 2 autoregulates its replication in mosquito cells. Proc Natl Acad Sci U S A. 2014;111:2746-51 pubmed publisher
    ..In search of functional miRNAs or viral small RNAs (vsRNAs) encoded by Dengue virus (DENV), deep sequencing data of virus-infected Aedes aegypti mosquitoes were used...
  8. Rancès E, Johnson T, Popovici J, Iturbe Ormaetxe I, Zakir T, Warr C, et al. The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference. J Virol. 2013;87:11945-9 pubmed publisher
    Wolbachia blocks dengue virus replication in Drosophila melanogaster as well as in Aedes aegypti...
  9. Choy M, Ellis B, Ellis E, Gubler D. Comparison of the mosquito inoculation technique and quantitative real time polymerase chain reaction to measure dengue virus concentration. Am J Trop Med Hyg. 2013;89:1001-5 pubmed publisher
    An accurate measure of infectious dengue virus in human and mosquito tissues is critical to fully understand virus-host relationships, disease severity, viral fitness, and pathogenesis...

More Information

Publications171 found, 100 shown here

  1. Chu P, Ke G, Chen P, Liu L, Tsai Y, Tsai J. Spatiotemporal dynamics and epistatic interaction sites in dengue virus type 1: a comprehensive sequence-based analysis. PLoS ONE. 2013;8:e74165 pubmed publisher
    ..Phylogenetic and recombination events were reconstructed based on 100 worldwide dengue virus (DENV) type 1 genome sequences with an outgroup (prototypes of DENV2-4)...
  2. Chen Y, Abdul Ghafar N, Karuna R, Fu Y, Lim S, Schul W, et al. Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir. J Virol. 2014;88:1740-7 pubmed publisher
    ..mononuclear cells (PBMCs; one of the major cells targeted for viral replication) that were preinfected with dengue virus. The elevated EC(50) was greater than the plasma trough concentration of R1479 observed in dengue patients ..
  3. Santiago G, Vergne E, Quiles Y, Cosme J, Vazquez J, Medina J, et al. Analytical and clinical performance of the CDC real time RT-PCR assay for detection and typing of dengue virus. PLoS Negl Trop Dis. 2013;7:e2311 pubmed publisher
    Dengue is an acute illness caused by the positive-strand RNA dengue virus (DENV). There are four genetically distinct DENVs (DENV-1-4) that cause disease in tropical and subtropical countries...
  4. Henriques H, Rampazo E, Gonçalves A, Vicentin E, Amorim J, Panatieri R, et al. Targeting the non-structural protein 1 from dengue virus to a dendritic cell population confers protective immunity to lethal virus challenge. PLoS Negl Trop Dis. 2013;7:e2330 pubmed publisher
    ..We conclude that targeting the NS1 protein to the DEC205(+) DC population with poly (I:C) opens perspectives for dengue vaccine development. ..
  5. Lozano Fuentes S, Wedyan F, Hernandez Garcia E, Sadhu D, Ghosh S, Bieman J, et al. Cell phone-based system (Chaak) for surveillance of immatures of dengue virus mosquito vectors. J Med Entomol. 2013;50:879-89 pubmed
    ..The cost-effectiveness of using the Chaak system will depend largely on the up-front cost of purchasing cell phones and the recurring cost of data transfer over a cellular network. ..
  6. Tsai W, Lai C, Wu Y, Lin H, Edwards C, Jumnainsong A, et al. High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection. J Virol. 2013;87:12562-75 pubmed publisher
    The envelope (E) protein of dengue virus (DENV) is the major target of neutralizing antibodies (Abs) and vaccine development...
  7. Garcia Cordero J, Carrillo Halfon S, León Juárez M, Romero Ramirez H, Valenzuela León P, Lopez Gonzalez M, et al. Generation and characterization of a rat monoclonal antibody against the RNA polymerase protein from Dengue Virus-2. Immunol Invest. 2014;43:28-40 pubmed publisher
    b>Dengue virus (DENV) RNA replication requires 2 viral proteins, non-structural protein 3 (NS3) and NS5...
  8. McCracken M, Christofferson R, Chisenhall D, Mores C. Analysis of early dengue virus infection in mice as modulated by Aedes aegypti probing. J Virol. 2014;88:1881-9 pubmed publisher
    b>Dengue virus (DENV), the etiologic agent of dengue fever, is transmitted during probing of human skin by infected-mosquito bite...
  9. Reich N, Shrestha S, King A, Rohani P, Lessler J, Kalayanarooj S, et al. Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity. J R Soc Interface. 2013;10:20130414 pubmed publisher
    ..These findings will impact strategies for designing dengue vaccine studies, future multi-strain modelling efforts, and our understanding of evolutionary pressures in multi-strain disease systems. ..
  10. Li Y, Kakinami C, Li Q, Yang B, Li H. Human apolipoprotein A-I is associated with dengue virus and enhances virus infection through SR-BI. PLoS ONE. 2013;8:e70390 pubmed publisher
    Diseases caused by dengue virus (DV) infection vary in severity, with symptoms ranging from mild fever to life threatening dengue hemorrhage fever (DHF) and dengue shock syndrome (DSS)...
  11. Montoya M, Gresh L, Mercado J, Williams K, Vargas M, Gutierrez G, et al. Symptomatic versus inapparent outcome in repeat dengue virus infections is influenced by the time interval between infections and study year. PLoS Negl Trop Dis. 2013;7:e2357 pubmed publisher
    Four dengue virus serotypes (DENV1-4) circulate globally, causing more human illness than any other arthropod-borne virus...
  12. Angleró Rodríguez Y, Pantoja P, Sariol C. Dengue virus subverts the interferon induction pathway via NS2B/3 protease-IκB kinase epsilon interaction. Clin Vaccine Immunol. 2014;21:29-38 pubmed publisher
    ..Here, we show that dengue virus (DENV) circumvents the induction of the retinoic acid-inducible gene I-like receptor (RLR) pathway during ..
  13. Chu L, Huang Y, Lee J, Huang L, Chen W, Lin Y, et al. Single-virus tracking approach to reveal the interaction of Dengue virus with autophagy during the early stage of infection. J Biomed Opt. 2014;19:011018 pubmed publisher
    b>Dengue virus (DENV) is one of the major infectious pathogens worldwide. DENV infection is a highly dynamic process...
  14. Liu Y, Liu H, Zou J, Zhang B, Yuan Z. Dengue virus subgenomic RNA induces apoptosis through the Bcl-2-mediated PI3k/Akt signaling pathway. Virology. 2014;448:15-25 pubmed publisher
    ..In addition, we found that subgenomic RNA modulates the phosphatidylinositol 3-kinase (PI3k)/Akt signaling pathway through a Bcl-2-related mechanism, resulting in apoptotic cell death...
  15. Morchang A, Panaampon J, Suttitheptumrong A, Yasamut U, Noisakran S, Yenchitsomanus P, et al. Role of cathepsin B in dengue virus-mediated apoptosis. Biochem Biophys Res Commun. 2013;438:20-5 pubmed publisher
    b>Dengue virus (DENV) infection is one of the most important mosquito-borne viral diseases, which is endemic in the tropical and sub-tropical regions...
  16. Fahri S, Yohan B, Trimarsanto H, Sayono S, Hadisaputro S, Dharmana E, et al. Molecular surveillance of dengue in Semarang, Indonesia revealed the circulation of an old genotype of dengue virus serotype-1. PLoS Negl Trop Dis. 2013;7:e2354 pubmed publisher
    ..Serotyping was performed in 31 patients, and we observed the co-circulation of all four dengue virus (DENV) serotypes...
  17. Dubot Pérès A, Vongphrachanh P, Denny J, Phetsouvanh R, Linthavong S, Sengkeopraseuth B, et al. An epidemic of dengue-1 in a remote village in rural Laos. PLoS Negl Trop Dis. 2013;7:e2360 pubmed publisher
    ..More epidemiological and entomological investigations are required to understand dengue epidemiology and the importance of rural and forest dengue dynamics in Laos. ..
  18. Ayala Nuñez N, Jarupathirun P, Kaptein S, Neyts J, Smit J. Antibody-dependent enhancement of dengue virus infection is inhibited by SA-17, a doxorubicin derivative. Antiviral Res. 2013;100:238-45 pubmed publisher
    Antibody-dependent enhancement (ADE) is thought to play a critical role in the exacerbation of dengue virus (DENV)-induced disease during a heterologous re-infection...
  19. Lim S, Koh J, Seh C, Liew C, Davidson A, Chua L, et al. A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities. J Biol Chem. 2013;288:31105-14 pubmed publisher
    The dengue virus (DENV) non-structural protein 5 (NS5) comprises an N-terminal methyltransferase and a C-terminal RNA-dependent RNA polymerase (RdRp) domain. Both enzymatic activities form attractive targets for antiviral development...
  20. Li X, Deng Y, Yang H, Zhao H, Jiang T, Yu X, et al. A chimeric dengue virus vaccine using Japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates. J Virol. 2013;87:13694-705 pubmed publisher
    ..of the well-known Japanese encephalitis virus live vaccine strain SA14-14-2 as a backbone, a novel chimeric dengue virus (named ChinDENV) was rationally designed and constructed by replacement with the premembrane and envelope genes ..
  21. Christian E, Kahle K, Mattia K, Puffer B, Pfaff J, Miller A, et al. Atomic-level functional model of dengue virus Envelope protein infectivity. Proc Natl Acad Sci U S A. 2013;110:18662-7 pubmed publisher
    A number of structures have been solved for the Envelope (E) protein from dengue virus and closely related flaviviruses, providing detailed pictures of the conformational states of the protein at different stages of infectivity...
  22. Zhou J, Zhang J, Sun D, Ma Q, Chen H, Ma L, et al. The distribution of synonymous codon choice in the translation initiation region of dengue virus. PLoS ONE. 2013;8:e77239 pubmed publisher
    ..The genetic features concerning the codon usage of dengue virus (DENV) were analyzed by the relative synonymous codon usage, the effective number of codons and the codon ..
  23. Green A, Beatty P, Hadjilaou A, Harris E. Innate immunity to dengue virus infection and subversion of antiviral responses. J Mol Biol. 2014;426:1148-60 pubmed publisher
    Dengue is a major public health issue in tropical and subtropical regions worldwide. The four serotypes of dengue virus (DENV1-DENV4) are spread primarily by Aedes aegypti and Aedes albopictus mosquitoes, whose geographic range continues ..
  24. Chan K, Ong E, Tan H, Zhang S, Zhang Q, Tang K, et al. Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue. Proc Natl Acad Sci U S A. 2014;111:2722-7 pubmed publisher
    ..During secondary infection with a heterologous dengue virus (DENV) serotype, DENV is opsonized with sub- or nonneutralizing antibodies that enhance infection of monocytes, ..
  25. Waggoner J, Abeynayake J, Sahoo M, Gresh L, Tellez Y, Gonzalez K, et al. Comparison of the FDA-approved CDC DENV-1-4 real-time reverse transcription-PCR with a laboratory-developed assay for dengue virus detection and serotyping. J Clin Microbiol. 2013;51:3418-20 pubmed publisher
    b>Dengue virus (DENV) is the agent of the most common vector-borne disease worldwide...
  26. Campbell K, Lin C, Iamsirithaworn S, Scott T. The complex relationship between weather and dengue virus transmission in Thailand. Am J Trop Med Hyg. 2013;89:1066-80 pubmed publisher
    Using a novel analytical approach, weather dynamics and seasonal dengue virus transmission cycles were profiled for each Thailand province, 1983-2001, using monthly assessments of cases, temperature, humidity, and rainfall...
  27. Lee Y, Hu H, Kuo S, Lei H, Lin Y, Yeh T, et al. Dengue virus infection induces autophagy: an in vivo study. J Biomed Sci. 2013;20:65 pubmed publisher
    ..We demonstrated that DV2 infection of the suckling mice induces autophagy, which plays a promoting role in DV replication and pathogenesis. ..
  28. Teoh B, Sam S, Tan K, Johari J, Shu M, Danlami M, et al. Dengue virus type 1 clade replacement in recurring homotypic outbreaks. BMC Evol Biol. 2013;13:213 pubmed publisher
    Recurring dengue outbreaks occur in cyclical pattern in most endemic countries. The recurrences of dengue virus (DENV) infection predispose the population to increased risk of contracting the severe forms of dengue...
  29. Rodriguez Barraquer I, Mier y Teran Romero L, Schwartz I, Burke D, Cummings D. Potential opportunities and perils of imperfect dengue vaccines. Vaccine. 2014;32:514-20 pubmed publisher
    ..Our results show that a partially effective vaccine can have significant impacts on serotype distribution and mean age of cases. ..
  30. Acosta E, Kumar A, Bartenschlager R. Revisiting dengue virus-host cell interaction: new insights into molecular and cellular virology. Adv Virus Res. 2014;88:1-109 pubmed publisher
    b>Dengue virus (DENV) is an emerging mosquito-borne human pathogen that affects millions of individuals each year by causing severe and potentially fatal syndromes...
  31. Yauch L, Shresta S. Dengue virus vaccine development. Adv Virus Res. 2014;88:315-72 pubmed publisher
    b>Dengue virus (DENV) is a significant cause of morbidity and mortality in tropical and subtropical regions, causing hundreds of millions of infections each year...
  32. Chatel Chaix L, Bartenschlager R. Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web. J Virol. 2014;88:5907-11 pubmed publisher
    b>Dengue virus (DENV) and hepatitis C virus (HCV), members of the family Flaviviridae, are global human health concerns...
  33. Sim S, Jupatanakul N, Ramirez J, Kang S, Romero Vivas C, Mohammed H, et al. Transcriptomic profiling of diverse Aedes aegypti strains reveals increased basal-level immune activation in dengue virus-refractory populations and identifies novel virus-vector molecular interactions. PLoS Negl Trop Dis. 2013;7:e2295 pubmed publisher
    ..among Aedes aegypti populations can greatly influence their vector competence for human pathogens such as the dengue virus (DENV)...
  34. Koo C, Nasir A, Hapuarachchi H, Lee K, Hasan Z, Ng L, et al. Evolution and heterogeneity of multiple serotypes of Dengue virus in Pakistan, 2006-2011. Virol J. 2013;10:275 pubmed publisher
    ..The genotypic diversity of Dengue virus (DENV) serotypes involved in dengue outbreaks since 2005 in Pakistan is not well studied...
  35. Chen H, King K, Tu J, Sanchez M, Luster A, Shresta S. The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus. J Immunol. 2013;191:4194-201 pubmed publisher
    We investigated the roles of IFN regulatory factor (IRF)-3 and IRF-7 in innate antiviral immunity against dengue virus (DENV)...
  36. Gordon A, Kuan G, Mercado J, Gresh L, Avilés W, Balmaseda A, et al. The Nicaraguan pediatric dengue cohort study: incidence of inapparent and symptomatic dengue virus infections, 2004-2010. PLoS Negl Trop Dis. 2013;7:e2462 pubmed publisher
    Dengue, caused by the four serotypes of dengue virus (DENV), is the most prevalent mosquito-borne viral disease of humans...
  37. Yoon I, Srikiatkhachorn A, Hermann L, Buddhari D, Scott T, Jarman R, et al. Characteristics of mild dengue virus infection in Thai children. Am J Trop Med Hyg. 2013;89:1081-7 pubmed publisher
    ..cohort and geographic cluster study in rural Thailand was conducted to characterize the clinical spectrum of dengue virus (DENV) infection...
  38. Junjhon J, Pennington J, Edwards T, Perera R, Lanman J, Kuhn R. Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells. J Virol. 2014;88:4687-97 pubmed publisher
    During dengue virus infection of host cells, intracellular membranes are rearranged into distinct subcellular structures such as double-membrane vesicles, convoluted membranes, and tubular structures...
  39. Sabchareon A, Sirivichayakul C, Limkittikul K, Chanthavanich P, Suvannadabba S, Jiwariyavej V, et al. Dengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009. PLoS Negl Trop Dis. 2012;6:e1732 pubmed publisher
    ..77% in 2006, 3.58% in 2007, 5.74% in 2008 and 3.29% in 2009. Mean dengue incidence over the 4 years was 3.6%. Dengue virus (DENV) types were determined in 333 (84...
  40. Azevedo A, Gonçalves A, Archer M, Freire M, Galler R, Alves A. The synergistic effect of combined immunization with a DNA vaccine and chimeric yellow fever/dengue virus leads to strong protection against dengue. PLoS ONE. 2013;8:e58357 pubmed publisher
    ..Results also revealed that immunization with the DNA vaccine, regardless of the combination with the chimeric virus, induced a robust cell immune response, with production of IFN-? by CD8+ T lymphocytes. ..
  41. Noble C, Lim S, Chen Y, Liew C, Yap L, Lescar J, et al. Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor. J Virol. 2013;87:5291-5 pubmed publisher
    We report a highly reproducible method to crystallize the RNA-dependent RNA polymerase (RdRp) domain of dengue virus serotype 3 (DENV-3), allowing structure refinement to a 1.79-Å resolution and revealing amino acids not seen previously...
  42. de Wispelaere M, Lacroix A, Yang P. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol. 2013;87:7367-81 pubmed publisher
    ..mechanism of action of AZD0530 and dasatinib, two pharmacological inhibitors of host kinases, that also inhibit dengue virus (DV) infection...
  43. Namekar M, Ellis E, O Connell M, Elm J, Gurary A, Park S, et al. Evaluation of a new commercially available immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of dengue virus infection. J Clin Microbiol. 2013;51:3102-6 pubmed publisher
    We evaluated the FDA-cleared InBios dengue virus (DENV) IgM capture enzyme-linked immunosorbent assay (ELISA) for qualitative detection of anti-DENV IgM antibodies from 79 serum samples obtained from dengue virus-infected patients or ..
  44. Lok S, Costin J, Hrobowski Y, Hoffmann A, Rowe D, Kukkaro P, et al. Release of dengue virus genome induced by a peptide inhibitor. PLoS ONE. 2012;7:e50995 pubmed publisher
    b>Dengue virus infects approximately 100 million people annually, but there is no available therapeutic treatment...
  45. Laughlin C, Morens D, Cassetti M, Costero Saint Denis A, San Martín J, Whitehead S, et al. Dengue research opportunities in the Americas. J Infect Dis. 2012;206:1121-7 pubmed publisher
    ..Although dengue is a major global tropical pathogen, epidemiologic and disease control considerations in this article emphasize dengue in the Americas. ..
  46. Groat Carmona A, Orozco S, Friebe P, Payne A, Kramer L, Harris E. A novel coding-region RNA element modulates infectious dengue virus particle production in both mammalian and mosquito cells and regulates viral replication in Aedes aegypti mosquitoes. Virology. 2012;432:511-26 pubmed publisher
    b>Dengue virus (DENV) is an enveloped flavivirus with a positive-sense RNA genome transmitted by Aedes mosquitoes, causing the most important arthropod-borne viral disease affecting humans...
  47. Dias L, Amarilla A, Poloni T, Covas D, Aquino V, Figueiredo L. Detection of dengue virus in sera of Brazilian blood donors. Transfusion. 2012;52:1667-71 pubmed publisher
    ..Further studies are needed to determine the risk of recipient infection by DENV as a result of transfusion in Brazil, especially during epidemic periods. ..
  48. Song K, Zhao H, Li S, Li X, Deng Y, Wang H, et al. Identification and characterization of a linearized B-cell epitope on the pr protein of dengue virus. J Gen Virol. 2013;94:1510-6 pubmed publisher
    The four serotypes of dengue virus (DENV) represent one of the major mosquito-borne pathogens globally; so far no vaccine or specific antiviral is available...
  49. Hannemann H, Sung P, Chiu H, Yousuf A, Bird J, Lim S, et al. Serotype-specific differences in dengue virus non-structural protein 5 nuclear localization. J Biol Chem. 2013;288:22621-35 pubmed publisher
    The four serotypes of dengue virus (DENV-1 to -4) cause the most important arthropod-borne viral disease of humans...
  50. Krishnan N, Purswani M, Hagmann S. Severe dengue virus infection in pediatric travelers visiting friends and relatives after travel to the Caribbean. Am J Trop Med Hyg. 2012;86:474-6 pubmed publisher
    ..Children of families originally from these locations may benefit from pre-travel advice and may represent candidates for a future dengue vaccine. ..
  51. Khan M, Ellis E, Tissera H, Alvi M, Rahman F, Masud F, et al. Emergence and diversification of dengue 2 cosmopolitan genotype in Pakistan, 2011. PLoS ONE. 2013;8:e56391 pubmed publisher
    ..These results highlight the increased diversity of dengue viruses as they spread geographically within the region. ..
  52. Alfonso H, Amarilla A, Gonçalves P, Barros M, de Almeida F, Silva T, et al. Phylogenetic relationship of dengue virus type 3 isolated in Brazil and Paraguay and global evolutionary divergence dynamics. Virol J. 2012;9:124 pubmed publisher
    Dengue is the most important mosquito-borne viral disease worldwide. Dengue virus comprises four antigenically related viruses named dengue virus type 1 to 4 (DENV1-4)...
  53. Deng J, Toh C. Impedimetric DNA biosensor based on a nanoporous alumina membrane for the detection of the specific oligonucleotide sequence of dengue virus. Sensors (Basel). 2013;13:7774-85 pubmed publisher
    ..This study reveals a simple, selective and sensitive method to fabricate a label-free DNA biosensor. ..
  54. Wahala W, Silva A. The human antibody response to dengue virus infection. Viruses. 2011;3:2374-95 pubmed publisher
    ..By understanding how human antibodies neutralize or enhance DENV, it will be possible to better evaluate existing vaccines and develop the next generation of novel vaccines. ..
  55. Flipse J, Wilschut J, Smit J. Molecular mechanisms involved in antibody-dependent enhancement of dengue virus infection in humans. Traffic. 2013;14:25-35 pubmed publisher
    ..In this review, we discuss what is known about the trafficking of dengue virus in its human host cells, and the signalling pathways activated after virus detection, both in the absence and ..
  56. Nguyen N, Tran C, Phung L, Duong K, Huynh H, Farrar J, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis. 2013;207:1442-50 pubmed publisher
    ..nct01096576. ..
  57. Drumond B, Mondini A, Schmidt D, de Morais Bronzoni R, Bosch I, Nogueira M. Circulation of different lineages of Dengue virus 2, genotype American/Asian in Brazil: dynamics and molecular and phylogenetic characterization. PLoS ONE. 2013;8:e59422 pubmed publisher
    The American/Asian genotype of Dengue virus type 2 (DENV-2) was introduced into the Americas in the 80's. Although there is no data showing when this genotype was first introduced into Brazil, it was first detected in Brazil in 1990...
  58. Munoz Jordan J, Santiago G, Margolis H, Stark L. Genetic relatedness of dengue viruses in Key West, Florida, USA, 2009-2010. Emerg Infect Dis. 2013;19:652-4 pubmed publisher
    Sequencing of dengue virus type 1 (DENV-1) strains isolated in Key West/Monroe County, Florida, indicate endemic transmission for >2 years of a distinct and predominant sublineage of the American-African genotype...
  59. Li J, Huang R, Liao W, Chen Z, Zhang S, Huang R. Dengue virus utilizes calcium modulating cyclophilin-binding ligand to subvert apoptosis. Biochem Biophys Res Commun. 2012;418:622-7 pubmed publisher
    b>Dengue virus (DENV) capsid (C) proteins are the major structural component of virus particles. This study aimed to identify the host interacting partners of DENV C protein that could contribute to viral pathogenesis...
  60. Martins I, Gomes Neto F, Faustino A, Carvalho F, Carneiro F, Bozza P, et al. The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif. Biochem J. 2012;444:405-15 pubmed publisher
    ..potential measurements and atomic force microscopy to study the structural features of the interaction between dengue virus C (capsid) protein and LDs (lipid droplets), organelles crucial for infectious particle formation...
  61. Wang Z, Li L, Pennington J, Sheng J, Yap M, Plevka P, et al. Obstruction of dengue virus maturation by Fab fragments of the 2H2 antibody. J Virol. 2013;87:8909-15 pubmed publisher
    The 2H2 monoclonal antibody recognizes the precursor peptide on immature dengue virus and might therefore be a useful tool for investigating the conformational change that occurs when the immature virus enters an acidic environment...
  62. Wan S, Lin C, Wang S, Chen Y, Yeh T, Liu H, et al. Current progress in dengue vaccines. J Biomed Sci. 2013;20:37 pubmed publisher
    ..For the safety and efficacy of dengue vaccines, the immunopathogenic complications such as antibody-mediated enhancement and autoimmunity of dengue disease need to be considered. ..
  63. Testa J, Shetty V, Sinnathamby G, Nickens Z, Hafner J, Kamal S, et al. Conserved MHC class I-presented dengue virus epitopes identified by immunoproteomics analysis are targets for cross-serotype reactive T-cell response. J Infect Dis. 2012;205:647-55 pubmed publisher
    ..In this study, we utilize an immunoproteomics process to uncover novel HLA-A2-specific epitopes derived from dengue virus (DV)-infected cells...
  64. Chan Y, Huang I, Farzan M. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE. 2012;7:e34508 pubmed publisher
    ..restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV)...
  65. Anders K, Nguyet N, Quyen N, Ngoc T, Tram T, Gan T, et al. An evaluation of dried blood spots and oral swabs as alternative specimens for the diagnosis of dengue and screening for past dengue virus exposure. Am J Trop Med Hyg. 2012;87:165-70 pubmed publisher
    ..oral swabs and dried blood spots (DBS), compared with plasma, in diagnosing acute dengue and screening for past dengue virus (DENV) exposure...
  66. Chao D, Halstead S, Halloran M, Longini I. Controlling dengue with vaccines in Thailand. PLoS Negl Trop Dis. 2012;6:e1876 pubmed publisher
    ..According to our modeling results, children should be prioritized to receive vaccine, but adults will also need to be vaccinated if one wants to reduce community-wide dengue transmission to low levels. ..
  67. Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, et al. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood. 2013;121:95-106 pubmed publisher
    Persistent high fever is one of the most typical clinical symptoms in dengue virus (DV)-infected patients...
  68. De Burghgraeve T, Kaptein S, Ayala Nuñez N, Mondotte J, Pastorino B, Printsevskaya S, et al. An analogue of the antibiotic teicoplanin prevents flavivirus entry in vitro. PLoS ONE. 2012;7:e37244 pubmed publisher
    There is an urgent need for potent inhibitors of dengue virus (DENV) replication for the treatment and/or prophylaxis of infections with this virus...
  69. Timiryasova T, Bonaparte M, Luo P, Zedar R, Hu B, Hildreth S. Optimization and validation of a plaque reduction neutralization test for the detection of neutralizing antibodies to four serotypes of dengue virus used in support of dengue vaccine development. Am J Trop Med Hyg. 2013;88:962-70 pubmed publisher
  70. Voge N, Sanchez Vargas I, Blair C, Eisen L, Beaty B. Detection of dengue virus NS1 antigen in infected Aedes aegypti using a commercially available kit. Am J Trop Med Hyg. 2013;88:260-6 pubmed publisher
    Epidemic dengue has emerged throughout the tropical world. In the continued absence of a vaccine against dengue virus (DENV), mosquito vector surveillance and control programs are essential to reduce human infections...
  71. Yoon I, Getis A, Aldstadt J, Rothman A, Tannitisupawong D, Koenraadt C, et al. Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. PLoS Negl Trop Dis. 2012;6:e1730 pubmed publisher
    Based on spatiotemporal clustering of human dengue virus (DENV) infections, transmission is thought to occur at fine spatiotemporal scales by horizontal transfer of virus between humans and mosquito vectors...
  72. Hertz J, Munishi O, Ooi E, Howe S, Lim W, Chow A, et al. Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania. Am J Trop Med Hyg. 2012;86:171-7 pubmed publisher
    ..Confirmed acute Chikungunya virus (CHIKV), Dengue virus (DENV), and flavivirus infection were defined as a positive polymerase chain reaction (PCR) result...
  73. Wahala W, Huang C, Butrapet S, White L, de Silva A. Recombinant dengue type 2 viruses with altered e protein domain III epitopes are efficiently neutralized by human immune sera. J Virol. 2012;86:4019-23 pubmed publisher
    Humans develop polyclonal, serotype-specific neutralizing antibody responses after dengue virus (DENV) infection...
  74. Brady O, Gething P, Bhatt S, Messina J, Brownstein J, Hoen A, et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Negl Trop Dis. 2012;6:e1760 pubmed publisher
    ..determined here using evidence consensus, marks the beginning of a five-year study to advance the mapping of dengue virus transmission and disease risk...
  75. Noisakran S, Onlamoon N, Pattanapanyasat K, Hsiao H, Songprakhon P, Angkasekwinai N, et al. Role of CD61+ cells in thrombocytopenia of dengue patients. Int J Hematol. 2012;96:600-10 pubmed publisher
    ..patients, the role of CD61-expressing platelets and the megakaryocytic cell lineage in the pathogenesis of dengue virus (DENV) infection remains largely unexplored...
  76. Selisko B, Potisopon S, Agred R, Priet S, Varlet I, Thillier Y, et al. Molecular basis for nucleotide conservation at the ends of the dengue virus genome. PLoS Pathog. 2012;8:e1002912 pubmed publisher
    The dengue virus (DV) is an important human pathogen from the Flavivirus genus, whose genome- and antigenome RNAs start with the strictly conserved sequence pppAG...
  77. Costin J, Zaitseva E, Kahle K, Nicholson C, Rowe D, Graham A, et al. Mechanistic study of broadly neutralizing human monoclonal antibodies against dengue virus that target the fusion loop. J Virol. 2013;87:52-66 pubmed publisher
    ..Mechanistic studies with anti-dengue virus (DENV) human monoclonal antibodies (hMAbs) provide a rational approach to identify and characterize ..
  78. Dias A, Gomes Filho S, Silva M, Dutra R. A sensor tip based on carbon nanotube-ink printed electrode for the dengue virus NS1 protein. Biosens Bioelectron. 2013;44:216-21 pubmed publisher
    An immunosensor for the non-structural protein 1 (NS1) of the dengue virus based on carbon nanotube-screen printed electrodes (CNT-SPE) was successfully developed...
  79. Kakumani P, Ponia S, S R, Sood V, Chinnappan M, Banerjea A, et al. Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor. J Virol. 2013;87:8870-83 pubmed publisher
    ..In the present study, we demonstrate the anti-dengue virus role of RNAi in mammalian cells...
  80. Yang J, Zhang J, Chen W, Hu Z, Zhu J, Fang X, et al. Eliciting cross-neutralizing antibodies in mice challenged with a dengue virus envelope domain III expressed in Escherichia coli. Can J Microbiol. 2012;58:369-80 pubmed publisher
    ..These data suggest that a candidate molecule based on the small EDIII protein, which has neutralizing epitopes conserved among all 4 DENV serotypes, has important implications. ..
  81. Zhang G, Hussain M, O Neill S, Asgari S. Wolbachia uses a host microRNA to regulate transcripts of a methyltransferase, contributing to dengue virus inhibition in Aedes aegypti. Proc Natl Acad Sci U S A. 2013;110:10276-81 pubmed publisher
    ..that in mosquitoes the introduced endosymbiont, Wolbachia, significantly suppresses expression of AaDnmt2, but dengue virus induces expression of AaDnmt2...
  82. Barban V, Munoz Jordan J, Santiago G, Mantel N, Girerd Y, Gulia S, et al. Broad neutralization of wild-type dengue virus isolates following immunization in monkeys with a tetravalent dengue vaccine based on chimeric yellow fever 17D/dengue viruses. Virology. 2012;429:91-8 pubmed publisher
    ..These data indicate that antibodies elicited after immunization with this dengue vaccine candidate should widely protect against infection with contemporary DENV lineages circulating in endemic countries. ..
  83. Halsey E, Marks M, Gotuzzo E, Fiestas V, Suarez L, Vargas J, et al. Correlation of serotype-specific dengue virus infection with clinical manifestations. PLoS Negl Trop Dis. 2012;6:e1638 pubmed publisher
    Disease caused by the dengue virus (DENV) is a significant cause of morbidity throughout the world...
  84. Pena J, Harris E. Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway. PLoS ONE. 2012;7:e38202 pubmed publisher
    ..In this study, we used dengue virus (DENV) to study the role of the unfolded protein response (UPR) and sterol-regulatory-element-binding-protein-2 ..
  85. Hidari K, Ikeda K, Watanabe I, Abe T, Sando A, Itoh Y, et al. 3-O-sulfated glucuronide derivative as a potential anti-dengue virus agent. Biochem Biophys Res Commun. 2012;424:573-8 pubmed publisher
    ..by introduction of a sulfated group at specific positions and evaluated for their activities against dengue virus (DENV) infection as well as binding to BHK-21 cells...
  86. Byrd C, Dai D, Grosenbach D, Berhanu A, Jones K, Cardwell K, et al. A novel inhibitor of dengue virus replication that targets the capsid protein. Antimicrob Agents Chemother. 2013;57:15-25 pubmed publisher
    ..Thus, ST-148 appears to interact with the DENV C protein and inhibits a distinct step(s) of the viral replication cycle. ..
  87. Sylvestre G, Gandini M, Maciel de Freitas R. Age-dependent effects of oral infection with dengue virus on Aedes aegypti (Diptera: Culicidae) feeding behavior, survival, oviposition success and fecundity. PLoS ONE. 2013;8:e59933 pubmed publisher
    ..Despite its public health importance, the effect of dengue virus (DENV) on some mosquito traits remains unknown...
  88. Bhatnagar J, Blau D, Shieh W, Paddock C, Drew C, Liu L, et al. Molecular detection and typing of dengue viruses from archived tissues of fatal cases by rt-PCR and sequencing: diagnostic and epidemiologic implications. Am J Trop Med Hyg. 2012;86:335-40 pubmed publisher
    Diagnosis of dengue virus (DENV) infection in fatal cases is challenging because of the frequent unavailability of blood or fresh tissues...
  89. Chao B, Tong X, Tang W, Li D, He P, Garcia J, et al. Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. J Med Chem. 2012;55:3135-43 pubmed publisher
    ..screening assay using the DENV-2 replicon showed that the 2,4-diaminoquinazoline derivative 4a has a high dengue virus inhibitory activity (EC(50) = 0.15 ?M)...
  90. Anders K, Hay S. Lessons from malaria control to help meet the rising challenge of dengue. Lancet Infect Dis. 2012;12:977-84 pubmed publisher
    ..Control of dengue is unlikely to be achieved without coordinated international financial and technical support for national programmes, which has proven effective in reducing the global burden of malaria. ..
  91. Lu H, Xu X, Gao N, Fan D, Wang J, An J. Preliminary evaluation of DNA vaccine candidates encoding dengue-2 prM/E and NS1: their immunity and protective efficacy in mice. Mol Immunol. 2013;54:109-14 pubmed publisher
    Public health is still seriously threatened by dengue virus (DENV) and no vaccine against DENV is yet available for clinical use till now...
  92. Wu H, Wang C, Teng H, Lin C, Lu L, Jian S, et al. A dengue vector surveillance by human population-stratified ovitrap survey for Aedes (Diptera: Culicidae) adult and egg collections in high dengue-risk areas of Taiwan. J Med Entomol. 2013;50:261-9 pubmed
    ..Therefore, our survey identified the whole year oviposition activity, spatial-temporal distribution of the local Ae. aegypti population and a 14 wk lag correlation with dengue incidence to plan an effectively proactive control. ..